SIMILAR PATTERNS OF AMINO ACIDS FOR 4EAT_A_BEZA1000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)


(Thermotoga
maritima)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ALA A 238
ILE A 246
GLY A 245
ILE A 276
None
0.66A 4eatA-1b3bA:
3.2
4eatA-1b3bA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqc PROTEIN
(BETA-MANNANASE)


(Thermobifida
fusca)
PF00150
(Cellulase)
4 ALA A 295
GLY A 250
ILE A 252
GLY A  23
None
0.57A 4eatA-1bqcA:
undetectable
4eatA-1bqcA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II


(Homo sapiens)
PF00080
(Sod_Cu)
5 ALA A  91
ALA A 226
GLY A  94
GLY A 101
ILE A 119
None
1.17A 4eatA-1do5A:
undetectable
4eatA-1do5A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
SMALL SUBUNIT


(Desulfovibrio
desulfuricans)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
4 ALA A 122
GLY A  76
ILE A 133
GLY A 132
None
FSX  A 269 ( 4.1A)
None
None
0.66A 4eatA-1e3dA:
undetectable
4eatA-1e3dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE


(Rattus
norvegicus)
PF00106
(adh_short)
4 ALA A  92
GLY A  21
GLY A  18
ILE A  15
NAD  A 301 (-3.6A)
NAD  A 301 (-3.2A)
None
None
0.67A 4eatA-1e6wA:
3.5
4eatA-1e6wA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE


(Thermococcus
profundus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ALA A 241
ILE A 249
GLY A 248
ILE A 279
None
0.55A 4eatA-1euzA:
4.2
4eatA-1euzA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ


(Phaseolus
vulgaris)
PF00139
(Lectin_legB)
4 ALA A  89
ALA A 176
GLY A 139
ILE A 138
None
0.68A 4eatA-1g8wA:
undetectable
4eatA-1g8wA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtm GLUTAMATE
DEHYDROGENASE


(Pyrococcus
furiosus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ALA A 241
ILE A 249
GLY A 248
ILE A 279
None
0.59A 4eatA-1gtmA:
2.8
4eatA-1gtmA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))


(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris)
PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10)
PF02256
(Fe_hyd_SSU)
4 ALA L 113
TYR L 112
GLY S  49
ILE S  47
None
0.64A 4eatA-1hfeL:
2.1
4eatA-1hfeL:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1in8 HOLLIDAY JUNCTION
DNA HELICASE RUVB


(Thermotoga
maritima)
PF05491
(RuvB_C)
PF05496
(RuvB_N)
4 GLY A 313
ILE A 315
GLY A 275
ILE A 268
None
0.62A 4eatA-1in8A:
2.9
4eatA-1in8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 ALA A 466
GLY A 427
GLY A 432
ILE A 433
None
0.63A 4eatA-1itzA:
2.1
4eatA-1itzA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy8 LEVODIONE REDUCTASE

(Leifsonia
aquatica)
PF13561
(adh_short_C2)
4 ALA A 100
GLY A  24
GLY A  21
ILE A  18
NAD  A1268 ( 3.7A)
NAD  A1268 (-3.3A)
None
None
0.65A 4eatA-1iy8A:
3.7
4eatA-1iy8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE


(Pectobacterium
carotovorum)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
4 ALA A  68
GLY A  67
ILE A  65
ILE A 186
None
0.67A 4eatA-1khdA:
undetectable
4eatA-1khdA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kk0 EIF2GAMMA

(Pyrococcus
abyssi)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C)
4 ALA A 185
GLY A 184
ILE A 179
ILE A 147
None
0.68A 4eatA-1kk0A:
2.8
4eatA-1kk0A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ph5 TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT


(Sterkiella nova)
PF02765
(POT1)
5 ALA A 306
ALA A 116
GLY A 117
ILE A  59
ILE A 206
None
1.48A 4eatA-1ph5A:
undetectable
4eatA-1ph5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)


(Homo sapiens)
PF00753
(Lactamase_B)
PF16123
(HAGH_C)
4 ALA A  60
GLY A  61
GLY A  83
ILE A  82
None
0.63A 4eatA-1qh5A:
undetectable
4eatA-1qh5A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc2 AQUAPORIN Z

(Escherichia
coli)
no annotation 4 ALA B  65
GLY B 220
ILE B 218
GLY B 215
None
0.68A 4eatA-1rc2B:
undetectable
4eatA-1rc2B:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE


(Escherichia
coli)
PF00348
(polyprenyl_synt)
4 ALA A 137
ALA A  61
GLY A  60
ILE A  43
None
0.67A 4eatA-1rqjA:
undetectable
4eatA-1rqjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg9 HEMK PROTEIN

(Thermotoga
maritima)
PF05175
(MTS)
4 ALA A 156
ALA A 149
ILE A 128
GLY A 129
SAM  A 301 ( 4.7A)
None
None
SAM  A 301 (-3.3A)
0.59A 4eatA-1sg9A:
2.4
4eatA-1sg9A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE


(Sulfurisphaera
tokodaii)
PF00908
(dTDP_sugar_isom)
4 ALA A  84
GLY A  70
ILE A  72
ILE A  73
None
0.67A 4eatA-1wltA:
undetectable
4eatA-1wltA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x68 FHL5 PROTEIN

(Homo sapiens)
PF00412
(LIM)
4 ALA A  21
GLY A  20
GLY A  17
ILE A  15
None
0.57A 4eatA-1x68A:
undetectable
4eatA-1x68A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7r HYPOTHETICAL PROTEIN
SA2161


(Staphylococcus
aureus)
PF13673
(Acetyltransf_10)
4 ALA A  21
GLY A  81
GLY A  52
ILE A  51
None
PO4  A 504 ( 3.3A)
None
None
0.58A 4eatA-1y7rA:
undetectable
4eatA-1y7rA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE


(Thermotoga
maritima)
PF00294
(PfkB)
4 ALA A 306
GLY A 289
ILE A 287
GLY A 284
None
0.61A 4eatA-2afbA:
undetectable
4eatA-2afbA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d57 AQUAPORIN-4

(Rattus
norvegicus)
PF00230
(MIP)
5 ALA A 215
ALA A 130
ILE A 128
GLY A 125
ILE A 127
None
0.94A 4eatA-2d57A:
undetectable
4eatA-2d57A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e54 ACETYLORNITHINE
AMINOTRANSFERASE


(Thermotoga
maritima)
PF00202
(Aminotran_3)
4 ALA A 353
ILE A 326
GLY A 327
ILE A 328
None
0.66A 4eatA-2e54A:
undetectable
4eatA-2e54A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4n HYPOTHETICAL PROTEIN
MJ1651


(Methanocaldococcus
jannaschii)
PF01887
(SAM_adeno_trans)
5 ALA A 116
ALA A  64
ILE A  60
GLY A 110
ILE A 168
None
0.89A 4eatA-2f4nA:
undetectable
4eatA-2f4nA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe7 PROBABLE
N-ACETYLTRANSFERASE


(Pseudomonas
aeruginosa)
PF00583
(Acetyltransf_1)
4 ALA A  97
GLY A  98
GLY A  64
ILE A  63
None
0.58A 4eatA-2fe7A:
undetectable
4eatA-2fe7A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE


(Shewanella
oneidensis)
PF00920
(ILVD_EDD)
5 ALA A 314
ALA A 165
GLY A 164
GLY A 169
ILE A 278
None
1.18A 4eatA-2gp4A:
2.5
4eatA-2gp4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grj DEPHOSPHO-COA KINASE

(Thermotoga
maritima)
PF01121
(CoaE)
4 GLY A   7
ILE A   9
GLY A  10
ILE A 131
None
COD  A 201 (-3.8A)
ADP  A 200 (-3.5A)
None
0.67A 4eatA-2grjA:
undetectable
4eatA-2grjA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzm GLUTAMATE RACEMASE

(Bacillus
anthracis)
PF01177
(Asp_Glu_race)
4 ALA A  79
GLY A 117
ILE A 119
GLY A 120
None
0.68A 4eatA-2gzmA:
2.7
4eatA-2gzmA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsd 3-ALPHA, 20
BETA-HYDROXYSTEROID
DEHYDROGENASE


(Streptomyces
exfoliatus)
PF13561
(adh_short_C2)
4 ALA A  88
GLY A  17
GLY A  14
ILE A  11
NAD  A 256 (-3.2A)
NAD  A 256 (-3.1A)
None
None
0.65A 4eatA-2hsdA:
3.7
4eatA-2hsdA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001


(Neisseria
meningitidis)
PF08794
(Lipoprot_C)
4 ALA A 114
GLY A 169
ILE A 255
GLY A 256
None
0.62A 4eatA-2kdyA:
undetectable
4eatA-2kdyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P1


(Homo sapiens)
PF00428
(Ribosomal_60s)
4 ALA A  50
ALA A  13
ILE A  10
ILE A  56
None
0.63A 4eatA-2lbfA:
undetectable
4eatA-2lbfA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oce HYPOTHETICAL PROTEIN
PA5201


(Pseudomonas
aeruginosa)
PF00575
(S1)
PF09371
(Tex_N)
PF12836
(HHH_3)
PF16921
(Tex_YqgF)
4 ALA A 424
GLY A 333
ILE A 389
GLY A 390
None
0.61A 4eatA-2oceA:
2.7
4eatA-2oceA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ow4 CANAVALIA MARITIMA
LECTIN


(Canavalia rosea)
PF00139
(Lectin_legB)
4 ALA A 211
ALA A  63
GLY A  26
ILE A  25
None
0.60A 4eatA-2ow4A:
undetectable
4eatA-2ow4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5i BH3822 PROTEIN

(Bacillus
halodurans)
PF03099
(BPL_LplA_LipB)
4 ALA A 142
ALA A 164
GLY A 165
ILE A 129
None
0.64A 4eatA-2p5iA:
undetectable
4eatA-2p5iA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pth PEPTIDYL-TRNA
HYDROLASE


(Escherichia
coli)
PF01195
(Pept_tRNA_hydro)
4 ALA A 102
ALA A  22
GLY A  23
ILE A 161
None
0.56A 4eatA-2pthA:
undetectable
4eatA-2pthA:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2v7b BENZOATE-COENZYME A
LIGASE


(Paraburkholderia
xenovorans)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
7 ALA A 237
TYR A 238
ALA A 308
GLY A 309
ILE A 332
GLY A 333
ILE A 340
BEZ  A1529 ( 3.7A)
BEZ  A1529 (-4.3A)
BEZ  A1529 (-3.6A)
BEZ  A1529 (-3.5A)
None
BEZ  A1529 (-3.6A)
BEZ  A1529 ( 4.9A)
0.24A 4eatA-2v7bA:
62.0
4eatA-2v7bA:
60.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjh PHYCOERYTHRIN BETA
SUBUNIT


(Gloeobacter
violaceus)
PF00502
(Phycobilisome)
4 ALA B 140
ALA B 165
GLY B 166
ILE B  44
PUB  B1050 ( 4.0A)
None
None
None
0.66A 4eatA-2vjhB:
undetectable
4eatA-2vjhB:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2g NON-STRUCTURAL
PROTEIN 3


(Severe acute
respiratory
syndrome-related
coronavirus)
PF11633
(SUD-M)
4 ALA A 493
GLY A 609
ILE A 592
ILE A 593
None
0.68A 4eatA-2w2gA:
2.3
4eatA-2w2gA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc7 ALPHA AMYLASE,
CATALYTIC REGION


(Nostoc
punctiforme)
PF00128
(Alpha-amylase)
PF11941
(DUF3459)
4 ALA A 400
GLY A 485
ILE A 428
ILE A 429
None
0.65A 4eatA-2wc7A:
undetectable
4eatA-2wc7A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
4 GLY A  84
ILE A 108
GLY A 143
ILE A 142
None
0.66A 4eatA-2zsuA:
2.3
4eatA-2zsuA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN


(Enterococcus
faecalis)
PF06545
(DUF1116)
4 ALA A 159
ALA A 122
GLY A 121
ILE A  99
None
0.66A 4eatA-3clqA:
undetectable
4eatA-3clqA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR


(Homo sapiens)
PF00041
(fn3)
4 ALA A 278
GLY A 279
GLY A 213
ILE A 253
None
0.65A 4eatA-3e0gA:
undetectable
4eatA-3e0gA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7g UPF0311 PROTEIN
CA_C3321


(Clostridium
acetobutylicum)
PF11578
(DUF3237)
5 ALA A  78
ALA A  75
ILE A  60
GLY A  59
ILE A  41
None
0.88A 4eatA-3g7gA:
undetectable
4eatA-3g7gA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga7 ACETYL ESTERASE

(Salmonella
enterica)
PF07859
(Abhydrolase_3)
4 ALA A  85
ILE A 159
GLY A 160
ILE A 189
None
0.57A 4eatA-3ga7A:
3.4
4eatA-3ga7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hee RIBOSE-5-PHOSPHATE
ISOMERASE


(Ruminiclostridium
thermocellum)
PF02502
(LacAB_rpiB)
5 ALA A  52
GLY A   6
ILE A  62
GLY A  61
ILE A 103
None
0.79A 4eatA-3heeA:
2.7
4eatA-3heeA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3y CARBOHYDRATE KINASE

(Klebsiella
pneumoniae)
PF00294
(PfkB)
4 ALA A  41
GLY A  40
GLY A  37
ILE A  36
None
0.64A 4eatA-3i3yA:
3.3
4eatA-3i3yA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijp DIHYDRODIPICOLINATE
REDUCTASE


(Bartonella
henselae)
PF01113
(DapB_N)
PF05173
(DapB_C)
4 ALA A  64
ALA A   8
GLY A   7
ILE A  57
None
None
NAP  A 300 (-3.3A)
None
0.64A 4eatA-3ijpA:
2.4
4eatA-3ijpA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcp GLUCOKINASE

(Parabacteroides
distasonis)
PF00480
(ROK)
4 TYR A  79
ALA A  77
ILE A  83
GLY A  82
None
0.62A 4eatA-3mcpA:
undetectable
4eatA-3mcpA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE


(Shigella
flexneri)
PF00145
(DNA_methylase)
5 TYR A 124
ALA A  94
GLY A  95
ILE A  99
GLY A  98
None
1.35A 4eatA-3me5A:
2.4
4eatA-3me5A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqg LIPOPOLYSACCHARIDES
BIOSYNTHESIS
ACETYLTRANSFERASE


(Bordetella
petrii)
PF00132
(Hexapep)
5 ALA A 141
ALA A 107
GLY A 106
GLY A 122
ILE A 121
None
1.12A 4eatA-3mqgA:
undetectable
4eatA-3mqgA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oby PROTEIN PELOTA
HOMOLOG


(Archaeoglobus
fulgidus)
PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3)
4 ALA A 191
GLY A 192
GLY A 227
ILE A 231
None
0.68A 4eatA-3obyA:
undetectable
4eatA-3obyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE


(Ruminiclostridium
thermocellum)
PF02502
(LacAB_rpiB)
5 ALA A  52
GLY A   6
ILE A  62
GLY A  61
ILE A 103
None
0.78A 4eatA-3ph3A:
2.5
4eatA-3ph3A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)


(Leishmania
infantum)
PF00215
(OMPdecase)
4 ALA A  96
TYR A  95
GLY A  86
ILE A  88
None
0.64A 4eatA-3qw3A:
undetectable
4eatA-3qw3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9w GTPASE ERA

(Aquifex
aeolicus)
PF01926
(MMR_HSR1)
PF07650
(KH_2)
4 ALA A 160
GLY A 159
ILE A 154
ILE A 125
None
0.65A 4eatA-3r9wA:
4.6
4eatA-3r9wA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE


(Schizosaccharomyces
pombe)
PF00180
(Iso_dh)
4 ALA A 300
ALA A  78
GLY A  77
GLY A  16
GOL  A 365 (-4.0A)
None
None
None
0.68A 4eatA-3ty4A:
undetectable
4eatA-3ty4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN


(Streptococcus
pneumoniae)
PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix)
4 ALA A 343
TYR A 342
ILE A 273
GLY A 274
None
0.62A 4eatA-3zppA:
undetectable
4eatA-3zppA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata)
PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s)
4 ALA A  79
ILE A  33
GLY A  34
ILE A  38
None
0.68A 4eatA-4bedA:
undetectable
4eatA-4bedA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE


(Gluconacetobacter
diazotrophicus)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 ALA A 183
ALA A  66
GLY A  65
GLY A  17
None
0.58A 4eatA-4cokA:
4.8
4eatA-4cokA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0u ALLOPHYCOCYANIN
ALPHA CHAIN


(Synechococcus
elongatus)
PF00502
(Phycobilisome)
4 ALA A 142
ALA A 162
GLY A 163
ILE A  44
None
0.58A 4eatA-4f0uA:
undetectable
4eatA-4f0uA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g81 PUTATIVE HEXONATE
DEHYDROGENASE


(Salmonella
enterica)
no annotation 4 ALA D 187
ILE D 145
GLY D 146
ILE D 167
None
0.68A 4eatA-4g81D:
3.4
4eatA-4g81D:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE


(Archaeoglobus
fulgidus)
PF02289
(MCH)
4 ALA A 114
GLY A  96
GLY A 110
ILE A 137
None
0.64A 4eatA-4gvrA:
undetectable
4eatA-4gvrA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcj THIJ/PFPI DOMAIN
PROTEIN


(Brachyspira
murdochii)
PF01965
(DJ-1_PfpI)
5 ALA A 165
ALA A 102
GLY A 103
ILE A 150
ILE A 100
None
1.13A 4eatA-4hcjA:
undetectable
4eatA-4hcjA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSA

(Sporomusa ovata)
PF02277
(DBI_PRT)
4 ALA A 222
ALA A 191
GLY A 190
ILE A 188
None
0.65A 4eatA-4hdsA:
undetectable
4eatA-4hdsA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE


(Xanthomonas
campestris)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
4 ALA A  60
GLY A  59
ILE A  57
ILE A 178
None
0.65A 4eatA-4hkmA:
undetectable
4eatA-4hkmA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4is2 BILE ACID 3-ALPHA
HYDROXYSTEROID
DEHYDROGENASE


([Clostridium]
scindens)
PF00106
(adh_short)
4 ALA A  93
GLY A  17
GLY A  14
ILE A  11
None
0.67A 4eatA-4is2A:
3.7
4eatA-4is2A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN


(Paracoccus
denitrificans)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ALA A 129
ALA A 121
ILE A 308
GLY A 309
None
0.51A 4eatA-4izgA:
undetectable
4eatA-4izgA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbh ALCOHOL
DEHYDROGENASE (ZINC)


(Pyrobaculum
aerophilum)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ALA A  52
GLY A 111
ILE A 113
GLY A 114
None
0.67A 4eatA-4jbhA:
5.1
4eatA-4jbhA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1


(Staphylococcus
aureus)
PF13614
(AAA_31)
4 ALA A1067
TYR A1066
ILE A1154
ILE A1155
None
0.63A 4eatA-4jlvA:
2.8
4eatA-4jlvA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF00814
(Peptidase_M22)
4 ALA A  37
GLY A 142
ILE A 373
GLY A 370
None
0.63A 4eatA-4k25A:
undetectable
4eatA-4k25A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE


(Haemophilus
influenzae)
PF01380
(SIS)
4 GLY A 103
ILE A  74
GLY A  75
ILE A 144
None
0.64A 4eatA-4m0dA:
undetectable
4eatA-4m0dA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A


(Streptococcus
pneumoniae)
PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix)
4 ALA A 354
TYR A 353
ILE A 284
GLY A 285
None
0.65A 4eatA-4mr0A:
undetectable
4eatA-4mr0A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mup AMIDOHYDROLASE

(Agrobacterium
fabrum)
PF04909
(Amidohydro_2)
5 ALA A  16
ALA A  21
GLY A  20
ILE A  62
GLY A  61
None
1.38A 4eatA-4mupA:
undetectable
4eatA-4mupA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n80 UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
no annotation 4 ALA A 396
TYR A 397
ILE A 243
GLY A 244
None
0.50A 4eatA-4n80A:
undetectable
4eatA-4n80A:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0l NADPH-DEPENDENT
3-QUINUCLIDINONE
REDUCTASE


(Rhodotorula
mucilaginosa)
PF13561
(adh_short_C2)
4 ALA A 114
GLY A  39
GLY A  36
ILE A  33
NDP  A 300 (-3.7A)
NDP  A 300 (-3.7A)
None
None
0.68A 4eatA-4o0lA:
3.2
4eatA-4o0lA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r37 PUTATIVE
ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Bacteroides
fragilis)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
4 TYR A 212
ILE A 179
GLY A 189
ILE A 190
None
0.68A 4eatA-4r37A:
undetectable
4eatA-4r37A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus)
PF03512
(Glyco_hydro_52)
4 GLY A 162
ILE A  45
GLY A  46
ILE A  58
None
0.68A 4eatA-4rhhA:
undetectable
4eatA-4rhhA:
22.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rlq BENZOATE-COENZYME A
LIGASE


(Rhodopseudomonas
palustris)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
7 ALA A 227
TYR A 228
ALA A 302
GLY A 303
ILE A 326
GLY A 327
ILE A 334
3SK  A1000 (-3.6A)
3SK  A1000 (-4.8A)
3SK  A1000 ( 3.8A)
3SK  A1000 (-3.3A)
3SK  A1000 (-4.4A)
3SK  A1000 (-3.6A)
None
0.10A 4eatA-4rlqA:
73.0
4eatA-4rlqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tuf MAJOR EXTRACELLULAR
ENDOGLUCANASE


(Xanthomonas
campestris)
PF00150
(Cellulase)
4 ALA A 294
GLY A 295
GLY A 330
ILE A 331
None
0.63A 4eatA-4tufA:
undetectable
4eatA-4tufA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u36 SEED LECTIN

(Vatairea
macrocarpa)
PF00139
(Lectin_legB)
4 ALA A  90
ALA A 176
GLY A 139
ILE A 138
None
0.68A 4eatA-4u36A:
undetectable
4eatA-4u36A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wec SHORT CHAIN
DEHYDROGENASE


(Mycolicibacterium
smegmatis)
PF13561
(adh_short_C2)
4 ALA A  89
GLY A  20
GLY A  17
ILE A  14
NAD  A 301 ( 4.0A)
NAD  A 301 (-3.1A)
NAD  A 301 ( 4.8A)
None
0.64A 4eatA-4wecA:
4.2
4eatA-4wecA:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wv3 ANTHRANILATE-COA
LIGASE


(Stigmatella
aurantiaca)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
4 ALA A 293
ILE A 317
GLY A 318
ILE A 325
3UK  A 601 (-3.5A)
3UK  A 601 (-4.0A)
3UK  A 601 (-3.5A)
None
0.33A 4eatA-4wv3A:
57.4
4eatA-4wv3A:
42.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfl 1B2530 HEAVY CHAIN

(Homo sapiens)
no annotation 4 TYR H  54
GLY H  56
ILE H  51
ILE H  33
None
0.66A 4eatA-4yflH:
undetectable
4eatA-4yflH:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR


(Sphaerobacter
thermophilus)
PF13458
(Peripla_BP_6)
4 ALA A 151
GLY A 152
GLY A 370
ILE A 374
None
0.67A 4eatA-4zpjA:
5.4
4eatA-4zpjA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1


(Homo sapiens)
PF12859
(ANAPC1)
4 ALA A1389
ALA A1468
GLY A1467
ILE A1465
None
0.57A 4eatA-5a31A:
undetectable
4eatA-5a31A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hci GPN-LOOP GTPASE 1

(Saccharomyces
cerevisiae)
PF03029
(ATP_bind_1)
4 GLY A 109
ILE A 111
GLY A  10
ILE A   9
GDP  A 301 ( 4.4A)
None
None
None
0.67A 4eatA-5hciA:
undetectable
4eatA-5hciA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy7 TRANSCRIPTION
INITIATION FACTOR
IIB


(Homo sapiens)
PF00382
(TFIIB)
PF08271
(TF_Zn_Ribbon)
4 ALA M 256
ALA M 278
GLY M 275
ILE M 251
None
0.65A 4eatA-5iy7M:
undetectable
4eatA-5iy7M:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1


(Homo sapiens)
PF12859
(ANAPC1)
4 ALA A1389
ALA A1468
GLY A1467
ILE A1465
None
0.60A 4eatA-5lcwA:
undetectable
4eatA-5lcwA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly3 ACTIN/ACTIN FAMILY
PROTEIN


(Pyrobaculum
calidifontis)
PF00022
(Actin)
4 ALA A 130
GLY A 410
ILE A 408
GLY A 405
None
0.61A 4eatA-5ly3A:
undetectable
4eatA-5ly3A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 ALA A 506
GLY A 467
GLY A 472
ILE A 473
None
0.65A 4eatA-5nd5A:
undetectable
4eatA-5nd5A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3m PROTOCATECHUATE
DECARBOXYLASE


(Klebsiella
pneumoniae)
PF01977
(UbiD)
4 ALA A  77
GLY A  74
GLY A  55
ILE A  54
None
0.60A 4eatA-5o3mA:
2.7
4eatA-5o3mA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oe5 ANTHRANILATE--COA
LIGASE


(Pseudomonas
aeruginosa)
PF00501
(AMP-binding)
5 TYR A 211
ALA A 278
GLY A 279
ILE A 301
GLY A 302
3UK  A 900 (-4.0A)
3UK  A 900 ( 2.9A)
3UK  A 900 (-3.2A)
3UK  A 900 (-4.0A)
3UK  A 900 (-3.4A)
0.38A 4eatA-5oe5A:
49.3
4eatA-5oe5A:
28.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE


(Brucella canis)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
4 ALA A 250
TYR A 251
ALA A 322
GLY A 323
None
0.49A 4eatA-5u2aA:
43.0
4eatA-5u2aA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE


(Brucella canis)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
4 TYR A 251
ALA A 322
GLY A 323
GLY A 347
None
0.54A 4eatA-5u2aA:
43.0
4eatA-5u2aA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxu 11S GLOBULIN

(Wrightia
tinctoria)
no annotation 4 ALA A 170
ILE A 112
GLY A 111
ILE A 154
None
0.66A 4eatA-5wxuA:
undetectable
4eatA-5wxuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S4


(Trichomonas
vaginalis)
PF00900
(Ribosomal_S4e)
PF01479
(S4)
PF08071
(RS4NT)
PF16121
(40S_S4_C)
4 ALA E 119
GLY E  74
GLY E  91
ILE E  90
None
0.55A 4eatA-5xyiE:
undetectable
4eatA-5xyiE:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
SMALL SUBUNIT


(Methylobacillus
sp. KY4400)
no annotation 4 ALA A 155
ALA A 123
GLY A 124
ILE A 150
None
0.59A 4eatA-5y6qA:
undetectable
4eatA-5y6qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9y SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Paraburkholderia
phymatum)
no annotation 4 ALA A  92
GLY A  19
GLY A  16
ILE A  13
None
0.65A 4eatA-6d9yA:
3.3
4eatA-6d9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis)
no annotation 4 GLY A  73
ILE A  75
GLY A  76
ILE A  77
None
0.64A 4eatA-6eu6A:
undetectable
4eatA-6eu6A:
undetectable