SIMILAR PATTERNS OF AMINO ACIDS FOR 4EAH_F_ACTF402_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aih HP1 INTEGRASE

(Haemophilus
virus HP1) 		PF00589
(Phage_integrase) 		3 PHE A 255
ASP A 257
ARG A 253
 None
 0.80A 4eahF-1aihA:
0.0		 4eahF-1aihA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ava BARLEY
ALPHA-AMYLASE/SUBTIL
ISIN INHIBITOR

(Hordeum vulgare) 		PF00197
(Kunitz_legume) 		3 PHE C 163
ASP C  99
ARG C  41
 None
 0.89A 4eahF-1avaC:
undetectable		 4eahF-1avaC:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		3 PHE A 434
ASP A 515
ARG A 419
 None
 0.90A 4eahF-1crlA:
0.0		 4eahF-1crlA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eco ERYTHROCRUORIN
(CARBONMONOXY)

(Chironomus
thummi) 		PF00042
(Globin) 		3 PHE A 128
ASP A 126
ARG A 101
 None
 0.88A 4eahF-1ecoA:
undetectable		 4eahF-1ecoA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE
CUTM, FLAVOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava;
Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		3 PHE B 726
ASP B 724
ARG C 188
 None
 0.67A 4eahF-1ffvB:
0.0		 4eahF-1ffvB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 PHE A 301
ASP A 475
ARG A 169
 None
 0.79A 4eahF-1i7qA:
undetectable		 4eahF-1i7qA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		3 PHE A 265
ASP A 275
ARG A  85
 None
 0.79A 4eahF-1jmzA:
undetectable		 4eahF-1jmzA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdm C-ETS-1 PROTEIN

(Mus musculus) 		PF00178
(Ets) 		3 PHE B 363
ASP B 359
ARG B 413
 None
 0.52A 4eahF-1mdmB:
undetectable		 4eahF-1mdmB:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nar NARBONIN

(Vicia
narbonensis) 		PF00704
(Glyco_hydro_18) 		3 PHE A 205
ASP A 203
ARG A 248
 None
 0.89A 4eahF-1narA:
1.0		 4eahF-1narA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pie GALACTOKINASE

(Lactococcus
lactis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 PHE A  22
ASP A  24
ARG A  65
 None
 0.84A 4eahF-1pieA:
undetectable		 4eahF-1pieA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qox BETA-GLUCOSIDASE

(Bacillus
circulans) 		PF00232
(Glyco_hydro_1) 		3 PHE A 143
ASP A 141
ARG A 203
 None
 0.90A 4eahF-1qoxA:
undetectable		 4eahF-1qoxA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud3 AMYLASE

(Bacillus sp.
KSM-K38) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 PHE A 153
ASP A 142
ARG A 156
 None
 0.79A 4eahF-1ud3A:
1.1		 4eahF-1ud3A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5f PYRUVATE OXIDASE

(Aerococcus
viridans) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 PHE A 508
ASP A 515
ARG A 518
 None
 0.86A 4eahF-1v5fA:
undetectable		 4eahF-1v5fA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 PHE A 155
ASP A 144
ARG A 158
 None
 0.83A 4eahF-1w9xA:
1.7		 4eahF-1w9xA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9

(Arabidopsis
thaliana) 		PF02204
(VPS9) 		3 PHE A  61
ASP A  76
ARG A 215
 None
 0.83A 4eahF-2efeA:
undetectable		 4eahF-2efeA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiy PROTEIN FDHE HOMOLOG

(Pseudomonas
aeruginosa) 		PF04216
(FdhE) 		3 PHE A 266
ASP A 271
ARG A  35
 None
 0.89A 4eahF-2fiyA:
undetectable		 4eahF-2fiyA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6b RAS-RELATED PROTEIN
RAB-26

(Homo sapiens) 		PF00071
(Ras) 		3 PHE A 101
ASP A 119
ARG A 102
 None
MG  A 301 ( 3.9A)
None
 0.89A 4eahF-2g6bA:
2.0		 4eahF-2g6bA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdq YITF

(Bacillus
subtilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 PHE A 334
ASP A 328
ARG A  32
 None
 0.88A 4eahF-2gdqA:
undetectable		 4eahF-2gdqA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtl EXTRACELLULAR
HEMOGLOBIN LINKER L2
SUBUNIT

(Lumbricus
terrestris) 		PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C) 		3 PHE N 174
ASP N  79
ARG N 144
 None
 0.82A 4eahF-2gtlN:
undetectable		 4eahF-2gtlN:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iab HYPOTHETICAL PROTEIN

(Streptomyces
avermitilis) 		PF01243
(Putative_PNPOx) 		3 PHE A 105
ASP A 103
ARG A 114
 None
 0.76A 4eahF-2iabA:
undetectable		 4eahF-2iabA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyr UPF0341 PROTEIN YHIQ

(Shigella
flexneri) 		PF04445
(SAM_MT) 		3 PHE A 104
ASP A 102
ARG A  67
 None
SAH  A 301 (-3.4A)
None
 0.87A 4eahF-2oyrA:
undetectable		 4eahF-2oyrA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9g CYTOCHROME P450 46A1

(Homo sapiens) 		PF00067
(p450) 		3 PHE A 296
ASP A 294
ARG A 251
 None
 0.78A 4eahF-2q9gA:
undetectable		 4eahF-2q9gA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qbu PRECORRIN-2
METHYLTRANSFERASE

(Methanothermobacter
thermautotrophicus) 		PF00590
(TP_methylase) 		3 PHE A 162
ASP A 160
ARG A 183
 None
 0.90A 4eahF-2qbuA:
undetectable		 4eahF-2qbuA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7e COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		3 PHE B1743
ASP B1740
ARG B1776
 None
 0.87A 4eahF-2r7eB:
undetectable		 4eahF-2r7eB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5g YSCU

(Yersinia
enterocolitica) 		PF01312
(Bac_export_2) 		3 PHE A 285
ASP A 323
ARG A 256
 None
 0.59A 4eahF-2v5gA:
undetectable		 4eahF-2v5gA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wch GENERAL
ODORANT-BINDING
PROTEIN 1

(Bombyx mori) 		PF01395
(PBP_GOBP) 		3 PHE A  36
ASP A  39
ARG A 123
 B7M  A1145 ( 4.0A)
None
None
 0.87A 4eahF-2wchA:
undetectable		 4eahF-2wchA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1c ACYL-COENZYME

(Penicillium
chrysogenum) 		PF03417
(AAT) 		3 PHE A 279
ASP A 277
ARG A 241
 None
 0.78A 4eahF-2x1cA:
undetectable		 4eahF-2x1cA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 PHE A  87
ASP A 140
ARG A  90
 None
 0.70A 4eahF-2xaxA:
undetectable		 4eahF-2xaxA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfq NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Peptoniphilus
asaccharolyticus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 PHE A 157
ASP A 159
ARG A 126
 None
 0.86A 4eahF-2yfqA:
undetectable		 4eahF-2yfqA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2l HALOALKANE
DEHALOGENASE

(Bradyrhizobium
japonicum) 		PF00561
(Abhydrolase_1) 		3 PHE A  79
ASP A  86
ARG A 115
 None
 0.89A 4eahF-3a2lA:
1.1		 4eahF-3a2lA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5a HEMOGLOBIN V

(Tokunagayusurika
akamusi) 		PF00042
(Globin) 		3 PHE A 136
ASP A 134
ARG A 112
 None
 0.83A 4eahF-3a5aA:
undetectable		 4eahF-3a5aA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350

(Thermus
thermophilus) 		PF00582
(Usp) 		3 PHE A 126
ASP A 124
ARG A 258
 PHE  A 126 ( 1.3A)
ASP  A 124 ( 0.6A)
ARG  A 258 ( 0.6A)
 0.80A 4eahF-3ab7A:
undetectable		 4eahF-3ab7A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9w PUTATIVE
ACETYLTRANSFERASE

(Nocardia
farcinica) 		PF00797
(Acetyltransf_2) 		3 PHE A  27
ASP A  19
ARG A  31
 None
 0.86A 4eahF-3d9wA:
undetectable		 4eahF-3d9wA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebj POLYMERASE ACIDIC
PROTEIN

(Influenza A
virus) 		PF00603
(Flu_PA) 		3 PHE A 191
ASP A 189
ARG A 192
 None
 0.86A 4eahF-3ebjA:
undetectable		 4eahF-3ebjA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		3 PHE A 105
ASP A  61
ARG A 130
 None
 0.80A 4eahF-3f41A:
undetectable		 4eahF-3f41A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N) 		3 PHE A 362
ASP A 369
ARG A  79
 None
 0.89A 4eahF-3foaA:
undetectable		 4eahF-3foaA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 PHE A 527
ASP A 521
ARG A 428
 None
 0.87A 4eahF-3gg4A:
6.5		 4eahF-3gg4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifr CARBOHYDRATE KINASE,
FGGY

(Rhodospirillum
rubrum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 PHE A 485
ASP A 479
ARG A 388
 None
 0.84A 4eahF-3ifrA:
6.7		 4eahF-3ifrA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		3 PHE U 362
ASP U 369
ARG U  79
 None
 0.89A 4eahF-3j2nU:
1.2		 4eahF-3j2nU:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		3 PHE A 414
ASP A 543
ARG A  57
 None
 0.78A 4eahF-3j9dA:
undetectable		 4eahF-3j9dA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE

(Caenorhabditis
elegans) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 PHE A 304
ASP A 317
ARG A 295
 None
 0.72A 4eahF-3k6jA:
undetectable		 4eahF-3k6jA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Nostoc
punctiforme) 		PF00903
(Glyoxalase) 		3 PHE A 109
ASP A 151
ARG A 149
 None
 0.84A 4eahF-3kolA:
undetectable		 4eahF-3kolA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfu DNA HELICASE II

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		3 PHE A 111
ASP A 182
ARG A 195
 None
 0.81A 4eahF-3lfuA:
undetectable		 4eahF-3lfuA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln8 HYDROLASE

(Danio rerio) 		PF00074
(RnaseA) 		3 PHE A  52
ASP A  20
ARG A  25
 None
None
SO4  A3002 (-3.0A)
 0.80A 4eahF-3ln8A:
undetectable		 4eahF-3ln8A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 PHE A  53
ASP A  17
ARG A  21
 None
 0.84A 4eahF-3mosA:
undetectable		 4eahF-3mosA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oo3 OXY PROTEIN

(Actinoplanes
teichomyceticus) 		PF00067
(p450) 		3 PHE A 121
ASP A 119
ARG A 352
 None
 0.75A 4eahF-3oo3A:
undetectable		 4eahF-3oo3A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2c PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
ovatus) 		PF06824
(Glyco_hydro_125) 		3 PHE A 158
ASP A 160
ARG A 144
 None
 0.87A 4eahF-3p2cA:
undetectable		 4eahF-3p2cA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pss QNR

(Aeromonas
hydrophila) 		PF00805
(Pentapeptide)
PF13599
(Pentapeptide_4) 		3 PHE A  27
ASP A  49
ARG A  26
 None
 0.76A 4eahF-3pssA:
undetectable		 4eahF-3pssA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyr ECHA16_2

(Mycobacterium
avium) 		PF00378
(ECH_1) 		3 PHE A  36
ASP A  34
ARG A  82
 None
 0.89A 4eahF-3qyrA:
undetectable		 4eahF-3qyrA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r72 ODORANT BINDING
PROTEIN ASP5

(Apis mellifera) 		PF01395
(PBP_GOBP) 		3 PHE A 122
ASP A  32
ARG A  17
 NBB  A   1 (-4.7A)
None
None
 0.87A 4eahF-3r72A:
undetectable		 4eahF-3r72A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00342
(PGI) 		3 PHE A 410
ASP A  51
ARG A  54
 None
 0.75A 4eahF-3ujhA:
undetectable		 4eahF-3ujhA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voo FATTY ACID
ALPHA-HYDROXYLASE

(Sphingomonas
paucimobilis) 		PF00067
(p450) 		3 PHE A 332
ASP A 328
ARG A 336
 None
 0.88A 4eahF-3vooA:
undetectable		 4eahF-3vooA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE

(Caldanaerobius
polysaccharolyticus) 		PF00150
(Cellulase) 		3 PHE A 111
ASP A 109
ARG A 157
 None
 0.76A 4eahF-3w0kA:
undetectable		 4eahF-3w0kA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wu1 PROTEIN C-ETS-1

(Homo sapiens) 		PF00178
(Ets) 		3 PHE B 363
ASP B 359
ARG B 413
 None
 0.60A 4eahF-3wu1B:
undetectable		 4eahF-3wu1B:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbv COME

(Streptococcus
pneumoniae) 		PF00072
(Response_reg)
PF04397
(LytTR) 		3 PHE A 142
ASP A 140
ARG A 197
 None
 0.88A 4eahF-4cbvA:
undetectable		 4eahF-4cbvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dia 2-PYRONE-4,6-DICARBA
XYLATE HYDROLASE

(Sphingomonas
paucimobilis) 		PF04909
(Amidohydro_2) 		3 PHE A 228
ASP A 226
ARG A 270
 None
 0.74A 4eahF-4diaA:
undetectable		 4eahF-4diaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dtg HUMANIZED
RECOMBINANT FAB
FRAGMENT, FAB 2021,
OF A MURINE
ANTIBODY, HEAVY
CHAIN
TISSUE FACTOR
PATHWAY INHIBITOR

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF00014
(Kunitz_BPTI) 		3 PHE H  60
ASP H  62
ARG K  17
 None
 0.77A 4eahF-4dtgH:
undetectable		 4eahF-4dtgH:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		3 PHE A 427
ASP A 454
ARG A 494
 None
None
MLZ  A 625 ( 3.9A)
 0.88A 4eahF-4dwsA:
undetectable		 4eahF-4dwsA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Zea mays) 		PF00145
(DNA_methylase)
PF00385
(Chromo)
PF01426
(BAH) 		3 PHE A 687
ASP A 664
ARG A 828
 None
 0.88A 4eahF-4ft2A:
1.6		 4eahF-4ft2A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grc PUTATIVE MEMBRANE
PROTEIN

(Streptomyces
coelicolor) 		PF04261
(Dyp_perox) 		3 PHE A 362
ASP A 349
ARG A 177
 None
 0.88A 4eahF-4grcA:
undetectable		 4eahF-4grcA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF02811
(PHP) 		3 PHE A   9
ASP A 209
ARG A   6
 None
 0.85A 4eahF-4gx8A:
undetectable		 4eahF-4gx8A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 PHE A  67
ASP A  69
ARG A 498
 None
 0.89A 4eahF-4hvtA:
undetectable		 4eahF-4hvtA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 PHE A 237
ASP A 288
ARG A 261
 None
 0.80A 4eahF-4i3gA:
1.3		 4eahF-4i3gA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3u ALDEHYDE
DEHYDROGENASE (NAD+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		3 PHE A 307
ASP A 305
ARG A 395
 None
 0.86A 4eahF-4i3uA:
undetectable		 4eahF-4i3uA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6c CYTOCHROME P450
MONOOXYGENASE

(Nocardia
farcinica) 		PF00067
(p450) 		3 PHE A 337
ASP A 333
ARG A 341
 None
 0.82A 4eahF-4j6cA:
undetectable		 4eahF-4j6cA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 PHE A 443
ASP A 436
ARG A 418
 None
 0.77A 4eahF-4jgvA:
undetectable		 4eahF-4jgvA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjt ENOYL-COA HYDRATASE

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		3 PHE A  36
ASP A  34
ARG A  82
 None
 0.81A 4eahF-4jjtA:
1.4		 4eahF-4jjtA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnt ENVELOPE
GLYCOPROTEIN E2

(Pestivirus A) 		PF16329
(Pestivirus_E2) 		3 PHE A 791
ASP A 789
ARG A 850
 None
 0.72A 4eahF-4jntA:
undetectable		 4eahF-4jntA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2a HALOALKANE
DEHALOGENASE

(Bradyrhizobium
elkanii) 		PF00561
(Abhydrolase_1) 		3 PHE A  79
ASP A  86
ARG A 115
 None
 0.87A 4eahF-4k2aA:
undetectable		 4eahF-4k2aA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		3 PHE A 295
ASP A 293
ARG A 386
 None
 0.77A 4eahF-4knaA:
undetectable		 4eahF-4knaA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1

(Archaeoglobus
fulgidus) 		PF01867
(Cas_Cas1) 		3 PHE A 341
ASP A 327
ARG A 311
 None
 0.90A 4eahF-4n06A:
undetectable		 4eahF-4n06A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY

(Yersinia
frederiksenii) 		PF01758
(SBF) 		3 PHE A 243
ASP A 118
ARG A  60
 None
 0.87A 4eahF-4n7wA:
undetectable		 4eahF-4n7wA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuh ICE-BINDING PROTEIN

(Leucosporidium) 		PF11999
(DUF3494) 		3 PHE A  91
ASP A  93
ARG A   3
 None
 0.74A 4eahF-4nuhA:
undetectable		 4eahF-4nuhA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmd ENDO-1,4-BETA-XYLANA
SE

(Caldicellulosiruptor
bescii) 		PF00331
(Glyco_hydro_10) 		3 PHE A 100
ASP A 102
ARG A 115
 None
 0.78A 4eahF-4pmdA:
undetectable		 4eahF-4pmdA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rav SINGLE-CHAIN FV, VH
SINGLE-CHAIN FV, VL

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		3 PHE B 220
ASP B 179
ARG A 100
 None
 0.87A 4eahF-4ravB:
undetectable		 4eahF-4ravB:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL

(Plasmodium
berghei) 		no annotation 3 PHE A  61
ASP A  59
ARG A 113
 None
 0.79A 4eahF-4u5aA:
undetectable		 4eahF-4u5aA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u LINKER L2

(Glossoscolex
paulistus) 		PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C) 		3 PHE N 181
ASP N  86
ARG N 151
 None
 0.43A 4eahF-4u8uN:
undetectable		 4eahF-4u8uN:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		3 PHE A 545
ASP A 548
ARG A 552
 None
 0.71A 4eahF-4wxxA:
undetectable		 4eahF-4wxxA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chl VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 72 HOMOLOG
HISTONE H2A.Z

(Drosophila
melanogaster;
Homo sapiens) 		PF05764
(YL1)
PF00125
(Histone)
PF16211
(Histone_H2A_C) 		3 PHE A  29
ASP A  27
ARG B 165
 None
 0.90A 4eahF-5chlA:
undetectable		 4eahF-5chlA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1r RV1816
TRANSCRIPTIONAL
REGULATOR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		3 PHE A 142
ASP A 144
ARG A  83
 56S  A 305 (-4.1A)
None
None
 0.84A 4eahF-5d1rA:
undetectable		 4eahF-5d1rA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		3 PHE A 374
ASP A 370
ARG A 378
 None
 0.80A 4eahF-5e78A:
undetectable		 4eahF-5e78A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejj UFM1-SPECIFIC
PROTEASE

(Caenorhabditis
elegans) 		PF07910
(Peptidase_C78) 		3 PHE A  75
ASP A  67
ARG A 332
 None
 0.88A 4eahF-5ejjA:
undetectable		 4eahF-5ejjA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3

(Homo sapiens) 		PF00171
(Aldedh) 		3 PHE A 126
ASP A 348
ARG A  25
 None
 0.79A 4eahF-5fhzA:
undetectable		 4eahF-5fhzA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 3 PHE A 714
ASP A 685
ARG A 711
 None
 0.84A 4eahF-5fkrA:
undetectable		 4eahF-5fkrA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnc AVH146

(Phytophthora
sojae) 		no annotation 3 PHE A 460
ASP A 458
ARG A 505
 None
 0.85A 4eahF-5gncA:
undetectable		 4eahF-5gncA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE

([Eubacterium]
rectale) 		PF00078
(RVT_1) 		3 PHE A 106
ASP A 108
ARG A 117
 None
 0.75A 4eahF-5hhlA:
undetectable		 4eahF-5hhlA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 PHE B1047
ASP B1049
ARG B 730
 None
 0.86A 4eahF-5ip9B:
undetectable		 4eahF-5ip9B:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6b ALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		3 PHE A 405
ASP A 402
ARG A 377
 None
 0.86A 4eahF-5j6bA:
undetectable		 4eahF-5j6bA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		3 PHE A 405
ASP A 402
ARG A 377
 None
 0.86A 4eahF-5jryA:
undetectable		 4eahF-5jryA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		3 PHE A 681
ASP A 652
ARG A 678
 None
 0.87A 4eahF-5jwzA:
undetectable		 4eahF-5jwzA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 PHE A 673
ASP A 735
ARG A 697
 None
 0.86A 4eahF-5k6oA:
undetectable		 4eahF-5k6oA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kei 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 PHE A 183
ASP A 179
ARG A 158
 None
 0.78A 4eahF-5keiA:
undetectable		 4eahF-5keiA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsk KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
CENTROMERE PROTEIN C

(Homo sapiens;
Homo sapiens) 		PF08641
(Mis14)
PF15622
(CENP_C_N) 		3 PHE N 115
ASP N 113
ARG P  15
 None
 0.81A 4eahF-5lskN:
undetectable		 4eahF-5lskN:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC

(Flaveria
trinervia) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 PHE A 766
ASP A 853
ARG A 823
 None
 0.90A 4eahF-5lu4A:
1.0		 4eahF-5lu4A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwl INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Mus musculus) 		PF06090
(Ins_P5_2-kin) 		3 PHE A  58
ASP A 360
ARG A 393
 None
 0.74A 4eahF-5mwlA:
undetectable		 4eahF-5mwlA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7z LIPOPOLYSACCHARIDE
1,6-GALACTOSYLTRANSF
ERASE

(Salmonella
enterica) 		no annotation 3 PHE A 314
ASP A 312
ARG A 206
 None
 0.85A 4eahF-5n7zA:
undetectable		 4eahF-5n7zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nva PUTATIVE
SODIUM:SOLUTE
SYMPORTER

(Proteus
mirabilis) 		no annotation 3 PHE A  28
ASP A  37
ARG A  44
 None
 0.75A 4eahF-5nvaA:
undetectable		 4eahF-5nvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t86 CDIA TOXIN
CDII IMMUNITY
PROTEIN

(Escherichia
coli;
Escherichia
coli) 		no annotation
no annotation 		3 PHE I 113
ASP I  72
ARG A 207
 None
 0.90A 4eahF-5t86I:
undetectable		 4eahF-5t86I:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zry ANKYRIN REPEAT AND
SAM
DOMAIN-CONTAINING
PROTEIN 1A,EPHRIN
TYPE-A RECEPTOR 6

(Mus musculus) 		no annotation 3 PHE A  58
ASP A  60
ARG A 173
 None
 0.84A 4eahF-5zryA:
undetectable		 4eahF-5zryA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f72 MTVAO615

(Thermothelomyces
thermophila) 		no annotation 3 PHE A 453
ASP A 335
ARG A 420
 None
 0.89A 4eahF-6f72A:
undetectable		 4eahF-6f72A:
undetectable