SIMILAR PATTERNS OF AMINO ACIDS FOR 4EAH_E_ACTE1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		4 THR A 274
GLN A 430
GLU A 474
ARG A 437
 None
 1.47A 4eahA-3ayxA:
0.5
4eahD-3ayxA:
0.0
4eahE-3ayxA:
1.4		 4eahA-3ayxA:
20.92
4eahD-3ayxA:
20.30
4eahE-3ayxA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 THR A 724
GLN A 670
GLU A 678
ARG A 682
 None
 1.38A 4eahA-4aipA:
undetectable
4eahD-4aipA:
0.0
4eahE-4aipA:
undetectable		 4eahA-4aipA:
19.79
4eahD-4aipA:
18.70
4eahE-4aipA:
19.79