SIMILAR PATTERNS OF AMINO ACIDS FOR 4EAH_C_ACTC1002

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq5 DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 1

(Homo sapiens) 		PF00106
(adh_short) 		4 ARG A  21
GLN A  26
GLU A 230
THR A 229
 None
 1.24A 4eahC-2qq5A:
1.4
4eahH-2qq5A:
3.0		 4eahC-2qq5A:
20.10
4eahH-2qq5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA

(Mycobacterium
tuberculosis) 		PF16708
(LppA) 		4 ARG A 118
GLN A 169
GLU A 174
THR A 188
 None
 1.33A 4eahC-2v7sA:
1.3
4eahH-2v7sA:
0.0		 4eahC-2v7sA:
21.54
4eahH-2v7sA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvr INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		4 ARG A  68
GLN A  65
GLU A  86
THR A  88
 None
 1.34A 4eahC-3cvrA:
2.3
4eahH-3cvrA:
0.0		 4eahC-3cvrA:
24.35
4eahH-3cvrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcs RACEMASE, PUTATIVE

(Roseobacter
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A  79
GLN A  46
GLU A  70
THR A  67
 None
 1.37A 4eahC-3tcsA:
0.0
4eahH-3tcsA:
0.5		 4eahC-3tcsA:
22.39
4eahH-3tcsA:
23.06