SIMILAR PATTERNS OF AMINO ACIDS FOR 4EAH_B_ACTB1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atj PEROXIDASE C1A

(Armoracia
rusticana) 		PF00141
(peroxidase) 		4 VAL A 235
ASN A 231
ASN A 236
ARG A 224
 None
 1.20A 4eahB-1atjA:
0.0
4eahC-1atjA:
0.0		 4eahB-1atjA:
21.36
4eahC-1atjA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7p FN1 PROTEIN

(Homo sapiens) 		PF00039
(fn1)
PF00040
(fn2) 		4 VAL A 527
ASN A 526
ASN A 473
ARG A 534
 None
None
None
NAG  A1528 ( 4.8A)
 1.44A 4eahB-3m7pA:
undetectable
4eahC-3m7pA:
undetectable		 4eahB-3m7pA:
17.85
4eahC-3m7pA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aog CATIONIC PEROXIDASE
SPC4

(Sorghum bicolor) 		PF00141
(peroxidase) 		4 VAL A 270
ASN A 266
ASN A 271
ARG A 259
 None
None
None
NAG  A1347 ( 4.8A)
 1.29A 4eahB-5aogA:
0.0
4eahC-5aogA:
0.0		 4eahB-5aogA:
22.33
4eahC-5aogA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 VAL A 492
ASN A 460
ASN A 509
ARG A 548
 None
 1.42A 4eahB-5fp1A:
0.0
4eahC-5fp1A:
0.0		 4eahB-5fp1A:
20.53
4eahC-5fp1A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmt ALGINATE LYASE

(Aplysia kurodai) 		no annotation 4 VAL A 191
ASN A 221
ASN A 189
ARG A 220
 None
 1.36A 4eahB-5gmtA:
undetectable
4eahC-5gmtA:
undetectable		 4eahB-5gmtA:
19.90
4eahC-5gmtA:
19.90