SIMILAR PATTERNS OF AMINO ACIDS FOR 4E7G_A_ACTA514_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1idu | VANADIUMCHLOROPEROXIDASE (Curvulariainaequalis) |
PF01569(PAP2) | 4 | ALA A 234VAL A 340ASP A 344LEU A 173 | None | 1.34A | 4e7gA-1iduA:0.0 | 4e7gA-1iduA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jlv | GLUTATHIONETRANSFERASE GST1-3 (Anophelescracens) |
PF00043(GST_C)PF02798(GST_N) | 4 | ALA A 155VAL A 159ASP A 156LEU A 141 | None | 0.81A | 4e7gA-1jlvA:0.0 | 4e7gA-1jlvA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m0v | PROTEIN-TYROSINEPHOSPHATASE YOPH (Yersiniapseudotuberculosis) |
PF09013(YopH_N) | 4 | ALA A 119VAL A 115ASP A 72LEU A 90 | None | 1.32A | 4e7gA-1m0vA:0.4 | 4e7gA-1m0vA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m22 | PEPTIDE AMIDASE (Stenotrophomonasmaltophilia) |
PF01425(Amidase) | 4 | ALA A 265VAL A 217ASP A 270LEU A 115 | None | 1.49A | 4e7gA-1m22A:0.2 | 4e7gA-1m22A:24.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o54 | SAM-DEPENDENTO-METHYLTRANSFERASE (Thermotogamaritima) |
PF08704(GCD14) | 4 | ALA A 130VAL A 128ASP A 106LEU A 145 | None | 1.43A | 4e7gA-1o54A:2.2 | 4e7gA-1o54A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p4s | ADENYLATE KINASE (Mycobacteriumtuberculosis) |
PF00406(ADK) | 4 | ALA A 109VAL A 3ASP A 108LEU A 20 | None | 1.15A | 4e7gA-1p4sA:0.0 | 4e7gA-1p4sA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p4s | ADENYLATE KINASE (Mycobacteriumtuberculosis) |
PF00406(ADK) | 4 | ALA A 109VAL A 3ASP A 108LEU A 24 | None | 1.16A | 4e7gA-1p4sA:0.0 | 4e7gA-1p4sA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ph5 | TELOMERE-BINDINGPROTEIN ALPHASUBUNIT (Sterkiella nova) |
PF02765(POT1) | 4 | ALA A 228VAL A 226ASP A 247LEU A 288 | None | 1.40A | 4e7gA-1ph5A:0.0 | 4e7gA-1ph5A:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sg4 | 3,2-TRANS-ENOYL-COAISOMERASE,MITOCHONDRIAL (Homo sapiens) |
PF00378(ECH_1) | 4 | ALA A 13VAL A 15ASP A 10LEU A 195 | None | 0.86A | 4e7gA-1sg4A:0.0 | 4e7gA-1sg4A:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ssq | SERINEACETYLTRANSFERASE (Haemophilusinfluenzae) |
PF00132(Hexapep)PF06426(SATase_N) | 4 | ALA A 90VAL A 91ASP A 88LEU A 101 | CYS A2000 (-3.5A)NoneCYS A2000 (-3.1A)None | 0.95A | 4e7gA-1ssqA:0.0 | 4e7gA-1ssqA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3d | SERINEACETYLTRANSFERASE (Escherichiacoli) |
PF00132(Hexapep)PF06426(SATase_N) | 4 | ALA A 94VAL A 95ASP A 92LEU A 105 | None | 0.97A | 4e7gA-1t3dA:undetectable | 4e7gA-1t3dA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t47 | 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE (Streptomycesavermitilis) |
PF00903(Glyoxalase) | 4 | ALA A 104VAL A 154ASP A 24LEU A 164 | None | 1.08A | 4e7gA-1t47A:undetectable | 4e7gA-1t47A:23.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g29 | NITRATE TRANSPORTPROTEIN NRTA (Synechocystissp.) |
PF13379(NMT1_2) | 4 | ALA A 275VAL A 278ASP A 279LEU A 395 | None | 0.93A | 4e7gA-2g29A:0.3 | 4e7gA-2g29A:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hnl | GLUTATHIONES-TRANSFERASE 1 (Onchocercavolvulus) |
PF02798(GST_N)PF14497(GST_C_3) | 4 | ALA A 177VAL A 181ASP A 178LEU A 161 | None | 0.93A | 4e7gA-2hnlA:undetectable | 4e7gA-2hnlA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i4c | BICARBONATETRANSPORTER (Synechocystissp. PCC 6803) |
PF13379(NMT1_2) | 4 | ALA A 277VAL A 280ASP A 281LEU A 404 | None | 0.94A | 4e7gA-2i4cA:undetectable | 4e7gA-2i4cA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jky | HYPOXANTHINE-GUANINEPHOSPHORIBOSYLTRANSFERASE (Saccharomycescerevisiae) |
PF00156(Pribosyltran) | 4 | ALA A 180VAL A 155ASP A 158LEU A 119 | None | 1.36A | 4e7gA-2jkyA:undetectable | 4e7gA-2jkyA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v26 | MYOSIN VI (Sus scrofa) |
PF00063(Myosin_head) | 4 | ALA A 91VAL A 90ASP A 61LEU A 68 | None | 1.00A | 4e7gA-2v26A:undetectable | 4e7gA-2v26A:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3any | ETHANOLAMINEAMMONIA-LYASE HEAVYCHAIN (Escherichiacoli) |
PF06751(EutB) | 4 | ALA A 344VAL A 327ASP A 348LEU A 383 | None | 1.33A | 4e7gA-3anyA:undetectable | 4e7gA-3anyA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bmw | CYCLOMALTODEXTRINGLUCANOTRANSFERASE (Thermoanaerobacteriumthermosulfurigenes) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG) | 4 | ALA A 488VAL A 489ASP A 458LEU A 394 | None | 1.27A | 4e7gA-3bmwA:undetectable | 4e7gA-3bmwA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dd6 | RIBONUCLEASE PH (Bacillusanthracis) |
PF01138(RNase_PH)PF03725(RNase_PH_C) | 4 | ALA A 184VAL A 186ASP A 187LEU A 218 | None | 1.43A | 4e7gA-3dd6A:undetectable | 4e7gA-3dd6A:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gvd | SERINEACETYLTRANSFERASE (Yersinia pestis) |
PF00132(Hexapep)PF06426(SATase_N) | 4 | ALA A 94VAL A 95ASP A 92LEU A 105 | CYS A 276 (-3.5A)NoneCYS A 276 (-2.7A)None | 0.93A | 4e7gA-3gvdA:undetectable | 4e7gA-3gvdA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gxk | GOOSE-TYPE LYSOZYME1 (Gadus morhua) |
PF01464(SLT) | 4 | ALA A 64VAL A 65ASP A 62LEU A 144 | None | 1.32A | 4e7gA-3gxkA:undetectable | 4e7gA-3gxkA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ibh | SACCHAROMYCESCEREVISIAE GTT2 (Saccharomycescerevisiae) |
PF00043(GST_C)PF13417(GST_N_3) | 4 | ALA A 184VAL A 188ASP A 185LEU A 170 | None | 0.86A | 4e7gA-3ibhA:undetectable | 4e7gA-3ibhA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icx | PRE MRNA SPLICINGPROTEIN (Sulfolobussolfataricus) |
PF01798(Nop) | 4 | ALA A 348VAL A 265ASP A 352LEU A 278 | None | 1.46A | 4e7gA-3icxA:undetectable | 4e7gA-3icxA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k30 | HISTAMINEDEHYDROGENASE (Pimelobactersimplex) |
PF00724(Oxidored_FMN)PF07992(Pyr_redox_2) | 4 | ALA A 500VAL A 493ASP A 491LEU A 623 | None | 1.31A | 4e7gA-3k30A:undetectable | 4e7gA-3k30A:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3muu | STRUCTURALPOLYPROTEIN (Sindbis virus) |
PF00943(Alpha_E2_glycop)PF01589(Alpha_E1_glycop) | 4 | ALA A 38VAL A 154ASP A 40LEU A 102 | None | 1.41A | 4e7gA-3muuA:undetectable | 4e7gA-3muuA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rc2 | SUGAR3-KETOREDUCTASE (Actinomadurakijaniata) |
PF01408(GFO_IDH_MocA) | 4 | ALA A 316VAL A 319ASP A 320LEU A 181 | None | 1.12A | 4e7gA-3rc2A:1.4 | 4e7gA-3rc2A:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sim | PROTEIN, FAMILY 18CHITINASE (Crocus vernus) |
PF00704(Glyco_hydro_18) | 4 | ALA A 255VAL A 15ASP A 256LEU A 61 | None | 1.17A | 4e7gA-3simA:0.7 | 4e7gA-3simA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sum | CERATO-PLATANIN-LIKEPROTEIN (Moniliophthoraperniciosa) |
PF07249(Cerato-platanin) | 4 | ALA A 72VAL A 98ASP A 99LEU A 61 | None | 1.23A | 4e7gA-3sumA:undetectable | 4e7gA-3sumA:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tat | TYROSINEAMINOTRANSFERASE (Escherichiacoli) |
PF00155(Aminotran_1_2) | 4 | ALA A 367VAL A 370ASP A 371LEU A 20 | None | 0.80A | 4e7gA-3tatA:undetectable | 4e7gA-3tatA:24.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tot | GLUTATHIONES-TRANSFERASEPROTEIN (Ralstoniasolanacearum) |
PF13410(GST_C_2)PF13417(GST_N_3) | 4 | ALA A 158VAL A 162ASP A 159LEU A 144 | None | 0.96A | 4e7gA-3totA:undetectable | 4e7gA-3totA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wi3 | DNA REPLICATIONREGULATOR SLD3 (Saccharomycescerevisiae) |
PF08639(SLD3) | 4 | ALA A 260VAL A 264ASP A 261LEU A 357 | EDO A 515 ( 3.3A)EDO A 514 ( 3.2A)NoneNone | 1.19A | 4e7gA-3wi3A:undetectable | 4e7gA-3wi3A:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wyh | LYSOZYME G (Struthiocamelus) |
PF01464(SLT) | 4 | ALA A 64VAL A 65ASP A 62LEU A 140 | None | 1.25A | 4e7gA-3wyhA:undetectable | 4e7gA-3wyhA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4anj | UNCONVENTIONALMYOSIN-VI, GREENFLUORESCENT PROTEIN (Aequoreavictoria;Sus scrofa) |
PF00063(Myosin_head)PF01353(GFP) | 4 | ALA A 91VAL A 90ASP A 61LEU A 68 | None | 1.03A | 4e7gA-4anjA:undetectable | 4e7gA-4anjA:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cca | SYNTAXIN-BINDINGPROTEIN 2 (Homo sapiens) |
PF00995(Sec1) | 4 | ALA A 397VAL A 398ASP A 395LEU A 364 | None | 1.32A | 4e7gA-4ccaA:2.7 | 4e7gA-4ccaA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cgt | CYCLODEXTRINGLYCOSYLTRANSFERASE (Bacilluscirculans) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 4 | ALA A 487VAL A 488ASP A 458LEU A 394 | None | 1.26A | 4e7gA-4cgtA:undetectable | 4e7gA-4cgtA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dwe | UNCHARACTERIZEDPROTEIN (Bacteroidesovatus) |
PF15421(Polysacc_deac_3) | 4 | ALA A 234VAL A 233ASP A 168LEU A 217 | None | 1.28A | 4e7gA-4dweA:undetectable | 4e7gA-4dweA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4glt | GLUTATHIONES-TRANSFERASE-LIKEPROTEIN (Methylobacillusflagellatus) |
PF13410(GST_C_2)PF13417(GST_N_3) | 4 | ALA A 155VAL A 159ASP A 156LEU A 141 | None | 0.75A | 4e7gA-4gltA:undetectable | 4e7gA-4gltA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h7o | SERINEACETYLTRANSFERASE (Vibrio cholerae) |
PF00132(Hexapep)PF06426(SATase_N) | 4 | ALA A 94VAL A 95ASP A 92LEU A 105 | CYS A 303 ( 3.7A)NoneCYS A 303 (-2.9A)None | 0.92A | 4e7gA-4h7oA:undetectable | 4e7gA-4h7oA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4het | HYPOTHETICALGLYCOSIDE HYDROLASE (Bacteroidesthetaiotaomicron) |
PF13201(PCMD) | 4 | ALA A 59VAL A 55ASP A 38LEU A 66 | None | 1.15A | 4e7gA-4hetA:undetectable | 4e7gA-4hetA:24.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9w | PROLINE RACEMASEFAMILY PROTEIN (Pseudomonasprotegens) |
PF05544(Pro_racemase) | 4 | ALA A 294VAL A 6ASP A 8LEU A 59 | None | 1.44A | 4e7gA-4j9wA:undetectable | 4e7gA-4j9wA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jrl | PUTATIVE GLYCOSIDEHYDROLASE (Bacteroidesovatus) |
PF13201(PCMD) | 4 | ALA A 59VAL A 55ASP A 38LEU A 66 | GOL A 407 (-3.2A)GOL A 407 ( 4.9A)GOL A 407 (-4.0A)None | 1.17A | 4e7gA-4jrlA:undetectable | 4e7gA-4jrlA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kf9 | GLUTATHIONES-TRANSFERASEPROTEIN (Ralstoniasolanacearum) |
PF13410(GST_C_2)PF13417(GST_N_3) | 4 | ALA A 185VAL A 189ASP A 186LEU A 165 | None | 1.11A | 4e7gA-4kf9A:undetectable | 4e7gA-4kf9A:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l8e | GLUTATHIONES-TRANSFERASE ENZYMEWITHTHIOREDOXIN-LIKEDOMAIN (Xenorhabdusnematophila) |
PF00043(GST_C)PF02798(GST_N) | 4 | ALA A 167VAL A 171ASP A 168LEU A 153 | None | 0.94A | 4e7gA-4l8eA:undetectable | 4e7gA-4l8eA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4me2 | UNCHARACTERIZEDPROTEIN (Brachypodiumdistachyon) |
no annotation | 4 | ALA A 136VAL A 139ASP A 140LEU A 178 | None | 0.98A | 4e7gA-4me2A:undetectable | 4e7gA-4me2A:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mk3 | GLUTATHIONES-TRANSFERASE (Cupriavidusmetallidurans) |
PF13410(GST_C_2)PF13417(GST_N_3) | 4 | ALA A 156VAL A 160ASP A 157LEU A 142 | None | 0.97A | 4e7gA-4mk3A:undetectable | 4e7gA-4mk3A:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oer | NIKA PROTEIN (Brucella suis) |
PF00496(SBP_bac_5) | 4 | ALA A 262VAL A 263ASP A 260LEU A 338 | None | 1.23A | 4e7gA-4oerA:undetectable | 4e7gA-4oerA:24.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4okd | ISOAMYLASE (Chlamydomonasreinhardtii) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 4 | ALA A 496VAL A 498ASP A 494LEU A 504 | None | 0.97A | 4e7gA-4okdA:undetectable | 4e7gA-4okdA:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4poo | PUTATIVE RNAMETHYLASE (Bacillussubtilis) |
PF06962(rRNA_methylase) | 4 | ALA A 50VAL A 48ASP A 26LEU A 65 | NoneNoneSAM A 301 ( 4.6A)None | 1.40A | 4e7gA-4pooA:4.2 | 4e7gA-4pooA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pv4 | PROLINEAMINOPEPTIDASE P II (Yersinia pestis) |
PF00557(Peptidase_M24)PF05195(AMP_N) | 4 | ALA A 135VAL A 139ASP A 136LEU A 160 | NoneNoneNoneEDO A 505 (-4.9A) | 1.20A | 4e7gA-4pv4A:undetectable | 4e7gA-4pv4A:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ras | OXIDOREDUCTASE,NAD-BINDING/IRON-SULFUR CLUSTER-BINDINGPROTEIN (Nitratireductorpacificus) |
PF12838(Fer4_7)PF13486(Dehalogenase) | 4 | ALA A 438VAL A 435ASP A 49LEU A 359 | None | 1.18A | 4e7gA-4rasA:undetectable | 4e7gA-4rasA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v3l | E3 UBIQUITIN-PROTEINLIGASE RNF38 (Homo sapiens) |
PF13639(zf-RING_2) | 4 | ALA C 437VAL C 440ASP C 441LEU C 429 | None | 1.05A | 4e7gA-4v3lC:undetectable | 4e7gA-4v3lC:11.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zxg | GLUTATHIONES-TRANSFERASE (Plasmodiumfalciparum) |
PF02798(GST_N)PF14497(GST_C_3) | 4 | ALA A 161VAL A 165ASP A 162LEU A 139 | None | 0.87A | 4e7gA-4zxgA:undetectable | 4e7gA-4zxgA:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a22 | VESICULAR STOMATITISVIRUS L POLYMERASE (Vesicularstomatitisvirus) |
PF00946(Mononeg_RNA_pol)PF14314(Methyltrans_Mon)PF14318(Mononeg_mRNAcap) | 4 | ALA A 578VAL A 579ASP A 574LEU A 710 | None | 1.34A | 4e7gA-5a22A:undetectable | 4e7gA-5a22A:11.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dhm | IMMUNOREACTIVE 32KDA ANTIGEN (Porphyromonasgingivalis) |
no annotation | 4 | ALA C 123VAL C 124ASP C 121LEU C 157 | None | 1.47A | 4e7gA-5dhmC:undetectable | 4e7gA-5dhmC:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dqs | ELONGATION FACTOR1-GAMMA (Homo sapiens) |
PF00043(GST_C)PF02798(GST_N) | 4 | ALA A 160VAL A 164ASP A 161LEU A 146 | None | 1.03A | 4e7gA-5dqsA:undetectable | 4e7gA-5dqsA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gai | PEPTIDOGLYCANHYDROLASE GP4 (Salmonellavirus P22) |
PF11650(P22_Tail-4) | 4 | ALA K 97VAL K 28ASP K 31LEU K 18 | None | 1.22A | 4e7gA-5gaiK:undetectable | 4e7gA-5gaiK:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h7w | VENOM5'-NUCLEOTIDASE (Naja atra) |
no annotation | 4 | ALA A 319VAL A 320ASP A 317LEU A 108 | None | 1.04A | 4e7gA-5h7wA:undetectable | 4e7gA-5h7wA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tzy | FREE FATTY ACIDRECEPTOR1,ENDOLYSIN,FREEFATTY ACID RECEPTOR1 (Homo sapiens;Escherichiavirus T4) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 4 | ALA A1074VAL A1071ASP A1070LEU A1007 | None | 1.14A | 4e7gA-5tzyA:undetectable | 4e7gA-5tzyA:25.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wyp | DNA POLYMERASE IIISUBUNIT BETA (Caulobactervibrioides) |
no annotation | 4 | ALA A 13VAL A 17ASP A 55LEU A 212 | None | 1.47A | 4e7gA-5wypA:undetectable | 4e7gA-5wypA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x2v | L-METHIONINEGAMMA-LYASE (Pseudomonasputida) |
PF01053(Cys_Met_Meta_PP) | 4 | ALA A 393VAL A 390ASP A 389LEU A 376 | None | 1.11A | 4e7gA-5x2vA:undetectable | 4e7gA-5x2vA:25.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bs7 | ADENYLOSUCCINATESYNTHETASE (Legionellapneumophila) |
no annotation | 4 | ALA A 345VAL A 314ASP A 312LEU A 369 | None | 1.13A | 4e7gA-6bs7A:1.0 | 4e7gA-6bs7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f4f | GLUTATHIONETRANSFERASE (Trametesversicolor) |
no annotation | 4 | ALA A 161VAL A 165ASP A 162LEU A 147 | None | 0.97A | 4e7gA-6f4fA:undetectable | 4e7gA-6f4fA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f71 | GLUTATHIONETRANSFERASE (Trametesversicolor) |
no annotation | 4 | ALA A 164VAL A 168ASP A 165LEU A 149 | None | 0.95A | 4e7gA-6f71A:undetectable | 4e7gA-6f71A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6req | PROTEIN(METHYLMALONYL-COAMUTASE) (Propionibacteriumfreudenreichii) |
PF01642(MM_CoA_mutase) | 4 | ALA B 454VAL B 623ASP B 622LEU B 500 | None | 1.32A | 4e7gA-6reqB:1.3 | 4e7gA-6reqB:22.59 |