SIMILAR PATTERNS OF AMINO ACIDS FOR 4E7G_A_ACTA514

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE


(Curvularia
inaequalis)
PF01569
(PAP2)
4 ALA A 234
VAL A 340
ASP A 344
LEU A 173
None
1.34A 4e7gA-1iduA:
0.0
4e7gA-1iduA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jlv GLUTATHIONE
TRANSFERASE GST1-3


(Anopheles
cracens)
PF00043
(GST_C)
PF02798
(GST_N)
4 ALA A 155
VAL A 159
ASP A 156
LEU A 141
None
0.81A 4e7gA-1jlvA:
0.0
4e7gA-1jlvA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0v PROTEIN-TYROSINE
PHOSPHATASE YOPH


(Yersinia
pseudotuberculosis)
PF09013
(YopH_N)
4 ALA A 119
VAL A 115
ASP A  72
LEU A  90
None
1.32A 4e7gA-1m0vA:
0.4
4e7gA-1m0vA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m22 PEPTIDE AMIDASE

(Stenotrophomonas
maltophilia)
PF01425
(Amidase)
4 ALA A 265
VAL A 217
ASP A 270
LEU A 115
None
1.49A 4e7gA-1m22A:
0.2
4e7gA-1m22A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE


(Thermotoga
maritima)
PF08704
(GCD14)
4 ALA A 130
VAL A 128
ASP A 106
LEU A 145
None
1.43A 4e7gA-1o54A:
2.2
4e7gA-1o54A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4s ADENYLATE KINASE

(Mycobacterium
tuberculosis)
PF00406
(ADK)
4 ALA A 109
VAL A   3
ASP A 108
LEU A  20
None
1.15A 4e7gA-1p4sA:
0.0
4e7gA-1p4sA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4s ADENYLATE KINASE

(Mycobacterium
tuberculosis)
PF00406
(ADK)
4 ALA A 109
VAL A   3
ASP A 108
LEU A  24
None
1.16A 4e7gA-1p4sA:
0.0
4e7gA-1p4sA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ph5 TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT


(Sterkiella nova)
PF02765
(POT1)
4 ALA A 228
VAL A 226
ASP A 247
LEU A 288
None
1.40A 4e7gA-1ph5A:
0.0
4e7gA-1ph5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL


(Homo sapiens)
PF00378
(ECH_1)
4 ALA A  13
VAL A  15
ASP A  10
LEU A 195
None
0.86A 4e7gA-1sg4A:
0.0
4e7gA-1sg4A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ssq SERINE
ACETYLTRANSFERASE


(Haemophilus
influenzae)
PF00132
(Hexapep)
PF06426
(SATase_N)
4 ALA A  90
VAL A  91
ASP A  88
LEU A 101
CYS  A2000 (-3.5A)
None
CYS  A2000 (-3.1A)
None
0.95A 4e7gA-1ssqA:
0.0
4e7gA-1ssqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3d SERINE
ACETYLTRANSFERASE


(Escherichia
coli)
PF00132
(Hexapep)
PF06426
(SATase_N)
4 ALA A  94
VAL A  95
ASP A  92
LEU A 105
None
0.97A 4e7gA-1t3dA:
undetectable
4e7gA-1t3dA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE


(Streptomyces
avermitilis)
PF00903
(Glyoxalase)
4 ALA A 104
VAL A 154
ASP A  24
LEU A 164
None
1.08A 4e7gA-1t47A:
undetectable
4e7gA-1t47A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g29 NITRATE TRANSPORT
PROTEIN NRTA


(Synechocystis
sp.)
PF13379
(NMT1_2)
4 ALA A 275
VAL A 278
ASP A 279
LEU A 395
None
0.93A 4e7gA-2g29A:
0.3
4e7gA-2g29A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnl GLUTATHIONE
S-TRANSFERASE 1


(Onchocerca
volvulus)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 ALA A 177
VAL A 181
ASP A 178
LEU A 161
None
0.93A 4e7gA-2hnlA:
undetectable
4e7gA-2hnlA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4c BICARBONATE
TRANSPORTER


(Synechocystis
sp. PCC 6803)
PF13379
(NMT1_2)
4 ALA A 277
VAL A 280
ASP A 281
LEU A 404
None
0.94A 4e7gA-2i4cA:
undetectable
4e7gA-2i4cA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE


(Saccharomyces
cerevisiae)
PF00156
(Pribosyltran)
4 ALA A 180
VAL A 155
ASP A 158
LEU A 119
None
1.36A 4e7gA-2jkyA:
undetectable
4e7gA-2jkyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa)
PF00063
(Myosin_head)
4 ALA A  91
VAL A  90
ASP A  61
LEU A  68
None
1.00A 4e7gA-2v26A:
undetectable
4e7gA-2v26A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN


(Escherichia
coli)
PF06751
(EutB)
4 ALA A 344
VAL A 327
ASP A 348
LEU A 383
None
1.33A 4e7gA-3anyA:
undetectable
4e7gA-3anyA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE


(Thermoanaerobacterium
thermosulfurigenes)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
4 ALA A 488
VAL A 489
ASP A 458
LEU A 394
None
1.27A 4e7gA-3bmwA:
undetectable
4e7gA-3bmwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dd6 RIBONUCLEASE PH

(Bacillus
anthracis)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
4 ALA A 184
VAL A 186
ASP A 187
LEU A 218
None
1.43A 4e7gA-3dd6A:
undetectable
4e7gA-3dd6A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvd SERINE
ACETYLTRANSFERASE


(Yersinia pestis)
PF00132
(Hexapep)
PF06426
(SATase_N)
4 ALA A  94
VAL A  95
ASP A  92
LEU A 105
CYS  A 276 (-3.5A)
None
CYS  A 276 (-2.7A)
None
0.93A 4e7gA-3gvdA:
undetectable
4e7gA-3gvdA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxk GOOSE-TYPE LYSOZYME
1


(Gadus morhua)
PF01464
(SLT)
4 ALA A  64
VAL A  65
ASP A  62
LEU A 144
None
1.32A 4e7gA-3gxkA:
undetectable
4e7gA-3gxkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibh SACCHAROMYCES
CEREVISIAE GTT2


(Saccharomyces
cerevisiae)
PF00043
(GST_C)
PF13417
(GST_N_3)
4 ALA A 184
VAL A 188
ASP A 185
LEU A 170
None
0.86A 4e7gA-3ibhA:
undetectable
4e7gA-3ibhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icx PRE MRNA SPLICING
PROTEIN


(Sulfolobus
solfataricus)
PF01798
(Nop)
4 ALA A 348
VAL A 265
ASP A 352
LEU A 278
None
1.46A 4e7gA-3icxA:
undetectable
4e7gA-3icxA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE


(Pimelobacter
simplex)
PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2)
4 ALA A 500
VAL A 493
ASP A 491
LEU A 623
None
1.31A 4e7gA-3k30A:
undetectable
4e7gA-3k30A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muu STRUCTURAL
POLYPROTEIN


(Sindbis virus)
PF00943
(Alpha_E2_glycop)
PF01589
(Alpha_E1_glycop)
4 ALA A  38
VAL A 154
ASP A  40
LEU A 102
None
1.41A 4e7gA-3muuA:
undetectable
4e7gA-3muuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc2 SUGAR
3-KETOREDUCTASE


(Actinomadura
kijaniata)
PF01408
(GFO_IDH_MocA)
4 ALA A 316
VAL A 319
ASP A 320
LEU A 181
None
1.12A 4e7gA-3rc2A:
1.4
4e7gA-3rc2A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sim PROTEIN, FAMILY 18
CHITINASE


(Crocus vernus)
PF00704
(Glyco_hydro_18)
4 ALA A 255
VAL A  15
ASP A 256
LEU A  61
None
1.17A 4e7gA-3simA:
0.7
4e7gA-3simA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sum CERATO-PLATANIN-LIKE
PROTEIN


(Moniliophthora
perniciosa)
PF07249
(Cerato-platanin)
4 ALA A  72
VAL A  98
ASP A  99
LEU A  61
None
1.23A 4e7gA-3sumA:
undetectable
4e7gA-3sumA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tat TYROSINE
AMINOTRANSFERASE


(Escherichia
coli)
PF00155
(Aminotran_1_2)
4 ALA A 367
VAL A 370
ASP A 371
LEU A  20
None
0.80A 4e7gA-3tatA:
undetectable
4e7gA-3tatA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tot GLUTATHIONE
S-TRANSFERASE
PROTEIN


(Ralstonia
solanacearum)
PF13410
(GST_C_2)
PF13417
(GST_N_3)
4 ALA A 158
VAL A 162
ASP A 159
LEU A 144
None
0.96A 4e7gA-3totA:
undetectable
4e7gA-3totA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wi3 DNA REPLICATION
REGULATOR SLD3


(Saccharomyces
cerevisiae)
PF08639
(SLD3)
4 ALA A 260
VAL A 264
ASP A 261
LEU A 357
EDO  A 515 ( 3.3A)
EDO  A 514 ( 3.2A)
None
None
1.19A 4e7gA-3wi3A:
undetectable
4e7gA-3wi3A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyh LYSOZYME G

(Struthio
camelus)
PF01464
(SLT)
4 ALA A  64
VAL A  65
ASP A  62
LEU A 140
None
1.25A 4e7gA-3wyhA:
undetectable
4e7gA-3wyhA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN


(Aequorea
victoria;
Sus scrofa)
PF00063
(Myosin_head)
PF01353
(GFP)
4 ALA A  91
VAL A  90
ASP A  61
LEU A  68
None
1.03A 4e7gA-4anjA:
undetectable
4e7gA-4anjA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cca SYNTAXIN-BINDING
PROTEIN 2


(Homo sapiens)
PF00995
(Sec1)
4 ALA A 397
VAL A 398
ASP A 395
LEU A 364
None
1.32A 4e7gA-4ccaA:
2.7
4e7gA-4ccaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgt CYCLODEXTRIN
GLYCOSYLTRANSFERASE


(Bacillus
circulans)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C)
4 ALA A 487
VAL A 488
ASP A 458
LEU A 394
None
1.26A 4e7gA-4cgtA:
undetectable
4e7gA-4cgtA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwe UNCHARACTERIZED
PROTEIN


(Bacteroides
ovatus)
PF15421
(Polysacc_deac_3)
4 ALA A 234
VAL A 233
ASP A 168
LEU A 217
None
1.28A 4e7gA-4dweA:
undetectable
4e7gA-4dweA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN


(Methylobacillus
flagellatus)
PF13410
(GST_C_2)
PF13417
(GST_N_3)
4 ALA A 155
VAL A 159
ASP A 156
LEU A 141
None
0.75A 4e7gA-4gltA:
undetectable
4e7gA-4gltA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7o SERINE
ACETYLTRANSFERASE


(Vibrio cholerae)
PF00132
(Hexapep)
PF06426
(SATase_N)
4 ALA A  94
VAL A  95
ASP A  92
LEU A 105
CYS  A 303 ( 3.7A)
None
CYS  A 303 (-2.9A)
None
0.92A 4e7gA-4h7oA:
undetectable
4e7gA-4h7oA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4het HYPOTHETICAL
GLYCOSIDE HYDROLASE


(Bacteroides
thetaiotaomicron)
PF13201
(PCMD)
4 ALA A  59
VAL A  55
ASP A  38
LEU A  66
None
1.15A 4e7gA-4hetA:
undetectable
4e7gA-4hetA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9w PROLINE RACEMASE
FAMILY PROTEIN


(Pseudomonas
protegens)
PF05544
(Pro_racemase)
4 ALA A 294
VAL A   6
ASP A   8
LEU A  59
None
1.44A 4e7gA-4j9wA:
undetectable
4e7gA-4j9wA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrl PUTATIVE GLYCOSIDE
HYDROLASE


(Bacteroides
ovatus)
PF13201
(PCMD)
4 ALA A  59
VAL A  55
ASP A  38
LEU A  66
GOL  A 407 (-3.2A)
GOL  A 407 ( 4.9A)
GOL  A 407 (-4.0A)
None
1.17A 4e7gA-4jrlA:
undetectable
4e7gA-4jrlA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN


(Ralstonia
solanacearum)
PF13410
(GST_C_2)
PF13417
(GST_N_3)
4 ALA A 185
VAL A 189
ASP A 186
LEU A 165
None
1.11A 4e7gA-4kf9A:
undetectable
4e7gA-4kf9A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8e GLUTATHIONE
S-TRANSFERASE ENZYME
WITH
THIOREDOXIN-LIKE
DOMAIN


(Xenorhabdus
nematophila)
PF00043
(GST_C)
PF02798
(GST_N)
4 ALA A 167
VAL A 171
ASP A 168
LEU A 153
None
0.94A 4e7gA-4l8eA:
undetectable
4e7gA-4l8eA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me2 UNCHARACTERIZED
PROTEIN


(Brachypodium
distachyon)
no annotation 4 ALA A 136
VAL A 139
ASP A 140
LEU A 178
None
0.98A 4e7gA-4me2A:
undetectable
4e7gA-4me2A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk3 GLUTATHIONE
S-TRANSFERASE


(Cupriavidus
metallidurans)
PF13410
(GST_C_2)
PF13417
(GST_N_3)
4 ALA A 156
VAL A 160
ASP A 157
LEU A 142
None
0.97A 4e7gA-4mk3A:
undetectable
4e7gA-4mk3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oer NIKA PROTEIN

(Brucella suis)
PF00496
(SBP_bac_5)
4 ALA A 262
VAL A 263
ASP A 260
LEU A 338
None
1.23A 4e7gA-4oerA:
undetectable
4e7gA-4oerA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
4 ALA A 496
VAL A 498
ASP A 494
LEU A 504
None
0.97A 4e7gA-4okdA:
undetectable
4e7gA-4okdA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4poo PUTATIVE RNA
METHYLASE


(Bacillus
subtilis)
PF06962
(rRNA_methylase)
4 ALA A  50
VAL A  48
ASP A  26
LEU A  65
None
None
SAM  A 301 ( 4.6A)
None
1.40A 4e7gA-4pooA:
4.2
4e7gA-4pooA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II


(Yersinia pestis)
PF00557
(Peptidase_M24)
PF05195
(AMP_N)
4 ALA A 135
VAL A 139
ASP A 136
LEU A 160
None
None
None
EDO  A 505 (-4.9A)
1.20A 4e7gA-4pv4A:
undetectable
4e7gA-4pv4A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN


(Nitratireductor
pacificus)
PF12838
(Fer4_7)
PF13486
(Dehalogenase)
4 ALA A 438
VAL A 435
ASP A  49
LEU A 359
None
1.18A 4e7gA-4rasA:
undetectable
4e7gA-4rasA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3l E3 UBIQUITIN-PROTEIN
LIGASE RNF38


(Homo sapiens)
PF13639
(zf-RING_2)
4 ALA C 437
VAL C 440
ASP C 441
LEU C 429
None
1.05A 4e7gA-4v3lC:
undetectable
4e7gA-4v3lC:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxg GLUTATHIONE
S-TRANSFERASE


(Plasmodium
falciparum)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 ALA A 161
VAL A 165
ASP A 162
LEU A 139
None
0.87A 4e7gA-4zxgA:
undetectable
4e7gA-4zxgA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE


(Vesicular
stomatitis
virus)
PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap)
4 ALA A 578
VAL A 579
ASP A 574
LEU A 710
None
1.34A 4e7gA-5a22A:
undetectable
4e7gA-5a22A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhm IMMUNOREACTIVE 32
KDA ANTIGEN


(Porphyromonas
gingivalis)
no annotation 4 ALA C 123
VAL C 124
ASP C 121
LEU C 157
None
1.47A 4e7gA-5dhmC:
undetectable
4e7gA-5dhmC:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqs ELONGATION FACTOR
1-GAMMA


(Homo sapiens)
PF00043
(GST_C)
PF02798
(GST_N)
4 ALA A 160
VAL A 164
ASP A 161
LEU A 146
None
1.03A 4e7gA-5dqsA:
undetectable
4e7gA-5dqsA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai PEPTIDOGLYCAN
HYDROLASE GP4


(Salmonella
virus P22)
PF11650
(P22_Tail-4)
4 ALA K  97
VAL K  28
ASP K  31
LEU K  18
None
1.22A 4e7gA-5gaiK:
undetectable
4e7gA-5gaiK:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7w VENOM
5'-NUCLEOTIDASE


(Naja atra)
no annotation 4 ALA A 319
VAL A 320
ASP A 317
LEU A 108
None
1.04A 4e7gA-5h7wA:
undetectable
4e7gA-5h7wA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1


(Homo sapiens;
Escherichia
virus T4)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
4 ALA A1074
VAL A1071
ASP A1070
LEU A1007
None
1.14A 4e7gA-5tzyA:
undetectable
4e7gA-5tzyA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyp DNA POLYMERASE III
SUBUNIT BETA


(Caulobacter
vibrioides)
no annotation 4 ALA A  13
VAL A  17
ASP A  55
LEU A 212
None
1.47A 4e7gA-5wypA:
undetectable
4e7gA-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2v L-METHIONINE
GAMMA-LYASE


(Pseudomonas
putida)
PF01053
(Cys_Met_Meta_PP)
4 ALA A 393
VAL A 390
ASP A 389
LEU A 376
None
1.11A 4e7gA-5x2vA:
undetectable
4e7gA-5x2vA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE


(Legionella
pneumophila)
no annotation 4 ALA A 345
VAL A 314
ASP A 312
LEU A 369
None
1.13A 4e7gA-6bs7A:
1.0
4e7gA-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4f GLUTATHIONE
TRANSFERASE


(Trametes
versicolor)
no annotation 4 ALA A 161
VAL A 165
ASP A 162
LEU A 147
None
0.97A 4e7gA-6f4fA:
undetectable
4e7gA-6f4fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f71 GLUTATHIONE
TRANSFERASE


(Trametes
versicolor)
no annotation 4 ALA A 164
VAL A 168
ASP A 165
LEU A 149
None
0.95A 4e7gA-6f71A:
undetectable
4e7gA-6f71A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)


(Propionibacterium
freudenreichii)
PF01642
(MM_CoA_mutase)
4 ALA B 454
VAL B 623
ASP B 622
LEU B 500
None
1.32A 4e7gA-6reqB:
1.3
4e7gA-6reqB:
22.59