SIMILAR PATTERNS OF AMINO ACIDS FOR 4E7C_D_ACTD504_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		3 GLY A 551
SER A 550
TRP A 346
 None
 0.91A 4e7cD-1cjyA:
0.0		 4e7cD-1cjyA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cn3 COAT PROTEIN VP1

(Polyomavirus
sp.) 		PF00718
(Polyoma_coat) 		3 GLY A 246
SER A 160
TRP A 288
 None
 0.90A 4e7cD-1cn3A:
0.0		 4e7cD-1cn3A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq9 FIBROBLAST GROWTH
FACTOR RECEPTOR 1

(Homo sapiens) 		PF07679
(I-set) 		3 GLY C 182
SER C 181
TRP C 213
 None
 0.79A 4e7cD-1fq9C:
undetectable		 4e7cD-1fq9C:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5s PENICILLIN G ACYLASE
BETA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		3 GLY B 439
SER B 435
TRP B 431
 None
 0.95A 4e7cD-1k5sB:
0.0		 4e7cD-1k5sB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kmd VACUOLAR
MORPHOGENESIS
PROTEIN VAM7

(Saccharomyces
cerevisiae) 		PF00787
(PX) 		3 GLY A  57
SER A  58
TRP A 108
 None
 1.00A 4e7cD-1kmdA:
undetectable		 4e7cD-1kmdA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Gallus gallus) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		3 GLY A 378
SER A 377
TRP A 206
 None
 0.54A 4e7cD-1ktcA:
0.0		 4e7cD-1ktcA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwu FIBRINOGEN BETA
CHAIN

(Petromyzon
marinus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 GLY B 339
SER B 340
TRP B 460
 None
 0.92A 4e7cD-1lwuB:
0.0		 4e7cD-1lwuB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Methanoculleus
thermophilus) 		PF00296
(Bac_luciferase) 		3 GLY A 101
SER A  70
TRP A  35
 None
 0.92A 4e7cD-1rhcA:
0.0		 4e7cD-1rhcA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 GLY A 674
SER A 673
TRP A 365
 None
 0.88A 4e7cD-1ry2A:
0.0		 4e7cD-1ry2A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vry GLYCINE RECEPTOR
ALPHA-1 CHAIN

(Homo sapiens) 		PF02932
(Neur_chan_memb) 		3 GLY A  17
SER A  16
TRP A  34
 None
 0.91A 4e7cD-1vryA:
undetectable		 4e7cD-1vryA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4k SKELETAL MUSCLE
LIM-PROTEIN 3

(Homo sapiens) 		PF00412
(LIM) 		3 GLY A  26
SER A  27
TRP A  29
 None
 0.86A 4e7cD-1x4kA:
undetectable		 4e7cD-1x4kA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x99 LECTIN

(Xerocomellus
chrysenteron) 		PF07367
(FB_lectin) 		3 GLY A  55
SER A  54
TRP A  79
 None
 0.88A 4e7cD-1x99A:
0.8		 4e7cD-1x99A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y2x LECTIN

(Agaricus
bisporus) 		PF07367
(FB_lectin) 		3 GLY A  52
SER A  51
TRP A  77
 None
 0.95A 4e7cD-1y2xA:
undetectable		 4e7cD-1y2xA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkl PROLYL ENDOPEPTIDASE

(Myxococcus
xanthus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 GLY A 569
SER A 570
TRP A 574
 None
None
ZAH  A1533 (-3.7A)
 0.61A 4e7cD-2bklA:
undetectable		 4e7cD-2bklA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 GLY A 221
SER A 220
TRP A 654
 CU  A1742 ( 4.5A)
None
None
 0.73A 4e7cD-2c11A:
undetectable		 4e7cD-2c11A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eng ENDOGLUCANASE V

(Humicola
insolens) 		PF02015
(Glyco_hydro_45) 		3 GLY A  79
SER A  80
TRP A  85
 None
 0.98A 4e7cD-2engA:
undetectable		 4e7cD-2engA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1

(Homo sapiens) 		PF00171
(Aldedh) 		3 GLY A 102
SER A 103
TRP A  14
 None
 0.99A 4e7cD-2j6lA:
0.7		 4e7cD-2j6lA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6w PUTATIVE
GLYCOSYLTRANSFERASE
(MANNOSYLTRANSFERASE
) INVOLVED IN
GLYCOSYLATING THE
PBCV-1 MAJOR CAPSID
PROTEIN

(Paramecium
bursaria
Chlorella virus
1) 		PF05637
(Glyco_transf_34) 		3 GLY A  11
SER A  10
TRP A  76
 None
 0.73A 4e7cD-2p6wA:
undetectable		 4e7cD-2p6wA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		3 GLY A 673
SER A 667
TRP A 666
 None
 0.95A 4e7cD-2pggA:
undetectable		 4e7cD-2pggA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME

(Bos taurus) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 GLY A 220
SER A 219
TRP A 653
 None
 0.80A 4e7cD-2pncA:
undetectable		 4e7cD-2pncA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q17 FORMYLGLYCINE
GENERATING ENZYME

(Streptomyces
coelicolor) 		PF03781
(FGE-sulfatase) 		3 GLY A 295
SER A 294
TRP A 115
 None
 0.91A 4e7cD-2q17A:
undetectable		 4e7cD-2q17A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE

(Phaseolus
vulgaris) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		3 GLY A  72
SER A  55
TRP A  46
 None
 0.92A 4e7cD-2qfrA:
undetectable		 4e7cD-2qfrA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdl CHYMASE 2

(Mesocricetus
auratus) 		PF00089
(Trypsin) 		3 GLY A  44
SER A  43
TRP A 141
 None
 0.83A 4e7cD-2rdlA:
undetectable		 4e7cD-2rdlA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		3 GLY A 147
SER A 146
TRP A 204
 None
 0.96A 4e7cD-2w8qA:
undetectable		 4e7cD-2w8qA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		3 GLY A 585
SER A 583
TRP A 576
 None
 0.93A 4e7cD-2x2iA:
undetectable		 4e7cD-2x2iA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x LECTIN-LIKE FOLD
PROTEIN

(Agaricus
bisporus) 		no annotation 3 GLY E 100
SER E  99
TRP E 106
 None
 0.76A 4e7cD-2y9xE:
undetectable		 4e7cD-2y9xE:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bma D-ALANYL-LIPOTEICHOI
C ACID SYNTHETASE

(Streptococcus
pneumoniae) 		PF04914
(DltD) 		3 GLY A  76
SER A  77
TRP A 138
 None
SO4  A   3 (-3.4A)
SO4  A   3 (-4.8A)
 0.97A 4e7cD-3bmaA:
undetectable		 4e7cD-3bmaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqf THIOL-ACTIVATED
CYTOLYSIN

(Bacillus
anthracis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		3 GLY A 445
SER A 444
TRP A 441
 None
 0.61A 4e7cD-3cqfA:
undetectable		 4e7cD-3cqfA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvh 25-D1.16 HEAVY CHAIN
25-D1.16 LIGHT CHAIN

(Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 GLY L  49
SER L  48
TRP H 106
 None
 0.88A 4e7cD-3cvhL:
undetectable		 4e7cD-3cvhL:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doo SHIKIMATE
DEHYDROGENASE

(Staphylococcus
epidermidis) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		3 GLY A 240
SER A 243
TRP A 247
 None
 0.76A 4e7cD-3dooA:
undetectable		 4e7cD-3dooA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA

(Lactococcus
lactis) 		PF00496
(SBP_bac_5) 		3 GLY A  64
SER A  63
TRP A  49
 None
 0.89A 4e7cD-3drkA:
undetectable		 4e7cD-3drkA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		3 GLY A 650
SER A 651
TRP A 653
 None
 0.80A 4e7cD-3e1sA:
undetectable		 4e7cD-3e1sA:
25.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		3 GLY A 212
SER A 211
TRP A 197
 None
 0.76A 4e7cD-3ed4A:
0.3		 4e7cD-3ed4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezl ACETOACETYL-COA
REDUCTASE

(Burkholderia
pseudomallei) 		PF00106
(adh_short) 		3 GLY A 232
SER A 231
TRP A 225
 None
 0.78A 4e7cD-3ezlA:
undetectable		 4e7cD-3ezlA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		3 GLY A 394
SER A 393
TRP A 222
 None
 0.61A 4e7cD-3h55A:
undetectable		 4e7cD-3h55A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5t AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00202
(Aminotran_3) 		3 GLY A 231
SER A 230
TRP A  61
 None
PLP  A 474 ( 4.0A)
None
 0.97A 4e7cD-3i5tA:
undetectable		 4e7cD-3i5tA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igs N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE 2

(Salmonella
enterica) 		PF04131
(NanE) 		3 GLY A 207
SER A 208
TRP A 219
 SO4  A 234 (-3.5A)
16G  A 230 ( 2.3A)
None
 0.96A 4e7cD-3igsA:
undetectable		 4e7cD-3igsA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		3 GLY A 357
SER A 356
TRP A 563
 None
 0.70A 4e7cD-3k30A:
1.3		 4e7cD-3k30A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		3 GLY A 275
SER A 276
TRP A 303
 None
 0.95A 4e7cD-3k40A:
undetectable		 4e7cD-3k40A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmm UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF04326
(AlbA_2)
PF13749
(HATPase_c_4) 		3 GLY A 407
SER A 329
TRP A 324
 None
 0.92A 4e7cD-3lmmA:
2.4		 4e7cD-3lmmA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oet ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Salmonella
enterica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		3 GLY A  56
SER A  55
TRP A  76
 None
 0.92A 4e7cD-3oetA:
undetectable		 4e7cD-3oetA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Salmonella
enterica) 		PF04131
(NanE) 		3 GLY A 207
SER A 208
TRP A 219
 None
PEG  A 231 (-3.2A)
PEG  A 232 (-3.6A)
 0.98A 4e7cD-3q58A:
undetectable		 4e7cD-3q58A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdt BOLETUS EDULIS
LECTIN

(Boletus edulis) 		PF07367
(FB_lectin) 		3 GLY A  52
SER A  51
TRP A  76
 None
 0.86A 4e7cD-3qdtA:
undetectable		 4e7cD-3qdtA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Mycobacteroides
abscessus) 		PF01259
(SAICAR_synt) 		3 GLY A 253
SER A 252
TRP A 246
 GLY  A 253 ( 0.0A)
SER  A 252 ( 0.0A)
TRP  A 246 ( 0.5A)
 0.97A 4e7cD-3r9rA:
undetectable		 4e7cD-3r9rA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		3 GLY A 276
SER A 277
TRP A 304
 None
 0.93A 4e7cD-3rblA:
undetectable		 4e7cD-3rblA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj8 CARBOHYDRATE OXIDASE

(Microdochium
nivale) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 GLY A 139
SER A 138
TRP A 200
 FAD  A 501 (-3.2A)
FAD  A 501 (-3.0A)
None
 0.96A 4e7cD-3rj8A:
undetectable		 4e7cD-3rj8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rs1 C-TYPE LECTIN DOMAIN
FAMILY 2 MEMBER I

(Mus musculus) 		PF00059
(Lectin_C) 		3 GLY A 108
SER A 107
TRP A 200
 None
 0.99A 4e7cD-3rs1A:
undetectable		 4e7cD-3rs1A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzq ACETOACETYL-COA
REDUCTASE

(Cupriavidus
necator) 		PF00106
(adh_short) 		3 GLY A 230
SER A 229
TRP A 223
 None
 0.76A 4e7cD-3vzqA:
undetectable		 4e7cD-3vzqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuy NITRILASE

(Synechocystis
sp. PCC 6803) 		PF00795
(CN_hydrolase) 		3 GLY A 248
SER A 196
TRP A 227
 None
 0.94A 4e7cD-3wuyA:
undetectable		 4e7cD-3wuyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 3 GLY A 191
SER A 190
TRP A   9
 None
 0.78A 4e7cD-3wvrA:
undetectable		 4e7cD-3wvrA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CMR4

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		3 GLY C  24
SER C  23
TRP C  46
 U  I   9 ( 4.6A)
None
None
 0.55A 4e7cD-3x1lC:
undetectable		 4e7cD-3x1lC:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		3 GLY A1124
SER A1123
TRP A1244
 None
 0.73A 4e7cD-4a4zA:
1.0		 4e7cD-4a4zA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dag FUSION GLYCOPROTEIN
F0
NEUTRALIZING
ANTIBODY DS7 HEAVY
CHAIN

(Human
metapneumovirus;
Homo sapiens) 		PF00523
(Fusion_gly)
PF07654
(C1-set)
PF07686
(V-set) 		3 GLY H 104
SER H 103
TRP A 284
 None
 0.79A 4e7cD-4dagH:
undetectable		 4e7cD-4dagH:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn2 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		3 GLY A 152
SER A 156
TRP A 157
 None
None
KCX  A  66 ( 4.2A)
 0.67A 4e7cD-4gn2A:
undetectable		 4e7cD-4gn2A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hln STARCH SYNTHASE I

(Hordeum vulgare) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		3 GLY A 127
SER A 128
TRP A 590
 None
 0.80A 4e7cD-4hlnA:
undetectable		 4e7cD-4hlnA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsc STREPTOLYSIN O

(Streptococcus
pyogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		3 GLY X 243
SER X 241
TRP X 236
 None
 0.91A 4e7cD-4hscX:
undetectable		 4e7cD-4hscX:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsq PUTATIVE FIMBRIAL
SUBUNIT

(Corynebacterium
diphtheriae) 		PF16569
(GramPos_pilinBB) 		3 GLY A 277
SER A 276
TRP A 211
 None
 0.74A 4e7cD-4hsqA:
undetectable		 4e7cD-4hsqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hss PUTATIVE FIMBRIAL
SUBUNIT

(Corynebacterium
diphtheriae) 		no annotation 3 GLY A 277
SER A 276
TRP A 211
 None
 0.80A 4e7cD-4hssA:
undetectable		 4e7cD-4hssA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE

(Microbacterium
oxydans) 		PF01593
(Amino_oxidase) 		3 GLY A 111
SER A 110
TRP A 236
 None
 0.64A 4e7cD-4i59A:
undetectable		 4e7cD-4i59A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Brachyspira
murdochii) 		PF13407
(Peripla_BP_4) 		3 GLY A 270
SER A 289
TRP A 323
 None
 0.95A 4e7cD-4kqcA:
undetectable		 4e7cD-4kqcA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqx KETOL-ACID
REDUCTOISOMERASE

(Slackia exigua) 		PF01450
(IlvC)
PF07991
(IlvN) 		3 GLY A  50
SER A  49
TRP A 180
 None
 0.99A 4e7cD-4kqxA:
undetectable		 4e7cD-4kqxA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnq INTERFERON-ACTIVABLE
PROTEIN 202

(Mus musculus) 		PF02760
(HIN) 		3 GLY A 235
SER A 234
TRP A 201
 None
 0.83A 4e7cD-4lnqA:
undetectable		 4e7cD-4lnqA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN

(Burkholderia
cenocepacia) 		PF03328
(HpcH_HpaI) 		3 GLY A 223
SER A 242
TRP A 247
 None
 0.98A 4e7cD-4mf4A:
undetectable		 4e7cD-4mf4A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlg BETA-XYLOSIDASE

(uncultured
organism) 		PF04616
(Glyco_hydro_43) 		3 GLY A  36
SER A  35
TRP A  33
 None
 0.71A 4e7cD-4mlgA:
undetectable		 4e7cD-4mlgA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtm PUTATIVE TAIL FIBER
PROTEIN

(Acinetobacter
virus AP22) 		no annotation 3 GLY A 183
SER A 182
TRP A 266
 None
GOL  A 301 ( 2.8A)
GOL  A 301 (-3.0A)
 0.93A 4e7cD-4mtmA:
undetectable		 4e7cD-4mtmA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq1 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Legionella
pneumophila) 		PF00701
(DHDPS) 		3 GLY A 185
SER A 184
TRP A 193
 KPI  A 160 ( 3.8A)
None
None
 0.97A 4e7cD-4nq1A:
undetectable		 4e7cD-4nq1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6q HASAP

(Pseudomonas
aeruginosa) 		PF06438
(HasA) 		3 GLY A 143
SER A  24
TRP A  23
 None
 0.86A 4e7cD-4o6qA:
undetectable		 4e7cD-4o6qA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcs ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01120
(Alpha_L_fucos) 		3 GLY A 286
SER A 285
TRP A 227
 SO4  A 502 ( 4.5A)
None
None
 0.84A 4e7cD-4pcsA:
0.6		 4e7cD-4pcsA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2

(Homo sapiens) 		PF02182
(SAD_SRA) 		3 GLY A 456
SER A 457
TRP A 459
 None
 0.76A 4e7cD-4pw5A:
undetectable		 4e7cD-4pw5A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r72 ABC-TYPE FE3+
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Actinobacillus
pleuropneumoniae) 		PF13343
(SBP_bac_6) 		3 GLY A  38
SER A  37
TRP A  56
 None
 0.94A 4e7cD-4r72A:
undetectable		 4e7cD-4r72A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7q SENSOR HISTIDINE
KINASE

(Vibrio cholerae) 		PF11884
(DUF3404) 		3 GLY A 136
SER A 135
TRP A 131
 None
 0.79A 4e7cD-4r7qA:
undetectable		 4e7cD-4r7qA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw7 L-SHAPED TAIL FIBER
PROTEIN

(Escherichia
virus T5) 		no annotation 3 GLY A1171
SER A1172
TRP A1153
 None
 0.97A 4e7cD-4uw7A:
undetectable		 4e7cD-4uw7A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)

(Clostridium
acetobutylicum) 		PF07470
(Glyco_hydro_88) 		3 GLY A 192
SER A 187
TRP A 186
 None
 0.59A 4e7cD-4wu0A:
undetectable		 4e7cD-4wu0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		3 GLY A 361
SER A 360
TRP A 229
 None
 0.69A 4e7cD-4xprA:
undetectable		 4e7cD-4xprA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2q LECTIN

(Athelia rolfsii) 		PF07367
(FB_lectin) 		3 GLY A  51
SER A  50
TRP A  75
 None
 0.88A 4e7cD-4z2qA:
undetectable		 4e7cD-4z2qA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aey PLASMID SEGREGATION
PROTEIN PARM

(Escherichia
coli) 		PF06406
(StbA) 		3 GLY A  90
SER A  89
TRP A  16
 None
 0.65A 4e7cD-5aeyA:
undetectable		 4e7cD-5aeyA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5s ACETIC ACID

(Talaromyces
cellulolyticus) 		PF13472
(Lipase_GDSL_2) 		3 GLY A 180
SER A 133
TRP A 134
 None
 0.93A 4e7cD-5b5sA:
undetectable		 4e7cD-5b5sA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bob TRANSLATION
INITIATION FACTOR 2
(IF-2 GTPASE)

(Streptococcus
suis) 		no annotation 3 GLY A 251
SER A 254
TRP A 258
 None
None
GOL  A 402 (-3.9A)
 0.93A 4e7cD-5bobA:
undetectable		 4e7cD-5bobA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cde PROLINE DIPEPTIDASE

(Xanthomonas
campestris) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 GLY A  94
SER A  95
TRP A  67
 None
 0.58A 4e7cD-5cdeA:
undetectable		 4e7cD-5cdeA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dvj BINDING PROTEIN
COMPONENT OF ABC
SUGAR TRANSPORTER

(Pseudomonas
putida) 		PF01547
(SBP_bac_1) 		3 GLY A  39
SER A  38
TRP A 250
 None
None
GAL  A 501 (-4.0A)
 0.92A 4e7cD-5dvjA:
undetectable		 4e7cD-5dvjA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewu MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF02514
(CobN-Mg_chel) 		3 GLY A1088
SER A1087
TRP A1033
 MG  A1402 (-3.9A)
BEZ  A1401 (-2.5A)
None
 0.92A 4e7cD-5ewuA:
1.6		 4e7cD-5ewuA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 NICASTRIN

(Homo sapiens) 		PF05450
(Nicastrin) 		3 GLY A 446
SER A 445
TRP A 377
 None
 0.94A 4e7cD-5fn4A:
undetectable		 4e7cD-5fn4A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 GLY A 230
SER A 229
TRP A 298
 None
 0.96A 4e7cD-5fp1A:
undetectable		 4e7cD-5fp1A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		3 GLY A 265
SER A 199
TRP A 197
 None
 0.94A 4e7cD-5hctA:
undetectable		 4e7cD-5hctA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy5 TRYPTOPHAN
6-HALOGENASE

(Streptomyces
toxytricini) 		PF04820
(Trp_halogenase) 		3 GLY A 189
SER A 188
TRP A  19
 None
 0.90A 4e7cD-5hy5A:
undetectable		 4e7cD-5hy5A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC

(Mycobacterium
tuberculosis) 		PF01547
(SBP_bac_1) 		3 GLY A 226
SER A 227
TRP A 172
 None
 0.90A 4e7cD-5k2yA:
undetectable		 4e7cD-5k2yA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3w CPUTA1

(Curtobacterium
pusillum) 		PF01063
(Aminotran_4) 		3 GLY A 123
SER A 131
TRP A 133
 None
 1.00A 4e7cD-5k3wA:
undetectable		 4e7cD-5k3wA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		3 GLY B 156
SER B 155
TRP B 172
 None
 0.95A 4e7cD-5m99B:
undetectable		 4e7cD-5m99B:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		3 GLY A 265
SER A 199
TRP A 197
 None
 0.93A 4e7cD-5p60A:
undetectable		 4e7cD-5p60A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE

(Schizosaccharomyces
pombe) 		PF01487
(DHquinase_I)
PF08501
(Shikimate_dh_N) 		3 GLY C1550
SER C1553
TRP C1557
 None
 0.87A 4e7cD-5swvC:
0.9		 4e7cD-5swvC:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thw DEACYLASE

(Burkholderia
multivorans) 		PF01546
(Peptidase_M20) 		3 GLY A 154
SER A 153
TRP A 138
 None
 0.97A 4e7cD-5thwA:
undetectable		 4e7cD-5thwA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twa BCL-X HOMOLOGOUS
PROTEIN, BHP2

(Geodia cydonium) 		PF00452
(Bcl-2) 		3 GLY A 158
SER A 161
TRP A 165
 None
 0.71A 4e7cD-5twaA:
undetectable		 4e7cD-5twaA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM3

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF17207
(MCM_OB) 		3 GLY 3 159
SER 3 160
TRP 3 111
 None
 0.75A 4e7cD-5udb3:
undetectable		 4e7cD-5udb3:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn5 2,2',3-TRIHYDROXY-3'
-METHOXY-5,5'-DICARB
OXYBIPHENYL
META-CLEAVAGE
COMPOUND HYDROLASE

(Sphingobium sp.
SYK-6) 		PF04909
(Amidohydro_2) 		3 GLY A 287
SER A 288
TRP A  51
 None
 0.69A 4e7cD-5vn5A:
0.9		 4e7cD-5vn5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 3 GLY A 968
SER A 970
TRP A 615
 None
 0.81A 4e7cD-5wblA:
undetectable		 4e7cD-5wblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wk0 DAMAGE-INDUCIBLE
PROTEIN DINB

(Staphylococcus
sp. HMSC055H04) 		no annotation 3 GLY A  76
SER A  77
TRP A  43
 None
 0.89A 4e7cD-5wk0A:
undetectable		 4e7cD-5wk0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4j UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 3 GLY A 365
SER A 367
TRP A 344
 None
 1.00A 4e7cD-5x4jA:
undetectable		 4e7cD-5x4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN

(Escherichia
coli) 		no annotation 3 GLY A 332
SER A 330
TRP A 323
 None
 1.00A 4e7cD-5xnuA:
undetectable		 4e7cD-5xnuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsu XYLOGLUCAN
6-XYLOSYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 3 GLY A 342
SER A 341
TRP A 254
 None
 0.86A 4e7cD-6bsuA:
undetectable		 4e7cD-6bsuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd PROTEASOME SUBUNIT
BETA TYPE-6

(Rattus
norvegicus) 		no annotation 3 GLY 1 216
SER 1 215
TRP 1 136
 None
 0.99A 4e7cD-6epd1:
undetectable		 4e7cD-6epd1:
undetectable