SIMILAR PATTERNS OF AMINO ACIDS FOR 4E7C_C_ACTC506_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 ARG A 112
TRP A 107
HIS A  76
GLY A  77
 None
None
None
C8E  A 456 (-3.2A)
 1.16A 4e7cC-1ethA:
0.0		 4e7cC-1ethA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 ARG B 111
TRP B 106
HIS B  75
GLY B  76
 BOG  B 450 (-3.6A)
None
None
MUP  B 901 (-3.0A)
 1.15A 4e7cC-1lpbB:
0.0		 4e7cC-1lpbB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ARG A  33
ILE A  12
TRP A  14
GLY A  31
 None
 1.40A 4e7cC-1ogyA:
0.0		 4e7cC-1ogyA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yif BETA-1,4-XYLOSIDASE

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43) 		4 ARG A 280
ILE A 276
HIS A 270
GLY A 281
 None
 1.45A 4e7cC-1yifA:
0.0		 4e7cC-1yifA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT

(Escherichia
coli) 		PF10369
(ALS_ss_C)
PF13710
(ACT_5) 		4 ARG A   2
ILE A   4
HIS A  81
GLY A  77
 None
 1.41A 4e7cC-2f1fA:
undetectable		 4e7cC-2f1fA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfe CALPAIN-7

(Homo sapiens) 		PF01067
(Calpain_III) 		4 ARG A 759
ILE A 785
HIS A 711
GLY A 705
 None
 1.27A 4e7cC-2qfeA:
undetectable		 4e7cC-2qfeA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x66 PRNB

(Pseudomonas
fluorescens) 		PF08933
(DUF1864) 		4 ARG A 353
ILE A 275
TRP A 237
GLY A 238
 None
 0.98A 4e7cC-2x66A:
undetectable		 4e7cC-2x66A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3c TREPONEMA DENTICOLA
VARIABLE PROTEIN 1

(Treponema
denticola) 		PF03781
(FGE-sulfatase) 		4 ARG A 309
ILE A 271
HIS A  88
GLY A  78
 None
 1.01A 4e7cC-2y3cA:
undetectable		 4e7cC-2y3cA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 315
TRP A 291
HIS A 250
GLY A 249
 None
 1.41A 4e7cC-3g5wA:
undetectable		 4e7cC-3g5wA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggd SAM-DEPENDENT
METHYLTRANSFERASE

(Trichormus
variabilis) 		PF13649
(Methyltransf_25) 		4 ARG A 141
ILE A 136
HIS A 135
GLY A 132
 None
None
SAH  A 248 ( 4.5A)
SAH  A 248 ( 4.8A)
 1.41A 4e7cC-3ggdA:
undetectable		 4e7cC-3ggdA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ARG A  51
ILE A  52
HIS A 115
GLY A 117
 None
 1.28A 4e7cC-3ho8A:
undetectable		 4e7cC-3ho8A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkj AMINE OXIDASE,
FLAVIN-CONTAINING

(Pseudomonas
syringae group
genomosp. 3) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 ARG A 280
TRP A 276
HIS A 232
GLY A  54
 FAD  A 401 (-3.5A)
FAD  A 401 (-3.8A)
FAD  A 401 (-3.9A)
FAD  A 401 (-3.7A)
 1.31A 4e7cC-3kkjA:
undetectable		 4e7cC-3kkjA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Thermoanaerobacter
pseudethanolicus) 		PF00724
(Oxidored_FMN) 		4 ARG A  64
ILE A 141
HIS A 103
GLY A 105
 None
 1.38A 4e7cC-3krzA:
undetectable		 4e7cC-3krzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		4 ARG A 323
ILE A 320
TRP A 317
GLY A 316
 None
 1.38A 4e7cC-3mwtA:
undetectable		 4e7cC-3mwtA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8a UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF13468
(Glyoxalase_3) 		4 ARG A 264
ILE A  32
HIS A  30
GLY A 106
 None
 1.50A 4e7cC-3p8aA:
undetectable		 4e7cC-3p8aA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnu DIHYDROOROTASE

(Campylobacter
jejuni) 		PF04909
(Amidohydro_2) 		4 ARG A 141
ILE A  98
HIS A 131
GLY A 132
 None
None
ZN  A 336 (-3.1A)
None
 1.29A 4e7cC-3pnuA:
undetectable		 4e7cC-3pnuA:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sg1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
anthracis) 		PF00275
(EPSP_synthase) 		4 ARG A  93
ILE A 124
HIS A 127
GLY A 166
 None
 1.32A 4e7cC-3sg1A:
55.7		 4e7cC-3sg1A:
50.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3swd UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		4 ARG A  91
ILE A  94
TRP A  95
GLY A 164
 QPA  A 115 ( 4.1A)
None
None
EPZ  A 501 (-3.2A)
 0.80A 4e7cC-3swdA:
62.3		 4e7cC-3swdA:
93.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3swd UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		4 ILE A  94
TRP A  95
HIS A 125
GLY A 164
 None
None
None
EPZ  A 501 (-3.2A)
 0.36A 4e7cC-3swdA:
62.3		 4e7cC-3swdA:
93.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae) 		PF00275
(EPSP_synthase) 		4 ARG A  93
ILE A  96
TRP A  97
GLY A 166
 QPA  A 117 ( 4.1A)
None
None
EPZ  A 508 (-3.5A)
 0.75A 4e7cC-3sweA:
60.5		 4e7cC-3sweA:
74.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae) 		PF00275
(EPSP_synthase) 		4 ILE A  96
TRP A  97
HIS A 127
GLY A 166
 None
None
EPZ  A 508 (-4.7A)
EPZ  A 508 (-3.5A)
 0.29A 4e7cC-3sweA:
60.5		 4e7cC-3sweA:
74.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5q NUCLEOPROTEIN

(Mopeia Lassa
virus
reassortant 29) 		PF00843
(Arena_nucleocap) 		4 ARG A 323
ILE A 320
TRP A 317
GLY A 316
 U  C   4 ( 2.8A)
None
None
None
 1.44A 4e7cC-3t5qA:
undetectable		 4e7cC-3t5qA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis) 		PF00128
(Alpha-amylase) 		4 ARG A 393
ILE A 450
TRP A 400
GLY A 399
 None
 1.39A 4e7cC-3ucqA:
undetectable		 4e7cC-3ucqA:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		5 ARG A  92
ILE A  95
TRP A  96
HIS A 126
GLY A 165
 GOL  A 503 (-3.9A)
GOL  A 503 (-4.9A)
GOL  A 503 (-4.2A)
GOL  A 503 ( 4.6A)
GOL  A 503 ( 2.9A)
 0.68A 4e7cC-3vcyA:
60.4		 4e7cC-3vcyA:
79.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1

(Rhodopseudomonas
palustris) 		PF01590
(GAF)
PF08446
(PAS_2) 		4 ARG A 261
ILE A 223
HIS A 266
GLY A 264
 None
 1.32A 4e7cC-4e04A:
undetectable		 4e7cC-4e04A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4o HAPTOGLOBIN

(Sus scrofa) 		PF00089
(Trypsin) 		4 ARG C 146
ILE C 158
HIS C 149
GLY C 148
 NAG  C1004 ( 4.5A)
None
None
None
 1.12A 4e7cC-4f4oC:
undetectable		 4e7cC-4f4oC:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mv3 BIOTIN CARBOXYLASE

(Haemophilus
influenzae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ARG A  16
ILE A  17
HIS A  79
GLY A  81
 None
 1.21A 4e7cC-4mv3A:
undetectable		 4e7cC-4mv3A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB

(Escherichia
coli) 		PF07244
(POTRA)
PF13360
(PQQ_2) 		4 ARG A1273
ILE A1227
TRP A1228
GLY A1275
 None
 1.39A 4e7cC-4pk1A:
undetectable		 4e7cC-4pk1A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 ARG A 260
ILE A 222
HIS A 265
GLY A 263
 None
 1.47A 4e7cC-4r6lA:
undetectable		 4e7cC-4r6lA:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r7u UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 ARG A  92
ILE A  95
TRP A  96
HIS A 126
GLY A 165
 None
None
None
UD1  A 503 ( 4.8A)
UD1  A 503 (-3.3A)
 0.57A 4e7cC-4r7uA:
61.0		 4e7cC-4r7uA:
80.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE

(Psychrobacter
sp. B6) 		PF00155
(Aminotran_1_2) 		4 ARG A  63
ILE A  56
HIS A 289
GLY A 290
 None
 1.32A 4e7cC-4rkcA:
undetectable		 4e7cC-4rkcA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Sus scrofa) 		PF00202
(Aminotran_3) 		4 ARG A 408
ILE A 267
HIS A 275
GLY A 407
 None
 1.19A 4e7cC-4y0iA:
undetectable		 4e7cC-4y0iA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez1 PUTATIVE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
HP_0175

(Helicobacter
pylori) 		PF00639
(Rotamase) 		4 ARG A 160
ILE A 252
HIS A 158
GLY A 212
 None
 1.37A 4e7cC-5ez1A:
undetectable		 4e7cC-5ez1A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0q LIPID BINDING
PROTEIN

(Grifola
frondosa) 		no annotation 4 ARG A  90
TRP A 132
HIS A 104
GLY A 116
 None
 1.50A 4e7cC-5h0qA:
undetectable		 4e7cC-5h0qA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		4 ARG A 406
ILE A 584
HIS A 583
GLY A 282
 None
None
ADP  A1101 (-3.9A)
ADP  A1101 (-3.2A)
 1.35A 4e7cC-5irmA:
undetectable		 4e7cC-5irmA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA

(Methylobacillus
flagellatus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ARG A  16
ILE A  17
HIS A  78
GLY A  80
 None
 1.18A 4e7cC-5ks8A:
undetectable		 4e7cC-5ks8A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz SCFV

(Homo sapiens) 		PF07686
(V-set) 		4 ILE G  98
TRP G 172
HIS G 160
GLY G 175
 None
 1.23A 4e7cC-5ujzG:
undetectable		 4e7cC-5ujzG:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze3 LYSYL OXIDASE
HOMOLOG 2

(Homo sapiens) 		no annotation 4 ARG A 441
TRP A 495
HIS A 496
GLY A 439
 None
 1.08A 4e7cC-5ze3A:
undetectable		 4e7cC-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqj BETA-XYLOSIDASE

(Bacillus
pumilus) 		no annotation 4 ARG A 280
ILE A 276
HIS A 270
GLY A 281
 None
None
None
GOL  A 603 (-3.5A)
 1.40A 4e7cC-5zqjA:
undetectable		 4e7cC-5zqjA:
undetectable