SIMILAR PATTERNS OF AMINO ACIDS FOR 4E7C_B_ACTB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg2 CARBOXYPEPTIDASE G2

(Pseudomonas sp.
RS-16) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLU A 200
ARG A 324
THR A 361
ASP A 362
 ZN  A 501 ( 1.9A)
None
None
None
 1.16A 4e7cA-1cg2A:
0.8
4e7cB-1cg2A:
0.8		 4e7cA-1cg2A:
24.95
4e7cB-1cg2A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxj CLASS II CHITINASE

(Canavalia
ensiformis) 		PF00182
(Glyco_hydro_19) 		4 GLU A  57
ARG A 174
THR A 172
ASP A 169
 None
 1.49A 4e7cA-1dxjA:
undetectable
4e7cB-1dxjA:
0.0		 4e7cA-1dxjA:
20.57
4e7cB-1dxjA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j08 GLUTAREDOXIN-LIKE
PROTEIN

(Pyrococcus
horikoshii) 		PF00085
(Thioredoxin)
PF13192
(Thioredoxin_3) 		4 LYS A 126
GLU A 162
THR A 119
ASP A 118
 None
 1.34A 4e7cA-1j08A:
0.0
4e7cB-1j08A:
0.0		 4e7cA-1j08A:
20.76
4e7cB-1j08A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjc PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF01467
(CTP_transf_like) 		4 LYS A  42
ARG A  51
THR A  10
ASP A  12
 None
 0.94A 4e7cA-1qjcA:
0.0
4e7cB-1qjcA:
0.0		 4e7cA-1qjcA:
18.40
4e7cB-1qjcA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 GLU A 250
ARG A 237
THR A 238
ASP A 205
 None
 1.15A 4e7cA-1rrhA:
0.0
4e7cB-1rrhA:
0.0		 4e7cA-1rrhA:
19.21
4e7cB-1rrhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Archaeoglobus
fulgidus) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 LYS A 292
GLU A 289
THR A  81
ASP A  82
 None
 1.33A 4e7cA-1txgA:
0.0
4e7cB-1txgA:
0.0		 4e7cA-1txgA:
23.50
4e7cB-1txgA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE

(Aedes aegypti) 		PF00266
(Aminotran_5) 		4 GLU A 367
ARG A 294
THR A 366
ASP A 370
 None
 1.43A 4e7cA-2hufA:
0.0
4e7cB-2hufA:
0.0		 4e7cA-2hufA:
24.25
4e7cB-2hufA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 GLU A 245
ARG A 232
THR A 233
ASP A 201
 None
 1.33A 4e7cA-2iujA:
0.0
4e7cB-2iujA:
0.0		 4e7cA-2iujA:
20.07
4e7cB-2iujA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 GLU A 256
ARG A 243
THR A 244
ASP A 213
 None
 1.20A 4e7cA-2iukA:
0.0
4e7cB-2iukA:
0.0		 4e7cA-2iukA:
20.44
4e7cB-2iukA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r14 MORPHINONE REDUCTASE

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		4 GLU A 292
ARG A 316
THR A 321
ASP A 319
 None
 1.25A 4e7cA-2r14A:
0.0
4e7cB-2r14A:
0.0		 4e7cA-2r14A:
24.62
4e7cB-2r14A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LYS A 310
GLU A 313
THR A 473
ASP A 475
 None
 1.38A 4e7cA-2ze0A:
undetectable
4e7cB-2ze0A:
undetectable		 4e7cA-2ze0A:
21.35
4e7cB-2ze0A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 GLU A 209
ARG A 271
THR A 246
ASP A 272
 None
 1.42A 4e7cA-3ef1A:
undetectable
4e7cB-3ef1A:
undetectable		 4e7cA-3ef1A:
22.11
4e7cB-3ef1A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gri DIHYDROOROTASE

(Staphylococcus
aureus) 		PF01979
(Amidohydro_1) 		4 GLU A 235
ARG A 280
THR A 233
ASP A 284
 None
 1.14A 4e7cA-3griA:
1.1
4e7cB-3griA:
1.2		 4e7cA-3griA:
23.95
4e7cB-3griA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgn ADC OPERON REPRESSOR
ADCR

(Streptococcus
pneumoniae) 		PF01047
(MarR) 		4 GLU A  82
ARG A 102
THR A  98
ASP A  99
 None
 1.22A 4e7cA-3tgnA:
undetectable
4e7cB-3tgnA:
undetectable		 4e7cA-3tgnA:
14.87
4e7cB-3tgnA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6f UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14730
(DUF4468) 		4 GLU A  43
ARG A 175
THR A 155
ASP A 156
 None
 1.40A 4e7cA-4e6fA:
undetectable
4e7cB-4e6fA:
undetectable		 4e7cA-4e6fA:
18.57
4e7cB-4e6fA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE

(Lactococcus
lactis) 		PF02811
(PHP) 		4 LYS A  75
GLU A  36
THR A 256
ASP A 263
 None
 1.12A 4e7cA-4gk8A:
1.1
4e7cB-4gk8A:
1.1		 4e7cA-4gk8A:
20.58
4e7cB-4gk8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE

(Lactococcus
lactis) 		PF02811
(PHP) 		4 LYS A  77
GLU A  36
THR A 256
ASP A 263
 None
 1.14A 4e7cA-4gk8A:
1.1
4e7cB-4gk8A:
1.1		 4e7cA-4gk8A:
20.58
4e7cB-4gk8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbu SIMILAR TO
N-ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF13420
(Acetyltransf_4) 		4 GLU A 158
ARG A 113
THR A 114
ASP A 160
 None
 1.36A 4e7cA-4mbuA:
undetectable
4e7cB-4mbuA:
undetectable		 4e7cA-4mbuA:
17.10
4e7cB-4mbuA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD

(Pseudomonas
aeruginosa) 		PF04453
(OstA_C) 		4 GLU A 353
ARG A 349
THR A 351
ASP A 338
 None
 1.47A 4e7cA-5ivaA:
undetectable
4e7cB-5ivaA:
undetectable		 4e7cA-5ivaA:
20.74
4e7cB-5ivaA:
20.74