SIMILAR PATTERNS OF AMINO ACIDS FOR 4E7B_C_ACTC513

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ib1 14-3-3 ZETA ISOFORM
SEROTONIN
N-ACETYLTRANSFERASE

(Homo sapiens;
Ovis aries) 		PF00244
(14-3-3)
PF00583
(Acetyltransf_1) 		3 TYR A 211
HIS A 164
ARG E  89
 None
 0.98A 4e7bC-1ib1A:
0.3		 4e7bC-1ib1A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhj APC10

(Homo sapiens) 		PF03256
(ANAPC10) 		3 TYR A  53
HIS A 152
ARG A 154
 None
 0.67A 4e7bC-1jhjA:
undetectable		 4e7bC-1jhjA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jlx AGGLUTININ

(Amaranthus
caudatus) 		PF07468
(Agglutinin) 		3 TYR A  76
HIS A 119
ARG A  70
 A2G  A 305 ( 3.4A)
None
None
 0.74A 4e7bC-1jlxA:
0.0		 4e7bC-1jlxA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		3 TYR A  96
HIS A 242
ARG A 245
 None
 1.17A 4e7bC-1jnfA:
0.1		 4e7bC-1jnfA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpe DSBD-ALPHA

(Escherichia
coli) 		PF11412
(DsbC) 		3 TYR A  40
HIS A  66
ARG A  78
 None
 0.96A 4e7bC-1jpeA:
0.0		 4e7bC-1jpeA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		3 TYR A  30
HIS A 434
ARG A 431
 None
 0.99A 4e7bC-1js6A:
0.0		 4e7bC-1js6A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE

(Homo sapiens) 		PF02574
(S-methyl_trans) 		3 TYR A 305
HIS A 306
ARG A 278
 None
 1.03A 4e7bC-1lt8A:
0.4		 4e7bC-1lt8A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 TYR A 357
HIS A 389
ARG A 354
 None
 1.21A 4e7bC-1qdlA:
0.0		 4e7bC-1qdlA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		3 TYR A  93
HIS A 246
ARG A 249
 None
 1.17A 4e7bC-1qjmA:
1.3		 4e7bC-1qjmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkl COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		3 TYR A 163
HIS A 126
ARG A 246
 None
 1.21A 4e7bC-1tklA:
undetectable		 4e7bC-1tklA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x6m GLUTATHIONE-DEPENDEN
T
FORMALDEHYDE-ACTIVAT
ING ENZYME

(Paracoccus
denitrificans) 		PF04828
(GFA) 		3 TYR A 109
HIS A  99
ARG A 111
 None
 1.06A 4e7bC-1x6mA:
undetectable		 4e7bC-1x6mA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5j T-SNARE AFFECTING A
LATE GOLGI
COMPARTMENT PROTEIN
1

(Saccharomyces
cerevisiae) 		no annotation 3 TYR A  25
HIS A  29
ARG A  28
 None
 1.01A 4e7bC-2c5jA:
undetectable		 4e7bC-2c5jA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddh ACYL-COA OXIDASE

(Rattus
norvegicus) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 TYR A 487
HIS A 532
ARG A 490
 None
 1.21A 4e7bC-2ddhA:
undetectable		 4e7bC-2ddhA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 TYR A 154
HIS A 107
ARG A 175
 None
 0.84A 4e7bC-2e1bA:
undetectable		 4e7bC-2e1bA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 TYR A 294
HIS A 298
ARG A 297
 None
 1.18A 4e7bC-2e5vA:
undetectable		 4e7bC-2e5vA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2

(Homo sapiens) 		PF00378
(ECH_1) 		3 TYR A  69
HIS A  73
ARG A  72
 None
 0.98A 4e7bC-2fw2A:
1.0		 4e7bC-2fw2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j88 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H  52
HIS H  50
ARG H  58
 None
 1.10A 4e7bC-2j88H:
undetectable		 4e7bC-2j88H:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2
G2/MITOTIC-SPECIFIC
CYCLIN-B1

(Homo sapiens;
Homo sapiens) 		PF00069
(Pkinase)
PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		3 TYR B 177
HIS A 121
ARG A 122
 None
 1.13A 4e7bC-2jgzB:
undetectable		 4e7bC-2jgzB:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kjq DNAA-RELATED PROTEIN

(Neisseria
meningitidis) 		no annotation 3 TYR A  29
HIS A  51
ARG A  32
 None
 0.75A 4e7bC-2kjqA:
undetectable		 4e7bC-2kjqA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrk HYPOTHETICAL PROTEIN
GRPB

(Enterococcus
faecalis) 		PF04229
(GrpB) 		3 TYR A  88
HIS A 101
ARG A  86
 None
 1.00A 4e7bC-2nrkA:
undetectable		 4e7bC-2nrkA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE

(Shewanella
oneidensis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 TYR A 387
HIS A 409
ARG A 413
 None
 1.16A 4e7bC-2oasA:
undetectable		 4e7bC-2oasA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		3 TYR A  30
HIS A 358
ARG A 362
 None
 0.81A 4e7bC-2q6zA:
undetectable		 4e7bC-2q6zA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE

(Streptomyces
sp. PGA64) 		PF01494
(FAD_binding_3) 		3 TYR A 377
HIS A 465
ARG A 461
 None
 0.94A 4e7bC-2qa1A:
undetectable		 4e7bC-2qa1A:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp1 PERIPLASMIC
IRON-BINDING PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		3 TYR A  44
HIS A  43
ARG A  42
 FE  A1347 (-4.1A)
FE  A1347 (-3.3A)
None
 0.63A 4e7bC-2vp1A:
undetectable		 4e7bC-2vp1A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		3 TYR A 322
HIS A 297
ARG A 321
 None
 1.20A 4e7bC-2vr5A:
undetectable		 4e7bC-2vr5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		3 TYR A 929
HIS A 869
ARG A 867
 None
 0.90A 4e7bC-2vsqA:
undetectable		 4e7bC-2vsqA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 TYR A 393
HIS A 505
ARG A 377
 None
 1.14A 4e7bC-2wtzA:
undetectable		 4e7bC-2wtzA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 TYR A  22
HIS A  26
ARG A  16
 None
 1.03A 4e7bC-2wyhA:
undetectable		 4e7bC-2wyhA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 TYR A  76
HIS A 206
ARG A 207
 None
 0.98A 4e7bC-2xsjA:
undetectable		 4e7bC-2xsjA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 TYR A 393
HIS A 415
ARG A 419
 None
 1.08A 4e7bC-3d3uA:
undetectable		 4e7bC-3d3uA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		3 TYR X  15
HIS X  14
ARG X  13
 FE  X 326 (-4.3A)
FE  X 326 (-3.4A)
None
 0.68A 4e7bC-3e13X:
undetectable		 4e7bC-3e13X:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9k KYNURENINASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		3 TYR A  86
HIS A 343
ARG A 107
 None
 1.19A 4e7bC-3e9kA:
undetectable		 4e7bC-3e9kA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 TYR A 393
HIS A 415
ARG A 419
 None
 1.03A 4e7bC-3eh7A:
undetectable		 4e7bC-3eh7A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f11 IRON TRANSPORT
PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		3 TYR A  55
HIS A  54
ARG A  53
 FE  A 400 (-4.2A)
SO4  A 402 (-3.3A)
None
 0.85A 4e7bC-3f11A:
undetectable		 4e7bC-3f11A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Yersinia pestis) 		PF00425
(Chorismate_bind) 		3 TYR A 240
HIS A  57
ARG A  58
 None
SO4  A 456 (-4.7A)
SO4  A 456 (-3.9A)
 1.06A 4e7bC-3gseA:
undetectable		 4e7bC-3gseA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnp OXIDOREDUCTASE

(Bacillus cereus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 TYR A 155
HIS A 228
ARG A 157
 None
 0.88A 4e7bC-3hnpA:
3.1		 4e7bC-3hnpA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 TYR A 155
HIS A 228
ARG A 157
 None
 0.92A 4e7bC-3i23A:
3.3		 4e7bC-3i23A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1

(Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S) 		3 TYR 1  31
HIS 1  35
ARG 1  34
 None
 0.81A 4e7bC-3i9v1:
undetectable		 4e7bC-3i9v1:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		3 TYR A 189
HIS A 194
ARG A 192
 SO4  A 447 (-4.7A)
SO4  A 432 ( 4.8A)
SO4  A 432 (-4.4A)
 0.90A 4e7bC-3ie1A:
undetectable		 4e7bC-3ie1A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 TYR A1695
HIS A1511
ARG A1568
 None
 0.93A 4e7bC-3jb9A:
undetectable		 4e7bC-3jb9A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kie CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 TYR A 424
HIS A 426
ARG A 734
 None
 0.95A 4e7bC-3kieA:
undetectable		 4e7bC-3kieA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mck C705 MONOCLONAL
HEAVY CHAIN

(Mus musculus) 		no annotation 3 TYR H  54
HIS H  52
ARG H  60
 None
 1.17A 4e7bC-3mckH:
undetectable		 4e7bC-3mckH:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA

(Archaeoglobus
fulgidus) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 TYR A  73
HIS A 204
ARG A 205
 None
 0.99A 4e7bC-3mm5A:
undetectable		 4e7bC-3mm5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY

(Shewanella
oneidensis) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		3 TYR A  88
HIS A  90
ARG A 152
 None
 1.20A 4e7bC-3on7A:
1.2		 4e7bC-3on7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouu BIOTIN CARBOXYLASE

(Campylobacter
jejuni) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 TYR A 439
HIS A 443
ARG A 442
 None
 1.07A 4e7bC-3ouuA:
undetectable		 4e7bC-3ouuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 TYR A 381
HIS A 385
ARG A 384
 None
 0.94A 4e7bC-3p5pA:
undetectable		 4e7bC-3p5pA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 TYR A 427
HIS A 429
ARG A 736
 None
 1.07A 4e7bC-3ra2A:
undetectable		 4e7bC-3ra2A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8d COENZYME A
TRANSFERASE

(Yersinia pestis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 TYR A 396
HIS A 395
ARG A 362
 None
 1.13A 4e7bC-3s8dA:
undetectable		 4e7bC-3s8dA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 TYR A 425
HIS A 427
ARG A 734
 None
 0.83A 4e7bC-3shmA:
undetectable		 4e7bC-3shmA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue1 PENICILLIN-BINDING
PROTEIN 1A

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		3 TYR A 291
HIS A 295
ARG A 294
 None
 1.20A 4e7bC-3ue1A:
undetectable		 4e7bC-3ue1A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux1 CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 TYR A 426
HIS A 428
ARG A 734
 None
 1.06A 4e7bC-3ux1A:
undetectable		 4e7bC-3ux1A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw5 CELLOBIOSE
2-EPIMERASE

(Ruminococcus
albus) 		PF07221
(GlcNAc_2-epim) 		3 TYR A 373
HIS A 374
ARG A 377
 None
 0.97A 4e7bC-3vw5A:
undetectable		 4e7bC-3vw5A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4r CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		3 TYR A 272
HIS A 230
ARG A 274
 None
 1.22A 4e7bC-3w4rA:
0.5		 4e7bC-3w4rA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkh CELLOBIOSE
2-EPIMERASE

(Rhodothermus
marinus) 		PF07221
(GlcNAc_2-epim) 		3 TYR A 389
HIS A 390
ARG A 393
 None
BMA  A 502 ( 4.0A)
None
 0.95A 4e7bC-3wkhA:
undetectable		 4e7bC-3wkhA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 TYR B1743
HIS B1559
ARG B1616
 None
 1.05A 4e7bC-3zefB:
undetectable		 4e7bC-3zefB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		3 TYR A 379
HIS A 338
ARG A 381
 None
 1.21A 4e7bC-4a5qA:
undetectable		 4e7bC-4a5qA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		3 TYR A 517
HIS A 162
ARG A 137
 None
 1.09A 4e7bC-4aeeA:
undetectable		 4e7bC-4aeeA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akk NITRATE REGULATORY
PROTEIN

(Klebsiella
oxytoca) 		PF03861
(ANTAR)
PF08376
(NIT) 		3 TYR A 107
HIS A 138
ARG A 134
 None
 1.16A 4e7bC-4akkA:
undetectable		 4e7bC-4akkA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		3 TYR A 482
HIS A 438
ARG A 484
 None
 1.17A 4e7bC-4dwsA:
undetectable		 4e7bC-4dwsA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egv ACETYL-COA
ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 3 TYR A 169
HIS A 173
ARG A 172
 None
 0.98A 4e7bC-4egvA:
undetectable		 4e7bC-4egvA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eip PUTATIVE
FAD-MONOOXYGENASE

(Lechevalieria
aerocolonigenes) 		PF01494
(FAD_binding_3) 		3 TYR A 408
HIS A 506
ARG A 502
 None
 0.88A 4e7bC-4eipA:
undetectable		 4e7bC-4eipA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exq UROPORPHYRINOGEN
DECARBOXYLASE

(Burkholderia
thailandensis) 		PF01208
(URO-D) 		3 TYR A  21
HIS A 352
ARG A 356
 NA  A 401 ( 4.8A)
None
None
 0.77A 4e7bC-4exqA:
0.2		 4e7bC-4exqA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fi4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Caulobacter sp.
K31) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TYR A 160
HIS A 213
ARG A 148
 GOL  A 502 ( 4.6A)
GOL  A 502 (-4.4A)
None
 1.14A 4e7bC-4fi4A:
undetectable		 4e7bC-4fi4A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF02811
(PHP) 		3 TYR A 279
HIS A 258
ARG A 248
 None
 1.15A 4e7bC-4gx8A:
undetectable		 4e7bC-4gx8A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6n AMINODEOXYCHORISMATE
LYASE

(Saccharomyces
cerevisiae) 		PF01063
(Aminotran_4) 		3 TYR A 258
HIS A 257
ARG A 255
 PLP  A 500 (-3.6A)
None
PLP  A 500 (-3.0A)
 1.05A 4e7bC-4k6nA:
undetectable		 4e7bC-4k6nA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kca ENDO-1,5-ALPHA-L-ARA
BINANASE

(Bos taurus) 		PF00085
(Thioredoxin)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		3 TYR A 405
HIS A 559
ARG A 560
 None
None
IOD  A 706 (-4.6A)
 1.19A 4e7bC-4kcaA:
undetectable		 4e7bC-4kcaA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR E 196
HIS E 234
ARG E 195
 None
 1.09A 4e7bC-4md8E:
undetectable		 4e7bC-4md8E:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mru SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 TYR A 302
HIS A 386
ARG A 298
 None
 1.21A 4e7bC-4mruA:
undetectable		 4e7bC-4mruA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o26 TELOMERASE REVERSE
TRANSCRIPTASE

(Oryzias latipes) 		PF12009
(Telomerase_RBD) 		3 TYR A 543
HIS A 422
ARG A 541
 None
 1.09A 4e7bC-4o26A:
undetectable		 4e7bC-4o26A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oon PENICILLIN-BINDING
PROTEIN 1A

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		3 TYR A 310
HIS A 314
ARG A 313
 None
 1.00A 4e7bC-4oonA:
undetectable		 4e7bC-4oonA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpl E3 UBIQUITIN-PROTEIN
LIGASE RNF146

(Mus musculus) 		PF02825
(WWE)
PF13920
(zf-C3HC4_3) 		3 TYR A 154
HIS A 159
ARG A 162
 None
 0.80A 4e7bC-4qplA:
undetectable		 4e7bC-4qplA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qri HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Leptospira
interrogans) 		PF00156
(Pribosyltran) 		3 TYR A 111
HIS A 115
ARG A 114
 None
 1.12A 4e7bC-4qriA:
undetectable		 4e7bC-4qriA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rso CAPSID PROTEIN VP1

(Non-human
primate
Adeno-associated
virus) 		PF00740
(Parvo_coat) 		3 TYR A 426
HIS A 428
ARG A 734
 None
 1.04A 4e7bC-4rsoA:
undetectable		 4e7bC-4rsoA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		3 TYR A 361
HIS A 383
ARG A 382
 None
 0.99A 4e7bC-4ufsA:
undetectable		 4e7bC-4ufsA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis) 		PF01494
(FAD_binding_3) 		3 TYR A 377
HIS A 462
ARG A 458
 None
 1.02A 4e7bC-4x4jA:
undetectable		 4e7bC-4x4jA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4l CELLOBIOSE
2-EPIMERASE

(Caldicellulosiruptor
saccharolyticus) 		PF07221
(GlcNAc_2-epim) 		3 TYR A 376
HIS A 377
ARG A 380
 None
 0.96A 4e7bC-4z4lA:
undetectable		 4e7bC-4z4lA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxs VIRION EGRESS
PROTEIN UL31

(Human
alphaherpesvirus
1) 		PF02718
(Herpes_UL31) 		3 TYR B 228
HIS B 227
ARG B 229
 None
 1.13A 4e7bC-4zxsB:
undetectable		 4e7bC-4zxsB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7o PROLIFERATING CELL
NUCLEAR ANTIGEN

(Leishmania
donovani) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 TYR A 279
HIS A  49
ARG A 281
 None
 0.87A 4e7bC-5b7oA:
undetectable		 4e7bC-5b7oA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN

(Leishmania
donovani) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 TYR A 246
HIS A  49
ARG A 248
 None
 0.88A 4e7bC-5cfkA:
undetectable		 4e7bC-5cfkA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00144
(Beta-lactamase) 		3 TYR B 149
HIS B 111
ARG B 147
 None
 1.17A 4e7bC-5eviB:
undetectable		 4e7bC-5eviB:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		3 TYR A 295
HIS A 299
ARG A 298
 None
 1.11A 4e7bC-5gslA:
undetectable		 4e7bC-5gslA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		3 TYR A 426
HIS A 470
ARG A 466
 None
 0.80A 4e7bC-5h2vA:
undetectable		 4e7bC-5h2vA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		3 TYR B 340
HIS B 336
ARG B 360
 None
 0.86A 4e7bC-5hb4B:
undetectable		 4e7bC-5hb4B:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htv PUTATIVE XYLULOSE
KINASE

(Arabidopsis
thaliana) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 TYR A 420
HIS A 415
ARG A 245
 None
 1.08A 4e7bC-5htvA:
undetectable		 4e7bC-5htvA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		3 TYR A  96
HIS A 152
ARG A  19
 None
VDM  A 502 (-4.7A)
None
 1.22A 4e7bC-5hvoA:
1.1		 4e7bC-5hvoA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		3 TYR A 129
HIS A 133
ARG A 132
 None
 0.96A 4e7bC-5isoA:
undetectable		 4e7bC-5isoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixd TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 3 TYR A  41
HIS A 106
ARG A 108
 None
 1.21A 4e7bC-5ixdA:
undetectable		 4e7bC-5ixdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqk PEPTIDASE, PUTATIVE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		3 TYR A 717
HIS A 606
ARG A 584
 None
 1.17A 4e7bC-5jqkA:
undetectable		 4e7bC-5jqkA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbp GLYCOSYL HYDROLASE,
FAMILY 38

(Enterococcus
faecalis) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 TYR A  22
HIS A  26
ARG A  16
 None
 1.03A 4e7bC-5kbpA:
undetectable		 4e7bC-5kbpA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 3 TYR B  34
HIS B  38
ARG B  37
 None
 1.13A 4e7bC-5khnB:
undetectable		 4e7bC-5khnB:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkc CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN (JO),CELL
WALL SURFACE ANCHOR
FAMILY PROTEIN (IN)

(Streptococcus
pneumoniae) 		no annotation 3 TYR A 145
HIS A 172
ARG A 719
 None
 1.04A 4e7bC-5mkcA:
undetectable		 4e7bC-5mkcA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 196
HIS A 234
ARG A 195
 None
 1.07A 4e7bC-5movA:
undetectable		 4e7bC-5movA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tge PHAGE TERMINASE
LARGE SUBUNIT

(Thermus virus
P74-26) 		PF17289
(Terminase_6C) 		3 TYR A 301
HIS A 427
ARG A 319
 None
 1.20A 4e7bC-5tgeA:
undetectable		 4e7bC-5tgeA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2g PENICILLIN-BINDING
PROTEIN 1A

(Haemophilus
influenzae) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		3 TYR A 311
HIS A 315
ARG A 314
 None
 1.08A 4e7bC-5u2gA:
undetectable		 4e7bC-5u2gA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 3 TYR A1320
HIS A1272
ARG A1271
 None
 1.12A 4e7bC-5wblA:
undetectable		 4e7bC-5wblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wos CNPV058 BCL-2 LIKE
PROTEIN

(Canarypox virus) 		no annotation 3 TYR A  78
HIS A  82
ARG A 127
 None
 0.91A 4e7bC-5wosA:
undetectable		 4e7bC-5wosA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y81 ACTIN-RELATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		no annotation 3 TYR F 286
HIS F 248
ARG F 285
 None
 1.04A 4e7bC-5y81F:
undetectable		 4e7bC-5y81F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9r HYDROXYETHYLPHOSPHON
ATE DIOXYGENASE

(Streptomyces
albus) 		no annotation 3 TYR A 362
HIS A 341
ARG A 428
 None
 1.13A 4e7bC-6b9rA:
undetectable		 4e7bC-6b9rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae) 		no annotation 3 TYR A 379
HIS A 451
ARG A 447
 None
 1.02A 4e7bC-6brdA:
undetectable		 4e7bC-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Homo sapiens) 		no annotation 3 TYR B 191
HIS B 151
ARG B 221
 None
 1.19A 4e7bC-6d6uB:
undetectable		 4e7bC-6d6uB:
22.33