SIMILAR PATTERNS OF AMINO ACIDS FOR 4E3A_B_ADNB500_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtx AMINOTRANSFERASE

(Neisseria
meningitidis) 		PF00155
(Aminotran_1_2) 		4 SER A 124
SER A 205
TYR A 132
PRO A 155
 None
 1.35A 4e3aB-3jtxA:
2.9		 4e3aB-3jtxA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxf ENDOGLUCANASE

(Escherichia
coli) 		PF01270
(Glyco_hydro_8) 		4 SER A 115
SER A  58
TYR A 182
PRO A  94
 None
 1.27A 4e3aB-3qxfA:
0.0		 4e3aB-3qxfA:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		4 SER A  60
SER A 115
TYR A 158
PRO A 314
 ADN  A 353 (-4.6A)
ADN  A 353 ( 4.0A)
ADN  A 353 (-3.6A)
ADN  A 353 (-4.2A)
 0.17A 4e3aB-3uboA:
56.6		 4e3aB-3uboA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjn NUCLEOCAPSID

(Mammalian
rubulavirus 5) 		PF00973
(Paramyxo_ncap) 		4 SER A 169
SER A  49
TYR A 209
PRO A  80
 None
 1.31A 4e3aB-4xjnA:
0.0		 4e3aB-4xjnA:
23.64