SIMILAR PATTERNS OF AMINO ACIDS FOR 4E3A_A_ADNA500_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ri6 | PUTATIVE ISOMERASEYBHE (Escherichiacoli) |
PF10282(Lactonase) | 4 | SER A 302TYR A 304GLY A 295PRO A 325 | None | 1.41A | 4e3aA-1ri6A:undetectable | 4e3aA-1ri6A:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v7v | CHITOBIOSEPHOSPHORYLASE (Vibrioproteolyticus) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 4 | SER A 49TYR A 52GLY A 345PRO A 389 | None | 1.34A | 4e3aA-1v7vA:undetectable | 4e3aA-1v7vA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wyt | GLYCINEDEHYDROGENASE(DECARBOXYLATING)SUBUNIT 1GLYCINEDEHYDROGENASESUBUNIT 2(P-PROTEIN) (Thermusthermophilus) |
PF02347(GDC-P) | 4 | SER B 319TYR A 163GLY A 265PRO B 95 | None | 1.31A | 4e3aA-1wytB:1.2 | 4e3aA-1wytB:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xf1 | C5A PEPTIDASE (Streptococcuspyogenes) |
PF00082(Peptidase_S8)PF02225(PA)PF06280(fn3_5)PF13585(CHU_C) | 4 | SER A 284TYR A 281GLY A 286PRO A 538 | None | 1.47A | 4e3aA-1xf1A:3.0 | 4e3aA-1xf1A:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zfj | INOSINEMONOPHOSPHATEDEHYDROGENASE (Streptococcuspyogenes) |
PF00478(IMPDH)PF00571(CBS) | 4 | SER A 308TYR A 390GLY A 344PRO A 306 | IMP A 500 (-2.6A)IMP A 500 (-4.5A)IMP A 500 ( 3.7A)None | 1.46A | 4e3aA-1zfjA:1.8 | 4e3aA-1zfjA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zfj | INOSINEMONOPHOSPHATEDEHYDROGENASE (Streptococcuspyogenes) |
PF00478(IMPDH)PF00571(CBS) | 4 | SER A 308TYR A 390GLY A 345PRO A 306 | IMP A 500 (-2.6A)IMP A 500 (-4.5A)IMP A 500 (-4.0A)None | 1.28A | 4e3aA-1zfjA:1.8 | 4e3aA-1zfjA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b4w | HYPOTHETICALPROTEIN, CONSERVED (Leishmaniamajor) |
PF08950(DUF1861) | 4 | SER A 281TYR A 250GLY A 268PRO A 36 | None | 1.08A | 4e3aA-2b4wA:undetectable | 4e3aA-2b4wA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b71 | CYCLOPHILIN-LIKEPROTEIN (Plasmodiumyoelii) |
PF00160(Pro_isomerase) | 4 | SER A 136TYR A 108GLY A 100PRO A 94 | None | 1.49A | 4e3aA-2b71A:undetectable | 4e3aA-2b71A:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cu0 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Pyrococcushorikoshii) |
PF00478(IMPDH)PF00571(CBS) | 4 | SER A 299TYR A 381GLY A 335PRO A 297 | XMP A1001 (-2.7A)XMP A1001 (-4.5A)XMP A1001 (-3.4A)None | 1.48A | 4e3aA-2cu0A:1.8 | 4e3aA-2cu0A:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cu0 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Pyrococcushorikoshii) |
PF00478(IMPDH)PF00571(CBS) | 4 | SER A 299TYR A 381GLY A 336PRO A 297 | XMP A1001 (-2.7A)XMP A1001 (-4.5A)XMP A1001 (-3.6A)None | 1.31A | 4e3aA-2cu0A:1.8 | 4e3aA-2cu0A:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jyf | 2',3'-CYCLICNUCLEOTIDE2'-PHOSPHODIESTERASE/3'-NUCLEOTIDASEBIFUNCTIONALPERIPLASMIC PROTEIN (Klebsiellapneumoniae) |
PF00149(Metallophos) | 4 | SER A 230TYR A 227GLY A 267PRO A 269 | None | 1.44A | 4e3aA-3jyfA:1.9 | 4e3aA-3jyfA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kzv | UNCHARACTERIZEDOXIDOREDUCTASEYIR035C (Saccharomycescerevisiae) |
PF00106(adh_short) | 4 | SER A 243TYR A 241GLY A 179PRO A 221 | None | 1.27A | 4e3aA-3kzvA:6.6 | 4e3aA-3kzvA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nx4 | PUTATIVEOXIDOREDUCTASE (Salmonellaenterica) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | SER A 117TYR A 291GLY A 115PRO A 113 | None | 1.48A | 4e3aA-3nx4A:3.2 | 4e3aA-3nx4A:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pnu | DIHYDROOROTASE (Campylobacterjejuni) |
PF04909(Amidohydro_2) | 4 | SER A 107TYR A 113GLY A 105PRO A 95 | None | 1.18A | 4e3aA-3pnuA:undetectable | 4e3aA-3pnuA:26.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsd | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH)PF00571(CBS) | 4 | SER A 306TYR A 388GLY A 342PRO A 304 | XMP A 500 (-2.7A)XMP A 500 (-4.8A)XMP A 500 (-3.3A)None | 1.43A | 4e3aA-3tsdA:2.9 | 4e3aA-3tsdA:23.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsd | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH)PF00571(CBS) | 4 | SER A 306TYR A 388GLY A 343PRO A 304 | XMP A 500 (-2.7A)XMP A 500 (-4.8A)XMP A 500 (-3.8A)None | 1.29A | 4e3aA-3tsdA:2.9 | 4e3aA-3tsdA:23.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ubo | ADENOSINE KINASE (Sinorhizobiummeliloti) |
PF00294(PfkB) | 4 | SER A 60TYR A 158GLY A 275PRO A 314 | ADN A 353 (-4.6A)ADN A 353 (-3.6A)ADN A 353 (-3.7A)ADN A 353 (-4.2A) | 0.20A | 4e3aA-3uboA:57.0 | 4e3aA-3uboA:71.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vi3 | INTEGRIN ALPHA-5 (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 4 | SER A 229TYR A 261GLY A 190PRO A 183 | NoneNAG A2009 (-4.7A)NoneNone | 1.12A | 4e3aA-3vi3A:undetectable | 4e3aA-3vi3A:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4egv | ACETYL-COAACETYLTRANSFERASE (Mycolicibacteriumsmegmatis) |
no annotation | 4 | SER A 484TYR A 451GLY A 486PRO A 488 | None | 1.30A | 4e3aA-4egvA:undetectable | 4e3aA-4egvA:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fxs | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Vibrio cholerae) |
PF00478(IMPDH)PF00571(CBS) | 4 | SER A 305TYR A 387GLY A 341PRO A 303 | IMP A 701 (-2.6A)IMP A 701 (-4.6A)IMP A 701 (-3.5A)None | 1.50A | 4e3aA-4fxsA:undetectable | 4e3aA-4fxsA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fxs | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Vibrio cholerae) |
PF00478(IMPDH)PF00571(CBS) | 4 | SER A 305TYR A 387GLY A 342PRO A 303 | IMP A 701 (-2.6A)IMP A 701 (-4.6A)IMP A 701 (-3.5A)None | 1.34A | 4e3aA-4fxsA:undetectable | 4e3aA-4fxsA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mc0 | PUTATIVESESQUITERPENECYCLASE (Kitasatosporasetae) |
no annotation | 4 | SER A 178TYR A 153GLY A 180PRO A 182 | None | 1.40A | 4e3aA-4mc0A:undetectable | 4e3aA-4mc0A:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o9x | TCDB2, TCCC3 (Photorhabdusluminescens) |
PF03534(SpvB)PF12255(TcdB_toxin_midC)PF12256(TcdB_toxin_midN) | 4 | SER A 325TYR A 327GLY A 673PRO A 654 | None | 1.46A | 4e3aA-4o9xA:undetectable | 4e3aA-4o9xA:10.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wk4 | INTEGRIN ALPHA-5 (Homo sapiens) |
PF01839(FG-GAP) | 4 | SER A 229TYR A 261GLY A 190PRO A 183 | NoneNAG A 505 (-4.2A)NoneNone | 0.99A | 4e3aA-4wk4A:undetectable | 4e3aA-4wk4A:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zzq | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Dictyosteliumdiscoideum) |
PF00840(Glyco_hydro_7) | 4 | SER A 348TYR A 251GLY A 259PRO A 228 | None | 1.48A | 4e3aA-4zzqA:undetectable | 4e3aA-4zzqA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lvc | VP1 (Aichivirus A) |
no annotation | 4 | SER a 165TYR a 163GLY a 194PRO a 125 | None | 1.48A | 4e3aA-5lvca:undetectable | 4e3aA-5lvca:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ou3 | INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE,INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE (Mycolicibacteriumthermoresistibile) |
no annotation | 4 | SER A 199TYR A 281GLY A 235PRO A 197 | IMP A 400 (-2.6A)IMP A 400 (-4.6A)IMP A 400 (-3.5A)None | 1.47A | 4e3aA-5ou3A:1.9 | 4e3aA-5ou3A:13.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ou3 | INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE,INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE (Mycolicibacteriumthermoresistibile) |
no annotation | 4 | SER A 199TYR A 281GLY A 236PRO A 197 | IMP A 400 (-2.6A)IMP A 400 (-4.6A)IMP A 400 (-3.6A)None | 1.31A | 4e3aA-5ou3A:1.9 | 4e3aA-5ou3A:13.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tgf | UNCHARACTERIZEDPROTEIN (Bacteroidesdorei) |
PF00144(Beta-lactamase) | 4 | SER A 322TYR A 26GLY A 288PRO A 287 | None | 1.28A | 4e3aA-5tgfA:undetectable | 4e3aA-5tgfA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tw1 | DNA-DIRECTED RNAPOLYMERASE SUBUNITBETA (Mycolicibacteriumsmegmatis) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF10385(RNA_pol_Rpb2_45) | 4 | SER C1036TYR C1094GLY C1038PRO C1047 | None | 1.48A | 4e3aA-5tw1C:undetectable | 4e3aA-5tw1C:15.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5upy | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Listeriamonocytogenes) |
PF00478(IMPDH) | 4 | SER A 306TYR A 388GLY A 342PRO A 304 | IMP A 500 (-2.6A)IMP A 500 (-4.6A)IMP A 500 ( 3.7A)None | 1.46A | 4e3aA-5upyA:undetectable | 4e3aA-5upyA:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5upy | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Listeriamonocytogenes) |
PF00478(IMPDH) | 4 | SER A 306TYR A 388GLY A 343PRO A 304 | IMP A 500 (-2.6A)IMP A 500 (-4.6A)IMP A 500 (-3.6A)None | 1.30A | 4e3aA-5upyA:undetectable | 4e3aA-5upyA:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uuw | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH) | 4 | SER A 306TYR A 388GLY A 342PRO A 304 | IMP A 501 (-2.8A)IMP A 501 (-4.7A)IMP A 501 (-3.1A)None | 1.48A | 4e3aA-5uuwA:undetectable | 4e3aA-5uuwA:27.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uuw | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH) | 4 | SER A 306TYR A 388GLY A 343PRO A 304 | IMP A 501 (-2.8A)IMP A 501 (-4.7A)IMP A 501 (-3.9A)None | 1.33A | 4e3aA-5uuwA:undetectable | 4e3aA-5uuwA:27.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uze | INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE,INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE (Clostridiumperfringens) |
PF00478(IMPDH) | 4 | SER A 301TYR A 383GLY A 337PRO A 299 | IMP A 500 (-2.5A)IMP A 500 (-4.8A)IMP A 500 (-3.4A)None | 1.46A | 4e3aA-5uzeA:3.0 | 4e3aA-5uzeA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uze | INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE,INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE (Clostridiumperfringens) |
PF00478(IMPDH) | 4 | SER A 301TYR A 383GLY A 338PRO A 299 | IMP A 500 (-2.5A)IMP A 500 (-4.8A)IMP A 500 (-3.4A)None | 1.31A | 4e3aA-5uzeA:3.0 | 4e3aA-5uzeA:22.96 |