SIMILAR PATTERNS OF AMINO ACIDS FOR 4E1G_B_LNLB701

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 ARG A 644
GLY A 641
ALA A 642
SER A 166
GLY A 180
 FLC  A 756 (-4.3A)
None
FLC  A 756 (-3.0A)
FLC  A 756 (-2.6A)
None
 0.91A 4e1gB-1b0kA:
0.0		 4e1gB-1b0kA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 PHE A 222
TYR A 428
GLY A 205
ALA A 206
LEU A 213
 None
 0.96A 4e1gB-1b41A:
0.0		 4e1gB-1b41A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b88 T CELL RECEPTOR
V-ALPHA DOMAIN

(Mus musculus) 		PF07686
(V-set) 		5 PHE A  66
ILE A  50
PHE A  33
TYR A  25
ALA A  94
 None
 1.04A 4e1gB-1b88A:
undetectable		 4e1gB-1b88A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1blk P55 BLK PROTEIN
TYROSINE KINASE

(Mus musculus) 		PF00017
(SH2) 		5 GLY A  48
ALA A  49
SER A  71
GLY A  76
LEU A  72
 None
 1.09A 4e1gB-1blkA:
0.0		 4e1gB-1blkA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxn PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN)
PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN)

(Cupriavidus
necator) 		PF00016
(RuBisCO_large)
PF00101
(RuBisCO_small)
PF02788
(RuBisCO_large_N) 		5 TYR I 123
ILE A 409
GLY A 189
GLY A 195
LEU A 196
 None
 0.95A 4e1gB-1bxnI:
2.3		 4e1gB-1bxnI:
11.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 ARG A 120
PHE A 205
PHE A 209
TYR A 355
ILE A 377
PHE A 381
TYR A 385
GLY A 526
ALA A 527
GLY A 533
LEU A 534
 SCL  A 700 (-3.9A)
OAS  A 530 ( 4.7A)
None
SCL  A 700 (-4.3A)
None
OAS  A 530 ( 4.7A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 ( 4.0A)
OAS  A 530 ( 3.3A)
 0.41A 4e1gB-1ebvA:
58.5		 4e1gB-1ebvA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 PHE A 210
TYR A 355
ILE A 377
PHE A 381
GLY A 526
ALA A 527
 HEM  A 601 (-4.7A)
SCL  A 700 (-4.3A)
None
OAS  A 530 ( 4.7A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 1.32A 4e1gB-1ebvA:
58.5		 4e1gB-1ebvA:
62.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 PHE A 329
ILE A 427
PHE A 428
ALA A 348
GLY A 262
 None
 1.08A 4e1gB-1hr7A:
0.0		 4e1gB-1hr7A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd3 CHORISMATE LYASE

(Escherichia
coli) 		PF04345
(Chor_lyase) 		5 TYR A 164
GLY A 136
ALA A 135
GLY A 132
LEU A  11
 None
 0.96A 4e1gB-1jd3A:
undetectable		 4e1gB-1jd3A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1p TRIGGER FACTOR

(Escherichia
coli) 		PF00254
(FKBP_C) 		5 PHE A  42
PHE A  55
ILE A  52
PHE A  74
GLY A  49
 None
 1.11A 4e1gB-1l1pA:
undetectable		 4e1gB-1l1pA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE

(Thermotoga
maritima) 		PF04961
(FTCD_C) 		5 GLY A  25
ALA A  26
SER A  29
GLY A  32
LEU A  73
 None
 1.00A 4e1gB-1o5hA:
undetectable		 4e1gB-1o5hA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		5 PHE A 242
TYR A 447
GLY A 219
ALA A 220
LEU A 227
 None
 0.92A 4e1gB-1thgA:
undetectable		 4e1gB-1thgA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis) 		PF02595
(Gly_kinase) 		5 ILE A 141
GLY A 244
ALA A 243
GLY A 250
LEU A 251
 None
SO4  A 373 (-3.5A)
SO4  A 373 ( 4.2A)
None
None
 1.06A 4e1gB-1to6A:
undetectable		 4e1gB-1to6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3h T-CELL RECEPTOR
ALPHA-CHAIN

(Mus musculus) 		PF07686
(V-set) 		5 PHE A  66
ILE A  49
PHE A  32
TYR A  24
ALA A  98
 None
 0.98A 4e1gB-1u3hA:
undetectable		 4e1gB-1u3hA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		5 TYR A 278
ILE A  15
PHE A  12
GLY A 221
GLY A 214
 None
 1.10A 4e1gB-1u7gA:
undetectable		 4e1gB-1u7gA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		5 PHE A 231
TYR A 422
GLY A 212
ALA A 213
LEU A 220
 None
 0.89A 4e1gB-1ukcA:
undetectable		 4e1gB-1ukcA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE

(Cavia porcellus) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 TYR A 181
GLY A 152
ALA A 153
SER A 156
GLY A 159
 None
NAP  A1350 (-3.3A)
NAP  A1350 (-3.4A)
None
None
 0.87A 4e1gB-1v3tA:
undetectable		 4e1gB-1v3tA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vra ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ

(Bacillus
halodurans) 		PF01960
(ArgJ) 		5 PHE A 111
ILE A  29
GLY A 150
ALA A 151
GLY A  41
 None
EDO  A 210 (-3.8A)
EDO  A 204 ( 3.8A)
None
None
 1.05A 4e1gB-1vraA:
undetectable		 4e1gB-1vraA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1

(Bacteroides
thetaiotaomicron) 		no annotation 5 PHE A 218
TYR A 229
SER A 118
GLY A 115
LEU A 114
 None
 1.02A 4e1gB-1zxoA:
undetectable		 4e1gB-1zxoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ash QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Thermotoga
maritima) 		PF01702
(TGT) 		5 ILE A 209
PHE A 240
GLY A 243
SER A 213
GLY A 211
 None
None
None
None
EDO  A 404 (-3.0A)
 0.99A 4e1gB-2ashA:
undetectable		 4e1gB-2ashA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avt DNA POLYMERASE III
BETA SUBUNIT

(Streptococcus
pyogenes) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 PHE A  82
PHE A  11
ILE A   6
PHE A   4
LEU A 106
 None
 1.03A 4e1gB-2avtA:
undetectable		 4e1gB-2avtA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 PHE A  82
PHE A  11
ILE A   6
PHE A   4
LEU A 106
 None
 1.04A 4e1gB-2awaA:
undetectable		 4e1gB-2awaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT

(Homo sapiens) 		PF00676
(E1_dh) 		5 TYR A  86
ILE A 188
GLY A 117
ALA A 116
GLY A 111
 None
 0.87A 4e1gB-2bfeA:
undetectable		 4e1gB-2bfeA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A   5
GLY A  34
SER A   7
GLY A  11
LEU A  12
 FAD  A1002 (-4.5A)
FAD  A1002 ( 4.0A)
FAD  A1002 (-3.0A)
None
None
 1.06A 4e1gB-2e5vA:
undetectable		 4e1gB-2e5vA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk9 PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE II,
GAMMA

(Homo sapiens) 		PF01504
(PIP5K) 		5 TYR A 189
GLY A  54
ALA A  56
SER A  58
LEU A  62
 None
 1.02A 4e1gB-2gk9A:
undetectable		 4e1gB-2gk9A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Staphylococcus
aureus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 TYR A 300
GLY A 347
SER A 397
GLY A 399
LEU A 398
 None
 1.09A 4e1gB-2gqdA:
undetectable		 4e1gB-2gqdA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoe N-ACETYLGLUCOSAMINE
KINASE

(Thermotoga
maritima) 		PF00480
(ROK) 		5 ARG A 288
ILE A 206
SER A 291
GLY A 293
LEU A 295
 None
 0.86A 4e1gB-2hoeA:
undetectable		 4e1gB-2hoeA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		5 GLY A 307
ALA A 308
SER A 311
GLY A 314
LEU A 315
 UDP  A1401 ( 3.9A)
UDP  A1401 (-4.3A)
None
None
None
 0.49A 4e1gB-2iyfA:
undetectable		 4e1gB-2iyfA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		5 PHE A 213
TYR A 392
GLY A 196
ALA A 197
LEU A 204
 PHE  A 213 ( 1.3A)
TYR  A 392 ( 1.3A)
GLY  A 196 ( 0.0A)
ALA  A 197 ( 0.0A)
LEU  A 204 ( 0.6A)
 0.98A 4e1gB-2ogsA:
undetectable		 4e1gB-2ogsA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD

(Aquifex
aeolicus) 		PF00005
(ABC_tran) 		5 ILE A  23
GLY A  37
ALA A  38
SER A  41
GLY A 215
 None
None
None
SO4  A 226 ( 2.8A)
None
 1.07A 4e1gB-2pclA:
2.3		 4e1gB-2pclA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv7 T-PROTEIN [INCLUDES:
CHORISMATE MUTASE
(EC 5.4.99.5) (CM)
AND PREPHENATE
DEHYDROGENASE (EC
1.3.1.12) (PDH)]

(Haemophilus
influenzae) 		PF02153
(PDH) 		5 ARG A 121
PHE A 203
ILE A 207
GLY A 114
ALA A 117
 None
 1.11A 4e1gB-2pv7A:
undetectable		 4e1gB-2pv7A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN

(Bacteroides
fragilis) 		PF00210
(Ferritin) 		5 PHE A  55
GLY A  45
ALA A  46
SER A 103
LEU A 107
 None
 1.08A 4e1gB-2vzbA:
undetectable		 4e1gB-2vzbA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		5 ILE A 321
TYR A 106
GLY A 248
ALA A 247
SER A 246
 None
 1.10A 4e1gB-2yiaA:
2.1		 4e1gB-2yiaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae) 		PF00202
(Aminotran_3) 		5 ILE A 403
GLY A  50
ALA A  51
GLY A  55
LEU A  54
 None
 1.03A 4e1gB-2zukA:
undetectable		 4e1gB-2zukA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 ILE A 388
TYR A  24
GLY A 255
ALA A 256
LEU A 379
 None
 1.09A 4e1gB-3abbA:
1.9		 4e1gB-3abbA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuo UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YGAV

(Escherichia
coli) 		PF01022
(HTH_5) 		5 GLY A  42
ALA A  41
SER A  40
GLY A  38
LEU A  78
 None
 1.02A 4e1gB-3cuoA:
undetectable		 4e1gB-3cuoA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh9 THIOREDOXIN
REDUCTASE 1

(Drosophila
melanogaster) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PHE A 181
PHE A 205
GLY A 204
ALA A 203
LEU A 282
 None
 1.01A 4e1gB-3dh9A:
2.1		 4e1gB-3dh9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9x MUTT/NUDIX FAMILY
PROTEIN

(Listeria
innocua) 		PF00293
(NUDIX) 		5 ILE A  49
GLY A 136
ALA A 135
GLY A 143
LEU A 144
 None
 0.96A 4e1gB-3i9xA:
undetectable		 4e1gB-3i9xA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom) 		5 ILE A1636
GLY A1588
ALA A1589
SER A1592
LEU A1596
 None
 1.01A 4e1gB-3jbzA:
2.1		 4e1gB-3jbzA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3md2 MATRIX PROTEIN 1

(Influenza A
virus) 		PF00598
(Flu_M1) 		5 GLY A 122
ALA A 123
SER A 126
GLY A 129
LEU A 130
 None
 0.78A 4e1gB-3md2A:
undetectable		 4e1gB-3md2A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pea ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00378
(ECH_1) 		6 ILE A 102
GLY A  62
ALA A  25
SER A  60
GLY A  54
LEU A  18
 None
 1.25A 4e1gB-3peaA:
undetectable		 4e1gB-3peaA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 TYR A 196
ILE A  53
GLY A 127
ALA A 128
LEU A 189
 GOL  A 522 ( 4.8A)
None
None
None
None
 1.05A 4e1gB-3pfeA:
undetectable		 4e1gB-3pfeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qh4 ESTERASE LIPW

(Mycobacterium
marinum) 		PF07859
(Abhydrolase_3) 		5 PHE A 210
ILE A  23
PHE A  25
ALA A 123
GLY A  90
 None
 1.09A 4e1gB-3qh4A:
undetectable		 4e1gB-3qh4A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00701
(DHDPS) 		5 ILE A 205
PHE A 226
GLY A 225
ALA A 224
SER A 223
 None
 1.07A 4e1gB-3s5nA:
undetectable		 4e1gB-3s5nA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3x OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 PHE A  29
ILE A  39
PHE A  67
ALA A  72
LEU A  47
 None
 0.90A 4e1gB-3u3xA:
undetectable		 4e1gB-3u3xA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfj 2-DEHYDROPANTOATE
2-REDUCTASE

(Enterococcus
faecium) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 GLY A   9
ALA A  10
SER A  13
GLY A  16
LEU A  17
 NAD  A 401 (-3.0A)
NAD  A 401 (-3.1A)
None
None
None
 0.92A 4e1gB-3wfjA:
undetectable		 4e1gB-3wfjA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 PHE A 191
ALA A 241
SER A 245
GLY A 247
LEU A 246
 None
 0.99A 4e1gB-4b6lA:
undetectable		 4e1gB-4b6lA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB

(Bacillus
subtilis) 		PF01471
(PG_binding_1)
PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		5 ILE A 263
PHE A 222
GLY A 254
ALA A 308
SER A 311
 None
 0.95A 4e1gB-4c2fA:
undetectable		 4e1gB-4c2fA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis) 		PF00521
(DNA_topoisoIV) 		5 ARG A 238
ILE A 224
GLY A 331
SER A 240
GLY A 229
 None
 0.88A 4e1gB-4ddqA:
0.4		 4e1gB-4ddqA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE
PROTEIN DBF4 HOMOLOG
A

(Homo sapiens) 		PF00069
(Pkinase)
PF07535
(zf-DBF) 		5 PHE A 414
PHE B 253
GLY A 432
ALA A 455
LEU A 461
 None
 0.92A 4e1gB-4f99A:
undetectable		 4e1gB-4f99A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		5 PHE A 670
PHE A 741
ILE A 468
GLY A 677
LEU A 709
 None
 1.06A 4e1gB-4hsuA:
2.1		 4e1gB-4hsuA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Influenza A
virus;
Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		5 GLY A 405
ALA A 406
SER A 409
GLY A 412
LEU A 413
 None
 0.76A 4e1gB-4iq4A:
undetectable		 4e1gB-4iq4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2f GLUTATHIONE
S-TRANSFERASE

(Ricinus
communis) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ARG A 216
GLY A 173
ALA A 172
GLY A 166
LEU A 165
 None
 0.88A 4e1gB-4j2fA:
undetectable		 4e1gB-4j2fA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 TYR A 298
GLY A 345
SER A 395
GLY A 397
LEU A 396
 None
None
K  A 501 ( 4.8A)
None
None
 1.05A 4e1gB-4ls5A:
undetectable		 4e1gB-4ls5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT

(Rhodopseudomonas
palustris) 		PF03480
(DctP) 		5 PHE A 118
GLY A  99
ALA A 109
GLY A 133
LEU A 132
 None
 0.99A 4e1gB-4oanA:
undetectable		 4e1gB-4oanA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN

(Anaplasma
phagocytophilum) 		PF01596
(Methyltransf_3) 		5 GLY A  68
ALA A  71
SER A  70
GLY A  45
LEU A  48
 None
None
SAM  A 301 (-2.9A)
None
None
 0.90A 4e1gB-4pclA:
undetectable		 4e1gB-4pclA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pds SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ARG A 297
ILE A 325
GLY A 296
SER A 300
LEU A 304
 None
 0.90A 4e1gB-4pdsA:
undetectable		 4e1gB-4pdsA:
20.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 ARG A 121
PHE A 206
PHE A 210
TYR A 356
ILE A 378
PHE A 382
TYR A 386
GLY A 527
ALA A 528
SER A 531
GLY A 534
LEU A 535
 BOG  A 604 ( 3.7A)
None
EDO  A 616 (-3.5A)
IBP  A 601 (-4.5A)
None
None
IBP  A 601 (-4.8A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
EDO  A 616 (-3.0A)
EDO  A 616 ( 4.4A)
 0.16A 4e1gB-4ph9A:
64.9		 4e1gB-4ph9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		8 ARG A 121
PHE A 211
TYR A 356
ILE A 378
PHE A 382
GLY A 527
ALA A 528
SER A 531
 BOG  A 604 ( 3.7A)
HEM  A 602 (-4.6A)
IBP  A 601 (-4.5A)
None
None
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
 1.37A 4e1gB-4ph9A:
64.9		 4e1gB-4ph9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		5 TYR A 624
PHE A 313
GLY A 305
ALA A 326
LEU A 334
 None
 1.06A 4e1gB-4qjyA:
undetectable		 4e1gB-4qjyA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		5 PHE A 219
TYR A 421
GLY A 202
ALA A 203
LEU A 210
 None
 0.98A 4e1gB-4qwwA:
undetectable		 4e1gB-4qwwA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN

(Lactococcus
phage 1358) 		no annotation 5 ARG A  29
ILE A  92
GLY A  31
GLY A  59
LEU A  22
 None
 1.10A 4e1gB-4rggA:
undetectable		 4e1gB-4rggA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ARG A 486
ILE A  59
GLY A  78
GLY A 130
LEU A 131
 None
 0.99A 4e1gB-4rvwA:
undetectable		 4e1gB-4rvwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqv ALGM1
ALGM2

(Sphingomonas
sp.) 		PF00528
(BPD_transp_1) 		5 PHE A 199
PHE A 142
TYR B 163
ALA B 199
LEU B 204
 None
 1.02A 4e1gB-4tqvA:
undetectable		 4e1gB-4tqvA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		5 GLY A 254
ALA A 255
SER A 258
GLY A 261
LEU A 262
 None
 0.90A 4e1gB-4us4A:
0.5		 4e1gB-4us4A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs SIMILARITY TO
HELICASE MOT1

(Encephalitozoon
cuniculi) 		no annotation 5 TYR C 554
ILE C 603
PHE C 606
ALA C 574
GLY C 568
 None
 0.93A 4e1gB-4wzsC:
undetectable		 4e1gB-4wzsC:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 PHE A 509
TYR A 506
GLY A 570
ALA A 569
GLY A 565
 None
 1.06A 4e1gB-4ye5A:
undetectable		 4e1gB-4ye5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aog CATIONIC PEROXIDASE
SPC4

(Sorghum bicolor) 		PF00141
(peroxidase) 		5 PHE A  80
ILE A 197
ALA A 171
GLY A 179
LEU A 180
 HEM  A1341 (-3.4A)
None
None
None
GOL  A1344 ( 4.3A)
 1.05A 4e1gB-5aogA:
1.4		 4e1gB-5aogA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2g ENDOLYSIN,CLAUDIN-4

(Escherichia
virus T4;
Homo sapiens) 		PF00822
(PMP22_Claudin)
PF00959
(Phage_lysozyme) 		5 GLY A1330
ALA A1332
SER A1334
GLY A1292
LEU A1338
 None
 1.10A 4e1gB-5b2gA:
undetectable		 4e1gB-5b2gA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cad SM80.1 VICILIN

(Solanum
melongena) 		PF00190
(Cupin_1) 		5 PHE A 162
ILE A 169
PHE A 173
TYR A 150
GLY A 142
 None
 1.05A 4e1gB-5cadA:
undetectable		 4e1gB-5cadA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdn DNA GYRASE SUBUNIT A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV) 		5 ARG A 238
ILE A 224
GLY A 332
SER A 240
GLY A 229
 ARG  A 238 ( 0.6A)
ILE  A 224 ( 0.7A)
GLY  A 332 ( 0.0A)
SER  A 240 ( 0.0A)
GLY  A 229 ( 0.0A)
 1.07A 4e1gB-5cdnA:
undetectable		 4e1gB-5cdnA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 ARG A 226
PHE A 551
PHE A 249
PHE A 538
GLY A 540
 None
 0.97A 4e1gB-5clwA:
undetectable		 4e1gB-5clwA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqe MATRIX PROTEIN 1

(Influenza A
virus) 		PF00598
(Flu_M1) 		5 GLY A 122
ALA A 123
SER A 126
GLY A 129
LEU A 130
 None
 0.82A 4e1gB-5cqeA:
undetectable		 4e1gB-5cqeA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d04 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Neisseria
meningitidis) 		PF00793
(DAHP_synth_1) 		5 ARG C 175
GLY C 203
ALA C 204
SER C 206
GLY C 227
 CL  C 402 (-2.9A)
None
None
None
None
 1.07A 4e1gB-5d04C:
undetectable		 4e1gB-5d04C:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtp PROBABLE ENOYL-COA
HYDRATASE ECHA6

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 ILE A  93
GLY A  59
ALA A  23
GLY A  51
LEU A  15
 None
 1.09A 4e1gB-5dtpA:
undetectable		 4e1gB-5dtpA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		5 ILE A1636
GLY A1588
ALA A1589
SER A1592
LEU A1596
 None
 0.91A 4e1gB-5h64A:
undetectable		 4e1gB-5h64A:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i45 GLYCOSYL
TRANSFERASES GROUP 1
FAMILY PROTEIN

(Francisella
tularensis) 		PF00534
(Glycos_transf_1) 		5 ILE A 170
GLY A 280
ALA A 279
SER A 255
GLY A 179
 None
 1.08A 4e1gB-5i45A:
undetectable		 4e1gB-5i45A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikb GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
4,GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
4

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 PHE A  49
ILE A 234
GLY A 219
ALA A  85
LEU A  40
 None
 1.05A 4e1gB-5ikbA:
undetectable		 4e1gB-5ikbA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 ARG A 120
PHE A 205
PHE A 209
TYR A 355
ILE A 377
PHE A 381
TYR A 385
ALA A 527
SER A 530
GLY A 533
 ID8  A 601 ( 4.4A)
None
None
ID8  A 601 (-3.8A)
None
None
ID8  A 601 ( 3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
None
 0.57A 4e1gB-5ikrA:
62.5		 4e1gB-5ikrA:
87.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 ARG A 120
PHE A 205
PHE A 209
TYR A 355
ILE A 377
PHE A 381
TYR A 385
GLY A 526
ALA A 527
GLY A 533
LEU A 534
 ID8  A 601 ( 4.4A)
None
None
ID8  A 601 (-3.8A)
None
None
ID8  A 601 ( 3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
None
None
 0.25A 4e1gB-5ikrA:
62.5		 4e1gB-5ikrA:
87.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 ARG A 120
PHE A 210
TYR A 355
ILE A 377
PHE A 381
GLY A 526
ALA A 527
 ID8  A 601 ( 4.4A)
COH  A 602 (-4.0A)
ID8  A 601 (-3.8A)
None
None
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 1.41A 4e1gB-5ikrA:
62.5		 4e1gB-5ikrA:
87.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw1 T-CELL RECEPTOR
ALPHA CHAIN

(Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		5 PHE A  67
ILE A  51
PHE A  34
TYR A  26
ALA A  95
 None
 1.05A 4e1gB-5iw1A:
undetectable		 4e1gB-5iw1A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 PHE A 445
ILE A 751
GLY A 736
ALA A 482
LEU A 436
 None
 0.98A 4e1gB-5kufA:
undetectable		 4e1gB-5kufA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		no annotation 5 ILE A  27
GLY A  41
ALA A  42
SER A  45
GLY A 219
 None
 1.08A 4e1gB-5lj9A:
2.4		 4e1gB-5lj9A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq4 CYAGOX

(Cyanothece sp.
PCC 7425) 		PF00881
(Nitroreductase) 		5 PHE A 164
PHE A 188
GLY A 151
ALA A 152
LEU A 173
 None
 1.05A 4e1gB-5lq4A:
undetectable		 4e1gB-5lq4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oon UNDECAPRENYL-DIPHOSP
HATASE

(Escherichia
coli) 		no annotation 5 GLY A 176
ALA A 177
SER A 180
GLY A 182
LEU A 184
 None
 0.94A 4e1gB-5oonA:
undetectable		 4e1gB-5oonA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		PF04095
(NAPRTase) 		5 TYR A  36
ILE A 206
SER A 155
GLY A  61
LEU A  62
 None
 1.10A 4e1gB-5u2nA:
undetectable		 4e1gB-5u2nA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4n FRUCTOSE-1

(Neisseria
gonorrhoeae) 		PF01116
(F_bP_aldolase) 		5 PHE A 203
GLY A 155
ALA A 154
SER A 197
GLY A 233
 None
None
None
None
PO4  A 401 ( 3.2A)
 0.99A 4e1gB-5u4nA:
0.8		 4e1gB-5u4nA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf5 SM80.1 VICILIN

(Solanum
melongena) 		no annotation 5 PHE A 162
ILE A 169
PHE A 173
GLY A 142
ALA A 141
 None
 1.10A 4e1gB-5vf5A:
undetectable		 4e1gB-5vf5A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf5 SM80.1 VICILIN

(Solanum
melongena) 		no annotation 5 PHE A 162
ILE A 169
PHE A 173
TYR A 150
GLY A 142
 None
 1.04A 4e1gB-5vf5A:
undetectable		 4e1gB-5vf5A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		5 PHE A 210
TYR A 416
GLY A 193
ALA A 194
LEU A 201
 None
 0.91A 4e1gB-5w1uA:
undetectable		 4e1gB-5w1uA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeq NEUROLIGIN-2

(Homo sapiens) 		PF00135
(COesterase) 		5 ILE A 380
GLY A 265
ALA A 266
SER A 269
LEU A 273
 None
 1.02A 4e1gB-5xeqA:
undetectable		 4e1gB-5xeqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica) 		no annotation 5 TYR A  29
GLY A  47
ALA A  48
GLY A 113
LEU A  40
 None
 1.07A 4e1gB-5yhpA:
undetectable		 4e1gB-5yhpA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yll BETA-1,4-MANNANASE

(Amphibacillus
xylanus) 		no annotation 5 ARG B 309
ILE B  83
GLY B 268
GLY B   6
LEU B 272
 None
 1.10A 4e1gB-5yllB:
undetectable		 4e1gB-5yllB:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 5 PHE A 379
TYR A 581
GLY A 362
ALA A 363
LEU A 370
 None
 0.91A 4e1gB-6arxA:
undetectable		 4e1gB-6arxA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0e ISOCITRATE
DEHYDROGENASE

(Legionella
pneumophila) 		no annotation 5 PHE A 414
PHE A 399
GLY A 324
GLY A 360
LEU A 364
 None
 1.10A 4e1gB-6c0eA:
undetectable		 4e1gB-6c0eA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d34 TERC

(Streptomyces) 		no annotation 5 ILE A  75
GLY A  81
ALA A  62
SER A  66
GLY A  69
 None
 1.07A 4e1gB-6d34A:
undetectable		 4e1gB-6d34A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 ILE A  43
GLY A  26
SER A  29
GLY A  33
LEU A 208
 None
 1.04A 4e1gB-6eu6A:
0.7		 4e1gB-6eu6A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 ILE A 323
GLY A 330
ALA A 167
SER A 172
GLY A 174
 None
 1.09A 4e1gB-6eu6A:
0.7		 4e1gB-6eu6A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fks -

(-) 		no annotation 5 PHE A 130
ILE A 127
GLY A 242
GLY A 245
LEU A 138
 None
 1.07A 4e1gB-6fksA:
undetectable		 4e1gB-6fksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a79 TRNA ENDONUCLEASE

(Methanocaldococcus
jannaschii) 		PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		4 VAL A 127
TYR A 128
LEU A 159
VAL A  91
 None
 0.95A 4e1gB-1a79A:
0.0		 4e1gB-1a79A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axn ANNEXIN III

(Homo sapiens) 		PF00191
(Annexin) 		4 VAL A  58
LEU A  69
MET A  85
VAL A  86
 None
 0.89A 4e1gB-1axnA:
0.0		 4e1gB-1axnA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 VAL A 233
VAL A 244
LEU A 280
VAL A 270
 None
 0.95A 4e1gB-1bhgA:
0.0		 4e1gB-1bhgA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt4 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF00266
(Aminotran_5) 		4 VAL A 251
VAL A  19
LEU A  20
ASN A 268
 None
 1.00A 4e1gB-1bt4A:
0.0		 4e1gB-1bt4A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF02463
(SMC_N) 		4 VAL A  93
LEU A 126
ASN A 103
VAL A 128
 None
 1.08A 4e1gB-1e69A:
0.2		 4e1gB-1e69A:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 VAL A 344
TYR A 348
VAL A 349
LEU A 352
ASN A 375
MET A 522
 None
None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
None
 0.31A 4e1gB-1ebvA:
58.5		 4e1gB-1ebvA:
62.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elk TARGET OF MYB1

(Homo sapiens) 		PF00790
(VHS) 		4 VAL A 113
VAL A 117
LEU A 120
VAL A  95
 None
 0.73A 4e1gB-1elkA:
undetectable		 4e1gB-1elkA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		4 VAL A  52
VAL A  56
LEU A  59
VAL A  39
 None
 0.90A 4e1gB-1fpsA:
0.6		 4e1gB-1fpsA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fx7 IRON-DEPENDENT
REPRESSOR IDER

(Mycobacterium
tuberculosis) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		4 VAL A 163
VAL A 197
ASN A 150
VAL A 189
 None
 1.08A 4e1gB-1fx7A:
undetectable		 4e1gB-1fx7A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geg ACETOIN REDUCTASE

(Klebsiella
pneumoniae) 		PF00106
(adh_short) 		4 VAL A 227
VAL A 231
LEU A 234
VAL A  82
 None
 1.10A 4e1gB-1gegA:
undetectable		 4e1gB-1gegA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi1 NEUROBEACHIN

(Homo sapiens) 		PF02138
(Beach)
PF14844
(PH_BEACH) 		4 VAL A2237
VAL A2241
LEU A2244
VAL A2247
 None
 1.02A 4e1gB-1mi1A:
undetectable		 4e1gB-1mi1A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t77 LIPOPOLYSACCHARIDE-R
ESPONSIVE AND
BEIGE-LIKE ANCHOR
PROTEIN

(Homo sapiens) 		PF02138
(Beach)
PF14844
(PH_BEACH) 		4 VAL A2173
VAL A2177
LEU A2180
VAL A2183
 None
 0.99A 4e1gB-1t77A:
undetectable		 4e1gB-1t77A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl2 ARGININOSUCCINATE
SYNTHASE

(Thermotoga
maritima) 		PF00764
(Arginosuc_synth) 		4 VAL A 356
VAL A 349
LEU A 221
ASN A  78
 None
 1.04A 4e1gB-1vl2A:
undetectable		 4e1gB-1vl2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Thermotoga
maritima) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 VAL A 425
VAL A 429
LEU A 432
VAL A  24
 None
 0.80A 4e1gB-1vrdA:
undetectable		 4e1gB-1vrdA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		4 VAL A   4
VAL A  41
LEU A  49
ASN A  59
 None
 1.07A 4e1gB-2as0A:
undetectable		 4e1gB-2as0A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		4 TYR A 536
VAL A 537
LEU A 540
VAL A 590
 None
 1.12A 4e1gB-2c4mA:
undetectable		 4e1gB-2c4mA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfc 2-(R)-HYDROXYPROPYL-
COM DEHYDROGENASE

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		4 VAL A 221
VAL A 225
LEU A 228
VAL A 136
 None
 0.98A 4e1gB-2cfcA:
undetectable		 4e1gB-2cfcA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 TYR A 259
VAL A 260
LEU A 263
VAL A 216
 None
 1.01A 4e1gB-2e8yA:
undetectable		 4e1gB-2e8yA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eih ALCOHOL
DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 304
LEU A 189
ASN A  88
VAL A 158
 None
 1.13A 4e1gB-2eihA:
undetectable		 4e1gB-2eihA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fq4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus cereus) 		PF00440
(TetR_N)
PF16859
(TetR_C_11) 		4 TYR A 177
VAL A 178
LEU A 181
ASN A 104
 None
 1.12A 4e1gB-2fq4A:
undetectable		 4e1gB-2fq4A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		4 VAL A 120
VAL A 124
ASN A 157
VAL A 146
 None
 0.83A 4e1gB-2hb6A:
undetectable		 4e1gB-2hb6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iod DIHYDROFLAVONOL
4-REDUCTASE

(Vitis vinifera) 		PF01370
(Epimerase) 		4 VAL A  10
VAL A  32
LEU A  58
ASN A 236
 None
 0.92A 4e1gB-2iodA:
undetectable		 4e1gB-2iodA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 VAL A1222
VAL A1226
LEU A1229
MET A1272
 None
 1.02A 4e1gB-2ix8A:
undetectable		 4e1gB-2ix8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 VAL A1222
VAL A1226
LEU A1229
VAL A1267
 None
 0.42A 4e1gB-2ix8A:
undetectable		 4e1gB-2ix8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhn 3-METHYLADENINE
DNA-GLYCOSYLASE

(Archaeoglobus
fulgidus) 		PF00730
(HhH-GPD) 		4 VAL A 243
VAL A 247
LEU A 250
ASN A 234
 None
None
None
GOL  A1302 (-4.3A)
 0.80A 4e1gB-2jhnA:
undetectable		 4e1gB-2jhnA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		4 VAL A  88
LEU A  91
ASN A 382
MET A 128
 None
 0.95A 4e1gB-2pq6A:
undetectable		 4e1gB-2pq6A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qwu INTRACELLULAR GROWTH
LOCUS, SUBUNIT C

(Francisella
tularensis) 		PF11550
(IglC) 		4 VAL A 202
VAL A 192
MET A  76
VAL A  20
 None
 1.12A 4e1gB-2qwuA:
undetectable		 4e1gB-2qwuA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rf0 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 10

(Homo sapiens) 		PF14604
(SH3_9) 		4 VAL A  43
VAL A  45
LEU A  46
VAL A  52
 None
 1.04A 4e1gB-2rf0A:
undetectable		 4e1gB-2rf0A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v75 NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
NAB2

(Saccharomyces
cerevisiae) 		PF11517
(Nab2) 		4 VAL A  45
VAL A  49
LEU A  52
VAL A  59
 None
 1.11A 4e1gB-2v75A:
3.3		 4e1gB-2v75A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v84 SPERMIDINE/PUTRESCIN
E ABC TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN

(Treponema
pallidum) 		PF13416
(SBP_bac_8) 		4 VAL A  66
TYR A  99
ASN A  13
VAL A 237
 None
 1.13A 4e1gB-2v84A:
undetectable		 4e1gB-2v84A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vi7 ACETYLTRANSFERASE
PA1377

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		4 VAL A 162
TYR A 128
VAL A 127
VAL A  93
 None
 1.09A 4e1gB-2vi7A:
undetectable		 4e1gB-2vi7A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		4 VAL A  90
VAL A  21
LEU A  28
ASN A 130
 None
 1.07A 4e1gB-2wedA:
undetectable		 4e1gB-2wedA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Methanothermobacter
thermautotrophicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 VAL A 155
VAL A 159
LEU A 162
VAL A 189
 None
 0.69A 4e1gB-2wnrA:
undetectable		 4e1gB-2wnrA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 VAL A 416
LEU A 419
ASN A 406
MET A 592
 None
 0.80A 4e1gB-2xy9A:
undetectable		 4e1gB-2xy9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		4 TYR A 194
VAL A 195
ASN A 516
VAL A 175
 None
 0.78A 4e1gB-2yevA:
undetectable		 4e1gB-2yevA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 VAL A 212
VAL A 216
LEU A 219
VAL A 228
 None
 0.77A 4e1gB-2yijA:
undetectable		 4e1gB-2yijA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbm PROTEIN-TYROSINE-PHO
SPHATASE

(Shewanella sp.) 		PF00149
(Metallophos) 		4 VAL A 284
VAL A 300
LEU A 295
ASN A 252
 None
 1.04A 4e1gB-2zbmA:
undetectable		 4e1gB-2zbmA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum) 		no annotation 4 VAL C 229
VAL C 233
LEU C 236
VAL C  84
 None
 1.08A 4e1gB-3a28C:
undetectable		 4e1gB-3a28C:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00196
(GerE) 		4 VAL A  50
VAL A  52
LEU A  53
MET A 194
 None
 1.00A 4e1gB-3c3wA:
undetectable		 4e1gB-3c3wA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etu PROTEIN TRANSPORT
PROTEIN DSL1

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		4 TYR A 111
VAL A 112
LEU A 115
ASN A  57
 None
 0.99A 4e1gB-3etuA:
undetectable		 4e1gB-3etuA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezq PROTEIN FADD
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 6

(Homo sapiens) 		PF00531
(Death) 		4 VAL B 158
VAL B 162
LEU B 165
ASN A 302
 None
 0.86A 4e1gB-3ezqB:
undetectable		 4e1gB-3ezqB:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)

(Sulfolobus
solfataricus) 		PF07992
(Pyr_redox_2) 		4 VAL A 213
VAL A 225
LEU A 238
VAL A 156
 None
 1.03A 4e1gB-3f8rA:
undetectable		 4e1gB-3f8rA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaa UNCHARACTERIZED
PROTEIN TA1441

(Thermoplasma
acidophilum) 		PF09754
(PAC2) 		4 VAL A 223
LEU A 226
ASN A 207
VAL A  41
 None
 0.76A 4e1gB-3gaaA:
undetectable		 4e1gB-3gaaA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbc CHOLOYLGLYCINE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF02275
(CBAH) 		4 VAL A  38
VAL A  30
ASN A  95
VAL A 178
 None
 1.08A 4e1gB-3hbcA:
undetectable		 4e1gB-3hbcA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 TYR A 236
VAL A 237
LEU A 240
VAL A 325
 GOL  A 400 (-4.7A)
None
None
None
 0.94A 4e1gB-3is5A:
undetectable		 4e1gB-3is5A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksr PUTATIVE SERINE
HYDROLASE

(Xanthomonas
campestris) 		PF00326
(Peptidase_S9) 		4 VAL A 193
TYR A 197
LEU A 128
ASN A 147
 None
None
None
PO4  A 290 (-3.0A)
 0.80A 4e1gB-3ksrA:
undetectable		 4e1gB-3ksrA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A

(Shewanella
denitrificans) 		PF00246
(Peptidase_M14) 		4 VAL A 149
VAL A 147
LEU A 146
MET A 206
 None
 1.00A 4e1gB-3l2nA:
undetectable		 4e1gB-3l2nA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP

(Vibrio cholerae) 		PF01554
(MatE) 		4 TYR A 144
VAL A 141
LEU A 145
ASN A 178
 None
 0.97A 4e1gB-3mktA:
undetectable		 4e1gB-3mktA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1k DIHYDRONEOPTERIN
ALDOLASE FOLB,
PUTATIVE

(Vibrio cholerae) 		PF02152
(FolB) 		4 VAL A  87
VAL A  91
LEU A  94
VAL A  68
 None
 0.69A 4e1gB-3o1kA:
undetectable		 4e1gB-3o1kA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouo NUCLEOPROTEIN

(Rift Valley
fever
phlebovirus) 		PF05733
(Tenui_N) 		4 VAL A 224
LEU A 223
MET A 152
VAL A 153
 None
 0.95A 4e1gB-3ouoA:
undetectable		 4e1gB-3ouoA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t02 PHOSPHONOACETATE
HYDROLASE

(Sinorhizobium
meliloti) 		PF01663
(Phosphodiest) 		4 VAL A 351
VAL A 349
LEU A 329
ASN A  71
 None
 0.95A 4e1gB-3t02A:
undetectable		 4e1gB-3t02A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 VAL A 432
VAL A 436
LEU A 439
VAL A  30
 None
 0.90A 4e1gB-3tsdA:
undetectable		 4e1gB-3tsdA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttp HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 VAL A  13
VAL A  11
LEU A  10
ASN A  88
 None
 0.73A 4e1gB-3ttpA:
undetectable		 4e1gB-3ttpA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7s POL POLYPROTEIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 VAL A  13
VAL A  11
LEU A  10
ASN A  88
 None
 0.74A 4e1gB-3u7sA:
undetectable		 4e1gB-3u7sA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens) 		PF13516
(LRR_6) 		4 VAL A 959
VAL A 963
LEU A 966
VAL A 929
 None
 0.98A 4e1gB-3un9A:
undetectable		 4e1gB-3un9A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wye DIACETYL REDUCTASE
[(S)-ACETOIN
FORMING],L-2,3-BUTAN
EDIOL
DEHYDROGENASE,DIACET
YL REDUCTASE
[(S)-ACETOIN
FORMING],L-2,3-BUTAN
EDIOL
DEHYDROGENASE,DIACET
YL REDUCTASE
[(S)-ACETOIN
FORMING],L-2,3-BUTAN
EDIOL
DEHYDROGENASE,DIACET
YL REDUCTASE
[(S)-ACETOIN
FORMING]

(Corynebacterium
glutamicum;
Klebsiella
pneumoniae) 		PF13561
(adh_short_C2) 		4 VAL A  66
VAL A  70
ASN A 136
VAL A   4
 None
 1.10A 4e1gB-3wyeA:
undetectable		 4e1gB-3wyeA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wye DIACETYL REDUCTASE
[(S)-ACETOIN
FORMING],L-2,3-BUTAN
EDIOL
DEHYDROGENASE,DIACET
YL REDUCTASE
[(S)-ACETOIN
FORMING],L-2,3-BUTAN
EDIOL
DEHYDROGENASE,DIACET
YL REDUCTASE
[(S)-ACETOIN
FORMING],L-2,3-BUTAN
EDIOL
DEHYDROGENASE,DIACET
YL REDUCTASE
[(S)-ACETOIN
FORMING]

(Corynebacterium
glutamicum;
Klebsiella
pneumoniae) 		PF13561
(adh_short_C2) 		4 VAL A 227
VAL A 231
LEU A 234
VAL A  82
 None
 1.09A 4e1gB-3wyeA:
undetectable		 4e1gB-3wyeA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		4 VAL A 500
LEU A 490
ASN A 229
VAL A 455
 None
 1.00A 4e1gB-4aioA:
undetectable		 4e1gB-4aioA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dix PLECTIN-RELATED
PROTEIN

(Arabidopsis
thaliana) 		PF16709
(SCAB-IgPH) 		4 TYR A 372
VAL A 373
LEU A 376
VAL A 406
 None
 1.14A 4e1gB-4dixA:
undetectable		 4e1gB-4dixA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dry 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		4 VAL A  69
VAL A  75
ASN A 147
MET A 134
 None
 1.12A 4e1gB-4dryA:
undetectable		 4e1gB-4dryA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dy5 GIFSY-1 PROPHAGE
PROTEIN

(Salmonella
enterica) 		PF04151
(PPC) 		4 VAL A 128
VAL A  64
ASN A  26
VAL A  84
 None
 0.94A 4e1gB-4dy5A:
undetectable		 4e1gB-4dy5A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkl ALPHA-AMYLASE

(Thermotoga
neapolitana) 		PF00128
(Alpha-amylase) 		4 VAL A 348
VAL A 363
LEU A 415
VAL A 399
 None
 1.08A 4e1gB-4gklA:
undetectable		 4e1gB-4gklA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5u PROBABLE HYDROLASE
NIT2

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		4 VAL A  26
LEU A  29
ASN A 110
VAL A  41
 None
 0.75A 4e1gB-4h5uA:
undetectable		 4e1gB-4h5uA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwc BAG FAMILY MOLECULAR
CHAPERONE REGULATOR
1

(Arabidopsis
thaliana) 		PF02179
(BAG) 		4 VAL A 227
VAL A 231
LEU A 234
VAL A 194
 None
 1.01A 4e1gB-4hwcA:
2.3		 4e1gB-4hwcA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4is2 BILE ACID 3-ALPHA
HYDROXYSTEROID
DEHYDROGENASE

([Clostridium]
scindens) 		PF00106
(adh_short) 		4 VAL A  72
VAL A  76
ASN A 141
VAL A   8
 None
 0.99A 4e1gB-4is2A:
undetectable		 4e1gB-4is2A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbh ALCOHOL
DEHYDROGENASE (ZINC)

(Pyrobaculum
aerophilum) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 191
VAL A 169
LEU A 229
VAL A 176
 None
 1.09A 4e1gB-4jbhA:
undetectable		 4e1gB-4jbhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		4 TYR A   9
VAL A  55
LEU A  58
VAL A 203
 None
 1.03A 4e1gB-4kf7A:
2.1		 4e1gB-4kf7A:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 VAL A 345
TYR A 349
VAL A 350
LEU A 353
ASN A 376
MET A 523
VAL A 524
 None
None
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
EDO  A 616 (-4.4A)
None
IBP  A 601 ( 4.0A)
 0.24A 4e1gB-4ph9A:
64.9		 4e1gB-4ph9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9x COPPER HOMEOSTASIS
PROTEIN CUTC

(Bacillus
anthracis) 		PF03932
(CutC) 		4 VAL A  54
VAL A  89
LEU A  90
VAL A 141
 None
 1.09A 4e1gB-4r9xA:
undetectable		 4e1gB-4r9xA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		4 VAL A 232
VAL A 236
LEU A 239
VAL A 137
 None
 0.85A 4e1gB-4trrA:
undetectable		 4e1gB-4trrA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up7 LYSINE--TRNA LIGASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 VAL A 547
LEU A 543
MET A 289
VAL A 290
 None
 1.07A 4e1gB-4up7A:
undetectable		 4e1gB-4up7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
fructosivorans) 		PF00374
(NiFeSe_Hases) 		4 TYR Q 266
LEU Q 270
ASN Q 438
VAL Q 407
 None
 1.12A 4e1gB-4upeQ:
undetectable		 4e1gB-4upeQ:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
fructosivorans) 		PF00374
(NiFeSe_Hases) 		4 VAL Q 262
TYR Q 266
LEU Q 270
ASN Q 438
 None
 0.76A 4e1gB-4upeQ:
undetectable		 4e1gB-4upeQ:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG

(Paracoccus
denitrificans) 		PF03150
(CCP_MauG) 		4 VAL A 339
VAL A 343
LEU A 346
ASN A 307
 None
 0.87A 4e1gB-4y5rA:
undetectable		 4e1gB-4y5rA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 TYR A 435
VAL A 441
LEU A 439
ASN A 470
 None
 1.02A 4e1gB-4ydqA:
undetectable		 4e1gB-4ydqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aov GLYOXYLATE REDUCTASE

(Pyrococcus
furiosus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A 266
ASN A  73
MET A 219
VAL A 244
 None
None
1PE  A1349 (-4.2A)
None
 1.04A 4e1gB-5aovA:
undetectable		 4e1gB-5aovA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 VAL A 184
LEU A 187
ASN A 224
VAL A 235
 None
 1.04A 4e1gB-5b25A:
undetectable		 4e1gB-5b25A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz3 NA(+)/H(+)
ANTIPORTER

(Thermus
thermophilus) 		PF00999
(Na_H_Exchanger) 		4 VAL A 334
VAL A 338
LEU A 341
VAL A 170
 None
 0.83A 4e1gB-5bz3A:
undetectable		 4e1gB-5bz3A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 VAL A 293
VAL A 297
LEU A 300
ASN A 150
 None
 0.94A 4e1gB-5d6bA:
1.0		 4e1gB-5d6bA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		4 VAL A 230
VAL A 234
LEU A 237
VAL A 210
 None
None
PG4  A 602 (-4.7A)
None
 1.06A 4e1gB-5dqfA:
5.0		 4e1gB-5dqfA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 VAL A 171
VAL A 167
LEU A 800
VAL A 788
 None
 1.12A 4e1gB-5fjiA:
undetectable		 4e1gB-5fjiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1

(Thielavia
terrestris) 		PF05183
(RdRP) 		4 VAL A 234
VAL A 167
LEU A 127
ASN A 692
 None
 0.81A 4e1gB-5fswA:
undetectable		 4e1gB-5fswA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE

(Mycobacterium
tuberculosis) 		PF02358
(Trehalose_PPase) 		4 VAL A 250
VAL A 257
LEU A 296
VAL A 230
 None
 1.13A 4e1gB-5gvxA:
undetectable		 4e1gB-5gvxA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icq METHYLOCYSTIS PARVUS
OBBP MBNE

(Methylocystis
parvus) 		PF00496
(SBP_bac_5) 		4 VAL A 554
TYR A 557
LEU A 561
ASN A 317
 None
 0.73A 4e1gB-5icqA:
undetectable		 4e1gB-5icqA:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 VAL A 344
TYR A 348
VAL A 349
ASN A 375
MET A 522
VAL A 523
 None
None
ID8  A 601 (-3.9A)
None
ID8  A 601 (-4.2A)
ID8  A 601 (-3.6A)
 0.20A 4e1gB-5ikrA:
62.5		 4e1gB-5ikrA:
87.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 VAL A 344
TYR A 348
VAL A 349
LEU A 352
ASN A 375
MET A 522
 None
None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
None
ID8  A 601 (-4.2A)
 0.58A 4e1gB-5ikrA:
62.5		 4e1gB-5ikrA:
87.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		4 TYR A 233
VAL A 234
LEU A 237
VAL A  78
 None
 1.08A 4e1gB-5l9wA:
undetectable		 4e1gB-5l9wA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mn5 CELL DIVISION
PROTEIN FTSZ

(Staphylococcus
aureus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 VAL A 129
VAL A 131
ASN A  37
VAL A 189
 None
 0.91A 4e1gB-5mn5A:
undetectable		 4e1gB-5mn5A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomyces
pombe) 		PF08638
(Med14) 		4 VAL A 428
VAL A 426
LEU A 415
ASN A 460
 None
 1.12A 4e1gB-5n9jA:
1.3		 4e1gB-5n9jA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		4 VAL A 627
VAL A 625
ASN A 513
MET A 502
 None
 0.93A 4e1gB-5nv6A:
undetectable		 4e1gB-5nv6A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sup ATP-DEPENDENT RNA
HELICASE SUB2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 VAL A 131
VAL A 209
MET A 244
VAL A 243
 None
 1.00A 4e1gB-5supA:
undetectable		 4e1gB-5supA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suq ATP-DEPENDENT RNA
HELICASE SUB2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 VAL A 131
VAL A 209
MET A 244
VAL A 243
 None
 1.00A 4e1gB-5suqA:
undetectable		 4e1gB-5suqA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 VAL B 350
VAL B 892
LEU B 896
VAL B 871
 None
 1.14A 4e1gB-5vniB:
undetectable		 4e1gB-5vniB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Trypanosoma
brucei) 		no annotation 4 VAL A 440
VAL A 444
LEU A 447
VAL A 371
 None
 1.09A 4e1gB-5x8oA:
undetectable		 4e1gB-5x8oA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 4 TYR A 515
VAL A 521
LEU A 519
ASN A 550
 None
 0.94A 4e1gB-5xiiA:
undetectable		 4e1gB-5xiiA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ

(Aspergillus
nidulans) 		no annotation 4 VAL B  80
VAL B 121
LEU B 226
VAL B  44
 None
 0.81A 4e1gB-5y7rB:
undetectable		 4e1gB-5y7rB:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0c NEROL DEHYDROGENASE

(Persicaria
minor) 		no annotation 4 VAL A 278
VAL A 276
LEU A 275
MET A 249
 None
 0.76A 4e1gB-5z0cA:
undetectable		 4e1gB-5z0cA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amn HEAT SHOCK PROTEIN
104

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A 345
VAL A 349
LEU A 352
ASN A 318
 None
 0.73A 4e1gB-6amnA:
undetectable		 4e1gB-6amnA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY

(Thermobifida
fusca) 		no annotation 4 VAL G 558
VAL G 556
LEU G 555
VAL G 553
 None
 1.13A 4e1gB-6c66G:
1.0		 4e1gB-6c66G:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 4 TYR A 950
VAL A 763
LEU A 767
VAL A 742
 None
 0.88A 4e1gB-6d6yA:
2.1		 4e1gB-6d6yA:
9.14