SIMILAR PATTERNS OF AMINO ACIDS FOR 4E1G_A_LNLA701_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ay2 TYPE 4 PILIN

(Neisseria
gonorrhoeae) 		PF00114
(Pilin) 		4 ARG A 127
VAL A  88
LEU A 108
SER A 107
 None
 1.33A 4e1gA-1ay2A:
undetectable		 4e1gA-1ay2A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		4 ARG A 343
VAL A 381
LEU A 399
SER A 398
 None
 1.29A 4e1gA-1dabA:
undetectable		 4e1gA-1dabA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcu FRUCTOSE-1,6-BISPHOS
PHATASE

(Pisum sativum) 		PF00316
(FBPase) 		4 ARG A 279
VAL A 274
LEU A 273
SER A 272
 None
 1.21A 4e1gA-1dcuA:
0.0		 4e1gA-1dcuA:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 ARG A 120
VAL A 349
LEU A 352
SER A 353
MET A 522
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
None
 0.38A 4e1gA-1ebvA:
58.5		 4e1gA-1ebvA:
62.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsh DISHEVELLED-1

(Mus musculus) 		PF00610
(DEP) 		4 ARG A  38
VAL A 102
LEU A  86
MET A  28
 None
 1.27A 4e1gA-1fshA:
0.0		 4e1gA-1fshA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ARG A 165
VAL A 392
LEU A 419
SER A 420
 OXL  A1583 ( 2.8A)
NAP  A1581 (-4.3A)
NAP  A1581 (-4.4A)
NAP  A1581 ( 3.9A)
 1.26A 4e1gA-1gq2A:
0.0		 4e1gA-1gq2A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 ARG S 437
VAL S 609
LEU S 612
SER S 611
 None
 1.28A 4e1gA-1i84S:
0.0		 4e1gA-1i84S:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihb CYCLIN-DEPENDENT
KINASE 6 INHIBITOR

(Homo sapiens) 		PF13637
(Ank_4)
PF13857
(Ank_5) 		4 ARG A 145
VAL A 152
LEU A 155
SER A 154
 None
 1.17A 4e1gA-1ihbA:
undetectable		 4e1gA-1ihbA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 ARG A 580
VAL A 543
LEU A 544
SER A 541
 None
 1.21A 4e1gA-1jqoA:
0.1		 4e1gA-1jqoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juh QUERCETIN
2,3-DIOXYGENASE

(Aspergillus
japonicus) 		no annotation 4 VAL A  97
LEU A  98
SER A  99
MET A 123
 None
None
None
EDO  A2028 (-4.7A)
 1.25A 4e1gA-1juhA:
0.0		 4e1gA-1juhA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1b B-CELL LYMPHOMA
3-ENCODED PROTEIN

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 ARG A 311
VAL A 284
LEU A 281
SER A 280
 None
 1.16A 4e1gA-1k1bA:
0.9		 4e1gA-1k1bA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kjw POSTSYNAPTIC DENSITY
PROTEIN 95

(Rattus
norvegicus) 		PF00018
(SH3_1)
PF00625
(Guanylate_kin) 		4 ARG A 497
VAL A 520
LEU A 521
SER A 522
 None
 0.74A 4e1gA-1kjwA:
undetectable		 4e1gA-1kjwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.) 		PF07859
(Abhydrolase_3) 		4 ARG A 107
VAL A  70
LEU A  51
SER A  50
 None
 1.13A 4e1gA-1lzkA:
undetectable		 4e1gA-1lzkA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		4 ARG A 320
VAL A 287
LEU A 290
SER A 289
 None
 1.13A 4e1gA-1mt5A:
undetectable		 4e1gA-1mt5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9i MANGANESE CATALASE

(Lactobacillus
plantarum) 		PF05067
(Mn_catalase) 		4 ARG A 147
LEU A  29
SER A  28
MET A  67
 MN3  A 268 (-4.3A)
None
None
None
 1.04A 4e1gA-1o9iA:
undetectable		 4e1gA-1o9iA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1

(Sus scrofa) 		PF01909
(NTP_transf_2)
PF10421
(OAS1_C) 		4 ARG A   9
VAL A 340
LEU A 339
SER A 338
 None
 0.93A 4e1gA-1px5A:
undetectable		 4e1gA-1px5A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r62 NITROGEN REGULATION
PROTEIN NR(II)

(Escherichia
coli) 		PF02518
(HATPase_c) 		4 ARG A 222
VAL A 210
LEU A 214
SER A 211
 None
 1.26A 4e1gA-1r62A:
undetectable		 4e1gA-1r62A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tue REPLICATION PROTEIN
E1

(Alphapapillomavirus
7) 		PF00519
(PPV_E1_C) 		4 ARG A 434
LEU A 627
SER A 625
MET A 429
 None
 1.14A 4e1gA-1tueA:
undetectable		 4e1gA-1tueA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wox HEME OXYGENASE 2

(Synechocystis
sp. PCC 6803) 		PF01126
(Heme_oxygenase) 		4 ARG A 167
LEU A 137
SER A 136
MET A 155
 None
 1.30A 4e1gA-1woxA:
undetectable		 4e1gA-1woxA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yis ADENYLOSUCCINATE
LYASE

(Caenorhabditis
elegans) 		PF00206
(Lyase_1) 		4 ARG A 153
VAL A 162
LEU A 161
SER A 160
 None
 1.32A 4e1gA-1yisA:
undetectable		 4e1gA-1yisA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykd ADENYLATE CYCLASE

(Anabaena sp.) 		PF01590
(GAF) 		4 ARG A 362
VAL A 385
LEU A 366
SER A 365
 None
 1.03A 4e1gA-1ykdA:
undetectable		 4e1gA-1ykdA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3d UBIQUITIN-CONJUGATIN
G ENZYME E2 1

(Caenorhabditis
elegans) 		PF00179
(UQ_con) 		4 VAL A  70
LEU A  55
SER A  56
MET A  76
 None
 1.27A 4e1gA-1z3dA:
undetectable		 4e1gA-1z3dA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ARG A 155
VAL A 379
LEU A 406
SER A 407
 None
 1.31A 4e1gA-2aw5A:
undetectable		 4e1gA-2aw5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE

(Vitis vinifera) 		PF00201
(UDPGT) 		4 ARG A 312
VAL A 289
LEU A 292
SER A 293
 None
 1.16A 4e1gA-2c1zA:
undetectable		 4e1gA-2c1zA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw3 IRON SUPEROXIDE
DISMUTASE

(Perkinsus
marinus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 ARG A  66
VAL A  60
LEU A 156
SER A 157
 None
 1.27A 4e1gA-2cw3A:
undetectable		 4e1gA-2cw3A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7u ADENYLOSUCCINATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00709
(Adenylsucc_synt) 		4 ARG A 213
VAL A 173
LEU A 172
SER A 171
 None
 1.12A 4e1gA-2d7uA:
undetectable		 4e1gA-2d7uA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddu REELIN

(Mus musculus) 		no annotation 4 ARG A1454
VAL A1471
LEU A1484
SER A1483
 None
 1.33A 4e1gA-2dduA:
undetectable		 4e1gA-2dduA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h7v PROTEIN KINASE YPKA

(Yersinia
pseudotuberculosis) 		PF09632
(Rac1) 		4 ARG C 545
VAL C 539
LEU C 470
SER C 471
 None
 1.31A 4e1gA-2h7vC:
undetectable		 4e1gA-2h7vC:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwk HELICASE NSP2

(Venezuelan
equine
encephalitis
virus) 		PF01707
(Peptidase_C9) 		4 VAL A 563
LEU A 566
SER A 567
MET A 585
 None
 1.01A 4e1gA-2hwkA:
undetectable		 4e1gA-2hwkA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6u ORNITHINE
CARBAMOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 VAL A 176
LEU A 151
SER A 152
MET A 161
 None
 1.31A 4e1gA-2i6uA:
undetectable		 4e1gA-2i6uA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id1 HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum) 		PF02410
(RsfS) 		4 VAL A  80
LEU A  79
SER A  69
MET A  90
 None
 1.38A 4e1gA-2id1A:
undetectable		 4e1gA-2id1A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		4 ARG G 376
VAL G 414
LEU G 432
SER G 431
 None
 1.30A 4e1gA-2iouG:
undetectable		 4e1gA-2iouG:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooc HISTIDINE
PHOSPHOTRANSFERASE

(Caulobacter
vibrioides) 		PF01627
(Hpt) 		4 ARG A  76
VAL A  87
LEU A  84
SER A  83
 None
None
PG4  A 113 ( 4.7A)
GOL  A 114 (-3.8A)
 1.34A 4e1gA-2oocA:
undetectable		 4e1gA-2oocA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqc PENICILLIN V ACYLASE

(Bacillus
subtilis) 		PF02275
(CBAH) 		4 ARG A 228
VAL A 172
LEU A   4
SER A   3
 None
 1.38A 4e1gA-2oqcA:
undetectable		 4e1gA-2oqcA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owz FRUCTOSE-1,6-BISPHOS
PHATASE

(Escherichia
coli) 		PF00316
(FBPase) 		4 ARG A 249
VAL A 244
LEU A 243
SER A 242
 None
None
F6P  A 603 (-4.3A)
F6P  A 603 ( 4.7A)
 1.26A 4e1gA-2owzA:
undetectable		 4e1gA-2owzA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 ARG A 297
VAL A 301
LEU A 302
SER A 299
 None
 1.22A 4e1gA-2p4qA:
undetectable		 4e1gA-2p4qA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE

(Nostoc
punctiforme) 		PF00497
(SBP_bac_3) 		4 ARG A  32
VAL A  16
LEU A  17
SER A  18
 None
 1.14A 4e1gA-2pyyA:
undetectable		 4e1gA-2pyyA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyy N-PAC PROTEIN

(Homo sapiens) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 VAL A 400
LEU A 399
SER A 388
MET A 360
 None
 1.32A 4e1gA-2uyyA:
undetectable		 4e1gA-2uyyA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 ARG A 365
VAL A 418
LEU A 415
SER A 414
 None
 0.99A 4e1gA-2wpgA:
undetectable		 4e1gA-2wpgA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		PF00073
(Rhv)
no annotation 		4 ARG 3  34
VAL 1  30
LEU 1  34
SER 1  31
 None
 1.37A 4e1gA-2ws93:
undetectable		 4e1gA-2ws93:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		4 ARG A 329
VAL A 261
LEU A 285
SER A 287
 None
 1.36A 4e1gA-2zwvA:
undetectable		 4e1gA-2zwvA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq2 6B PROTEIN

(Agrobacterium
vitis) 		PF02027
(RolB_RolC) 		4 ARG A  28
VAL A  39
LEU A  38
SER A  36
 None
 1.33A 4e1gA-3aq2A:
undetectable		 4e1gA-3aq2A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		4 VAL A  98
LEU A  99
SER A 100
MET A  73
 None
 1.31A 4e1gA-3breA:
undetectable		 4e1gA-3breA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpr DIHYDRODIPICOLINATE
SYNTHETASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		4 ARG A 228
VAL A  22
LEU A  54
SER A  53
 None
 1.18A 4e1gA-3cprA:
undetectable		 4e1gA-3cprA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		4 ARG A 709
VAL A 341
LEU A 340
SER A 339
 None
 1.32A 4e1gA-3cskA:
0.4		 4e1gA-3cskA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		4 ARG A 364
VAL A 417
LEU A 414
SER A 413
 None
 0.99A 4e1gA-3czeA:
undetectable		 4e1gA-3czeA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0e REPLICATION PROTEIN
A

(Methanococcus
maripaludis) 		PF01336
(tRNA_anti-codon) 		4 VAL A  75
LEU A  11
SER A  12
MET A   0
 None
 1.27A 4e1gA-3e0eA:
undetectable		 4e1gA-3e0eA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		4 VAL A 581
LEU A 566
SER A 567
MET A 540
 None
 1.19A 4e1gA-3f70A:
undetectable		 4e1gA-3f70A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghy KETOPANTOATE
REDUCTASE PROTEIN

(Ralstonia
solanacearum) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 ARG A 224
VAL A 214
LEU A 217
SER A 215
 None
 1.17A 4e1gA-3ghyA:
undetectable		 4e1gA-3ghyA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SARZ

(Staphylococcus
aureus) 		PF01047
(MarR) 		4 VAL A  82
LEU A  98
SER A  97
MET A  45
 None
None
None
BT6  A   1 (-4.7A)
 1.36A 4e1gA-3hsrA:
undetectable		 4e1gA-3hsrA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ARG A 257
VAL A 561
LEU A 564
SER A 562
 None
 1.35A 4e1gA-3iayA:
undetectable		 4e1gA-3iayA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivf TALIN-1

(Mus musculus) 		PF00373
(FERM_M)
PF02174
(IRS)
PF09379
(FERM_N)
PF16511
(FERM_f0) 		4 VAL A 130
LEU A 129
SER A 128
MET A  92
 None
 1.37A 4e1gA-3ivfA:
undetectable		 4e1gA-3ivfA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Brucella
abortus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A 395
LEU A 396
SER A 392
MET A 343
 None
 1.36A 4e1gA-3k5pA:
undetectable		 4e1gA-3k5pA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke5 HYPOTHETICAL
CYTOSOLIC PROTEIN

(Bacillus cereus) 		PF01923
(Cob_adeno_trans) 		4 ARG A 133
VAL A 152
LEU A 155
SER A 156
 None
None
None
MG  A 204 ( 4.3A)
 1.36A 4e1gA-3ke5A:
undetectable		 4e1gA-3ke5A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN

(Salmonella
enterica) 		PF00291
(PALP) 		4 ARG B 131
LEU B 128
SER B 104
MET B 187
 None
 1.22A 4e1gA-3pr2B:
undetectable		 4e1gA-3pr2B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC) 		4 VAL A1249
LEU A1252
SER A1250
MET A 849
 None
 1.31A 4e1gA-3ptaA:
undetectable		 4e1gA-3ptaA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sao EXTRACELLULAR FATTY
ACID-BINDING PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		4 ARG A 116
VAL A  48
LEU A  46
SER A  39
 None
 1.01A 4e1gA-3saoA:
undetectable		 4e1gA-3saoA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		4 ARG A 129
VAL A 103
LEU A 104
SER A 102
 EPZ  A 518 (-4.0A)
None
None
None
 1.30A 4e1gA-3swgA:
undetectable		 4e1gA-3swgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA

(Streptococcus
pneumoniae) 		PF02481
(DNA_processg_A) 		4 ARG A 210
VAL A 164
LEU A 191
SER A 192
 None
 0.90A 4e1gA-3uqzA:
undetectable		 4e1gA-3uqzA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		4 ARG A 612
VAL A 714
LEU A 743
SER A 713
 None
 1.25A 4e1gA-3welA:
undetectable		 4e1gA-3welA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdr ALCOHOL
DEHYDROGENASE DOMAIN
OF THE BIFUNCTIONAL
ACETALDEHYDE
DEHYDROGENASE

(Parageobacillus
thermoglucosidasius) 		PF00465
(Fe-ADH) 		4 VAL A 799
LEU A 802
SER A 801
MET A 752
 None
 1.37A 4e1gA-3zdrA:
undetectable		 4e1gA-3zdrA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Lactobacillus
acidophilus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 VAL A 471
LEU A 470
SER A 469
MET A 345
 None
 1.10A 4e1gA-4aieA:
undetectable		 4e1gA-4aieA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		4 VAL A 529
LEU A 532
SER A 533
MET A 627
 None
 0.98A 4e1gA-4bl3A:
undetectable		 4e1gA-4bl3A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egf L-XYLULOSE REDUCTASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 ARG A  87
VAL A  44
LEU A  45
SER A  46
 None
 1.23A 4e1gA-4egfA:
undetectable		 4e1gA-4egfA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcj THIJ/PFPI DOMAIN
PROTEIN

(Brachyspira
murdochii) 		PF01965
(DJ-1_PfpI) 		4 ARG A  86
VAL A  62
LEU A  57
SER A  38
 CL  A 204 (-4.3A)
None
None
None
 1.23A 4e1gA-4hcjA:
undetectable		 4e1gA-4hcjA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 VAL A 871
LEU A 874
SER A 872
MET A 794
 None
 1.20A 4e1gA-4knhA:
undetectable		 4e1gA-4knhA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0p RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE 1

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 VAL A 309
LEU A 312
SER A 310
MET A 127
 SO4  A1001 (-3.9A)
None
SO4  A1001 (-2.8A)
None
 1.26A 4e1gA-4m0pA:
undetectable		 4e1gA-4m0pA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjd KETOSTEROID
ISOMERASE FOLD
PROTEIN HMUK_0747

(Halomicrobium
mukohataei) 		PF12680
(SnoaL_2) 		4 VAL A  25
LEU A  26
SER A  23
MET A  49
 None
 1.24A 4e1gA-4mjdA:
undetectable		 4e1gA-4mjdA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofe METHYL-CPG-BINDING
DOMAIN PROTEIN 4

(Homo sapiens) 		no annotation 4 ARG A 512
VAL A 499
LEU A 502
SER A 500
 None
 1.32A 4e1gA-4ofeA:
undetectable		 4e1gA-4ofeA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pgw UNCHARACTERIZED
PROTEIN YETJ

(Bacillus
subtilis) 		PF01027
(Bax1-I) 		4 VAL A 187
LEU A 190
SER A 191
MET A  52
 None
None
PT  A 301 ( 4.9A)
None
 1.36A 4e1gA-4pgwA:
undetectable		 4e1gA-4pgwA:
17.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 ARG A 121
VAL A 350
LEU A 353
SER A 354
MET A 523
 BOG  A 604 ( 3.7A)
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
None
None
 0.20A 4e1gA-4ph9A:
64.6		 4e1gA-4ph9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv6 N-TERMINAL
ACETYLTRANSFERASE
COMPLEX SUBUNIT
[ARD1]

(Thermoplasma
volcanium) 		no annotation 4 ARG C 152
LEU C 102
SER C 101
MET C 108
 None
 1.28A 4e1gA-4pv6C:
undetectable		 4e1gA-4pv6C:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		4 ARG A 191
VAL A 187
LEU A 166
SER A 167
 None
 1.04A 4e1gA-4v2dA:
undetectable		 4e1gA-4v2dA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 ARG A 334
VAL A 469
LEU A 472
SER A 471
 None
FAD  A 701 (-4.9A)
None
None
 1.22A 4e1gA-4y9lA:
0.0		 4e1gA-4y9lA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9i SOLUTE CARRIER
FAMILY 15 MEMBER 2

(Rattus
norvegicus) 		no annotation 4 ARG A 549
VAL A 539
LEU A 527
SER A 538
 None
 1.30A 4e1gA-5a9iA:
undetectable		 4e1gA-5a9iA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8g PP-BRD20

(Trypanosoma
brucei) 		PF00439
(Bromodomain) 		4 ARG A  78
LEU A  66
SER A  65
MET A  86
 None
 0.90A 4e1gA-5c8gA:
undetectable		 4e1gA-5c8gA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed4 RESPONSE REGULATOR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 ARG A 231
VAL A 218
LEU A 221
SER A 219
 None
 1.20A 4e1gA-5ed4A:
undetectable		 4e1gA-5ed4A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig9 ATP GRASP LIGASE

(Microcystis
aeruginosa) 		no annotation 4 ARG A  31
VAL A  18
LEU A  17
SER A  14
 None
 1.37A 4e1gA-5ig9A:
undetectable		 4e1gA-5ig9A:
19.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 ARG A 120
VAL A 349
SER A 353
MET A 522
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-4.2A)
 0.28A 4e1gA-5ikrA:
62.6		 4e1gA-5ikrA:
87.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 VAL A 349
LEU A 352
SER A 353
MET A 522
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-4.2A)
 0.71A 4e1gA-5ikrA:
62.6		 4e1gA-5ikrA:
87.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz1 FRUCTOSE-1,6-BISPHOS
PHATASE

(Physcomitrella
patens) 		PF00316
(FBPase) 		4 ARG A 347
VAL A 342
LEU A 341
SER A 340
 None
 1.18A 4e1gA-5iz1A:
undetectable		 4e1gA-5iz1A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE

(Cryptococcus
neoformans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 ARG A 643
VAL A 559
LEU A 563
SER A 561
 EDO  A 708 (-3.4A)
None
None
None
 1.29A 4e1gA-5k8fA:
undetectable		 4e1gA-5k8fA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m89 SPLICEOSOME WD40 SC

(Chaetomium
thermophilum) 		no annotation 4 ARG A 468
VAL A 218
LEU A 209
SER A 208
 None
 0.82A 4e1gA-5m89A:
undetectable		 4e1gA-5m89A:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjv CAPSID SUBUNIT VP0
CAPSID SUBUNIT VP3

(Parechovirus A) 		PF00073
(Rhv)
no annotation 		4 ARG C 132
LEU B 143
SER B 144
MET B  82
 None
 1.32A 4e1gA-5mjvC:
undetectable		 4e1gA-5mjvC:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqd POLYCOMB PROTEIN PCL

(Drosophila
melanogaster) 		no annotation 4 ARG B 611
VAL B 580
LEU B 581
MET B 629
 None
 1.32A 4e1gA-5oqdB:
undetectable		 4e1gA-5oqdB:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Thermus
thermophilus) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 VAL A 305
LEU A 308
SER A 306
MET A 128
 None
 1.38A 4e1gA-5t3oA:
undetectable		 4e1gA-5t3oA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 ARG A 512
LEU A 588
SER A 589
MET A 581
 None
 1.15A 4e1gA-5t8vA:
undetectable		 4e1gA-5t8vA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ARG A 529
VAL A 171
LEU A 125
SER A 172
 None
 1.38A 4e1gA-5tf0A:
undetectable		 4e1gA-5tf0A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 ARG A 343
VAL A 274
LEU A 269
SER A 272
 None
 1.18A 4e1gA-5thmA:
undetectable		 4e1gA-5thmA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Brucella canis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ARG A 541
VAL A 461
LEU A 465
SER A 463
 None
 1.26A 4e1gA-5u2aA:
undetectable		 4e1gA-5u2aA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 ARG A 518
VAL A 347
LEU A 350
SER A 351
 None
 0.90A 4e1gA-5u47A:
undetectable		 4e1gA-5u47A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5b HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CMR

(Mycobacterium
tuberculosis) 		no annotation 4 ARG A  82
VAL A  50
LEU A  53
SER A  51
 None
 1.24A 4e1gA-5w5bA:
0.1		 4e1gA-5w5bA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ARG B 490
VAL B 751
LEU B 485
SER B 482
 G  P   8 ( 4.7A)
None
None
None
 1.33A 4e1gA-5xogB:
undetectable		 4e1gA-5xogB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anr COLIBACTIN
SELF-PROTECTION
PROTEIN CLBS

(Escherichia
coli) 		no annotation 4 ARG A 111
VAL A  53
LEU A  56
SER A  54
 None
 1.20A 4e1gA-6anrA:
undetectable		 4e1gA-6anrA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6auj THYMIDYLATE SYNTHASE

(Elizabethkingia
anophelis) 		PF00303
(Thymidylat_synt) 		4 VAL A 204
LEU A  46
SER A  47
MET A 238
 None
 1.21A 4e1gA-6aujA:
0.2		 4e1gA-6aujA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avo PROTEASOME SUBUNIT
BETA TYPE-8

(Homo sapiens) 		no annotation 4 ARG C  19
VAL C 192
LEU C 196
SER C 193
 None
 1.38A 4e1gA-6avoC:
undetectable		 4e1gA-6avoC:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Mus musculus) 		no annotation 4 ARG B 644
VAL B 586
LEU B 590
SER B 588
 None
 1.31A 4e1gA-6bcqB:
undetectable		 4e1gA-6bcqB:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 4 ARG A 523
VAL A 246
LEU A 239
SER A 240
 None
 1.24A 4e1gA-6es9A:
0.0		 4e1gA-6es9A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh8 -

(-) 		no annotation 4 ARG A 138
VAL A  59
LEU A  32
SER A  34
 None
 1.34A 4e1gA-6gh8A:
undetectable		 4e1gA-6gh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		4 VAL B 624
LEU B 627
SER B 628
MET B 501
 None
 0.72A 4e1gA-6reqB:
undetectable		 4e1gA-6reqB:
22.55