SIMILAR PATTERNS OF AMINO ACIDS FOR 4E0F_A_RBFA301_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0a ASPARTYL TRNA
SYNTHETASE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 LYS A 167
THR A 169
ILE A 505
 None
A  B 676 ( 3.6A)
None
 0.58A 4e0fB-1c0aA:
2.0		 4e0fB-1c0aA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgf CATALASE

(Homo sapiens) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 LYS A  77
THR A 115
ILE A 205
 None
 0.72A 4e0fB-1dgfA:
0.0		 4e0fB-1dgfA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dzb SCFV FRAGMENT 1F9

(Mus musculus) 		PF07686
(V-set) 		3 LYS A 239
THR A 284
ILE A 275
 None
 0.78A 4e0fB-1dzbA:
1.0		 4e0fB-1dzbA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1c HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		3 LYS A 202
THR A 199
ILE A  88
 PLP  A1202 (-1.3A)
PLP  A1202 (-3.3A)
None
 0.84A 4e0fB-1h1cA:
0.6		 4e0fB-1h1cA:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i8d RIBOFLAVIN SYNTHASE

(Escherichia
coli) 		PF00677
(Lum_binding) 		3 LYS A 137
THR A 148
ILE A 162
 None
 0.34A 4e0fB-1i8dA:
29.8		 4e0fB-1i8dA:
36.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jik TYROSYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00579
(tRNA-synt_1b) 		3 LYS A 305
THR A 304
ILE A 257
 None
 0.92A 4e0fB-1jikA:
0.0		 4e0fB-1jikA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzu LIPOCALIN Q83

(Coturnix
coturnix) 		PF00061
(Lipocalin) 		3 LYS A  93
THR A  90
ILE A 128
 None
 0.88A 4e0fB-1jzuA:
undetectable		 4e0fB-1jzuA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kej TERMINAL
DEOXYNUCLEOTIDYLTRAN
SFERASE SHORT
ISOFORM

(Mus musculus) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		3 LYS A 199
THR A 169
ILE A 174
 None
 0.89A 4e0fB-1kejA:
0.0		 4e0fB-1kejA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgd PERIPHERAL PLASMA
MEMBRANE CASK

(Homo sapiens) 		PF00625
(Guanylate_kin) 		3 LYS A 757
THR A 753
ILE A 894
 None
 0.94A 4e0fB-1kgdA:
0.0		 4e0fB-1kgdA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lsh LIPOVITELLIN (LV-1N,
LV-1C)

(Ichthyomyzon
unicuspis) 		PF01347
(Vitellogenin_N)
PF09172
(DUF1943) 		3 LYS A 881
THR A 876
ILE A 288
 None
 0.93A 4e0fB-1lshA:
undetectable		 4e0fB-1lshA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mfw DOUBLECORTIN-LIKE
KINASE (N-TERMINAL
DOMAIN)

(Homo sapiens) 		PF03607
(DCX) 		3 LYS A 116
THR A 107
ILE A 134
 SO4  A1002 (-3.5A)
None
SO4  A1001 (-4.3A)
 0.84A 4e0fB-1mfwA:
undetectable		 4e0fB-1mfwA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		3 LYS A 379
THR A 380
ILE A 422
 None
 0.93A 4e0fB-1mhsA:
undetectable		 4e0fB-1mhsA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 LYS A 616
THR A 695
ILE A 752
 None
 0.91A 4e0fB-1n7rA:
undetectable		 4e0fB-1n7rA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg5 ORF, HYPOTHETICAL
PROTEIN

(Escherichia
coli) 		PF07073
(ROF) 		3 LYS A  37
THR A  29
ILE A  78
 None
 0.93A 4e0fB-1sg5A:
undetectable		 4e0fB-1sg5A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 LYS A  56
THR A  94
ILE A 184
 None
 0.71A 4e0fB-1si8A:
undetectable		 4e0fB-1si8A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		3 LYS A  78
THR A  82
ILE A 104
 None
 0.85A 4e0fB-1xfuA:
undetectable		 4e0fB-1xfuA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii) 		PF01266
(DAO) 		3 LYS B 145
THR B  49
ILE B 229
 None
None
FMN  A 802 ( 4.1A)
 0.90A 4e0fB-1y56B:
undetectable		 4e0fB-1y56B:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx7 DIHYDROOROTATE
DEHYDROGENASE

(Lactococcus
lactis) 		PF01180
(DHO_dh) 		3 LYS A 276
THR A 272
ILE A 224
 None
FMN  A1312 (-3.7A)
FMN  A1312 ( 4.9A)
 0.88A 4e0fB-2bx7A:
undetectable		 4e0fB-2bx7A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cai GLUTATHIONE
S-TRANSFERASE 28 KDA

(Schistosoma
haematobium) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 LYS A 175
THR A 171
ILE A 164
 None
 0.87A 4e0fB-2caiA:
undetectable		 4e0fB-2caiA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cr9 POLY [ADP-RIBOSE]
POLYMERASE-1

(Homo sapiens) 		PF05406
(WGR) 		3 LYS A  54
THR A  56
ILE A  86
 None
 0.90A 4e0fB-2cr9A:
undetectable		 4e0fB-2cr9A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE

(Oryza sativa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 LYS A 146
THR A 151
ILE A 164
 CSO  A 145 ( 3.6A)
None
None
 0.79A 4e0fB-2cvoA:
undetectable		 4e0fB-2cvoA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dt8 DEGV FAMILY PROTEIN

(Thermus
thermophilus) 		PF02645
(DegV) 		3 LYS A 191
THR A 189
ILE A 211
 GOL  A 601 (-2.9A)
GOL  A 601 (-4.0A)
None
 0.88A 4e0fB-2dt8A:
undetectable		 4e0fB-2dt8A:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5o ACTIVATING SIGNAL
COINTEGRATOR 1

(Homo sapiens) 		PF04266
(ASCH) 		3 LYS A  47
THR A  45
ILE A  42
 None
 0.93A 4e0fB-2e5oA:
undetectable		 4e0fB-2e5oA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		3 LYS A 133
THR A 136
ILE A 161
 None
 0.83A 4e0fB-2gv8A:
undetectable		 4e0fB-2gv8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqf CATALASE

(Helicobacter
pylori) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 LYS A  58
THR A  96
ILE A 186
 None
 0.82A 4e0fB-2iqfA:
undetectable		 4e0fB-2iqfA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isa CATALASE

(Aliivibrio
salmonicida) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 LYS A  56
THR A  94
ILE A 184
 None
 0.76A 4e0fB-2isaA:
undetectable		 4e0fB-2isaA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph5 HOMOSPERMIDINE
SYNTHASE

(Legionella
pneumophila) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 LYS A 306
THR A 304
ILE A 297
 None
 0.82A 4e0fB-2ph5A:
undetectable		 4e0fB-2ph5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk9 PHO85 CYCLIN PHO80

(Saccharomyces
cerevisiae) 		PF08613
(Cyclin) 		3 LYS B  86
THR B  85
ILE B  39
 None
 0.90A 4e0fB-2pk9B:
undetectable		 4e0fB-2pk9B:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prv UNCHARACTERIZED
PROTEIN YOBK

(Bacillus
subtilis) 		PF14567
(SUKH_5) 		3 LYS A  78
THR A  74
ILE A  31
 EDO  A 159 (-3.4A)
None
None
 0.82A 4e0fB-2prvA:
undetectable		 4e0fB-2prvA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puq TISSUE FACTOR

(Homo sapiens) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		3 LYS T  28
THR T  55
ILE T  22
 None
 0.88A 4e0fB-2puqT:
undetectable		 4e0fB-2puqT:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA

(Mus musculus;
Paraburkholderia
xenovorans) 		PF01007
(IRK) 		3 LYS A  11
THR A 261
ILE A 217
 None
 0.90A 4e0fB-2qksA:
0.6		 4e0fB-2qksA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0s LR1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		3 LYS A 201
THR A 192
ILE A 221
 None
 0.91A 4e0fB-2v0sA:
undetectable		 4e0fB-2v0sA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus) 		PF00294
(PfkB) 		3 LYS A 175
THR A 179
ILE A 150
 None
 0.77A 4e0fB-2varA:
undetectable		 4e0fB-2varA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8k HYPOTHETICAL PROTEIN
19.1

(Bacillus phage
SPP1) 		PF05709
(Sipho_tail) 		3 LYS A 251
THR A 249
ILE A 203
 None
 0.82A 4e0fB-2x8kA:
1.9		 4e0fB-2x8kA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 LYS A 716
THR A 720
ILE A 590
 None
 0.68A 4e0fB-2xaxA:
undetectable		 4e0fB-2xaxA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0e UDP-GLUCOSE
DEHYDROGENASE

(Burkholderia
cepacia) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		3 LYS A 331
THR A 334
ILE A  46
 UGA  A 501 (-2.7A)
None
None
 0.91A 4e0fB-2y0eA:
undetectable		 4e0fB-2y0eA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8c DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Plasmodium
falciparum) 		PF00692
(dUTPase) 		3 LYS A  96
THR A  97
ILE A 130
 None
 0.76A 4e0fB-2y8cA:
undetectable		 4e0fB-2y8cA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio) 		PF00514
(Arm) 		3 LYS A 334
THR A 338
ILE A 302
 None
 0.85A 4e0fB-2z6gA:
undetectable		 4e0fB-2z6gA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a74 LYSYL-TRNA
SYNTHETASE

(Geobacillus
stearothermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 LYS A  36
THR A  83
ILE A 175
 None
 0.79A 4e0fB-3a74A:
undetectable		 4e0fB-3a74A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9v 4-COUMARATE--COA
LIGASE

(Populus
tomentosa) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LYS A 394
THR A 199
ILE A 175
 None
 0.86A 4e0fB-3a9vA:
undetectable		 4e0fB-3a9vA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akz GLUTAMYL-TRNA
SYNTHETASE 2

(Thermotoga
maritima) 		no annotation 3 LYS B 455
THR B 458
ILE B 365
 None
U  F  35 ( 4.9A)
None
 0.79A 4e0fB-3akzB:
undetectable		 4e0fB-3akzB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq1 THERMOSOME SUBUNIT

(Methanococcoides
burtonii) 		PF00118
(Cpn60_TCP1) 		3 LYS B 395
THR B 131
ILE B 126
 None
 0.86A 4e0fB-3aq1B:
undetectable		 4e0fB-3aq1B:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5n PROTEIN TRANSPORT
PROTEIN SEC9
SYNAPTOBREVIN
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00957
(Synaptobrevin)
no annotation 		3 LYS A  26
THR A  29
ILE D 594
 None
 0.91A 4e0fB-3b5nA:
undetectable		 4e0fB-3b5nA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9g UPF0200/UPF0201
PROTEIN AF_1395

(Archaeoglobus
fulgidus) 		PF01877
(RNA_binding) 		3 LYS A 287
THR A 195
ILE A 221
 None
 0.89A 4e0fB-3c9gA:
undetectable		 4e0fB-3c9gA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cux MALATE SYNTHASE

(Bacillus
anthracis) 		PF01274
(Malate_synthase) 		3 LYS A 311
THR A 315
ILE A  70
 None
 0.88A 4e0fB-3cuxA:
undetectable		 4e0fB-3cuxA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyk HEMAGGLUTININ HA1
CHAIN
HEMAGGLUTININ HA2
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 LYS A  40
THR A 322
ILE B  45
 None
 0.90A 4e0fB-3eykA:
undetectable		 4e0fB-3eykA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3o VACUOLAR TRANSPORTER
CHAPERONE 2

(Saccharomyces
cerevisiae) 		PF09359
(VTC) 		3 LYS A 275
THR A 405
ILE A 421
 None
 0.81A 4e0fB-3g3oA:
undetectable		 4e0fB-3g3oA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grp 3-OXOACYL-(ACYL
CARRIERPROTEIN)
REDUCTASE

(Bartonella
henselae) 		PF13561
(adh_short_C2) 		3 LYS A 156
THR A 138
ILE A 216
 None
 0.80A 4e0fB-3grpA:
undetectable		 4e0fB-3grpA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvz UNCHARACTERIZED
PROTEIN CV2077

(Chromobacterium
violaceum) 		PF03417
(AAT) 		3 LYS A  26
THR A 174
ILE A 189
 None
 0.91A 4e0fB-3gvzA:
undetectable		 4e0fB-3gvzA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1

(Schizosaccharomyces
pombe) 		PF00498
(FHA) 		3 LYS A 171
THR A 173
ILE A 118
 None
 0.85A 4e0fB-3i0mA:
undetectable		 4e0fB-3i0mA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53

(Homo sapiens) 		PF00270
(DEAD) 		3 LYS A 281
THR A 282
ILE A 359
 None
AMP  A 160 (-3.5A)
None
 0.93A 4e0fB-3iuyA:
undetectable		 4e0fB-3iuyA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7v PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1377C

(Streptococcus
mutans) 		PF01300
(Sua5_yciO_yrdC) 		3 LYS A   0
THR A   2
ILE A  18
 None
 0.82A 4e0fB-3l7vA:
undetectable		 4e0fB-3l7vA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnb N-ACETYLTRANSFERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00797
(Acetyltransf_2) 		3 LYS A 246
THR A 239
ILE A 221
 COA  A1001 (-2.6A)
COA  A1001 (-3.9A)
COA  A1001 ( 3.8A)
 0.81A 4e0fB-3lnbA:
undetectable		 4e0fB-3lnbA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m51 14-3-3-LIKE PROTEIN
C

(Nicotiana
tabacum) 		PF00244
(14-3-3) 		3 LYS A 220
THR A 224
ILE A 209
 None
 0.69A 4e0fB-3m51A:
undetectable		 4e0fB-3m51A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msu CITRATE SYNTHASE

(Francisella
tularensis) 		PF00285
(Citrate_synt) 		3 LYS A 219
THR A 223
ILE A  79
 None
 0.85A 4e0fB-3msuA:
undetectable		 4e0fB-3msuA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		3 LYS A 330
THR A 333
ILE A 309
 None
 0.77A 4e0fB-3nawA:
undetectable		 4e0fB-3nawA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oe7 ATP SYNTHASE SUBUNIT
GAMMA

(Saccharomyces
cerevisiae) 		PF00231
(ATP-synt) 		3 LYS G   1
THR G 258
ILE G 253
 None
 0.90A 4e0fB-3oe7G:
undetectable		 4e0fB-3oe7G:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oos ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		3 LYS A 215
THR A 109
ILE A  77
 None
 0.82A 4e0fB-3oosA:
undetectable		 4e0fB-3oosA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		3 LYS A 383
THR A 382
ILE A 351
 None
 0.92A 4e0fB-3psiA:
undetectable		 4e0fB-3psiA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LYS A 429
THR A 171
ILE A 229
 None
 0.73A 4e0fB-3qtpA:
undetectable		 4e0fB-3qtpA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr6 O-METHYLTRANSFERASE

(Coxiella
burnetii) 		PF01596
(Methyltransf_3) 		3 LYS A 147
THR A 150
ILE A 167
 NI  A 223 ( 4.1A)
None
None
 0.88A 4e0fB-3tr6A:
undetectable		 4e0fB-3tr6A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		3 LYS A1400
THR A1383
ILE A1514
 None
 0.92A 4e0fB-4a5wA:
2.2		 4e0fB-4a5wA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3

(Homo sapiens) 		PF01299
(Lamp) 		3 LYS A 278
THR A 293
ILE A 322
 NAG  A1379 ( 4.5A)
NAG  A1379 (-2.7A)
None
 0.92A 4e0fB-4akmA:
undetectable		 4e0fB-4akmA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq4 SN-GLYCEROL-3-PHOSPH
ATE-BINDING
PERIPLASMIC PROTEIN
UGPB

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		3 LYS A 293
THR A 297
ILE A  34
 None
 0.91A 4e0fB-4aq4A:
undetectable		 4e0fB-4aq4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		3 LYS A1050
THR A 955
ILE A 962
 None
 0.83A 4e0fB-4bfrA:
undetectable		 4e0fB-4bfrA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		3 LYS A 152
THR A 201
ILE A 107
 None
 0.79A 4e0fB-4c30A:
undetectable		 4e0fB-4c30A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx0 14-3-3-LIKE PROTEIN
E

(Nicotiana
tabacum) 		PF00244
(14-3-3) 		3 LYS A 218
THR A 222
ILE A 207
 None
 0.64A 4e0fB-4dx0A:
undetectable		 4e0fB-4dx0A:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep0 MAJOR TAIL PROTEIN

(Streptococcus
virus C1) 		PF16838
(Caud_tail_N) 		3 LYS A 343
THR A 339
ILE A 364
 None
 0.84A 4e0fB-4ep0A:
0.2		 4e0fB-4ep0A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 3 LYS A 313
THR A 318
ILE A 323
 CL  A 502 ( 3.9A)
None
None
 0.86A 4e0fB-4eziA:
undetectable		 4e0fB-4eziA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kp2 HOMOACONITASE LARGE
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		3 LYS A 217
THR A 131
ILE A 141
 None
 0.49A 4e0fB-4kp2A:
undetectable		 4e0fB-4kp2A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		3 LYS A1464
THR A1145
ILE A1140
 None
 0.93A 4e0fB-4ll8A:
undetectable		 4e0fB-4ll8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE

(Acinetobacter
baumannii) 		PF00348
(polyprenyl_synt) 		3 LYS A 238
THR A 240
ILE A 216
 None
 0.85A 4e0fB-4lobA:
undetectable		 4e0fB-4lobA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN

(Helicobacter
pylori) 		PF01497
(Peripla_BP_2) 		3 LYS A 172
THR A 176
ILE A 310
 None
 0.79A 4e0fB-4ls3A:
undetectable		 4e0fB-4ls3A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		3 LYS A 566
THR A 522
ILE A 539
 None
 0.91A 4e0fB-4madA:
2.0		 4e0fB-4madA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Thermosynechococcus
elongatus) 		PF06745
(ATPase) 		3 LYS A 404
THR A 400
ILE A 430
 None
None
SEP  A 431 ( 3.7A)
 0.88A 4e0fB-4o0mA:
undetectable		 4e0fB-4o0mA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7k ABC TRANSPORTER

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		3 LYS A 527
THR A 530
ILE A 508
 None
 0.77A 4e0fB-4q7kA:
undetectable		 4e0fB-4q7kA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		3 LYS A 409
THR A 639
ILE A 634
 AMP  A 777 (-2.9A)
None
None
 0.77A 4e0fB-4v1uA:
undetectable		 4e0fB-4v1uA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620) 		no annotation 3 LYS A 599
THR A 571
ILE A 514
 None
 0.80A 4e0fB-4xn3A:
3.1		 4e0fB-4xn3A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxz LEVOGLUCOSAN KINASE

(Lipomyces
starkeyi) 		PF03702
(AnmK) 		3 LYS A 361
THR A 365
ILE A 379
 None
 0.93A 4e0fB-4zxzA:
undetectable		 4e0fB-4zxzA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus) 		PF01398
(JAB) 		3 LYS H 156
THR H 157
ILE H 330
 None
 0.93A 4e0fB-5a5tH:
undetectable		 4e0fB-5a5tH:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LYS A 396
THR A 202
ILE A 178
 None
 0.91A 4e0fB-5bswA:
undetectable		 4e0fB-5bswA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE

(Geobacillus
stearothermophilus) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		3 LYS A 121
THR A 125
ILE A  10
 None
 0.85A 4e0fB-5c3mA:
undetectable		 4e0fB-5c3mA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d79 BERBERINE BRIDGE
ENZYME-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 LYS A 257
THR A 303
ILE A 173
 None
 0.89A 4e0fB-5d79A:
undetectable		 4e0fB-5d79A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6n PROTEIN LGG-2

(Caenorhabditis
elegans) 		PF02991
(Atg8) 		3 LYS A 101
THR A  69
ILE A  76
 None
 0.92A 4e0fB-5e6nA:
undetectable		 4e0fB-5e6nA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN

(Streptococcus
suis) 		PF05833
(FbpA) 		3 LYS A 134
THR A 117
ILE A  91
 None
 0.87A 4e0fB-5h3xA:
undetectable		 4e0fB-5h3xA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC

(Escherichia
coli) 		PF09344
(Cas_CT1975) 		3 LYS D 354
THR D 252
ILE D  58
 None
 0.94A 4e0fB-5h9fD:
undetectable		 4e0fB-5h9fD:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 LYS A 592
THR A 589
ILE A 186
 None
 0.91A 4e0fB-5ihrA:
undetectable		 4e0fB-5ihrA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz1 FRUCTOSE-1,6-BISPHOS
PHATASE

(Physcomitrella
patens) 		PF00316
(FBPase) 		3 LYS A  98
THR A  94
ILE A  89
 None
 0.89A 4e0fB-5iz1A:
undetectable		 4e0fB-5iz1A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 LYS A 427
THR A 933
ILE A 898
 None
 0.85A 4e0fB-5j6sA:
1.3		 4e0fB-5j6sA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		3 LYS A 514
THR A 512
ILE A 498
 None
 0.94A 4e0fB-5jcfA:
undetectable		 4e0fB-5jcfA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		3 LYS A 747
THR A 751
ILE A 320
 None
 0.92A 4e0fB-5jjrA:
undetectable		 4e0fB-5jjrA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9q HEMAGGLUTININ HA2

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 LYS B 121
THR B 122
ILE B 149
 None
 0.92A 4e0fB-5k9qB:
undetectable		 4e0fB-5k9qB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		3 LYS A 330
THR A 331
ILE A 374
 ACP  A 904 ( 4.8A)
ACP  A 904 (-3.4A)
ACP  A 904 (-4.3A)
 0.91A 4e0fB-5ksdA:
undetectable		 4e0fB-5ksdA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR A

(Homo sapiens) 		no annotation 3 LYS A   6
THR A   9
ILE A  38
 None
 0.92A 4e0fB-5l3xA:
undetectable		 4e0fB-5l3xA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldd RAB SMALL MONOMERIC
GTPASE-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00071
(Ras) 		3 LYS C 161
THR C 156
ILE C 127
 None
 0.81A 4e0fB-5lddC:
undetectable		 4e0fB-5lddC:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 3 LYS A  86
THR A  78
ILE A 278
 None
 0.77A 4e0fB-5opqA:
undetectable		 4e0fB-5opqA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 3 LYS A 752
THR A 754
ILE A 833
 None
 0.91A 4e0fB-5vhaA:
undetectable		 4e0fB-5vhaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW

(Bacillus
subtilis) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2) 		3 LYS A  68
THR A  71
ILE A 158
 None
 0.92A 4e0fB-5wuqA:
undetectable		 4e0fB-5wuqA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xr6 RAS-RELATED PROTEIN
RABA1A

(Arabidopsis
thaliana) 		no annotation 3 LYS A  76
THR A  79
ILE A  19
 None
 0.88A 4e0fB-5xr6A:
undetectable		 4e0fB-5xr6A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h25 -

(-) 		no annotation 3 LYS A  21
THR A  29
ILE A 253
 None
 0.76A 4e0fB-6h25A:
undetectable		 4e0fB-6h25A:
undetectable