SIMILAR PATTERNS OF AMINO ACIDS FOR 4E0F_A_RBFA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bk6 KARYOPHERIN ALPHA

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 THR A 238
TRP A 195
ALA A 159
THR A 166
VAL A 170
 None
 1.15A 4e0fA-1bk6A:
undetectable		 4e0fA-1bk6A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		5 SER A 424
VAL A 408
LEU A 365
ALA A 410
VAL A 389
 None
 1.25A 4e0fA-1cu1A:
0.0		 4e0fA-1cu1A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1few SECOND
MITOCHONDRIA-DERIVED
ACTIVATOR OF
CASPASES

(Homo sapiens) 		PF09057
(Smac_DIABLO) 		5 SER A  29
VAL A  23
GLU A 114
ALA A 116
THR A 119
 None
 1.19A 4e0fA-1fewA:
undetectable		 4e0fA-1fewA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g73 SECOND
MITOCHONDRIA-DERIVED
ACTIVATOR OF
CASPASES

(Homo sapiens) 		PF09057
(Smac_DIABLO) 		5 SER A  29
VAL A  23
THR A  30
ALA A 115
THR A 119
 None
 1.22A 4e0fA-1g73A:
undetectable		 4e0fA-1g73A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7g 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Escherichia
coli) 		PF02348
(CTP_transf_3) 		5 VAL A 142
THR A 139
GLU A 216
THR A 214
VAL A 144
 None
 1.21A 4e0fA-1h7gA:
0.0		 4e0fA-1h7gA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli) 		PF00923
(TAL_FSA) 		5 SER A 176
VAL A 172
LEU A 155
THR A 156
ALA A 143
 None
 1.04A 4e0fA-1i2oA:
0.0		 4e0fA-1i2oA:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i8d RIBOFLAVIN SYNTHASE

(Escherichia
coli) 		PF00677
(Lum_binding) 		5 LEU A 147
THR A 148
GLU A 164
THR A 169
VAL A   6
 None
 0.56A 4e0fA-1i8dA:
28.7		 4e0fA-1i8dA:
36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i8d RIBOFLAVIN SYNTHASE

(Escherichia
coli) 		PF00677
(Lum_binding) 		6 SER A  41
CYH A  48
LEU A  49
THR A  50
GLU A  66
THR A  71
 None
 0.66A 4e0fA-1i8dA:
28.7		 4e0fA-1i8dA:
36.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermotoga
maritima) 		PF00218
(IGPS) 		5 SER A 229
VAL A 203
LEU A 199
GLU A 187
ALA A 186
 None
 1.04A 4e0fA-1j5tA:
undetectable		 4e0fA-1j5tA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermotoga
maritima) 		PF00218
(IGPS) 		5 VAL A 203
LEU A 199
GLU A 187
ALA A 186
VAL A 184
 None
 1.09A 4e0fA-1j5tA:
undetectable		 4e0fA-1j5tA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr6 HELICASE NS3

(Hepacivirus C) 		PF00271
(Helicase_C) 		5 SER A  98
VAL A  82
LEU A  39
ALA A  84
VAL A  63
 None
 1.15A 4e0fA-1jr6A:
0.0		 4e0fA-1jr6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k94 GRANCALCIN

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13833
(EF-hand_8) 		5 SER A 136
VAL A 131
THR A 138
ALA A 147
HIS A 142
 CA  A 998 (-2.4A)
None
None
None
None
 1.25A 4e0fA-1k94A:
undetectable		 4e0fA-1k94A:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kzl RIBOFLAVIN SYNTHASE

(Schizosaccharomyces
pombe) 		PF00677
(Lum_binding) 		8 SER A  41
CYH A  48
LEU A  49
THR A  50
GLU A  66
THR A  71
HIS A 102
VAL A 103
 CRM  A 502 ( 4.0A)
HG  A1001 ( 2.5A)
CRM  A 502 (-4.4A)
CRM  A 502 (-3.9A)
None
None
CRM  A 502 (-4.2A)
CRM  A 502 (-4.0A)
 0.70A 4e0fA-1kzlA:
29.1		 4e0fA-1kzlA:
36.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 VAL A 789
THR A1070
ALA A 769
THR A 772
VAL A 764
 None
 1.18A 4e0fA-1n5xA:
0.0		 4e0fA-1n5xA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		5 SER A 239
VAL A 217
LEU A 241
GLU A 244
ALA A 245
 None
 1.19A 4e0fA-1oznA:
0.0		 4e0fA-1oznA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 THR B 232
TRP B 184
ALA B 148
THR B 155
VAL B 159
 None
 1.20A 4e0fA-1pjmB:
undetectable		 4e0fA-1pjmB:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1s 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Escherichia
coli) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 SER A   8
VAL A  96
LEU A   6
ALA A  88
VAL A  93
 None
 1.22A 4e0fA-1t1sA:
undetectable		 4e0fA-1t1sA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A 236
GLU A  52
ALA A  51
THR A  34
VAL A  49
 None
 1.03A 4e0fA-1tqyA:
undetectable		 4e0fA-1tqyA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 LEU A  57
THR A  56
ALA A 354
THR A  35
VAL A 365
 None
 0.96A 4e0fA-1ufaA:
undetectable		 4e0fA-1ufaA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		5 VAL A 189
LEU A 191
ALA A 211
THR A 215
VAL A 182
 None
 1.13A 4e0fA-1vefA:
undetectable		 4e0fA-1vefA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1

(Saccharomyces
cerevisiae) 		PF02463
(SMC_N) 		5 VAL A  49
LEU A  50
GLU A 106
ALA A  96
VAL A  94
 None
 1.13A 4e0fA-1w1wA:
undetectable		 4e0fA-1w1wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3k CYTOPLASMIC PROTEIN
NCK2

(Homo sapiens) 		PF00017
(SH2) 		5 SER A  39
VAL A   8
LEU A  27
ALA A  16
HIS A  11
 None
 1.19A 4e0fA-1z3kA:
undetectable		 4e0fA-1z3kA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bqx INORGANIC
PYROPHOSPHATASE

(Helicobacter
pylori) 		PF00719
(Pyrophosphatase) 		5 SER A   9
VAL A  17
CYH A  16
LEU A  15
ALA A 106
 None
 1.20A 4e0fA-2bqxA:
undetectable		 4e0fA-2bqxA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6w PENICILLIN-BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 SER B 389
VAL B 394
LEU B 421
THR B 390
ALA B 424
 None
 1.23A 4e0fA-2c6wB:
undetectable		 4e0fA-2c6wB:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 SER A  63
VAL A  75
ALA A  10
THR A  83
HIS A  73
 None
 1.19A 4e0fA-2e8yA:
2.4		 4e0fA-2e8yA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekj COLLAGEN ALPHA-1(XX)
CHAIN

(Homo sapiens) 		PF00041
(fn3) 		5 SER A  53
VAL A  56
LEU A  40
THR A  41
HIS A  37
 None
 1.17A 4e0fA-2ekjA:
0.9		 4e0fA-2ekjA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		5 SER A 265
LEU A 267
THR A 268
HIS A  16
VAL A  14
 None
 1.07A 4e0fA-2gt1A:
undetectable		 4e0fA-2gt1A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iml HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF04289
(DUF447) 		5 VAL A 136
LEU A 140
GLU A 182
ALA A 180
VAL A 169
 None
FMN  A 200 (-3.9A)
None
None
None
 1.11A 4e0fA-2imlA:
undetectable		 4e0fA-2imlA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k31 PHOSPHODIESTERASE
5A, CGMP-SPECIFIC

(Mus musculus) 		PF01590
(GAF) 		5 SER A 192
VAL A 180
LEU A 190
ALA A 224
VAL A 268
 None
 1.25A 4e0fA-2k31A:
undetectable		 4e0fA-2k31A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kig INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE II
ISOFORM

(Mus musculus) 		PF16776
(INPP5B_PH) 		5 SER A  38
VAL A  72
LEU A  40
ALA A  11
THR A  15
 None
 1.11A 4e0fA-2kigA:
undetectable		 4e0fA-2kigA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nps SYNTAXIN 13
VESICLE TRANSPORT
THROUGH INTERACTION
WITH T-SNARES
HOMOLOG 1A
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 4

(Mus musculus;
Rattus
norvegicus) 		PF00957
(Synaptobrevin)
PF05739
(SNARE)
PF12352
(V-SNARE_C) 		5 LEU A  92
GLU B 224
THR C 170
HIS B 229
VAL B 230
 None
 1.15A 4e0fA-2npsA:
undetectable		 4e0fA-2npsA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3i HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum) 		PF06032
(DUF917) 		5 VAL A 187
LEU A 191
GLU A 167
ALA A 156
VAL A 170
 None
 1.04A 4e0fA-2o3iA:
undetectable		 4e0fA-2o3iA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocd L-ASPARAGINASE I

(Vibrio cholerae) 		PF00710
(Asparaginase) 		5 VAL A 269
LEU A 271
THR A 272
GLU A 334
ALA A 306
 None
 1.16A 4e0fA-2ocdA:
undetectable		 4e0fA-2ocdA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogp PARTITIONING-DEFECTI
VE 3 HOMOLOG

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 SER A  96
VAL A  90
LEU A  94
THR A  97
GLU A  76
 None
 1.01A 4e0fA-2ogpA:
undetectable		 4e0fA-2ogpA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra8 UNCHARACTERIZED
PROTEIN Q64V53_BACFR

(Bacteroides
fragilis) 		PF05406
(WGR) 		5 VAL A   6
LEU A  32
GLU A  70
ALA A  73
THR A  68
 None
 1.11A 4e0fA-2ra8A:
undetectable		 4e0fA-2ra8A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		5 SER A 235
VAL A 231
THR A 236
HIS A 174
VAL A 173
 None
None
None
ZN  A1006 (-3.2A)
None
 1.03A 4e0fA-2z00A:
undetectable		 4e0fA-2z00A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		5 VAL A 438
LEU A 471
THR A 472
GLU A 445
VAL A 441
 None
 1.14A 4e0fA-2z6hA:
undetectable		 4e0fA-2z6hA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccq 50S RIBOSOMAL
PROTEIN L4P

(Haloarcula
marismortui) 		PF00573
(Ribosomal_L4) 		5 SER C 238
LEU C 240
THR C 236
GLU C  15
ALA C   3
 None
 1.13A 4e0fA-3ccqC:
undetectable		 4e0fA-3ccqC:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Burkholderia
pseudomallei) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 CYH A 232
LEU A 231
GLU A 270
ALA A 248
VAL A 246
 None
 1.24A 4e0fA-3dahA:
undetectable		 4e0fA-3dahA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		5 SER A  68
VAL A  65
LEU A 117
THR A 118
VAL A 114
 None
 1.13A 4e0fA-3e53A:
undetectable		 4e0fA-3e53A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5z PUTATIVE
GLUCONOLACTONASE

(Deinococcus
radiodurans) 		PF08450
(SGL) 		5 LEU A 242
THR A 243
TRP A 232
ALA A 233
THR A 220
 None
 1.18A 4e0fA-3e5zA:
undetectable		 4e0fA-3e5zA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezq PROTEIN FADD
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 6

(Homo sapiens) 		PF00531
(Death) 		5 VAL B 180
GLU B  95
ALA B  99
THR A 235
VAL A 239
 None
 0.95A 4e0fA-3ezqB:
undetectable		 4e0fA-3ezqB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		5 VAL 3 615
LEU 3 351
THR 3 350
GLU 3 545
ALA 3 546
 None
 1.22A 4e0fA-3i9v3:
undetectable		 4e0fA-3i9v3:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igx TRANSALDOLASE

(Francisella
tularensis) 		PF00923
(TAL_FSA) 		5 SER A 179
VAL A 175
LEU A 158
THR A 159
ALA A 146
 None
 1.03A 4e0fA-3igxA:
undetectable		 4e0fA-3igxA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iie 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Yersinia
pseudotuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 SER A   9
VAL A  97
LEU A   7
ALA A  89
VAL A  94
 None
 1.21A 4e0fA-3iieA:
undetectable		 4e0fA-3iieA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 C381 TURRET PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 5 SER P 361
VAL P 365
THR P 362
THR P 308
VAL P 311
 None
 1.10A 4e0fA-3j31P:
undetectable		 4e0fA-3j31P:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnp AMIDOHYDROLASE
FAMILY PROTEIN
OLEI01672_1_465

(Oleispira
antarctica) 		PF01979
(Amidohydro_1) 		5 SER A 141
THR A 143
GLU A 132
ALA A 163
THR A 443
 None
 1.06A 4e0fA-3lnpA:
undetectable		 4e0fA-3lnpA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		5 SER A 157
VAL A 194
LEU A 159
GLU A 182
ALA A 180
 None
 1.17A 4e0fA-3m8yA:
undetectable		 4e0fA-3m8yA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 VAL A 434
LEU A 435
ALA A 128
HIS A 449
VAL A 453
 None
IMD  A 513 ( 4.0A)
None
GOL  A 522 (-4.4A)
None
 1.18A 4e0fA-3pfeA:
undetectable		 4e0fA-3pfeA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q80 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01128
(IspD) 		5 SER A  48
VAL A  42
LEU A  46
ALA A  74
VAL A  12
 None
 1.21A 4e0fA-3q80A:
undetectable		 4e0fA-3q80A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv0 MITOCHONDRIAL ACIDIC
PROTEIN MAM33

(Saccharomyces
cerevisiae) 		PF02330
(MAM33) 		5 LEU A  88
GLU A  96
ALA A  97
HIS A 110
VAL A 111
 None
 1.03A 4e0fA-3qv0A:
undetectable		 4e0fA-3qv0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 VAL C 789
THR C1070
ALA C 769
THR C 772
VAL C 764
 None
 1.15A 4e0fA-3sr6C:
undetectable		 4e0fA-3sr6C:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w79 FMN-DEPENDENT
NADH-AZOREDUCTASE

(Bacillus sp.
B29) 		PF02525
(Flavodoxin_2) 		5 VAL A 175
LEU A 170
THR A 168
GLU A 179
ALA A 141
 None
 1.24A 4e0fA-3w79A:
undetectable		 4e0fA-3w79A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyd LC-EST1C

(uncultured
organism) 		PF00326
(Peptidase_S9) 		5 VAL A 422
ALA A 483
THR A 486
HIS A 443
VAL A 442
 None
 1.22A 4e0fA-3wydA:
undetectable		 4e0fA-3wydA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkb DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 VAL A  54
LEU A 204
THR A 205
GLU A 196
THR A 307
 None
 1.22A 4e0fA-3zkbA:
undetectable		 4e0fA-3zkbA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		5 SER A 733
VAL A 728
LEU A 731
GLU A 693
ALA A 691
 None
 1.24A 4e0fA-4b8bA:
undetectable		 4e0fA-4b8bA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)

(Clostridioides
difficile) 		PF00112
(Peptidase_C1) 		5 SER A 443
VAL A 430
LEU A 445
THR A 444
VAL A 383
 None
 1.16A 4e0fA-4ci7A:
undetectable		 4e0fA-4ci7A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)

(Clostridioides
difficile) 		PF00112
(Peptidase_C1) 		5 SER A 443
VAL A 430
LEU A 445
THR A 444
VAL A 383
 None
 1.15A 4e0fA-4d59A:
undetectable		 4e0fA-4d59A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em7 DNA TOPOISOMERASE
IV, B SUBUNIT

(Streptococcus
pneumoniae) 		PF02518
(HATPase_c) 		5 SER A 210
VAL A 207
GLU A  55
ALA A  56
HIS A  79
 None
None
0RA  A 301 (-3.4A)
None
None
 1.09A 4e0fA-4em7A:
0.4		 4e0fA-4em7A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em7 DNA TOPOISOMERASE
IV, B SUBUNIT

(Streptococcus
pneumoniae) 		PF02518
(HATPase_c) 		5 SER A 210
VAL A 207
LEU A 209
GLU A  55
HIS A  79
 None
None
None
0RA  A 301 (-3.4A)
None
 0.97A 4e0fA-4em7A:
0.4		 4e0fA-4em7A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4w DNA POLYMERASE IV

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		5 VAL A 336
GLU A 315
ALA A 312
HIS A 286
VAL A 287
 None
 1.22A 4e0fA-4f4wA:
undetectable		 4e0fA-4f4wA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3t OXIDOREDUCTASE DPRE1

(Mycolicibacterium
smegmatis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		5 LEU A 168
THR A 169
TRP A 179
THR A 188
VAL A 451
 None
 1.23A 4e0fA-4g3tA:
undetectable		 4e0fA-4g3tA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm6 PFKB FAMILY
CARBOHYDRATE KINASE

(Listeria grayi) 		PF00294
(PfkB) 		5 SER A 109
VAL A  56
LEU A  86
ALA A  65
VAL A  79
 None
 1.14A 4e0fA-4gm6A:
undetectable		 4e0fA-4gm6A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 SER A 384
VAL A 317
LEU A 360
TRP A 361
ALA A 353
 None
 1.23A 4e0fA-4h53A:
undetectable		 4e0fA-4h53A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2h INTRACELLULAR
PROTEASE/AMIDASE

(Salmonella
enterica) 		PF01965
(DJ-1_PfpI) 		5 VAL A   6
LEU A   8
GLU A  16
ALA A  17
VAL A  68
 None
 1.15A 4e0fA-4k2hA:
undetectable		 4e0fA-4k2hA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw5 OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		5 LEU A 161
THR A 162
TRP A 172
THR A 181
VAL A 444
 None
 1.23A 4e0fA-4kw5A:
undetectable		 4e0fA-4kw5A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY

(Yersinia
frederiksenii) 		PF01758
(SBF) 		5 SER A  59
GLU A 254
ALA A  67
THR A  68
VAL A 128
 None
 1.19A 4e0fA-4n7wA:
undetectable		 4e0fA-4n7wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4piv FATTY ACID SYNTHASE

(Homo sapiens) 		PF08242
(Methyltransf_12)
PF08659
(KR) 		5 SER A1942
VAL A1939
LEU A1914
THR A1915
ALA A1901
 None
None
None
NDP  A2202 (-4.5A)
None
 1.16A 4e0fA-4pivA:
undetectable		 4e0fA-4pivA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl3 CHITINASE A

(Pteris
ryukyuensis) 		PF00704
(Glyco_hydro_18) 		5 SER A 362
LEU A 365
THR A 364
ALA A 338
VAL A 352
 None
 1.13A 4e0fA-4rl3A:
undetectable		 4e0fA-4rl3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxp NS3-4 PROTEASE

(Hepacivirus C) 		PF07652
(Flavi_DEAD) 		5 SER A 424
VAL A 408
LEU A 365
ALA A 410
VAL A 389
 None
 1.16A 4e0fA-4wxpA:
undetectable		 4e0fA-4wxpA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Actinomyces
urogenitalis) 		PF00977
(His_biosynth) 		5 SER A 216
VAL A 219
LEU A   4
THR A   3
HIS A  48
 None
PO4  A 301 ( 4.7A)
None
None
PO4  A 303 (-4.1A)
 1.11A 4e0fA-4x2rA:
undetectable		 4e0fA-4x2rA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
vulgaris) 		PF03480
(DctP) 		5 VAL A  44
THR A  41
GLU A  57
ALA A  56
HIS A  77
 None
 1.25A 4e0fA-4xeqA:
undetectable		 4e0fA-4xeqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yr1 ALKALINE PHOSPHATASE

(Escherichia
coli) 		PF00245
(Alk_phosphatase) 		5 VAL A 321
LEU A  48
GLU A 347
ALA A 348
THR A 303
 None
 1.21A 4e0fA-4yr1A:
undetectable		 4e0fA-4yr1A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 VAL A 461
LEU A 395
ALA A 463
THR A 503
VAL A 501
 None
 1.13A 4e0fA-4zo6A:
undetectable		 4e0fA-4zo6A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 SER A1706
VAL A1133
ALA A1276
THR A1280
HIS A1294
 None
None
None
None
ZN  A3001 (-3.1A)
 1.14A 4e0fA-5a22A:
undetectable		 4e0fA-5a22A:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 VAL A 291
THR A 270
GLU A 281
ALA A 283
HIS A 295
 None
 1.16A 4e0fA-5b25A:
undetectable		 4e0fA-5b25A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Streptomyces
halstedii) 		no annotation 5 SER A 266
VAL A 259
LEU A 263
ALA A 113
VAL A 244
 None
 1.14A 4e0fA-5czcA:
undetectable		 4e0fA-5czcA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		5 VAL A 144
LEU A  89
THR A  88
ALA A  95
THR A  98
 None
 1.19A 4e0fA-5djqA:
undetectable		 4e0fA-5djqA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		5 LEU A 554
THR A 555
GLU A 608
ALA A 609
HIS A 475
 None
 1.20A 4e0fA-5f7uA:
1.5		 4e0fA-5f7uA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f89 CAP248-2B LIGHT
CHAIN

(Homo sapiens) 		no annotation 5 SER L 100
VAL L  97
LEU L   4
THR L   5
THR L  92
 None
 1.24A 4e0fA-5f89L:
undetectable		 4e0fA-5f89L:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9q MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN YKNZ

(Bacillus
amyloliquefaciens) 		PF12704
(MacB_PCD) 		5 VAL A 181
LEU A  20
GLU A 195
ALA A 196
VAL A  55
 None
 1.25A 4e0fA-5f9qA:
1.2		 4e0fA-5f9qA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1

(Caenorhabditis
elegans;
Homo sapiens) 		PF00090
(TSP_1)
PF10250
(O-FucT) 		5 VAL A  64
LEU A 197
THR A 196
GLU A 218
ALA A 217
 None
 1.25A 4e0fA-5foeA:
undetectable		 4e0fA-5foeA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN

(Escherichia
coli) 		PF00466
(Ribosomal_L10) 		5 LEU i   9
THR i   6
GLU i  40
ALA i  37
VAL i  43
 None
 1.21A 4e0fA-5gafi:
undetectable		 4e0fA-5gafi:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx9 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		5 VAL A 225
THR A 219
ALA A 281
THR A 285
VAL A 249
 None
 1.24A 4e0fA-5hx9A:
undetectable		 4e0fA-5hx9A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 SER A1667
VAL A1787
LEU A1767
GLU A1790
ALA A1833
 None
 1.03A 4e0fA-5i6gA:
undetectable		 4e0fA-5i6gA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 SER A1667
VAL A1787
LEU A1767
GLU A1790
ALA A1833
 None
 1.06A 4e0fA-5i6hA:
undetectable		 4e0fA-5i6hA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 SER A1667
VAL A1787
LEU A1767
GLU A1790
ALA A1833
 None
 0.98A 4e0fA-5i6iA:
undetectable		 4e0fA-5i6iA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9h ENVELOPMENT
POLYPROTEIN

(Puumala
orthohantavirus) 		PF01561
(Hanta_G2) 		5 LEU A 856
THR A 855
GLU A 725
ALA A 724
HIS A 728
 None
 1.20A 4e0fA-5j9hA:
undetectable		 4e0fA-5j9hA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgg ALPHA CHAIN

(Acipenser
persicus) 		PF00042
(Globin) 		5 SER A  85
VAL A 133
LEU A  81
THR A  82
HIS A 135
 None
 1.04A 4e0fA-5jggA:
undetectable		 4e0fA-5jggA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 VAL A 301
THR A  38
GLU A 338
HIS A 297
VAL A 298
 None
 1.17A 4e0fA-5kufA:
undetectable		 4e0fA-5kufA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 VAL A 773
CYH A 774
LEU A 775
THR A 776
GLU A 824
 None
 1.20A 4e0fA-5l46A:
1.5		 4e0fA-5l46A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 5 VAL A  87
LEU A 110
GLU A  84
ALA A  51
THR A  53
 None
 1.22A 4e0fA-5oynA:
undetectable		 4e0fA-5oynA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy4 CHAPERONE YAJL

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		5 VAL A   7
LEU A   9
GLU A  17
ALA A  18
VAL A  71
 None
 1.24A 4e0fA-5sy4A:
undetectable		 4e0fA-5sy4A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvk C-PHYCOCYANIN ALPHA
CHAIN

(Thermosynechococcus
elongatus) 		PF00502
(Phycobilisome) 		5 VAL A  95
LEU A  44
THR A  45
GLU A 149
ALA A 150
 None
 1.25A 4e0fA-5uvkA:
undetectable		 4e0fA-5uvkA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1j THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Echinococcus
granulosus) 		no annotation 5 VAL A 292
CYH A 291
LEU A 290
THR A 289
VAL A 391
 None
 0.98A 4e0fA-5w1jA:
undetectable		 4e0fA-5w1jA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 5 SER A 424
VAL A 408
LEU A 365
ALA A 410
VAL A 389
 None
 1.13A 4e0fA-5wdxA:
undetectable		 4e0fA-5wdxA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 5 VAL A  56
LEU A  54
THR A  53
GLU A  40
ALA A  38
 None
 1.23A 4e0fA-6cipA:
undetectable		 4e0fA-6cipA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft -

(-) 		no annotation 5 SER B 291
VAL B 280
ALA B 317
HIS B 314
VAL B 313
 NAD  A 502 ( 3.1A)
None
NAD  B 500 (-3.6A)
None
None
 1.07A 4e0fA-6dftB:
undetectable		 4e0fA-6dftB:
undetectable