SIMILAR PATTERNS OF AMINO ACIDS FOR 4E0F_A_RBFA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bk6 KARYOPHERIN ALPHA

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 THR A 238
TRP A 195
ALA A 159
THR A 166
VAL A 170
 None
 1.15A 4e0fA-1bk6A:
undetectable		 4e0fA-1bk6A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		5 SER A 424
VAL A 408
LEU A 365
ALA A 410
VAL A 389
 None
 1.25A 4e0fA-1cu1A:
0.0		 4e0fA-1cu1A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1few SECOND
MITOCHONDRIA-DERIVED
ACTIVATOR OF
CASPASES

(Homo sapiens) 		PF09057
(Smac_DIABLO) 		5 SER A  29
VAL A  23
GLU A 114
ALA A 116
THR A 119
 None
 1.19A 4e0fA-1fewA:
undetectable		 4e0fA-1fewA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g73 SECOND
MITOCHONDRIA-DERIVED
ACTIVATOR OF
CASPASES

(Homo sapiens) 		PF09057
(Smac_DIABLO) 		5 SER A  29
VAL A  23
THR A  30
ALA A 115
THR A 119
 None
 1.22A 4e0fA-1g73A:
undetectable		 4e0fA-1g73A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7g 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Escherichia
coli) 		PF02348
(CTP_transf_3) 		5 VAL A 142
THR A 139
GLU A 216
THR A 214
VAL A 144
 None
 1.21A 4e0fA-1h7gA:
0.0		 4e0fA-1h7gA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli) 		PF00923
(TAL_FSA) 		5 SER A 176
VAL A 172
LEU A 155
THR A 156
ALA A 143
 None
 1.04A 4e0fA-1i2oA:
0.0		 4e0fA-1i2oA:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i8d RIBOFLAVIN SYNTHASE

(Escherichia
coli) 		PF00677
(Lum_binding) 		5 LEU A 147
THR A 148
GLU A 164
THR A 169
VAL A   6
 None
 0.56A 4e0fA-1i8dA:
28.7		 4e0fA-1i8dA:
36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i8d RIBOFLAVIN SYNTHASE

(Escherichia
coli) 		PF00677
(Lum_binding) 		6 SER A  41
CYH A  48
LEU A  49
THR A  50
GLU A  66
THR A  71
 None
 0.66A 4e0fA-1i8dA:
28.7		 4e0fA-1i8dA:
36.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermotoga
maritima) 		PF00218
(IGPS) 		5 SER A 229
VAL A 203
LEU A 199
GLU A 187
ALA A 186
 None
 1.04A 4e0fA-1j5tA:
undetectable		 4e0fA-1j5tA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermotoga
maritima) 		PF00218
(IGPS) 		5 VAL A 203
LEU A 199
GLU A 187
ALA A 186
VAL A 184
 None
 1.09A 4e0fA-1j5tA:
undetectable		 4e0fA-1j5tA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr6 HELICASE NS3

(Hepacivirus C) 		PF00271
(Helicase_C) 		5 SER A  98
VAL A  82
LEU A  39
ALA A  84
VAL A  63
 None
 1.15A 4e0fA-1jr6A:
0.0		 4e0fA-1jr6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k94 GRANCALCIN

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13833
(EF-hand_8) 		5 SER A 136
VAL A 131
THR A 138
ALA A 147
HIS A 142
 CA  A 998 (-2.4A)
None
None
None
None
 1.25A 4e0fA-1k94A:
undetectable		 4e0fA-1k94A:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kzl RIBOFLAVIN SYNTHASE

(Schizosaccharomyces
pombe) 		PF00677
(Lum_binding) 		8 SER A  41
CYH A  48
LEU A  49
THR A  50
GLU A  66
THR A  71
HIS A 102
VAL A 103
 CRM  A 502 ( 4.0A)
HG  A1001 ( 2.5A)
CRM  A 502 (-4.4A)
CRM  A 502 (-3.9A)
None
None
CRM  A 502 (-4.2A)
CRM  A 502 (-4.0A)
 0.70A 4e0fA-1kzlA:
29.1		 4e0fA-1kzlA:
36.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 VAL A 789
THR A1070
ALA A 769
THR A 772
VAL A 764
 None
 1.18A 4e0fA-1n5xA:
0.0		 4e0fA-1n5xA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		5 SER A 239
VAL A 217
LEU A 241
GLU A 244
ALA A 245
 None
 1.19A 4e0fA-1oznA:
0.0		 4e0fA-1oznA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 THR B 232
TRP B 184
ALA B 148
THR B 155
VAL B 159
 None
 1.20A 4e0fA-1pjmB:
undetectable		 4e0fA-1pjmB:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1s 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Escherichia
coli) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 SER A   8
VAL A  96
LEU A   6
ALA A  88
VAL A  93
 None
 1.22A 4e0fA-1t1sA:
undetectable		 4e0fA-1t1sA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A 236
GLU A  52
ALA A  51
THR A  34
VAL A  49
 None
 1.03A 4e0fA-1tqyA:
undetectable		 4e0fA-1tqyA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 LEU A  57
THR A  56
ALA A 354
THR A  35
VAL A 365
 None
 0.96A 4e0fA-1ufaA:
undetectable		 4e0fA-1ufaA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		5 VAL A 189
LEU A 191
ALA A 211
THR A 215
VAL A 182
 None
 1.13A 4e0fA-1vefA:
undetectable		 4e0fA-1vefA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1

(Saccharomyces
cerevisiae) 		PF02463
(SMC_N) 		5 VAL A  49
LEU A  50
GLU A 106
ALA A  96
VAL A  94
 None
 1.13A 4e0fA-1w1wA:
undetectable		 4e0fA-1w1wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3k CYTOPLASMIC PROTEIN
NCK2

(Homo sapiens) 		PF00017
(SH2) 		5 SER A  39
VAL A   8
LEU A  27
ALA A  16
HIS A  11
 None
 1.19A 4e0fA-1z3kA:
undetectable		 4e0fA-1z3kA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bqx INORGANIC
PYROPHOSPHATASE

(Helicobacter
pylori) 		PF00719
(Pyrophosphatase) 		5 SER A   9
VAL A  17
CYH A  16
LEU A  15
ALA A 106
 None
 1.20A 4e0fA-2bqxA:
undetectable		 4e0fA-2bqxA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6w PENICILLIN-BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 SER B 389
VAL B 394
LEU B 421
THR B 390
ALA B 424
 None
 1.23A 4e0fA-2c6wB:
undetectable		 4e0fA-2c6wB:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 SER A  63
VAL A  75
ALA A  10
THR A  83
HIS A  73
 None
 1.19A 4e0fA-2e8yA:
2.4		 4e0fA-2e8yA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekj COLLAGEN ALPHA-1(XX)
CHAIN

(Homo sapiens) 		PF00041
(fn3) 		5 SER A  53
VAL A  56
LEU A  40
THR A  41
HIS A  37
 None
 1.17A 4e0fA-2ekjA:
0.9		 4e0fA-2ekjA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		5 SER A 265
LEU A 267
THR A 268
HIS A  16
VAL A  14
 None
 1.07A 4e0fA-2gt1A:
undetectable		 4e0fA-2gt1A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iml HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF04289
(DUF447) 		5 VAL A 136
LEU A 140
GLU A 182
ALA A 180
VAL A 169
 None
FMN  A 200 (-3.9A)
None
None
None
 1.11A 4e0fA-2imlA:
undetectable		 4e0fA-2imlA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k31 PHOSPHODIESTERASE
5A, CGMP-SPECIFIC

(Mus musculus) 		PF01590
(GAF) 		5 SER A 192
VAL A 180
LEU A 190
ALA A 224
VAL A 268
 None
 1.25A 4e0fA-2k31A:
undetectable		 4e0fA-2k31A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kig INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE II
ISOFORM

(Mus musculus) 		PF16776
(INPP5B_PH) 		5 SER A  38
VAL A  72
LEU A  40
ALA A  11
THR A  15
 None
 1.11A 4e0fA-2kigA:
undetectable		 4e0fA-2kigA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nps SYNTAXIN 13
VESICLE TRANSPORT
THROUGH INTERACTION
WITH T-SNARES
HOMOLOG 1A
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 4

(Mus musculus;
Rattus
norvegicus) 		PF00957
(Synaptobrevin)
PF05739
(SNARE)
PF12352
(V-SNARE_C) 		5 LEU A  92
GLU B 224
THR C 170
HIS B 229
VAL B 230
 None
 1.15A 4e0fA-2npsA:
undetectable		 4e0fA-2npsA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3i HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum) 		PF06032
(DUF917) 		5 VAL A 187
LEU A 191
GLU A 167
ALA A 156
VAL A 170
 None
 1.04A 4e0fA-2o3iA:
undetectable		 4e0fA-2o3iA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocd L-ASPARAGINASE I

(Vibrio cholerae) 		PF00710
(Asparaginase) 		5 VAL A 269
LEU A 271
THR A 272
GLU A 334
ALA A 306
 None
 1.16A 4e0fA-2ocdA:
undetectable		 4e0fA-2ocdA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogp PARTITIONING-DEFECTI
VE 3 HOMOLOG

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 SER A  96
VAL A  90
LEU A  94
THR A  97
GLU A  76
 None
 1.01A 4e0fA-2ogpA:
undetectable		 4e0fA-2ogpA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra8 UNCHARACTERIZED
PROTEIN Q64V53_BACFR

(Bacteroides
fragilis) 		PF05406
(WGR) 		5 VAL A   6
LEU A  32
GLU A  70
ALA A  73
THR A  68
 None
 1.11A 4e0fA-2ra8A:
undetectable		 4e0fA-2ra8A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		5 SER A 235
VAL A 231
THR A 236
HIS A 174
VAL A 173
 None
None
None
ZN  A1006 (-3.2A)
None
 1.03A 4e0fA-2z00A:
undetectable		 4e0fA-2z00A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		5 VAL A 438
LEU A 471
THR A 472
GLU A 445
VAL A 441
 None
 1.14A 4e0fA-2z6hA:
undetectable		 4e0fA-2z6hA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccq 50S RIBOSOMAL
PROTEIN L4P

(Haloarcula
marismortui) 		PF00573
(Ribosomal_L4) 		5 SER C 238
LEU C 240
THR C 236
GLU C  15
ALA C   3
 None
 1.13A 4e0fA-3ccqC:
undetectable		 4e0fA-3ccqC:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Burkholderia
pseudomallei) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 CYH A 232
LEU A 231
GLU A 270
ALA A 248
VAL A 246
 None
 1.24A 4e0fA-3dahA:
undetectable		 4e0fA-3dahA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		5 SER A  68
VAL A  65
LEU A 117
THR A 118
VAL A 114
 None
 1.13A 4e0fA-3e53A:
undetectable		 4e0fA-3e53A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5z PUTATIVE
GLUCONOLACTONASE

(Deinococcus
radiodurans) 		PF08450
(SGL) 		5 LEU A 242
THR A 243
TRP A 232
ALA A 233
THR A 220
 None
 1.18A 4e0fA-3e5zA:
undetectable		 4e0fA-3e5zA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezq PROTEIN FADD
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 6

(Homo sapiens) 		PF00531
(Death) 		5 VAL B 180
GLU B  95
ALA B  99
THR A 235
VAL A 239
 None
 0.95A 4e0fA-3ezqB:
undetectable		 4e0fA-3ezqB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		5 VAL 3 615
LEU 3 351
THR 3 350
GLU 3 545
ALA 3 546
 None
 1.22A 4e0fA-3i9v3:
undetectable		 4e0fA-3i9v3:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igx TRANSALDOLASE

(Francisella
tularensis) 		PF00923
(TAL_FSA) 		5 SER A 179
VAL A 175
LEU A 158
THR A 159
ALA A 146
 None
 1.03A 4e0fA-3igxA:
undetectable		 4e0fA-3igxA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iie 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Yersinia
pseudotuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 SER A   9
VAL A  97
LEU A   7
ALA A  89
VAL A  94
 None
 1.21A 4e0fA-3iieA:
undetectable		 4e0fA-3iieA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 C381 TURRET PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 5 SER P 361
VAL P 365
THR P 362
THR P 308
VAL P 311
 None
 1.10A 4e0fA-3j31P:
undetectable		 4e0fA-3j31P:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnp AMIDOHYDROLASE
FAMILY PROTEIN
OLEI01672_1_465

(Oleispira
antarctica) 		PF01979
(Amidohydro_1) 		5 SER A 141
THR A 143
GLU A 132
ALA A 163
THR A 443
 None
 1.06A 4e0fA-3lnpA:
undetectable		 4e0fA-3lnpA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		5 SER A 157
VAL A 194
LEU A 159
GLU A 182
ALA A 180
 None
 1.17A 4e0fA-3m8yA:
undetectable		 4e0fA-3m8yA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 VAL A 434
LEU A 435
ALA A 128
HIS A 449
VAL A 453
 None
IMD  A 513 ( 4.0A)
None
GOL  A 522 (-4.4A)
None
 1.18A 4e0fA-3pfeA:
undetectable		 4e0fA-3pfeA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q80 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01128
(IspD) 		5 SER A  48
VAL A  42
LEU A  46
ALA A  74
VAL A  12
 None
 1.21A 4e0fA-3q80A:
undetectable		 4e0fA-3q80A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv0 MITOCHONDRIAL ACIDIC
PROTEIN MAM33

(Saccharomyces
cerevisiae) 		PF02330
(MAM33) 		5 LEU A  88
GLU A  96
ALA A  97
HIS A 110
VAL A 111
 None
 1.03A 4e0fA-3qv0A:
undetectable		 4e0fA-3qv0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 VAL C 789
THR C1070
ALA C 769
THR C 772
VAL C 764
 None
 1.15A 4e0fA-3sr6C:
undetectable		 4e0fA-3sr6C:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w79 FMN-DEPENDENT
NADH-AZOREDUCTASE

(Bacillus sp.
B29) 		PF02525
(Flavodoxin_2) 		5 VAL A 175
LEU A 170
THR A 168
GLU A 179
ALA A 141
 None
 1.24A 4e0fA-3w79A:
undetectable		 4e0fA-3w79A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyd LC-EST1C

(uncultured
organism) 		PF00326
(Peptidase_S9) 		5 VAL A 422
ALA A 483
THR A 486
HIS A 443
VAL A 442
 None
 1.22A 4e0fA-3wydA:
undetectable		 4e0fA-3wydA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkb DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 VAL A  54
LEU A 204
THR A 205
GLU A 196
THR A 307
 None
 1.22A 4e0fA-3zkbA:
undetectable		 4e0fA-3zkbA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		5 SER A 733
VAL A 728
LEU A 731
GLU A 693
ALA A 691
 None
 1.24A 4e0fA-4b8bA:
undetectable		 4e0fA-4b8bA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)

(Clostridioides
difficile) 		PF00112
(Peptidase_C1) 		5 SER A 443
VAL A 430
LEU A 445
THR A 444
VAL A 383
 None
 1.16A 4e0fA-4ci7A:
undetectable		 4e0fA-4ci7A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)

(Clostridioides
difficile) 		PF00112
(Peptidase_C1) 		5 SER A 443
VAL A 430
LEU A 445
THR A 444
VAL A 383
 None
 1.15A 4e0fA-4d59A:
undetectable		 4e0fA-4d59A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em7 DNA TOPOISOMERASE
IV, B SUBUNIT

(Streptococcus
pneumoniae) 		PF02518
(HATPase_c) 		5 SER A 210
VAL A 207
GLU A  55
ALA A  56
HIS A  79
 None
None
0RA  A 301 (-3.4A)
None
None
 1.09A 4e0fA-4em7A:
0.4		 4e0fA-4em7A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em7 DNA TOPOISOMERASE
IV, B SUBUNIT

(Streptococcus
pneumoniae) 		PF02518
(HATPase_c) 		5 SER A 210
VAL A 207
LEU A 209
GLU A  55
HIS A  79
 None
None
None
0RA  A 301 (-3.4A)
None
 0.97A 4e0fA-4em7A:
0.4		 4e0fA-4em7A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4w DNA POLYMERASE IV

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		5 VAL A 336
GLU A 315
ALA A 312
HIS A 286
VAL A 287
 None
 1.22A 4e0fA-4f4wA:
undetectable		 4e0fA-4f4wA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3t OXIDOREDUCTASE DPRE1

(Mycolicibacterium
smegmatis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		5 LEU A 168
THR A 169
TRP A 179
THR A 188
VAL A 451
 None
 1.23A 4e0fA-4g3tA:
undetectable		 4e0fA-4g3tA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm6 PFKB FAMILY
CARBOHYDRATE KINASE

(Listeria grayi) 		PF00294
(PfkB) 		5 SER A 109
VAL A  56
LEU A  86
ALA A  65
VAL A  79
 None
 1.14A 4e0fA-4gm6A:
undetectable		 4e0fA-4gm6A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 SER A 384
VAL A 317
LEU A 360
TRP A 361
ALA A 353
 None
 1.23A 4e0fA-4h53A:
undetectable		 4e0fA-4h53A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2h INTRACELLULAR
PROTEASE/AMIDASE

(Salmonella
enterica) 		PF01965
(DJ-1_PfpI) 		5 VAL A   6
LEU A   8
GLU A  16
ALA A  17
VAL A  68
 None
 1.15A 4e0fA-4k2hA:
undetectable		 4e0fA-4k2hA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw5 OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		5 LEU A 161
THR A 162
TRP A 172
THR A 181
VAL A 444
 None
 1.23A 4e0fA-4kw5A:
undetectable		 4e0fA-4kw5A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY

(Yersinia
frederiksenii) 		PF01758
(SBF) 		5 SER A  59
GLU A 254
ALA A  67
THR A  68
VAL A 128
 None
 1.19A 4e0fA-4n7wA:
undetectable		 4e0fA-4n7wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4piv FATTY ACID SYNTHASE

(Homo sapiens) 		PF08242
(Methyltransf_12)
PF08659
(KR) 		5 SER A1942
VAL A1939
LEU A1914
THR A1915
ALA A1901
 None
None
None
NDP  A2202 (-4.5A)
None
 1.16A 4e0fA-4pivA:
undetectable		 4e0fA-4pivA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl3 CHITINASE A

(Pteris
ryukyuensis) 		PF00704
(Glyco_hydro_18) 		5 SER A 362
LEU A 365
THR A 364
ALA A 338
VAL A 352
 None
 1.13A 4e0fA-4rl3A:
undetectable		 4e0fA-4rl3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxp NS3-4 PROTEASE

(Hepacivirus C) 		PF07652
(Flavi_DEAD) 		5 SER A 424
VAL A 408
LEU A 365
ALA A 410
VAL A 389
 None
 1.16A 4e0fA-4wxpA:
undetectable		 4e0fA-4wxpA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Actinomyces
urogenitalis) 		PF00977
(His_biosynth) 		5 SER A 216
VAL A 219
LEU A   4
THR A   3
HIS A  48
 None
PO4  A 301 ( 4.7A)
None
None
PO4  A 303 (-4.1A)
 1.11A 4e0fA-4x2rA:
undetectable		 4e0fA-4x2rA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
vulgaris) 		PF03480
(DctP) 		5 VAL A  44
THR A  41
GLU A  57
ALA A  56
HIS A  77
 None
 1.25A 4e0fA-4xeqA:
undetectable		 4e0fA-4xeqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yr1 ALKALINE PHOSPHATASE

(Escherichia
coli) 		PF00245
(Alk_phosphatase) 		5 VAL A 321
LEU A  48
GLU A 347
ALA A 348
THR A 303
 None
 1.21A 4e0fA-4yr1A:
undetectable		 4e0fA-4yr1A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 VAL A 461
LEU A 395
ALA A 463
THR A 503
VAL A 501
 None
 1.13A 4e0fA-4zo6A:
undetectable		 4e0fA-4zo6A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 SER A1706
VAL A1133
ALA A1276
THR A1280
HIS A1294
 None
None
None
None
ZN  A3001 (-3.1A)
 1.14A 4e0fA-5a22A:
undetectable		 4e0fA-5a22A:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 VAL A 291
THR A 270
GLU A 281
ALA A 283
HIS A 295
 None
 1.16A 4e0fA-5b25A:
undetectable		 4e0fA-5b25A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Streptomyces
halstedii) 		no annotation 5 SER A 266
VAL A 259
LEU A 263
ALA A 113
VAL A 244
 None
 1.14A 4e0fA-5czcA:
undetectable		 4e0fA-5czcA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		5 VAL A 144
LEU A  89
THR A  88
ALA A  95
THR A  98
 None
 1.19A 4e0fA-5djqA:
undetectable		 4e0fA-5djqA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		5 LEU A 554
THR A 555
GLU A 608
ALA A 609
HIS A 475
 None
 1.20A 4e0fA-5f7uA:
1.5		 4e0fA-5f7uA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f89 CAP248-2B LIGHT
CHAIN

(Homo sapiens) 		no annotation 5 SER L 100
VAL L  97
LEU L   4
THR L   5
THR L  92
 None
 1.24A 4e0fA-5f89L:
undetectable		 4e0fA-5f89L:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9q MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN YKNZ

(Bacillus
amyloliquefaciens) 		PF12704
(MacB_PCD) 		5 VAL A 181
LEU A  20
GLU A 195
ALA A 196
VAL A  55
 None
 1.25A 4e0fA-5f9qA:
1.2		 4e0fA-5f9qA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1

(Caenorhabditis
elegans;
Homo sapiens) 		PF00090
(TSP_1)
PF10250
(O-FucT) 		5 VAL A  64
LEU A 197
THR A 196
GLU A 218
ALA A 217
 None
 1.25A 4e0fA-5foeA:
undetectable		 4e0fA-5foeA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN

(Escherichia
coli) 		PF00466
(Ribosomal_L10) 		5 LEU i   9
THR i   6
GLU i  40
ALA i  37
VAL i  43
 None
 1.21A 4e0fA-5gafi:
undetectable		 4e0fA-5gafi:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx9 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		5 VAL A 225
THR A 219
ALA A 281
THR A 285
VAL A 249
 None
 1.24A 4e0fA-5hx9A:
undetectable		 4e0fA-5hx9A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 SER A1667
VAL A1787
LEU A1767
GLU A1790
ALA A1833
 None
 1.03A 4e0fA-5i6gA:
undetectable		 4e0fA-5i6gA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 SER A1667
VAL A1787
LEU A1767
GLU A1790
ALA A1833
 None
 1.06A 4e0fA-5i6hA:
undetectable		 4e0fA-5i6hA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 SER A1667
VAL A1787
LEU A1767
GLU A1790
ALA A1833
 None
 0.98A 4e0fA-5i6iA:
undetectable		 4e0fA-5i6iA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9h ENVELOPMENT
POLYPROTEIN

(Puumala
orthohantavirus) 		PF01561
(Hanta_G2) 		5 LEU A 856
THR A 855
GLU A 725
ALA A 724
HIS A 728
 None
 1.20A 4e0fA-5j9hA:
undetectable		 4e0fA-5j9hA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgg ALPHA CHAIN

(Acipenser
persicus) 		PF00042
(Globin) 		5 SER A  85
VAL A 133
LEU A  81
THR A  82
HIS A 135
 None
 1.04A 4e0fA-5jggA:
undetectable		 4e0fA-5jggA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 VAL A 301
THR A  38
GLU A 338
HIS A 297
VAL A 298
 None
 1.17A 4e0fA-5kufA:
undetectable		 4e0fA-5kufA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 VAL A 773
CYH A 774
LEU A 775
THR A 776
GLU A 824
 None
 1.20A 4e0fA-5l46A:
1.5		 4e0fA-5l46A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 5 VAL A  87
LEU A 110
GLU A  84
ALA A  51
THR A  53
 None
 1.22A 4e0fA-5oynA:
undetectable		 4e0fA-5oynA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy4 CHAPERONE YAJL

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		5 VAL A   7
LEU A   9
GLU A  17
ALA A  18
VAL A  71
 None
 1.24A 4e0fA-5sy4A:
undetectable		 4e0fA-5sy4A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvk C-PHYCOCYANIN ALPHA
CHAIN

(Thermosynechococcus
elongatus) 		PF00502
(Phycobilisome) 		5 VAL A  95
LEU A  44
THR A  45
GLU A 149
ALA A 150
 None
 1.25A 4e0fA-5uvkA:
undetectable		 4e0fA-5uvkA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1j THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Echinococcus
granulosus) 		no annotation 5 VAL A 292
CYH A 291
LEU A 290
THR A 289
VAL A 391
 None
 0.98A 4e0fA-5w1jA:
undetectable		 4e0fA-5w1jA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 5 SER A 424
VAL A 408
LEU A 365
ALA A 410
VAL A 389
 None
 1.13A 4e0fA-5wdxA:
undetectable		 4e0fA-5wdxA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 5 VAL A  56
LEU A  54
THR A  53
GLU A  40
ALA A  38
 None
 1.23A 4e0fA-6cipA:
undetectable		 4e0fA-6cipA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft -

(-) 		no annotation 5 SER B 291
VAL B 280
ALA B 317
HIS B 314
VAL B 313
 NAD  A 502 ( 3.1A)
None
NAD  B 500 (-3.6A)
None
None
 1.07A 4e0fA-6dftB:
undetectable		 4e0fA-6dftB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0a ASPARTYL TRNA
SYNTHETASE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 LYS A 167
THR A 169
ILE A 505
 None
A  B 676 ( 3.6A)
None
 0.58A 4e0fB-1c0aA:
2.0		 4e0fB-1c0aA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgf CATALASE

(Homo sapiens) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 LYS A  77
THR A 115
ILE A 205
 None
 0.72A 4e0fB-1dgfA:
0.0		 4e0fB-1dgfA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dzb SCFV FRAGMENT 1F9

(Mus musculus) 		PF07686
(V-set) 		3 LYS A 239
THR A 284
ILE A 275
 None
 0.78A 4e0fB-1dzbA:
1.0		 4e0fB-1dzbA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1c HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		3 LYS A 202
THR A 199
ILE A  88
 PLP  A1202 (-1.3A)
PLP  A1202 (-3.3A)
None
 0.84A 4e0fB-1h1cA:
0.6		 4e0fB-1h1cA:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i8d RIBOFLAVIN SYNTHASE

(Escherichia
coli) 		PF00677
(Lum_binding) 		3 LYS A 137
THR A 148
ILE A 162
 None
 0.34A 4e0fB-1i8dA:
29.8		 4e0fB-1i8dA:
36.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jik TYROSYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00579
(tRNA-synt_1b) 		3 LYS A 305
THR A 304
ILE A 257
 None
 0.92A 4e0fB-1jikA:
0.0		 4e0fB-1jikA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzu LIPOCALIN Q83

(Coturnix
coturnix) 		PF00061
(Lipocalin) 		3 LYS A  93
THR A  90
ILE A 128
 None
 0.88A 4e0fB-1jzuA:
undetectable		 4e0fB-1jzuA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kej TERMINAL
DEOXYNUCLEOTIDYLTRAN
SFERASE SHORT
ISOFORM

(Mus musculus) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		3 LYS A 199
THR A 169
ILE A 174
 None
 0.89A 4e0fB-1kejA:
0.0		 4e0fB-1kejA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgd PERIPHERAL PLASMA
MEMBRANE CASK

(Homo sapiens) 		PF00625
(Guanylate_kin) 		3 LYS A 757
THR A 753
ILE A 894
 None
 0.94A 4e0fB-1kgdA:
0.0		 4e0fB-1kgdA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lsh LIPOVITELLIN (LV-1N,
LV-1C)

(Ichthyomyzon
unicuspis) 		PF01347
(Vitellogenin_N)
PF09172
(DUF1943) 		3 LYS A 881
THR A 876
ILE A 288
 None
 0.93A 4e0fB-1lshA:
undetectable		 4e0fB-1lshA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mfw DOUBLECORTIN-LIKE
KINASE (N-TERMINAL
DOMAIN)

(Homo sapiens) 		PF03607
(DCX) 		3 LYS A 116
THR A 107
ILE A 134
 SO4  A1002 (-3.5A)
None
SO4  A1001 (-4.3A)
 0.84A 4e0fB-1mfwA:
undetectable		 4e0fB-1mfwA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		3 LYS A 379
THR A 380
ILE A 422
 None
 0.93A 4e0fB-1mhsA:
undetectable		 4e0fB-1mhsA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 LYS A 616
THR A 695
ILE A 752
 None
 0.91A 4e0fB-1n7rA:
undetectable		 4e0fB-1n7rA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg5 ORF, HYPOTHETICAL
PROTEIN

(Escherichia
coli) 		PF07073
(ROF) 		3 LYS A  37
THR A  29
ILE A  78
 None
 0.93A 4e0fB-1sg5A:
undetectable		 4e0fB-1sg5A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 LYS A  56
THR A  94
ILE A 184
 None
 0.71A 4e0fB-1si8A:
undetectable		 4e0fB-1si8A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		3 LYS A  78
THR A  82
ILE A 104
 None
 0.85A 4e0fB-1xfuA:
undetectable		 4e0fB-1xfuA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii) 		PF01266
(DAO) 		3 LYS B 145
THR B  49
ILE B 229
 None
None
FMN  A 802 ( 4.1A)
 0.90A 4e0fB-1y56B:
undetectable		 4e0fB-1y56B:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx7 DIHYDROOROTATE
DEHYDROGENASE

(Lactococcus
lactis) 		PF01180
(DHO_dh) 		3 LYS A 276
THR A 272
ILE A 224
 None
FMN  A1312 (-3.7A)
FMN  A1312 ( 4.9A)
 0.88A 4e0fB-2bx7A:
undetectable		 4e0fB-2bx7A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cai GLUTATHIONE
S-TRANSFERASE 28 KDA

(Schistosoma
haematobium) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 LYS A 175
THR A 171
ILE A 164
 None
 0.87A 4e0fB-2caiA:
undetectable		 4e0fB-2caiA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cr9 POLY [ADP-RIBOSE]
POLYMERASE-1

(Homo sapiens) 		PF05406
(WGR) 		3 LYS A  54
THR A  56
ILE A  86
 None
 0.90A 4e0fB-2cr9A:
undetectable		 4e0fB-2cr9A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE

(Oryza sativa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 LYS A 146
THR A 151
ILE A 164
 CSO  A 145 ( 3.6A)
None
None
 0.79A 4e0fB-2cvoA:
undetectable		 4e0fB-2cvoA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dt8 DEGV FAMILY PROTEIN

(Thermus
thermophilus) 		PF02645
(DegV) 		3 LYS A 191
THR A 189
ILE A 211
 GOL  A 601 (-2.9A)
GOL  A 601 (-4.0A)
None
 0.88A 4e0fB-2dt8A:
undetectable		 4e0fB-2dt8A:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5o ACTIVATING SIGNAL
COINTEGRATOR 1

(Homo sapiens) 		PF04266
(ASCH) 		3 LYS A  47
THR A  45
ILE A  42
 None
 0.93A 4e0fB-2e5oA:
undetectable		 4e0fB-2e5oA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		3 LYS A 133
THR A 136
ILE A 161
 None
 0.83A 4e0fB-2gv8A:
undetectable		 4e0fB-2gv8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqf CATALASE

(Helicobacter
pylori) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 LYS A  58
THR A  96
ILE A 186
 None
 0.82A 4e0fB-2iqfA:
undetectable		 4e0fB-2iqfA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isa CATALASE

(Aliivibrio
salmonicida) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 LYS A  56
THR A  94
ILE A 184
 None
 0.76A 4e0fB-2isaA:
undetectable		 4e0fB-2isaA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph5 HOMOSPERMIDINE
SYNTHASE

(Legionella
pneumophila) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 LYS A 306
THR A 304
ILE A 297
 None
 0.82A 4e0fB-2ph5A:
undetectable		 4e0fB-2ph5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk9 PHO85 CYCLIN PHO80

(Saccharomyces
cerevisiae) 		PF08613
(Cyclin) 		3 LYS B  86
THR B  85
ILE B  39
 None
 0.90A 4e0fB-2pk9B:
undetectable		 4e0fB-2pk9B:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prv UNCHARACTERIZED
PROTEIN YOBK

(Bacillus
subtilis) 		PF14567
(SUKH_5) 		3 LYS A  78
THR A  74
ILE A  31
 EDO  A 159 (-3.4A)
None
None
 0.82A 4e0fB-2prvA:
undetectable		 4e0fB-2prvA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puq TISSUE FACTOR

(Homo sapiens) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		3 LYS T  28
THR T  55
ILE T  22
 None
 0.88A 4e0fB-2puqT:
undetectable		 4e0fB-2puqT:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA

(Mus musculus;
Paraburkholderia
xenovorans) 		PF01007
(IRK) 		3 LYS A  11
THR A 261
ILE A 217
 None
 0.90A 4e0fB-2qksA:
0.6		 4e0fB-2qksA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0s LR1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		3 LYS A 201
THR A 192
ILE A 221
 None
 0.91A 4e0fB-2v0sA:
undetectable		 4e0fB-2v0sA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus) 		PF00294
(PfkB) 		3 LYS A 175
THR A 179
ILE A 150
 None
 0.77A 4e0fB-2varA:
undetectable		 4e0fB-2varA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8k HYPOTHETICAL PROTEIN
19.1

(Bacillus phage
SPP1) 		PF05709
(Sipho_tail) 		3 LYS A 251
THR A 249
ILE A 203
 None
 0.82A 4e0fB-2x8kA:
1.9		 4e0fB-2x8kA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 LYS A 716
THR A 720
ILE A 590
 None
 0.68A 4e0fB-2xaxA:
undetectable		 4e0fB-2xaxA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0e UDP-GLUCOSE
DEHYDROGENASE

(Burkholderia
cepacia) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		3 LYS A 331
THR A 334
ILE A  46
 UGA  A 501 (-2.7A)
None
None
 0.91A 4e0fB-2y0eA:
undetectable		 4e0fB-2y0eA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8c DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Plasmodium
falciparum) 		PF00692
(dUTPase) 		3 LYS A  96
THR A  97
ILE A 130
 None
 0.76A 4e0fB-2y8cA:
undetectable		 4e0fB-2y8cA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio) 		PF00514
(Arm) 		3 LYS A 334
THR A 338
ILE A 302
 None
 0.85A 4e0fB-2z6gA:
undetectable		 4e0fB-2z6gA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a74 LYSYL-TRNA
SYNTHETASE

(Geobacillus
stearothermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 LYS A  36
THR A  83
ILE A 175
 None
 0.79A 4e0fB-3a74A:
undetectable		 4e0fB-3a74A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9v 4-COUMARATE--COA
LIGASE

(Populus
tomentosa) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LYS A 394
THR A 199
ILE A 175
 None
 0.86A 4e0fB-3a9vA:
undetectable		 4e0fB-3a9vA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akz GLUTAMYL-TRNA
SYNTHETASE 2

(Thermotoga
maritima) 		no annotation 3 LYS B 455
THR B 458
ILE B 365
 None
U  F  35 ( 4.9A)
None
 0.79A 4e0fB-3akzB:
undetectable		 4e0fB-3akzB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq1 THERMOSOME SUBUNIT

(Methanococcoides
burtonii) 		PF00118
(Cpn60_TCP1) 		3 LYS B 395
THR B 131
ILE B 126
 None
 0.86A 4e0fB-3aq1B:
undetectable		 4e0fB-3aq1B:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5n PROTEIN TRANSPORT
PROTEIN SEC9
SYNAPTOBREVIN
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00957
(Synaptobrevin)
no annotation 		3 LYS A  26
THR A  29
ILE D 594
 None
 0.91A 4e0fB-3b5nA:
undetectable		 4e0fB-3b5nA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9g UPF0200/UPF0201
PROTEIN AF_1395

(Archaeoglobus
fulgidus) 		PF01877
(RNA_binding) 		3 LYS A 287
THR A 195
ILE A 221
 None
 0.89A 4e0fB-3c9gA:
undetectable		 4e0fB-3c9gA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cux MALATE SYNTHASE

(Bacillus
anthracis) 		PF01274
(Malate_synthase) 		3 LYS A 311
THR A 315
ILE A  70
 None
 0.88A 4e0fB-3cuxA:
undetectable		 4e0fB-3cuxA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyk HEMAGGLUTININ HA1
CHAIN
HEMAGGLUTININ HA2
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 LYS A  40
THR A 322
ILE B  45
 None
 0.90A 4e0fB-3eykA:
undetectable		 4e0fB-3eykA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3o VACUOLAR TRANSPORTER
CHAPERONE 2

(Saccharomyces
cerevisiae) 		PF09359
(VTC) 		3 LYS A 275
THR A 405
ILE A 421
 None
 0.81A 4e0fB-3g3oA:
undetectable		 4e0fB-3g3oA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grp 3-OXOACYL-(ACYL
CARRIERPROTEIN)
REDUCTASE

(Bartonella
henselae) 		PF13561
(adh_short_C2) 		3 LYS A 156
THR A 138
ILE A 216
 None
 0.80A 4e0fB-3grpA:
undetectable		 4e0fB-3grpA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvz UNCHARACTERIZED
PROTEIN CV2077

(Chromobacterium
violaceum) 		PF03417
(AAT) 		3 LYS A  26
THR A 174
ILE A 189
 None
 0.91A 4e0fB-3gvzA:
undetectable		 4e0fB-3gvzA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1

(Schizosaccharomyces
pombe) 		PF00498
(FHA) 		3 LYS A 171
THR A 173
ILE A 118
 None
 0.85A 4e0fB-3i0mA:
undetectable		 4e0fB-3i0mA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53

(Homo sapiens) 		PF00270
(DEAD) 		3 LYS A 281
THR A 282
ILE A 359
 None
AMP  A 160 (-3.5A)
None
 0.93A 4e0fB-3iuyA:
undetectable		 4e0fB-3iuyA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7v PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1377C

(Streptococcus
mutans) 		PF01300
(Sua5_yciO_yrdC) 		3 LYS A   0
THR A   2
ILE A  18
 None
 0.82A 4e0fB-3l7vA:
undetectable		 4e0fB-3l7vA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnb N-ACETYLTRANSFERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00797
(Acetyltransf_2) 		3 LYS A 246
THR A 239
ILE A 221
 COA  A1001 (-2.6A)
COA  A1001 (-3.9A)
COA  A1001 ( 3.8A)
 0.81A 4e0fB-3lnbA:
undetectable		 4e0fB-3lnbA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m51 14-3-3-LIKE PROTEIN
C

(Nicotiana
tabacum) 		PF00244
(14-3-3) 		3 LYS A 220
THR A 224
ILE A 209
 None
 0.69A 4e0fB-3m51A:
undetectable		 4e0fB-3m51A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msu CITRATE SYNTHASE

(Francisella
tularensis) 		PF00285
(Citrate_synt) 		3 LYS A 219
THR A 223
ILE A  79
 None
 0.85A 4e0fB-3msuA:
undetectable		 4e0fB-3msuA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		3 LYS A 330
THR A 333
ILE A 309
 None
 0.77A 4e0fB-3nawA:
undetectable		 4e0fB-3nawA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oe7 ATP SYNTHASE SUBUNIT
GAMMA

(Saccharomyces
cerevisiae) 		PF00231
(ATP-synt) 		3 LYS G   1
THR G 258
ILE G 253
 None
 0.90A 4e0fB-3oe7G:
undetectable		 4e0fB-3oe7G:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oos ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		3 LYS A 215
THR A 109
ILE A  77
 None
 0.82A 4e0fB-3oosA:
undetectable		 4e0fB-3oosA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		3 LYS A 383
THR A 382
ILE A 351
 None
 0.92A 4e0fB-3psiA:
undetectable		 4e0fB-3psiA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LYS A 429
THR A 171
ILE A 229
 None
 0.73A 4e0fB-3qtpA:
undetectable		 4e0fB-3qtpA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr6 O-METHYLTRANSFERASE

(Coxiella
burnetii) 		PF01596
(Methyltransf_3) 		3 LYS A 147
THR A 150
ILE A 167
 NI  A 223 ( 4.1A)
None
None
 0.88A 4e0fB-3tr6A:
undetectable		 4e0fB-3tr6A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		3 LYS A1400
THR A1383
ILE A1514
 None
 0.92A 4e0fB-4a5wA:
2.2		 4e0fB-4a5wA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3

(Homo sapiens) 		PF01299
(Lamp) 		3 LYS A 278
THR A 293
ILE A 322
 NAG  A1379 ( 4.5A)
NAG  A1379 (-2.7A)
None
 0.92A 4e0fB-4akmA:
undetectable		 4e0fB-4akmA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq4 SN-GLYCEROL-3-PHOSPH
ATE-BINDING
PERIPLASMIC PROTEIN
UGPB

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		3 LYS A 293
THR A 297
ILE A  34
 None
 0.91A 4e0fB-4aq4A:
undetectable		 4e0fB-4aq4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		3 LYS A1050
THR A 955
ILE A 962
 None
 0.83A 4e0fB-4bfrA:
undetectable		 4e0fB-4bfrA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		3 LYS A 152
THR A 201
ILE A 107
 None
 0.79A 4e0fB-4c30A:
undetectable		 4e0fB-4c30A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx0 14-3-3-LIKE PROTEIN
E

(Nicotiana
tabacum) 		PF00244
(14-3-3) 		3 LYS A 218
THR A 222
ILE A 207
 None
 0.64A 4e0fB-4dx0A:
undetectable		 4e0fB-4dx0A:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep0 MAJOR TAIL PROTEIN

(Streptococcus
virus C1) 		PF16838
(Caud_tail_N) 		3 LYS A 343
THR A 339
ILE A 364
 None
 0.84A 4e0fB-4ep0A:
0.2		 4e0fB-4ep0A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 3 LYS A 313
THR A 318
ILE A 323
 CL  A 502 ( 3.9A)
None
None
 0.86A 4e0fB-4eziA:
undetectable		 4e0fB-4eziA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kp2 HOMOACONITASE LARGE
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		3 LYS A 217
THR A 131
ILE A 141
 None
 0.49A 4e0fB-4kp2A:
undetectable		 4e0fB-4kp2A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		3 LYS A1464
THR A1145
ILE A1140
 None
 0.93A 4e0fB-4ll8A:
undetectable		 4e0fB-4ll8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE

(Acinetobacter
baumannii) 		PF00348
(polyprenyl_synt) 		3 LYS A 238
THR A 240
ILE A 216
 None
 0.85A 4e0fB-4lobA:
undetectable		 4e0fB-4lobA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN

(Helicobacter
pylori) 		PF01497
(Peripla_BP_2) 		3 LYS A 172
THR A 176
ILE A 310
 None
 0.79A 4e0fB-4ls3A:
undetectable		 4e0fB-4ls3A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		3 LYS A 566
THR A 522
ILE A 539
 None
 0.91A 4e0fB-4madA:
2.0		 4e0fB-4madA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Thermosynechococcus
elongatus) 		PF06745
(ATPase) 		3 LYS A 404
THR A 400
ILE A 430
 None
None
SEP  A 431 ( 3.7A)
 0.88A 4e0fB-4o0mA:
undetectable		 4e0fB-4o0mA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7k ABC TRANSPORTER

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		3 LYS A 527
THR A 530
ILE A 508
 None
 0.77A 4e0fB-4q7kA:
undetectable		 4e0fB-4q7kA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		3 LYS A 409
THR A 639
ILE A 634
 AMP  A 777 (-2.9A)
None
None
 0.77A 4e0fB-4v1uA:
undetectable		 4e0fB-4v1uA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620) 		no annotation 3 LYS A 599
THR A 571
ILE A 514
 None
 0.80A 4e0fB-4xn3A:
3.1		 4e0fB-4xn3A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxz LEVOGLUCOSAN KINASE

(Lipomyces
starkeyi) 		PF03702
(AnmK) 		3 LYS A 361
THR A 365
ILE A 379
 None
 0.93A 4e0fB-4zxzA:
undetectable		 4e0fB-4zxzA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus) 		PF01398
(JAB) 		3 LYS H 156
THR H 157
ILE H 330
 None
 0.93A 4e0fB-5a5tH:
undetectable		 4e0fB-5a5tH:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LYS A 396
THR A 202
ILE A 178
 None
 0.91A 4e0fB-5bswA:
undetectable		 4e0fB-5bswA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE

(Geobacillus
stearothermophilus) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		3 LYS A 121
THR A 125
ILE A  10
 None
 0.85A 4e0fB-5c3mA:
undetectable		 4e0fB-5c3mA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d79 BERBERINE BRIDGE
ENZYME-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 LYS A 257
THR A 303
ILE A 173
 None
 0.89A 4e0fB-5d79A:
undetectable		 4e0fB-5d79A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6n PROTEIN LGG-2

(Caenorhabditis
elegans) 		PF02991
(Atg8) 		3 LYS A 101
THR A  69
ILE A  76
 None
 0.92A 4e0fB-5e6nA:
undetectable		 4e0fB-5e6nA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN

(Streptococcus
suis) 		PF05833
(FbpA) 		3 LYS A 134
THR A 117
ILE A  91
 None
 0.87A 4e0fB-5h3xA:
undetectable		 4e0fB-5h3xA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC

(Escherichia
coli) 		PF09344
(Cas_CT1975) 		3 LYS D 354
THR D 252
ILE D  58
 None
 0.94A 4e0fB-5h9fD:
undetectable		 4e0fB-5h9fD:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 LYS A 592
THR A 589
ILE A 186
 None
 0.91A 4e0fB-5ihrA:
undetectable		 4e0fB-5ihrA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz1 FRUCTOSE-1,6-BISPHOS
PHATASE

(Physcomitrella
patens) 		PF00316
(FBPase) 		3 LYS A  98
THR A  94
ILE A  89
 None
 0.89A 4e0fB-5iz1A:
undetectable		 4e0fB-5iz1A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 LYS A 427
THR A 933
ILE A 898
 None
 0.85A 4e0fB-5j6sA:
1.3		 4e0fB-5j6sA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		3 LYS A 514
THR A 512
ILE A 498
 None
 0.94A 4e0fB-5jcfA:
undetectable		 4e0fB-5jcfA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		3 LYS A 747
THR A 751
ILE A 320
 None
 0.92A 4e0fB-5jjrA:
undetectable		 4e0fB-5jjrA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9q HEMAGGLUTININ HA2

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 LYS B 121
THR B 122
ILE B 149
 None
 0.92A 4e0fB-5k9qB:
undetectable		 4e0fB-5k9qB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		3 LYS A 330
THR A 331
ILE A 374
 ACP  A 904 ( 4.8A)
ACP  A 904 (-3.4A)
ACP  A 904 (-4.3A)
 0.91A 4e0fB-5ksdA:
undetectable		 4e0fB-5ksdA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR A

(Homo sapiens) 		no annotation 3 LYS A   6
THR A   9
ILE A  38
 None
 0.92A 4e0fB-5l3xA:
undetectable		 4e0fB-5l3xA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldd RAB SMALL MONOMERIC
GTPASE-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00071
(Ras) 		3 LYS C 161
THR C 156
ILE C 127
 None
 0.81A 4e0fB-5lddC:
undetectable		 4e0fB-5lddC:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 3 LYS A  86
THR A  78
ILE A 278
 None
 0.77A 4e0fB-5opqA:
undetectable		 4e0fB-5opqA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 3 LYS A 752
THR A 754
ILE A 833
 None
 0.91A 4e0fB-5vhaA:
undetectable		 4e0fB-5vhaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW

(Bacillus
subtilis) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2) 		3 LYS A  68
THR A  71
ILE A 158
 None
 0.92A 4e0fB-5wuqA:
undetectable		 4e0fB-5wuqA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xr6 RAS-RELATED PROTEIN
RABA1A

(Arabidopsis
thaliana) 		no annotation 3 LYS A  76
THR A  79
ILE A  19
 None
 0.88A 4e0fB-5xr6A:
undetectable		 4e0fB-5xr6A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h25 -

(-) 		no annotation 3 LYS A  21
THR A  29
ILE A 253
 None
 0.76A 4e0fB-6h25A:
undetectable		 4e0fB-6h25A:
undetectable