SIMILAR PATTERNS OF AMINO ACIDS FOR 4DXU_A_ACAA711_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		6 GLY A 432
VAL A 591
PRO A 593
GLY A 662
GLU A 664
TYR A 665
 None
 0.74A 4dxuA-1biyA:
55.1		 4dxuA-1biyA:
91.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 260
VAL A 256
PRO A 258
GLY A 282
GLU A 280
 None
 1.16A 4dxuA-1bxzA:
undetectable		 4dxuA-1bxzA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhe GLUTATHIONE
TRANSFERASE

(Fasciola
hepatica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 GLY A  33
GLY A   5
GLU A  29
TYR A   6
 None
 0.79A 4dxuA-1fheA:
undetectable		 4dxuA-1fheA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fui L-FUCOSE ISOMERASE

(Escherichia
coli) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 GLY A 478
PRO A 506
GLY A 386
GLU A 384
 None
 0.84A 4dxuA-1fuiA:
undetectable		 4dxuA-1fuiA:
19.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h76 SEROTRANSFERRIN

(Sus scrofa) 		PF00405
(Transferrin) 		4 GLY A 430
PRO A 592
GLY A 660
TYR A 663
 None
 0.50A 4dxuA-1h76A:
43.6		 4dxuA-1h76A:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		4 GLY A 432
PRO A 593
GLY A 662
TYR A 665
 None
 0.58A 4dxuA-1i6qA:
27.4		 4dxuA-1i6qA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		4 GLY A 432
VAL A 591
PRO A 593
TYR A 665
 None
 0.88A 4dxuA-1i6qA:
27.4		 4dxuA-1i6qA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iq7 OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		4 GLY A 469
VAL A 664
GLY A 397
TYR A 400
 None
 0.58A 4dxuA-1iq7A:
36.6		 4dxuA-1iq7A:
51.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		4 GLY A 424
PRO A 580
GLY A 649
TYR A 652
 None
 0.59A 4dxuA-1jnfA:
50.0		 4dxuA-1jnfA:
30.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqb NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A1260
VAL A1256
PRO A1258
GLY A1282
GLU A1280
 None
 1.23A 4dxuA-1jqbA:
undetectable		 4dxuA-1jqbA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksr GELATION FACTOR

(Dictyostelium
discoideum) 		PF00630
(Filamin) 		4 GLY A  33
VAL A  29
PRO A  31
GLU A   4
 None
 0.69A 4dxuA-1ksrA:
undetectable		 4dxuA-1ksrA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE

(Escherichia
coli) 		PF13406
(SLT_2) 		4 GLY A 170
VAL A 168
GLY A 224
TYR A 223
 None
 0.87A 4dxuA-1ltmA:
undetectable		 4dxuA-1ltmA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 GLY A 434
PRO A 595
GLY A 664
TYR A 667
 None
 0.50A 4dxuA-1n76A:
52.9		 4dxuA-1n76A:
68.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 GLY A 480
VAL A 433
PRO A 432
GLY A 548
GLU A 579
 None
 1.39A 4dxuA-1nl3A:
undetectable		 4dxuA-1nl3A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyn HYPOTHETICAL 12.0
KDA PROTEIN IN
NAM8-GAR1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF01172
(SBDS) 		4 GLY A  61
PRO A  50
GLY A  55
GLU A  57
 None
 0.62A 4dxuA-1nynA:
undetectable		 4dxuA-1nynA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE

(Thermotoga
maritima) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 GLY A 338
VAL A 364
GLY A 413
TYR A 414
 None
 0.86A 4dxuA-1o5zA:
undetectable		 4dxuA-1o5zA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osn THYMIDINE KINASE

(Human
alphaherpesvirus
3) 		PF00693
(Herpes_TK) 		4 GLY A 167
PRO A 318
GLY A  11
TYR A 123
 None
 0.82A 4dxuA-1osnA:
undetectable		 4dxuA-1osnA:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		4 GLY A 432
PRO A 593
GLY A 662
TYR A 665
 None
 0.64A 4dxuA-1qjmA:
53.2		 4dxuA-1qjmA:
45.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 GLY A  43
VAL A  47
PRO A  45
GLY A  93
 None
 0.86A 4dxuA-1rzvA:
undetectable		 4dxuA-1rzvA:
23.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1suv SEROTRANSFERRIN,
C-LOBE

(Homo sapiens) 		PF00405
(Transferrin) 		4 GLY E 424
PRO E 580
GLY E 649
TYR E 652
 None
 0.59A 4dxuA-1suvE:
49.8		 4dxuA-1suvE:
58.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xo8 AT1G01470

(Arabidopsis
thaliana) 		PF03168
(LEA_2) 		5 GLY A 130
VAL A 129
PRO A 127
GLU A  23
TYR A  51
 None
 1.07A 4dxuA-1xo8A:
undetectable		 4dxuA-1xo8A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT

(Hyphomicrobium
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 GLY A 518
VAL A 516
GLY A 410
GLU A 471
 None
 0.82A 4dxuA-2d0vA:
undetectable		 4dxuA-2d0vA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		4 GLY A 469
VAL A 664
GLY A 397
TYR A 400
 None
 0.75A 4dxuA-2d3iA:
50.5		 4dxuA-2d3iA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 GLY A 361
VAL A 351
PRO A 353
GLY A 394
GLU A 393
 None
 1.25A 4dxuA-2ehqA:
2.1		 4dxuA-2ehqA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785

(Thermus
thermophilus) 		PF01139
(RtcB) 		4 GLY A 279
VAL A  87
PRO A 273
GLY A  84
 None
 0.77A 4dxuA-2epgA:
undetectable		 4dxuA-2epgA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 GLY A 531
PRO A 529
GLY A 329
GLU A 244
 None
SF4  A 610 ( 4.3A)
None
None
 0.88A 4dxuA-2gmhA:
undetectable		 4dxuA-2gmhA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Thermotoga
maritima) 		PF04204
(HTS) 		4 VAL A 221
GLY A 217
GLU A 212
TYR A 219
 None
 0.83A 4dxuA-2h2wA:
undetectable		 4dxuA-2h2wA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hau SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		5 GLY A 425
PRO A 583
GLY A 652
GLU A 654
TYR A 655
 None
 0.93A 4dxuA-2hauA:
26.9		 4dxuA-2hauA:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7x PROTEIN CFT2

(Saccharomyces
cerevisiae) 		PF16661
(Lactamase_B_6) 		4 GLY A 162
VAL A  93
PRO A 160
GLY A 252
 None
 0.83A 4dxuA-2i7xA:
undetectable		 4dxuA-2i7xA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jd4 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2) 		4 GLY A2892
VAL A2889
GLY A2916
TYR A3002
 None
 0.73A 4dxuA-2jd4A:
undetectable		 4dxuA-2jd4A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxm CYTOCHROME F

(Prochlorothrix
hollandica) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		4 GLY B 165
VAL B 161
PRO B 163
TYR B   4
 None
HEC  B 250 (-4.8A)
HEC  B 250 (-2.5A)
HEC  B 250 ( 4.7A)
 0.74A 4dxuA-2jxmB:
undetectable		 4dxuA-2jxmB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrn THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Bacteroides sp.
4_3_47FAA) 		PF00578
(AhpC-TSA) 		4 GLY A 120
VAL A 116
PRO A 118
TYR A  31
 None
 0.85A 4dxuA-2lrnA:
undetectable		 4dxuA-2lrnA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nc2 ANTIFUNGAL PROTEIN

(Penicillium
chrysogenum) 		PF11402
(Antifungal_prot) 		4 GLY A  19
GLY A   3
GLU A   5
TYR A  15
 None
 0.88A 4dxuA-2nc2A:
undetectable		 4dxuA-2nc2A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		4 GLY A  70
VAL A 108
PRO A 110
GLU A 102
 None
 0.80A 4dxuA-2pbgA:
undetectable		 4dxuA-2pbgA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLY A 395
VAL A 385
PRO A 392
GLY A 186
 None
 0.89A 4dxuA-2qygA:
undetectable		 4dxuA-2qygA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r37 GLUTATHIONE
PEROXIDASE 3

(Homo sapiens) 		PF00255
(GSHPx) 		4 GLY A 192
VAL A 188
PRO A 190
GLY A  93
 None
 0.85A 4dxuA-2r37A:
undetectable		 4dxuA-2r37A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8b UNCHARACTERIZED
PROTEIN ATU2452

(Agrobacterium
fabrum) 		PF01738
(DLH) 		4 GLY A  59
VAL A  57
PRO A  61
GLY A 246
 None
 0.87A 4dxuA-2r8bA:
undetectable		 4dxuA-2r8bA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica) 		PF06917
(Pectate_lyase_2) 		4 GLY A  42
VAL A  37
PRO A  39
GLY A 469
 None
 0.77A 4dxuA-2v8jA:
undetectable		 4dxuA-2v8jA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc1 FLAVODOXIN

(Rhodobacter
capsulatus) 		PF00258
(Flavodoxin_1) 		4 GLY A  98
VAL A 108
PRO A  56
GLY A  54
 FMN  A 183 (-3.2A)
FMN  A 183 (-4.1A)
FMN  A 183 (-4.2A)
None
 0.84A 4dxuA-2wc1A:
2.1		 4dxuA-2wc1A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9v ASPARTATE
AMINOTRANSFERASE

(Mesorhizobium
loti) 		PF00266
(Aminotran_5) 		4 GLY A 200
PRO A 202
GLY A 204
GLU A  68
 None
None
None
PXM  A1501 (-3.2A)
 0.86A 4dxuA-2z9vA:
undetectable		 4dxuA-2z9vA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN

(Thermosynechococcus
vulcanus) 		PF00421
(PSII) 		4 GLY B 196
VAL B 181
PRO B 183
GLY B 154
 None
 0.83A 4dxuA-3a0hB:
undetectable		 4dxuA-3a0hB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		4 GLY A 460
VAL A 455
PRO A 457
GLY A 430
 None
 0.85A 4dxuA-3a5iA:
undetectable		 4dxuA-3a5iA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agk PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1

(Aeropyrum
pernix) 		PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 GLY A 364
VAL A 307
GLY A 314
GLU A 312
 None
 0.86A 4dxuA-3agkA:
undetectable		 4dxuA-3agkA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLY A 476
VAL A 430
GLY A 509
GLU A 511
 None
 0.89A 4dxuA-3bc9A:
undetectable		 4dxuA-3bc9A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ea0 ATPASE, PARA FAMILY

(Chlorobaculum
tepidum) 		PF13614
(AAA_31) 		4 GLY A  15
VAL A 144
GLY A   5
GLU A 140
 ATP  A 243 (-3.8A)
None
None
None
 0.86A 4dxuA-3ea0A:
undetectable		 4dxuA-3ea0A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 260
VAL A 256
PRO A 258
GLY A 282
GLU A 280
 None
None
None
None
PGE  A 357 (-4.5A)
 1.23A 4dxuA-3fplA:
undetectable		 4dxuA-3fplA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 260
VAL A 256
PRO A 258
GLY A 282
GLU A 280
 ZN  A 354 (-4.3A)
None
None
None
None
 1.26A 4dxuA-3fsrA:
undetectable		 4dxuA-3fsrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M) 		4 GLY A 101
VAL A  97
PRO A  99
GLY A 171
 None
 0.75A 4dxuA-3fsxA:
undetectable		 4dxuA-3fsxA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Aquifex
aeolicus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 GLY B 342
PRO B 340
GLY B 311
TYR B 310
 None
 0.82A 4dxuA-3h0rB:
undetectable		 4dxuA-3h0rB:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]

(Escherichia
coli) 		PF00171
(Aldedh) 		5 VAL A 448
PRO A 450
GLY A 467
GLU A 121
TYR A 466
 None
 1.36A 4dxuA-3jz4A:
undetectable		 4dxuA-3jz4A:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		4 GLY A 426
PRO A 586
GLY A 654
TYR A 657
 None
 0.60A 4dxuA-3mc2A:
17.0		 4dxuA-3mc2A:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus scrofa) 		PF00287
(Na_K-ATPase) 		4 GLY B 237
PRO B 210
GLY B 280
TYR B 279
 None
 0.77A 4dxuA-3n23B:
undetectable		 4dxuA-3n23B:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE

(Methylobacillus
flagellatus) 		PF14403
(CP_ATPgrasp_2) 		4 GLY A 296
VAL A 253
PRO A 295
GLY A 248
 None
 0.87A 4dxuA-3n6xA:
undetectable		 4dxuA-3n6xA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1j PHD FINGER PROTEIN
20

(Homo sapiens) 		PF02820
(MBT) 		4 PRO A   5
GLY A  41
GLU A  39
TYR A  38
 None
 0.73A 4dxuA-3q1jA:
undetectable		 4dxuA-3q1jA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 VAL A 337
PRO A 350
GLY A 133
TYR A 132
 None
 0.85A 4dxuA-3s9vA:
undetectable		 4dxuA-3s9vA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfw DIHYDROPYRIMIDINASE

(Brevibacillus
agri) 		PF01979
(Amidohydro_1) 		4 GLY A 425
VAL A 400
PRO A 398
GLY A  47
 None
None
ACT  A 463 ( 4.7A)
ACT  A 463 (-3.8A)
 0.80A 4dxuA-3sfwA:
undetectable		 4dxuA-3sfwA:
23.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3skp SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 GLY A 425
PRO A 583
GLY A 652
TYR A 655
 None
None
SO4  A 683 (-3.4A)
None
 0.75A 4dxuA-3skpA:
25.6		 4dxuA-3skpA:
59.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4j NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 GLY A 403
VAL A 353
GLY A 370
GLU A 372
 None
 0.83A 4dxuA-3u4jA:
undetectable		 4dxuA-3u4jA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 GLY A 405
VAL A 361
PRO A 363
GLY A 313
 None
 0.80A 4dxuA-3ufbA:
undetectable		 4dxuA-3ufbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE

(Escherichia
coli) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 GLY A 200
VAL A 205
PRO A 172
TYR A 388
 GLY  A 200 ( 0.0A)
VAL  A 205 ( 0.6A)
PRO  A 172 ( 1.1A)
TYR  A 388 ( 1.3A)
 0.84A 4dxuA-3ulkA:
undetectable		 4dxuA-3ulkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0t PERAKINE REDUCTASE

(Rauvolfia
serpentina) 		PF00248
(Aldo_ket_red) 		5 GLY A  99
VAL A 132
PRO A 101
GLY A 139
GLU A 135
 None
 1.30A 4dxuA-3v0tA:
undetectable		 4dxuA-3v0tA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi3 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 GLY A 255
PRO A 253
GLY A 232
TYR A 233
 None
 0.81A 4dxuA-3vi3A:
undetectable		 4dxuA-3vi3A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		4 GLY A 584
PRO A 481
GLY A 484
GLU A 580
 None
 0.85A 4dxuA-3wstA:
undetectable		 4dxuA-3wstA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Zymomonas
mobilis) 		PF00724
(Oxidored_FMN) 		4 GLY A  65
PRO A  67
GLY A  27
TYR A  68
 None
 0.83A 4dxuA-4a3uA:
undetectable		 4dxuA-4a3uA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		4 GLY A 318
VAL A 313
PRO A 315
TYR A 275
 None
 0.86A 4dxuA-4cvcA:
undetectable		 4dxuA-4cvcA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE

(Pseudomonas
aeruginosa) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 GLY A 214
VAL A 177
GLY A 171
GLU A 172
TYR A 175
 None
 1.43A 4dxuA-4cvmA:
undetectable		 4dxuA-4cvmA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		4 GLY A 372
VAL A 364
PRO A 358
GLY A 400
 None
 0.86A 4dxuA-4dwqA:
undetectable		 4dxuA-4dwqA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqk POLYMERASE BASIC
PROTEIN 2

(Influenza A
virus) 		PF00604
(Flu_PB2) 		4 VAL A 463
PRO A 465
GLY A 450
GLU A 452
 None
 0.81A 4dxuA-4eqkA:
undetectable		 4dxuA-4eqkA:
19.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fim LACTOTRANSFERRIN

(Bos taurus) 		PF00405
(Transferrin) 		6 GLY A 432
VAL A 591
PRO A 593
GLY A 662
GLU A 664
TYR A 665
 CEL  A 711 (-3.7A)
None
CEL  A 711 (-4.3A)
CEL  A 711 (-3.3A)
NAG  A 708 (-4.8A)
CEL  A 711 (-4.5A)
 0.37A 4dxuA-4fimA:
61.0		 4dxuA-4fimA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 GLY M 225
VAL M  91
PRO M 223
GLY M 137
 None
 0.83A 4dxuA-4heaM:
undetectable		 4dxuA-4heaM:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxx METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 GLY A 302
PRO A 316
GLY A 282
TYR A 318
 None
 0.87A 4dxuA-4hxxA:
undetectable		 4dxuA-4hxxA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		4 GLY A 222
PRO A 220
GLY A 164
TYR A 165
 None
 0.89A 4dxuA-4iv9A:
undetectable		 4dxuA-4iv9A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpq UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF16011
(CBM9_2) 		4 GLY A 211
VAL A 124
GLY A 128
GLU A 127
 None
None
None
SO4  A 304 ( 4.2A)
 0.89A 4dxuA-4jpqA:
undetectable		 4dxuA-4jpqA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 4 GLY A 190
VAL A 192
PRO A 147
GLY A 120
 None
 0.89A 4dxuA-4lgnA:
undetectable		 4dxuA-4lgnA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		4 PRO A 478
GLY A 376
GLU A 373
TYR A 375
 None
 0.88A 4dxuA-4madA:
undetectable		 4dxuA-4madA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE

(Ketogulonicigenium
vulgare) 		PF13360
(PQQ_2) 		4 GLY A 266
VAL A 261
PRO A 263
TYR A 223
 None
 0.87A 4dxuA-4mh1A:
undetectable		 4dxuA-4mh1A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF00007
(Cys_knot)
PF13416
(SBP_bac_8) 		4 GLY A  18
VAL A 295
PRO A 300
GLY A 302
 None
 0.85A 4dxuA-4my2A:
5.0		 4dxuA-4my2A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 GLY A 105
VAL A  93
PRO A  91
GLY A  74
 None
 0.66A 4dxuA-4nenA:
undetectable		 4dxuA-4nenA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo2 CHLOROPHENOL-4-MONOO
XYGENASE

(Streptomyces
globisporus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 VAL A 156
GLY A  23
GLU A  25
TYR A  26
 None
 0.87A 4dxuA-4oo2A:
undetectable		 4dxuA-4oo2A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p08 COCAINE ESTERASE

(Rhodococcus sp.
MB1) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 GLY A 109
VAL A 111
PRO A  36
TYR A  67
 None
 0.88A 4dxuA-4p08A:
undetectable		 4dxuA-4p08A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV

(Bacteroides
ovatus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 GLY A  38
VAL A 718
PRO A  36
GLY A 536
 None
 0.67A 4dxuA-4q1vA:
undetectable		 4dxuA-4q1vA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlp ALANINE AND PROLINE
RICH PROTEIN,
TUBERCULOSIS
NECROTIZING TOXIN
(TNT)

(Mycobacterium
tuberculosis) 		PF14021
(TNT) 		4 GLY B 721
VAL B 717
PRO B 719
GLU B 655
 None
 0.83A 4dxuA-4qlpB:
undetectable		 4dxuA-4qlpB:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Rhizobium etli) 		PF01547
(SBP_bac_1) 		4 GLY A 302
PRO A 375
GLY A 127
GLU A 132
 None
 0.87A 4dxuA-4rk2A:
6.0		 4dxuA-4rk2A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Desulfitobacterium
hafniense) 		PF13472
(Lipase_GDSL_2) 		4 GLY A 220
VAL A  78
PRO A  76
GLY A  66
 None
 0.81A 4dxuA-4rshA:
undetectable		 4dxuA-4rshA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 4 GLY B 539
VAL B 537
GLY B 437
GLU B 492
 None
 0.88A 4dxuA-4tqoB:
undetectable		 4dxuA-4tqoB:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 GLY A  54
PRO A  41
GLY A  20
TYR A  18
 None
 0.86A 4dxuA-4um8A:
undetectable		 4dxuA-4um8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wib MAGNESIUM
TRANSPORTER MGTE

(Thermus
thermophilus) 		PF01769
(MgtE) 		4 GLY A 327
VAL A 398
GLY A 405
GLU A 359
 None
 0.88A 4dxuA-4wibA:
undetectable		 4dxuA-4wibA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjb PUTATIVE
AMIDOHYDROLASE/PEPTI
DASE

(Burkholderia
cenocepacia) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLY A 135
PRO A 140
GLY A 157
TYR A 152
 None
 0.75A 4dxuA-4wjbA:
undetectable		 4dxuA-4wjbA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk4 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP) 		4 GLY A 255
PRO A 253
GLY A 232
TYR A 233
 None
 0.87A 4dxuA-4wk4A:
undetectable		 4dxuA-4wk4A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xae FERULOYL COA
ORTHO-HYDROXYLASE 1

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 GLY A 299
PRO A 224
GLY A  34
GLU A  32
 None
 0.80A 4dxuA-4xaeA:
undetectable		 4dxuA-4xaeA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaj MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR
RECEPTOR SUBFAMILY 2
GROUP E MEMBER 1

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 GLY A  18
VAL A 295
PRO A 300
GLY A 302
 None
 0.82A 4dxuA-4xajA:
5.8		 4dxuA-4xajA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yla AROMATIC
PRENYLTRANSFERASE

(Marinactinospora
thermotolerans) 		PF11991
(Trp_DMAT) 		4 GLY A  68
GLY A 122
GLU A 124
TYR A 125
 None
 0.87A 4dxuA-4ylaA:
undetectable		 4dxuA-4ylaA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywk CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 GLY A  67
VAL A  60
PRO A  64
GLY A 225
 None
 0.77A 4dxuA-4ywkA:
undetectable		 4dxuA-4ywkA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywl CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 GLY A  67
VAL A  60
PRO A  64
GLY A 225
 None
 0.75A 4dxuA-4ywlA:
undetectable		 4dxuA-4ywlA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpl PROTEIN PCDHB1

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 GLY A  54
VAL A  28
GLY A  35
GLU A  33
 None
 0.86A 4dxuA-4zplA:
undetectable		 4dxuA-4zplA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA+,K+-ATPASE BETA
SUBUNIT

(Squalus
acanthias) 		PF00287
(Na_K-ATPase) 		4 GLY B 239
PRO B 212
GLY B 282
TYR B 281
 None
 0.68A 4dxuA-5aw4B:
undetectable		 4dxuA-5aw4B:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbk SHHTL5

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		4 GLY A 163
VAL A 162
GLY A 156
TYR A 157
 None
None
PE3  A 302 ( 3.8A)
None
 0.83A 4dxuA-5cbkA:
undetectable		 4dxuA-5cbkA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6c 4497 ANTIBODY IGG1
(VH AND CH1)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY B  16
VAL B  12
PRO B  14
GLY B  84
 None
 0.82A 4dxuA-5d6cB:
undetectable		 4dxuA-5d6cB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCOP1

(Pseudomonas
stutzeri) 		PF13442
(Cytochrome_CBB3)
PF14715
(FixP_N) 		4 VAL C 103
GLY C 111
GLU C 108
TYR C 110
 None
 0.87A 4dxuA-5djqC:
undetectable		 4dxuA-5djqC:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		4 GLY A 296
GLY A 361
GLU A 362
TYR A 363
 None
None
EDO  A 623 ( 4.9A)
None
 0.86A 4dxuA-5ecuA:
undetectable		 4dxuA-5ecuA:
21.04