SIMILAR PATTERNS OF AMINO ACIDS FOR 4DX7_B_DM2B1104

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj4 TROPONIN C

(Gallus gallus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 SER A  89
GLN A  50
ILE A  61
VAL A  72
 None
 0.89A 4dx7B-1aj4A:
undetectable		 4dx7B-1aj4A:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aw1 TRIOSEPHOSPHATE
ISOMERASE

(Moritella
marina) 		PF00121
(TIM) 		4 GLN A 148
GLU A 131
ILE A 196
VAL A 207
 None
 0.95A 4dx7B-1aw1A:
undetectable		 4dx7B-1aw1A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)

(Amycolatopsis
mediterranei) 		PF01041
(DegT_DnrJ_EryC1) 		4 GLU A 314
ILE A 297
VAL A 276
PHE A 295
 None
 1.01A 4dx7B-1b9hA:
undetectable		 4dx7B-1b9hA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16) 		4 SER B 249
GLN B 252
ILE B 241
VAL B 305
 None
 0.95A 4dx7B-1ezvB:
3.4		 4dx7B-1ezvB:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		4 SER A  99
ILE A 173
VAL A 314
PHE A 176
 None
 0.99A 4dx7B-1hlgA:
0.1		 4dx7B-1hlgA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC

(Canis lupus) 		PF00561
(Abhydrolase_1) 		4 SER A  99
ILE A 173
VAL A 314
PHE A 176
 None
 0.97A 4dx7B-1k8qA:
undetectable		 4dx7B-1k8qA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4j A6 GENE PRODUCT

(Mus musculus) 		PF00241
(Cofilin_ADF) 		4 GLN A  65
PHE A 122
ILE A  86
VAL A 129
 None
 0.97A 4dx7B-1m4jA:
undetectable		 4dx7B-1m4jA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7d INTEGRASE

(Escherichia
virus Lambda) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		4 GLU A 319
GLN A 328
ILE A 240
VAL A 238
 None
 0.99A 4dx7B-1p7dA:
undetectable		 4dx7B-1p7dA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1l CHORISMATE SYNTHASE

(Aquifex
aeolicus) 		PF01264
(Chorismate_synt) 		4 PHE A 163
ILE A 201
VAL A 172
PHE A 203
 None
 0.98A 4dx7B-1q1lA:
2.5		 4dx7B-1q1lA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnr ENDO-1,4-B-D-MANNANA
SE

(Trichoderma
reesei) 		PF00150
(Cellulase) 		4 SER A 294
ILE A  14
VAL A   5
PHE A  12
 None
 0.98A 4dx7B-1qnrA:
undetectable		 4dx7B-1qnrA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9h FK506 BINDING
PROTEIN FAMILY

(Caenorhabditis
elegans) 		PF00254
(FKBP_C) 		4 SER A  53
ILE A  90
VAL A  16
PHE A  88
 None
 0.87A 4dx7B-1r9hA:
undetectable		 4dx7B-1r9hA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp0 THIAZOLE
BIOSYNTHETIC ENZYME

(Arabidopsis
thaliana) 		PF01946
(Thi4) 		4 GLN A  65
ILE A  69
VAL A 141
PHE A 138
 None
 0.67A 4dx7B-1rp0A:
undetectable		 4dx7B-1rp0A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td6 HYPOTHETICAL PROTEIN
MG237 HOMOLOG

(Mycoplasma
pneumoniae) 		PF11428
(DUF3196) 		4 GLU A 273
PHE A 207
ILE A 211
VAL A   9
 None
 0.98A 4dx7B-1td6A:
undetectable		 4dx7B-1td6A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmh TRIOSEPHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00121
(TIM) 		4 GLN A 148
GLU A 131
ILE A 196
VAL A 207
 None
 1.01A 4dx7B-1tmhA:
undetectable		 4dx7B-1tmhA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txk GLUCANS BIOSYNTHESIS
PROTEIN G

(Escherichia
coli) 		PF04349
(MdoG) 		4 SER A 300
GLU A 352
PHE A 427
VAL A 477
 None
 0.94A 4dx7B-1txkA:
undetectable		 4dx7B-1txkA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vic 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Haemophilus
influenzae) 		PF02348
(CTP_transf_3) 		4 SER A  74
GLU A 214
ILE A   7
VAL A  33
 None
 0.99A 4dx7B-1vicA:
undetectable		 4dx7B-1vicA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpk DNA POLYMERASE III,
BETA SUBUNIT

(Thermotoga
maritima) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 GLU A 117
ILE A  62
VAL A   3
PHE A  42
 None
 0.96A 4dx7B-1vpkA:
undetectable		 4dx7B-1vpkA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 GLN A 512
ILE A 471
VAL A 469
PHE A 425
 None
 1.01A 4dx7B-1w1kA:
2.6		 4dx7B-1w1kA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Pyrococcus
horikoshii) 		PF00117
(GATase) 		4 GLU A 113
PHE A 139
ILE A 150
VAL A 132
 SNN  A 112 ( 3.2A)
None
None
None
 0.94A 4dx7B-1wl8A:
undetectable		 4dx7B-1wl8A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ya0 SMG-7 TRANSCRIPT
VARIANT 2

(Homo sapiens) 		PF10373
(EST1_DNA_bind)
PF10374
(EST1) 		4 GLU A 172
GLN A 292
ILE A 250
VAL A 246
 None
 0.97A 4dx7B-1ya0A:
3.4		 4dx7B-1ya0A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 SER A 546
GLN A 600
ILE A 516
VAL A 513
 None
 1.01A 4dx7B-1z68A:
undetectable		 4dx7B-1z68A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvt CONSERVED
HYPOTHETICAL PROTEIN

(Rhodopseudomonas
palustris) 		PF04430
(DUF498) 		4 SER A  34
PHE A  62
ILE A  68
VAL A  95
 None
 0.93A 4dx7B-2fvtA:
undetectable		 4dx7B-2fvtA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5g PUTATIVE LIPOPROTEIN

(Campylobacter
jejuni) 		PF04187
(Cofac_haem_bdg) 		4 SER X  70
GLN X  71
ILE X  42
VAL X 241
 None
 0.95A 4dx7B-2g5gX:
undetectable		 4dx7B-2g5gX:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk9 PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE II,
GAMMA

(Homo sapiens) 		PF01504
(PIP5K) 		4 PHE A 207
ILE A 143
VAL A 150
PHE A 141
 None
 0.97A 4dx7B-2gk9A:
undetectable		 4dx7B-2gk9A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk9 PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE II,
GAMMA

(Homo sapiens) 		PF01504
(PIP5K) 		4 SER A  63
GLN A  64
ILE A  82
VAL A  84
 None
 1.01A 4dx7B-2gk9A:
undetectable		 4dx7B-2gk9A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtx METHIONINE
AMINOPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		4 SER A 188
GLU A 190
ILE A 214
VAL A 223
 None
 0.94A 4dx7B-2gtxA:
undetectable		 4dx7B-2gtxA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		4 GLN A 315
PHE A 221
ILE A 403
VAL A 399
 UDP  A1424 (-3.4A)
None
None
None
 0.77A 4dx7B-2iyaA:
undetectable		 4dx7B-2iyaA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kk4 UNCHARACTERIZED
PROTEIN AF_2094

(Archaeoglobus
fulgidus) 		no annotation 4 GLU A  65
ILE A  55
VAL A  11
PHE A  18
 None
 1.03A 4dx7B-2kk4A:
undetectable		 4dx7B-2kk4A:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE

(Sulfolobus
acidocaldarius) 		PF00701
(DHDPS) 		4 SER A  87
ILE A   4
VAL A 193
PHE A  38
 None
 1.01A 4dx7B-2nuxA:
undetectable		 4dx7B-2nuxA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq2 PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF01507
(PAPS_reduct) 		4 GLU A 208
ILE A 104
VAL A 106
PHE A  75
 None
 0.88A 4dx7B-2oq2A:
undetectable		 4dx7B-2oq2A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p24 H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN, A-U ALPHA
CHAIN

(Mus musculus) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 GLN A  21
GLU A  25
ILE A 119
VAL A 165
 None
 0.98A 4dx7B-2p24A:
undetectable		 4dx7B-2p24A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4h VESTITONE REDUCTASE

(Medicago sativa) 		PF01370
(Epimerase) 		4 SER X  71
ILE X 184
VAL X 186
PHE X 124
 None
 0.89A 4dx7B-2p4hX:
undetectable		 4dx7B-2p4hX:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 GLU A 307
GLN A 300
ILE A  95
PHE A  99
 None
None
None
NAD  A 401 (-3.3A)
 0.88A 4dx7B-2plaA:
2.5		 4dx7B-2plaA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 GLN A  73
ILE A  67
VAL A  94
PHE A  97
 None
 1.00A 4dx7B-2pxjA:
undetectable		 4dx7B-2pxjA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		4 GLN A  88
GLU A 100
GLN A 113
ILE A 118
 None
 0.95A 4dx7B-2q3yA:
2.1		 4dx7B-2q3yA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv6 GTP CYCLOHYDROLASE
III

(Methanocaldococcus
jannaschii) 		PF05165
(GCH_III) 		4 SER A 189
GLN A 133
ILE A 236
VAL A 241
 None
 1.00A 4dx7B-2qv6A:
5.4		 4dx7B-2qv6A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4v GH59 GALACTOSIDASE

([Clostridium]
cellulolyticum) 		PF03422
(CBM_6) 		4 SER A 932
GLU A 929
ILE A 989
VAL A1020
 None
NA  A3052 (-3.4A)
None
None
 0.94A 4dx7B-2v4vA:
undetectable		 4dx7B-2v4vA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrt RIBONUCLEASE E

(Escherichia
coli) 		PF00575
(S1)
PF10150
(RNase_E_G) 		4 SER A 267
GLU A 272
ILE A 231
VAL A 236
 None
 0.98A 4dx7B-2vrtA:
undetectable		 4dx7B-2vrtA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsu PUTATIVE FIBER
PROTEIN

(Porcine
mastadenovirus
B) 		PF00337
(Gal-bind_lectin) 		4 SER A 512
PHE A 499
ILE A 489
VAL A 497
 None
 1.00A 4dx7B-2wsuA:
undetectable		 4dx7B-2wsuA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 GLN A 476
GLU A 484
ILE A 468
VAL A 227
 B12  A 800 (-3.9A)
None
None
B12  A 800 (-4.5A)
 0.95A 4dx7B-2xijA:
undetectable		 4dx7B-2xijA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		4 SER A 871
ILE A 803
VAL A 318
PHE A 315
 None
 0.89A 4dx7B-2yn9A:
2.1		 4dx7B-2yn9A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cny INOSITOL CATABOLISM
PROTEIN IOLE

(Lactobacillus
plantarum) 		PF01261
(AP_endonuc_2) 		4 SER A 109
GLN A 111
PHE A 243
ILE A  16
 None
 0.98A 4dx7B-3cnyA:
undetectable		 4dx7B-3cnyA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA) 		4 GLN A 132
GLN A 139
ILE A 239
VAL A 149
 None
 0.99A 4dx7B-3e9mA:
undetectable		 4dx7B-3e9mA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emu LEUCINE RICH REPEAT
AND PHOSPHATASE
DOMAIN CONTAINING
PROTEIN

(Entamoeba
histolytica) 		PF00782
(DSPc) 		4 GLN A 443
PHE A 440
ILE A 407
VAL A 345
 None
 1.00A 4dx7B-3emuA:
undetectable		 4dx7B-3emuA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		4 GLN A 195
GLU A 191
ILE A 245
VAL A 248
 None
 0.97A 4dx7B-3fcrA:
undetectable		 4dx7B-3fcrA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7k 3-METHYLITACONATE
ISOMERASE

(Eubacterium
barkeri) 		PF04303
(PrpF) 		4 SER A  44
GLN A  49
GLN A  82
PHE A 295
 None
 0.90A 4dx7B-3g7kA:
0.0		 4dx7B-3g7kA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h05 UNCHARACTERIZED
PROTEIN VPA0413

(Vibrio
parahaemolyticus) 		PF01467
(CTP_transf_like) 		4 SER A  82
ILE A 122
VAL A 128
PHE A 103
 None
 0.72A 4dx7B-3h05A:
undetectable		 4dx7B-3h05A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis) 		PF01266
(DAO) 		4 GLN A 212
PHE A 209
ILE A 321
VAL A 198
 None
FAD  A 371 (-4.7A)
None
None
 0.92A 4dx7B-3if9A:
undetectable		 4dx7B-3if9A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3itd 17BETA-HYDROXYSTEROI
D DEHYDROGENASE

(Curvularia
lunata) 		PF13561
(adh_short_C2) 		4 SER A 156
GLN A 131
ILE A  30
VAL A  34
 None
 0.99A 4dx7B-3itdA:
undetectable		 4dx7B-3itdA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		4 SER B 247
GLN B 251
ILE B 224
VAL B 219
 None
 0.95A 4dx7B-3lcvB:
undetectable		 4dx7B-3lcvB:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loy COPPER AMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid) 		4 GLN A  18
ILE A  35
VAL A  67
PHE A  32
 None
 1.02A 4dx7B-3loyA:
undetectable		 4dx7B-3loyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 SER B 614
GLN B 615
ILE B 682
VAL B 711
 None
 0.99A 4dx7B-3o8oB:
undetectable		 4dx7B-3o8oB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8q SHIKIMATE
5-DEHYDROGENASE I
ALPHA

(Vibrio cholerae) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 GLN B 112
GLN B 118
ILE B 239
VAL B 213
 None
 0.93A 4dx7B-3o8qB:
undetectable		 4dx7B-3o8qB:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot2 UNCHARACTERIZED
PROTEIN

(Trichormus
variabilis) 		PF05685
(Uma2) 		4 GLN A 134
PHE A  65
ILE A  81
VAL A  49
 None
 0.95A 4dx7B-3ot2A:
undetectable		 4dx7B-3ot2A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oth CALG1

(Micromonospora
echinospora) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		4 GLN A 282
PHE A 182
ILE A 370
VAL A 366
 TYD  A 393 (-3.5A)
None
None
None
 0.90A 4dx7B-3othA:
undetectable		 4dx7B-3othA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0i METHIONYL-TRNA
FORMYLTRANSFERASE

(Vibrio cholerae) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 GLU A 174
ILE A  30
VAL A  33
PHE A   9
 None
 1.02A 4dx7B-3q0iA:
undetectable		 4dx7B-3q0iA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3q ALKALINE PHOSPHATASE

(Sphingomonas
sp. BSAR-1) 		PF01663
(Phosphodiest) 		4 SER A 131
GLN A 132
ILE A 176
VAL A 186
 None
 0.87A 4dx7B-3q3qA:
2.2		 4dx7B-3q3qA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20

(Saccharomyces
cerevisiae) 		PF03070
(TENA_THI-4)
PF08543
(Phos_pyr_kin) 		4 GLN A 178
ILE A 227
VAL A 216
PHE A 225
 None
 0.98A 4dx7B-3rm5A:
2.1		 4dx7B-3rm5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE

(Helicobacter
pylori) 		PF01370
(Epimerase) 		4 SER A 312
GLU A 311
GLN A 257
ILE A 295
 None
 0.86A 4dx7B-3sxpA:
undetectable		 4dx7B-3sxpA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thg RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE 1,
CHLOROPLASTIC

(Larrea
tridentata) 		no annotation 4 SER A 283
ILE A 272
VAL A 267
PHE A 262
 None
 0.92A 4dx7B-3thgA:
undetectable		 4dx7B-3thgA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 228
PHE A  97
VAL A 397
PHE A 374
 None
 0.94A 4dx7B-3ti8A:
undetectable		 4dx7B-3ti8A:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 SER A  46
GLN A  89
GLU A 130
ILE A 277
VAL A 612
 None
 0.90A 4dx7B-3w9hA:
57.1		 4dx7B-3w9hA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 SER A  46
GLN A  89
GLU A 130
PHE A 178
 None
 0.82A 4dx7B-3w9hA:
57.1		 4dx7B-3w9hA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 SER A  46
GLN A  89
ILE A 277
VAL A 612
PHE A 615
 None
 0.94A 4dx7B-3w9hA:
57.1		 4dx7B-3w9hA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 SER A 634
GLN A 557
PHE A 558
ILE A 479
 None
 0.97A 4dx7B-3wiqA:
undetectable		 4dx7B-3wiqA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 GLU A  82
PHE A 381
ILE A 359
VAL A 363
 None
 0.93A 4dx7B-3x0yA:
3.6		 4dx7B-3x0yA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx2 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 1

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 SER A 251
GLN A 219
ILE A 420
VAL A 365
 None
None
ACY  A 511 ( 3.9A)
None
 0.66A 4dx7B-3zx2A:
undetectable		 4dx7B-3zx2A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 GLU A 511
GLN A 518
PHE A 540
ILE A 541
 None
 0.96A 4dx7B-4a2qA:
2.2		 4dx7B-4a2qA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 GLU A 511
GLN A 518
PHE A 540
ILE A 541
 None
 0.99A 4dx7B-4a2wA:
2.8		 4dx7B-4a2wA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		5 GLU A 296
PHE A 251
ILE A 268
VAL A 272
PHE A 193
 None
 1.25A 4dx7B-4bn5A:
undetectable		 4dx7B-4bn5A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpz ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		4 SER A 248
GLU A 250
ILE A 272
VAL A 227
 None
BGC  A 402 ( 3.4A)
None
None
 0.89A 4dx7B-4bpzA:
undetectable		 4dx7B-4bpzA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4erv RYANODINE RECEPTOR 3

(Homo sapiens) 		PF02026
(RyR) 		4 SER A2625
PHE A2788
ILE A2796
VAL A2686
 None
 0.97A 4dx7B-4ervA:
undetectable		 4dx7B-4ervA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4z DNA POLYMERASE IV

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		no annotation 4 GLN B  82
ILE B 138
VAL B 140
PHE B   8
 None
 0.83A 4dx7B-4f4zB:
4.5		 4dx7B-4f4zB:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g76 PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF14859
(Colicin_M) 		4 SER A 184
ILE A 287
VAL A 285
PHE A 232
 None
 1.01A 4dx7B-4g76A:
undetectable		 4dx7B-4g76A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT

(Streptococcus
pneumoniae) 		PF13458
(Peripla_BP_6) 		4 SER A 187
GLN A 162
PHE A 157
ILE A 154
 None
 0.84A 4dx7B-4gnrA:
undetectable		 4dx7B-4gnrA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grl MHC CLASS II
HLA-DQ-ALPHA CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 GLN A  21
GLU A  25
ILE A 119
VAL A 165
 None
 1.02A 4dx7B-4grlA:
undetectable		 4dx7B-4grlA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum) 		no annotation 4 SER A 163
ILE A 428
VAL A 296
PHE A 424
 EGR  A 501 (-2.6A)
None
None
None
 1.01A 4dx7B-4j0kA:
undetectable		 4dx7B-4j0kA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0q ELONGATION FACTOR
TU-A

(Pseudomonas
putida) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 GLU A  38
ILE A 103
VAL A 105
PHE A 134
 None
 1.02A 4dx7B-4j0qA:
undetectable		 4dx7B-4j0qA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 SER A 622
GLN A 481
ILE A 599
VAL A 603
 None
 0.93A 4dx7B-4lk2A:
undetectable		 4dx7B-4lk2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 SER A 364
GLN A  83
ILE A 335
PHE A 101
 None
 0.86A 4dx7B-4mivA:
undetectable		 4dx7B-4mivA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 228
PHE A  97
VAL A 397
PHE A 374
 None
 0.88A 4dx7B-4mjuA:
undetectable		 4dx7B-4mjuA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLN A 306
PHE A 295
ILE A 343
VAL A 293
 None
 0.90A 4dx7B-4on9A:
undetectable		 4dx7B-4on9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox3 PUTATIVE
CARBOXYPEPTIDASE
YODJ

(Bacillus
subtilis) 		PF02557
(VanY) 		4 SER A 183
PHE A 224
ILE A 226
VAL A 215
 None
 0.96A 4dx7B-4ox3A:
2.5		 4dx7B-4ox3A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		4 GLN A  90
GLN A 237
ILE A 288
PHE A 339
 MRD  A 502 (-3.1A)
MRD  A 501 (-3.8A)
None
MRD  A 502 (-4.6A)
 0.94A 4dx7B-4qfuA:
undetectable		 4dx7B-4qfuA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 2

(Drosophila
melanogaster) 		PF04084
(ORC2) 		4 SER B 486
PHE B 431
ILE B 433
PHE B 368
 None
 0.99A 4dx7B-4xgcB:
undetectable		 4dx7B-4xgcB:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yqz PUTATIVE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		4 GLU A 157
ILE A  63
VAL A  59
PHE A  60
 None
 1.02A 4dx7B-4yqzA:
3.0		 4dx7B-4yqzA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aiw TRAH

(Enterococcus
faecalis) 		no annotation 4 GLN A 150
PHE A  70
ILE A 128
VAL A 144
 None
 0.96A 4dx7B-5aiwA:
undetectable		 4dx7B-5aiwA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 SER A 580
GLN A 601
ILE A 661
VAL A 737
 None
 0.90A 4dx7B-5bp1A:
undetectable		 4dx7B-5bp1A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6

(Saccharomyces
cerevisiae) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 SER A 383
ILE A 196
VAL A 287
PHE A 312
 None
 0.95A 4dx7B-5c0yA:
undetectable		 4dx7B-5c0yA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		4 SER A 358
GLU A 365
ILE A  69
VAL A  74
 None
 0.88A 4dx7B-5cerA:
undetectable		 4dx7B-5cerA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfc VP1
VP3

(Cardiovirus B) 		PF00073
(Rhv)
no annotation 		4 GLU A   6
ILE B 127
VAL B 190
PHE B 125
 None
 0.95A 4dx7B-5cfcA:
undetectable		 4dx7B-5cfcA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwb DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 SER A  49
GLU A  48
ILE A  63
VAL A  14
 None
 0.93A 4dx7B-5cwbA:
5.3		 4dx7B-5cwbA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwb DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 SER A 199
GLU A 198
ILE A 163
VAL A 114
 None
 0.98A 4dx7B-5cwbA:
5.3		 4dx7B-5cwbA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d79 BERBERINE BRIDGE
ENZYME-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 SER A 135
GLN A 148
ILE A 128
VAL A  93
 None
PO4  A 602 (-3.8A)
None
None
 1.02A 4dx7B-5d79A:
undetectable		 4dx7B-5d79A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dku PREX DNA POLYMERASE

(Plasmodium
falciparum) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 SER A 617
GLN A 413
ILE A 418
VAL A 547
 None
 0.92A 4dx7B-5dkuA:
3.5		 4dx7B-5dkuA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e55 CONTACTIN-6

(Mus musculus) 		PF00041
(fn3) 		4 GLU A 766
ILE A 719
VAL A 738
PHE A 740
 None
 1.02A 4dx7B-5e55A:
undetectable		 4dx7B-5e55A:
14.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 SER A  46
GLN A  89
GLU A 130
GLN A 176
PHE A 178
 None
 1.41A 4dx7B-5enoA:
43.3		 4dx7B-5enoA:
73.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 SER A  46
GLN A  89
GLU A 130
ILE A 277
VAL A 612
 None
 0.78A 4dx7B-5enoA:
43.3		 4dx7B-5enoA:
73.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		4 SER z 423
ILE z 118
VAL z 113
PHE z 108
 None
 0.99A 4dx7B-5gw5z:
3.2		 4dx7B-5gw5z:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5isu LMO0135 PROTEIN

(Listeria
monocytogenes) 		PF00496
(SBP_bac_5) 		4 GLN A 344
GLU A 388
GLN A 384
ILE A 378
 None
 1.00A 4dx7B-5isuA:
2.3		 4dx7B-5isuA:
19.18