SIMILAR PATTERNS OF AMINO ACIDS FOR 4DX5_B_MIYB1103

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbj IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  33
ASN H  52
ILE H  51
ALA H  78
PHE H  69
 AE2  H 229 (-3.5A)
None
None
None
None
 1.12A 4dx5B-1dbjH:
2.2		 4dx5B-1dbjH:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		5 SER A  22
ASP A  46
ILE A  47
ALA A  49
VAL A  86
 None
 1.07A 4dx5B-1dj2A:
undetectable		 4dx5B-1dj2A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		5 SER A  21
ASP A  45
ILE A  46
ALA A  48
VAL A  85
 None
 1.06A 4dx5B-1dj3A:
undetectable		 4dx5B-1dj3A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		5 GLY A 246
ASP A 209
ILE A 208
ALA A 253
VAL A 258
 None
 1.14A 4dx5B-1epxA:
0.0		 4dx5B-1epxA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00116
(COX2)
PF06481
(COX_ARM) 		5 SER B  42
ILE B 183
ALA B 185
VAL B 165
PHE B 163
 None
 0.99A 4dx5B-1fftB:
undetectable		 4dx5B-1fftB:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 GLN A  20
PHE A 253
ASN A  10
ASP A   7
ILE A   8
 None
 1.20A 4dx5B-1flgA:
undetectable		 4dx5B-1flgA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gri GROWTH FACTOR BOUND
PROTEIN 2

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1) 		5 PHE A 167
GLY A 176
ILE A 183
ALA A 163
VAL A 210
 None
 1.13A 4dx5B-1griA:
undetectable		 4dx5B-1griA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqz ACTIN-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00241
(Cofilin_ADF) 		5 PHE 1  99
ASP 1   7
ILE 1   6
ALA 1 105
VAL 1 106
 None
 1.18A 4dx5B-1hqz1:
undetectable		 4dx5B-1hqz1:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1

(Homo sapiens) 		PF00415
(RCC1) 		5 GLY B 248
ASN B 181
ASP B 182
ALA B 178
VAL B 185
 None
 1.15A 4dx5B-1i2mB:
0.0		 4dx5B-1i2mB:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmb N9 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 SER N 367
ASN N 325
ASP N 324
VAL N 321
ARG N 300
 None
None
CA  N 478 (-3.5A)
MAN  N 473 ( 4.5A)
None
 1.15A 4dx5B-1nmbN:
undetectable		 4dx5B-1nmbN:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		5 GLN A 351
PHE A  75
GLY A  72
ILE A  28
VAL A  35
 GOL  A 503 (-3.9A)
None
None
None
None
 1.14A 4dx5B-1pz3A:
undetectable		 4dx5B-1pz3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		5 SER A 522
GLY A 333
ASN A 405
ALA A 213
PHE A 400
 None
 1.15A 4dx5B-1ukcA:
undetectable		 4dx5B-1ukcA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		5 GLY A 256
ASP A 227
ALA A 313
VAL A 259
PHE A 229
 None
 1.10A 4dx5B-1ur4A:
undetectable		 4dx5B-1ur4A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 PHE A 717
GLY A 713
SER A 712
ASP A 350
ALA A 355
 None
 1.16A 4dx5B-1v7vA:
undetectable		 4dx5B-1v7vA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5t ORC2

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 GLN A 110
ASN A  93
ASP A 145
ALA A  90
VAL A 142
 None
None
MG  A 701 ( 4.1A)
None
None
 1.13A 4dx5B-1w5tA:
undetectable		 4dx5B-1w5tA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf7 ENIGMA HOMOLOGUE
PROTEIN

(Mus musculus) 		PF00595
(PDZ) 		5 SER A   8
ASN A  81
ASP A  57
ILE A  56
ALA A  61
 None
 0.99A 4dx5B-1wf7A:
undetectable		 4dx5B-1wf7A:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 SER A 368
ASN A 327
ASP A 326
VAL A 323
ARG A 302
 None
 1.09A 4dx5B-1xogA:
undetectable		 4dx5B-1xogA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Actinobacillus
succinogenes) 		PF01293
(PEPCK_ATP) 		5 SER A 217
GLN A 144
PHE A  62
ILE A 202
ALA A 173
 None
 1.06A 4dx5B-1yggA:
undetectable		 4dx5B-1yggA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		5 ASN A  28
ASP A  17
ILE A  18
VAL A  99
PHE A 101
 None
 1.19A 4dx5B-1zapA:
undetectable		 4dx5B-1zapA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		5 GLY A 122
ASN A  28
ASP A  17
VAL A  99
PHE A 101
 None
 1.12A 4dx5B-1zapA:
undetectable		 4dx5B-1zapA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Pyrococcus
abyssi) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		5 GLY C 347
ASP C 339
ALA C 392
VAL C 396
PHE C 337
 None
 1.17A 4dx5B-1zq1C:
2.6		 4dx5B-1zq1C:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE

(Alcaligenaceae
bacterium FB188) 		PF00850
(Hist_deacetyl) 		5 ASP A  69
ILE A  72
ALA A  75
VAL A 160
ARG A 112
 None
 1.02A 4dx5B-1zz3A:
undetectable		 4dx5B-1zz3A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acg PROFILIN II

(Acanthamoeba
castellanii) 		PF00235
(Profilin) 		5 PHE A  60
SER A  57
ASP A  51
ALA A  44
PHE A  49
 None
 1.14A 4dx5B-2acgA:
undetectable		 4dx5B-2acgA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3d MODULATOR OF DRUG
ACTIVITY B

(Escherichia
coli) 		PF02525
(Flavodoxin_2) 		5 SER A  27
PHE A 177
ASP A  33
ALA A  39
VAL A  38
 FAD  A1205 (-2.9A)
None
None
None
None
 1.05A 4dx5B-2b3dA:
undetectable		 4dx5B-2b3dA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl0 MYOSIN REGULATORY
LIGHT CHAIN

(Physarum
polycephalum) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		5 GLN B  49
GLY B  48
ASN B  44
ILE B  46
VAL B  63
 None
 1.14A 4dx5B-2bl0B:
undetectable		 4dx5B-2bl0B:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		5 GLY A 202
ASN A 206
ILE A 200
ALA A 241
VAL A 297
 None
 1.14A 4dx5B-2c07A:
undetectable		 4dx5B-2c07A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c49 SUGAR KINASE MJ0406

(Methanocaldococcus
jannaschii) 		PF00294
(PfkB) 		5 SER A  86
ASP A  82
ILE A  83
ALA A  49
VAL A  50
 None
 1.05A 4dx5B-2c49A:
undetectable		 4dx5B-2c49A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6x CITRATE SYNTHASE 1

(Bacillus
subtilis) 		PF00285
(Citrate_synt) 		5 PHE A  51
GLY A  52
ILE A  49
ALA A 338
VAL A 334
 None
 1.20A 4dx5B-2c6xA:
undetectable		 4dx5B-2c6xA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE

(Pseudomonas
stutzeri) 		PF00202
(Aminotran_3) 		5 GLY A 360
ASN A 331
ASP A 332
ALA A 337
VAL A 421
 None
 1.16A 4dx5B-2cy8A:
undetectable		 4dx5B-2cy8A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fji EXOCYST COMPLEX
COMPONENT SEC6

(Saccharomyces
cerevisiae) 		PF06046
(Sec6) 		5 SER 1 597
ASN 1 651
ILE 1 653
VAL 1 699
PHE 1 696
 None
 0.98A 4dx5B-2fji1:
4.2		 4dx5B-2fji1:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oej 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Geobacillus
kaustophilus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLY A 286
SER A 282
ASP A 322
ALA A 330
PHE A 327
 None
 1.19A 4dx5B-2oejA:
4.1		 4dx5B-2oejA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		5 ASN A  28
ASP A  17
ILE A  18
VAL A  99
PHE A 101
 None
 1.16A 4dx5B-2qzwA:
undetectable		 4dx5B-2qzwA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Desulfovibrio
vulgaris) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 GLN A 234
GLY A 233
ASN A 229
ILE A 231
VAL A 215
 None
 1.17A 4dx5B-2z1uA:
1.7		 4dx5B-2z1uA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajx 3-HEXULOSE-6-PHOSPHA
TE SYNTHASE

(Mycobacterium
gastri) 		PF00215
(OMPdecase) 		5 GLY A1127
ASP A1089
ILE A1092
ALA A1095
ARG A1119
 None
 1.03A 4dx5B-3ajxA:
undetectable		 4dx5B-3ajxA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajx 3-HEXULOSE-6-PHOSPHA
TE SYNTHASE

(Mycobacterium
gastri) 		PF00215
(OMPdecase) 		5 GLY A1127
ASP A1089
ILE A1092
VAL A1083
ARG A1119
 None
 1.17A 4dx5B-3ajxA:
undetectable		 4dx5B-3ajxA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF00535
(Glycos_transf_2) 		5 SER A 130
ASP A 133
ILE A 134
ALA A 219
VAL A 154
 None
 1.19A 4dx5B-3cknA:
undetectable		 4dx5B-3cknA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dui BETA-GALACTOSIDE-BIN
DING LECTIN

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		5 GLY A  22
ASP A 125
ILE A  24
ALA A  84
PHE A  80
 None
 1.04A 4dx5B-3duiA:
undetectable		 4dx5B-3duiA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbl BETA2-MICROGLOBULIN

(Ctenopharyngodon
idella) 		PF07654
(C1-set) 		5 SER A  81
ILE A  46
ALA A  49
VAL A  68
PHE A  70
 None
 1.20A 4dx5B-3gblA:
undetectable		 4dx5B-3gblA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5t TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Corynebacterium
glutamicum) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 PHE A 326
GLY A 325
ASN A 321
ASP A  90
ALA A  96
 None
 1.19A 4dx5B-3h5tA:
undetectable		 4dx5B-3h5tA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7o GROUP 3 ALLERGEN
SMIPP-S YV6023A04

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		5 SER A 107
ASP A  71
ILE A  56
ALA A  17
VAL A  18
 None
 1.01A 4dx5B-3h7oA:
undetectable		 4dx5B-3h7oA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iib PEPTIDASE M28

(Shewanella
amazonensis) 		PF04389
(Peptidase_M28) 		5 GLY A 176
SER A 175
ASP A 141
ALA A 184
PHE A 156
 None
 1.14A 4dx5B-3iibA:
undetectable		 4dx5B-3iibA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m85 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Archaeoglobus
fulgidus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ASN G  82
ASP G 138
ILE G 139
ALA G 141
VAL G  58
 None
 1.19A 4dx5B-3m85G:
undetectable		 4dx5B-3m85G:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1

(Saccharomyces
cerevisiae) 		PF01680
(SOR_SNZ) 		5 ASN A  71
ASP A  68
ILE A  69
ALA A  30
VAL A  24
 None
 1.15A 4dx5B-3o07A:
undetectable		 4dx5B-3o07A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oet ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Salmonella
enterica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 PHE A  84
GLY A  83
ASN A  60
ALA A 273
VAL A 270
 None
 1.18A 4dx5B-3oetA:
undetectable		 4dx5B-3oetA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		5 ASN A 255
ASP A 256
ILE A 257
VAL A 200
ARG A 187
 None
 1.16A 4dx5B-3s1sA:
undetectable		 4dx5B-3s1sA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sg1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
anthracis) 		PF00275
(EPSP_synthase) 		5 SER A 322
ASN A 356
ASP A 345
ILE A 346
VAL A 336
 None
 1.04A 4dx5B-3sg1A:
undetectable		 4dx5B-3sg1A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB

(Methanosarcina
barkeri) 		PF04055
(Radical_SAM) 		5 GLY A 285
ASP A 279
ALA A 276
VAL A 297
ARG A 322
 None
MD0  A 993 (-3.6A)
None
None
None
 0.89A 4dx5B-3t7vA:
undetectable		 4dx5B-3t7vA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqh QUINONE
OXIDOREDUCTASE

(Coxiella
burnetii) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 PHE A  55
GLY A  54
SER A  53
ASP A  46
ILE A  45
 None
None
None
None
SO4  A 319 (-3.9A)
 1.20A 4dx5B-3tqhA:
undetectable		 4dx5B-3tqhA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx8 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Corynebacterium
glutamicum) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLN A 365
ASP A 358
ILE A 362
ALA A 308
VAL A 309
 None
 1.08A 4dx5B-3tx8A:
4.7		 4dx5B-3tx8A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ

(Sphingomonas
sp. A1) 		PF01832
(Glucosaminidase) 		5 GLY A 189
SER A 191
ALA A 182
VAL A 179
ARG A 303
 None
 1.18A 4dx5B-3vwoA:
undetectable		 4dx5B-3vwoA:
10.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		6 GLN A 151
ASP A 276
ILE A 277
ALA A 279
VAL A 612
PHE A 615
 None
 0.82A 4dx5B-3w9hA:
60.6		 4dx5B-3w9hA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		5 SER A  48
GLY A 179
SER A 180
ALA A 279
PHE A 615
 None
 1.01A 4dx5B-3w9iA:
52.1		 4dx5B-3w9iA:
69.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 SER A 168
ASN A 164
ILE A 162
ALA A 268
VAL A 269
 None
 1.09A 4dx5B-4b3iA:
3.9		 4dx5B-4b3iA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bct THAUMATIN-LIKE
PROTEIN

(Actinidia
deliciosa) 		PF00314
(Thaumatin) 		5 PHE A  27
ASN A  54
ILE A  29
ALA A  41
VAL A  68
 None
 1.19A 4dx5B-4bctA:
undetectable		 4dx5B-4bctA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF14574
(DUF4445) 		5 GLY I 466
SER I 465
ASP I 469
ILE I 468
PHE I 486
 None
 0.84A 4dx5B-4c1nI:
undetectable		 4dx5B-4c1nI:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cqm CARBONYL REDUCTASE
FAMILY MEMBER 4

(Homo sapiens) 		PF13561
(adh_short_C2) 		6 GLY B 138
SER B 149
ASN B 142
ILE B 136
ALA B 177
VAL B 228
 None
 1.15A 4dx5B-4cqmB:
undetectable		 4dx5B-4cqmB:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1i BETA-GALACTOSIDASE,
PUTATIVE, BGL35A

(Cellvibrio
japonicus) 		PF02449
(Glyco_hydro_42) 		5 SER A  91
GLY A 351
ASP A 322
ILE A 323
VAL A 331
 None
 1.18A 4dx5B-4d1iA:
undetectable		 4dx5B-4d1iA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48

(Caldicellulosiruptor
bescii) 		PF02011
(Glyco_hydro_48) 		5 PHE A 393
GLY A 395
ASP A 271
ALA A 375
VAL A 320
 None
 1.14A 4dx5B-4el8A:
undetectable		 4dx5B-4el8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0a PROTEIN WNT-8

(Xenopus laevis) 		PF00110
(wnt) 		5 ASN B 207
ASP B 204
ILE B 205
ALA B 172
VAL B 173
 None
 0.93A 4dx5B-4f0aB:
2.7		 4dx5B-4f0aB:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN

(Hahella
chejuensis) 		PF02011
(Glyco_hydro_48) 		5 PHE A 428
GLY A 430
ASP A 302
ALA A 408
VAL A 353
 None
None
None
None
OHI  A 352 ( 3.1A)
 1.06A 4dx5B-4fusA:
2.1		 4dx5B-4fusA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fyu THIOREDOXIN

(Wuchereria
bancrofti) 		PF13905
(Thioredoxin_8) 		5 GLY A  20
SER A  21
ASN A   7
ILE A   8
VAL A  89
 None
 1.14A 4dx5B-4fyuA:
undetectable		 4dx5B-4fyuA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		5 GLY A  60
SER A  61
ILE A  82
ALA A 129
VAL A 139
 GLY  A  60 (-0.0A)
SER  A  61 (-0.0A)
ILE  A  82 (-0.7A)
ALA  A 129 (-0.0A)
VAL  A 139 ( 0.6A)
 0.86A 4dx5B-4g9kA:
undetectable		 4dx5B-4g9kA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 GLY A  60
ILE A   5
ALA A   3
VAL A  77
PHE A  71
 None
 1.16A 4dx5B-4ga6A:
3.3		 4dx5B-4ga6A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkt INOSITOL
2-DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 SER A 219
GLY A 243
SER A 244
ILE A 135
VAL A 131
 None
 0.99A 4dx5B-4hktA:
0.0		 4dx5B-4hktA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkt INOSITOL
2-DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 SER A 219
SER A 244
ILE A 135
ALA A 134
VAL A 131
 None
 1.16A 4dx5B-4hktA:
0.0		 4dx5B-4hktA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iiv 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		5 SER A   2
GLY A  51
ASN A  53
ILE A  47
ALA A  46
 None
 1.18A 4dx5B-4iivA:
2.1		 4dx5B-4iivA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN

(Chaetomium
thermophilum) 		PF00557
(Peptidase_M24) 		5 GLY A  72
ASN A  70
ASP A 117
ILE A 116
ALA A  24
 None
 1.16A 4dx5B-4ipaA:
3.1		 4dx5B-4ipaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdn VIRULENCE PLASMID
PROTEIN PGP3-D

(Chlamydia
trachomatis) 		PF05475
(Chlam_vir) 		5 SER A 194
ASP A 168
ILE A 169
ALA A 171
VAL A 235
 None
 1.06A 4dx5B-4jdnA:
undetectable		 4dx5B-4jdnA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdo VIRULENCE PLASMID
PROTEIN PGP3-D

(Chlamydia
trachomatis) 		PF05475
(Chlam_vir) 		5 SER A 194
ASP A 168
ILE A 169
ALA A 171
VAL A 235
 None
 1.06A 4dx5B-4jdoA:
undetectable		 4dx5B-4jdoA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Conexibacter
woesei) 		PF13407
(Peripla_BP_4) 		5 GLY A 150
SER A 151
ILE A 294
ALA A 295
VAL A 298
 None
GOL  A 501 ( 4.9A)
None
None
None
 1.03A 4dx5B-4kq9A:
undetectable		 4dx5B-4kq9A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE

(Burkholderia
cenocepacia) 		PF01041
(DegT_DnrJ_EryC1) 		5 SER A  60
GLY A  68
ASP A 158
ALA A 128
VAL A  80
 CIT  A 401 (-3.8A)
None
EDO  A 403 (-3.6A)
None
None
 0.98A 4dx5B-4lc3A:
undetectable		 4dx5B-4lc3A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv1 FORMYLTRANSFERASE

(Francisella
tularensis) 		no annotation 5 GLY C  22
SER C  23
ASN C  19
ASP C  16
VAL C   6
 None
 1.20A 4dx5B-4nv1C:
undetectable		 4dx5B-4nv1C:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Shewanella
benthica) 		PF00701
(DHDPS) 		5 ASN A 156
ASP A 127
ILE A 128
ALA A  98
VAL A  97
 None
 1.18A 4dx5B-4pfmA:
undetectable		 4dx5B-4pfmA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qko PYOCIN-S2
PYOCIN-S2 IMMUNITY
PROTEIN

(Pseudomonas
aeruginosa) 		PF01320
(Colicin_Pyocin)
no annotation 		5 GLY B 628
ASP A  19
ILE A  20
VAL A  38
PHE A  41
 None
 1.07A 4dx5B-4qkoB:
undetectable		 4dx5B-4qkoB:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase) 		5 PHE A 315
SER A 419
ILE A 317
ALA A 318
VAL A 470
 None
 1.08A 4dx5B-4u3tA:
undetectable		 4dx5B-4u3tA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 SER A 112
GLY A 237
ILE A 233
ALA A 232
VAL A 229
 FAD  A 601 (-2.7A)
None
None
None
None
 1.12A 4dx5B-4ud8A:
undetectable		 4dx5B-4ud8A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyu PROTEIN SCRIBBLE
HOMOLOG

(Homo sapiens) 		PF00595
(PDZ) 		5 GLY A  30
SER A  36
ILE A  28
ALA A  84
VAL A  85
 None
 1.05A 4dx5B-4wyuA:
undetectable		 4dx5B-4wyuA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
purpureum) 		PF00840
(Glyco_hydro_7) 		5 SER A  98
GLY A  74
SER A   7
ASN A  76
VAL A  33
 None
 1.19A 4dx5B-4zzpA:
undetectable		 4dx5B-4zzpA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpt MGC81278 PROTEIN

(Xenopus laevis) 		PF12894
(ANAPC4_WD40)
PF12896
(ANAPC4) 		5 GLN A 521
SER A 388
ASP A 381
ILE A 525
ALA A 524
 None
 1.20A 4dx5B-5bptA:
2.9		 4dx5B-5bptA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9g ISOCITRATE LYASE

(Magnaporthe
oryzae) 		PF00463
(ICL) 		5 GLY A 199
SER A  61
ILE A 174
ALA A 176
VAL A 105
 None
 1.20A 4dx5B-5e9gA:
undetectable		 4dx5B-5e9gA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5emi CELL WALL
HYDROLASE/AUTOLYSIN

(Nostoc
punctiforme) 		PF01520
(Amidase_3) 		5 SER A 570
ASP A 444
ILE A 443
ALA A 474
VAL A 473
 None
 1.09A 4dx5B-5emiA:
undetectable		 4dx5B-5emiA:
10.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		6 ASP A 276
ILE A 277
ALA A 279
VAL A 612
PHE A 615
ARG A 620
 None
 0.99A 4dx5B-5enoA:
43.5		 4dx5B-5enoA:
73.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		6 GLN A 151
ASP A 276
ILE A 277
VAL A 612
PHE A 615
ARG A 620
 None
 1.14A 4dx5B-5enoA:
43.5		 4dx5B-5enoA:
73.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		6 SER A  48
ASP A 276
ILE A 277
ALA A 279
VAL A 612
PHE A 615
 None
 1.07A 4dx5B-5enoA:
43.5		 4dx5B-5enoA:
73.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz TUBULIN GAMMA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 GLN C  38
SER C  42
ASN C  60
ILE C  31
ALA C  30
 None
 1.18A 4dx5B-5flzC:
undetectable		 4dx5B-5flzC:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikj CRYPTIC LOCI
REGULATOR 2

(Schizosaccharomyces
pombe) 		PF10383
(Clr2)
PF16761
(Clr2_transil) 		5 PHE A 372
GLY A 374
ILE A 319
ALA A 510
VAL A 511
 None
 0.80A 4dx5B-5ikjA:
0.0		 4dx5B-5ikjA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		6 GLY A 284
SER A 283
ILE A 322
ALA A 316
VAL A 317
ARG A 326
 NAG  A 918 (-3.1A)
MAN  A 922 ( 4.6A)
None
NAG  A 917 ( 3.9A)
None
None
 1.44A 4dx5B-5ju6A:
undetectable		 4dx5B-5ju6A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 SER A 540
GLY A 316
SER A 531
ILE A 528
VAL A 508
 None
 1.16A 4dx5B-5k5tA:
undetectable		 4dx5B-5k5tA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 PHE A 315
SER A 419
ILE A 317
ALA A 318
VAL A 470
 None
 1.17A 4dx5B-5kshA:
undetectable		 4dx5B-5kshA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		6 PHE A 383
GLY A 422
SER A 467
ASN A 426
ILE A 446
VAL A 450
 None
 1.43A 4dx5B-5n6uA:
undetectable		 4dx5B-5n6uA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nva PUTATIVE
SODIUM:SOLUTE
SYMPORTER

(Proteus
mirabilis) 		no annotation 5 GLY A 174
ASP A 182
ILE A 179
VAL A  45
ARG A 260
 None
NA  A 502 (-2.1A)
None
None
NA  A 502 ( 4.5A)
 1.12A 4dx5B-5nvaA:
undetectable		 4dx5B-5nvaA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 SER A 716
PHE A 605
GLY A 606
ALA A 543
VAL A 544
 None
 1.18A 4dx5B-5okoA:
undetectable		 4dx5B-5okoA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubc PROTEIN TOC75-3,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 5 GLN A 400
ASP A 365
ILE A 366
VAL A 441
PHE A 404
 None
 1.09A 4dx5B-5ubcA:
undetectable		 4dx5B-5ubcA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj4 UNCHARACTERIZED
PROTEIN

(Borrelia
turicatae) 		no annotation 5 GLY A 190
SER A 189
ILE A 219
VAL A 218
PHE A 184
 None
 1.18A 4dx5B-5vj4A:
2.3		 4dx5B-5vj4A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC

(Medicago
truncatula) 		PF00815
(Histidinol_dh) 		5 ASN A 320
ASP A 318
ILE A 322
ALA A 293
VAL A 292
 None
 1.16A 4dx5B-5vldA:
undetectable		 4dx5B-5vldA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu5 ENDO-1,4-BETA-MANNAN
ASE

(Rhizopus
microsporus) 		no annotation 5 GLY B 119
SER B 118
ASP B 127
ILE B 128
PHE B 110
 None
 1.20A 4dx5B-5xu5B:
undetectable		 4dx5B-5xu5B:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN

(Homo sapiens) 		no annotation 5 GLY A 156
ASN A 167
ASP A 169
ILE A 153
VAL A 144
 None
 1.19A 4dx5B-5yy8A:
undetectable		 4dx5B-5yy8A:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)

(Escherichia
coli) 		no annotation 5 SER A 217
GLN A 144
PHE A  62
ILE A 202
ALA A 173
 None
 1.02A 4dx5B-6d5iA:
undetectable		 4dx5B-6d5iA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ey4 GLDM

(Flavobacterium
johnsoniae) 		no annotation 6 GLY A 370
ASN A 354
ILE A 356
ALA A 358
VAL A 386
PHE A 348
 None
 1.43A 4dx5B-6ey4A:
4.8		 4dx5B-6ey4A:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gjt -

(-) 		no annotation 5 SER A 194
ASP A 168
ILE A 169
ALA A 171
VAL A 235
 None
 1.01A 4dx5B-6gjtA:
undetectable		 4dx5B-6gjtA:
undetectable