SIMILAR PATTERNS OF AMINO ACIDS FOR 4DVO_A_SORA404

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0c XYLOSE ISOMERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF01261
(AP_endonuc_2) 		6 HIS A 100
THR A 140
VAL A 185
ASN A 265
GLU A 267
ASP A 308
 None
None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 2.4A)
 1.36A 4dvoA-1a0cA:
39.7		 4dvoA-1a0cA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0c XYLOSE ISOMERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF01261
(AP_endonuc_2) 		6 THR A 140
TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 338
 None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.31A 4dvoA-1a0cA:
39.7		 4dvoA-1a0cA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0c XYLOSE ISOMERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF01261
(AP_endonuc_2) 		11 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
LYS A 233
ASN A 265
GLU A 267
HIS A 270
ASP A 295
ASP A 306
 None
None
None
None
None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 492 ( 1.9A)
 0.39A 4dvoA-1a0cA:
39.7		 4dvoA-1a0cA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0d XYLOSE ISOMERASE

(Geobacillus
stearothermophilus) 		PF01261
(AP_endonuc_2) 		6 HIS A  98
THR A 138
VAL A 183
ASN A 263
GLU A 265
ASP A 306
 None
None
None
None
MN  A 492 ( 2.3A)
MN  A 492 ( 2.8A)
 1.42A 4dvoA-1a0dA:
39.8		 4dvoA-1a0dA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0d XYLOSE ISOMERASE

(Geobacillus
stearothermophilus) 		PF01261
(AP_endonuc_2) 		5 THR A 138
TRP A 185
GLU A 265
HIS A 268
ASP A 336
 None
None
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.1A)
 1.29A 4dvoA-1a0dA:
39.8		 4dvoA-1a0dA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0d XYLOSE ISOMERASE

(Geobacillus
stearothermophilus) 		PF01261
(AP_endonuc_2) 		11 TRP A  47
HIS A  98
THR A 138
VAL A 183
TRP A 185
LYS A 231
ASN A 263
GLU A 265
HIS A 268
ASP A 293
ASP A 304
 None
None
None
None
None
MN  A 492 ( 4.8A)
None
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 492 ( 3.2A)
 0.44A 4dvoA-1a0dA:
39.8		 4dvoA-1a0dA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0e XYLOSE ISOMERASE

(Thermotoga
neapolitana) 		PF01261
(AP_endonuc_2) 		6 HIS A 100
THR A 140
VAL A 185
ASN A 265
GLU A 267
ASP A 308
 None
None
None
None
CO  A 492 ( 2.5A)
CO  A 492 (-3.3A)
 1.31A 4dvoA-1a0eA:
41.5		 4dvoA-1a0eA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0e XYLOSE ISOMERASE

(Thermotoga
neapolitana) 		PF01261
(AP_endonuc_2) 		6 THR A 140
TRP A 187
GLU A 267
HIS A 270
ASP A 338
ASP A 306
 None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.0A)
CO  A 492 (-4.3A)
 1.49A 4dvoA-1a0eA:
41.5		 4dvoA-1a0eA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0e XYLOSE ISOMERASE

(Thermotoga
neapolitana) 		PF01261
(AP_endonuc_2) 		11 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
LYS A 233
ASN A 265
GLU A 267
HIS A 270
ASP A 295
ASP A 306
 None
None
None
None
None
CO  A 492 ( 4.4A)
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 492 (-4.3A)
 0.61A 4dvoA-1a0eA:
41.5		 4dvoA-1a0eA:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bhw XYLOSE ISOMERASE

(Actinoplanes
missouriensis) 		PF01261
(AP_endonuc_2) 		8 HIS A  54
MET A  88
THR A  90
VAL A 135
ASN A 215
GLU A 217
ASP A 245
ASP A 257
 None
 1.28A 4dvoA-1bhwA:
57.6		 4dvoA-1bhwA:
66.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bhw XYLOSE ISOMERASE

(Actinoplanes
missouriensis) 		PF01261
(AP_endonuc_2) 		11 TRP A  16
HIS A  54
MET A  88
THR A  90
VAL A 135
TRP A 137
LYS A 183
ASN A 215
GLU A 217
ASP A 245
ASP A 255
 None
 0.27A 4dvoA-1bhwA:
57.6		 4dvoA-1bhwA:
66.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		6 HIS A  53
THR A  89
TRP A 136
GLU A 216
HIS A 219
ASP A 286
 None
 1.43A 4dvoA-1bxcA:
53.5		 4dvoA-1bxcA:
58.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		7 HIS A  53
THR A  89
VAL A 134
ASN A 214
GLU A 216
ASP A 244
ASP A 256
 None
 1.25A 4dvoA-1bxcA:
53.5		 4dvoA-1bxcA:
58.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		12 TRP A  15
HIS A  53
MET A  87
THR A  89
VAL A 134
TRP A 136
LYS A 182
ASN A 214
GLU A 216
HIS A 219
ASP A 244
ASP A 254
 None
 0.32A 4dvoA-1bxcA:
53.5		 4dvoA-1bxcA:
58.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1de6 L-RHAMNOSE ISOMERASE

(Escherichia
coli) 		PF06134
(RhaA) 		6 TRP A  48
HIS A 103
TRP A 193
LYS A 236
HIS A 270
ASP A 302
 RNS  A1462 ( 4.1A)
RNS  A1462 (-4.4A)
RNS  A1462 (-3.2A)
RNS  A1462 (-2.2A)
RNS  A1462 ( 3.5A)
MN  A 451 ( 2.2A)
 0.73A 4dvoA-1de6A:
27.3		 4dvoA-1de6A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1de6 L-RHAMNOSE ISOMERASE

(Escherichia
coli) 		PF06134
(RhaA) 		6 TRP A  48
TRP A 193
LYS A 236
ASN A 191
HIS A 270
ASP A 302
 RNS  A1462 ( 4.1A)
RNS  A1462 (-3.2A)
RNS  A1462 (-2.2A)
None
RNS  A1462 ( 3.5A)
MN  A 451 ( 2.2A)
 1.27A 4dvoA-1de6A:
27.3		 4dvoA-1de6A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4z BETA-AGARASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		5 MET A 144
THR A 115
ASN A 306
GLU A 189
ASP A 173
 None
None
None
EPE  A2002 (-3.0A)
EPE  A2002 (-3.5A)
 1.40A 4dvoA-1o4zA:
undetectable		 4dvoA-1o4zA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmx HYDROXYQUINOL
1,2-DIOXYGENASE

(Pimelobacter
simplex) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 MET A  89
THR A 106
VAL A 107
ASP A 249
ASP A 243
 None
 1.15A 4dvoA-1tmxA:
undetectable		 4dvoA-1tmxA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 THR A 220
ASN A 209
HIS A 295
ASP A 213
ASP A 418
 None
FE  A 502 ( 4.3A)
IND  A 503 (-3.5A)
None
None
 1.45A 4dvoA-2b24A:
undetectable		 4dvoA-2b24A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		7 TRP A  14
THR A  80
TRP A 126
LYS A 168
HIS A 204
ASP A 229
ASP A 238
 UNL  A 337 ( 3.9A)
UNL  A 337 ( 3.8A)
UNL  A 337 ( 3.7A)
UNL  A 337 ( 2.9A)
FE  A 333 (-3.3A)
FE  A 334 (-3.1A)
FE  A 333 (-1.9A)
 0.63A 4dvoA-3ktcA:
36.6		 4dvoA-3ktcA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p14 L-RHAMNOSE ISOMERASE

(Bacillus
halodurans) 		PF06134
(RhaA) 		6 TRP A  38
HIS A  93
TRP A 184
LYS A 227
HIS A 261
ASP A 293
 None
 0.78A 4dvoA-3p14A:
27.6		 4dvoA-3p14A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD

(Thermococcus
kodakarensis) 		PF01924
(HypD) 		5 HIS B 202
THR B 205
VAL B 259
ASN B 253
GLU B 254
 None
 1.34A 4dvoA-3vysB:
undetectable		 4dvoA-3vysB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gji L-RHAMNOSE ISOMERASE

(Pseudomonas
stutzeri) 		no annotation 5 TRP A  57
TRP A 179
LYS A 221
HIS A 257
ASP A 289
 RNS  A1001 (-3.5A)
RNS  A1001 (-3.3A)
RNS  A1001 (-2.7A)
MN  A1004 ( 3.4A)
MN  A1004 ( 2.6A)
 0.48A 4dvoA-4gjiA:
34.2		 4dvoA-4gjiA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Rattus
norvegicus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A1149
ASN A1101
GLU A1011
ASP A1010
ASP A1020
 None
 1.41A 4dvoA-4u14A:
undetectable		 4dvoA-4u14A:
21.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728) 		PF01261
(AP_endonuc_2) 		7 HIS A  53
THR A  89
VAL A 134
ASN A 214
GLU A 216
ASP A 244
ASP A 256
 SOR  A 400 (-4.0A)
SOR  A 400 (-3.3A)
SOR  A 400 (-4.5A)
None
MG  A 399 ( 2.8A)
MG  A 399 ( 3.1A)
None
 1.24A 4dvoA-4xiaA:
57.5		 4dvoA-4xiaA:
65.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728) 		PF01261
(AP_endonuc_2) 		5 THR A  89
TRP A 136
GLU A 216
HIS A 219
ASP A 292
 SOR  A 400 (-3.3A)
SOR  A 400 (-3.8A)
MG  A 399 ( 2.8A)
SOR  A 400 (-4.1A)
SOR  A 400 ( 2.7A)
 1.32A 4dvoA-4xiaA:
57.5		 4dvoA-4xiaA:
65.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728) 		PF01261
(AP_endonuc_2) 		5 THR A  89
TRP A 136
HIS A 219
ASP A 292
ASP A 254
 SOR  A 400 (-3.3A)
SOR  A 400 (-3.8A)
SOR  A 400 (-4.1A)
SOR  A 400 ( 2.7A)
SOR  A 400 ( 4.8A)
 1.33A 4dvoA-4xiaA:
57.5		 4dvoA-4xiaA:
65.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728) 		PF01261
(AP_endonuc_2) 		11 TRP A  15
HIS A  53
MET A  87
THR A  89
VAL A 134
TRP A 136
LYS A 182
ASN A 214
GLU A 216
HIS A 219
ASP A 244
 SOR  A 400 (-4.0A)
SOR  A 400 (-4.0A)
SOR  A 400 ( 4.4A)
SOR  A 400 (-3.3A)
SOR  A 400 (-4.5A)
SOR  A 400 (-3.8A)
SOR  A 400 (-2.9A)
None
MG  A 399 ( 2.8A)
SOR  A 400 (-4.1A)
MG  A 399 ( 3.1A)
 0.16A 4dvoA-4xiaA:
57.5		 4dvoA-4xiaA:
65.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728) 		PF01261
(AP_endonuc_2) 		10 TRP A  15
HIS A  53
MET A  87
THR A  89
VAL A 134
TRP A 136
LYS A 182
ASN A 214
HIS A 219
ASP A 254
 SOR  A 400 (-4.0A)
SOR  A 400 (-4.0A)
SOR  A 400 ( 4.4A)
SOR  A 400 (-3.3A)
SOR  A 400 (-4.5A)
SOR  A 400 (-3.8A)
SOR  A 400 (-2.9A)
None
SOR  A 400 (-4.1A)
SOR  A 400 ( 4.8A)
 0.67A 4dvoA-4xiaA:
57.5		 4dvoA-4xiaA:
65.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkm XYLOSE ISOMERASE

(Bacteroides
thetaiotaomicron) 		no annotation 6 HIS A 103
THR A 143
VAL A 188
ASN A 268
GLU A 270
ASP A 311
 None
None
None
None
MN  A 502 ( 2.5A)
MN  A 502 (-2.9A)
 1.45A 4dvoA-4xkmA:
40.0		 4dvoA-4xkmA:
28.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkm XYLOSE ISOMERASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 THR A 143
TRP A 190
GLU A 270
HIS A 273
ASP A 341
 None
None
MN  A 502 ( 2.5A)
MN  A 502 (-4.2A)
MN  A 501 (-3.1A)
 1.34A 4dvoA-4xkmA:
40.0		 4dvoA-4xkmA:
28.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkm XYLOSE ISOMERASE

(Bacteroides
thetaiotaomicron) 		no annotation 11 TRP A  51
HIS A 103
THR A 143
VAL A 188
TRP A 190
LYS A 236
ASN A 268
GLU A 270
HIS A 273
ASP A 298
ASP A 309
 None
None
None
None
None
None
None
MN  A 502 ( 2.5A)
MN  A 502 (-4.2A)
MN  A 501 (-3.2A)
MN  A 502 (-3.3A)
 0.48A 4dvoA-4xkmA:
40.0		 4dvoA-4xkmA:
28.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhb XYLOSE ISOMERASE

(Piromyces sp.
E2) 		no annotation 7 HIS A 102
THR A 142
VAL A 187
ASN A 267
GLU A 269
ASP A 297
ASP A 310
 None
None
None
None
FE2  A 502 ( 2.3A)
FE2  A 501 (-3.0A)
FE2  A 502 ( 3.9A)
 1.33A 4dvoA-5nhbA:
40.9		 4dvoA-5nhbA:
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhb XYLOSE ISOMERASE

(Piromyces sp.
E2) 		no annotation 5 THR A 142
TRP A 189
GLU A 269
HIS A 272
ASP A 340
 None
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 ( 3.2A)
 1.44A 4dvoA-5nhbA:
40.9		 4dvoA-5nhbA:
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhb XYLOSE ISOMERASE

(Piromyces sp.
E2) 		no annotation 11 TRP A  50
HIS A 102
THR A 142
VAL A 187
TRP A 189
LYS A 235
ASN A 267
GLU A 269
HIS A 272
ASP A 297
ASP A 308
 None
None
None
None
None
FE2  A 502 ( 4.1A)
None
FE2  A 502 ( 2.3A)
FE2  A 502 (-3.6A)
FE2  A 501 (-3.0A)
FE2  A 502 (-3.2A)
 0.47A 4dvoA-5nhbA:
40.9		 4dvoA-5nhbA:
29.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5y4j XYLOSE ISOMERASE

(Streptomyces
rubiginosus) 		PF01261
(AP_endonuc_2) 		7 HIS A  54
THR A  90
VAL A 135
ASN A 215
GLU A 217
ASP A 245
ASP A 257
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
None
MG  A 401 ( 2.8A)
MG  A 401 ( 3.0A)
None
 1.20A 4dvoA-5y4jA:
60.5		 4dvoA-5y4jA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5y4j XYLOSE ISOMERASE

(Streptomyces
rubiginosus) 		PF01261
(AP_endonuc_2) 		6 MET A  88
THR A  90
TRP A 137
GLU A 217
HIS A 220
ASP A 287
 None
XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
 1.39A 4dvoA-5y4jA:
60.5		 4dvoA-5y4jA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5y4j XYLOSE ISOMERASE

(Streptomyces
rubiginosus) 		PF01261
(AP_endonuc_2) 		6 MET A  88
THR A  90
TRP A 137
HIS A 220
ASP A 287
ASP A 255
 None
XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
XYL  A 402 ( 4.9A)
 1.45A 4dvoA-5y4jA:
60.5		 4dvoA-5y4jA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5y4j XYLOSE ISOMERASE

(Streptomyces
rubiginosus) 		PF01261
(AP_endonuc_2) 		11 TRP A  16
HIS A  54
MET A  88
THR A  90
VAL A 135
TRP A 137
LYS A 183
ASN A 215
GLU A 217
HIS A 220
ASP A 245
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
None
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 (-2.8A)
None
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
 0.22A 4dvoA-5y4jA:
60.5		 4dvoA-5y4jA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5y4j XYLOSE ISOMERASE

(Streptomyces
rubiginosus) 		PF01261
(AP_endonuc_2) 		10 TRP A  16
HIS A  54
MET A  88
THR A  90
VAL A 135
TRP A 137
LYS A 183
ASN A 215
HIS A 220
ASP A 255
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
None
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 (-2.8A)
None
XYL  A 402 (-4.2A)
XYL  A 402 ( 4.9A)
 0.68A 4dvoA-5y4jA:
60.5		 4dvoA-5y4jA:
99.74