SIMILAR PATTERNS OF AMINO ACIDS FOR 4DV7_A_SRYA1601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1je5 HELIX-DESTABILIZING
PROTEIN

(Escherichia
virus T7) 		no annotation 3 LYS A 169
PRO A  95
LYS A 109
 None
 1.35A 4dv7L-1je5A:
2.0		 4dv7L-1je5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1d D-HYDANTOINASE

(Geobacillus
stearothermophilus) 		PF01979
(Amidohydro_1) 		3 LYS A 277
PRO A 278
LYS A 284
 None
 1.42A 4dv7L-1k1dA:
0.0		 4dv7L-1k1dA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		3 LYS A  75
PRO A  70
LYS A   4
 None
 1.36A 4dv7L-1l1lA:
undetectable		 4dv7L-1l1lA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odt CEPHALOSPORIN C
DEACETYLASE

(Bacillus
subtilis) 		PF05448
(AXE1) 		3 LYS C 243
PRO C  21
LYS C 145
 None
 1.46A 4dv7L-1odtC:
0.0		 4dv7L-1odtC:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ska 3-PHYTASE A

(Aspergillus
fumigatus) 		PF00328
(His_Phos_2) 		3 LYS A 222
PRO A 225
LYS A  87
 None
 1.45A 4dv7L-1skaA:
0.0		 4dv7L-1skaA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc8 LYSINE BIOSYNTHESIS
ENZYME

(Thermus
thermophilus) 		PF08443
(RimK) 		3 LYS A 129
PRO A 130
LYS A  89
 None
 1.48A 4dv7L-1uc8A:
0.0		 4dv7L-1uc8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud9 DNA POLYMERASE
SLIDING CLAMP A

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 LYS A 222
PRO A 223
LYS A 126
 None
 1.33A 4dv7L-1ud9A:
0.3		 4dv7L-1ud9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE

(Thermotoga
maritima) 		PF02547
(Queuosine_synth) 		3 LYS A  76
PRO A  97
LYS A  72
 None
 1.35A 4dv7L-1vkyA:
0.5		 4dv7L-1vkyA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		3 LYS A 362
PRO A 385
LYS A 355
 None
 1.37A 4dv7L-1wacA:
0.0		 4dv7L-1wacA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 LYS A 353
PRO A 355
LYS A 311
 None
 1.05A 4dv7L-1we5A:
undetectable		 4dv7L-1we5A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ev8 55 KDA ERYTHROCYTE
MEMBRANE PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		3 LYS A  76
PRO A  81
LYS A 138
 None
 1.27A 4dv7L-2ev8A:
undetectable		 4dv7L-2ev8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i00 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 LYS A 141
PRO A 325
LYS A 110
 None
 1.38A 4dv7L-2i00A:
undetectable		 4dv7L-2i00A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i76 HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF10728
(DUF2520) 		3 LYS A  52
PRO A  54
LYS A  46
 None
 1.34A 4dv7L-2i76A:
undetectable		 4dv7L-2i76A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o13 MUSCLE LIM PROTEIN

(Homo sapiens) 		PF00412
(LIM) 		3 LYS A 119
PRO A 121
LYS A 138
 None
 1.27A 4dv7L-2o13A:
undetectable		 4dv7L-2o13A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox4 PUTATIVE MANDELATE
RACEMASE

(Zymomonas
mobilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LYS A 114
PRO A 111
LYS A 119
 None
 1.37A 4dv7L-2ox4A:
undetectable		 4dv7L-2ox4A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n SKP1-LIKE PROTEIN 1A

(Arabidopsis
thaliana) 		PF01466
(Skp1)
PF03931
(Skp1_POZ) 		3 LYS A   9
PRO A  43
LYS A  40
 None
 1.35A 4dv7L-2p1nA:
undetectable		 4dv7L-2p1nA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvp D-ALANINE-D-ALANINE
LIGASE

(Helicobacter
pylori) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 LYS A 171
PRO A 172
LYS A 130
 None
 1.41A 4dv7L-2pvpA:
undetectable		 4dv7L-2pvpA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q87 CMRF35-H ANTIGEN

(Homo sapiens) 		PF07686
(V-set) 		3 LYS A  48
PRO A  91
LYS A  30
 None
 1.38A 4dv7L-2q87A:
undetectable		 4dv7L-2q87A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2re3 UNCHARACTERIZED
PROTEIN

(Ruegeria
pomeroyi) 		PF06938
(DUF1285) 		3 LYS A  85
PRO A  34
LYS A  71
 None
 1.30A 4dv7L-2re3A:
undetectable		 4dv7L-2re3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adc L-SERYL-TRNA(SEC)
KINASE

(Methanocaldococcus
jannaschii) 		PF08433
(KTI12) 		3 LYS A  95
PRO A 171
LYS A  -1
 None
 1.35A 4dv7L-3adcA:
undetectable		 4dv7L-3adcA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4r UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF06254
(YdaT_toxin) 		3 LYS A  72
PRO A  40
LYS A  57
 None
 1.26A 4dv7L-3c4rA:
undetectable		 4dv7L-3c4rA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9w TALIN-2

(Mus musculus) 		PF00373
(FERM_M)
PF02174
(IRS) 		3 LYS A 319
PRO A 330
LYS A 327
 None
 1.37A 4dv7L-3g9wA:
undetectable		 4dv7L-3g9wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		3 LYS A 553
PRO A 556
LYS A 560
 None
 1.22A 4dv7L-3poyA:
undetectable		 4dv7L-3poyA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137

(Staphylococcus
aureus) 		PF13379
(NMT1_2) 		3 LYS A 101
PRO A 307
LYS A 108
 None
 1.19A 4dv7L-3un6A:
undetectable		 4dv7L-3un6A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 LYS P 461
PRO P 464
LYS P 416
 None
 1.29A 4dv7L-4crnP:
2.2		 4dv7L-4crnP:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 LYS A 247
PRO A 248
LYS A 285
 None
 1.49A 4dv7L-4i3gA:
undetectable		 4dv7L-4i3gA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9u L-LACTATE
DEHYDROGENASE A
CHAIN

(Oryctolagus
cuniculus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LYS A  21
PRO A  18
LYS A  75
 None
 1.41A 4dv7L-4i9uA:
undetectable		 4dv7L-4i9uA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ina SACCHAROPINE
DEHYDROGENASE

(Wolinella
succinogenes) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 LYS A 362
PRO A 378
LYS A 356
 None
 1.47A 4dv7L-4inaA:
undetectable		 4dv7L-4inaA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 LYS A  45
PRO A  46
LYS A  80
 None
 1.35A 4dv7L-4qk3A:
undetectable		 4dv7L-4qk3A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9s RRNA BIOGENESIS
PROTEIN RRP5

(Saccharomyces
cerevisiae) 		no annotation 3 LYS B1650
PRO B1649
LYS B1682
 None
 1.17A 4dv7L-5c9sB:
undetectable		 4dv7L-5c9sB:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd2 ENDO-1,4-D-GLUCANASE

(Aliivibrio
fischeri) 		PF01270
(Glyco_hydro_8) 		3 LYS A 238
PRO A 292
LYS A 313
 None
 1.28A 4dv7L-5cd2A:
undetectable		 4dv7L-5cd2A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum) 		no annotation 3 LYS B 398
PRO B 399
LYS B 421
 None
 1.45A 4dv7L-5cwwB:
undetectable		 4dv7L-5cwwB:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msn DCC1 PROTEIN

(Saccharomyces
cerevisiae) 		PF09724
(Dcc1) 		3 LYS A 326
PRO A 325
LYS A 364
 None
 1.11A 4dv7L-5msnA:
undetectable		 4dv7L-5msnA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oes GLUTATHIONE
SYNTHETASE

(Solanum
tuberosum) 		no annotation 3 LYS A 372
PRO A 373
LYS A 318
 ADP  A 501 (-2.9A)
None
ADP  A 501 (-3.9A)
 1.44A 4dv7L-5oesA:
undetectable		 4dv7L-5oesA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 3 LYS A  66
PRO A  69
LYS A 167
 None
 1.19A 4dv7L-5opqA:
undetectable		 4dv7L-5opqA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfr 26S PROTEASOME
REGULATORY SUBUNIT
6B
PROTEASOME SUBUNIT
ALPHA TYPE-2

(Homo sapiens) 		no annotation 3 LYS H 165
PRO H  34
LYS D 418
 None
 1.44A 4dv7L-5vfrH:
undetectable		 4dv7L-5vfrH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 3 LYS A 180
PRO A 244
LYS A 296
 None
 1.12A 4dv7L-6a8mA:
undetectable		 4dv7L-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT C'
V-TYPE PROTON ATPASE
SUBUNIT D

(Saccharomyces
cerevisiae) 		no annotation 3 LYS B   2
PRO B 203
LYS D  40
 None
 0.89A 4dv7L-6c6lB:
undetectable		 4dv7L-6c6lB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A1057
PRO A1061
LYS A1054
 None
 1.03A 4dv7L-6emkA:
undetectable		 4dv7L-6emkA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 3 LYS A  93
PRO A  96
LYS A 103
 None
 1.45A 4dv7L-6eroA:
undetectable		 4dv7L-6eroA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 3 LYS A 103
PRO A 105
LYS A  93
 None
 1.46A 4dv7L-6eroA:
undetectable		 4dv7L-6eroA:
18.42