SIMILAR PATTERNS OF AMINO ACIDS FOR 4DV1_A_SRYA1601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad9 IGG CTM01 FAB (LIGHT
CHAIN)

(Homo sapiens) 		no annotation 3 LYS L  42
LYS L  39
PRO L  40
 None
 1.11A 4dv1L-1ad9L:
0.5		 4dv1L-1ad9L:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dow ALPHA-CATENIN

(Mus musculus) 		PF01044
(Vinculin) 		3 LYS A 178
LYS A 181
PRO A 182
 None
 0.97A 4dv1L-1dowA:
undetectable		 4dv1L-1dowA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhe GLUTATHIONE
TRANSFERASE

(Fasciola
hepatica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 LYS A 130
LYS A 127
PRO A 126
 None
 1.16A 4dv1L-1fheA:
0.0		 4dv1L-1fheA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fho UNC-89

(Caenorhabditis
elegans) 		no annotation 3 LYS A  91
LYS A  89
PRO A  90
 None
 1.28A 4dv1L-1fhoA:
0.0		 4dv1L-1fhoA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1if1 PROTEIN (INTERFERON
REGULATORY FACTOR 1)

(Mus musculus) 		PF00605
(IRF) 		3 LYS A  78
LYS A  75
PRO A  74
 None
 0.92A 4dv1L-1if1A:
0.0		 4dv1L-1if1A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lry PEPTIDE DEFORMYLASE

(Pseudomonas
aeruginosa) 		PF01327
(Pep_deformylase) 		3 LYS A  55
LYS A  18
PRO A  19
 None
 1.28A 4dv1L-1lryA:
0.1		 4dv1L-1lryA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		3 LYS A 437
LYS A 434
PRO A 435
 None
 1.05A 4dv1L-1lwhA:
0.0		 4dv1L-1lwhA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		3 LYS A  16
LYS A  13
PRO A  14
 None
 1.24A 4dv1L-1mu2A:
0.0		 4dv1L-1mu2A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		3 LYS B  16
LYS B  13
PRO B  14
 None
 0.89A 4dv1L-1mu2B:
0.0		 4dv1L-1mu2B:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 LYS A1106
LYS A1105
PRO A1109
 None
 1.17A 4dv1L-1n5xA:
0.0		 4dv1L-1n5xA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odu PUTATIVE
ALPHA-L-FUCOSIDASE

(Thermotoga
maritima) 		PF01120
(Alpha_L_fucos) 		3 LYS A 317
LYS A 274
PRO A 276
 None
 1.10A 4dv1L-1oduA:
undetectable		 4dv1L-1oduA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p33 PTERIDINE REDUCTASE
1

(Leishmania
tarentolae) 		PF13561
(adh_short_C2) 		3 LYS A 270
LYS A 268
PRO A 267
 None
 1.27A 4dv1L-1p33A:
undetectable		 4dv1L-1p33A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p6f NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
1

(Homo sapiens) 		no annotation 3 LYS A  20
LYS A  22
PRO A  19
 None
 1.29A 4dv1L-1p6fA:
undetectable		 4dv1L-1p6fA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys) 		PF01593
(Amino_oxidase) 		3 LYS A 311
LYS A 312
PRO A 309
 None
 0.95A 4dv1L-1tdkA:
undetectable		 4dv1L-1tdkA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwx ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS K  44
LYS K  41
PRO K  42
 None
 1.18A 4dv1L-1uwxK:
undetectable		 4dv1L-1uwxK:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcn CTP SYNTHETASE

(Thermus
thermophilus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		3 LYS A 198
LYS A 200
PRO A 201
 SO4  A 630 (-2.9A)
SO4  A 630 (-4.0A)
None
 1.18A 4dv1L-1vcnA:
undetectable		 4dv1L-1vcnA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		3 LYS A  85
LYS A  84
PRO A  88
 SO4  A1396 ( 4.0A)
SO4  A1396 (-2.7A)
None
 1.28A 4dv1L-1wb0A:
undetectable		 4dv1L-1wb0A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8m CONSERVED
HYPOTHETICAL PROTEIN
HP0894

(Helicobacter
pylori) 		PF15738
(YafQ_toxin) 		3 LYS A  52
LYS A  54
PRO A  55
 None
 0.94A 4dv1L-1z8mA:
undetectable		 4dv1L-1z8mA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ao7 ADAM 10

(Bos taurus) 		PF00200
(Disintegrin) 		3 LYS A 501
LYS A 498
PRO A 499
 None
 1.25A 4dv1L-2ao7A:
undetectable		 4dv1L-2ao7A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6g VTS1P

(Saccharomyces
cerevisiae) 		PF07647
(SAM_2) 		3 LYS A 454
LYS A 451
PRO A 450
 None
 0.94A 4dv1L-2b6gA:
undetectable		 4dv1L-2b6gA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dat POSSIBLE GLOBAL
TRANSCRIPTION
ACTIVATOR SNF2L2

(Homo sapiens) 		PF00439
(Bromodomain) 		3 LYS A  16
LYS A  13
PRO A  12
 None
 1.11A 4dv1L-2datA:
undetectable		 4dv1L-2datA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddt SPHINGOMYELIN
PHOSPHODIESTERASE

(Bacillus cereus) 		PF03372
(Exo_endo_phos) 		3 LYS A  69
LYS A  68
PRO A  72
 None
 0.91A 4dv1L-2ddtA:
undetectable		 4dv1L-2ddtA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eqz HIGH MOBILITY GROUP
PROTEIN B3

(Homo sapiens) 		PF09011
(HMG_box_2) 		3 LYS A  36
LYS A  35
PRO A  39
 None
 1.05A 4dv1L-2eqzA:
undetectable		 4dv1L-2eqzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gie TYPE II RESTRICTION
ENZYME HINCII

(Haemophilus
influenzae) 		PF09226
(Endonuc-HincII) 		3 LYS A   2
LYS A   5
PRO A   6
 None
 1.22A 4dv1L-2gieA:
undetectable		 4dv1L-2gieA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1r DIMETHYLADENOSINE
TRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00398
(RrnaAD) 		3 LYS A 236
LYS A 237
PRO A 234
 None
 1.02A 4dv1L-2h1rA:
undetectable		 4dv1L-2h1rA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350

(Human
gammaherpesvirus
4) 		PF05109
(Herpes_BLLF1) 		3 LYS A 110
LYS A 109
PRO A 154
 None
 1.16A 4dv1L-2h6oA:
undetectable		 4dv1L-2h6oA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i53 CYCLIN K

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		3 LYS A 112
LYS A 111
PRO A 110
 None
 1.05A 4dv1L-2i53A:
undetectable		 4dv1L-2i53A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mcq UNCHARACTERIZED
PROTEIN RP812

(Rickettsia
prowazekii) 		PF01722
(BolA) 		3 LYS A  14
LYS A  13
PRO A  17
 None
 1.14A 4dv1L-2mcqA:
undetectable		 4dv1L-2mcqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n2u OR358

(synthetic
construct) 		no annotation 3 LYS A  56
LYS A  55
PRO A  59
 None
 1.24A 4dv1L-2n2uA:
undetectable		 4dv1L-2n2uA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzq AXIN INTERACTOR,
DORSALIZATION
ASSOCIATED PROTEIN

(Danio rerio) 		PF14186
(Aida_C2) 		3 LYS A 142
LYS A 143
PRO A 144
 None
 1.26A 4dv1L-2qzqA:
undetectable		 4dv1L-2qzqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		3 LYS A 903
LYS A 904
PRO A 901
 None
 0.98A 4dv1L-2wfhA:
undetectable		 4dv1L-2wfhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a01 HOMEODOMAIN-CONTAINI
NG PROTEIN

(Drosophila
melanogaster) 		PF00046
(Homeobox) 		3 LYS A 186
LYS A 187
PRO A 188
 None
 1.28A 4dv1L-3a01A:
undetectable		 4dv1L-3a01A:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjq PHAGE-RELATED
PROTEIN

(Bordetella
bronchiseptica) 		PF03864
(Phage_cap_E) 		3 LYS A  32
LYS A  31
PRO A  35
 None
PG4  A 316 (-2.9A)
None
 1.12A 4dv1L-3bjqA:
undetectable		 4dv1L-3bjqA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn0 30S RIBOSOMAL
PROTEIN S16

(Aquifex
aeolicus) 		PF00886
(Ribosomal_S16) 		3 LYS A  45
LYS A  43
PRO A  42
 None
None
GOL  A 200 ( 4.9A)
 1.24A 4dv1L-3bn0A:
undetectable		 4dv1L-3bn0A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 LYS C 151
LYS C 170
PRO C 171
 None
 1.26A 4dv1L-3bvhC:
undetectable		 4dv1L-3bvhC:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		3 LYS A 192
LYS A 189
PRO A 190
 None
 1.28A 4dv1L-3c9bA:
undetectable		 4dv1L-3c9bA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 LYS A 972
LYS A 973
PRO A 970
 None
 1.20A 4dv1L-3cmmA:
undetectable		 4dv1L-3cmmA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA

(Lactococcus
lactis) 		PF00496
(SBP_bac_5) 		3 LYS A 217
LYS A 213
PRO A 212
 None
 0.79A 4dv1L-3drkA:
undetectable		 4dv1L-3drkA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dvf AMYLOIDOGENIC
IMMUNOGLOBULIN LIGHT
CHAIN PROTEIN AL-12

(Homo sapiens) 		PF07686
(V-set) 		3 LYS A  42
LYS A  39
PRO A  40
 None
 1.06A 4dv1L-3dvfA:
undetectable		 4dv1L-3dvfA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		3 LYS A 296
LYS A 297
PRO A 294
 None
 1.20A 4dv1L-3f41A:
undetectable		 4dv1L-3f41A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD

(Bacillus
anthracis) 		no annotation 3 LYS L 326
LYS L 322
PRO L 324
 None
 1.11A 4dv1L-3g9kL:
undetectable		 4dv1L-3g9kL:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggy INCREASED SODIUM
TOLERANCE PROTEIN 1

(Saccharomyces
cerevisiae) 		PF03398
(Ist1) 		3 LYS A 158
LYS A 157
PRO A 161
 None
 1.23A 4dv1L-3ggyA:
undetectable		 4dv1L-3ggyA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpr RHODOCETIN SUBUNIT
GAMMA

(Calloselasma
rhodostoma) 		PF00059
(Lectin_C) 		3 LYS C3124
LYS C3023
PRO C3022
 None
 1.15A 4dv1L-3gprC:
undetectable		 4dv1L-3gprC:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 LYS A 575
LYS A 573
PRO A 574
 None
 1.25A 4dv1L-3h0gA:
undetectable		 4dv1L-3h0gA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k10 PROTEIN STN1

(Saccharomyces
cerevisiae) 		PF12659
(Stn1_C) 		3 LYS A 457
LYS A 456
PRO A 460
 None
 0.94A 4dv1L-3k10A:
undetectable		 4dv1L-3k10A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7d GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		3 LYS A 872
LYS A 870
PRO A 871
 None
 1.18A 4dv1L-3k7dA:
undetectable		 4dv1L-3k7dA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		3 LYS A 311
LYS A 312
PRO A 309
 None
 1.07A 4dv1L-3kveA:
undetectable		 4dv1L-3kveA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Staphylococcus
aureus) 		PF00724
(Oxidored_FMN) 		3 LYS A   1
LYS A   5
PRO A   6
 None
 1.26A 4dv1L-3l5aA:
undetectable		 4dv1L-3l5aA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 LYS A 451
LYS A 482
PRO A 483
 None
PEG  A 643 (-2.6A)
None
 1.24A 4dv1L-3lk6A:
undetectable		 4dv1L-3lk6A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oe7 ATP SYNTHASE SUBUNIT
GAMMA

(Saccharomyces
cerevisiae) 		PF00231
(ATP-synt) 		3 LYS G 161
LYS G  71
PRO G 160
 None
 1.15A 4dv1L-3oe7G:
undetectable		 4dv1L-3oe7G:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9p MONOCLONAL FAB
FRAGMENT LIGHT CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS L  42
LYS L  39
PRO L  40
 None
 1.15A 4dv1L-3u9pL:
undetectable		 4dv1L-3u9pL:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 LYS A  84
LYS A  81
PRO A  80
 None
 1.24A 4dv1L-3v8uA:
undetectable		 4dv1L-3v8uA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vg8 HYPOTHETICAL PROTEIN
TTHB210

(Thermus
thermophilus) 		no annotation 3 LYS G  52
LYS G  53
PRO G  50
 None
 1.08A 4dv1L-3vg8G:
undetectable		 4dv1L-3vg8G:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5

(Homo sapiens) 		PF07719
(TPR_2)
PF13181
(TPR_8)
PF13374
(TPR_10)
PF13424
(TPR_12) 		3 LYS A 313
LYS A 309
PRO A 308
 None
 1.24A 4dv1L-3zgqA:
undetectable		 4dv1L-3zgqA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1e ALPHA-ACTININ-2

(Homo sapiens) 		PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen) 		3 LYS A 205
LYS A 182
PRO A 208
 None
MLZ  A 181 ( 3.1A)
MLZ  A 181 ( 4.8A)
 1.26A 4dv1L-4d1eA:
undetectable		 4dv1L-4d1eA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ge0 UNCHARACTERIZED
PROTEIN C22E12.03C

(Schizosaccharomyces
pombe) 		PF01965
(DJ-1_PfpI) 		3 LYS A 105
LYS A 102
PRO A 103
 None
 1.16A 4dv1L-4ge0A:
undetectable		 4dv1L-4ge0A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LYS C 224
LYS C 223
PRO C 227
 None
 1.24A 4dv1L-4gypC:
undetectable		 4dv1L-4gypC:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyr GLUCARATE
DEHYDRATASE

(Acidaminococcus
intestini) 		PF13378
(MR_MLE_C) 		3 LYS A 221
LYS A 220
PRO A 224
 None
 1.00A 4dv1L-4hyrA:
undetectable		 4dv1L-4hyrA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kb3 PEROXIDOXIN

(Leishmania
braziliensis) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		3 LYS A 122
LYS A 123
PRO A 120
 None
 1.15A 4dv1L-4kb3A:
undetectable		 4dv1L-4kb3A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krr WNT INHIBITOR OF
DORSAL PROTEIN

(Drosophila
melanogaster) 		PF00110
(wnt) 		3 LYS A  70
LYS A  73
PRO A  74
 None
 1.19A 4dv1L-4krrA:
undetectable		 4dv1L-4krrA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyp EXO-BETA-1,4-MANNOSI
DASE

(Rhizomucor
miehei) 		no annotation 3 LYS A 220
LYS A 219
PRO A 223
 None
 1.22A 4dv1L-4lypA:
undetectable		 4dv1L-4lypA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnu TRANSCRIPTION FACTOR
A, MITOCHONDRIAL

(Homo sapiens) 		PF00505
(HMG_box)
PF09011
(HMG_box_2) 		3 LYS A  52
LYS A  51
PRO A  50
 None
 1.06A 4dv1L-4nnuA:
undetectable		 4dv1L-4nnuA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nt1 ACCELERATED-CELL-DEA
TH 11

(Arabidopsis
thaliana) 		PF08718
(GLTP) 		3 LYS A 169
LYS A   7
PRO A   9
 None
 1.01A 4dv1L-4nt1A:
undetectable		 4dv1L-4nt1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA

(Staphylococcus
pseudintermedius) 		PF01297
(ZnuA) 		3 LYS A  71
LYS A  69
PRO A  70
 None
 1.25A 4dv1L-4oxrA:
undetectable		 4dv1L-4oxrA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF04551
(GcpE) 		3 LYS A 382
LYS A 368
PRO A 367
 None
 0.99A 4dv1L-4s38A:
undetectable		 4dv1L-4s38A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trk C. ELEGANS HIM-3

(Caenorhabditis
elegans) 		PF02301
(HORMA) 		3 LYS A 110
LYS A 111
PRO A 112
 None
 1.19A 4dv1L-4trkA:
undetectable		 4dv1L-4trkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoo LIPOTEICHOIC ACID
SYNTHASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		3 LYS A 393
LYS A 395
PRO A 396
 None
 1.16A 4dv1L-4uooA:
undetectable		 4dv1L-4uooA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		3 LYS A 406
LYS A 440
PRO A 441
 None
 1.01A 4dv1L-4wxxA:
undetectable		 4dv1L-4wxxA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 LYS A 359
LYS A 397
PRO A 398
 None
 1.06A 4dv1L-4zktA:
undetectable		 4dv1L-4zktA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr7 SENSOR HISTIDINE
KINASE RESE

(Bacillus
subtilis) 		no annotation 3 LYS A 122
LYS A 121
PRO A 144
 None
 1.13A 4dv1L-4zr7A:
undetectable		 4dv1L-4zr7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 LYS A 368
LYS A 367
PRO A  50
 None
 1.21A 4dv1L-5a1iA:
undetectable		 4dv1L-5a1iA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5caj UPF0246 PROTEIN YAAA

(Escherichia
coli) 		PF03883
(H2O2_YaaD) 		3 LYS A 182
LYS A 180
PRO A 181
 None
 1.08A 4dv1L-5cajA:
undetectable		 4dv1L-5cajA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 LYS A 159
LYS A 158
PRO A 162
 None
 1.17A 4dv1L-5dllA:
undetectable		 4dv1L-5dllA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f72 SINGLE CHAIN FV FROM
A FAB

(Homo sapiens) 		no annotation 3 LYS T 183
LYS T 180
PRO T 181
 None
 1.19A 4dv1L-5f72T:
undetectable		 4dv1L-5f72T:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpl PUTATIVE NUCLEOSOME
ASSEMBLY PROTEIN
C36B7.08C

(Schizosaccharomyces
pombe) 		PF00956
(NAP) 		3 LYS A 148
LYS A 145
PRO A 146
 None
 0.91A 4dv1L-5gplA:
undetectable		 4dv1L-5gplA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs3 DIABODY PROTEIN

(Homo sapiens) 		no annotation 3 LYS H 166
LYS H 163
PRO H 164
 None
 1.21A 4dv1L-5gs3H:
undetectable		 4dv1L-5gs3H:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtk BETAINE-ALDEHYDE
DEHYDROGENASE

(Bacillus cereus) 		PF00171
(Aldedh) 		3 LYS A  11
LYS A   9
PRO A  10
 None
 1.00A 4dv1L-5gtkA:
undetectable		 4dv1L-5gtkA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		3 LYS h 110
LYS h 113
PRO h 114
 None
 1.28A 4dv1L-5gw5h:
undetectable		 4dv1L-5gw5h:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1f UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		3 LYS A 213
LYS A 211
PRO A 212
 None
None
CL  A 306 (-3.6A)
 1.24A 4dv1L-5i1fA:
undetectable		 4dv1L-5i1fA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 30S RIBOSOMAL
PROTEIN S27E

(Pyrococcus
abyssi) 		PF01667
(Ribosomal_S27e) 		3 LYS W   1
LYS W   3
PRO W   4
 None
G  2 608 ( 4.0A)
None
 1.03A 4dv1L-5jb3W:
undetectable		 4dv1L-5jb3W:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		3 LYS A 300
LYS A 301
PRO A 298
 None
 1.11A 4dv1L-5laeA:
undetectable		 4dv1L-5laeA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		3 LYS A 974
LYS A 972
PRO A 973
 None
 1.18A 4dv1L-5me3A:
undetectable		 4dv1L-5me3A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mj3 INTERLEUKIN-12
SUBUNIT BETA

(Homo sapiens) 		PF10420
(IL12p40_C) 		3 LYS A 134
LYS A 234
PRO A 235
 None
 1.28A 4dv1L-5mj3A:
undetectable		 4dv1L-5mj3A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms3 KALLIKREIN-8

(Homo sapiens) 		no annotation 3 LYS A 166
LYS A 167
PRO A 164
 None
 1.14A 4dv1L-5ms3A:
undetectable		 4dv1L-5ms3A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 LYS A 502
LYS A 499
PRO A 500
 None
 1.19A 4dv1L-5t98A:
undetectable		 4dv1L-5t98A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		3 LYS A 193
LYS A 195
PRO A 196
 None
 0.91A 4dv1L-5u03A:
undetectable		 4dv1L-5u03A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uib OXIDOREDUCTASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF01408
(GFO_IDH_MocA) 		3 LYS A  44
LYS A  41
PRO A  40
 None
 1.05A 4dv1L-5uibA:
undetectable		 4dv1L-5uibA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqz GLUCAN-BINDING
PROTEIN C, GBPC

(Streptococcus
mutans) 		no annotation 3 LYS A 196
LYS A 242
PRO A 241
 None
 1.09A 4dv1L-5uqzA:
undetectable		 4dv1L-5uqzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 LYS A 758
LYS A 757
PRO A 565
 None
 1.23A 4dv1L-5vniA:
undetectable		 4dv1L-5vniA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		no annotation 3 LYS C 406
LYS C 440
PRO C 441
 None
 1.09A 4dv1L-5wvoC:
undetectable		 4dv1L-5wvoC:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1

(Homo sapiens) 		PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3) 		3 LYS A 373
LYS A 376
PRO A 377
 None
 1.25A 4dv1L-5xjyA:
undetectable		 4dv1L-5xjyA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xym 50S RIBOSOMAL
PROTEIN L33 2

(Mycolicibacterium
smegmatis) 		PF00471
(Ribosomal_L33) 		3 LYS 1  26
LYS 1   6
PRO 1   8
 None
 1.26A 4dv1L-5xym1:
undetectable		 4dv1L-5xym1:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ylv POTASSIUM-TRANSPORTI
NG ATPASE SUBUNIT
BETA

(Sus scrofa) 		no annotation 3 LYS B 235
LYS B 234
PRO B 238
 None
 1.17A 4dv1L-5ylvB:
undetectable		 4dv1L-5ylvB:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC

(Zea mays) 		no annotation 3 LYS 1 166
LYS 1 165
PRO 1 169
 None
None
CLA  1 610 (-3.3A)
 1.08A 4dv1L-5zji1:
undetectable		 4dv1L-5zji1:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bb4 MOUSE MONOCLONAL
ANTIBODY C5.2 FAB
LIGHT CHAIN

(Mus musculus) 		no annotation 3 LYS L  42
LYS L  39
PRO L  40
 None
 1.11A 4dv1L-6bb4L:
undetectable		 4dv1L-6bb4L:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT SWP1

(Saccharomyces
cerevisiae) 		no annotation 3 LYS C 147
LYS C 145
PRO C 146
 None
 1.08A 4dv1L-6c26C:
undetectable		 4dv1L-6c26C:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6y JC57-14 LIGHT CHAIN

(Macaca mulatta) 		no annotation 3 LYS B  42
LYS B  39
PRO B  40
 None
SO4  B 301 (-4.0A)
None
 1.05A 4dv1L-6c6yB:
undetectable		 4dv1L-6c6yB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es4 SYNCRIP, ISOFORM K

(Drosophila
melanogaster) 		no annotation 3 LYS A 234
LYS A 231
PRO A 232
 SO4  A 303 (-3.0A)
None
None
 1.05A 4dv1L-6es4A:
undetectable		 4dv1L-6es4A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4g PROBABLE U2 SMALL
NUCLEAR
RIBONUCLEOPROTEIN A'

(Drosophila
melanogaster) 		no annotation 3 LYS A   3
LYS A   1
PRO A  32
 None
 1.13A 4dv1L-6f4gA:
undetectable		 4dv1L-6f4gA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gy6 -

(-) 		no annotation 3 LYS B 172
LYS B 169
PRO B 168
 None
 1.02A 4dv1L-6gy6B:
undetectable		 4dv1L-6gy6B:
undetectable