SIMILAR PATTERNS OF AMINO ACIDS FOR 4DUZ_A_SRYA1601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dot DUCK OVOTRANSFERRIN

(Anas
platyrhynchos) 		PF00405
(Transferrin) 		3 LYS A 296
PRO A 293
LYS A 290
 None
 1.49A 4duzL-1dotA:
0.0		 4duzL-1dotA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR

(Homo sapiens) 		PF00439
(Bromodomain) 		3 LYS A1534
PRO A1538
LYS A1419
 None
 1.48A 4duzL-1eqfA:
undetectable		 4duzL-1eqfA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		3 LYS A  75
PRO A  70
LYS A   4
 None
 1.40A 4duzL-1l1lA:
0.0		 4duzL-1l1lA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2f L-LACTATE
DEHYDROGENASE B
CHAIN

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LYS A  22
PRO A  19
LYS A  76
 None
 1.50A 4duzL-1t2fA:
0.0		 4duzL-1t2fA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE

(Thermotoga
maritima) 		PF02547
(Queuosine_synth) 		3 LYS A  76
PRO A  97
LYS A  72
 None
 1.12A 4duzL-1vkyA:
0.0		 4duzL-1vkyA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 LYS A 353
PRO A 355
LYS A 311
 None
 0.73A 4duzL-1we5A:
0.0		 4duzL-1we5A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7d ORNITHINE
AMINOTRANSFERASE

(Plasmodium
yoelii) 		PF00202
(Aminotran_3) 		3 LYS A 320
PRO A 324
LYS A 392
 None
 1.23A 4duzL-1z7dA:
0.6		 4duzL-1z7dA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bol SMALL HEAT SHOCK
PROTEIN

(Taenia saginata) 		PF00011
(HSP20) 		3 LYS A 251
PRO A 207
LYS A 196
 None
 1.44A 4duzL-2bolA:
0.0		 4duzL-2bolA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erv HYPOTHETICAL PROTEIN
PAER03002360

(Pseudomonas
aeruginosa) 		PF09411
(PagL) 		3 LYS A 147
PRO A 149
LYS A 113
 None
 1.50A 4duzL-2ervA:
0.0		 4duzL-2ervA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gks BIFUNCTIONAL SAT/APS
KINASE

(Aquifex
aeolicus) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 LYS A 370
PRO A 367
LYS A 545
 None
 1.27A 4duzL-2gksA:
0.0		 4duzL-2gksA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i00 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 LYS A 141
PRO A 325
LYS A 110
 None
 1.32A 4duzL-2i00A:
undetectable		 4duzL-2i00A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i76 HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF10728
(DUF2520) 		3 LYS A  52
PRO A  54
LYS A  46
 None
 1.49A 4duzL-2i76A:
undetectable		 4duzL-2i76A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j13 POLYSACCHARIDE
DEACETYLASE

(Bacillus
anthracis) 		PF01522
(Polysacc_deac_1) 		3 LYS A  45
PRO A 194
LYS A 221
 None
 1.50A 4duzL-2j13A:
undetectable		 4duzL-2j13A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o56 PUTATIVE MANDELATE
RACEMASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LYS A 118
PRO A 115
LYS A 123
 None
 1.46A 4duzL-2o56A:
undetectable		 4duzL-2o56A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvp D-ALANINE-D-ALANINE
LIGASE

(Helicobacter
pylori) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 LYS A 171
PRO A 172
LYS A 130
 None
 1.44A 4duzL-2pvpA:
undetectable		 4duzL-2pvpA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q87 CMRF35-H ANTIGEN

(Homo sapiens) 		PF07686
(V-set) 		3 LYS A  48
PRO A  91
LYS A  30
 None
 1.45A 4duzL-2q87A:
undetectable		 4duzL-2q87A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2re3 UNCHARACTERIZED
PROTEIN

(Ruegeria
pomeroyi) 		PF06938
(DUF1285) 		3 LYS A  85
PRO A  34
LYS A  71
 None
 1.36A 4duzL-2re3A:
undetectable		 4duzL-2re3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0x LAMINA-ASSOCIATED
POLYPEPTIDE 2
ISOFORMS ALPHA/ZETA

(Mus musculus) 		PF11560
(LAP2alpha) 		3 LYS A 664
PRO A 661
LYS A 658
 None
 1.01A 4duzL-2v0xA:
undetectable		 4duzL-2v0xA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adc L-SERYL-TRNA(SEC)
KINASE

(Methanocaldococcus
jannaschii) 		PF08433
(KTI12) 		3 LYS A  95
PRO A 171
LYS A  -1
 None
 1.25A 4duzL-3adcA:
undetectable		 4duzL-3adcA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4r UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF06254
(YdaT_toxin) 		3 LYS A  72
PRO A  40
LYS A  57
 None
 1.46A 4duzL-3c4rA:
undetectable		 4duzL-3c4rA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9j MEMBER OF DUF4221
FAMILY

(Bacteroides
vulgatus) 		PF13970
(DUF4221) 		3 LYS A 178
PRO A 179
LYS A 182
 None
 1.33A 4duzL-3s9jA:
undetectable		 4duzL-3s9jA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE

(Brevibacillus
brevis) 		PF03306
(AAL_decarboxy) 		3 LYS A 104
PRO A 101
LYS A 134
 None
 1.39A 4duzL-4bt6A:
undetectable		 4duzL-4bt6A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9u L-LACTATE
DEHYDROGENASE A
CHAIN

(Oryctolagus
cuniculus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LYS A  21
PRO A  18
LYS A  75
 None
 1.48A 4duzL-4i9uA:
undetectable		 4duzL-4i9uA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkv LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		3 LYS A 304
PRO A 302
LYS A 340
 None
 1.33A 4duzL-4pkvA:
undetectable		 4duzL-4pkvA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 LYS A  45
PRO A  46
LYS A  80
 None
 1.43A 4duzL-4qk3A:
undetectable		 4duzL-4qk3A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woe TAUROCYAMINE KINASE

(Schistosoma
mansoni) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 LYS A 646
PRO A 648
LYS A 478
 None
 1.45A 4duzL-4woeA:
undetectable		 4duzL-4woeA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9f DOWN SYNDROME CELL
ADHESION MOLECULE
ISOFORM 6.9

(Drosophila
melanogaster) 		PF07679
(I-set) 		3 LYS A 219
PRO A 216
LYS A 213
 None
 1.31A 4duzL-4x9fA:
undetectable		 4duzL-4x9fA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd2 ENDO-1,4-D-GLUCANASE

(Aliivibrio
fischeri) 		PF01270
(Glyco_hydro_8) 		3 LYS A 238
PRO A 292
LYS A 313
 None
 1.48A 4duzL-5cd2A:
undetectable		 4duzL-5cd2A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum) 		no annotation 3 LYS B 398
PRO B 399
LYS B 421
 None
 1.47A 4duzL-5cwwB:
undetectable		 4duzL-5cwwB:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		3 LYS A  14
PRO A  16
LYS A   9
 None
 1.28A 4duzL-5d6nA:
undetectable		 4duzL-5d6nA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msn DCC1 PROTEIN

(Saccharomyces
cerevisiae) 		PF09724
(Dcc1) 		3 LYS A 326
PRO A 325
LYS A 364
 None
 1.34A 4duzL-5msnA:
undetectable		 4duzL-5msnA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyx HEAVY CHAIN

(Homo sapiens) 		no annotation 3 LYS H  66
PRO H  63
LYS H  60
 None
 1.08A 4duzL-5nyxH:
undetectable		 4duzL-5nyxH:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oes GLUTATHIONE
SYNTHETASE

(Solanum
tuberosum) 		no annotation 3 LYS A 372
PRO A 373
LYS A 318
 ADP  A 501 (-2.9A)
None
ADP  A 501 (-3.9A)
 1.46A 4duzL-5oesA:
undetectable		 4duzL-5oesA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 3 LYS A  66
PRO A  69
LYS A 167
 None
 1.36A 4duzL-5opqA:
undetectable		 4duzL-5opqA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfr 26S PROTEASOME
REGULATORY SUBUNIT
6B
PROTEASOME SUBUNIT
ALPHA TYPE-2

(Homo sapiens) 		no annotation 3 LYS H 165
PRO H  34
LYS D 418
 None
 1.49A 4duzL-5vfrH:
undetectable		 4duzL-5vfrH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1

(Caenorhabditis
elegans) 		no annotation 3 LYS A 227
PRO A 225
LYS A 332
 None
 1.29A 4duzL-6b5dA:
undetectable		 4duzL-6b5dA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT C'
V-TYPE PROTON ATPASE
SUBUNIT D

(Saccharomyces
cerevisiae) 		no annotation 3 LYS B   2
PRO B 203
LYS D  40
 None
 1.15A 4duzL-6c6lB:
undetectable		 4duzL-6c6lB:
19.71