SIMILAR PATTERNS OF AMINO ACIDS FOR 4DU2_A_LDPA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2z PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermococcus
litoralis) 		PF01470
(Peptidase_C15) 		4 ALA A 201
ALA A 120
LEU A 125
THR A 124
 None
 0.84A 4du2A-1a2zA:
0.0		 4du2A-1a2zA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		4 ALA A 246
ALA A 174
ALA A  80
LEU A  82
 None
 0.94A 4du2A-1csjA:
0.0		 4du2A-1csjA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dub 2-ENOYL-COA
HYDRATASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 ALA A 154
PHE A 160
ALA A 138
ALA A 132
 None
 0.82A 4du2A-1dubA:
0.0		 4du2A-1dubA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzf COMPLEMENT FACTOR
C4A

(Homo sapiens) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 ALA A1249
ALA A1202
ALA A1171
LEU A1198
 None
 0.95A 4du2A-1hzfA:
0.0		 4du2A-1hzfA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I

(Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ALA A 280
PHE A 304
ALA A 471
PRO A 275
 None
 0.94A 4du2A-1i1qA:
0.0		 4du2A-1i1qA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 ALA A 757
PHE A 763
ALA A 815
PRO A 824
 None
 0.91A 4du2A-1kblA:
undetectable		 4du2A-1kblA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n11 ANKYRIN

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 ALA A 610
ALA A 628
LEU A 606
THR A 604
 None
 0.85A 4du2A-1n11A:
0.0		 4du2A-1n11A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE

(Oryctolagus
cuniculus) 		PF00248
(Aldo_ket_red) 		4 ALA A 218
ALA A 253
PRO A 252
LEU A 235
 None
NDP  A1003 (-3.3A)
None
None
 0.83A 4du2A-1q5mA:
0.0		 4du2A-1q5mA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		4 ALA A 506
ALA A 276
ALA A 417
THR A 421
 None
 0.82A 4du2A-1t6pA:
0.0		 4du2A-1t6pA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toa PROTEIN (PERIPLASMIC
BINDING PROTEIN
TROA)

(Treponema
pallidum) 		PF01297
(ZnuA) 		4 PHE A 246
ALA A 244
ALA A 304
LEU A 306
 None
 0.96A 4du2A-1toaA:
undetectable		 4du2A-1toaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		4 ALA A 371
PHE A 366
ALA A 107
ALA A 122
 None
None
None
MHO  A 105 ( 3.6A)
 0.94A 4du2A-1up2A:
undetectable		 4du2A-1up2A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		4 ALA A 141
ALA A 247
ALA A 427
THR A 430
 None
None
NAD  A1002 ( 4.0A)
None
 0.88A 4du2A-1vrqA:
undetectable		 4du2A-1vrqA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfc ALANINE RACEMASE

(Mycobacterium
tuberculosis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ALA A 120
ALA A 128
ALA A  99
PRO A  98
 None
 0.92A 4du2A-1xfcA:
undetectable		 4du2A-1xfcA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfc ALANINE RACEMASE

(Mycobacterium
tuberculosis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ALA A 128
ALA A  99
ALA A 120
THR A 124
 None
 0.79A 4du2A-1xfcA:
undetectable		 4du2A-1xfcA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkd ISOCITRATE
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00180
(Iso_dh) 		4 ALA A 305
ALA A 248
LEU A 212
THR A 209
 None
 0.89A 4du2A-1xkdA:
undetectable		 4du2A-1xkdA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bc0 NADH OXIDASE

(Streptococcus
pyogenes) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A  15
ALA A 110
ALA A 313
THR A 316
 None
None
FAD  A 601 ( 3.7A)
None
 0.94A 4du2A-2bc0A:
undetectable		 4du2A-2bc0A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cc1 BETA-LACTAMASE

(Mycolicibacterium
fortuitum) 		PF13354
(Beta-lactamase2) 		4 ALA A  78
PHE A 151
ALA A 192
LEU A 199
 None
 0.91A 4du2A-2cc1A:
undetectable		 4du2A-2cc1A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cre HEF-LIKE PROTEIN

(Homo sapiens) 		PF14604
(SH3_9) 		4 ALA A  57
PHE A  26
ALA A  12
LEU A  62
 None
 0.90A 4du2A-2creA:
undetectable		 4du2A-2creA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 ALA A 206
PHE A  76
ALA A 196
LEU A 193
 None
 0.82A 4du2A-2dc0A:
undetectable		 4du2A-2dc0A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		4 ALA A 168
PHE A 431
ALA A 448
ALA A 440
 None
 0.95A 4du2A-2dpyA:
undetectable		 4du2A-2dpyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4i HYPOTHETICAL PROTEIN
TM0957

(Thermotoga
maritima) 		PF10054
(DUF2291) 		4 ALA A 141
PHE A 146
ALA A 156
LEU A  48
 MLY  A 142 ( 3.1A)
MLY  A 142 ( 4.3A)
None
None
 0.85A 4du2A-2f4iA:
undetectable		 4du2A-2f4iA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		4 ALA A 142
ALA A 248
ALA A 428
THR A 431
 None
NAD  A 999 (-4.8A)
NAD  A 999 ( 4.1A)
None
 0.89A 4du2A-2gahA:
undetectable		 4du2A-2gahA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 ALA A 238
PHE A 224
ALA A 253
LEU A 271
 None
 0.86A 4du2A-2h21A:
undetectable		 4du2A-2h21A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iex DIHYDROXYNAPTHOIC
ACID SYNTHETASE

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		4 ALA A 133
PHE A 139
ALA A 117
ALA A 111
 None
 0.83A 4du2A-2iexA:
undetectable		 4du2A-2iexA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 ALA A 218
ALA A 253
PRO A 252
LEU A 235
 None
NAP  A   1 (-3.5A)
BME  A 327 (-4.5A)
None
 0.90A 4du2A-2ipjA:
undetectable		 4du2A-2ipjA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)

(Homo sapiens) 		no annotation 4 PHE A 115
ALA A  86
PRO A  90
LEU A 163
 None
 0.90A 4du2A-2jdxA:
undetectable		 4du2A-2jdxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozg GCN5-RELATED
N-ACETYLTRANSFERASE

(Trichormus
variabilis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 ALA A 120
PRO A 119
LEU A 124
THR A 121
 COA  A 500 (-3.1A)
None
COA  A 500 (-3.5A)
COA  A 500 (-3.1A)
 0.88A 4du2A-2ozgA:
undetectable		 4du2A-2ozgA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbp ENOYL-COA HYDRATASE
SUBUNIT I

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		4 ALA A 122
PHE A 128
ALA A 106
ALA A 100
 None
 0.84A 4du2A-2pbpA:
undetectable		 4du2A-2pbpA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvu ARTJ

(Geobacillus
stearothermophilus) 		PF00497
(SBP_bac_3) 		4 ALA A 121
PHE A 200
ALA A 140
LEU A 144
 None
 0.94A 4du2A-2pvuA:
undetectable		 4du2A-2pvuA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		4 PHE A 176
ALA A 235
ALA A 218
PRO A 219
 None
 0.71A 4du2A-2qa2A:
undetectable		 4du2A-2qa2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r14 MORPHINONE REDUCTASE

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		4 ALA A 313
PHE A 327
ALA A 324
LEU A  11
 None
 0.83A 4du2A-2r14A:
undetectable		 4du2A-2r14A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzf NAPHTHOATE SYNTHASE

(Staphylococcus
aureus) 		PF00378
(ECH_1) 		4 ALA A 134
PHE A 140
ALA A 118
ALA A 112
 None
 0.92A 4du2A-2uzfA:
undetectable		 4du2A-2uzfA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvt GLUTAMATE RACEMASE

(Enterococcus
faecalis) 		PF01177
(Asp_Glu_race) 		4 ALA A 251
PHE A 247
ALA A 262
LEU A 260
 None
 0.95A 4du2A-2vvtA:
undetectable		 4du2A-2vvtA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625

(Thermus
thermophilus) 		PF13277
(YmdB) 		4 ALA A 231
PHE A 229
ALA A  34
LEU A   4
 None
 0.94A 4du2A-2z06A:
undetectable		 4du2A-2z06A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 ALA A 212
PHE A 174
ALA A 170
THR A 249
 None
 0.93A 4du2A-2zzgA:
undetectable		 4du2A-2zzgA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Escherichia
coli) 		PF01380
(SIS) 		4 ALA A 346
PHE A 281
ALA A 238
ALA A 243
 None
 0.74A 4du2A-3c3jA:
undetectable		 4du2A-3c3jA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjt RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF06325
(PrmA) 		4 ALA A 137
ALA A 110
PRO A  74
LEU A 114
 None
 0.88A 4du2A-3cjtA:
undetectable		 4du2A-3cjtA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		4 ALA A 206
ALA A 169
ALA A 412
PRO A 413
 None
 0.70A 4du2A-3eafA:
undetectable		 4du2A-3eafA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Mus musculus) 		PF00288
(GHMP_kinases_N) 		4 ALA A 135
ALA A  14
PRO A  15
LEU A 163
 None
 0.87A 4du2A-3f0nA:
undetectable		 4du2A-3f0nA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmf DETHIOBIOTIN
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF13500
(AAA_26) 		4 ALA A  21
PHE A 216
ALA A 194
LEU A 196
 None
 0.91A 4du2A-3fmfA:
undetectable		 4du2A-3fmfA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		4 ALA A 380
PHE A 332
LEU A 369
THR A 370
 None
 0.64A 4du2A-3fqdA:
undetectable		 4du2A-3fqdA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gha DISULFIDE BOND
FORMATION PROTEIN D

(Bacillus
subtilis) 		PF13462
(Thioredoxin_4) 		4 ALA A 113
PHE A 128
PRO A 146
LEU A 164
 None
 0.79A 4du2A-3ghaA:
undetectable		 4du2A-3ghaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ALA A 785
PHE A 770
ALA A 605
LEU A 607
 None
 0.92A 4du2A-3iayA:
undetectable		 4du2A-3iayA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvd LIPOPROTEIN

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		4 ALA D  84
PHE D 141
ALA D  79
LEU D 133
 None
 0.88A 4du2A-3kvdD:
undetectable		 4du2A-3kvdD:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 ALA A 218
ALA A 253
PRO A 252
LEU A 235
 NAD  A 327 (-4.9A)
NAD  A 327 (-3.4A)
None
None
 0.93A 4du2A-3ln3A:
undetectable		 4du2A-3ln3A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkh NITROALKANE OXIDASE

(Podospora
anserina) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A 354
ALA A 274
ALA A 334
THR A 331
 None
 0.93A 4du2A-3mkhA:
undetectable		 4du2A-3mkhA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moy PROBABLE ENOYL-COA
HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 ALA A 123
PHE A 129
ALA A 107
ALA A 101
 None
 0.85A 4du2A-3moyA:
undetectable		 4du2A-3moyA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pao ADENOSINE DEAMINASE

(Pseudomonas
aeruginosa) 		PF00962
(A_deaminase) 		4 ALA A 155
PHE A 111
ALA A 161
LEU A 137
 None
 0.91A 4du2A-3paoA:
undetectable		 4du2A-3paoA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plw RECOMBINATION
ENHANCEMENT FUNCTION
PROTEIN

(Escherichia
virus P1) 		PF16786
(RecA_dep_nuc) 		4 ALA A  98
PHE A 164
PRO A 128
LEU A 174
 ZN  A 188 ( 4.6A)
None
None
None
 0.73A 4du2A-3plwA:
undetectable		 4du2A-3plwA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pve AGRIN, AGRIN PROTEIN

(Mus musculus) 		PF00054
(Laminin_G_1) 		4 ALA A1531
PHE A1511
ALA A1596
ALA A1600
 None
 0.92A 4du2A-3pveA:
undetectable		 4du2A-3pveA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0g ENOYL-COA HYDRATASE
ECHA8

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		4 ALA A 121
PHE A 127
ALA A 105
ALA A  99
 None
 0.86A 4du2A-3q0gA:
undetectable		 4du2A-3q0gA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua) 		PF00294
(PfkB) 		4 PHE A  50
ALA A 259
ALA A 274
THR A 270
 None
 0.88A 4du2A-3q1yA:
undetectable		 4du2A-3q1yA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qka ENOYL-COA HYDRATASE,
ECHA5

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 ALA A 120
PHE A 126
ALA A 104
ALA A  98
 None
 0.84A 4du2A-3qkaA:
undetectable		 4du2A-3qkaA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmn HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Vibrio cholerae) 		PF01648
(ACPS) 		4 ALA A  94
PHE A  76
ALA A  59
LEU A  63
 None
 0.91A 4du2A-3qmnA:
undetectable		 4du2A-3qmnA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxi ENOYL-COA HYDRATASE
ECHA1

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 ALA A 124
PHE A 130
ALA A 108
ALA A 102
 None
 0.80A 4du2A-3qxiA:
undetectable		 4du2A-3qxiA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0o CARNITINYL-COA
DEHYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 ALA A 130
PHE A 136
ALA A 114
ALA A 108
 None
 0.77A 4du2A-3r0oA:
undetectable		 4du2A-3r0oA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9s CARNITINYL-COA
DEHYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 ALA A 124
PHE A 130
ALA A 108
ALA A 102
 None
 0.75A 4du2A-3r9sA:
undetectable		 4du2A-3r9sA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sll PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		4 ALA A 129
PHE A 135
ALA A 113
ALA A 107
 None
 0.95A 4du2A-3sllA:
undetectable		 4du2A-3sllA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PHE A 701
ALA A 709
LEU A 730
THR A 732
 None
 0.88A 4du2A-3sunA:
undetectable		 4du2A-3sunA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upn PENICILLIN-BINDING
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		4 ALA A 230
PHE A 305
ALA A 390
ALA A 396
 None
 0.77A 4du2A-3upnA:
undetectable		 4du2A-3upnA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium) 		no annotation 4 ALA B 215
PHE B 223
ALA B 222
ALA B 571
 None
 0.87A 4du2A-3x17B:
undetectable		 4du2A-3x17B:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		4 ALA A 370
ALA A 352
LEU A 356
THR A 357
 None
 0.83A 4du2A-4djiA:
undetectable		 4du2A-4djiA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emy AMINOTRANSFERASE
CLASS I AND II

(Anaerococcus
prevotii) 		PF00155
(Aminotran_1_2) 		4 ALA A 103
ALA A 302
ALA A  73
PRO A  74
 None
 0.76A 4du2A-4emyA:
undetectable		 4du2A-4emyA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fso PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 ALA A 115
ALA A  98
LEU A 134
THR A 159
 None
C8E  A 507 ( 3.7A)
None
None
 0.95A 4du2A-4fsoA:
undetectable		 4du2A-4fsoA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE

(Escherichia
coli) 		PF00378
(ECH_1) 		4 ALA A 119
PHE A 125
ALA A 103
ALA A  97
 None
 0.81A 4du2A-4fzwA:
undetectable		 4du2A-4fzwA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 PHE A 272
ALA A 305
ALA A 245
THR A 249
 None
 0.67A 4du2A-4htgA:
undetectable		 4du2A-4htgA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4z NAPHTHOATE SYNTHASE

(Synechocystis
sp. PCC 6803) 		PF00378
(ECH_1) 		4 ALA A 136
PHE A 142
ALA A 120
ALA A 114
 None
 0.89A 4du2A-4i4zA:
undetectable		 4du2A-4i4zA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io6 AVGLUR1 LIGAND
BINDING DOMAIN

(Adineta vaga) 		PF00497
(SBP_bac_3) 		4 ALA A  73
ALA A  82
ALA A  61
PRO A  62
 None
 0.78A 4du2A-4io6A:
undetectable		 4du2A-4io6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixw HALOHYDRIN
DEHALOGENASE

(Agrobacterium
tumefaciens) 		PF13561
(adh_short_C2) 		5 ALA A 134
ALA A 150
ALA A 174
PRO A 175
THR A 131
 IXW  A 302 (-3.5A)
None
None
IXW  A 302 (-4.6A)
None
 1.04A 4du2A-4ixwA:
undetectable		 4du2A-4ixwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jfc ENOYL-COA HYDRATASE

(Polaromonas sp.
JS666) 		PF00378
(ECH_1) 		4 ALA A 125
PHE A 131
ALA A 109
ALA A 103
 None
 0.77A 4du2A-4jfcA:
undetectable		 4du2A-4jfcA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng4 PHOSPHOGLYCERATE
KINASE

(Coxiella
burnetii) 		PF00162
(PGK) 		4 ALA A 166
ALA A 385
LEU A 389
THR A 390
 None
 0.85A 4du2A-4ng4A:
undetectable		 4du2A-4ng4A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ALA A 257
PHE A  54
ALA A 117
THR A  13
 None
 0.83A 4du2A-4nzsA:
undetectable		 4du2A-4nzsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		4 ALA A 503
ALA A 404
ALA A 387
THR A 407
 None
 0.75A 4du2A-4ojzA:
undetectable		 4du2A-4ojzA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE

(Escherichia
coli) 		PF06315
(AceK) 		4 ALA A 266
ALA A 261
PRO A 262
LEU A 139
 None
 0.92A 4du2A-4p69A:
undetectable		 4du2A-4p69A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7y METHIONINE
GAMMA-LYASE

(Citrobacter
freundii) 		PF01053
(Cys_Met_Meta_PP) 		4 ALA A 109
ALA A 137
ALA A 159
THR A 157
 None
 0.89A 4du2A-4p7yA:
undetectable		 4du2A-4p7yA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		4 PHE A 103
ALA A 128
ALA A 158
LEU A 132
 None
 0.82A 4du2A-4v2dA:
undetectable		 4du2A-4v2dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		4 ALA A 293
ALA A 325
LEU A 285
THR A 286
 None
 0.95A 4du2A-4w1wA:
undetectable		 4du2A-4w1wA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD

(Mycobacterium
tuberculosis) 		PF13500
(AAA_26) 		4 ALA A  21
PHE A 216
ALA A 194
LEU A 196
 None
None
None
CTP  A 301 ( 4.4A)
 0.85A 4du2A-4wopA:
undetectable		 4du2A-4wopA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0m ENOYL-COA HYDRATASE

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		4 ALA A 120
PHE A 126
ALA A 104
ALA A  98
 None
 0.79A 4du2A-4z0mA:
undetectable		 4du2A-4z0mA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c17 MERB2

(Bacillus
megaterium) 		PF03243
(MerB) 		4 ALA A 197
ALA A 103
LEU A 107
THR A 106
 None
 0.85A 4du2A-5c17A:
undetectable		 4du2A-5c17A:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		4 ALA A 264
ALA A 328
PRO A 329
THR A 438
 HEM  A 501 (-3.6A)
HEM  A 501 ( 3.8A)
None
None
 0.51A 4du2A-5e78A:
63.3		 4du2A-5e78A:
97.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed7 TEGUMENT PROTEIN
UL21

(Human
alphaherpesvirus
1) 		PF03252
(Herpes_UL21) 		4 ALA A 461
PRO A 418
LEU A 482
THR A 483
 None
 0.92A 4du2A-5ed7A:
undetectable		 4du2A-5ed7A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH) 		4 ALA A1581
PHE A1561
ALA A1556
THR A1528
 SAH  A1701 (-3.5A)
None
None
None
 0.93A 4du2A-5gutA:
undetectable		 4du2A-5gutA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h36 UNCHARACTERIZED
PROTEIN TRIC

(Rhodobacter
sphaeroides) 		no annotation 4 ALA E 156
ALA E 108
ALA E 127
THR E 128
 None
None
PX4  E 301 ( 4.8A)
None
 0.85A 4du2A-5h36E:
undetectable		 4du2A-5h36E:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs5 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SARX

(Staphylococcus
aureus) 		no annotation 4 ALA A  58
ALA A  35
LEU A  39
THR A  40
 None
 0.87A 4du2A-5hs5A:
undetectable		 4du2A-5hs5A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxz BARBITURASE

(Rhodococcus
erythropolis) 		PF09663
(Amido_AtzD_TrzD) 		4 ALA A  94
ALA A  56
ALA A  18
LEU A  12
 None
 0.88A 4du2A-5hxzA:
undetectable		 4du2A-5hxzA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		4 ALA A 419
PHE A 382
ALA A 339
LEU A 335
 None
 0.93A 4du2A-5i92A:
undetectable		 4du2A-5i92A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic1 TALIN-1

(Mus musculus) 		no annotation 4 ALA A1610
ALA A1429
ALA A1366
LEU A1433
 None
 0.91A 4du2A-5ic1A:
undetectable		 4du2A-5ic1A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im5 DESIGNED
KETO-HYDROXYGLUTARAT
E-ALDOLASE/KETO-DEOX
Y-PHOSPHOGLUCONATE
ALDOLASE

(Vibrionales
bacterium
SWAT-3) 		no annotation 4 ALA P  67
PHE P  44
ALA P  49
ALA P  82
 None
 0.91A 4du2A-5im5P:
undetectable		 4du2A-5im5P:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 ALA B1268
ALA B1221
ALA B1190
LEU B1217
 None
A2G  B1508 (-4.5A)
None
None
 0.90A 4du2A-5jpnB:
undetectable		 4du2A-5jpnB:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC

(Streptomyces
sp. BC16019) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 ALA A 294
ALA A 485
ALA A 180
THR A 177
 None
 0.86A 4du2A-5lhkA:
undetectable		 4du2A-5lhkA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m23 WD REPEAT-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40) 		4 ALA A 317
PHE A  53
ALA A  74
LEU A 329
 None
 0.94A 4du2A-5m23A:
undetectable		 4du2A-5m23A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		4 ALA A1415
ALA A1432
ALA A1402
THR A1231
 None
 0.95A 4du2A-5n8oA:
undetectable		 4du2A-5n8oA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2o J30 CCH

(Thermobacillus
composti) 		no annotation 4 ALA A  90
ALA A 530
PRO A 531
THR A 529
 None
 0.93A 4du2A-5u2oA:
undetectable		 4du2A-5u2oA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2o J30 CCH

(Thermobacillus
composti) 		no annotation 4 ALA A 418
ALA A 441
ALA A 532
PRO A 531
 None
 0.95A 4du2A-5u2oA:
undetectable		 4du2A-5u2oA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uai METHIONYL-TRNA
FORMYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 PHE A 306
ALA A 244
PRO A 245
LEU A 287
 None
 0.90A 4du2A-5uaiA:
undetectable		 4du2A-5uaiA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH

(Brachybacterium
faecium) 		PF01636
(APH) 		4 PHE A 239
ALA A 258
ALA A 224
PRO A 223
 None
 0.91A 4du2A-5uxbA:
undetectable		 4du2A-5uxbA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		no annotation 4 ALA A 214
ALA A 230
LEU A 176
THR A 181
 None
 0.90A 4du2A-6cc0A:
undetectable		 4du2A-6cc0A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus) 		no annotation 4 ALA A 155
ALA A  28
ALA A 188
THR A 191
 None
 0.82A 4du2A-6d0nA:
undetectable		 4du2A-6d0nA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3

(Homo sapiens) 		no annotation 4 ALA A 218
ALA A 253
PRO A 252
LEU A 235
 None
NAP  A 401 (-3.4A)
None
None
 0.89A 4du2A-6f2uA:
undetectable		 4du2A-6f2uA:
9.87