SIMILAR PATTERNS OF AMINO ACIDS FOR 4DTZ_B_LDPB501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byr PROTEIN
(ENDONUCLEASE)

(Salmonella
enterica) 		PF13091
(PLDc_2) 		4 PHE A 110
ALA A 116
ALA A  39
PRO A  40
 None
 1.13A 4dtzB-1byrA:
0.0		 4dtzB-1byrA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4b HUMAN CELL
DEATH-INDUCING
EFFECTOR B

(Homo sapiens) 		PF02017
(CIDE-N) 		4 ALA A  54
PRO A  33
LEU A  59
THR A  55
 None
 1.06A 4dtzB-1d4bA:
undetectable		 4dtzB-1d4bA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 PHE A 236
ALA A 436
ALA A 226
LEU A 427
 None
 1.00A 4dtzB-1d6mA:
0.0		 4dtzB-1d6mA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ

(Escherichia
virus G4) 		PF02305
(Phage_F) 		4 ALA 1 163
ALA 1 171
PRO 1 172
THR 1 170
 None
 1.13A 4dtzB-1gff1:
undetectable		 4dtzB-1gff1:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia) 		PF00390
(malic)
PF03949
(Malic_M) 		4 PHE A 309
ALA A 316
ALA A 284
THR A 283
 None
None
None
NAP  A1581 (-3.9A)
 1.04A 4dtzB-1gq2A:
0.0		 4dtzB-1gq2A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwc GLUTATHIONE
S-TRANSFERASE TSI-1

(Aegilops
tauschii) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 PHE A 199
ALA A 205
LEU A  23
THR A  19
 None
 1.12A 4dtzB-1gwcA:
0.0		 4dtzB-1gwcA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfr LIPASE

(Streptomyces
exfoliatus) 		PF03403
(PAF-AH_p_II) 		4 ALA A 140
ALA A 150
LEU A 147
THR A 167
 None
 1.04A 4dtzB-1jfrA:
0.0		 4dtzB-1jfrA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ALA A 320
PRO A 360
LEU A  55
THR A  56
 None
 0.90A 4dtzB-1jr1A:
undetectable		 4dtzB-1jr1A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0w ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 PHE A 511
ALA A 514
ALA A 519
PRO A 520
 None
 1.02A 4dtzB-1l0wA:
0.0		 4dtzB-1l0wA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 PHE A 433
ALA A 519
LEU A 425
THR A 421
 None
 0.96A 4dtzB-1l5jA:
undetectable		 4dtzB-1l5jA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		4 PHE A 262
ALA A 258
PRO A 230
LEU A 342
 None
 1.01A 4dtzB-1q15A:
undetectable		 4dtzB-1q15A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE

(Rattus
norvegicus) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 ALA A 184
ALA A 188
PRO A 189
THR A 187
 None
None
BME  A 312 (-4.8A)
None
 1.04A 4dtzB-1s3iA:
undetectable		 4dtzB-1s3iA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thm THERMITASE

(Thermoactinomyces
vulgaris) 		PF00082
(Peptidase_S8) 		4 ALA A 235
ALA A  93
PRO A  94
THR A  92
 None
 1.07A 4dtzB-1thmA:
undetectable		 4dtzB-1thmA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vft ALANINE RACEMASE

(Streptomyces
lavendulae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 PHE A 169
ALA A 172
PRO A 216
THR A 214
 None
 1.06A 4dtzB-1vftA:
undetectable		 4dtzB-1vftA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyh PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
BETA SUBUNIT

(Homo sapiens) 		PF13472
(Lipase_GDSL_2) 		4 ALA A 120
ALA A   9
LEU A  82
THR A  78
 None
 1.07A 4dtzB-1vyhA:
undetectable		 4dtzB-1vyhA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 PHE A 299
ALA A 306
ALA A 274
THR A 273
 None
 1.08A 4dtzB-2aw5A:
undetectable		 4dtzB-2aw5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9j GREEN FLUORESCENT
PROTEIN FP512

(Cerianthus
membranaceus) 		PF01353
(GFP) 		4 PHE A  87
ALA A  86
PRO A  33
LEU A 114
 None
 1.12A 4dtzB-2c9jA:
undetectable		 4dtzB-2c9jA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF00496
(SBP_bac_5) 		4 ALA A 357
ALA A 352
PRO A 546
THR A 354
 None
 1.09A 4dtzB-2d5wA:
undetectable		 4dtzB-2d5wA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id0 EXORIBONUCLEASE 2

(Escherichia
coli) 		PF00575
(S1)
PF00773
(RNB)
PF08206
(OB_RNB) 		4 PHE A 301
ALA A 303
ALA A 227
LEU A 192
 None
 1.08A 4dtzB-2id0A:
undetectable		 4dtzB-2id0A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 ALA A 218
ALA A 253
PRO A 252
LEU A 235
 None
NAP  A   1 (-3.5A)
BME  A 327 (-4.5A)
None
 0.93A 4dtzB-2ipjA:
undetectable		 4dtzB-2ipjA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)

(Homo sapiens) 		no annotation 4 PHE A 115
ALA A  86
PRO A  90
LEU A 163
 None
 0.98A 4dtzB-2jdxA:
undetectable		 4dtzB-2jdxA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n9u RESPONSE REGULATOR

(Erythrobacter
litoralis) 		PF00072
(Response_reg) 		4 ALA A 206
ALA A 173
LEU A 197
THR A 175
 None
 1.05A 4dtzB-2n9uA:
undetectable		 4dtzB-2n9uA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozg GCN5-RELATED
N-ACETYLTRANSFERASE

(Trichormus
variabilis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 ALA A 120
PRO A 119
LEU A 124
THR A 121
 COA  A 500 (-3.1A)
None
COA  A 500 (-3.5A)
COA  A 500 (-3.1A)
 0.90A 4dtzB-2ozgA:
undetectable		 4dtzB-2ozgA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2s PUTATIVE
OXIDOREDUCTASE

(Pectobacterium
atrosepticum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 PHE A 119
ALA A  82
PRO A  97
LEU A  99
 None
 1.07A 4dtzB-2p2sA:
undetectable		 4dtzB-2p2sA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		4 PHE A 176
ALA A 235
ALA A 218
PRO A 219
 None
 0.66A 4dtzB-2qa2A:
undetectable		 4dtzB-2qa2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcz OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR YAET

(Escherichia
coli) 		PF07244
(POTRA) 		4 PHE A  31
ALA A  42
PRO A  47
LEU A  66
 None
 1.11A 4dtzB-2qczA:
undetectable		 4dtzB-2qczA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		4 ALA A  82
ALA A  67
LEU A  78
THR A  71
 None
 1.11A 4dtzB-2r9hA:
undetectable		 4dtzB-2r9hA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		4 PHE C  98
ALA C 148
PRO C 195
LEU C 152
 None
 1.08A 4dtzB-2ynmC:
undetectable		 4dtzB-2ynmC:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ALA A 410
ALA A  34
PRO A  35
LEU A 414
 None
 1.12A 4dtzB-3aoeA:
undetectable		 4dtzB-3aoeA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh9 THIOREDOXIN
REDUCTASE 1

(Drosophila
melanogaster) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PHE A 244
ALA A 234
LEU A 200
THR A 368
 None
 1.05A 4dtzB-3dh9A:
undetectable		 4dtzB-3dh9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxq CHOLINE/ETHANOLAMINE
KINASE FAMILY
PROTEIN

(Mesorhizobium
loti) 		PF01633
(Choline_kinase) 		4 PHE A 123
ALA A 174
ALA A  67
LEU A 116
 None
 1.00A 4dtzB-3dxqA:
undetectable		 4dtzB-3dxqA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 PHE A 825
ALA A 665
ALA A 696
PRO A 697
 None
 1.06A 4dtzB-3dy5A:
undetectable		 4dtzB-3dy5A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eup TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Cytophaga
hutchinsonii) 		PF00440
(TetR_N) 		4 ALA A  57
ALA A  19
PRO A  20
THR A  18
 None
 1.04A 4dtzB-3eupA:
undetectable		 4dtzB-3eupA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exs RMPD
(HEXULOSE-6-PHOSPHAT
E SYNTHASE)

(Streptococcus
mutans) 		PF00215
(OMPdecase) 		4 PHE A 212
ALA A 195
PRO A 205
THR A 200
 None
 1.11A 4dtzB-3exsA:
undetectable		 4dtzB-3exsA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Mus musculus) 		PF00288
(GHMP_kinases_N) 		4 ALA A 135
ALA A  14
PRO A  15
LEU A 163
 None
 0.89A 4dtzB-3f0nA:
undetectable		 4dtzB-3f0nA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 PHE A 665
ALA A 664
ALA A 733
LEU A 661
 None
 1.07A 4dtzB-3fedA:
undetectable		 4dtzB-3fedA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 PHE A  55
ALA A  64
ALA A  23
THR A  24
 None
 1.09A 4dtzB-3g7rA:
undetectable		 4dtzB-3g7rA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 ALA A 218
ALA A 253
PRO A 252
LEU A 235
 NAD  A 327 (-4.9A)
NAD  A 327 (-3.4A)
None
None
 0.95A 4dtzB-3ln3A:
undetectable		 4dtzB-3ln3A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Yersinia pestis) 		PF04166
(PdxA) 		4 ALA A 180
ALA A 230
PRO A 229
THR A 226
 None
 1.06A 4dtzB-3lxyA:
undetectable		 4dtzB-3lxyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6a ATP-DEPENDENT
PROTEASE LA 1

(Bacillus
subtilis) 		PF00004
(AAA)
PF05362
(Lon_C) 		4 ALA A 721
ALA A 734
PRO A 735
THR A 702
 None
 1.03A 4dtzB-3m6aA:
undetectable		 4dtzB-3m6aA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oo3 OXY PROTEIN

(Actinoplanes
teichomyceticus) 		PF00067
(p450) 		4 PHE A 130
ALA A 134
ALA A 345
LEU A 118
 None
 0.93A 4dtzB-3oo3A:
32.0		 4dtzB-3oo3A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5m ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 ALA A 136
ALA A 153
LEU A 140
THR A 149
 None
 1.00A 4dtzB-3p5mA:
undetectable		 4dtzB-3p5mA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		4 PHE A 117
ALA A 115
PRO A   5
LEU A 112
 None
 1.03A 4dtzB-3psgA:
undetectable		 4dtzB-3psgA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua) 		PF00294
(PfkB) 		4 PHE A  50
ALA A 259
ALA A 274
THR A 270
 None
 0.87A 4dtzB-3q1yA:
undetectable		 4dtzB-3q1yA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 377
ALA A 381
ALA A 367
PRO A 368
 None
 1.01A 4dtzB-3q4tA:
undetectable		 4dtzB-3q4tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2

(Rattus
norvegicus) 		PF01070
(FMN_dh) 		4 ALA A 325
ALA A  70
PRO A  71
THR A  59
 None
 0.86A 4dtzB-3sgzA:
undetectable		 4dtzB-3sgzA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PHE A 701
ALA A 709
LEU A 730
THR A 732
 None
 0.88A 4dtzB-3sunA:
undetectable		 4dtzB-3sunA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttk POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		4 ALA A 148
ALA A 153
PRO A 154
LEU A 170
 None
 1.12A 4dtzB-3ttkA:
undetectable		 4dtzB-3ttkA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5r PROTEIN GAL3

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 PHE A 237
ALA A 221
ALA A 399
LEU A  50
 None
 1.12A 4dtzB-3v5rA:
undetectable		 4dtzB-3v5rA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw5 CELLOBIOSE
2-EPIMERASE

(Ruminococcus
albus) 		PF07221
(GlcNAc_2-epim) 		4 PHE A  56
ALA A  60
LEU A  10
THR A  11
 None
 1.00A 4dtzB-3vw5A:
undetectable		 4dtzB-3vw5A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxs CRYPTOCHROME B

(Rhodobacter
sphaeroides) 		PF04244
(DPRP) 		4 PHE A 372
ALA A 376
PRO A 335
LEU A 502
 None
 0.88A 4dtzB-3zxsA:
undetectable		 4dtzB-3zxsA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7l MYOSIN IE HEAVY
CHAIN

(Dictyostelium
discoideum) 		PF00063
(Myosin_head) 		4 PHE C 146
ALA C 252
LEU C 256
THR C 255
 None
 0.94A 4dtzB-4a7lC:
undetectable		 4dtzB-4a7lC:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7p UDP-GLUCOSE
DEHYDROGENASE

(Sphingomonas
elodea) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ALA A 361
ALA A 334
PRO A 335
LEU A 322
 None
 1.12A 4dtzB-4a7pA:
undetectable		 4dtzB-4a7pA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 PHE A 105
ALA A  95
ALA A  72
LEU A  69
 None
 1.00A 4dtzB-4azvA:
undetectable		 4dtzB-4azvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpl IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 ALA A 246
ALA A 262
LEU A 225
THR A 222
 None
 1.08A 4dtzB-4bplA:
undetectable		 4dtzB-4bplA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		4 ALA A 260
ALA A 231
LEU A 256
THR A 227
 None
 1.06A 4dtzB-4hjwA:
undetectable		 4dtzB-4hjwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 PHE A 272
ALA A 305
ALA A 245
THR A 249
 None
 0.73A 4dtzB-4htgA:
undetectable		 4dtzB-4htgA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixw HALOHYDRIN
DEHALOGENASE

(Agrobacterium
tumefaciens) 		PF13561
(adh_short_C2) 		4 ALA A 150
ALA A 174
PRO A 175
THR A 131
 None
None
IXW  A 302 (-4.6A)
None
 0.71A 4dtzB-4ixwA:
undetectable		 4dtzB-4ixwA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		4 PHE A  86
ALA A 210
LEU A 232
THR A 231
 None
None
None
LLP  A 230 ( 4.0A)
 1.13A 4dtzB-4j5uA:
undetectable		 4dtzB-4j5uA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Cordyceps
militaris) 		PF04909
(Amidohydro_2) 		4 ALA A 260
ALA A 231
LEU A 256
THR A 227
 None
 1.10A 4dtzB-4lanA:
undetectable		 4dtzB-4lanA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nur PSDSA

(Pseudomonas sp.
S9) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 PHE A 223
ALA A 227
ALA A 559
THR A 556
 None
 1.03A 4dtzB-4nurA:
undetectable		 4dtzB-4nurA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 PHE A 113
ALA A 102
ALA A 234
LEU A 236
 None
 1.01A 4dtzB-4okdA:
undetectable		 4dtzB-4okdA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT

(Homo sapiens) 		PF12796
(Ank_2) 		4 ALA A 580
ALA A 588
PRO A 587
LEU A 547
 None
 1.09A 4dtzB-4ot9A:
undetectable		 4dtzB-4ot9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2b GLUTAMINE
AMINOACYL-TRNA
SYNTHETASE

(Toxoplasma
gondii) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 PHE A 541
ALA A 357
ALA A 481
PRO A 567
 None
 0.98A 4dtzB-4p2bA:
undetectable		 4dtzB-4p2bA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Psychromonas
ingrahamii) 		PF00464
(SHMT) 		4 PHE A  86
ALA A 210
LEU A 232
THR A 231
 None
None
CL  A 505 (-3.8A)
None
 1.13A 4dtzB-4p3mA:
undetectable		 4dtzB-4p3mA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		4 PHE A 761
ALA A 855
ALA A 861
THR A 860
 None
 1.02A 4dtzB-4ra7A:
undetectable		 4dtzB-4ra7A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 PHE A 297
ALA A 301
ALA A 449
THR A 454
 None
 1.08A 4dtzB-4uzsA:
undetectable		 4dtzB-4uzsA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		4 PHE A 103
ALA A 128
ALA A 158
LEU A 132
 None
 0.85A 4dtzB-4v2dA:
undetectable		 4dtzB-4v2dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		4 ALA A 293
ALA A 325
LEU A 285
THR A 286
 None
 0.98A 4dtzB-4w1wA:
undetectable		 4dtzB-4w1wA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaj MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR
RECEPTOR SUBFAMILY 2
GROUP E MEMBER 1

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 ALA A1313
ALA A1205
LEU A1209
THR A1208
 None
 1.06A 4dtzB-4xajA:
undetectable		 4dtzB-4xajA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr9 CALS8

(Micromonospora
echinospora) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 PHE A 196
ALA A 200
LEU A  31
THR A  30
 None
 1.13A 4dtzB-4xr9A:
undetectable		 4dtzB-4xr9A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		4 PHE A 210
ALA A 206
ALA A 154
LEU A 194
 None
 1.01A 4dtzB-4yj1A:
undetectable		 4dtzB-4yj1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE

(Sinorhizobium
meliloti) 		PF06253
(MTTB) 		4 ALA A 392
ALA A 170
PRO A 171
LEU A 413
 None
 1.09A 4dtzB-4yycA:
undetectable		 4dtzB-4yycA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxs VIRION EGRESS
PROTEIN UL31

(Human
alphaherpesvirus
1) 		PF02718
(Herpes_UL31) 		4 PHE B 219
ALA B 224
ALA B 245
LEU B 226
 None
 0.96A 4dtzB-4zxsB:
undetectable		 4dtzB-4zxsB:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbj FADH2-DEPENDENT
HALOGENASE PLTA

(Pseudomonas
protegens) 		no annotation 4 PHE E 211
ALA E 283
ALA E 216
LEU E 280
 None
 1.05A 4dtzB-5dbjE:
undetectable		 4dtzB-5dbjE:
20.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		4 ALA A 264
ALA A 328
PRO A 329
THR A 438
 HEM  A 501 (-3.6A)
HEM  A 501 ( 3.8A)
None
None
 0.52A 4dtzB-5e78A:
63.6		 4dtzB-5e78A:
98.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed7 TEGUMENT PROTEIN
UL21

(Human
alphaherpesvirus
1) 		PF03252
(Herpes_UL21) 		4 ALA A 461
PRO A 418
LEU A 482
THR A 483
 None
 0.93A 4dtzB-5ed7A:
undetectable		 4dtzB-5ed7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egi UNCHARACTERIZED
PROTEIN Y57A10A.10

(Caenorhabditis
elegans) 		PF05197
(TRIC) 		4 PHE A 228
ALA A 196
ALA A 164
THR A 160
 None
None
PT5  A 301 (-4.0A)
None
 1.08A 4dtzB-5egiA:
undetectable		 4dtzB-5egiA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fac ALANINE RACEMASE

(Streptomyces
coelicolor) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 PHE A 182
ALA A 185
PRO A 229
THR A 227
 None
 1.10A 4dtzB-5facA:
undetectable		 4dtzB-5facA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT

(Escherichia
coli) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 ALA C 127
ALA C  74
PRO C  75
THR A  55
 None
 1.08A 4dtzB-5g5gC:
undetectable		 4dtzB-5g5gC:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh3 OXYA PROTEIN

(Actinoplanes
teichomyceticus) 		PF00067
(p450) 		4 PHE A 136
ALA A 245
PRO A 364
LEU A 359
 None
 0.97A 4dtzB-5hh3A:
30.6		 4dtzB-5hh3A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 PHE A 358
ALA A 331
ALA A 317
LEU A 326
 None
 1.09A 4dtzB-5ijzA:
undetectable		 4dtzB-5ijzA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		4 ALA A 509
ALA A 443
PRO A 444
THR A 458
 None
 1.05A 4dtzB-5jwzA:
undetectable		 4dtzB-5jwzA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc7 CEREBELLIN-1

(Homo sapiens) 		PF00386
(C1q) 		4 PHE A 114
ALA A 167
ALA A 106
PRO A 107
 None
 1.02A 4dtzB-5kc7A:
undetectable		 4dtzB-5kc7A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		4 PHE A 114
ALA A 167
ALA A 106
PRO A 107
 None
 1.04A 4dtzB-5kcaA:
undetectable		 4dtzB-5kcaA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		4 PHE A 256
ALA A 309
ALA A 248
PRO A 249
 None
 1.05A 4dtzB-5kcaA:
undetectable		 4dtzB-5kcaA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwr CEREBELLIN-1

(Rattus
norvegicus) 		PF00386
(C1q) 		4 PHE A 114
ALA A 167
ALA A 106
PRO A 107
 None
 1.01A 4dtzB-5kwrA:
undetectable		 4dtzB-5kwrA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN9

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 PHE O  26
ALA O  18
ALA O  52
LEU O  57
 None
 1.08A 4dtzB-5mpdO:
undetectable		 4dtzB-5mpdO:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN9

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 PHE O  26
ALA O  18
LEU O  57
THR O  55
 None
 1.12A 4dtzB-5mpdO:
undetectable		 4dtzB-5mpdO:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nva PUTATIVE
SODIUM:SOLUTE
SYMPORTER

(Proteus
mirabilis) 		no annotation 4 ALA A 436
ALA A 477
PRO A 478
THR A 476
 None
 1.11A 4dtzB-5nvaA:
undetectable		 4dtzB-5nvaA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of2 SPORE
COAT-ASSOCIATED
PROTEIN N

(Bacillus
subtilis) 		no annotation 4 PHE A 191
ALA A 171
ALA A 230
THR A 231
 None
 1.13A 4dtzB-5of2A:
undetectable		 4dtzB-5of2A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnu DNA-DEPENDENT ATPASE
XPBII

(Sulfurisphaera
tokodaii) 		no annotation 4 PHE A 264
ALA A 294
ALA A 285
LEU A 281
 None
 1.14A 4dtzB-5tnuA:
undetectable		 4dtzB-5tnuA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 PHE A 402
ALA A 399
LEU A 294
THR A 398
 None
None
None
GOL  A 503 (-3.9A)
 1.11A 4dtzB-5tvjA:
undetectable		 4dtzB-5tvjA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2o J30 CCH

(Thermobacillus
composti) 		no annotation 4 ALA A  90
ALA A 530
PRO A 531
THR A 529
 None
 0.94A 4dtzB-5u2oA:
undetectable		 4dtzB-5u2oA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum) 		PF01547
(SBP_bac_1) 		4 PHE A 113
ALA A  93
PRO A  94
LEU A  84
 None
 0.95A 4dtzB-5u2pA:
undetectable		 4dtzB-5u2pA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uai METHIONYL-TRNA
FORMYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 PHE A 306
ALA A 244
PRO A 245
LEU A 287
 None
 0.92A 4dtzB-5uaiA:
undetectable		 4dtzB-5uaiA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH

(Brachybacterium
faecium) 		PF01636
(APH) 		4 PHE A 239
ALA A 258
ALA A 224
PRO A 223
 None
 0.96A 4dtzB-5uxbA:
undetectable		 4dtzB-5uxbA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Mus musculus) 		no annotation 4 PHE B 619
ALA B 592
ALA B 566
LEU B 563
 None
 1.10A 4dtzB-6bcqB:
undetectable		 4dtzB-6bcqB:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3

(Homo sapiens) 		no annotation 4 ALA A 218
ALA A 253
PRO A 252
LEU A 235
 None
NAP  A 401 (-3.4A)
None
None
 0.92A 4dtzB-6f2uA:
undetectable		 4dtzB-6f2uA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4a EXORIBONUCLEASE II,
MITOCHONDRIAL

([Candida]
glabrata) 		no annotation 4 ALA A 689
ALA A 760
PRO A 752
THR A 759
 None
 1.10A 4dtzB-6f4aA:
undetectable		 4dtzB-6f4aA:
11.88