SIMILAR PATTERNS OF AMINO ACIDS FOR 4DTZ_A_LDPA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		4 ALA A  41
ALA A 203
PRO A 202
THR A 283
 None
 0.97A 4dtzA-1c7jA:
0.0		 4dtzA-1c7jA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 PHE A 236
ALA A 436
ALA A 226
LEU A 427
 None
 1.01A 4dtzA-1d6mA:
0.0		 4dtzA-1d6mA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia) 		PF00390
(malic)
PF03949
(Malic_M) 		4 PHE A 309
ALA A 316
ALA A 284
THR A 283
 None
None
None
NAP  A1581 (-3.9A)
 1.02A 4dtzA-1gq2A:
0.0		 4dtzA-1gq2A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgn POLYADENYLATE-BINDIN
G PROTEIN 1

(Homo sapiens) 		PF00658
(PABP) 		4 ALA A  72
ALA A  40
LEU A  76
THR A  38
 None
 0.95A 4dtzA-1jgnA:
undetectable		 4dtzA-1jgnA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ALA A 320
PRO A 360
LEU A  55
THR A  56
 None
 0.90A 4dtzA-1jr1A:
undetectable		 4dtzA-1jr1A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 PHE A 603
ALA A 572
LEU A 585
THR A 574
 None
 0.95A 4dtzA-1k25A:
0.0		 4dtzA-1k25A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 PHE A 433
ALA A 519
LEU A 425
THR A 421
 None
 0.99A 4dtzA-1l5jA:
0.0		 4dtzA-1l5jA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyl GLUTAMINYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 PHE A 518
ALA A 344
PRO A 536
LEU A 507
 None
 0.97A 4dtzA-1nylA:
0.0		 4dtzA-1nylA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE

(Oryctolagus
cuniculus) 		PF00248
(Aldo_ket_red) 		4 ALA A 218
ALA A 253
PRO A 252
LEU A 235
 None
NDP  A1003 (-3.3A)
None
None
 0.86A 4dtzA-1q5mA:
0.0		 4dtzA-1q5mA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwy PEPTIDOGLYCAN
HYDROLASE

(Staphylococcus
aureus) 		PF01551
(Peptidase_M23) 		4 ALA A 209
ALA A 112
PRO A 111
THR A 113
 None
 0.90A 4dtzA-1qwyA:
undetectable		 4dtzA-1qwyA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdq TENASCIN-R

(Rattus
norvegicus) 		PF00041
(fn3) 		5 PHE A  90
ALA A  20
PRO A  66
LEU A  64
THR A  18
 None
 1.42A 4dtzA-1tdqA:
undetectable		 4dtzA-1tdqA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ten TENASCIN

(Homo sapiens) 		PF00041
(fn3) 		5 PHE A 889
ALA A 819
PRO A 865
LEU A 863
THR A 817
 None
 1.44A 4dtzA-1tenA:
undetectable		 4dtzA-1tenA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Thermotoga
maritima) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ALA A 290
PRO A 330
LEU A  30
THR A  31
 None
 0.96A 4dtzA-1vrdA:
undetectable		 4dtzA-1vrdA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdq BACTERIAL SULFITE
OXIDASE

(Escherichia
coli) 		PF00174
(Oxidored_molyb) 		5 PHE A  46
ALA A  60
ALA A 191
LEU A  63
THR A  65
 MTE  A 301 (-4.7A)
None
None
None
None
 1.25A 4dtzA-1xdqA:
undetectable		 4dtzA-1xdqA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdq BACTERIAL SULFITE
OXIDASE

(Escherichia
coli) 		PF00174
(Oxidored_molyb) 		5 PHE A  46
ALA A  60
ALA A 191
PRO A 192
LEU A  63
 MTE  A 301 (-4.7A)
None
None
None
None
 1.11A 4dtzA-1xdqA:
undetectable		 4dtzA-1xdqA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkd ISOCITRATE
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00180
(Iso_dh) 		4 ALA A 305
ALA A 248
LEU A 212
THR A 209
 None
 0.93A 4dtzA-1xkdA:
undetectable		 4dtzA-1xkdA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Homo sapiens) 		PF00698
(Acyl_transf_1) 		4 PHE A 121
ALA A 138
ALA A 143
LEU A 245
 None
 0.87A 4dtzA-2c2nA:
undetectable		 4dtzA-2c2nA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ck2 HUMAN FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		5 PHE A  92
ALA A  18
PRO A  64
LEU A  62
THR A  16
 None
 1.39A 4dtzA-2ck2A:
undetectable		 4dtzA-2ck2A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 ALA A 218
ALA A 253
PRO A 252
LEU A 235
 None
NAP  A1001 (-3.4A)
None
None
 0.99A 4dtzA-2fvlA:
undetectable		 4dtzA-2fvlA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE

(Bacillus
halodurans) 		PF02608
(Bmp) 		4 PHE A 168
ALA A 193
ALA A 201
THR A 215
 None
 0.96A 4dtzA-2hqbA:
undetectable		 4dtzA-2hqbA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7a CALPAIN 13

(Homo sapiens) 		no annotation 4 PHE A 634
ALA A 595
LEU A 602
THR A 599
 None
 1.02A 4dtzA-2i7aA:
undetectable		 4dtzA-2i7aA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 ALA A 218
ALA A 253
PRO A 252
LEU A 235
 None
NAP  A   1 (-3.5A)
BME  A 327 (-4.5A)
None
 0.92A 4dtzA-2ipjA:
undetectable		 4dtzA-2ipjA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		4 PHE A 295
ALA A  34
ALA A 277
LEU A  21
 None
 0.79A 4dtzA-2isqA:
undetectable		 4dtzA-2isqA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)

(Homo sapiens) 		no annotation 4 PHE A 115
ALA A  86
PRO A  90
LEU A 163
 None
 0.99A 4dtzA-2jdxA:
undetectable		 4dtzA-2jdxA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jll NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		5 PHE A 586
ALA A 512
PRO A 561
LEU A 559
THR A 510
 None
 1.40A 4dtzA-2jllA:
undetectable		 4dtzA-2jllA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oce HYPOTHETICAL PROTEIN
PA5201

(Pseudomonas
aeruginosa) 		PF00575
(S1)
PF09371
(Tex_N)
PF12836
(HHH_3)
PF16921
(Tex_YqgF) 		5 PHE A 637
ALA A 326
ALA A 388
LEU A 386
THR A 331
 None
 1.41A 4dtzA-2oceA:
undetectable		 4dtzA-2oceA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 298
ALA A 302
ALA A 327
LEU A 312
 None
 0.97A 4dtzA-2og9A:
undetectable		 4dtzA-2og9A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozg GCN5-RELATED
N-ACETYLTRANSFERASE

(Trichormus
variabilis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 ALA A 120
PRO A 119
LEU A 124
THR A 121
 COA  A 500 (-3.1A)
None
COA  A 500 (-3.5A)
COA  A 500 (-3.1A)
 0.91A 4dtzA-2ozgA:
undetectable		 4dtzA-2ozgA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		4 PHE A 176
ALA A 235
ALA A 218
PRO A 219
 None
 0.68A 4dtzA-2qa2A:
undetectable		 4dtzA-2qa2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb8 TENASCIN

(Homo sapiens) 		PF00041
(fn3) 		5 PHE A 889
ALA A 819
PRO A 865
LEU A 863
THR A 817
 None
 1.41A 4dtzA-2rb8A:
undetectable		 4dtzA-2rb8A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		4 PHE A 586
ALA A 332
ALA A 528
PRO A 527
 None
 0.99A 4dtzA-2vobA:
undetectable		 4dtzA-2vobA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsr CATECHOL 1,2
DIOXYGENASE

(Acinetobacter
radioresistens) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 PHE A 236
ALA A 187
LEU A 131
THR A 189
 None
 1.02A 4dtzA-2xsrA:
undetectable		 4dtzA-2xsrA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyc NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		5 PHE A 586
ALA A 512
PRO A 561
LEU A 559
THR A 510
 None
 1.40A 4dtzA-2xycA:
undetectable		 4dtzA-2xycA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypf AVRBS3

(Xanthomonas
campestris) 		PF03377
(TAL_effector) 		4 ALA A 340
ALA A 306
LEU A 341
THR A 309
 None
 0.94A 4dtzA-2ypfA:
undetectable		 4dtzA-2ypfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypf AVRBS3

(Xanthomonas
campestris) 		PF03377
(TAL_effector) 		4 ALA A 408
ALA A 374
LEU A 409
THR A 377
 None
 0.95A 4dtzA-2ypfA:
undetectable		 4dtzA-2ypfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypf AVRBS3

(Xanthomonas
campestris) 		PF03377
(TAL_effector) 		4 ALA A 442
ALA A 408
LEU A 443
THR A 411
 None
 0.86A 4dtzA-2ypfA:
undetectable		 4dtzA-2ypfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b83 TEN-D3

(Homo sapiens) 		PF00041
(fn3) 		5 PHE A  87
ALA A  17
PRO A  63
LEU A  61
THR A  15
 None
 1.40A 4dtzA-3b83A:
undetectable		 4dtzA-3b83A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw2 2-NITROPROPANE
DIOXYGENASE

(Streptomyces
ansochromogenes) 		PF03060
(NMO) 		4 ALA A 318
ALA A 275
PRO A 274
THR A 267
 None
 0.99A 4dtzA-3bw2A:
undetectable		 4dtzA-3bw2A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N) 		4 ALA A 135
ALA A  14
PRO A  15
LEU A 163
 None
 0.90A 4dtzA-3d4jA:
undetectable		 4dtzA-3d4jA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbk ELASTASE

(Pseudomonas
aeruginosa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 PHE A 248
ALA A 173
ALA A 139
LEU A  86
 None
 0.88A 4dtzA-3dbkA:
undetectable		 4dtzA-3dbkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxq CHOLINE/ETHANOLAMINE
KINASE FAMILY
PROTEIN

(Mesorhizobium
loti) 		PF01633
(Choline_kinase) 		4 PHE A 123
ALA A 174
ALA A  67
LEU A 116
 None
 1.01A 4dtzA-3dxqA:
undetectable		 4dtzA-3dxqA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egj N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Vibrio cholerae) 		PF01979
(Amidohydro_1) 		4 PHE A  55
ALA A 332
ALA A 313
THR A 317
 None
 1.02A 4dtzA-3egjA:
undetectable		 4dtzA-3egjA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Mus musculus) 		PF00288
(GHMP_kinases_N) 		4 ALA A 135
ALA A  14
PRO A  15
LEU A 163
 None
 0.89A 4dtzA-3f0nA:
undetectable		 4dtzA-3f0nA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)

(Oryza sativa) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 PHE A 463
ALA A 387
ALA A 540
THR A 543
 SO4  A 597 (-3.6A)
None
None
None
 1.02A 4dtzA-3fr8A:
undetectable		 4dtzA-3fr8A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftp 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		4 ALA A 161
ALA A 185
PRO A 186
THR A 142
 None
 1.00A 4dtzA-3ftpA:
undetectable		 4dtzA-3ftpA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM

(Serratia
plymuthica) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 PHE A 524
ALA A 364
LEU A 368
THR A 367
 EDO  A8008 ( 4.8A)
None
None
None
 0.98A 4dtzA-3gbdA:
undetectable		 4dtzA-3gbdA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3guw UNCHARACTERIZED
PROTEIN AF_1765

(Archaeoglobus
fulgidus) 		PF01026
(TatD_DNase) 		4 ALA A  69
PRO A  56
LEU A  51
THR A  52
 None
 1.01A 4dtzA-3guwA:
undetectable		 4dtzA-3guwA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Mus musculus) 		PF00155
(Aminotran_1_2) 		4 ALA A 113
ALA A 290
LEU A 273
THR A 292
 None
 0.95A 4dtzA-3hlmA:
undetectable		 4dtzA-3hlmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		4 ALA A 523
PRO A 524
LEU A 488
THR A 458
 None
 0.88A 4dtzA-3j9dA:
undetectable		 4dtzA-3j9dA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke5 HYPOTHETICAL
CYTOSOLIC PROTEIN

(Bacillus cereus) 		PF01923
(Cob_adeno_trans) 		4 PHE A 160
ALA A 163
ALA A 103
PRO A 104
 None
 1.03A 4dtzA-3ke5A:
undetectable		 4dtzA-3ke5A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl0 GLUCURONOXYLANASE
XYNC

(Bacillus
subtilis) 		PF17189
(Glyco_hydro_30C) 		4 PHE A 375
ALA A 377
ALA A 329
THR A 385
 None
MLA  A 403 ( 4.5A)
None
None
 0.95A 4dtzA-3kl0A:
undetectable		 4dtzA-3kl0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu INTEGRIN-LINKED
KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 PHE A 235
ALA A 256
ALA A 262
PRO A 263
 None
 1.02A 4dtzA-3kmuA:
undetectable		 4dtzA-3kmuA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 ALA A 218
ALA A 253
PRO A 252
LEU A 235
 NAD  A 327 (-4.9A)
NAD  A 327 (-3.4A)
None
None
 0.94A 4dtzA-3ln3A:
undetectable		 4dtzA-3ln3A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		4 ALA A  64
ALA A 197
PRO A 198
LEU A 312
 None
 0.78A 4dtzA-3mzvA:
undetectable		 4dtzA-3mzvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnd POSSIBLE SUBSTRATE
BINDING PROTEIN OF
ABC TRANSPORTER
SYSTEM

(Rhodopseudomonas
palustris) 		no annotation 4 ALA B  94
ALA B 115
PRO B 114
THR B  90
 None
 0.98A 4dtzA-3nndB:
undetectable		 4dtzA-3nndB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oo3 OXY PROTEIN

(Actinoplanes
teichomyceticus) 		PF00067
(p450) 		4 PHE A 130
ALA A 134
ALA A 345
LEU A 118
 None
 0.94A 4dtzA-3oo3A:
31.9		 4dtzA-3oo3A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		5 PHE A 533
ALA A 541
ALA A 577
LEU A 520
THR A 521
 None
 1.43A 4dtzA-3opbA:
undetectable		 4dtzA-3opbA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua) 		PF00294
(PfkB) 		4 PHE A  50
ALA A 259
ALA A 274
THR A 270
 None
 0.89A 4dtzA-3q1yA:
undetectable		 4dtzA-3q1yA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 377
ALA A 381
ALA A 367
PRO A 368
 None
 1.00A 4dtzA-3q4tA:
undetectable		 4dtzA-3q4tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmw THIOESTERASE

(Streptomyces
coelicolor) 		PF00975
(Thioesterase) 		4 ALA A  89
ALA A 125
PRO A 126
THR A  98
 None
 0.94A 4dtzA-3qmwA:
undetectable		 4dtzA-3qmwA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2

(Rattus
norvegicus) 		PF01070
(FMN_dh) 		4 ALA A 325
ALA A  70
PRO A  71
THR A  59
 None
 0.83A 4dtzA-3sgzA:
undetectable		 4dtzA-3sgzA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PHE A 701
ALA A 709
LEU A 730
THR A 732
 None
 0.91A 4dtzA-3sunA:
undetectable		 4dtzA-3sunA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugm TAL EFFECTOR
AVRBS3/PTHA

(Xanthomonas
oryzae) 		PF03377
(TAL_effector) 		4 ALA A 883
ALA A 849
LEU A 884
THR A 852
 None
 0.90A 4dtzA-3ugmA:
undetectable		 4dtzA-3ugmA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vot L-AMINO ACID LIGASE,
BL00235

(Bacillus
licheniformis) 		PF13535
(ATP-grasp_4) 		4 PHE A  76
ALA A   9
ALA A  94
THR A  90
 None
 1.00A 4dtzA-3votA:
undetectable		 4dtzA-3votA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw5 CELLOBIOSE
2-EPIMERASE

(Ruminococcus
albus) 		PF07221
(GlcNAc_2-epim) 		4 PHE A  56
ALA A  60
LEU A  10
THR A  11
 None
 1.02A 4dtzA-3vw5A:
undetectable		 4dtzA-3vw5A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		4 PHE A 639
ALA A 628
ALA A 488
LEU A 486
 None
 0.98A 4dtzA-3wstA:
undetectable		 4dtzA-3wstA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxs CRYPTOCHROME B

(Rhodobacter
sphaeroides) 		PF04244
(DPRP) 		4 PHE A 372
ALA A 376
PRO A 335
LEU A 502
 None
 0.92A 4dtzA-3zxsA:
undetectable		 4dtzA-3zxsA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7l MYOSIN IE HEAVY
CHAIN

(Dictyostelium
discoideum) 		PF00063
(Myosin_head) 		4 PHE C 146
ALA C 252
LEU C 256
THR C 255
 None
 0.94A 4dtzA-4a7lC:
undetectable		 4dtzA-4a7lC:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00291
(PALP) 		4 PHE A 403
ALA A 142
ALA A 385
LEU A 129
 None
 0.79A 4dtzA-4aecA:
undetectable		 4dtzA-4aecA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA

(Dictyostelium
discoideum) 		PF01267
(F-actin_cap_A) 		4 ALA A  11
ALA A  44
LEU A  15
THR A  47
 None
 1.02A 4dtzA-4akrA:
undetectable		 4dtzA-4akrA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		4 PHE A 685
ALA A 611
ALA A 561
LEU A 613
 None
 1.02A 4dtzA-4c4aA:
undetectable		 4dtzA-4c4aA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cx9 CYTOCHROME C, CLASS
II

(Shewanella
frigidimarina) 		PF01322
(Cytochrom_C_2) 		4 PHE A  41
ALA A  45
ALA A 110
THR A 114
 None
 0.78A 4dtzA-4cx9A:
undetectable		 4dtzA-4cx9A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE

(Polaromonas sp.
JS666) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 PHE A 106
ALA A 111
ALA A 140
LEU A 138
 None
 1.00A 4dtzA-4dllA:
undetectable		 4dtzA-4dllA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48

(Caldicellulosiruptor
bescii) 		PF02011
(Glyco_hydro_48) 		4 ALA A 503
ALA A 623
LEU A 505
THR A 626
 None
 0.85A 4dtzA-4el8A:
undetectable		 4dtzA-4el8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmv GLUCURONOARABINOXYLA
N
ENDO-1,4-BETA-XYLANA
SE

([Clostridium]
papyrosolvens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 PHE A 372
ALA A 374
ALA A 326
THR A 382
 None
 0.92A 4dtzA-4fmvA:
undetectable		 4dtzA-4fmvA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ALA A 296
PRO A 336
LEU A  36
THR A  37
 None
 0.91A 4dtzA-4fxsA:
undetectable		 4dtzA-4fxsA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 PHE A 272
ALA A 305
ALA A 245
THR A 249
 None
 0.74A 4dtzA-4htgA:
undetectable		 4dtzA-4htgA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH) 		4 ALA A 296
PRO A 336
LEU A  36
THR A  37
 None
 0.94A 4dtzA-4ix2A:
undetectable		 4dtzA-4ix2A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixw HALOHYDRIN
DEHALOGENASE

(Agrobacterium
tumefaciens) 		PF13561
(adh_short_C2) 		4 ALA A 150
ALA A 174
PRO A 175
THR A 131
 None
None
IXW  A 302 (-4.6A)
None
 0.71A 4dtzA-4ixwA:
undetectable		 4dtzA-4ixwA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Campylobacter
jejuni) 		PF00478
(IMPDH) 		4 ALA A 290
PRO A 330
LEU A  33
THR A  34
 None
 0.91A 4dtzA-4mz1A:
undetectable		 4dtzA-4mz1A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 PHE A 113
ALA A 102
ALA A 234
LEU A 236
 None
 1.01A 4dtzA-4okdA:
undetectable		 4dtzA-4okdA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2b GLUTAMINE
AMINOACYL-TRNA
SYNTHETASE

(Toxoplasma
gondii) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 PHE A 541
ALA A 357
ALA A 481
PRO A 567
 None
 0.98A 4dtzA-4p2bA:
undetectable		 4dtzA-4p2bA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaw XYN30D

(Paenibacillus
barcinonensis) 		PF03422
(CBM_6)
PF17189
(Glyco_hydro_30C) 		4 PHE A 374
ALA A 376
ALA A 328
THR A 384
 None
 0.99A 4dtzA-4qawA:
undetectable		 4dtzA-4qawA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qr8 XAA-PRO DIPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		4 ALA A 322
ALA A 306
LEU A 328
THR A 329
 None
 1.00A 4dtzA-4qr8A:
undetectable		 4dtzA-4qr8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		4 PHE A 761
ALA A 855
ALA A 861
THR A 860
 None
 1.02A 4dtzA-4ra7A:
undetectable		 4dtzA-4ra7A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhm ARGINASE

(Trypanosoma
brucei) 		PF00491
(Arginase) 		4 ALA A 231
ALA A 287
LEU A 283
THR A 284
 None
 0.98A 4dtzA-4rhmA:
undetectable		 4dtzA-4rhmA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		4 PHE A 103
ALA A 128
ALA A 158
LEU A 132
 None
 0.83A 4dtzA-4v2dA:
undetectable		 4dtzA-4v2dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		4 ALA A 293
ALA A 325
LEU A 285
THR A 286
 None
 0.98A 4dtzA-4w1wA:
undetectable		 4dtzA-4w1wA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis) 		PF01494
(FAD_binding_3) 		4 PHE A 176
ALA A 235
ALA A 218
PRO A 219
 None
 0.79A 4dtzA-4x4jA:
undetectable		 4dtzA-4x4jA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 ALA A 116
ALA A 100
LEU A 104
THR A 103
 None
 1.00A 4dtzA-4xriA:
undetectable		 4dtzA-4xriA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxs VIRION EGRESS
PROTEIN UL31

(Human
alphaherpesvirus
1) 		PF02718
(Herpes_UL31) 		4 PHE B 219
ALA B 224
ALA B 245
LEU B 226
 None
 0.97A 4dtzA-4zxsB:
undetectable		 4dtzA-4zxsB:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00478
(IMPDH) 		4 ALA A 293
PRO A 333
LEU A  34
THR A  35
 None
 0.95A 4dtzA-5ahmA:
undetectable		 4dtzA-5ahmA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ALA A 293
PRO A 333
LEU A  34
THR A  35
 None
 0.95A 4dtzA-5ahnA:
undetectable		 4dtzA-5ahnA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd6 TPR-DOMAIN
CONTAINING PROTEIN

(Parabacteroides
distasonis) 		PF17128
(DUF5107) 		4 ALA A 417
ALA A 394
PRO A 395
LEU A 381
 None
 0.85A 4dtzA-5cd6A:
undetectable		 4dtzA-5cd6A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum) 		no annotation 4 ALA B 580
ALA B   8
PRO B   9
LEU B 578
 None
 0.92A 4dtzA-5cwwB:
undetectable		 4dtzA-5cwwB:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum) 		no annotation 4 PHE B  22
ALA B 580
ALA B   8
LEU B 578
 None
 0.80A 4dtzA-5cwwB:
undetectable		 4dtzA-5cwwB:
22.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		4 ALA A 264
ALA A 328
PRO A 329
THR A 438
 HEM  A 501 (-3.6A)
HEM  A 501 ( 3.8A)
None
None
 0.53A 4dtzA-5e78A:
63.7		 4dtzA-5e78A:
98.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ALA A 256
ALA A 282
PRO A 286
THR A 283
 None
 1.01A 4dtzA-5e7qA:
undetectable		 4dtzA-5e7qA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed7 TEGUMENT PROTEIN
UL21

(Human
alphaherpesvirus
1) 		PF03252
(Herpes_UL21) 		4 ALA A 461
PRO A 418
LEU A 482
THR A 483
 None
 0.94A 4dtzA-5ed7A:
undetectable		 4dtzA-5ed7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hd2 PARASPORAL CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		4 PHE A 122
ALA A 284
LEU A 286
THR A 285
 None
 1.02A 4dtzA-5hd2A:
undetectable		 4dtzA-5hd2A:
18.98