SIMILAR PATTERNS OF AMINO ACIDS FOR 4DTA_B_ADNB401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri) 		PF01804
(Penicil_amidase) 		4 PRO B 232
ILE B 188
LEU B   5
ILE B 237
 None
 0.79A 4dtaB-1cp9B:
2.3		 4dtaB-1cp9B:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 ILE A 146
ILE A 182
LEU A 186
ASP A 139
 None
 0.96A 4dtaB-1dq3A:
undetectable		 4dtaB-1dq3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU) 		4 PRO A 240
ILE A 287
ILE A  63
ASP A  61
 None
 0.91A 4dtaB-1iwpA:
undetectable		 4dtaB-1iwpA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jih DNA POLYMERASE ETA

(Saccharomyces
cerevisiae) 		PF00817
(IMS)
PF11799
(IMS_C) 		4 ILE A 190
PRO A 209
ILE A 208
ILE A 212
 None
 0.83A 4dtaB-1jihA:
undetectable		 4dtaB-1jihA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I

(Escherichia
coli) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ILE A 344
ILE A 261
LEU A 357
ILE A 268
 None
 0.90A 4dtaB-1k0gA:
undetectable		 4dtaB-1k0gA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 ILE A 303
ILE A 285
LEU A 278
ILE A 254
 None
 0.88A 4dtaB-1k32A:
undetectable		 4dtaB-1k32A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lmo LYSOZYME

(Oncorhynchus
mykiss) 		PF00062
(Lys) 		4 SER A  15
ILE A  92
ILE A  55
ASP A  87
 None
 0.95A 4dtaB-1lmoA:
undetectable		 4dtaB-1lmoA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lsh LIPOVITELLIN (LV-1N,
LV-1C)

(Ichthyomyzon
unicuspis) 		PF01347
(Vitellogenin_N)
PF09172
(DUF1943) 		4 SER A 591
ILE A 609
LYS A 610
ASP A 617
 None
 0.92A 4dtaB-1lshA:
undetectable		 4dtaB-1lshA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw1 CHOLINE KINASE (49.2
KD)

(Caenorhabditis
elegans) 		PF01633
(Choline_kinase) 		4 PRO A 139
ILE A 154
LEU A 262
ILE A 300
 None
 0.63A 4dtaB-1nw1A:
13.4		 4dtaB-1nw1A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sw6 REGULATORY PROTEIN
SWI6

(Saccharomyces
cerevisiae) 		PF00023
(Ank)
PF13857
(Ank_5) 		4 ILE A 427
LEU A 450
ILE A 214
ASP A 375
 None
 0.87A 4dtaB-1sw6A:
undetectable		 4dtaB-1sw6A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t00 THIOREDOXIN

(Streptomyces
coelicolor) 		PF00085
(Thioredoxin) 		4 ILE A  91
PRO A  77
LEU A  43
ILE A  39
 None
 0.94A 4dtaB-1t00A:
undetectable		 4dtaB-1t00A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU) 		4 PRO A 239
ILE A 286
ILE A  62
ASP A  60
 None
 0.88A 4dtaB-1uc4A:
undetectable		 4dtaB-1uc4A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynq OXIDOREDUCTASE

(Bacillus
halodurans) 		PF00248
(Aldo_ket_red) 		4 SER A 163
ILE A 165
ILE A 186
ILE A 156
 None
 0.94A 4dtaB-1ynqA:
undetectable		 4dtaB-1ynqA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zao RIO2 SERINE KINASE

(Archaeoglobus
fulgidus) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		4 PRO A 167
ILE A 182
LEU A 225
ILE A 234
 ATP  A 286 ( 4.7A)
ATP  A 286 (-4.2A)
None
ATP  A 286 (-4.5A)
 0.57A 4dtaB-1zaoA:
10.9		 4dtaB-1zaoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbe COAT PROTEIN VP1

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 ILE 1  42
ILE 1  78
LEU 1  76
ILE 1  51
 None
 0.87A 4dtaB-1zbe1:
undetectable		 4dtaB-1zbe1:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbr CONSERVED
HYPOTHETICAL PROTEIN

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		4 SER A  92
ILE A  52
LEU A 130
ILE A 340
 None
 0.85A 4dtaB-1zbrA:
undetectable		 4dtaB-1zbrA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5x BUGD

(Bordetella
pertussis) 		PF03401
(TctC) 		4 SER A 216
ILE A 114
LEU A 146
ILE A 103
 None
 0.94A 4dtaB-2f5xA:
undetectable		 4dtaB-2f5xA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iew INOSITOL
POLYPHOSPHATE
MULTIKINASE

(Saccharomyces
cerevisiae) 		PF03770
(IPK) 		4 ILE A  29
PRO A  67
LEU A 260
ILE A 324
 None
 0.69A 4dtaB-2iewA:
3.7		 4dtaB-2iewA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjx URIDYLATE KINASE

(Bacillus
anthracis) 		PF00696
(AA_kinase) 		4 ILE A   9
ILE A 129
LEU A  86
ILE A  50
 None
 0.96A 4dtaB-2jjxA:
undetectable		 4dtaB-2jjxA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k2i CENTRIN-2

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 ILE A 165
ILE A 146
LEU A 126
ILE A 121
 None
 0.84A 4dtaB-2k2iA:
undetectable		 4dtaB-2k2iA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3d LIN0334 PROTEIN

(Listeria
innocua) 		PF07252
(DUF1433) 		4 SER A  73
ILE A  29
LEU A  25
ILE A  53
 None
 0.96A 4dtaB-2k3dA:
2.8		 4dtaB-2k3dA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pm9 PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 SER A 178
ILE A 133
LEU A 190
ILE A 135
 None
 0.94A 4dtaB-2pm9A:
undetectable		 4dtaB-2pm9A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppq HOMOSERINE KINASE

(Agrobacterium
fabrum) 		PF01636
(APH) 		4 ILE A  49
PRO A  80
ILE A 210
ASP A 211
 None
None
None
PO4  A 401 (-3.2A)
 0.39A 4dtaB-2ppqA:
17.8		 4dtaB-2ppqA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkj TYROSYL-TRNA
SYNTHETASE

(Neurospora
crassa) 		PF00579
(tRNA-synt_1b) 		4 ILE A 196
ILE A 166
LEU A 109
ILE A 102
 C  C  65 ( 4.2A)
None
None
None
 0.78A 4dtaB-2rkjA:
undetectable		 4dtaB-2rkjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rtx PEPTIDYL-TRNA
HYDROLASE YAEJ

(Escherichia
coli) 		PF00472
(RF-1) 		4 SER A  46
ILE A  43
LEU A  91
ILE A  95
 None
 0.83A 4dtaB-2rtxA:
undetectable		 4dtaB-2rtxA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk9 ALPHA-TOXIN

(Clostridium
novyi) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 SER A 461
ILE A 456
LEU A 412
ILE A 416
 None
 0.87A 4dtaB-2vk9A:
undetectable		 4dtaB-2vk9A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22)
PF01163
(RIO1) 		4 ILE A 358
PRO A 399
ILE A 416
ILE A 466
 None
 0.70A 4dtaB-2vwbA:
8.9		 4dtaB-2vwbA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxe CG10686-PA

(Drosophila
melanogaster) 		PF12701
(LSM14) 		4 ILE A  75
LEU A  14
ILE A  72
ASP A  71
 None
 0.93A 4dtaB-2vxeA:
undetectable		 4dtaB-2vxeA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y27 PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		4 ILE A 159
ILE A 181
LEU A 207
ILE A 173
 None
 0.90A 4dtaB-2y27A:
undetectable		 4dtaB-2y27A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykq LINE-1 ORF1P

(Homo sapiens) 		PF02994
(Transposase_22)
PF17489
(Tnp_22_trimer)
PF17490
(Tnp_22_dsRBD) 		4 ILE A 217
ILE A 247
LEU A 242
ILE A 181
 None
 0.89A 4dtaB-2ykqA:
undetectable		 4dtaB-2ykqA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ILE A 435
ILE A 461
LEU A 482
ILE A 458
 None
 0.87A 4dtaB-3ciyA:
undetectable		 4dtaB-3ciyA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3e UNCHARACTERIZED
PROTEIN TM1679

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		4 ILE A 205
LEU A 197
ILE A 208
ASP A 174
 None
 0.93A 4dtaB-3h3eA:
undetectable		 4dtaB-3h3eA:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Enterococcus
faecium) 		PF01636
(APH) 		4 PRO A  73
ILE A  88
ILE A 209
ASP A 210
 None
 0.47A 4dtaB-3hamA:
21.4		 4dtaB-3hamA:
34.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvn HEMOLYSIN

(Streptococcus
suis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 ILE A 319
ILE A 342
LEU A 338
ILE A 276
 None
 0.94A 4dtaB-3hvnA:
undetectable		 4dtaB-3hvnA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imm PUTATIVE SECRETED
GLYCOSYLHYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		4 ILE A 148
ILE A 219
LEU A  31
ILE A 201
 None
 0.90A 4dtaB-3immA:
undetectable		 4dtaB-3immA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9h PF-32 PROTEIN

(Borreliella
burgdorferi) 		PF13614
(AAA_31) 		4 SER A 116
ILE A  71
LEU A  38
ILE A  40
 None
 0.85A 4dtaB-3k9hA:
undetectable		 4dtaB-3k9hA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks2 CHAPERONE PROTEIN
IPGC

(Shigella
flexneri) 		PF07720
(TPR_3) 		4 ILE A 131
LYS A 140
ILE A 141
ASP A 148
 None
 0.94A 4dtaB-3ks2A:
undetectable		 4dtaB-3ks2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mes CHOLINE KINASE

(Cryptosporidium
parvum) 		PF01633
(Choline_kinase) 		4 PRO A 137
ILE A 152
LEU A 275
ILE A 284
 ADP  A 425 ( 4.7A)
ADP  A 425 (-4.4A)
None
None
 0.54A 4dtaB-3mesA:
15.9		 4dtaB-3mesA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mru AMINOACYL-HISTIDINE
DIPEPTIDASE

(Vibrio
alginolyticus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ILE A 100
ILE A  26
LEU A  36
ILE A  23
 None
 0.92A 4dtaB-3mruA:
undetectable		 4dtaB-3mruA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE

(Vibrio
parahaemolyticus) 		PF00171
(Aldedh) 		4 ILE A 107
ILE A 135
LEU A 181
ILE A 187
 None
 0.96A 4dtaB-3my7A:
undetectable		 4dtaB-3my7A:
19.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n4t APH(2'')-ID

(Enterococcus
casseliflavus) 		PF01636
(APH) 		8 SER A  28
ILE A  44
PRO A  76
LYS A  97
ILE A  98
LEU A 204
ILE A 216
ASP A 217
 None
 0.50A 4dtaB-3n4tA:
42.7		 4dtaB-3n4tA:
99.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nda SERPIN-2

(Ixodes ricinus) 		PF00079
(Serpin) 		4 ILE A 100
ILE A 338
LEU A 310
ILE A 305
 None
 0.90A 4dtaB-3ndaA:
undetectable		 4dtaB-3ndaA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwj ATSK2

(Arabidopsis
thaliana) 		PF01202
(SKI) 		4 ILE A 278
ILE A 276
LEU A 271
ILE A 259
 None
 0.94A 4dtaB-3nwjA:
undetectable		 4dtaB-3nwjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB

(Thermus
thermophilus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 SER A 167
ILE A 182
LEU A 178
ILE A 227
 None
 0.86A 4dtaB-3oa0A:
undetectable		 4dtaB-3oa0A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 ILE B 432
ILE B 463
LEU B 410
ILE B 396
 None
 0.91A 4dtaB-3ohmB:
undetectable		 4dtaB-3ohmB:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 ILE A   9
PRO A  57
LEU A  43
ILE A  60
 None
 0.96A 4dtaB-3osqA:
undetectable		 4dtaB-3osqA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A  62
LEU A  67
ILE A  75
ASP A  72
 None
 0.88A 4dtaB-3oytA:
undetectable		 4dtaB-3oytA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg7 NEUROFIBROMIN

(Homo sapiens) 		PF13716
(CRAL_TRIO_2) 		4 ILE A1805
ILE A1769
LEU A1779
ILE A1766
 None
 0.94A 4dtaB-3pg7A:
undetectable		 4dtaB-3pg7A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Coccidioides
immitis) 		PF01116
(F_bP_aldolase) 		4 PRO A  56
ILE A  59
ILE A  93
ASP A  90
 IOD  A 303 ( 4.6A)
None
IOD  A 304 (-4.2A)
None
 0.83A 4dtaB-3pm6A:
undetectable		 4dtaB-3pm6A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q33 HISTONE
ACETYLTRANSFERASE
RTT109

(Saccharomyces
cerevisiae) 		PF08214
(HAT_KAT11) 		4 SER A  54
ILE A 365
LEU A 387
ILE A 361
 None
 0.74A 4dtaB-3q33A:
undetectable		 4dtaB-3q33A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ILE A 794
LYS A 743
ILE A 744
ILE A 783
 None
 0.93A 4dtaB-3qdeA:
undetectable		 4dtaB-3qdeA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE

(Alteromonas
macleodii) 		PF00557
(Peptidase_M24) 		4 ILE A 323
ILE A 309
LEU A 387
ILE A 306
 None
 0.95A 4dtaB-3rvaA:
undetectable		 4dtaB-3rvaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 ILE A 267
ILE A 242
LEU A 219
ILE A 229
 None
 0.91A 4dtaB-3sucA:
undetectable		 4dtaB-3sucA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdw GENTAMICIN
RESISTANCE PROTEIN

(Enterococcus
gallinarum) 		PF01636
(APH) 		4 PRO A  75
LYS A  94
LEU A 203
ILE A 217
 None
GDP  A 500 (-4.3A)
None
GDP  A 500 ( 4.1A)
 0.63A 4dtaB-3tdwA:
30.0		 4dtaB-3tdwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v30 DNA-BINDING PROTEIN
RFXANK

(Homo sapiens) 		PF12796
(Ank_2)
PF13606
(Ank_3) 		4 SER A 159
ILE A 185
ILE A 183
LEU A 209
 None
 0.86A 4dtaB-3v30A:
undetectable		 4dtaB-3v30A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zk4 DIPHOSPHONUCLEOTIDE
PHOSPHATASE 1

(Lupinus luteus) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 SER A  96
ILE A  25
LEU A 122
ILE A  57
 None
 0.87A 4dtaB-3zk4A:
undetectable		 4dtaB-3zk4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bej DYNAMIN 1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 SER A 428
ILE A 636
LEU A 491
ILE A 421
 None
 0.92A 4dtaB-4bejA:
2.7		 4dtaB-4bejA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bp8 OLIGOPEPTIDASE B

(Trypanosoma
brucei) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 SER A 193
ILE A 206
ILE A 255
LEU A 253
 None
 0.94A 4dtaB-4bp8A:
undetectable		 4dtaB-4bp8A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzk PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12931
(Sec16_C) 		4 SER A 178
ILE A 133
LEU A 190
ILE A 135
 None
 0.94A 4dtaB-4bzkA:
undetectable		 4dtaB-4bzkA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cn8 PROXIMAL THREAD
MATRIX PROTEIN 1

(Mytilus
galloprovincialis) 		PF00092
(VWA) 		4 PRO A 182
ILE A 213
LEU A 170
ILE A 141
 None
 0.83A 4dtaB-4cn8A:
undetectable		 4dtaB-4cn8A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo sapiens) 		PF00621
(RhoGEF) 		4 SER A2067
ILE A2078
ILE A2060
ASP A2083
 None
 0.84A 4dtaB-4d0oA:
undetectable		 4dtaB-4d0oA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0p COP9 SIGNALOSOME
COMPLEX SUBUNIT 4

(Homo sapiens) 		PF01399
(PCI) 		4 LYS A 290
ILE A 299
LEU A 235
ASP A 196
 None
 0.96A 4dtaB-4d0pA:
undetectable		 4dtaB-4d0pA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN

(Xanthomonas
euvesicatoria) 		PF13855
(LRR_8) 		4 PRO A 416
ILE A 419
LEU A 422
ILE A 395
 None
 0.96A 4dtaB-4fcgA:
undetectable		 4dtaB-4fcgA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP1

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 ILE A  42
ILE A  78
LEU A  76
ILE A  51
 None
 0.85A 4dtaB-4gh4A:
undetectable		 4dtaB-4gh4A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifd EXOSOME COMPLEX
COMPONENT RRP43

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH) 		4 ILE C 299
ILE C 331
LEU C 334
ILE C 343
 None
 0.95A 4dtaB-4ifdC:
undetectable		 4dtaB-4ifdC:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdu AEROTOLERANCE-RELATE
D MEMBRANE PROTEIN

(Bacteroides
fragilis) 		PF00092
(VWA) 		4 SER A 110
ILE A  98
LEU A  96
ILE A 160
 None
None
None
MLY  A 116 ( 4.2A)
 0.82A 4dtaB-4jduA:
undetectable		 4dtaB-4jduA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jin RIO-TYPE
SERINE/THREONINE-PRO
TEIN KINASE RIO1

(Archaeoglobus
fulgidus) 		PF01163
(RIO1) 		4 SER A  56
PRO A 135
ILE A 150
ILE A 211
 1L7  A 301 (-2.8A)
1L7  A 301 ( 4.7A)
1L7  A 301 (-4.0A)
1L7  A 301 (-4.4A)
 0.82A 4dtaB-4jinA:
6.5		 4dtaB-4jinA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le7 PYOCIN L1

(Pseudomonas
aeruginosa) 		PF01453
(B_lectin) 		4 SER A   3
ILE A 248
PRO A 127
ILE A 125
 None
 0.88A 4dtaB-4le7A:
undetectable		 4dtaB-4le7A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m03 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		4 ILE A 228
ILE A 270
LEU A 245
ILE A 258
 None
 0.93A 4dtaB-4m03A:
undetectable		 4dtaB-4m03A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 SER A 569
ILE A 621
ILE A 640
ILE A 472
ASP A 499
 None
 1.03A 4dtaB-4om9A:
undetectable		 4dtaB-4om9A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 ILE B 432
ILE B 463
LEU B 410
ILE B 396
 None
 0.92A 4dtaB-4qj4B:
undetectable		 4dtaB-4qj4B:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9v N-ALPHA-ACETYLTRANSF
ERASE 40

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		4 LYS B  46
ILE B  57
LEU B 109
ILE B 158
 None
 0.96A 4dtaB-4u9vB:
undetectable		 4dtaB-4u9vB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v03 SITE-DETERMINING
PROTEIN

(Aquifex
aeolicus) 		PF01656
(CbiA) 		4 ILE A 172
ILE A 203
LEU A 246
ILE A 200
 None
 0.91A 4dtaB-4v03A:
undetectable		 4dtaB-4v03A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		4 PRO A 245
ILE A 264
LEU A 288
ILE A 267
 None
 0.94A 4dtaB-4v2dA:
undetectable		 4dtaB-4v2dA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3q YIII_M4_AII

(synthetic
construct) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 ILE A  88
ILE A  80
ILE A  46
ASP A  43
 None
 0.89A 4dtaB-4v3qA:
undetectable		 4dtaB-4v3qA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3q YIII_M4_AII

(synthetic
construct) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 ILE A 130
ILE A 122
ILE A  88
ASP A  85
 None
None
None
CA  A1257 ( 4.9A)
 0.86A 4dtaB-4v3qA:
undetectable		 4dtaB-4v3qA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3q YIII_M4_AII

(synthetic
construct) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 ILE A 172
ILE A 164
ILE A 130
ASP A 127
 None
 0.79A 4dtaB-4v3qA:
undetectable		 4dtaB-4v3qA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh3 N-ACETYLHEXOSAMINE
1-KINASE

(Bifidobacterium
longum) 		PF01636
(APH) 		4 ILE A  46
ILE A 105
LEU A 215
ILE A 227
 ATP  A 401 (-4.1A)
ATP  A 401 (-3.9A)
GOL  A 404 ( 4.7A)
ATP  A 401 (-4.1A)
 0.31A 4dtaB-4wh3A:
16.3		 4dtaB-4wh3A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ytw MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
35
PROTEIN UPS1,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF04707
(PRELI)
PF05254
(UPF0203) 		4 ILE B  40
ILE B  79
LEU B  98
ASP A  67
 None
 0.80A 4dtaB-4ytwB:
undetectable		 4dtaB-4ytwB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 PRO A 199
ILE A 198
LEU A 226
ILE A 202
 None
 0.95A 4dtaB-4z61A:
undetectable		 4dtaB-4z61A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zad FDC1

(Candida
dubliniensis) 		PF01977
(UbiD) 		4 ILE A  70
PRO A  50
ILE A  25
ILE A  38
 None
 0.94A 4dtaB-4zadA:
undetectable		 4dtaB-4zadA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d04 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Neisseria
meningitidis) 		PF00793
(DAHP_synth_1) 		4 SER C 143
ILE C  59
LEU C  78
ILE C  91
 None
 0.94A 4dtaB-5d04C:
undetectable		 4dtaB-5d04C:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzz DESMOPLAKIN

(Homo sapiens) 		PF00681
(Plectin) 		4 ILE A2073
ILE A2058
LEU A2049
ILE A2086
 None
 0.89A 4dtaB-5dzzA:
undetectable		 4dtaB-5dzzA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		4 ILE A 270
ILE A 261
ILE A 277
ASP A 275
 None
 0.86A 4dtaB-5fsaA:
undetectable		 4dtaB-5fsaA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 SER B 124
ILE B  97
LEU B 134
ILE B 136
 None
 0.93A 4dtaB-5gqrB:
undetectable		 4dtaB-5gqrB:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 ILE A 157
ILE A 129
LEU A   7
ILE A 139
 None
 0.89A 4dtaB-5huuA:
undetectable		 4dtaB-5huuA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzl LMO2445 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 PRO B 255
ILE B 240
LEU B 281
ILE B 225
 None
 0.93A 4dtaB-5hzlB:
undetectable		 4dtaB-5hzlB:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilq ASPARTATE
CARBAMOYLTRANSFERASE

(Plasmodium
falciparum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LYS A  58
ILE A 370
LEU A 366
ILE A 178
 None
 0.89A 4dtaB-5ilqA:
undetectable		 4dtaB-5ilqA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqm PROTEIN UPS1,
MITOCHONDRIAL,MITOCH
ONDRIAL DISTRIBUTION
AND MORPHOLOGY
PROTEIN 35

(Saccharomyces
cerevisiae) 		PF04707
(PRELI)
PF05254
(UPF0203) 		4 ILE A  40
ILE A  79
LEU A  98
ASP A 250
 None
 0.76A 4dtaB-5jqmA:
undetectable		 4dtaB-5jqmA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k10 ISOCITRATE
DEHYDROGENASE [NADP]
CYTOPLASMIC

(Homo sapiens) 		PF00180
(Iso_dh) 		4 ILE A 112
ILE A 117
LEU A 376
ILE A 367
 None
 0.79A 4dtaB-5k10A:
undetectable		 4dtaB-5k10A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 ILE A 517
ILE A 526
LEU A 462
ILE A 481
 None
 0.85A 4dtaB-5lewA:
undetectable		 4dtaB-5lewA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgt KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY B MEMBER 1

(Homo sapiens) 		no annotation 4 ILE C 190
ILE C 132
LEU C 138
ILE C 192
 None
 0.88A 4dtaB-5mgtC:
undetectable		 4dtaB-5mgtC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3p MEMBRANE-ASSOCIATED
PROTEIN SLR1513

(Synechocystis
sp. PCC 6803) 		no annotation 4 ILE A  20
ILE A  64
LEU A   8
ILE A  75
 None
 0.94A 4dtaB-5o3pA:
undetectable		 4dtaB-5o3pA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odd MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 26

(Homo sapiens) 		no annotation 4 PRO A   8
ILE A  11
LEU A  38
ILE A  43
 None
 0.86A 4dtaB-5oddA:
undetectable		 4dtaB-5oddA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a)
PF07885
(Ion_trans_2) 		4 SER A 779
ILE A 836
LEU A 888
ILE A 847
 None
 0.94A 4dtaB-5u70A:
undetectable		 4dtaB-5u70A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w11 GLUCANASE

(Thermothelomyces
thermophila) 		no annotation 4 ILE A  34
PRO A  12
ILE A  32
LEU A  91
 None
 0.90A 4dtaB-5w11A:
undetectable		 4dtaB-5w11A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wso NS3 HELICASE

(Pestivirus A) 		no annotation 4 SER A 549
ILE A 544
ILE A 540
ILE A 578
 None
 0.84A 4dtaB-5wsoA:
undetectable		 4dtaB-5wsoA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7f UGGT

(Thermomyces
dupontii) 		PF01501
(Glyco_transf_8) 		4 ILE A1401
PRO A1315
LEU A1370
ILE A1399
 None
 0.94A 4dtaB-5y7fA:
undetectable		 4dtaB-5y7fA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6an5 ABC TRANSPORTER

(Aquifex
aeolicus) 		no annotation 4 ILE A 104
LEU A 122
ILE A 126
ASP A 132
 None
 0.94A 4dtaB-6an5A:
undetectable		 4dtaB-6an5A:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus) 		no annotation 5 ILE A 224
PRO A 258
ILE A 277
LEU A 381
ILE A 392
 GNP  A 500 (-3.7A)
None
GNP  A 500 (-3.8A)
None
GNP  A 500 (-3.9A)
 0.57A 4dtaB-6ceyA:
30.8		 4dtaB-6ceyA:
14.38