SIMILAR PATTERNS OF AMINO ACIDS FOR 4DT8_A_ADNA401_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aj8 | CITRATE SYNTHASE (Pyrococcusfuriosus) |
PF00285(Citrate_synt) | 5 | GLY A 125ILE A 338ILE A 215LEU A 212ILE A 102 | None | 1.07A | 4dt8A-1aj8A:undetectable | 4dt8A-1aj8A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1clx | XYLANASE A (Cellvibriojaponicus) |
PF00331(Glyco_hydro_10) | 5 | GLY A 339ALA A 343ILE A 244LEU A 247ILE A 286 | None | 1.09A | 4dt8A-1clxA:undetectable | 4dt8A-1clxA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i5g | TRYPAREDOXIN II (Crithidiafasciculata) |
PF13905(Thioredoxin_8) | 5 | SER A 44ILE A 110ILE A 69LEU A 68ASP A 72 | NoneTS5 A 401 (-4.1A)NoneNoneNone | 1.09A | 4dt8A-1i5gA:undetectable | 4dt8A-1i5gA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nw1 | CHOLINE KINASE (49.2KD) (Caenorhabditiselegans) |
PF01633(Choline_kinase) | 5 | GLY A 84PRO A 139ILE A 154LEU A 262ILE A 300 | None | 1.05A | 4dt8A-1nw1A:1.8 | 4dt8A-1nw1A:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pmj | BETA-1,4-MANNANASE (Caldicellulosiruptorsaccharolyticus) |
PF09212(CBM27) | 5 | GLY X 127ALA X 126ILE X 122ILE X 173ILE X 91 | EDO X 401 (-3.4A)EDO X 401 ( 4.2A)NoneNoneNone | 1.00A | 4dt8A-1pmjX:undetectable | 4dt8A-1pmjX:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pwe | L-SERINE DEHYDRATASE (Rattusnorvegicus) |
PF00291(PALP) | 5 | ALA A 315PRO A 268ILE A 255LEU A 265ILE A 308 | None | 1.05A | 4dt8A-1pweA:undetectable | 4dt8A-1pweA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s4d | UROPORPHYRIN-IIIC-METHYLTRANSFERASE (Pseudomonasdenitrificans(nomenrejiciendum)) |
PF00590(TP_methylase) | 5 | ALA A 191ILE A 173LEU A 155ILE A 168ASP A 166 | None | 1.04A | 4dt8A-1s4dA:undetectable | 4dt8A-1s4dA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ua4 | ADP-DEPENDENTGLUCOKINASE (Pyrococcusfuriosus) |
PF04587(ADP_PFK_GK) | 5 | GLY A 115ALA A 118ILE A 149HIS A 132LEU A 136 | None | 1.06A | 4dt8A-1ua4A:undetectable | 4dt8A-1ua4A:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v6c | ALKALINE SERINEPROTEASE (Pseudoalteromonassp. AS-11) |
PF00082(Peptidase_S8)PF02225(PA) | 5 | GLY A 305ALA A 303ILE A 292LEU A 322ILE A 329 | None | 1.01A | 4dt8A-1v6cA:undetectable | 4dt8A-1v6cA:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vjq | DESIGNED PROTEIN (-) |
PF02244(Propep_M14) | 5 | ALA A 21PRO A 8ILE A 62LEU A 57ILE A 6 | None | 1.01A | 4dt8A-1vjqA:undetectable | 4dt8A-1vjqA:15.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vr0 | PROBABLE2-PHOSPHOSULFOLACTATE PHOSPHATASE (Clostridiumacetobutylicum) |
PF04029(2-ph_phosp) | 5 | SER A 112ALA A 22ILE A 118ILE A 234ILE A 120 | None | 1.02A | 4dt8A-1vr0A:undetectable | 4dt8A-1vr0A:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ybw | HEPATOCYTE GROWTHFACTOR ACTIVATORPRECURSOR (Homo sapiens) |
PF00089(Trypsin) | 5 | SER A 444GLY A 599ALA A 445PRO A 453ILE A 427 | None | 1.04A | 4dt8A-1ybwA:undetectable | 4dt8A-1ybwA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zao | RIO2 SERINE KINASE (Archaeoglobusfulgidus) |
PF01163(RIO1)PF09202(Rio2_N) | 5 | LYS A 120PRO A 167ILE A 182LEU A 225ILE A 234 | ATP A 286 (-2.6A)ATP A 286 ( 4.7A)ATP A 286 (-4.2A)NoneATP A 286 (-4.5A) | 1.00A | 4dt8A-1zaoA:10.4 | 4dt8A-1zaoA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b3t | PROTEINMETHYLTRANSFERASEHEMK (Escherichiacoli) |
PF13847(Methyltransf_31) | 5 | GLY A 119ALA A 149ILE A 163ILE A 137LEU A 114 | SAH A 300 (-3.5A)NoneNoneNoneNone | 1.11A | 4dt8A-2b3tA:undetectable | 4dt8A-2b3tA:25.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bac | PUTATIVEAMINOOXIDASE (Cutibacteriumacnes) |
PF01593(Amino_oxidase) | 5 | GLY A 18ALA A 17PRO A 372ILE A 402LEU A 256 | NoneFAD A 500 (-3.1A)NoneNoneNone | 1.08A | 4dt8A-2bacA:undetectable | 4dt8A-2bacA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2buc | DIPEPTIDYL PEPTIDASEIV (Sus scrofa) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 6 | SER A 644GLY A 643ALA A 642ILE A 607ILE A 544ILE A 626 | None | 1.18A | 4dt8A-2bucA:undetectable | 4dt8A-2bucA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bwp | 5-AMINOLEVULINATESYNTHASE (Rhodobactercapsulatus) |
PF00155(Aminotran_1_2) | 5 | GLY A 208ALA A 204ILE A 182ILE A 135LEU A 133 | None | 1.04A | 4dt8A-2bwpA:undetectable | 4dt8A-2bwpA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fko | 173AA LONGHYPOTHETICALFERRIPYOCHELINBINDING PROTEIN (Pyrococcushorikoshii) |
PF00132(Hexapep) | 5 | SER A 101GLY A 118ALA A 119ILE A 115ILE A 96 | None | 1.06A | 4dt8A-2fkoA:undetectable | 4dt8A-2fkoA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3m | PROLYL-TRNASYNTHETASE (Enterococcusfaecalis) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF04073(tRNA_edit) | 5 | ILE A 462PRO A 465ILE A 468LEU A 53ILE A 452 | None | 1.02A | 4dt8A-2j3mA:undetectable | 4dt8A-2j3mA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oae | DIPEPTIDYL PEPTIDASE4 (Rattusnorvegicus) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 5 | SER A 645GLY A 644ILE A 608ILE A 545ILE A 627 | None | 1.06A | 4dt8A-2oaeA:undetectable | 4dt8A-2oaeA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2obm | ESCN (Escherichiacoli) |
PF00006(ATP-synt_ab) | 5 | GLY A 193ALA A 194ILE A 343ILE A 161ASP A 162 | None | 0.94A | 4dt8A-2obmA:undetectable | 4dt8A-2obmA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p4g | HYPOTHETICAL PROTEIN (Corynebacteriumdiphtheriae) |
PF01872(RibD_C) | 5 | GLY A 70ALA A 72ILE A 75HIS A 212ILE A 38 | EDO A 279 (-4.9A)NoneNoneNoneEDO A 278 (-4.7A) | 0.94A | 4dt8A-2p4gA:undetectable | 4dt8A-2p4gA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pjs | UNCHARACTERIZEDPROTEIN ATU1953 (Agrobacteriumfabrum) |
PF00903(Glyoxalase) | 5 | GLY A 83ALA A 82ILE A 25ILE A 112LEU A 100 | None | 1.08A | 4dt8A-2pjsA:undetectable | 4dt8A-2pjsA:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ps2 | PUTATIVE MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Aspergillusoryzae) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 279ALA A 273LYS A 272ILE A 257ILE A 266 | None | 1.03A | 4dt8A-2ps2A:undetectable | 4dt8A-2ps2A:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q1d | 2-KETO-3-DEOXY-D-ARABINONATE DEHYDRATASE (Sulfolobussolfataricus) |
PF01557(FAA_hydrolase) | 5 | ALA X 147ILE X 251PRO X 70LEU X 34ILE X 194 | None | 1.10A | 4dt8A-2q1dX:undetectable | 4dt8A-2q1dX:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q83 | YTAA PROTEIN (Bacillussubtilis) |
PF01636(APH) | 5 | LYS A 72PRO A 99ILE A 124LEU A 246ILE A 256 | NoneADN A 1 ( 4.9A)ADN A 1 (-4.6A)NoneADN A 1 ( 4.6A) | 0.84A | 4dt8A-2q83A:14.7 | 4dt8A-2q83A:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qip | PROTEIN OF UNKNOWNFUNCTION VPA0982 (Vibrioparahaemolyticus) |
PF01936(NYN) | 5 | ALA A 10ILE A 102ILE A 100LEU A 121ILE A 125 | None | 1.05A | 4dt8A-2qipA:undetectable | 4dt8A-2qipA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r0l | HEPATOCYTE GROWTHFACTOR ACTIVATOR (Homo sapiens) |
PF00089(Trypsin) | 5 | SER A 54GLY A 196ALA A 55PRO A 60ILE A 35 | None | 1.00A | 4dt8A-2r0lA:undetectable | 4dt8A-2r0lA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r2d | ZN-DEPENDENTHYDROLASES (Agrobacteriumfabrum) |
PF00753(Lactamase_B) | 5 | GLY A 229ALA A 228ILE A 20ILE A 13HIS A 113 | NoneNoneNoneGOL A 280 ( 4.0A) ZN A 278 ( 3.2A) | 1.03A | 4dt8A-2r2dA:undetectable | 4dt8A-2r2dA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdc | GLUTAMATE SYNTHASE[NADPH] LARGE CHAIN (Azospirillumbrasilense) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 5 | GLY A1277ALA A1280ILE A1284ILE A1215ASP A1212 | None | 0.97A | 4dt8A-2vdcA:undetectable | 4dt8A-2vdcA:12.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wwd | 1,4-BETA-N-ACETYLMURAMIDASE (Streptococcuspneumoniae) |
PF01183(Glyco_hydro_25)PF01473(CW_binding_1) | 5 | GLY A 398ALA A 397ILE A 346LEU A 356ILE A 360 | None | 1.05A | 4dt8A-2wwdA:undetectable | 4dt8A-2wwdA:18.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ab1 | FERREDOXIN--NADPREDUCTASE (Chlorobaculumtepidum) |
PF07992(Pyr_redox_2) | 5 | GLY A 171ALA A 175ILE A 168LEU A 137ILE A 257 | None | 1.07A | 4dt8A-3ab1A:undetectable | 4dt8A-3ab1A:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3afg | SUBTILISIN-LIKESERINE PROTEASE (Thermococcuskodakarensis) |
PF00082(Peptidase_S8)PF04151(PPC) | 5 | SER A 515ALA A 445ILE A 442PRO A 468LEU A 465 | None | 1.01A | 4dt8A-3afgA:undetectable | 4dt8A-3afgA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bws | PROTEIN LP49 (Leptospirainterrogans) |
PF10282(Lactonase) | 5 | ILE A 239PRO A 279ILE A 293LEU A 291ILE A 259 | None | 1.04A | 4dt8A-3bwsA:2.4 | 4dt8A-3bwsA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c6a | TERMINASE LARGESUBUNIT (Escherichiavirus RB49) |
PF17289(Terminase_6C) | 5 | GLY A 548ALA A 499ILE A 362LEU A 520ILE A 504 | None | 1.07A | 4dt8A-3c6aA:undetectable | 4dt8A-3c6aA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dci | ARYLESTERASE (Agrobacteriumfabrum) |
PF13472(Lipase_GDSL_2) | 5 | GLY A 168ALA A 164ILE A 130ILE A 84LEU A 82 | None | 0.91A | 4dt8A-3dciA:undetectable | 4dt8A-3dciA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dho | STREPTOGRAMIN AACETYLTRANSFERASE (Enterococcusfaecium) |
PF00132(Hexapep) | 5 | GLY A 157ALA A 156ILE A 150ILE A 116ILE A 122 | B2M A 302 (-3.5A)NoneNoneNoneNone | 1.10A | 4dt8A-3dhoA:undetectable | 4dt8A-3dhoA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5q | PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASE (Staphylococcusaureus) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N)PF07831(PYNP_C) | 5 | GLY A 362ALA A 363ILE A 354LEU A 411ILE A 378 | None | 0.92A | 4dt8A-3h5qA:undetectable | 4dt8A-3h5qA:22.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ham | AMINOGLYCOSIDEPHOSPHOTRANSFERASE (Enterococcusfaecium) |
PF01636(APH) | 5 | LYS A 42PRO A 73ILE A 88ILE A 209ASP A 210 | None | 0.76A | 4dt8A-3hamA:21.4 | 4dt8A-3hamA:34.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwj | PUTATIVEAMINOALDEHYDEDEHYDROGENASE (Pisum sativum) |
PF00171(Aldedh) | 5 | GLY A 372PRO A 397ILE A 345LEU A 346ILE A 375 | None | 1.00A | 4dt8A-3iwjA:undetectable | 4dt8A-3iwjA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j7a | 40S RIBOSOMALPROTEIN ES2140S RIBOSOMALPROTEIN US2 (Plasmodiumfalciparum) |
PF00318(Ribosomal_S2)PF01249(Ribosomal_S21e) | 5 | GLY Z 37ALA C 66PRO C 142LEU Z 68ILE Z 34 | None | 0.80A | 4dt8A-3j7aZ:undetectable | 4dt8A-3j7aZ:13.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3led | 3-OXOACYL-ACYLCARRIER PROTEINSYNTHASE III (Rhodopseudomonaspalustris) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | GLY A 10ALA A 107ILE A 209LEU A 163ILE A 6 | None | 1.06A | 4dt8A-3ledA:undetectable | 4dt8A-3ledA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mqt | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Shewanellapealeana) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 98ALA A 101ILE A 66LEU A 63ILE A 56 | None | 1.07A | 4dt8A-3mqtA:undetectable | 4dt8A-3mqtA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mv3 | COATOMER SUBUNITALPHA (Saccharomycescerevisiae) |
PF06957(COPI_C) | 5 | GLY A 932ILE A1187ILE A1017LEU A1038ASP A1166 | None | 1.02A | 4dt8A-3mv3A:undetectable | 4dt8A-3mv3A:22.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n4t | APH(2'')-ID (Enterococcuscasseliflavus) |
PF01636(APH) | 11 | SER A 28GLY A 29ALA A 36ILE A 44LYS A 46PRO A 76ILE A 98HIS A 202LEU A 204ILE A 216ASP A 217 | None | 0.48A | 4dt8A-3n4tA:43.1 | 4dt8A-3n4tA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oum | TOXOFLAVIN-DEGRADINGENZYME (Paenibacilluspolymyxa) |
PF00903(Glyoxalase) | 5 | SER A 108GLY A 109ILE A 46HIS A 60ILE A 61 | NoneNoneNone MN A 233 ( 3.5A)None | 0.99A | 4dt8A-3oumA:undetectable | 4dt8A-3oumA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oz7 | PHOSPHOGLYCERATEKINASE (Plasmodiumfalciparum) |
PF00162(PGK) | 5 | GLY A 261ILE A 268ILE A 279LEU A 281ILE A 235 | None | 1.04A | 4dt8A-3oz7A:undetectable | 4dt8A-3oz7A:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qk7 | TRANSCRIPTIONALREGULATORS (Yersinia pestis) |
PF00532(Peripla_BP_1) | 5 | GLY A 174ALA A 177PRO A 188ILE A 217ILE A 191 | None | 1.06A | 4dt8A-3qk7A:undetectable | 4dt8A-3qk7A:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qqz | PUTATIVEUNCHARACTERIZEDPROTEIN YJIK (Escherichiacoli) |
PF06977(SdiA-regulated) | 5 | GLY A 219ILE A 178PRO A 181ILE A 180ILE A 228 | None | 1.04A | 4dt8A-3qqzA:undetectable | 4dt8A-3qqzA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ram | HMRA PROTEIN (Staphylococcusaureus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | SER A 102GLY A 99ALA A 101ILE A 327HIS A 156 | NoneNoneNoneNone ZN A 999 ( 3.3A) | 1.07A | 4dt8A-3ramA:2.1 | 4dt8A-3ramA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sl1 | ARGINASE (Plasmodiumfalciparum) |
PF00491(Arginase) | 5 | GLY A 269ILE A 299ILE A 354LEU A 355ILE A 303 | None | 1.01A | 4dt8A-3sl1A:undetectable | 4dt8A-3sl1A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tdw | GENTAMICINRESISTANCE PROTEIN (Enterococcusgallinarum) |
PF01636(APH) | 6 | GLY A 28ALA A 35PRO A 75HIS A 201LEU A 203ILE A 217 | GDP A 500 (-3.4A)GDP A 500 (-3.6A)None MG A 501 ( 3.4A)NoneGDP A 500 ( 4.1A) | 0.52A | 4dt8A-3tdwA:29.6 | 4dt8A-3tdwA:29.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrb | FLAVOPROTEIN SUBUNITOF COMPLEX II (Ascaris suum) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | SER A 291GLY A 290ILE A 363ILE A 280HIS A 387 | NoneNoneNoneNoneFUM A 701 ( 3.6A) | 1.01A | 4dt8A-3vrbA:undetectable | 4dt8A-3vrbA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wb1 | UNCHARACTERIZEDPROTEIN MJ0488 (Methanocaldococcusjannaschii) |
PF11576(DUF3236) | 5 | ALA A 64ILE A 66ILE A 54LEU A 147ILE A 100 | None | 0.95A | 4dt8A-3wb1A:undetectable | 4dt8A-3wb1A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zw6 | RIBULOSEBISPHOSPHATECARBOXYLASE/OXYGENASE ACTIVASE 1,CHLOROPLASTIC (Nicotianatabacum) |
PF00004(AAA) | 5 | GLY A 128PRO A 224ILE A 226LEU A 86ILE A 90 | None | 1.10A | 4dt8A-3zw6A:undetectable | 4dt8A-3zw6A:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b8j | IMPORTIN SUBUNITALPHA-1A (Oryza sativa) |
PF00514(Arm)PF01749(IBB)PF16186(Arm_3) | 5 | SER A 114GLY A 115ILE A 108LEU A 100ILE A 143 | None | 1.04A | 4dt8A-4b8jA:undetectable | 4dt8A-4b8jA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bpl | IMPORTIN SUBUNITALPHA-1A (Oryza sativa) |
PF00514(Arm)PF16186(Arm_3) | 5 | SER A 114GLY A 115ILE A 108LEU A 100ILE A 143 | None | 1.10A | 4dt8A-4bplA:undetectable | 4dt8A-4bplA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c5f | MEMBRANE-BOUND LYTICMUREINTRANSGLYCOSYLASE C (Escherichiacoli) |
PF01464(SLT)PF11873(DUF3393) | 5 | SER A 152GLY A 149ALA A 151ILE A 104ILE A 127 | None | 1.02A | 4dt8A-4c5fA:undetectable | 4dt8A-4c5fA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cn8 | PROXIMAL THREADMATRIX PROTEIN 1 (Mytilusgalloprovincialis) |
PF00092(VWA) | 5 | GLY A 204PRO A 182ILE A 213LEU A 170ILE A 141 | None | 0.94A | 4dt8A-4cn8A:undetectable | 4dt8A-4cn8A:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fda | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Saccharomycescerevisiae) |
PF00106(adh_short) | 5 | GLY A 11ALA A 12ILE A 33LEU A 98ILE A 8 | NAP A 301 (-3.0A)NoneNoneNoneNone | 0.84A | 4dt8A-4fdaA:undetectable | 4dt8A-4fdaA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ffy | DENV1-E111 SINGLECHAIN VARIABLEFRAGMENT (LIGHTCHAIN) (Mus musculus) |
PF07686(V-set) | 5 | GLY L 66ALA L 51ILE L 33ILE L 2ASP L 30 | None | 0.89A | 4dt8A-4ffyL:undetectable | 4dt8A-4ffyL:17.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gji | L-RHAMNOSE ISOMERASE (Pseudomonasstutzeri) |
no annotation | 5 | SER A 409GLY A 410ILE A 88ILE A 336ASP A 334 | None | 0.93A | 4dt8A-4gjiA:undetectable | 4dt8A-4gjiA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gm2 | ATP-DEPENDENT CLPPROTEASE PROTEOLYTICSUBUNIT (Plasmodiumfalciparum) |
PF00574(CLP_protease) | 5 | SER A 106GLY A 108ALA A 150ILE A 70ILE A 84 | None | 1.10A | 4dt8A-4gm2A:undetectable | 4dt8A-4gm2A:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h27 | L-SERINEDEHYDRATASE/L-THREONINE DEAMINASE (Homo sapiens) |
PF00291(PALP) | 5 | ALA A 315PRO A 268ILE A 255LEU A 265ILE A 308 | None | 1.07A | 4dt8A-4h27A:undetectable | 4dt8A-4h27A:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h3w | HYPOTHETICAL PROTEIN (Parabacteroidesdistasonis) |
PF15414(DUF4621) | 5 | GLY A 76ILE A 99ILE A 138LEU A 136ILE A 121 | None | 0.95A | 4dt8A-4h3wA:undetectable | 4dt8A-4h3wA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h7o | SERINEACETYLTRANSFERASE (Vibrio cholerae) |
PF00132(Hexapep)PF06426(SATase_N) | 5 | GLY A 165ALA A 168ILE A 154LEU A 156ILE A 176 | CYS A 301 ( 4.6A)NoneNoneNoneNone | 1.10A | 4dt8A-4h7oA:undetectable | 4dt8A-4h7oA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ifd | EXOSOME COMPLEXCOMPONENT RRP43 (Saccharomycescerevisiae) |
PF01138(RNase_PH) | 5 | GLY C 364ILE C 299ILE C 331LEU C 334ILE C 343 | None | 1.01A | 4dt8A-4ifdC:undetectable | 4dt8A-4ifdC:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kwg | ALDEHYDEDEHYDROGENASE,MITOCHONDRIAL (Homo sapiens) |
PF00171(Aldedh) | 5 | GLY A 378PRO A 403ILE A 353LEU A 354ILE A 381 | None | 1.03A | 4dt8A-4kwgA:undetectable | 4dt8A-4kwgA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lqz | UNCHARACTERIZEDPROTEIN (Staphylococcusaureus) |
PF16253(DUF4909) | 5 | ALA A 65ILE A 83ILE A 38LEU A 154ILE A 48 | None | 1.05A | 4dt8A-4lqzA:undetectable | 4dt8A-4lqzA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lrj | EFFECTOR NLEH1 (Escherichiacoli) |
no annotation | 5 | GLY A 140LYS A 159ILE A 204LEU A 246ILE A 257 | ANP A 301 ( 3.9A)ANP A 301 (-3.6A)ANP A 301 (-4.3A)NoneANP A 301 (-4.2A) | 0.86A | 4dt8A-4lrjA:7.6 | 4dt8A-4lrjA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mna | LRR RECEPTOR-LIKESERINE/THREONINE-PROTEIN KINASE FLS2 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13516(LRR_6)PF13855(LRR_8) | 5 | GLY A 318PRO A 353ILE A 356LEU A 359ILE A 332 | None | 1.10A | 4dt8A-4mnaA:undetectable | 4dt8A-4mnaA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4na3 | POLYKETIDE SYNTHASEPKSJ (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | GLY A 201ALA A 200ILE A 183LEU A 374ILE A 9 | None | 1.10A | 4dt8A-4na3A:undetectable | 4dt8A-4na3A:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pii | N-GLYCOSYLASE/DNALYASE (Pyrococcusfuriosus) |
PF09171(AGOG) | 5 | SER A 157GLY A 154ALA A 156ILE A 43ILE A 47 | None | 0.99A | 4dt8A-4piiA:undetectable | 4dt8A-4piiA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tr6 | DNA POLYMERASE IIISUBUNIT BETA (Bacillussubtilis) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 5 | ALA A 320ILE A 266ILE A 362LEU A 341ILE A 349 | None | 1.07A | 4dt8A-4tr6A:undetectable | 4dt8A-4tr6A:24.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u1a | ENOYL-COA DELTAISOMERASE 2 (Homo sapiens) |
PF00378(ECH_1) | 5 | SER A 162GLY A 164ILE A 118LEU A 107ILE A 137 | None | 1.09A | 4dt8A-4u1aA:undetectable | 4dt8A-4u1aA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w7v | CELLULASE (Xanthomonascitri) |
PF00150(Cellulase) | 5 | GLY A 108ALA A 107ILE A 100PRO A 135LEU A 89 | None | 1.03A | 4dt8A-4w7vA:undetectable | 4dt8A-4w7vA:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wh3 | N-ACETYLHEXOSAMINE1-KINASE (Bifidobacteriumlongum) |
PF01636(APH) | 5 | GLY A 28ILE A 46ILE A 105LEU A 215ILE A 227 | ATP A 401 (-3.3A)ATP A 401 (-4.1A)ATP A 401 (-3.9A)GOL A 404 ( 4.7A)ATP A 401 (-4.1A) | 0.93A | 4dt8A-4wh3A:16.4 | 4dt8A-4wh3A:23.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zoq | INTRACELLULAR SERINEPROTEASE (Bacilluslicheniformis) |
PF00082(Peptidase_S8) | 5 | GLY I 274ALA I 273ILE I 321ILE I 425ILE I 311 | None | 1.02A | 4dt8A-4zoqI:undetectable | 4dt8A-4zoqI:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5abm | RETINALDEHYDROGENASE 1 (Ovis aries) |
PF00171(Aldedh) | 5 | GLY A 378PRO A 403ILE A 353LEU A 354ILE A 381 | None | 0.99A | 4dt8A-5abmA:undetectable | 4dt8A-5abmA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b69 | GERANYLGERANYLGLYCERYL PHOSPHATESYNTHASE (Thermoplasmaacidophilum) |
PF01884(PcrB) | 5 | GLY A 224ALA A 227ILE A 35ILE A 67ILE A 47 | 1GP A 501 (-3.4A)NoneNoneNoneNone | 0.78A | 4dt8A-5b69A:undetectable | 4dt8A-5b69A:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dkv | ABC TRANSPORTERSUBSTRATE BINDINGPROTEIN (RIBOSE) (Agrobacteriumvitis) |
PF13407(Peripla_BP_4) | 5 | GLY A 288ALA A 292ILE A 35PRO A 90ILE A 66 | None | 1.07A | 4dt8A-5dkvA:undetectable | 4dt8A-5dkvA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dnl | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE (Pyrococcusfuriosus) |
PF00475(IGPD) | 5 | GLY A 63ALA A 65ILE A 14LEU A 31ILE A 44 | None | 0.98A | 4dt8A-5dnlA:undetectable | 4dt8A-5dnlA:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7s | LON PROTEASE (Meiothermustaiwanensis) |
PF05362(Lon_C) | 5 | ALA A 502ILE A 527ILE A 574LEU A 578ILE A 550 | None | 1.08A | 4dt8A-5e7sA:undetectable | 4dt8A-5e7sA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5evj | ARSENITEMETHYLTRANSFERASE (Chlamydomonasreinhardtii) |
PF13847(Methyltransf_31) | 5 | GLY A 113ALA A 92PRO A 77ILE A 78ILE A 167 | None | 0.96A | 4dt8A-5evjA:undetectable | 4dt8A-5evjA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fhz | ALDEHYDEDEHYDROGENASE FAMILY1 MEMBER A3 (Homo sapiens) |
PF00171(Aldedh) | 5 | GLY A 390PRO A 415ILE A 365LEU A 366ILE A 393 | None | 1.08A | 4dt8A-5fhzA:undetectable | 4dt8A-5fhzA:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h1y | PROBABLEATP-DEPENDENT RNAHELICASE DDX41 (Homo sapiens) |
PF00270(DEAD) | 5 | GLY A 223ALA A 225ILE A 207ILE A 209ILE A 169 | None | 1.01A | 4dt8A-5h1yA:undetectable | 4dt8A-5h1yA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5it0 | PHOSPHOSERINEPHOSPHATASE (Mycobacteriumavium) |
PF12710(HAD)PF13740(ACT_6) | 5 | SER A 275GLY A 276ALA A 296LEU A 251ILE A 281 | None | 1.10A | 4dt8A-5it0A:undetectable | 4dt8A-5it0A:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uja | BOVINE MULTIDRUGRESISTANCE PROTEIN 1(MRP1),MULTIDRUGRESISTANCE-ASSOCIATED PROTEIN 1 (Bos taurus) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 5 | SER A1236ILE A1107ILE A1118LEU A1121ILE A1117 | None | 1.00A | 4dt8A-5ujaA:undetectable | 4dt8A-5ujaA:10.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uzh | NAFOA.00085.B (Naegleriafowleri) |
PF16363(GDP_Man_Dehyd) | 5 | GLY A 40PRO A 111ILE A 106LEU A 144ILE A 114 | NAP A 402 (-3.2A)NoneNoneNoneNone | 1.07A | 4dt8A-5uzhA:undetectable | 4dt8A-5uzhA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vip | MDCE (Pseudomonasaeruginosa) |
PF06833(MdcE) | 5 | GLY A 232ALA A 234ILE A 133ILE A 94LEU A 16 | None | 1.00A | 4dt8A-5vipA:undetectable | 4dt8A-5vipA:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w11 | GLUCANASE (Thermothelomycesthermophila) |
no annotation | 5 | GLY A 106ILE A 34PRO A 12ILE A 32LEU A 91 | None | 1.09A | 4dt8A-5w11A:undetectable | 4dt8A-5w11A:12.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xsy | SODIUM CHANNELPROTEIN (Electrophoruselectricus) |
PF00520(Ion_trans)PF06512(Na_trans_assoc) | 5 | ALA A 668ILE A 678ILE A 680LEU A1258ILE A 676 | None | 1.07A | 4dt8A-5xsyA:undetectable | 4dt8A-5xsyA:10.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xzx | IMPORTIN SUBUNITALPHA-3 (Homo sapiens) |
PF00514(Arm)PF16186(Arm_3) | 5 | SER A 113GLY A 114ILE A 107LEU A 99ILE A 142 | None | 0.98A | 4dt8A-5xzxA:undetectable | 4dt8A-5xzxA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zbi | PEPTIDE ASPARAGINYLLIGASE (Violacanadensis) |
no annotation | 5 | SER A 459GLY A 456ALA A 458LEU A 442ILE A 445 | None | 1.03A | 4dt8A-5zbiA:undetectable | 4dt8A-5zbiA:11.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6amz | 2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATEN-SUCCINYLTRANSFERASE (Acinetobacterbaumannii) |
PF00132(Hexapep)PF14602(Hexapep_2)PF14805(THDPS_N_2) | 5 | SER A 200GLY A 230ILE A 208HIS A 223ILE A 214 | None | 0.98A | 4dt8A-6amzA:undetectable | 4dt8A-6amzA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b5i | RETINALDEHYDROGENASE 2 (Homo sapiens) |
no annotation | 5 | GLY A 396PRO A 421ILE A 371LEU A 372ILE A 399 | None | 1.01A | 4dt8A-6b5iA:undetectable | 4dt8A-6b5iA:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6beg | SCAFFOLD PROTEIN D13 (Vaccinia virus) |
no annotation | 5 | GLY A 141LYS A 149ILE A 192LEU A 421ILE A 138 | None | 1.01A | 4dt8A-6begA:undetectable | 4dt8A-6begA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cey | BIFUNCTIONAL AAC/APH (Staphylococcusaureus) |
no annotation | 5 | ALA A 216LYS A 226PRO A 258HIS A 379ASP A 393 | GNP A 500 ( 3.9A)GNP A 500 (-2.7A)None MG A 700 ( 3.2A) MG A 702 (-1.7A) | 1.04A | 4dt8A-6ceyA:30.7 | 4dt8A-6ceyA:14.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cey | BIFUNCTIONAL AAC/APH (Staphylococcusaureus) |
no annotation | 8 | GLY A 209ALA A 216ILE A 224LYS A 226PRO A 258ILE A 277HIS A 379ILE A 392 | GNP A 500 ( 4.3A)GNP A 500 ( 3.9A)GNP A 500 (-3.7A)GNP A 500 (-2.7A)NoneGNP A 500 (-3.8A) MG A 700 ( 3.2A)GNP A 500 (-3.9A) | 0.63A | 4dt8A-6ceyA:30.7 | 4dt8A-6ceyA:14.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cey | BIFUNCTIONAL AAC/APH (Staphylococcusaureus) |
no annotation | 8 | GLY A 209ALA A 216ILE A 224PRO A 258ILE A 277HIS A 379LEU A 381ILE A 392 | GNP A 500 ( 4.3A)GNP A 500 ( 3.9A)GNP A 500 (-3.7A)NoneGNP A 500 (-3.8A) MG A 700 ( 3.2A)NoneGNP A 500 (-3.9A) | 0.69A | 4dt8A-6ceyA:30.7 | 4dt8A-6ceyA:14.38 |