SIMILAR PATTERNS OF AMINO ACIDS FOR 4DT8_A_ADNA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus)
PF00285
(Citrate_synt)
5 GLY A 125
ILE A 338
ILE A 215
LEU A 212
ILE A 102
None
1.07A 4dt8A-1aj8A:
undetectable
4dt8A-1aj8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clx XYLANASE A

(Cellvibrio
japonicus)
PF00331
(Glyco_hydro_10)
5 GLY A 339
ALA A 343
ILE A 244
LEU A 247
ILE A 286
None
1.09A 4dt8A-1clxA:
undetectable
4dt8A-1clxA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5g TRYPAREDOXIN II

(Crithidia
fasciculata)
PF13905
(Thioredoxin_8)
5 SER A  44
ILE A 110
ILE A  69
LEU A  68
ASP A  72
None
TS5  A 401 (-4.1A)
None
None
None
1.09A 4dt8A-1i5gA:
undetectable
4dt8A-1i5gA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw1 CHOLINE KINASE (49.2
KD)


(Caenorhabditis
elegans)
PF01633
(Choline_kinase)
5 GLY A  84
PRO A 139
ILE A 154
LEU A 262
ILE A 300
None
1.05A 4dt8A-1nw1A:
1.8
4dt8A-1nw1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmj BETA-1,4-MANNANASE

(Caldicellulosiruptor
saccharolyticus)
PF09212
(CBM27)
5 GLY X 127
ALA X 126
ILE X 122
ILE X 173
ILE X  91
EDO  X 401 (-3.4A)
EDO  X 401 ( 4.2A)
None
None
None
1.00A 4dt8A-1pmjX:
undetectable
4dt8A-1pmjX:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pwe L-SERINE DEHYDRATASE

(Rattus
norvegicus)
PF00291
(PALP)
5 ALA A 315
PRO A 268
ILE A 255
LEU A 265
ILE A 308
None
1.05A 4dt8A-1pweA:
undetectable
4dt8A-1pweA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE


(Pseudomonas
denitrificans
(nomen
rejiciendum))
PF00590
(TP_methylase)
5 ALA A 191
ILE A 173
LEU A 155
ILE A 168
ASP A 166
None
1.04A 4dt8A-1s4dA:
undetectable
4dt8A-1s4dA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE


(Pyrococcus
furiosus)
PF04587
(ADP_PFK_GK)
5 GLY A 115
ALA A 118
ILE A 149
HIS A 132
LEU A 136
None
1.06A 4dt8A-1ua4A:
undetectable
4dt8A-1ua4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6c ALKALINE SERINE
PROTEASE


(Pseudoalteromonas
sp. AS-11)
PF00082
(Peptidase_S8)
PF02225
(PA)
5 GLY A 305
ALA A 303
ILE A 292
LEU A 322
ILE A 329
None
1.01A 4dt8A-1v6cA:
undetectable
4dt8A-1v6cA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjq DESIGNED PROTEIN

(-)
PF02244
(Propep_M14)
5 ALA A  21
PRO A   8
ILE A  62
LEU A  57
ILE A   6
None
1.01A 4dt8A-1vjqA:
undetectable
4dt8A-1vjqA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE


(Clostridium
acetobutylicum)
PF04029
(2-ph_phosp)
5 SER A 112
ALA A  22
ILE A 118
ILE A 234
ILE A 120
None
1.02A 4dt8A-1vr0A:
undetectable
4dt8A-1vr0A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR


(Homo sapiens)
PF00089
(Trypsin)
5 SER A 444
GLY A 599
ALA A 445
PRO A 453
ILE A 427
None
1.04A 4dt8A-1ybwA:
undetectable
4dt8A-1ybwA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zao RIO2 SERINE KINASE

(Archaeoglobus
fulgidus)
PF01163
(RIO1)
PF09202
(Rio2_N)
5 LYS A 120
PRO A 167
ILE A 182
LEU A 225
ILE A 234
ATP  A 286 (-2.6A)
ATP  A 286 ( 4.7A)
ATP  A 286 (-4.2A)
None
ATP  A 286 (-4.5A)
1.00A 4dt8A-1zaoA:
10.4
4dt8A-1zaoA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3t PROTEIN
METHYLTRANSFERASE
HEMK


(Escherichia
coli)
PF13847
(Methyltransf_31)
5 GLY A 119
ALA A 149
ILE A 163
ILE A 137
LEU A 114
SAH  A 300 (-3.5A)
None
None
None
None
1.11A 4dt8A-2b3tA:
undetectable
4dt8A-2b3tA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bac PUTATIVE
AMINOOXIDASE


(Cutibacterium
acnes)
PF01593
(Amino_oxidase)
5 GLY A  18
ALA A  17
PRO A 372
ILE A 402
LEU A 256
None
FAD  A 500 (-3.1A)
None
None
None
1.08A 4dt8A-2bacA:
undetectable
4dt8A-2bacA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV


(Sus scrofa)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
6 SER A 644
GLY A 643
ALA A 642
ILE A 607
ILE A 544
ILE A 626
None
1.18A 4dt8A-2bucA:
undetectable
4dt8A-2bucA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwp 5-AMINOLEVULINATE
SYNTHASE


(Rhodobacter
capsulatus)
PF00155
(Aminotran_1_2)
5 GLY A 208
ALA A 204
ILE A 182
ILE A 135
LEU A 133
None
1.04A 4dt8A-2bwpA:
undetectable
4dt8A-2bwpA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN


(Pyrococcus
horikoshii)
PF00132
(Hexapep)
5 SER A 101
GLY A 118
ALA A 119
ILE A 115
ILE A  96
None
1.06A 4dt8A-2fkoA:
undetectable
4dt8A-2fkoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3m PROLYL-TRNA
SYNTHETASE


(Enterococcus
faecalis)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit)
5 ILE A 462
PRO A 465
ILE A 468
LEU A  53
ILE A 452
None
1.02A 4dt8A-2j3mA:
undetectable
4dt8A-2j3mA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4


(Rattus
norvegicus)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
5 SER A 645
GLY A 644
ILE A 608
ILE A 545
ILE A 627
None
1.06A 4dt8A-2oaeA:
undetectable
4dt8A-2oaeA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli)
PF00006
(ATP-synt_ab)
5 GLY A 193
ALA A 194
ILE A 343
ILE A 161
ASP A 162
None
0.94A 4dt8A-2obmA:
undetectable
4dt8A-2obmA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4g HYPOTHETICAL PROTEIN

(Corynebacterium
diphtheriae)
PF01872
(RibD_C)
5 GLY A  70
ALA A  72
ILE A  75
HIS A 212
ILE A  38
EDO  A 279 (-4.9A)
None
None
None
EDO  A 278 (-4.7A)
0.94A 4dt8A-2p4gA:
undetectable
4dt8A-2p4gA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjs UNCHARACTERIZED
PROTEIN ATU1953


(Agrobacterium
fabrum)
PF00903
(Glyoxalase)
5 GLY A  83
ALA A  82
ILE A  25
ILE A 112
LEU A 100
None
1.08A 4dt8A-2pjsA:
undetectable
4dt8A-2pjsA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Aspergillus
oryzae)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A 279
ALA A 273
LYS A 272
ILE A 257
ILE A 266
None
1.03A 4dt8A-2ps2A:
undetectable
4dt8A-2ps2A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1d 2-KETO-3-DEOXY-D-ARA
BINONATE DEHYDRATASE


(Sulfolobus
solfataricus)
PF01557
(FAA_hydrolase)
5 ALA X 147
ILE X 251
PRO X  70
LEU X  34
ILE X 194
None
1.10A 4dt8A-2q1dX:
undetectable
4dt8A-2q1dX:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q83 YTAA PROTEIN

(Bacillus
subtilis)
PF01636
(APH)
5 LYS A  72
PRO A  99
ILE A 124
LEU A 246
ILE A 256
None
ADN  A   1 ( 4.9A)
ADN  A   1 (-4.6A)
None
ADN  A   1 ( 4.6A)
0.84A 4dt8A-2q83A:
14.7
4dt8A-2q83A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qip PROTEIN OF UNKNOWN
FUNCTION VPA0982


(Vibrio
parahaemolyticus)
PF01936
(NYN)
5 ALA A  10
ILE A 102
ILE A 100
LEU A 121
ILE A 125
None
1.05A 4dt8A-2qipA:
undetectable
4dt8A-2qipA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR


(Homo sapiens)
PF00089
(Trypsin)
5 SER A  54
GLY A 196
ALA A  55
PRO A  60
ILE A  35
None
1.00A 4dt8A-2r0lA:
undetectable
4dt8A-2r0lA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2d ZN-DEPENDENT
HYDROLASES


(Agrobacterium
fabrum)
PF00753
(Lactamase_B)
5 GLY A 229
ALA A 228
ILE A  20
ILE A  13
HIS A 113
None
None
None
GOL  A 280 ( 4.0A)
ZN  A 278 ( 3.2A)
1.03A 4dt8A-2r2dA:
undetectable
4dt8A-2r2dA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN


(Azospirillum
brasilense)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
5 GLY A1277
ALA A1280
ILE A1284
ILE A1215
ASP A1212
None
0.97A 4dt8A-2vdcA:
undetectable
4dt8A-2vdcA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE


(Streptococcus
pneumoniae)
PF01183
(Glyco_hydro_25)
PF01473
(CW_binding_1)
5 GLY A 398
ALA A 397
ILE A 346
LEU A 356
ILE A 360
None
1.05A 4dt8A-2wwdA:
undetectable
4dt8A-2wwdA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab1 FERREDOXIN--NADP
REDUCTASE


(Chlorobaculum
tepidum)
PF07992
(Pyr_redox_2)
5 GLY A 171
ALA A 175
ILE A 168
LEU A 137
ILE A 257
None
1.07A 4dt8A-3ab1A:
undetectable
4dt8A-3ab1A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE


(Thermococcus
kodakarensis)
PF00082
(Peptidase_S8)
PF04151
(PPC)
5 SER A 515
ALA A 445
ILE A 442
PRO A 468
LEU A 465
None
1.01A 4dt8A-3afgA:
undetectable
4dt8A-3afgA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bws PROTEIN LP49

(Leptospira
interrogans)
PF10282
(Lactonase)
5 ILE A 239
PRO A 279
ILE A 293
LEU A 291
ILE A 259
None
1.04A 4dt8A-3bwsA:
2.4
4dt8A-3bwsA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6a TERMINASE LARGE
SUBUNIT


(Escherichia
virus RB49)
PF17289
(Terminase_6C)
5 GLY A 548
ALA A 499
ILE A 362
LEU A 520
ILE A 504
None
1.07A 4dt8A-3c6aA:
undetectable
4dt8A-3c6aA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dci ARYLESTERASE

(Agrobacterium
fabrum)
PF13472
(Lipase_GDSL_2)
5 GLY A 168
ALA A 164
ILE A 130
ILE A  84
LEU A  82
None
0.91A 4dt8A-3dciA:
undetectable
4dt8A-3dciA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dho STREPTOGRAMIN A
ACETYLTRANSFERASE


(Enterococcus
faecium)
PF00132
(Hexapep)
5 GLY A 157
ALA A 156
ILE A 150
ILE A 116
ILE A 122
B2M  A 302 (-3.5A)
None
None
None
None
1.10A 4dt8A-3dhoA:
undetectable
4dt8A-3dhoA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5q PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE


(Staphylococcus
aureus)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C)
5 GLY A 362
ALA A 363
ILE A 354
LEU A 411
ILE A 378
None
0.92A 4dt8A-3h5qA:
undetectable
4dt8A-3h5qA:
22.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE


(Enterococcus
faecium)
PF01636
(APH)
5 LYS A  42
PRO A  73
ILE A  88
ILE A 209
ASP A 210
None
0.76A 4dt8A-3hamA:
21.4
4dt8A-3hamA:
34.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE


(Pisum sativum)
PF00171
(Aldedh)
5 GLY A 372
PRO A 397
ILE A 345
LEU A 346
ILE A 375
None
1.00A 4dt8A-3iwjA:
undetectable
4dt8A-3iwjA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES21
40S RIBOSOMAL
PROTEIN US2


(Plasmodium
falciparum)
PF00318
(Ribosomal_S2)
PF01249
(Ribosomal_S21e)
5 GLY Z  37
ALA C  66
PRO C 142
LEU Z  68
ILE Z  34
None
0.80A 4dt8A-3j7aZ:
undetectable
4dt8A-3j7aZ:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III


(Rhodopseudomonas
palustris)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 GLY A  10
ALA A 107
ILE A 209
LEU A 163
ILE A   6
None
1.06A 4dt8A-3ledA:
undetectable
4dt8A-3ledA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqt MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Shewanella
pealeana)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A  98
ALA A 101
ILE A  66
LEU A  63
ILE A  56
None
1.07A 4dt8A-3mqtA:
undetectable
4dt8A-3mqtA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mv3 COATOMER SUBUNIT
ALPHA


(Saccharomyces
cerevisiae)
PF06957
(COPI_C)
5 GLY A 932
ILE A1187
ILE A1017
LEU A1038
ASP A1166
None
1.02A 4dt8A-3mv3A:
undetectable
4dt8A-3mv3A:
22.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n4t APH(2'')-ID

(Enterococcus
casseliflavus)
PF01636
(APH)
11 SER A  28
GLY A  29
ALA A  36
ILE A  44
LYS A  46
PRO A  76
ILE A  98
HIS A 202
LEU A 204
ILE A 216
ASP A 217
None
0.48A 4dt8A-3n4tA:
43.1
4dt8A-3n4tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oum TOXOFLAVIN-DEGRADING
ENZYME


(Paenibacillus
polymyxa)
PF00903
(Glyoxalase)
5 SER A 108
GLY A 109
ILE A  46
HIS A  60
ILE A  61
None
None
None
MN  A 233 ( 3.5A)
None
0.99A 4dt8A-3oumA:
undetectable
4dt8A-3oumA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz7 PHOSPHOGLYCERATE
KINASE


(Plasmodium
falciparum)
PF00162
(PGK)
5 GLY A 261
ILE A 268
ILE A 279
LEU A 281
ILE A 235
None
1.04A 4dt8A-3oz7A:
undetectable
4dt8A-3oz7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk7 TRANSCRIPTIONAL
REGULATORS


(Yersinia pestis)
PF00532
(Peripla_BP_1)
5 GLY A 174
ALA A 177
PRO A 188
ILE A 217
ILE A 191
None
1.06A 4dt8A-3qk7A:
undetectable
4dt8A-3qk7A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqz PUTATIVE
UNCHARACTERIZED
PROTEIN YJIK


(Escherichia
coli)
PF06977
(SdiA-regulated)
5 GLY A 219
ILE A 178
PRO A 181
ILE A 180
ILE A 228
None
1.04A 4dt8A-3qqzA:
undetectable
4dt8A-3qqzA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ram HMRA PROTEIN

(Staphylococcus
aureus)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 SER A 102
GLY A  99
ALA A 101
ILE A 327
HIS A 156
None
None
None
None
ZN  A 999 ( 3.3A)
1.07A 4dt8A-3ramA:
2.1
4dt8A-3ramA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl1 ARGINASE

(Plasmodium
falciparum)
PF00491
(Arginase)
5 GLY A 269
ILE A 299
ILE A 354
LEU A 355
ILE A 303
None
1.01A 4dt8A-3sl1A:
undetectable
4dt8A-3sl1A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdw GENTAMICIN
RESISTANCE PROTEIN


(Enterococcus
gallinarum)
PF01636
(APH)
6 GLY A  28
ALA A  35
PRO A  75
HIS A 201
LEU A 203
ILE A 217
GDP  A 500 (-3.4A)
GDP  A 500 (-3.6A)
None
MG  A 501 ( 3.4A)
None
GDP  A 500 ( 4.1A)
0.52A 4dt8A-3tdwA:
29.6
4dt8A-3tdwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II


(Ascaris suum)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
5 SER A 291
GLY A 290
ILE A 363
ILE A 280
HIS A 387
None
None
None
None
FUM  A 701 ( 3.6A)
1.01A 4dt8A-3vrbA:
undetectable
4dt8A-3vrbA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wb1 UNCHARACTERIZED
PROTEIN MJ0488


(Methanocaldococcus
jannaschii)
PF11576
(DUF3236)
5 ALA A  64
ILE A  66
ILE A  54
LEU A 147
ILE A 100
None
0.95A 4dt8A-3wb1A:
undetectable
4dt8A-3wb1A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zw6 RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE 1,
CHLOROPLASTIC


(Nicotiana
tabacum)
PF00004
(AAA)
5 GLY A 128
PRO A 224
ILE A 226
LEU A  86
ILE A  90
None
1.10A 4dt8A-3zw6A:
undetectable
4dt8A-3zw6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8j IMPORTIN SUBUNIT
ALPHA-1A


(Oryza sativa)
PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3)
5 SER A 114
GLY A 115
ILE A 108
LEU A 100
ILE A 143
None
1.04A 4dt8A-4b8jA:
undetectable
4dt8A-4b8jA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpl IMPORTIN SUBUNIT
ALPHA-1A


(Oryza sativa)
PF00514
(Arm)
PF16186
(Arm_3)
5 SER A 114
GLY A 115
ILE A 108
LEU A 100
ILE A 143
None
1.10A 4dt8A-4bplA:
undetectable
4dt8A-4bplA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C


(Escherichia
coli)
PF01464
(SLT)
PF11873
(DUF3393)
5 SER A 152
GLY A 149
ALA A 151
ILE A 104
ILE A 127
None
1.02A 4dt8A-4c5fA:
undetectable
4dt8A-4c5fA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cn8 PROXIMAL THREAD
MATRIX PROTEIN 1


(Mytilus
galloprovincialis)
PF00092
(VWA)
5 GLY A 204
PRO A 182
ILE A 213
LEU A 170
ILE A 141
None
0.94A 4dt8A-4cn8A:
undetectable
4dt8A-4cn8A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fda 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Saccharomyces
cerevisiae)
PF00106
(adh_short)
5 GLY A  11
ALA A  12
ILE A  33
LEU A  98
ILE A   8
NAP  A 301 (-3.0A)
None
None
None
None
0.84A 4dt8A-4fdaA:
undetectable
4dt8A-4fdaA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffy DENV1-E111 SINGLE
CHAIN VARIABLE
FRAGMENT (LIGHT
CHAIN)


(Mus musculus)
PF07686
(V-set)
5 GLY L  66
ALA L  51
ILE L  33
ILE L   2
ASP L  30
None
0.89A 4dt8A-4ffyL:
undetectable
4dt8A-4ffyL:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gji L-RHAMNOSE ISOMERASE

(Pseudomonas
stutzeri)
no annotation 5 SER A 409
GLY A 410
ILE A  88
ILE A 336
ASP A 334
None
0.93A 4dt8A-4gjiA:
undetectable
4dt8A-4gjiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm2 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT


(Plasmodium
falciparum)
PF00574
(CLP_protease)
5 SER A 106
GLY A 108
ALA A 150
ILE A  70
ILE A  84
None
1.10A 4dt8A-4gm2A:
undetectable
4dt8A-4gm2A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE


(Homo sapiens)
PF00291
(PALP)
5 ALA A 315
PRO A 268
ILE A 255
LEU A 265
ILE A 308
None
1.07A 4dt8A-4h27A:
undetectable
4dt8A-4h27A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3w HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis)
PF15414
(DUF4621)
5 GLY A  76
ILE A  99
ILE A 138
LEU A 136
ILE A 121
None
0.95A 4dt8A-4h3wA:
undetectable
4dt8A-4h3wA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7o SERINE
ACETYLTRANSFERASE


(Vibrio cholerae)
PF00132
(Hexapep)
PF06426
(SATase_N)
5 GLY A 165
ALA A 168
ILE A 154
LEU A 156
ILE A 176
CYS  A 301 ( 4.6A)
None
None
None
None
1.10A 4dt8A-4h7oA:
undetectable
4dt8A-4h7oA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifd EXOSOME COMPLEX
COMPONENT RRP43


(Saccharomyces
cerevisiae)
PF01138
(RNase_PH)
5 GLY C 364
ILE C 299
ILE C 331
LEU C 334
ILE C 343
None
1.01A 4dt8A-4ifdC:
undetectable
4dt8A-4ifdC:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL


(Homo sapiens)
PF00171
(Aldedh)
5 GLY A 378
PRO A 403
ILE A 353
LEU A 354
ILE A 381
None
1.03A 4dt8A-4kwgA:
undetectable
4dt8A-4kwgA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lqz UNCHARACTERIZED
PROTEIN


(Staphylococcus
aureus)
PF16253
(DUF4909)
5 ALA A  65
ILE A  83
ILE A  38
LEU A 154
ILE A  48
None
1.05A 4dt8A-4lqzA:
undetectable
4dt8A-4lqzA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrj EFFECTOR NLEH1

(Escherichia
coli)
no annotation 5 GLY A 140
LYS A 159
ILE A 204
LEU A 246
ILE A 257
ANP  A 301 ( 3.9A)
ANP  A 301 (-3.6A)
ANP  A 301 (-4.3A)
None
ANP  A 301 (-4.2A)
0.86A 4dt8A-4lrjA:
7.6
4dt8A-4lrjA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 GLY A 318
PRO A 353
ILE A 356
LEU A 359
ILE A 332
None
1.10A 4dt8A-4mnaA:
undetectable
4dt8A-4mnaA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ


(Bacillus
subtilis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 GLY A 201
ALA A 200
ILE A 183
LEU A 374
ILE A   9
None
1.10A 4dt8A-4na3A:
undetectable
4dt8A-4na3A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pii N-GLYCOSYLASE/DNA
LYASE


(Pyrococcus
furiosus)
PF09171
(AGOG)
5 SER A 157
GLY A 154
ALA A 156
ILE A  43
ILE A  47
None
0.99A 4dt8A-4piiA:
undetectable
4dt8A-4piiA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr6 DNA POLYMERASE III
SUBUNIT BETA


(Bacillus
subtilis)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
5 ALA A 320
ILE A 266
ILE A 362
LEU A 341
ILE A 349
None
1.07A 4dt8A-4tr6A:
undetectable
4dt8A-4tr6A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1a ENOYL-COA DELTA
ISOMERASE 2


(Homo sapiens)
PF00378
(ECH_1)
5 SER A 162
GLY A 164
ILE A 118
LEU A 107
ILE A 137
None
1.09A 4dt8A-4u1aA:
undetectable
4dt8A-4u1aA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7v CELLULASE

(Xanthomonas
citri)
PF00150
(Cellulase)
5 GLY A 108
ALA A 107
ILE A 100
PRO A 135
LEU A  89
None
1.03A 4dt8A-4w7vA:
undetectable
4dt8A-4w7vA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh3 N-ACETYLHEXOSAMINE
1-KINASE


(Bifidobacterium
longum)
PF01636
(APH)
5 GLY A  28
ILE A  46
ILE A 105
LEU A 215
ILE A 227
ATP  A 401 (-3.3A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.9A)
GOL  A 404 ( 4.7A)
ATP  A 401 (-4.1A)
0.93A 4dt8A-4wh3A:
16.4
4dt8A-4wh3A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoq INTRACELLULAR SERINE
PROTEASE


(Bacillus
licheniformis)
PF00082
(Peptidase_S8)
5 GLY I 274
ALA I 273
ILE I 321
ILE I 425
ILE I 311
None
1.02A 4dt8A-4zoqI:
undetectable
4dt8A-4zoqI:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1


(Ovis aries)
PF00171
(Aldedh)
5 GLY A 378
PRO A 403
ILE A 353
LEU A 354
ILE A 381
None
0.99A 4dt8A-5abmA:
undetectable
4dt8A-5abmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE


(Thermoplasma
acidophilum)
PF01884
(PcrB)
5 GLY A 224
ALA A 227
ILE A  35
ILE A  67
ILE A  47
1GP  A 501 (-3.4A)
None
None
None
None
0.78A 4dt8A-5b69A:
undetectable
4dt8A-5b69A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)


(Agrobacterium
vitis)
PF13407
(Peripla_BP_4)
5 GLY A 288
ALA A 292
ILE A  35
PRO A  90
ILE A  66
None
1.07A 4dt8A-5dkvA:
undetectable
4dt8A-5dkvA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dnl IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE


(Pyrococcus
furiosus)
PF00475
(IGPD)
5 GLY A  63
ALA A  65
ILE A  14
LEU A  31
ILE A  44
None
0.98A 4dt8A-5dnlA:
undetectable
4dt8A-5dnlA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7s LON PROTEASE

(Meiothermus
taiwanensis)
PF05362
(Lon_C)
5 ALA A 502
ILE A 527
ILE A 574
LEU A 578
ILE A 550
None
1.08A 4dt8A-5e7sA:
undetectable
4dt8A-5e7sA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evj ARSENITE
METHYLTRANSFERASE


(Chlamydomonas
reinhardtii)
PF13847
(Methyltransf_31)
5 GLY A 113
ALA A  92
PRO A  77
ILE A  78
ILE A 167
None
0.96A 4dt8A-5evjA:
undetectable
4dt8A-5evjA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3


(Homo sapiens)
PF00171
(Aldedh)
5 GLY A 390
PRO A 415
ILE A 365
LEU A 366
ILE A 393
None
1.08A 4dt8A-5fhzA:
undetectable
4dt8A-5fhzA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1y PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41


(Homo sapiens)
PF00270
(DEAD)
5 GLY A 223
ALA A 225
ILE A 207
ILE A 209
ILE A 169
None
1.01A 4dt8A-5h1yA:
undetectable
4dt8A-5h1yA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it0 PHOSPHOSERINE
PHOSPHATASE


(Mycobacterium
avium)
PF12710
(HAD)
PF13740
(ACT_6)
5 SER A 275
GLY A 276
ALA A 296
LEU A 251
ILE A 281
None
1.10A 4dt8A-5it0A:
undetectable
4dt8A-5it0A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1


(Bos taurus)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
5 SER A1236
ILE A1107
ILE A1118
LEU A1121
ILE A1117
None
1.00A 4dt8A-5ujaA:
undetectable
4dt8A-5ujaA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uzh NAFOA.00085.B

(Naegleria
fowleri)
PF16363
(GDP_Man_Dehyd)
5 GLY A  40
PRO A 111
ILE A 106
LEU A 144
ILE A 114
NAP  A 402 (-3.2A)
None
None
None
None
1.07A 4dt8A-5uzhA:
undetectable
4dt8A-5uzhA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCE

(Pseudomonas
aeruginosa)
PF06833
(MdcE)
5 GLY A 232
ALA A 234
ILE A 133
ILE A  94
LEU A  16
None
1.00A 4dt8A-5vipA:
undetectable
4dt8A-5vipA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w11 GLUCANASE

(Thermothelomyces
thermophila)
no annotation 5 GLY A 106
ILE A  34
PRO A  12
ILE A  32
LEU A  91
None
1.09A 4dt8A-5w11A:
undetectable
4dt8A-5w11A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN


(Electrophorus
electricus)
PF00520
(Ion_trans)
PF06512
(Na_trans_assoc)
5 ALA A 668
ILE A 678
ILE A 680
LEU A1258
ILE A 676
None
1.07A 4dt8A-5xsyA:
undetectable
4dt8A-5xsyA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzx IMPORTIN SUBUNIT
ALPHA-3


(Homo sapiens)
PF00514
(Arm)
PF16186
(Arm_3)
5 SER A 113
GLY A 114
ILE A 107
LEU A  99
ILE A 142
None
0.98A 4dt8A-5xzxA:
undetectable
4dt8A-5xzxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbi PEPTIDE ASPARAGINYL
LIGASE


(Viola
canadensis)
no annotation 5 SER A 459
GLY A 456
ALA A 458
LEU A 442
ILE A 445
None
1.03A 4dt8A-5zbiA:
undetectable
4dt8A-5zbiA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amz 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E


(Acinetobacter
baumannii)
PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2)
5 SER A 200
GLY A 230
ILE A 208
HIS A 223
ILE A 214
None
0.98A 4dt8A-6amzA:
undetectable
4dt8A-6amzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5i RETINAL
DEHYDROGENASE 2


(Homo sapiens)
no annotation 5 GLY A 396
PRO A 421
ILE A 371
LEU A 372
ILE A 399
None
1.01A 4dt8A-6b5iA:
undetectable
4dt8A-6b5iA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus)
no annotation 5 GLY A 141
LYS A 149
ILE A 192
LEU A 421
ILE A 138
None
1.01A 4dt8A-6begA:
undetectable
4dt8A-6begA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus)
no annotation 5 ALA A 216
LYS A 226
PRO A 258
HIS A 379
ASP A 393
GNP  A 500 ( 3.9A)
GNP  A 500 (-2.7A)
None
MG  A 700 ( 3.2A)
MG  A 702 (-1.7A)
1.04A 4dt8A-6ceyA:
30.7
4dt8A-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus)
no annotation 8 GLY A 209
ALA A 216
ILE A 224
LYS A 226
PRO A 258
ILE A 277
HIS A 379
ILE A 392
GNP  A 500 ( 4.3A)
GNP  A 500 ( 3.9A)
GNP  A 500 (-3.7A)
GNP  A 500 (-2.7A)
None
GNP  A 500 (-3.8A)
MG  A 700 ( 3.2A)
GNP  A 500 (-3.9A)
0.63A 4dt8A-6ceyA:
30.7
4dt8A-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus)
no annotation 8 GLY A 209
ALA A 216
ILE A 224
PRO A 258
ILE A 277
HIS A 379
LEU A 381
ILE A 392
GNP  A 500 ( 4.3A)
GNP  A 500 ( 3.9A)
GNP  A 500 (-3.7A)
None
GNP  A 500 (-3.8A)
MG  A 700 ( 3.2A)
None
GNP  A 500 (-3.9A)
0.69A 4dt8A-6ceyA:
30.7
4dt8A-6ceyA:
14.38