SIMILAR PATTERNS OF AMINO ACIDS FOR 4DRJ_A_RAPA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhe POLYGALACTURONASE

(Pectobacterium
carotovorum) 		PF00295
(Glyco_hydro_28) 		5 ASP A 224
VAL A 267
ILE A 242
ILE A 204
PHE A 247
 None
 1.17A 4drjA-1bheA:
undetectable		 4drjA-1bheA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		7 ASP A 142
PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
 None
 1.08A 4drjA-1fd9A:
16.9		 4drjA-1fd9A:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		8 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
 None
 0.55A 4drjA-1fd9A:
16.9		 4drjA-1fd9A:
30.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		9 TYR A  26
ASP A  37
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
ILE A  91
PHE A  99
 None
 0.43A 4drjA-1fkkA:
19.3		 4drjA-1fkkA:
40.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		9 TYR A  26
PHE A  46
GLU A  54
VAL A  55
ILE A  56
TRP A  59
TYR A  82
ILE A  91
PHE A  99
 None
 0.60A 4drjA-1fkkA:
19.3		 4drjA-1fkkA:
40.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		5 TYR A  26
PHE A  46
GLU A  54
VAL A  55
ILE A  90
 None
 1.20A 4drjA-1fkkA:
19.3		 4drjA-1fkkA:
40.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		5 TYR A 163
PHE A 151
VAL A 140
TRP A  96
PHE A 166
 None
 1.34A 4drjA-1hxjA:
undetectable		 4drjA-1hxjA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icp 12-OXOPHYTODIENOATE
REDUCTASE 1

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		5 TYR A 300
GLU A 277
VAL A 275
ILE A 240
ILE A 186
 None
 1.24A 4drjA-1icpA:
undetectable		 4drjA-1icpA:
17.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		7 GLU A 118
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.43A 4drjA-1jvwA:
16.1		 4drjA-1jvwA:
32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		7 TYR A  92
ASP A 103
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.62A 4drjA-1jvwA:
16.1		 4drjA-1jvwA:
32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		7 TYR A  92
PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.91A 4drjA-1jvwA:
16.1		 4drjA-1jvwA:
32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		7 TYR A  92
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.36A 4drjA-1jvwA:
16.1		 4drjA-1jvwA:
32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		5 TYR A  57
PHE A  77
ILE A  87
TRP A  90
ILE A 122
 None
 1.07A 4drjA-1kt1A:
17.9		 4drjA-1kt1A:
60.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		6 TYR A  57
PHE A  77
ILE A  87
TRP A  90
TYR A 113
PHE A 130
 None
 0.85A 4drjA-1kt1A:
17.9		 4drjA-1kt1A:
60.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		5 TYR A  57
PHE A  77
VAL A  86
TRP A  90
ILE A 122
 None
 0.91A 4drjA-1kt1A:
17.9		 4drjA-1kt1A:
60.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		6 TYR A  57
PHE A  77
VAL A  86
TRP A  90
TYR A 113
PHE A 130
 None
 0.76A 4drjA-1kt1A:
17.9		 4drjA-1kt1A:
60.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n1a FKBP52

(Homo sapiens) 		PF00254
(FKBP_C) 		10 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.59A 4drjA-1n1aA:
22.6		 4drjA-1n1aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pbk FKBP25

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A 135
ASP A 146
VAL A 171
ILE A 172
TRP A 175
TYR A 198
ILE A 208
PHE A 216
 RAP  A 225 (-3.9A)
RAP  A 225 (-3.0A)
RAP  A 225 (-3.5A)
RAP  A 225 (-3.9A)
RAP  A 225 (-3.4A)
RAP  A 225 (-4.6A)
RAP  A 225 ( 4.9A)
None
 0.26A 4drjA-1pbkA:
19.1		 4drjA-1pbkA:
38.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		6 PHE A 168
ILE A 174
TRP A 177
TYR A 200
ILE A 208
PHE A 216
 None
 1.41A 4drjA-1q6hA:
16.5		 4drjA-1q6hA:
29.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		8 TYR A 146
ASP A 157
VAL A 173
ILE A 174
TRP A 177
TYR A 200
ILE A 208
PHE A 216
 None
 0.58A 4drjA-1q6hA:
16.5		 4drjA-1q6hA:
29.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r9h FK506 BINDING
PROTEIN FAMILY

(Caenorhabditis
elegans) 		PF00254
(FKBP_C) 		9 TYR A  40
ASP A  51
PHE A  60
VAL A  69
ILE A  70
TRP A  73
TYR A  96
ILE A 105
PHE A 113
 None
 0.57A 4drjA-1r9hA:
23.2		 4drjA-1r9hA:
53.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.08A 4drjA-1ry2A:
undetectable		 4drjA-1ry2A:
12.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Arabidopsis
thaliana) 		PF00254
(FKBP_C) 		9 TYR A  37
ASP A  48
GLU A  65
VAL A  66
ILE A  67
TRP A  70
TYR A  99
ILE A 113
PHE A 121
 None
 0.55A 4drjA-1u79A:
18.5		 4drjA-1u79A:
34.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whu 3'-5' RNA
EXONUCLEASE
POLYNUCLEOTIDE
PHOSPHORYLASE

(Mus musculus) 		PF03726
(PNPase) 		5 PHE A 349
VAL A 314
ILE A 317
ILE A 291
PHE A 341
 None
 1.27A 4drjA-1whuA:
undetectable		 4drjA-1whuA:
22.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yat FK506 BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		9 TYR A  26
ASP A  37
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
ILE A  91
PHE A  99
 FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.3A)
FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.4A)
FK5  A 108 ( 3.7A)
FK5  A 108 ( 3.6A)
FK5  A 108 ( 4.7A)
None
None
 0.35A 4drjA-1yatA:
21.0		 4drjA-1yatA:
44.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjg GTP-BINDING PROTEIN
ENGA

(Bacillus
subtilis) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		5 TYR A 384
ASP A 132
VAL A 388
ILE A 130
PHE A 398
 None
 1.33A 4drjA-2hjgA:
undetectable		 4drjA-2hjgA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv8 AP-2 COMPLEX SUBUNIT
BETA-1

(Homo sapiens) 		PF02883
(Alpha_adaptinC2)
PF09066
(B2-adapt-app_C) 		5 PHE A 762
GLU A 922
VAL A 923
ILE A 927
PHE A 826
 None
 0.91A 4drjA-2iv8A:
undetectable		 4drjA-2iv8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 PHE A 312
GLU A 318
VAL A 319
ILE A 323
ILE A 420
 None
 1.26A 4drjA-2iyoA:
undetectable		 4drjA-2iyoA:
16.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lpv FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Aedes aegypti) 		PF00254
(FKBP_C) 		6 TYR A  27
PHE A  47
GLU A  55
VAL A  56
ILE A  57
TRP A  60
 None
 0.86A 4drjA-2lpvA:
16.6		 4drjA-2lpvA:
38.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lpv FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Aedes aegypti) 		PF00254
(FKBP_C) 		6 TYR A  27
PHE A  47
GLU A  55
VAL A  56
TRP A  60
ILE A  92
 None
 1.00A 4drjA-2lpvA:
16.6		 4drjA-2lpvA:
38.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbc FK506-BINDING
PROTEIN 2

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A  86
TRP A  89
TYR A 112
ILE A 121
PHE A 129
 PEG  A 201 (-4.4A)
None
PEG  A 201 ( 3.9A)
PEG  A 201 (-3.6A)
PEG  A 201 (-3.8A)
PEG  A 201 (-3.7A)
None
None
None
 0.77A 4drjA-2pbcA:
15.4		 4drjA-2pbcA:
36.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 ASP A  66
VAL A  82
ILE A  83
TRP A  86
PHE A 126
 RAP  A 138 (-2.7A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
RAP  A 138 ( 4.7A)
 0.79A 4drjA-2vcdA:
14.5		 4drjA-2vcdA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A  55
ASP A  66
VAL A  82
ILE A  83
TRP A  86
 RAP  A 138 (-2.6A)
RAP  A 138 (-2.7A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
 0.76A 4drjA-2vcdA:
14.5		 4drjA-2vcdA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A  55
VAL A  82
ILE A  83
TRP A  86
TYR A 109
 RAP  A 138 (-2.6A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
RAP  A 138 (-3.8A)
 0.65A 4drjA-2vcdA:
14.5		 4drjA-2vcdA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE

(Plasmodium
falciparum) 		PF00254
(FKBP_C) 		10 TYR A  44
ASP A  56
PHE A  65
GLU A  73
VAL A  74
ILE A  75
TRP A  78
TYR A 101
ILE A 110
PHE A 118
 FK5  A 501 (-4.1A)
FK5  A 501 (-3.4A)
FK5  A 501 (-4.1A)
None
FK5  A 501 (-3.5A)
FK5  A 501 (-4.3A)
FK5  A 501 (-3.3A)
FK5  A 501 (-4.7A)
None
FK5  A 501 (-4.8A)
 0.55A 4drjA-2vn1A:
21.3		 4drjA-2vn1A:
39.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		9 TYR A  33
ASP A  44
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
 None
 0.63A 4drjA-2y78A:
19.1		 4drjA-2y78A:
46.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywi HYPOTHETICAL
CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF00578
(AhpC-TSA) 		5 TYR A 133
ASP A 131
GLU A 119
VAL A 120
ILE A  52
 None
 1.34A 4drjA-2ywiA:
undetectable		 4drjA-2ywiA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE

(Pseudomonas sp.
ATCC 19121) 		PF00155
(Aminotran_1_2) 		5 ASP A 286
PHE A 204
ILE A 210
ILE A 181
PHE A 250
 PLP  A 900 (-3.2A)
PLP  A 900 (-4.2A)
None
None
None
 1.01A 4drjA-2zy2A:
undetectable		 4drjA-2zy2A:
14.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b7x FK506-BINDING
PROTEIN 6

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  61
ASP A  73
GLU A  96
TYR A 118
ILE A 127
 None
 1.22A 4drjA-3b7xA:
17.5		 4drjA-3b7xA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b7x FK506-BINDING
PROTEIN 6

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  61
ASP A  73
TYR A 118
ILE A 127
PHE A 135
 None
 0.90A 4drjA-3b7xA:
17.5		 4drjA-3b7xA:
37.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg3 UPF0100 PROTEIN
PH0151

(Pyrococcus
horikoshii) 		PF13531
(SBP_bac_11) 		5 GLU A 114
VAL A 116
ILE A 117
ILE A 139
PHE A 119
 None
 1.25A 4drjA-3cg3A:
undetectable		 4drjA-3cg3A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdi PROCESSING PROTEASE

(Bacillus
halodurans) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 ASP A 100
PHE A  67
ILE A  26
LYS A 199
ILE A 200
 None
 1.29A 4drjA-3hdiA:
undetectable		 4drjA-3hdiA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4u BINDING COMPONENT OF
ABC TRANSPORTER

(Wolinella
succinogenes) 		PF00497
(SBP_bac_3) 		5 GLU A 187
VAL A  89
ILE A  87
TYR A  86
PHE A 225
 None
 1.26A 4drjA-3k4uA:
undetectable		 4drjA-3k4uA:
25.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.72A 4drjA-3o5dA:
22.3		 4drjA-3o5dA:
61.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 ILE A  87
TRP A  90
TYR A 113
LYS A 121
ILE A 122
 None
 0.98A 4drjA-3o5eA:
22.8		 4drjA-3o5eA:
61.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TYR A 113
ILE A 122
PHE A 130
 None
 0.74A 4drjA-3o5eA:
22.8		 4drjA-3o5eA:
61.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.74A 4drjA-3o5eA:
22.8		 4drjA-3o5eA:
61.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		9 TYR A  43
ASP A  55
PHE A  64
GLU A  72
VAL A  73
ILE A  74
TRP A  77
ILE A 109
PHE A 117
 None
 0.64A 4drjA-3pa7A:
20.8		 4drjA-3pa7A:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		9 TYR A  43
PHE A  64
GLU A  72
VAL A  73
ILE A  74
TRP A  77
TYR A 100
ILE A 109
PHE A 117
 None
 0.47A 4drjA-3pa7A:
20.8		 4drjA-3pa7A:
38.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.11A 4drjA-3sqwA:
undetectable		 4drjA-3sqwA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 TYR A 569
VAL A 210
ILE A 224
TYR A 226
ILE A 200
 None
 1.28A 4drjA-3um6A:
undetectable		 4drjA-3um6A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1z ENDONUCLEASE
BSE634IR

(Geobacillus
stearothermophilus) 		PF07832
(Bse634I) 		5 ASP A 173
PHE A  27
GLU A  80
VAL A  81
ILE A  85
 None
 1.25A 4drjA-3v1zA:
undetectable		 4drjA-3v1zA:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		7 ASP A 324
VAL A 341
ILE A 342
TRP A 345
TYR A 368
ILE A 376
PHE A 384
 None
 0.74A 4drjA-4bf8A:
17.1		 4drjA-4bf8A:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		7 GLU A 340
VAL A 341
ILE A 342
TRP A 345
TYR A 368
ILE A 376
PHE A 384
 None
 1.08A 4drjA-4bf8A:
17.1		 4drjA-4bf8A:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		6 PHE A 332
GLU A 340
VAL A 341
ILE A 342
TRP A 345
PHE A 384
 None
 1.22A 4drjA-4bf8A:
17.1		 4drjA-4bf8A:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		7 TYR A 313
ASP A 324
PHE A 332
VAL A 341
ILE A 342
TRP A 345
PHE A 384
 None
 0.83A 4drjA-4bf8A:
17.1		 4drjA-4bf8A:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		7 TYR A 313
ASP A 324
VAL A 341
ILE A 342
TRP A 345
TYR A 368
PHE A 384
 None
 0.77A 4drjA-4bf8A:
17.1		 4drjA-4bf8A:
35.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		5 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.14A 4drjA-4db4A:
undetectable		 4drjA-4db4A:
19.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dip PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  52
TRP A  88
TYR A 111
ILE A 119
PHE A 127
 None
 0.57A 4drjA-4dipA:
17.0		 4drjA-4dipA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dz3 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		9 TYR A  33
ASP A  44
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
 FK5  A 201 ( 3.9A)
FK5  A 201 (-3.5A)
FK5  A 201 (-4.1A)
FK5  A 201 ( 3.6A)
FK5  A 201 (-3.8A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.7A)
None
FK5  A 201 (-4.8A)
 0.32A 4drjA-4dz3A:
19.8		 4drjA-4dz3A:
46.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqg TRANSCRIPTION
ELONGATION REGULATOR
1

(Homo sapiens) 		PF01846
(FF) 		5 TYR A 116
ASP A  75
GLU A  88
VAL A  89
ILE A  93
 None
 1.03A 4drjA-4fqgA:
undetectable		 4drjA-4fqgA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN

(Enterococcus
faecalis) 		PF00497
(SBP_bac_3) 		5 GLU A  63
VAL A  64
ILE A  27
ILE A  78
PHE A 208
 None
 1.34A 4drjA-4g4pA:
undetectable		 4drjA-4g4pA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 ASP B 851
GLU B 717
VAL B 718
ILE B 719
TYR B 847
 None
 0.71A 4drjA-4gnkB:
undetectable		 4drjA-4gnkB:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Eubacterium
ventriosum) 		PF13306
(LRR_5) 		5 PHE A 337
VAL A 346
ILE A 369
ILE A 375
PHE A 383
 None
 1.23A 4drjA-4h09A:
undetectable		 4drjA-4h09A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h19 MANDELATE RACEMASE

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A 144
PHE A 168
VAL A 342
ILE A 340
ILE A 332
 None
None
None
None
CL  A 404 (-4.3A)
 1.27A 4drjA-4h19A:
undetectable		 4drjA-4h19A:
18.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  26
ASP A  37
PHE A  46
ILE A  56
TYR A  82
ILE A  91
PHE A  99
 None
 0.71A 4drjA-4iqcA:
19.0		 4drjA-4iqcA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  26
PHE A  46
GLU A  54
VAL A  55
ILE A  56
TYR A  82
ILE A  91
PHE A  99
 None
 0.66A 4drjA-4iqcA:
19.0		 4drjA-4iqcA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.62A 4drjA-4lawA:
23.7		 4drjA-4lawA:
87.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  57
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.49A 4drjA-4lawA:
23.7		 4drjA-4lawA:
87.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4msp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14

(Homo sapiens) 		PF00254
(FKBP_C)
PF13499
(EF-hand_7) 		5 GLU A  64
TYR A  92
LYS A  99
ILE A 100
PHE A 108
 None
 0.94A 4drjA-4mspA:
17.4		 4drjA-4mspA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4msp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14

(Homo sapiens) 		PF00254
(FKBP_C)
PF13499
(EF-hand_7) 		6 TYR A  33
TRP A  69
TYR A  92
LYS A  99
ILE A 100
PHE A 108
 None
 0.89A 4drjA-4mspA:
17.4		 4drjA-4mspA:
27.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nnr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2

(Homo sapiens) 		PF00254
(FKBP_C) 		10 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A  86
TRP A  89
TYR A 112
LYS A 120
ILE A 121
PHE A 129
 FK5  A 201 (-4.1A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.0A)
FK5  A 201 (-3.4A)
FK5  A 201 (-3.8A)
FK5  A 201 (-3.5A)
FK5  A 201 (-4.5A)
FK5  A 201 (-3.5A)
None
FK5  A 201 (-4.9A)
 0.43A 4drjA-4nnrA:
16.1		 4drjA-4nnrA:
40.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odm PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD

(Thermus
thermophilus) 		PF00254
(FKBP_C) 		5 TYR A  13
ASP A  23
ILE A  37
TYR A  63
PHE A 128
 None
 0.48A 4drjA-4odmA:
11.3		 4drjA-4odmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA

(Homo sapiens;
Thermus
thermophilus) 		PF00254
(FKBP_C) 		6 TYR A  13
ASP A  23
ILE A  37
TYR A  63
ILE A  72
PHE A  80
 FK5  A 201 ( 3.6A)
FK5  A 201 (-3.6A)
FK5  A 201 (-3.9A)
FK5  A 201 (-4.4A)
None
FK5  A 201 ( 4.8A)
 0.35A 4drjA-4odrA:
13.0		 4drjA-4odrA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovx XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

(Planctopirus
limnophila) 		PF01261
(AP_endonuc_2) 		5 TYR A 267
PHE A 222
VAL A 283
ILE A  48
ILE A 298
 None
 1.34A 4drjA-4ovxA:
undetectable		 4drjA-4ovxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 ASP B 851
GLU B 717
VAL B 718
ILE B 719
TYR B 847
 None
 1.29A 4drjA-4qj4B:
undetectable		 4drjA-4qj4B:
10.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TYR A 113
PHE A 130
 None
 0.75A 4drjA-4r0xA:
23.2		 4drjA-4r0xA:
68.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.66A 4drjA-4r0xA:
23.2		 4drjA-4r0xA:
68.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7l CAS6B

(Methanococcus
maripaludis) 		PF17262
(DUF5328) 		5 TYR A  31
GLU A  75
ILE A  63
TYR A  10
PHE A  27
 None
 1.27A 4drjA-4z7lA:
undetectable		 4drjA-4z7lA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7l CAS6B

(Methanococcus
maripaludis) 		PF17262
(DUF5328) 		5 TYR A  31
ILE A  63
TYR A  10
ILE A  94
PHE A  27
 None
 1.33A 4drjA-4z7lA:
undetectable		 4drjA-4z7lA:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Coccidioides
immitis) 		PF00254
(FKBP_C) 		9 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.32A 4drjA-5b8iC:
18.4		 4drjA-5b8iC:
36.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5crj TRANSCRIPTION
TERMINATION FACTOR
1, MITOCHONDRIAL

(Homo sapiens) 		PF02536
(mTERF) 		5 TYR O 317
ILE O 296
LYS O 331
ILE O 332
PHE O 313
 None
 1.04A 4drjA-5crjO:
undetectable		 4drjA-5crjO:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsb RNA POLYMERASE

(Andes
orthohantavirus) 		no annotation 5 PHE A  92
VAL A 135
ILE A 154
ILE A 101
PHE A 108
 None
 1.29A 4drjA-5hsbA:
undetectable		 4drjA-5hsbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  26
ASP A  37
PHE A  46
GLU A  54
VAL A  55
ILE A  56
TRP A  59
TYR A  82
PHE A 146
 None
 0.56A 4drjA-5i7pA:
17.6		 4drjA-5i7pA:
28.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE 16
KDA PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE,PEPTIDYL-P
ROLYL CIS-TRANS
ISOMERASE FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  26
ASP A  37
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
PHE A 147
 None
 0.49A 4drjA-5i7qA:
17.9		 4drjA-5i7qA:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE 16
KDA PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE,PEPTIDYL-P
ROLYL CIS-TRANS
ISOMERASE FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  26
PHE A  46
GLU A  54
VAL A  55
ILE A  56
TRP A  59
TYR A  82
PHE A 147
 None
 0.63A 4drjA-5i7qA:
17.9		 4drjA-5i7qA:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		8 TYR A  30
ASP A  41
PHE A  50
VAL A  59
ILE A  60
TRP A  63
TYR A  97
ILE A 102
 None
 1.31A 4drjA-5i98A:
18.0		 4drjA-5i98A:
36.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		9 TYR A  30
ASP A  41
PHE A  50
VAL A  59
ILE A  60
TRP A  63
TYR A  97
ILE A 106
PHE A 114
 None
 0.49A 4drjA-5i98A:
18.0		 4drjA-5i98A:
36.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j6e FK506-BINDING
PROTEIN 1A

(Aspergillus
fumigatus) 		PF00254
(FKBP_C) 		9 TYR A  27
ASP A  38
PHE A  47
VAL A  56
ILE A  57
TRP A  60
TYR A  83
ILE A  92
PHE A 100
 None
 0.57A 4drjA-5j6eA:
19.5		 4drjA-5j6eA:
41.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcv LMO2181 PROTEIN

(Listeria
monocytogenes) 		PF04203
(Sortase) 		5 ASP A 125
VAL A  75
ILE A  89
TYR A 161
ILE A 221
 None
 1.07A 4drjA-5jcvA:
undetectable		 4drjA-5jcvA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lzk PROTEIN FAM83B

(Homo sapiens) 		PF07894
(DUF1669) 		5 VAL A 167
ILE A 166
LYS A 136
ILE A 139
PHE A 157
 None
None
None
EDO  A 307 ( 4.9A)
None
 0.81A 4drjA-5lzkA:
undetectable		 4drjA-5lzkA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msz THERMOBIA DOMESTICA
DOMESTICA AA15

(Thermobia
domestica) 		no annotation 5 ASP A  84
VAL A  72
ILE A 190
TYR A  75
ILE A  81
 None
 1.10A 4drjA-5mszA:
undetectable		 4drjA-5mszA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8t UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei;
Saccharomyces
cerevisiae) 		no annotation 9 TYR A  33
ASP A  44
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
 8ZV  A 201 (-3.8A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.6A)
8ZV  A 201 (-4.0A)
8ZV  A 201 (-3.3A)
8ZV  A 201 (-4.6A)
8ZV  A 201 ( 4.8A)
8ZV  A 201 (-4.6A)
 0.29A 4drjA-5v8tA:
19.7		 4drjA-5v8tA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 319
TYR A 376
LYS A 350
ILE A 347
PHE A 311
 None
 1.16A 4drjA-5vdkA:
undetectable		 4drjA-5vdkA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpi HSVA

(Erwinia
amylovora) 		no annotation 5 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.33A 4drjA-5wpiA:
undetectable		 4drjA-5wpiA:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		8 TYR A 147
ASP A 158
PHE A 166
ILE A 172
TRP A 175
TYR A 198
ILE A 207
PHE A 215
 TLA  A 301 ( 4.4A)
TLA  A 301 (-3.7A)
TLA  A 301 ( 4.6A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
None
None
None
 1.05A 4drjA-5xb0A:
16.5		 4drjA-5xb0A:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		8 TYR A 147
ASP A 158
VAL A 171
ILE A 172
TRP A 175
TYR A 198
ILE A 207
PHE A 215
 TLA  A 301 ( 4.4A)
TLA  A 301 (-3.7A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
None
None
None
 0.67A 4drjA-5xb0A:
16.5		 4drjA-5xb0A:
31.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii) 		no annotation 5 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
 None
 1.25A 4drjA-5z0yA:
undetectable		 4drjA-5z0yA:
19.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 10 TYR A  38
ASP A  49
PHE A  58
GLU A  66
VAL A  67
ILE A  68
TRP A  71
TYR A  94
ILE A 103
PHE A 111
 None
 0.72A 4drjA-6b4pA:
21.1		 4drjA-6b4pA:
42.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE

(Bacillus
anthracis) 		no annotation 5 TYR A 181
PHE A 299
GLU A 251
VAL A 252
ILE A 256
 None
 1.34A 4drjA-6bi4A:
undetectable		 4drjA-6bi4A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0f GLUTATHIONE
S-TRANSFERASE

(Escherichia
coli) 		PF00043
(GST_C)
PF13409
(GST_N_2) 		4 LEU A  12
SER A  14
THR A 152
TYR A 157
 None
 1.01A 4drjB-1a0fA:
2.4		 4drjB-1a0fA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fj7 NUCLEOLIN RBD1

(Mesocricetus
auratus) 		PF00076
(RRM_1) 		4 LEU A  71
SER A  67
THR A  15
ASP A  51
 None
 1.04A 4drjB-1fj7A:
undetectable		 4drjB-1fj7A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gdh D-GLYCERATE
DEHYDROGENASE

(Hyphomicrobium
methylovorum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A 197
SER A 196
THR A 192
ASP A 174
 None
 0.99A 4drjB-1gdhA:
undetectable		 4drjB-1gdhA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		4 LEU A  97
THR A  62
TYR A  96
PHE A  35
 None
NAG  A1996 ( 4.3A)
None
None
 1.08A 4drjB-1gqrA:
undetectable		 4drjB-1gqrA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwn EBULIN

(Sambucus ebulus) 		PF00161
(RIP) 		4 LEU A 191
THR A 226
ASP A 224
TYR A 223
 None
 1.06A 4drjB-1hwnA:
undetectable		 4drjB-1hwnA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9a OLIGORIBONUCLEASE

(Haemophilus
influenzae) 		PF00929
(RNase_T) 		4 LEU A  16
THR A  84
TYR A 122
PHE A 118
 None
 0.86A 4drjB-1j9aA:
undetectable		 4drjB-1j9aA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks5 ENDOGLUCANASE A

(Aspergillus
niger) 		PF01670
(Glyco_hydro_12) 		4 LEU A 121
SER A 165
THR A 138
TRP A 144
 None
 1.10A 4drjB-1ks5A:
undetectable		 4drjB-1ks5A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 LEU A 170
PHE A 125
ASP A 188
TYR A 187
 None
 0.93A 4drjB-1lrwA:
undetectable		 4drjB-1lrwA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE

(Arabidopsis
thaliana) 		PF16363
(GDP_Man_Dehyd) 		4 LEU A 212
SER A 163
PHE A 166
THR A 176
 NDP  A 701 (-4.9A)
GDR  A 801 (-3.5A)
None
None
 0.95A 4drjB-1n7gA:
undetectable		 4drjB-1n7gA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		4 LEU A 299
PHE A 307
ASP A 458
PHE A 298
 None
 1.09A 4drjB-1qhbA:
undetectable		 4drjB-1qhbA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sed HYPOTHETICAL PROTEIN
YHAI

(Bacillus
subtilis) 		PF08963
(DUF1878) 		4 LEU A  53
THR A  67
ASP A  69
PHE A  75
 None
 1.05A 4drjB-1sedA:
1.9		 4drjB-1sedA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjy SUGAR TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF13407
(Peripla_BP_4) 		4 THR A 198
ASP A 196
TYR A 194
PHE A 192
 None
 0.93A 4drjB-1tjyA:
undetectable		 4drjB-1tjyA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tue REGULATORY PROTEIN
E2

(Alphapapillomavirus
7) 		PF00508
(PPV_E2_N) 		4 THR B 149
TRP B 150
ASP B 151
TYR B 142
 None
 1.08A 4drjB-1tueB:
4.3		 4drjB-1tueB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybi NON-TOXIN
HAEMAGGLUTININ HA34

(Clostridium
botulinum) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		4 SER A  63
THR A  17
TRP A  48
TYR A  29
 None
 0.80A 4drjB-1ybiA:
undetectable		 4drjB-1ybiA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		4 LEU A 492
PHE A 233
THR A 508
ASP A 508
 None
 0.81A 4drjB-1ygpA:
undetectable		 4drjB-1ygpA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yk9 ADENYLATE CYCLASE

(Mycobacterium
tuberculosis) 		PF00211
(Guanylate_cyc) 		4 LEU A 276
PHE A 283
THR A 327
PHE A 260
 None
 0.92A 4drjB-1yk9A:
undetectable		 4drjB-1yk9A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwo RNA SILENCING
SUPPRESSOR

(Beet yellows
virus) 		PF11479
(Suppressor_P21) 		4 LEU A 165
SER A 169
THR A 101
ASP A 104
 None
 0.88A 4drjB-2cwoA:
2.1		 4drjB-2cwoA:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gaq FKBP12-RAPAMYCIN
COMPLEX-ASSOCIATED
PROTEIN

(Homo sapiens) 		PF08771
(FRB_dom) 		4 LEU A  17
THR A  84
TYR A  91
PHE A  94
 None
 0.75A 4drjB-2gaqA:
12.3		 4drjB-2gaqA:
90.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 LEU A 139
SER A 249
THR A  73
ASP A  67
 None
PMS  A 601 (-1.7A)
None
None
 1.08A 4drjB-2gkoA:
undetectable		 4drjB-2gkoA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id0 EXORIBONUCLEASE 2

(Escherichia
coli) 		PF00575
(S1)
PF00773
(RNB)
PF08206
(OB_RNB) 		4 LEU A 282
THR A 494
TRP A 495
ASP A 504
 None
 1.06A 4drjB-2id0A:
undetectable		 4drjB-2id0A:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		4 LEU A 246
SER A 242
ASP A 236
TYR A 237
 None
 1.06A 4drjB-2j3zA:
undetectable		 4drjB-2j3zA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn5 HYPOTHETICAL PROTEIN
EF_2215

(Enterococcus
faecalis) 		PF08327
(AHSA1) 		4 LEU A 152
PHE A 144
ASP A 117
TYR A 151
 None
 1.00A 4drjB-2nn5A:
undetectable		 4drjB-2nn5A:
17.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2npu FKBP12-RAPAMYCIN
COMPLEX-ASSOCIATED
PROTEIN

(Homo sapiens) 		PF08771
(FRB_dom) 		4 SER A2035
TRP A2101
ASP A2102
TYR A2105
 None
 0.92A 4drjB-2npuA:
14.1		 4drjB-2npuA:
91.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2npu FKBP12-RAPAMYCIN
COMPLEX-ASSOCIATED
PROTEIN

(Homo sapiens) 		PF08771
(FRB_dom) 		4 THR A2098
TRP A2101
ASP A2102
TYR A2105
 None
 0.81A 4drjB-2npuA:
14.1		 4drjB-2npuA:
91.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o42 M11L PROTEIN

(Myxoma virus) 		PF11099
(M11L) 		5 LEU A   5
SER A   3
THR A  22
ASP A  11
TYR A  10
 None
 1.38A 4drjB-2o42A:
undetectable		 4drjB-2o42A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p03 ALPHA-2-MACROGLOBULI
N
RECEPTOR-ASSOCIATED
PROTEIN

(Homo sapiens) 		PF06400
(Alpha-2-MRAP_N)
PF06401
(Alpha-2-MRAP_C) 		4 LEU A 308
SER A 312
TRP A 227
ASP A 225
 None
 1.09A 4drjB-2p03A:
3.4		 4drjB-2p03A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p12 HYPOTHETICAL PROTEIN
DUF402

(Rhodococcus
jostii) 		PF04167
(DUF402) 		4 LEU A  43
SER A  59
ASP A  34
PHE A  16
 None
 1.08A 4drjB-2p12A:
undetectable		 4drjB-2p12A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlt (DL)-GLYCEROL-3-PHOS
PHATASE 1

(Saccharomyces
cerevisiae) 		PF13419
(HAD_2) 		4 LEU A 124
PHE A 147
THR A 136
ASP A  39
 None
None
SO4  A 280 (-3.7A)
CA  A 278 ( 2.2A)
 0.97A 4drjB-2qltA:
undetectable		 4drjB-2qltA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0p TYPE 2A
PHOSPHATASE-ASSOCIAT
ED PROTEIN 42

(Saccharomyces
cerevisiae) 		PF04177
(TAP42) 		4 LEU A 208
SER A 212
THR A 116
ASP A 120
 None
 1.07A 4drjB-2v0pA:
2.9		 4drjB-2v0pA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A 189
SER A 137
THR A 106
TYR A 135
 None
EDO  A1510 ( 4.5A)
None
GOL  A1511 (-4.5A)
 0.96A 4drjB-2w40A:
undetectable		 4drjB-2w40A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3h K5 LYASE

(Escherichia
virus K1-5) 		no annotation 4 THR A 414
ASP A 417
TYR A 419
PHE A 399
 None
 1.07A 4drjB-2x3hA:
undetectable		 4drjB-2x3hA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmo LMO2642 PROTEIN

(Listeria
monocytogenes) 		PF00149
(Metallophos) 		4 LEU A 194
SER A 182
TRP A 223
ASP A 222
 None
 1.10A 4drjB-2xmoA:
2.4		 4drjB-2xmoA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y25 MYOMESIN

(Homo sapiens) 		PF07679
(I-set) 		4 LEU A1592
THR A1656
ASP A1658
TYR A1644
 None
 1.05A 4drjB-2y25A:
undetectable		 4drjB-2y25A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 LEU A 131
PHE A 116
THR A 163
ASP A  30
 None
 1.07A 4drjB-2y9xA:
undetectable		 4drjB-2y9xA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		4 SER A 656
PHE A 659
ASP A 624
TYR A 627
 None
 0.95A 4drjB-3a6pA:
4.2		 4drjB-3a6pA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d43 SPHERICASE

(Lysinibacillus
sphaericus) 		PF00082
(Peptidase_S8) 		4 LEU A 140
SER A 250
THR A  73
ASP A  67
 None
 1.07A 4drjB-3d43A:
undetectable		 4drjB-3d43A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwk PENICILLIN-BINDING
PROTEIN 2

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		4 SER A 526
THR A 543
ASP A 541
TYR A 540
 None
 0.96A 4drjB-3dwkA:
undetectable		 4drjB-3dwkA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0j DNA POLYMERASE
SUBUNIT DELTA-3

(Homo sapiens) 		PF09507
(CDC27) 		5 LEU B 126
SER B 124
THR B 117
ASP B 118
TYR B  28
 None
 1.40A 4drjB-3e0jB:
undetectable		 4drjB-3e0jB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e38 TWO-DOMAIN PROTEIN
CONTAINING PREDICTED
PHP-LIKE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bacteroides
vulgatus) 		PF16392
(DUF5001) 		4 LEU A  68
THR A  57
ASP A  61
TYR A  64
 None
 0.82A 4drjB-3e38A:
undetectable		 4drjB-3e38A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7o SERINE PROTEASE

(Purpureocillium
lilacinum) 		PF00082
(Peptidase_S8) 		4 LEU A 136
SER A 227
THR A  74
ASP A  68
 None
 0.99A 4drjB-3f7oA:
undetectable		 4drjB-3f7oA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdi UNCHARACTERIZED
PROTEIN

(Eubacterium
ventriosum) 		PF13189
(Cytidylate_kin2) 		4 LEU A 121
SER A  14
THR A 186
PHE A 119
 None
SO4  A2003 (-3.0A)
None
None
 0.91A 4drjB-3fdiA:
undetectable		 4drjB-3fdiA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnr ARGINYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00750
(tRNA-synt_1d)
PF05746
(DALR_1) 		4 LEU A 192
PHE A 200
TRP A 216
ASP A 215
 None
 0.77A 4drjB-3fnrA:
3.2		 4drjB-3fnrA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ruegeria
pomeroyi) 		PF03480
(DctP) 		4 LEU A 230
PHE A 219
THR A   2
ASP A   1
 None
 0.97A 4drjB-3fxbA:
undetectable		 4drjB-3fxbA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz4 PUTATIVE ARSENATE
REDUCTASE

(Streptococcus
mutans) 		PF03960
(ArsC) 		4 LEU A  97
ASP A  26
TYR A  27
PHE A   4
 NA  A 201 (-4.6A)
None
None
None
 1.00A 4drjB-3fz4A:
undetectable		 4drjB-3fz4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1p PROTEIN PHNP

(Escherichia
coli) 		PF12706
(Lactamase_B_2) 		4 LEU A   7
SER A  41
TRP A 161
ASP A 187
 None
 1.10A 4drjB-3g1pA:
undetectable		 4drjB-3g1pA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1154
THR A 995
ASP A 998
PHE A1004
 None
 0.95A 4drjB-3hngA:
2.3		 4drjB-3hngA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htk E3 SUMO-PROTEIN
LIGASE MMS21

(Saccharomyces
cerevisiae) 		PF11789
(zf-Nse) 		4 LEU C 150
THR C 158
ASP C 156
TYR C 152
 None
 1.05A 4drjB-3htkC:
2.1		 4drjB-3htkC:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Thermococcus
kodakarensis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A 132
PHE A 356
ASP A 125
TYR A 127
 None
 1.01A 4drjB-3kdnA:
undetectable		 4drjB-3kdnA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lke ENOYL-COA HYDRATASE

(Bacillus
halodurans) 		PF00378
(ECH_1) 		4 LEU A  28
SER A  64
ASP A  20
TYR A  21
 None
 1.01A 4drjB-3lkeA:
undetectable		 4drjB-3lkeA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE

(Clostridioides
difficile) 		PF06050
(HGD-D) 		4 LEU A 200
SER A 207
THR A 247
ASP A 243
 None
 1.00A 4drjB-3o3oA:
undetectable		 4drjB-3o3oA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pic CIP2

(Trichoderma
reesei) 		no annotation 4 LEU A 296
THR A 269
ASP A 268
PHE A 429
 None
 1.04A 4drjB-3picA:
undetectable		 4drjB-3picA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poa PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8

(Mycobacterium
tuberculosis) 		PF00498
(FHA) 		4 LEU A  47
SER A  63
THR A  40
ASP A  39
 None
 1.10A 4drjB-3poaA:
undetectable		 4drjB-3poaA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pop GILR OXIDASE

(Streptomyces
griseoflavus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 LEU A 278
THR A 238
ASP A 236
PHE A 230
 None
 1.04A 4drjB-3popA:
undetectable		 4drjB-3popA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		4 THR A 197
ASP A 195
TYR A 193
PHE A 191
 None
 0.94A 4drjB-3t95A:
undetectable		 4drjB-3t95A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up6 HYPOTHETICAL PROTEIN
BACOVA_04078

(Bacteroides
ovatus) 		no annotation 4 SER A 273
PHE A 274
THR A 203
PHE A 183
 None
 1.05A 4drjB-3up6A:
undetectable		 4drjB-3up6A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		4 LEU A 166
SER A 170
TRP A 108
ASP A 150
 None
 0.92A 4drjB-3vilA:
undetectable		 4drjB-3vilA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpx LEUCINE
DEHYDROGENASE

(Sporosarcina
psychrophila) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A 251
SER A 228
THR A 175
ASP A 232
 None
 1.03A 4drjB-3vpxA:
undetectable		 4drjB-3vpxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wau 4-O-BETA-D-MANNOSYL-
D-GLUCOSE
PHOSPHORYLASE

(Bacteroides
fragilis) 		PF04041
(Glyco_hydro_130) 		4 LEU A  12
PHE A   4
ASP A  53
TYR A  52
 None
 1.07A 4drjB-3wauA:
undetectable		 4drjB-3wauA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 LEU A 326
SER A 323
ASP A 315
TYR A 316
 None
 1.03A 4drjB-4cnsA:
undetectable		 4drjB-4cnsA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 LEU A 326
SER A 323
ASP A 315
TYR A 316
 None
 1.05A 4drjB-4cntA:
undetectable		 4drjB-4cntA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epc N-ACETYLMURAMOYL-L-A
LANINE AMIDASE

(Staphylococcus
epidermidis) 		PF13457
(SH3_8) 		4 THR A 719
TRP A 763
ASP A 723
TYR A 722
 None
 0.89A 4drjB-4epcA:
undetectable		 4drjB-4epcA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fay MICROCOMPARTMENTS
PROTEIN

(Lactobacillus
reuteri) 		PF00936
(BMC) 		4 LEU A 112
PHE A 119
THR A  55
ASP A  22
 None
None
GOL  A 304 (-4.6A)
None
 0.81A 4drjB-4fayA:
undetectable		 4drjB-4fayA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		4 LEU A 212
SER A 211
THR A 229
TYR A 215
 None
 1.08A 4drjB-4fidA:
undetectable		 4drjB-4fidA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftd UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF15416
(DUF4623) 		4 LEU A 225
THR A 243
TRP A 241
TYR A 224
 None
 0.98A 4drjB-4ftdA:
undetectable		 4drjB-4ftdA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcn PROTEIN STI-1

(Caenorhabditis
elegans) 		PF13414
(TPR_11) 		4 LEU A  11
PHE A  41
THR A   2
ASP A   3
 None
 0.90A 4drjB-4gcnA:
2.1		 4drjB-4gcnA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 LEU A 901
ASP A 862
TYR A 865
PHE A 868
 None
 0.61A 4drjB-4j3bA:
undetectable		 4drjB-4j3bA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k37 ANAEROBIC
SULFATASE-MATURATING
ENZYME

(Clostridium
perfringens) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12) 		4 PHE A 240
ASP A 223
TYR A 226
PHE A 229
 None
GOL  A 511 (-4.8A)
None
None
 1.02A 4drjB-4k37A:
undetectable		 4drjB-4k37A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9a PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1393C

(Streptococcus
mutans) 		no annotation 4 LEU A 161
SER A 165
PHE A 169
TRP A 255
 None
 0.38A 4drjB-4l9aA:
undetectable		 4drjB-4l9aA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ouj HEMAGGLUTININ
COMPONENT HA33

(Clostridium
botulinum) 		PF14200
(RicinB_lectin_2) 		4 SER A  65
THR A  17
TRP A  50
TYR A  29
 None
 0.81A 4drjB-4oujA:
undetectable		 4drjB-4oujA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE

(Escherichia
coli) 		PF06315
(AceK) 		4 LEU A  53
ASP A  18
TYR A  21
PHE A  24
 None
 0.78A 4drjB-4p69A:
undetectable		 4drjB-4p69A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn9 COLLAGENASE

(Hathewaya
histolytica) 		PF00801
(PKD) 		4 THR A 730
TRP A 723
ASP A 724
PHE A 764
 None
 1.08A 4drjB-4tn9A:
undetectable		 4drjB-4tn9A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 LEU A  75
PHE A 377
ASP A 116
TYR A  74
 None
PE5  A 901 (-3.9A)
FAD  A 601 (-4.1A)
None
 0.92A 4drjB-4ud8A:
undetectable		 4drjB-4ud8A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
vulgaris) 		PF03480
(DctP) 		4 LEU A 116
SER A 245
THR A 125
ASP A 129
 None
PAF  A 401 ( 4.9A)
None
None
 1.07A 4drjB-4xeqA:
undetectable		 4drjB-4xeqA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz8 NUCLEOPROTEIN

(Thiafora
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 LEU A  82
SER A  84
PHE A 387
TYR A 459
 None
 0.81A 4drjB-4xz8A:
undetectable		 4drjB-4xz8A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yw5 NEURAMINIDASE C

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		4 THR A 333
TRP A 334
TYR A 326
PHE A 303
 None
 1.09A 4drjB-4yw5A:
undetectable		 4drjB-4yw5A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahv ENTH DOMAIN OF EPSIN
ENT1

(Saccharomyces
cerevisiae) 		PF01417
(ENTH) 		4 LEU E  42
SER E  46
ASP E  81
TYR E  82
 None
 1.06A 4drjB-5ahvE:
2.4		 4drjB-5ahvE:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxv MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 LEU A  81
THR A  95
TRP A  91
ASP A  99
 None
 0.96A 4drjB-5cxvA:
4.1		 4drjB-5cxvA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da0 NANOBODY
SULPHATE TRANSPORTER

(Deinococcus
geothermalis;
Lama glama) 		PF00916
(Sulfate_transp)
PF01740
(STAS)
PF07686
(V-set) 		4 PHE B  40
THR B 107
ASP A 455
TYR B 110
 None
 1.06A 4drjB-5da0B:
undetectable		 4drjB-5da0B:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Aspergillus
fumigatus) 		PF02358
(Trehalose_PPase) 		4 LEU A 211
SER A 238
PHE A 223
ASP A  24
 None
 0.98A 4drjB-5dxlA:
2.5		 4drjB-5dxlA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo6 COPROPORPHYRINOGEN
OXIDASE

(Acinetobacter
baumannii) 		PF01218
(Coprogen_oxidas) 		4 LEU A  16
THR A   7
ASP A   8
PHE A  15
 None
 1.08A 4drjB-5eo6A:
undetectable		 4drjB-5eo6A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		4 LEU A 141
SER A 251
THR A  74
ASP A  68
 None
 1.04A 4drjB-5ffnA:
undetectable		 4drjB-5ffnA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 LEU B 567
PHE B 612
THR B 587
ASP B 564
 None
 1.04A 4drjB-5gqrB:
undetectable		 4drjB-5gqrB:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		4 LEU A2031
SER A2035
THR A2098
PHE A2108
 None
 0.89A 4drjB-5h64A:
15.0		 4drjB-5h64A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		4 LEU A2031
SER A2035
TRP A2101
PHE A2108
 None
 0.83A 4drjB-5h64A:
15.0		 4drjB-5h64A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikj CRYPTIC LOCI
REGULATOR 2

(Schizosaccharomyces
pombe) 		PF10383
(Clr2)
PF16761
(Clr2_transil) 		4 LEU A 526
PHE A 291
ASP A 520
TYR A 522
 None
 1.03A 4drjB-5ikjA:
undetectable		 4drjB-5ikjA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqp 14-3-3 PROTEIN THETA

(Homo sapiens) 		PF00244
(14-3-3) 		4 PHE A 153
THR A 194
TYR A 178
PHE A 177
 None
 1.06A 4drjB-5iqpA:
3.6		 4drjB-5iqpA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqp GLUCOSIDASE 2
SUBUNIT BETA-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF12999
(PRKCSH-like) 		4 SER B  68
THR B  41
TYR B  35
PHE B  32
 None
 1.07A 4drjB-5jqpB:
undetectable		 4drjB-5jqpB:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc7 CEREBELLIN-1

(Homo sapiens) 		PF00386
(C1q) 		4 SER A 186
PHE A 185
THR A 103
PHE A 188
 None
 1.03A 4drjB-5kc7A:
undetectable		 4drjB-5kc7A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		4 SER A 186
PHE A 185
THR A 103
PHE A 188
 None
 1.02A 4drjB-5kcaA:
undetectable		 4drjB-5kcaA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		4 SER A 328
PHE A 327
THR A 245
PHE A 330
 None
 1.03A 4drjB-5kcaA:
undetectable		 4drjB-5kcaA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		4 SER A 470
PHE A 469
THR A 387
PHE A 472
 None
 1.06A 4drjB-5kcaA:
undetectable		 4drjB-5kcaA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwr CEREBELLIN-1

(Rattus
norvegicus) 		PF00386
(C1q) 		4 SER A 186
PHE A 185
THR A 103
PHE A 188
 None
 1.03A 4drjB-5kwrA:
undetectable		 4drjB-5kwrA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lad PUTATIVE GTP-BINDING
PROTEIN

(Thermotoga
maritima) 		PF01926
(MMR_HSR1) 		4 LEU A  62
SER A  51
ASP A  90
TYR A  11
 None
 1.07A 4drjB-5ladA:
undetectable		 4drjB-5ladA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A1716
SER A1720
THR A1740
ASP A1743
 None
 1.10A 4drjB-5nugA:
undetectable		 4drjB-5nugA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb CELL DIVISION
CONTROL PROTEIN 6

(Saccharomyces
cerevisiae) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 LEU 9 209
PHE 9 182
THR 9 241
PHE 9 256
 None
 0.94A 4drjB-5udb9:
undetectable		 4drjB-5udb9:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufv GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN

(Thermothelomyces
thermophila) 		PF03443
(Glyco_hydro_61) 		4 PHE A 109
THR A 120
TRP A 126
ASP A 119
 None
 0.99A 4drjB-5ufvA:
undetectable		 4drjB-5ufvA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3

(Saccharomyces
cerevisiae) 		PF08238
(Sel1) 		4 SER A 210
THR A 511
ASP A 514
TYR A 195
 None
 1.05A 4drjB-5v7vA:
3.0		 4drjB-5v7vA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 4 LEU A 362
PHE A 380
THR A 350
ASP A 354
 None
 0.92A 4drjB-5vhaA:
undetectable		 4drjB-5vhaA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsl KERATINASE

(Meiothermus
taiwanensis) 		no annotation 4 LEU A 131
SER A 224
THR A  74
ASP A  68
 None
 1.04A 4drjB-5wslA:
undetectable		 4drjB-5wslA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2v L-METHIONINE
GAMMA-LYASE

(Pseudomonas
putida) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A  67
SER A  63
THR A  37
TYR A  33
 None
 1.04A 4drjB-5x2vA:
undetectable		 4drjB-5x2vA:
13.71