SIMILAR PATTERNS OF AMINO ACIDS FOR 4DRH_D_RAPD201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ivg	CYANATE LYASE (Escherichia coli)	PF02560 (Cyanate_lyase)	5	ARG A 81 PHE A 126 THR A 145 ASP A 129 PHE A 42	None	1.46A	4drhE-2ivgA: undetectable	4drhE-2ivgA: 20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2o42	M11L PROTEIN (Myxoma virus)	PF11099 (M11L)	5	LEU A 5 SER A 3 THR A 22 ASP A 11 TYR A 10	None	1.39A	4drhE-2o42A: 0.0	4drhE-2o42A: 18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3e0j	DNA POLYMERASE SUBUNIT DELTA-3 (Homo sapiens)	PF09507 (CDC27)	5	LEU B 126 SER B 124 THR B 117 ASP B 118 TYR B 28	None	1.46A	4drhE-3e0jB: undetectable	4drhE-3e0jB: 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4l9a	PUTATIVE UNCHARACTERIZED PROTEIN SMU.1393C (Streptococcus mutans)	no annotation	5	LEU A 161 SER A 165 ARG A 166 PHE A 169 TRP A 255	None	0.63A	4drhE-4l9aA: undetectable	4drhE-4l9aA: 17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5t2o	I-ONUI_E-AG011377 (synthetic construct)	PF00961 (LAGLIDADG_1)	5	LEU A 49 ARG A 80 PHE A 45 THR A 16 ASP A 20	None	1.30A	4drhE-5t2oA: 3.0	4drhE-5t2oA: 15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6b6m	CYANATE HYDRATASE (Serratia proteamaculans)	no annotation	5	ARG A 81 PHE A 126 THR A 145 ASP A 129 PHE A 42	None	1.48A	4drhE-6b6mA: 0.0	4drhE-6b6mA: 20.00

[["4DRH_D_RAPD201_2","2ivg","Escherichia coli","CYANATE LYASE","PF02560(Cyanate_lyase)",5,"ARG A  81;PHE A 126;THR A 145;ASP A 129;PHE A  42","None","1.46A","4drhE-2ivgA:undetectable","4drhE-2ivgA:20.67"],["4DRH_D_RAPD201_2","2o42","Myxoma virus","M11L PROTEIN","PF11099(M11L)",5,"LEU A   5;SER A   3;THR A  22;ASP A  11;TYR A  10","None","1.39A","4drhE-2o42A:0.0","4drhE-2o42A:18.92"],["4DRH_D_RAPD201_2","3e0j","Homo sapiens","DNA POLYMERASE SUBUNIT DELTA-3","PF09507(CDC27)",5,"LEU B 126;SER B 124;THR B 117;ASP B 118;TYR B  28","None","1.46A","4drhE-3e0jB:undetectable","4drhE-3e0jB:20.83"],["4DRH_D_RAPD201_2","4l9a","Streptococcus mutans","PUTATIVE UNCHARACTERIZED PROTEIN SMU.1393C","no annotation",5,"LEU A 161;SER A 165;ARG A 166;PHE A 169;TRP A 255","None","0.63A","4drhE-4l9aA:undetectable","4drhE-4l9aA:17.81"],["4DRH_D_RAPD201_2","5t2o","synthetic construct","I-ONUI_E-AG011377","PF00961(LAGLIDADG_1)",5,"LEU A  49;ARG A  80;PHE A  45;THR A  16;ASP A  20","None","1.30A","4drhE-5t2oA:3.0","4drhE-5t2oA:15.75"],["4DRH_D_RAPD201_2","6b6m","Serratia proteamaculans","CYANATE HYDRATASE","no annotation",5,"ARG A  81;PHE A 126;THR A 145;ASP A 129;PHE A  42","None","1.48A","4drhE-6b6mA:0.0","4drhE-6b6mA:20.00"]]