SIMILAR PATTERNS OF AMINO ACIDS FOR 4DRH_A_RAPA201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivg CYANATE LYASE

(Escherichia
coli) 		PF02560
(Cyanate_lyase) 		5 ARG A  81
PHE A 126
THR A 145
ASP A 129
PHE A  42
 None
 1.44A 4drhB-2ivgA:
0.5		 4drhB-2ivgA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6d PUTATIVE
OXIDOREDUCTASE

(Pseudomonas
putida) 		PF03446
(NAD_binding_2) 		5 LEU A 157
SER A 141
THR A 101
ASP A  99
PHE A 150
 None
 1.29A 4drhB-3l6dA:
0.0		 4drhB-3l6dA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9a PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1393C

(Streptococcus
mutans) 		no annotation 5 LEU A 161
SER A 165
ARG A 166
PHE A 169
TRP A 255
 None
 0.63A 4drhB-4l9aA:
undetectable		 4drhB-4l9aA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6m CYANATE HYDRATASE

(Serratia
proteamaculans) 		no annotation 5 ARG A  81
PHE A 126
THR A 145
ASP A 129
PHE A  42
 None
 1.47A 4drhB-6b6mA:
0.0		 4drhB-6b6mA:
20.00