SIMILAR PATTERNS OF AMINO ACIDS FOR 4DR5_A_SRYA1860

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2r PROTEIN
(TRYPTOPHANYL TRNA
SYNTHETASE)

(Geobacillus
stearothermophilus) 		PF00579
(tRNA-synt_1b) 		3 LYS A 201
PRO A 200
LYS A 215
 None
 1.15A 4dr5L-1d2rA:
0.0		 4dr5L-1d2rA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1je5 HELIX-DESTABILIZING
PROTEIN

(Escherichia
virus T7) 		no annotation 3 LYS A 169
PRO A  95
LYS A 109
 None
 1.48A 4dr5L-1je5A:
1.9		 4dr5L-1je5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7p PHOSPHOSERINE
PHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF12710
(HAD) 		3 LYS A 187
PRO A 188
LYS A  40
 None
 1.46A 4dr5L-1l7pA:
0.0		 4dr5L-1l7pA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		3 LYS A  74
PRO A  77
LYS A 115
 None
 1.42A 4dr5L-1lw3A:
0.0		 4dr5L-1lw3A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE

(Thermotoga
maritima) 		PF02547
(Queuosine_synth) 		3 LYS A  76
PRO A  97
LYS A  72
 None
 1.19A 4dr5L-1vkyA:
0.0		 4dr5L-1vkyA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		3 LYS A 362
PRO A 385
LYS A 355
 None
 1.47A 4dr5L-1wacA:
0.0		 4dr5L-1wacA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 LYS A 353
PRO A 355
LYS A 311
 None
 0.89A 4dr5L-1we5A:
0.0		 4dr5L-1we5A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bol SMALL HEAT SHOCK
PROTEIN

(Taenia saginata) 		PF00011
(HSP20) 		3 LYS A 251
PRO A 207
LYS A 196
 None
 1.46A 4dr5L-2bolA:
0.0		 4dr5L-2bolA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czv RIBONUCLEASE P
PROTEIN COMPONENT 2

(Pyrococcus
horikoshii) 		PF01900
(RNase_P_Rpp14) 		3 LYS C  31
PRO C  63
LYS C  60
 None
 1.49A 4dr5L-2czvC:
0.0		 4dr5L-2czvC:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i00 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 LYS A 141
PRO A 325
LYS A 110
 None
 1.28A 4dr5L-2i00A:
undetectable		 4dr5L-2i00A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i76 HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF10728
(DUF2520) 		3 LYS A  52
PRO A  54
LYS A  46
 None
 1.36A 4dr5L-2i76A:
undetectable		 4dr5L-2i76A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvp D-ALANINE-D-ALANINE
LIGASE

(Helicobacter
pylori) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 LYS A 171
PRO A 172
LYS A 130
 None
 1.44A 4dr5L-2pvpA:
undetectable		 4dr5L-2pvpA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adc L-SERYL-TRNA(SEC)
KINASE

(Methanocaldococcus
jannaschii) 		PF08433
(KTI12) 		3 LYS A  95
PRO A 171
LYS A  -1
 None
 1.19A 4dr5L-3adcA:
undetectable		 4dr5L-3adcA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4r UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF06254
(YdaT_toxin) 		3 LYS A  72
PRO A  40
LYS A  57
 None
 1.49A 4dr5L-3c4rA:
undetectable		 4dr5L-3c4rA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwu MACROPHAGE MIGRATION
INHIBITORY
FACTOR-LIKE PROTEIN

(Leishmania
major) 		PF01187
(MIF) 		3 LYS A  33
PRO A  34
LYS A   0
 None
 1.40A 4dr5L-3fwuA:
undetectable		 4dr5L-3fwuA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9j MEMBER OF DUF4221
FAMILY

(Bacteroides
vulgatus) 		PF13970
(DUF4221) 		3 LYS A 178
PRO A 179
LYS A 182
 None
 1.37A 4dr5L-3s9jA:
undetectable		 4dr5L-3s9jA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqj HEMAGGLUTININ

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		3 LYS A 304
PRO A 305
LYS A  33
 None
 1.37A 4dr5L-4fqjA:
undetectable		 4dr5L-4fqjA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkv LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		3 LYS A 304
PRO A 302
LYS A 340
 None
 1.13A 4dr5L-4pkvA:
undetectable		 4dr5L-4pkvA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 LYS A  45
PRO A  46
LYS A  80
 None
 1.42A 4dr5L-4qk3A:
undetectable		 4dr5L-4qk3A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd2 ENDO-1,4-D-GLUCANASE

(Aliivibrio
fischeri) 		PF01270
(Glyco_hydro_8) 		3 LYS A 238
PRO A 292
LYS A 313
 None
 1.49A 4dr5L-5cd2A:
undetectable		 4dr5L-5cd2A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE

(Bacillus
subtilis) 		PF09819
(ABC_cobalt) 		3 LYS A  62
PRO A  63
LYS A   3
 None
MPG  A 202 ( 4.3A)
None
 1.36A 4dr5L-5edlA:
undetectable		 4dr5L-5edlA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmf TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT BETA,
TFG2

(Saccharomyces
cerevisiae) 		PF02270
(TFIIF_beta) 		3 LYS V 342
PRO V 344
LYS V 348
 None
 1.45A 4dr5L-5fmfV:
undetectable		 4dr5L-5fmfV:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 LYS A 789
PRO A 870
LYS A 459
 None
 1.49A 4dr5L-5hy7A:
undetectable		 4dr5L-5hy7A:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msn DCC1 PROTEIN

(Saccharomyces
cerevisiae) 		PF09724
(Dcc1) 		3 LYS A 326
PRO A 325
LYS A 364
 None
 1.41A 4dr5L-5msnA:
undetectable		 4dr5L-5msnA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oes GLUTATHIONE
SYNTHETASE

(Solanum
tuberosum) 		no annotation 3 LYS A 372
PRO A 373
LYS A 318
 ADP  A 501 (-2.9A)
None
ADP  A 501 (-3.9A)
 1.47A 4dr5L-5oesA:
undetectable		 4dr5L-5oesA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 3 LYS A  66
PRO A  69
LYS A 167
 None
 1.36A 4dr5L-5opqA:
undetectable		 4dr5L-5opqA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 3 LYS A 180
PRO A 244
LYS A 296
 None
 1.31A 4dr5L-6a8mA:
undetectable		 4dr5L-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1

(Caenorhabditis
elegans) 		no annotation 3 LYS A 227
PRO A 225
LYS A 332
 None
 1.19A 4dr5L-6b5dA:
undetectable		 4dr5L-6b5dA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT C'
V-TYPE PROTON ATPASE
SUBUNIT D

(Saccharomyces
cerevisiae) 		no annotation 3 LYS B   2
PRO B 203
LYS D  40
 None
 0.97A 4dr5L-6c6lB:
undetectable		 4dr5L-6c6lB:
19.71