SIMILAR PATTERNS OF AMINO ACIDS FOR 4DPR_A_X8ZA702_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		5 TYR A 168
GLY A 211
GLU A 173
GLU A 145
LYS A   1
 None
 1.48A 4dprA-1fohA:
undetectable		 4dprA-1fohA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpe DSBD-ALPHA

(Escherichia
coli) 		PF11412
(DsbC) 		5 TYR A  71
GLY A  72
GLU A  69
TYR A  42
TYR A  40
 None
 1.16A 4dprA-1jpeA:
undetectable		 4dprA-1jpeA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3k CREATININASE

(Pseudomonas
putida) 		PF02633
(Creatininase) 		5 TYR A 121
GLY A  79
HIS A  36
GLU A  34
GLU A 183
 None
None
ZN  A 301 (-3.3A)
ZN  A 300 (-2.5A)
ZN  A 301 (-2.1A)
 1.45A 4dprA-1q3kA:
undetectable		 4dprA-1q3kA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus) 		PF01432
(Peptidase_M3) 		5 GLY A 327
HIS A 356
GLU A 384
TYR A 486
TYR A 490
 None
ZN  A 601 (-3.3A)
ZN  A 601 (-2.2A)
None
UNL  A 605 ( 4.5A)
 0.98A 4dprA-2h1nA:
2.3		 4dprA-2h1nA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus) 		PF01432
(Peptidase_M3) 		5 HIS A 356
GLU A 357
GLU A 384
TYR A 486
TYR A 490
 ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-2.2A)
None
UNL  A 605 ( 4.5A)
 0.92A 4dprA-2h1nA:
2.3		 4dprA-2h1nA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 GLY A 313
HIS A 340
GLU A 341
GLU A 363
TYR A 429
 None
ZN  A1673 (-3.3A)
None
ZN  A1673 (-2.2A)
None
 0.89A 4dprA-2xpzA:
43.1		 4dprA-2xpzA:
40.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 GLY A 314
HIS A 340
GLU A 341
GLU A 363
TYR A 429
 None
ZN  A1673 (-3.3A)
None
ZN  A1673 (-2.2A)
None
 1.10A 4dprA-2xpzA:
43.1		 4dprA-2xpzA:
40.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 GLY A 317
HIS A 353
GLU A 354
GLU A 376
TYR A 438
 BES  A1950 (-3.7A)
ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.36A 4dprA-2yd0A:
32.3		 4dprA-2yd0A:
21.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		7 GLY A 297
HIS A 324
GLU A 325
GLU A 347
TYR A 410
ARG A 584
LYS A 586
 None
ZN  A 701 (-4.1A)
ZN  A 701 ( 4.6A)
ZN  A 701 (-3.4A)
None
None
None
 0.53A 4dprA-3ciaA:
47.2		 4dprA-3ciaA:
37.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		5 HIS A 265
GLU A 266
GLU A 295
TYR A 416
TYR A 420
 ZN  A 502 ( 3.4A)
PO4  A 503 (-3.0A)
ZN  A 502 ( 2.2A)
None
PO4  A 503 (-4.2A)
 0.94A 4dprA-3hq2A:
6.9		 4dprA-3hq2A:
23.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u9w LEUKOTRIENE A-4
HYDROLASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		9 TYR A1267
GLY A1268
HIS A1295
GLU A1296
GLU A1318
TYR A1378
TYR A1383
ARG A1563
LYS A1565
 28P  A7001 (-3.6A)
None
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.3A)
28P  A7001 (-4.6A)
None
None
 0.36A 4dprA-3u9wA:
61.2		 4dprA-3u9wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u9w LEUKOTRIENE A-4
HYDROLASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 TYR A1267
GLY A1269
GLU A1271
TYR A1378
TYR A1383
 28P  A7001 (-3.6A)
None
28P  A7001 (-3.6A)
28P  A7001 (-4.3A)
28P  A7001 (-4.6A)
 0.99A 4dprA-3u9wA:
61.2		 4dprA-3u9wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u9w LEUKOTRIENE A-4
HYDROLASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		6 TYR A1267
GLY A1269
HIS A1295
GLU A1318
TYR A1378
TYR A1383
 28P  A7001 (-3.6A)
None
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.3A)
28P  A7001 (-4.6A)
 0.89A 4dprA-3u9wA:
61.2		 4dprA-3u9wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u9w LEUKOTRIENE A-4
HYDROLASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 TYR A1267
GLY A1269
HIS A1299
GLU A1271
TYR A1378
 28P  A7001 (-3.6A)
None
ZN  A2001 ( 3.2A)
28P  A7001 (-3.6A)
28P  A7001 (-4.3A)
 1.08A 4dprA-3u9wA:
61.2		 4dprA-3u9wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u9w LEUKOTRIENE A-4
HYDROLASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 TYR A1267
GLY A1269
HIS A1299
GLU A1318
TYR A1378
 28P  A7001 (-3.6A)
None
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.3A)
 1.18A 4dprA-3u9wA:
61.2		 4dprA-3u9wA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ar9 COLLAGENASE COLT

(Clostridium
tetani) 		PF01752
(Peptidase_M9) 		5 HIS A 465
GLU A 466
GLU A 499
TYR A 541
TYR A 548
 ZN  A1731 (-3.3A)
ZN  A1731 (-3.9A)
ZN  A1731 (-2.6A)
None
None
 1.45A 4dprA-4ar9A:
7.7		 4dprA-4ar9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN

(Idiomarina
loihiensis) 		PF05299
(Peptidase_M61)
PF13180
(PDZ_2) 		5 GLY A 235
HIS A 273
GLU A 274
GLU A 307
TYR A 377
 None
ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.68A 4dprA-4fgmA:
20.1		 4dprA-4fgmA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 GLY A 352
HIS A 388
GLU A 389
GLU A 411
TYR A 477
 None
 0.35A 4dprA-4fysA:
21.6		 4dprA-4fysA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 HIS A 388
GLU A 389
GLU A 411
TYR A 477
ARG A 381
 None
 1.36A 4dprA-4fysA:
21.6		 4dprA-4fysA:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gaa MGC78867 PROTEIN

(Xenopus laevis) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		8 TYR A 264
GLY A 265
HIS A 292
GLU A 293
GLU A 315
TYR A 380
ARG A 560
LYS A 562
 BES  A 702 (-3.3A)
BES  A 702 (-3.2A)
ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
BES  A 702 (-4.0A)
BES  A 702 ( 4.7A)
 0.54A 4dprA-4gaaA:
55.9		 4dprA-4gaaA:
67.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gaa MGC78867 PROTEIN

(Xenopus laevis) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 TYR A 264
GLY A 266
HIS A 292
GLU A 315
TYR A 380
 BES  A 702 (-3.3A)
BES  A 702 (-4.3A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 1.03A 4dprA-4gaaA:
55.9		 4dprA-4gaaA:
67.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 GLY A 460
HIS A 496
GLU A 497
GLU A 519
TYR A 580
 None
ZN  A1102 ( 3.2A)
ARG  A1101 (-2.5A)
ZN  A1102 ( 2.1A)
ARG  A1101 (-4.5A)
 0.31A 4dprA-4j3bA:
22.4		 4dprA-4j3bA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 GLY A 357
HIS A 393
GLU A 394
GLU A 416
TYR A 479
 BES  A1017 (-3.0A)
ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.45A 4dprA-4kxbA:
31.4		 4dprA-4kxbA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 GLY A 257
HIS A 293
GLU A 294
GLU A 316
TYR A 377
 37B  A 901 (-3.4A)
37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.35A 4dprA-4qmeA:
23.2		 4dprA-4qmeA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 GLY A 330
HIS A 366
GLU A 367
GLU A 389
TYR A 452
 None
ZN  A1001 (-3.3A)
ZN  A1001 ( 4.3A)
ZN  A1001 (-2.4A)
None
 0.37A 4dprA-4wz9A:
23.2		 4dprA-4wz9A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 GLY A 261
HIS A 297
GLU A 298
GLU A 320
TYR A 381
 GOL  A 909 (-3.7A)
ZN  A 901 ( 3.2A)
ARG  A 902 (-2.8A)
ZN  A 901 ( 2.1A)
GOL  A 910 ( 3.5A)
 0.35A 4dprA-4xmvA:
30.7		 4dprA-4xmvA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 GLY A 334
HIS A 370
GLU A 371
GLU A 393
TYR A 455
 6GA  A1015 (-3.7A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
 0.39A 4dprA-5j6sA:
31.8		 4dprA-5j6sA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 5 TYR A 307
GLY A 308
HIS A 310
GLU A 245
ARG A 350
 None
None
SO4  A 501 (-4.0A)
None
None
 1.50A 4dprA-5nijA:
undetectable		 4dprA-5nijA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7e COLH PROTEIN

(Hathewaya
histolytica) 		no annotation 5 GLY A 425
HIS A 455
GLU A 456
GLU A 487
TYR A 538
 None
ZN  A 801 ( 3.3A)
9NB  A 803 (-3.5A)
ZN  A 801 ( 2.3A)
None
 0.30A 4dprA-5o7eA:
8.6		 4dprA-5o7eA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 5 GLY A 347
HIS A 383
GLU A 384
GLU A 406
TYR A 472
 SO4  A1027 (-3.1A)
ZN  A1035 (-3.2A)
ILE  A1024 ( 4.1A)
ZN  A1035 ( 2.2A)
SO4  A1032 ( 4.1A)
 0.68A 4dprA-6bv2A:
25.0		 4dprA-6bv2A:
8.29