SIMILAR PATTERNS OF AMINO ACIDS FOR 4DM8_B_REAB1501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		5 LEU A  99
ALA A 100
LEU A  20
ILE A  33
GLY A  19
 None
 1.10A 4dm8B-1ao0A:
0.0		 4dm8B-1ao0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxn PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN)

(Cupriavidus
necator) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 PHE A 111
LEU A  40
ILE A 124
PHE A  43
GLY A 310
 None
 0.92A 4dm8B-1bxnA:
0.0		 4dm8B-1bxnA:
19.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 PHE A 201
PHE A 230
LEU A 233
ALA A 234
LEU A 268
LEU A 271
ARG A 278
SER A 289
PHE A 304
GLY A 393
LEU A 400
 961  A 450 (-4.5A)
961  A 450 (-3.9A)
961  A 450 ( 4.0A)
961  A 450 (-3.1A)
961  A 450 ( 4.9A)
961  A 450 (-3.6A)
961  A 450 (-3.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
961  A 450 ( 4.0A)
None
 0.53A 4dm8B-1exxA:
38.6		 4dm8B-1exxA:
79.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH

(Escherichia
coli) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		5 LEU A  14
LEU A  36
LEU A  39
ILE A  40
LEU A  58
 None
 1.06A 4dm8B-1gz0A:
undetectable		 4dm8B-1gz0A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwa RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Galdieria
partita) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 PHE A 108
LEU A 105
ILE A 101
ARG A 139
GLY A  59
 None
 1.12A 4dm8B-1iwaA:
0.0		 4dm8B-1iwaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		5 LEU A  89
ALA A  90
LEU A  17
ILE A  18
GLY A 166
 None
 0.88A 4dm8B-1j0aA:
undetectable		 4dm8B-1j0aA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jct GLUCARATE
DEHYDRATASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		5 PHE A 351
PHE A  36
LEU A 378
SER A 340
LEU A 413
 None
 1.12A 4dm8B-1jctA:
0.0		 4dm8B-1jctA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE

(Thermus
thermophilus) 		PF00764
(Arginosuc_synth) 		5 PHE A 220
ALA A 337
SER A 287
GLY A 274
LEU A 238
 None
 0.84A 4dm8B-1kh2A:
0.0		 4dm8B-1kh2A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpc DIANTHIN 30

(Dianthus
caryophyllus) 		PF00161
(RIP) 		6 LEU A 168
ALA A 171
LEU A   8
LEU A 147
ILE A 148
GLY A  58
 None
 1.40A 4dm8B-1lpcA:
0.0		 4dm8B-1lpcA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpc DIANTHIN 30

(Dianthus
caryophyllus) 		PF00161
(RIP) 		6 PHE A 167
ALA A 171
LEU A   8
LEU A 147
ILE A 148
GLY A  58
 None
 1.19A 4dm8B-1lpcA:
0.0		 4dm8B-1lpcA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 LEU B 649
ALA B 650
LEU B 205
ILE B 207
LEU B 161
 None
 1.03A 4dm8B-1m2vB:
undetectable		 4dm8B-1m2vB:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		5 PHE B 374
ALA B 399
LEU B 388
LEU B 389
ILE B 390
 None
 0.98A 4dm8B-1mioB:
undetectable		 4dm8B-1mioB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n97 CYP175A1

(Thermus
thermophilus) 		PF00067
(p450) 		5 LEU A  43
ALA A  44
LEU A 279
LEU A 286
LEU A  56
 None
 1.06A 4dm8B-1n97A:
undetectable		 4dm8B-1n97A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		5 LEU A  32
ALA A  31
LEU A  52
LEU A  53
GLY A  21
 None
 1.12A 4dm8B-1o2dA:
undetectable		 4dm8B-1o2dA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Haemophilus
influenzae) 		PF00793
(DAHP_synth_1) 		5 PHE A 184
LEU A 224
ALA A 225
LEU A  21
LEU A 236
 None
 0.91A 4dm8B-1o60A:
undetectable		 4dm8B-1o60A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A  14
ALA A  15
LEU A  98
ILE A  60
GLY A  62
 None
 1.09A 4dm8B-1o8cA:
undetectable		 4dm8B-1o8cA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 209
ALA A 212
ILE A 183
SER A 205
GLY A 160
 None
None
NAD  A 400 (-3.8A)
None
None
 1.08A 4dm8B-1pl8A:
undetectable		 4dm8B-1pl8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0l 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Zymomonas
mobilis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 ALA A  54
LEU A  21
SER A  75
GLY A  17
LEU A  10
 None
 1.09A 4dm8B-1r0lA:
undetectable		 4dm8B-1r0lA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 LEU A 244
LEU A 373
LEU A 396
SER A 294
GLY A 355
 None
 0.99A 4dm8B-1rf5A:
undetectable		 4dm8B-1rf5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		5 PHE A 305
ILE A 192
SER A 218
PHE A 322
GLY A 263
 None
 1.07A 4dm8B-1smrA:
undetectable		 4dm8B-1smrA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF13177
(DNA_pol3_delta2) 		5 LEU E 303
LEU E 300
ILE E 299
SER E 333
LEU E 279
 None
 1.08A 4dm8B-1sxjE:
undetectable		 4dm8B-1sxjE:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 PHE A 405
ALA A 442
LEU A 446
ARG A  33
PHE A 401
 None
 0.85A 4dm8B-1v8bA:
undetectable		 4dm8B-1v8bA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE

(Caenorhabditis
elegans) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		5 LEU A 293
LEU A 297
ILE A 298
ARG A 303
GLY A 309
 None
 1.07A 4dm8B-1vkoA:
undetectable		 4dm8B-1vkoA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsj RIBONUCLEASE HI

(Escherichia
coli) 		PF00075
(RNase_H) 		5 ALA A  58
LEU A  26
ILE A  25
ARG A  31
GLY A  23
 None
 1.10A 4dm8B-1wsjA:
undetectable		 4dm8B-1wsjA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuu GALACTOKINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 LEU A 295
ALA A 292
LEU A 200
ILE A 201
GLY A  50
 None
 1.04A 4dm8B-1wuuA:
undetectable		 4dm8B-1wuuA:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xap RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 PHE A 192
LEU A 224
LEU A 259
ILE A 263
ARG A 269
SER A 280
PHE A 295
LEU A 391
 None
TTB  A   1 (-4.4A)
TTB  A   1 ( 4.9A)
TTB  A   1 ( 4.9A)
TTB  A   1 (-3.3A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.1A)
None
 0.78A 4dm8B-1xapA:
38.2		 4dm8B-1xapA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xap RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 PHE A 221
LEU A 224
ALA A 225
LEU A 259
LEU A 262
ILE A 263
ARG A 269
SER A 280
PHE A 295
GLY A 384
LEU A 391
 TTB  A   1 (-4.7A)
TTB  A   1 (-4.4A)
TTB  A   1 (-4.0A)
TTB  A   1 ( 4.9A)
TTB  A   1 (-3.9A)
TTB  A   1 ( 4.9A)
TTB  A   1 (-3.3A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.1A)
TTB  A   1 ( 4.0A)
None
 0.65A 4dm8B-1xapA:
38.2		 4dm8B-1xapA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xdk RETINOIC ACID
RECEPTOR, BETA

(Mus musculus) 		PF00104
(Hormone_recep) 		12 PHE B 192
PHE B 221
LEU B 224
ALA B 225
LEU B 259
LEU B 262
ILE B 263
ARG B 269
SER B 280
PHE B 295
GLY B 384
LEU B 391
 9CR  B 600 (-4.8A)
9CR  B 600 ( 4.7A)
9CR  B 600 ( 4.0A)
9CR  B 600 (-3.8A)
None
9CR  B 600 (-3.9A)
9CR  B 600 (-4.0A)
9CR  B 600 (-3.8A)
9CR  B 600 (-3.0A)
9CR  B 600 (-3.9A)
9CR  B 600 ( 4.6A)
None
 0.51A 4dm8B-1xdkB:
38.2		 4dm8B-1xdkB:
92.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 ALA B 301
LEU B 298
SER B 322
PHE B 213
GLY B 209
 None
 1.02A 4dm8B-2amcB:
undetectable		 4dm8B-2amcB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00266
(Aminotran_5) 		5 PHE A 218
ALA A 222
LEU A  81
ILE A  80
PHE A  75
 None
 1.13A 4dm8B-2bkwA:
undetectable		 4dm8B-2bkwA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0y PROCATHEPSIN S

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 PHE A 174
LEU A 133
ALA A 132
LEU A 266
GLY A 236
 None
 1.10A 4dm8B-2c0yA:
undetectable		 4dm8B-2c0yA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE

(Oryza sativa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 PHE A 143
ALA A 392
LEU A 408
PHE A  98
GLY A 407
 None
 1.11A 4dm8B-2cvoA:
undetectable		 4dm8B-2cvoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 LEU A 161
ALA A 162
LEU A 223
LEU A 219
ILE A 222
 None
 1.09A 4dm8B-2dc0A:
undetectable		 4dm8B-2dc0A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh3 TRANSCRIPTIONAL
REGULATOR

(Aquifex
aeolicus) 		PF00440
(TetR_N) 		5 PHE A  65
ALA A 115
LEU A 142
LEU A 139
ILE A 138
 None
 0.89A 4dm8B-2eh3A:
undetectable		 4dm8B-2eh3A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		5 ALA A  90
LEU A 395
ILE A 396
GLY A 373
LEU A 434
 None
None
None
HEM  A 600 ( 4.2A)
None
 1.08A 4dm8B-2f9qA:
undetectable		 4dm8B-2f9qA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME

(Agrobacterium
tumefaciens) 		PF00206
(Lyase_1) 		5 LEU A 341
ALA A 338
LEU A 131
LEU A 134
ILE A 135
 None
 0.90A 4dm8B-2felA:
undetectable		 4dm8B-2felA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm8 CELL INVASION
PROTEIN SIPA

(Salmonella
enterica) 		PF09052
(SipA) 		5 LEU C 103
ALA C 102
LEU C 253
LEU C 252
LEU C 229
 None
 1.07A 4dm8B-2fm8C:
undetectable		 4dm8B-2fm8C:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6b RAS-RELATED PROTEIN
RAB-26

(Homo sapiens) 		PF00071
(Ras) 		5 ALA A 217
LEU A 143
LEU A 175
ARG A 189
GLY A  75
 None
None
None
None
GNP  A 302 (-3.3A)
 1.02A 4dm8B-2g6bA:
undetectable		 4dm8B-2g6bA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6b RAS-RELATED PROTEIN
RAB-26

(Homo sapiens) 		PF00071
(Ras) 		5 LEU A 216
ALA A 217
LEU A 143
LEU A 175
GLY A  75
 None
None
None
None
GNP  A 302 (-3.3A)
 0.69A 4dm8B-2g6bA:
undetectable		 4dm8B-2g6bA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		6 LEU A  97
LEU A 100
ILE A 101
ARG A 107
GLY A  67
LEU A 131
 None
 1.33A 4dm8B-2hnhA:
undetectable		 4dm8B-2hnhA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imh HYPOTHETICAL PROTEIN
UNP Q5LQD5_SILPO

(Ruegeria
pomeroyi) 		PF06267
(DUF1028) 		5 LEU A 191
LEU A 145
ILE A 188
SER A 136
LEU A  31
 None
 1.08A 4dm8B-2imhA:
undetectable		 4dm8B-2imhA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o9r BETA-GLUCOSIDASE B

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		5 LEU A 111
ALA A 112
LEU A  76
LEU A 114
ILE A 115
 None
 1.02A 4dm8B-2o9rA:
undetectable		 4dm8B-2o9rA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1

(Rattus
norvegicus) 		PF12796
(Ank_2) 		5 PHE A 189
LEU A 175
ALA A 174
LEU A 216
GLY A 168
 PHE  A 189 ( 1.3A)
LEU  A 175 ( 0.5A)
ALA  A 174 ( 0.0A)
LEU  A 216 ( 0.5A)
GLY  A 168 ( 0.0A)
 1.03A 4dm8B-2pnnA:
undetectable		 4dm8B-2pnnA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r14 MORPHINONE REDUCTASE

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		6 LEU A 103
ALA A 102
LEU A  17
LEU A  57
GLY A 301
LEU A 269
 None
 1.32A 4dm8B-2r14A:
undetectable		 4dm8B-2r14A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 PHE A  27
ALA A  26
LEU A 109
LEU A  22
ILE A  19
 None
 1.11A 4dm8B-2rb9A:
undetectable		 4dm8B-2rb9A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 LEU A 762
ALA A 763
LEU A 740
PHE A 817
GLY A 778
 GOL  A1924 (-4.3A)
None
None
None
None
 1.04A 4dm8B-2wanA:
undetectable		 4dm8B-2wanA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wm4 PUTATIVE CYTOCHROME
P450 124

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 PHE A 191
LEU A 171
LEU A 423
ILE A 420
LEU A 283
 None
 1.00A 4dm8B-2wm4A:
undetectable		 4dm8B-2wm4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD) 		5 ALA A1077
LEU A1091
LEU A1098
GLY A1127
LEU A1130
 None
 1.11A 4dm8B-2ya1A:
undetectable		 4dm8B-2ya1A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ALA A 622
LEU A 636
LEU A 643
GLY A 672
LEU A 675
 None
 1.11A 4dm8B-2ya2A:
undetectable		 4dm8B-2ya2A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b74 UNCHARACTERIZED
PROTEIN YKL091C

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 LEU A  49
LEU A  25
LEU A  33
GLY A  23
LEU A 171
 None
 1.12A 4dm8B-3b74A:
undetectable		 4dm8B-3b74A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbl REGULATORY PROTEIN
OF LACI FAMILY

(Chloroflexus
aggregans) 		PF13377
(Peripla_BP_3) 		5 LEU A 271
ALA A 266
LEU A 295
GLY A 281
LEU A 190
 None
None
EDO  A 501 (-4.3A)
None
None
 1.03A 4dm8B-3bblA:
undetectable		 4dm8B-3bblA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfx UPF0100 PROTEIN
MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		5 LEU A  95
LEU A  58
SER A  81
PHE A 118
GLY A 320
 None
 0.85A 4dm8B-3cfxA:
undetectable		 4dm8B-3cfxA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlc PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE

(Methanococcus
maripaludis) 		PF08241
(Methyltransf_11) 		5 PHE A  66
ALA A  59
SER A  64
GLY A 148
LEU A 154
 None
 0.92A 4dm8B-3dlcA:
undetectable		 4dm8B-3dlcA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqv CULLIN-5

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		6 PHE C1450
LEU C1408
ALA C1409
LEU C1416
SER C1402
LEU C1493
 None
 1.50A 4dm8B-3dqvC:
undetectable		 4dm8B-3dqvC:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4

(Rattus
norvegicus) 		PF13848
(Thioredoxin_6) 		5 ALA A 391
LEU A 353
ILE A 383
PHE A 334
GLY A 308
 None
 1.04A 4dm8B-3ec3A:
undetectable		 4dm8B-3ec3A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epf PROTEIN VP1
PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		5 PHE 1 208
LEU 2 132
ALA 2 133
ARG 1 272
GLY 1 289
 None
 1.11A 4dm8B-3epf1:
undetectable		 4dm8B-3epf1:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbk REGULATOR OF
G-PROTEIN SIGNALING
3

(Homo sapiens) 		PF00168
(C2) 		5 PHE A  97
LEU A 154
ILE A 131
ARG A 121
GLY A  35
 None
 1.10A 4dm8B-3fbkA:
undetectable		 4dm8B-3fbkA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg0 KLEBSIELLA
PNEUMONIAE BLRP1

(Klebsiella
pneumoniae) 		PF00563
(EAL)
PF04940
(BLUF) 		5 LEU A 128
LEU A  95
LEU A  41
PHE A  87
LEU A 110
 None
 1.13A 4dm8B-3gg0A:
undetectable		 4dm8B-3gg0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi7 SECRETED PROTEIN OF
UNKNOWN FUNCTION
DUF1311

(Pseudomonas
putida) 		PF07007
(LprI) 		5 ALA A  83
LEU A  62
ARG A  91
SER A  88
GLY A 132
 None
None
SO4  A 203 (-2.9A)
SO4  A 203 (-3.9A)
None
 1.07A 4dm8B-3gi7A:
undetectable		 4dm8B-3gi7A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2s PUTATIVE NADH-FLAVIN
REDUCTASE

(Lactobacillus
paracasei) 		PF13460
(NAD_binding_10) 		5 PHE A 102
ALA A 100
LEU A  92
LEU A  93
ARG A 207
 None
 1.11A 4dm8B-3h2sA:
undetectable		 4dm8B-3h2sA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		5 ALA A 124
LEU A  81
LEU A  88
ILE A  83
GLY A 143
 None
 1.12A 4dm8B-3hjrA:
undetectable		 4dm8B-3hjrA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ALA A 202
LEU A 282
ILE A 283
SER A 210
GLY A 222
 None
None
EDO  A  23 ( 4.7A)
None
None
 1.06A 4dm8B-3ihvA:
undetectable		 4dm8B-3ihvA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6x SOLUTE-BINDING
PROTEIN MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		5 LEU A  95
LEU A  58
SER A  81
PHE A 118
GLY A 320
 None
 0.84A 4dm8B-3k6xA:
undetectable		 4dm8B-3k6xA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn1 PROBABLE YRBI FAMILY
PHOSPHATASE

(Pseudomonas
savastanoi) 		PF08282
(Hydrolase_3) 		5 LEU A  19
ALA A  20
LEU A  56
GLY A  50
LEU A  28
 None
None
None
CL  A 188 ( 3.7A)
None
 1.01A 4dm8B-3mn1A:
undetectable		 4dm8B-3mn1A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnm CURA

(Lyngbya
majuscula) 		PF05721
(PhyH) 		5 PHE A 103
LEU A 102
ALA A 101
GLY A 117
LEU A  55
 FMT  A 500 (-4.9A)
None
FMT  A 750 ( 4.0A)
None
None
 0.89A 4dm8B-3nnmA:
undetectable		 4dm8B-3nnmA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A  14
ALA A  15
LEU A  98
ILE A  60
GLY A  62
 None
 1.07A 4dm8B-3nx4A:
undetectable		 4dm8B-3nx4A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ong UBIQUITIN-ACTIVATING
ENZYME E1-LIKE

(Saccharomyces
cerevisiae) 		no annotation 5 PHE A 461
ILE A 509
ARG A 484
GLY A 444
LEU A 542
 None
 1.03A 4dm8B-3ongA:
undetectable		 4dm8B-3ongA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH

(Actinoplanes
sp. SE50/110) 		PF01547
(SBP_bac_1) 		5 PHE A 106
ALA A 331
ILE A 311
GLY A 291
LEU A 113
 None
 1.12A 4dm8B-3oo9A:
undetectable		 4dm8B-3oo9A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os6 ISOCHORISMATE
SYNTHASE DHBC

(Bacillus
anthracis) 		PF00425
(Chorismate_bind) 		5 LEU A 295
ALA A 296
LEU A 199
ILE A 344
LEU A  85
 None
None
None
None
SO4  A 405 ( 4.9A)
 1.04A 4dm8B-3os6A:
undetectable		 4dm8B-3os6A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 PHE A 223
LEU A 226
ALA A 227
LEU A 210
ILE A 184
 None
 0.90A 4dm8B-3pwzA:
undetectable		 4dm8B-3pwzA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe3 SORBITOL
DEHYDROGENASE

(Ovis aries) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 208
ALA A 211
ILE A 182
SER A 204
GLY A 159
 None
 1.03A 4dm8B-3qe3A:
undetectable		 4dm8B-3qe3A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkx UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR HI_0893

(Haemophilus
influenzae) 		PF00440
(TetR_N) 		5 ALA A 159
LEU A 105
LEU A 102
ILE A 101
LEU A 152
 None
 1.08A 4dm8B-3qkxA:
undetectable		 4dm8B-3qkxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwe GEM-INTERACTING
PROTEIN

(Homo sapiens) 		no annotation 5 LEU A  98
ALA A  97
LEU A  83
LEU A  87
GLY A  80
 None
 1.12A 4dm8B-3qweA:
undetectable		 4dm8B-3qweA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6h ENOYL-COA HYDRATASE,
ECHA3

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 PHE A 174
LEU A 112
ALA A 109
SER A 114
GLY A 159
 None
 0.92A 4dm8B-3r6hA:
undetectable		 4dm8B-3r6hA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		5 LEU A 279
LEU A 282
ILE A 283
GLY A 202
LEU A 263
 None
None
None
None
EDO  A 910 (-3.8A)
 1.05A 4dm8B-3s1sA:
undetectable		 4dm8B-3s1sA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8d COENZYME A
TRANSFERASE

(Yersinia pestis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ALA A 403
LEU A 421
ILE A 379
SER A 208
GLY A 330
 None
 0.95A 4dm8B-3s8dA:
undetectable		 4dm8B-3s8dA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqn CONSERVED DOMAIN
PROTEIN

(Enterococcus
faecalis) 		PF05043
(Mga) 		5 PHE A 376
LEU A 379
ALA A 380
LEU A 293
LEU A 318
 None
 1.07A 4dm8B-3sqnA:
undetectable		 4dm8B-3sqnA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue1 PENICILLIN-BINDING
PROTEIN 1A

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		5 PHE A 543
ALA A 442
ILE A 633
SER A 637
GLY A 512
 None
 1.12A 4dm8B-3ue1A:
undetectable		 4dm8B-3ue1A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ALA A 672
LEU A 745
LEU A 741
ILE A 744
LEU A 556
 None
 1.10A 4dm8B-3ui7A:
undetectable		 4dm8B-3ui7A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9r UNCHARACTERIZED
PROTEIN YDL160C-A
UNCHARACTERIZED
PROTEIN YOL086W-A

(Saccharomyces
cerevisiae) 		PF09415
(CENP-X)
PF15630
(CENP-S) 		5 LEU A  47
ALA A  45
LEU A  41
ILE A  38
LEU B   2
 None
 1.05A 4dm8B-3v9rA:
undetectable		 4dm8B-3v9rA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkw REPLICASE LARGE
SUBUNIT

(Tobacco mosaic
virus) 		PF01443
(Viral_helicase1) 		5 LEU A 687
ALA A 684
LEU A 728
ILE A 727
SER A 718
 None
 1.08A 4dm8B-3vkwA:
undetectable		 4dm8B-3vkwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbz LIKELY HISTIDYL
TRNA-SPECIFIC
GUANYLYLTRANSFERASE

(Candida
albicans) 		PF04446
(Thg1)
PF14413
(Thg1C) 		5 LEU A  61
ALA A  58
ILE A 213
ARG A 216
GLY A 211
 None
 1.11A 4dm8B-3wbzA:
undetectable		 4dm8B-3wbzA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF02156
(Glyco_hydro_26)
PF16990
(CBM_35) 		5 ALA A 214
LEU A 283
LEU A 286
ARG A 448
LEU A 227
 None
 1.11A 4dm8B-3zm8A:
undetectable		 4dm8B-3zm8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpx LIPASE

(Ustilago maydis) 		PF03583
(LIP) 		5 LEU A 241
ALA A 242
LEU A 256
ILE A 290
GLY A 260
 None
 0.96A 4dm8B-3zpxA:
undetectable		 4dm8B-3zpxA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs7 PYRIDOXAL KINASE

(Trypanosoma
brucei) 		PF08543
(Phos_pyr_kin) 		5 LEU A 235
ALA A 232
LEU A  81
ILE A  80
SER A 239
 None
 1.11A 4dm8B-3zs7A:
undetectable		 4dm8B-3zs7A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		5 LEU A  10
ALA A   9
LEU A 429
PHE A 422
GLY A 424
 None
 0.83A 4dm8B-4aoaA:
undetectable		 4dm8B-4aoaA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		5 LEU A 244
ILE A 186
ARG A 191
GLY A  83
LEU A 141
 None
 1.03A 4dm8B-4av6A:
undetectable		 4dm8B-4av6A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c76 FMN REDUCTASE
(NADPH)

(Pseudomonas
putida) 		PF03358
(FMN_red) 		5 ALA A  76
LEU A  80
LEU A  79
SER A 105
LEU A  36
 None
None
None
NA  A 201 (-4.8A)
None
 1.08A 4dm8B-4c76A:
undetectable		 4dm8B-4c76A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 LEU A  26
ALA A  23
LEU A  51
ILE A  48
ARG A   6
 None
 1.05A 4dm8B-4da9A:
undetectable		 4dm8B-4da9A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Thermobispora
bispora) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 PHE A 183
LEU A 176
LEU A 188
LEU A 146
LEU A 165
 None
 1.06A 4dm8B-4dhgA:
undetectable		 4dm8B-4dhgA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di4 TATP(T) (TP0957)

(Treponema
pallidum) 		PF03480
(DctP) 		5 PHE B  79
ALA B  77
LEU B  53
SER B 233
GLY B  54
 None
 1.08A 4dm8B-4di4B:
undetectable		 4dm8B-4di4B:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di4 TATP(T) (TP0957)

(Treponema
pallidum) 		PF03480
(DctP) 		5 PHE B  79
LEU B 231
ALA B  77
LEU B  53
GLY B  54
 None
 1.00A 4dm8B-4di4B:
undetectable		 4dm8B-4di4B:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3p GLUTAMINE-BINDING
PERIPLASMIC PROTEIN

(Burkholderia
pseudomallei) 		PF00497
(SBP_bac_3) 		6 LEU A 113
ALA A 114
LEU A 185
SER A 111
GLY A 192
LEU A 169
 None
 1.43A 4dm8B-4f3pA:
undetectable		 4dm8B-4f3pA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4

(Homo sapiens) 		PF00069
(Pkinase) 		5 PHE B 116
LEU B 152
LEU B 284
ILE B 288
GLY B 105
 None
None
None
None
GOL  B1000 ( 3.9A)
 1.07A 4dm8B-4fzdB:
undetectable		 4dm8B-4fzdB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8t GLUCARATE
DEHYDRATASE

(Actinobacillus
succinogenes) 		PF13378
(MR_MLE_C) 		5 PHE A 347
PHE A  32
LEU A 374
SER A 336
LEU A 409
 None
 1.06A 4dm8B-4g8tA:
undetectable		 4dm8B-4g8tA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 PHE A 473
LEU A 449
ILE A 405
GLY A 417
LEU A 439
 None
 1.12A 4dm8B-4ggaA:
undetectable		 4dm8B-4ggaA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF02811
(PHP) 		5 LEU A 142
LEU A 145
ILE A 146
ARG A 152
GLY A 112
 None
 0.90A 4dm8B-4gx8A:
undetectable		 4dm8B-4gx8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hs4 CHROMATE REDUCTASE

(Komagataeibacter
hansenii) 		PF03358
(FMN_red) 		5 LEU A  65
ALA A  68
LEU A  12
ILE A  45
LEU A 138
 None
 1.11A 4dm8B-4hs4A:
undetectable		 4dm8B-4hs4A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hts SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC

(Aquifex
aeolicus) 		PF00902
(TatC) 		5 PHE A  36
LEU A  39
ALA A  40
LEU A  52
ILE A  53
 None
 1.06A 4dm8B-4htsA:
undetectable		 4dm8B-4htsA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		5 PHE A 297
ALA A  43
LEU A 136
SER A  47
GLY A 141
 None
 0.98A 4dm8B-4l6uA:
undetectable		 4dm8B-4l6uA:
23.58