SIMILAR PATTERNS OF AMINO ACIDS FOR 4DJE_B_C2FB302_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad1 DIHYDROPTEROATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00809
(Pterin_bind) 		5 ASP A  45
ASP A  84
ASN A 103
ASP A 167
SER A 201
 None
 1.04A 4djeB-1ad1A:
22.4		 4djeB-1ad1A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajz DIHYDROPTEROATE
SYNTHASE

(Escherichia
coli) 		PF00809
(Pterin_bind) 		6 ASP A  56
ASP A  96
ASN A 115
ASP A 185
GLY A 217
SER A 219
 None
 1.06A 4djeB-1ajzA:
21.4		 4djeB-1ajzA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eye DIHYDROPTEROATE
SYNTHASE I

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		6 ASP A  47
ASP A  86
ASN A 105
ASP A 177
GLY A 209
SER A 211
 None
PMM  A 301 (-3.2A)
PMM  A 301 (-2.9A)
PMM  A 301 (-3.1A)
PMM  A 301 (-3.5A)
None
 0.82A 4djeB-1eyeA:
21.1		 4djeB-1eyeA:
24.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		11 GLU A   6
MET A  11
PHE A  12
ASP A  43
ASP A  75
ASN A  96
ASP A 160
GLY A 196
SER A 198
GLN A 202
ARG A 207
 None
 0.69A 4djeB-1f6yA:
42.9		 4djeB-1f6yA:
99.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		6 MET A  11
ASN A  96
ASP A 160
ASN A 199
GLN A 202
ARG A 207
 None
 1.10A 4djeB-1f6yA:
42.9		 4djeB-1f6yA:
99.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		7 MET A  11
PHE A  12
ASP A  75
ASP A 160
GLY A 196
GLN A 202
ARG A 207
 None
 1.35A 4djeB-1f6yA:
42.9		 4djeB-1f6yA:
99.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 ASP A 343
ASN A 321
GLY A 265
ASN A 266
ARG A 275
 None
None
None
CA  A 751 ( 3.2A)
None
 1.36A 4djeB-1flgA:
undetectable		 4djeB-1flgA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 ASP A 330
ASN A 308
GLY A 260
ASN A 261
ARG A 270
 None
None
None
CA  A 702 (-3.1A)
None
 1.32A 4djeB-1lrwA:
undetectable		 4djeB-1lrwA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psz PROTEIN (SURFACE
ANTIGEN PSAA)

(Streptococcus
pneumoniae) 		PF01297
(ZnuA) 		5 GLU A 254
ASP A 280
ASP A 137
GLY A 206
SER A 204
 None
ZN  A1000 ( 2.2A)
None
None
None
 1.21A 4djeB-1pszA:
undetectable		 4djeB-1pszA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrp PEPSIN 3A

(Homo sapiens) 		PF00026
(Asp) 		5 PHE E 111
ASP E  32
GLY E 302
SER E 219
GLN E 287
 HH0  E 327 (-4.6A)
HH0  E 327 (-2.7A)
None
HH0  E 327 (-3.0A)
HH0  E 327 ( 3.6A)
 1.08A 4djeB-1qrpE:
undetectable		 4djeB-1qrpE:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tww DHPS,
DIHYDROPTEROATE
SYNTHASE

(Bacillus
anthracis) 		PF00809
(Pterin_bind) 		6 ASP A  61
ASP A 101
ASN A 120
ASP A 184
GLY A 216
SER A 218
 None
HH2  A 282 (-3.4A)
HH2  A 282 (-2.7A)
HH2  A 282 (-3.1A)
HH2  A 282 (-3.3A)
None
 0.80A 4djeB-1twwA:
23.1		 4djeB-1twwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzs CATHEPSIN E

(Homo sapiens) 		PF00026
(Asp) 		5 GLU A  24
ASP A  43
GLY A 318
SER A 232
GLN A 303
 None
 1.09A 4djeB-1tzsA:
undetectable		 4djeB-1tzsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1

(Rattus
norvegicus) 		PF00996
(GDI) 		5 MET A 551
PHE A 549
ASP A  92
ASP A  38
GLY A  44
 None
 1.19A 4djeB-1vg0A:
undetectable		 4djeB-1vg0A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 ASP A 330
ASN A 308
GLY A 260
ASN A 261
ARG A 270
 None
None
None
CA  A1599 ( 3.5A)
None
 1.30A 4djeB-1w6sA:
undetectable		 4djeB-1w6sA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1

(Saccharomyces
cerevisiae) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		6 ASP A 591
ASP A 636
ASN A 655
ASP A 755
GLY A 803
SER A 805
 None
PMM  A1865 (-3.3A)
PMM  A1865 (-2.9A)
PMM  A1865 (-3.2A)
PMM  A1865 (-3.5A)
None
 0.74A 4djeB-2bmbA:
20.1		 4djeB-2bmbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bod ENDOGLUCANASE E-2

(Thermobifida
fusca) 		PF01341
(Glyco_hydro_6) 		5 GLU X 197
ASP X 218
ASP X 117
GLY X 158
SER X 160
 None
None
SGC  X1288 (-3.8A)
None
None
 1.36A 4djeB-2bodX:
7.4		 4djeB-2bodX:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqw DIHYDROPTEROATE
SYNTHASE

(Thermus
thermophilus) 		PF00809
(Pterin_bind) 		6 ASP A  70
ASP A 109
ASN A 128
ASP A 197
GLY A 229
SER A 231
 None
 1.14A 4djeB-2dqwA:
21.3		 4djeB-2dqwA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K

(Homo sapiens) 		PF00481
(PP2C) 		5 ASP A 127
ASP A 298
ASP A 225
GLY A 207
SER A 263
 MG  A   1 (-2.8A)
MG  A   1 ( 3.6A)
None
None
None
 1.37A 4djeB-2iq1A:
undetectable		 4djeB-2iq1A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg8 DPGC

(Streptomyces
toyocaensis) 		PF00378
(ECH_1) 		5 GLU A 189
MET A 197
ASP A 190
ASP A 184
SER A 232
 YE1  A 997 (-2.3A)
None
None
None
None
 1.28A 4djeB-2pg8A:
undetectable		 4djeB-2pg8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pm9 PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ASP A 322
ASN A 301
ASP A 279
GLY A 277
SER A 262
 None
 1.40A 4djeB-2pm9A:
undetectable		 4djeB-2pm9A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pm9 PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 PHE A  13
ASP A 322
ASP A 279
GLY A 277
SER A 262
 None
 1.39A 4djeB-2pm9A:
undetectable		 4djeB-2pm9A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056

(Geobacillus
kaustophilus) 		PF08282
(Hydrolase_3) 		5 GLU A 213
ASP A 211
ASP A   9
SER A 183
GLN A  68
 None
 1.47A 4djeB-2pq0A:
undetectable		 4djeB-2pq0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkb RIBONUCLEASE H1

(Homo sapiens) 		PF00075
(RNase_H) 		5 ASP A 274
ASP A 145
ASN A 210
SER A 149
GLN A 180
 None
C  C  12 ( 2.9A)
A  C  11 ( 3.1A)
U  C  14 ( 4.9A)
None
 1.39A 4djeB-2qkbA:
undetectable		 4djeB-2qkbA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vef DIHYDROPTEROATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00809
(Pterin_bind) 		6 ASP A  51
ASP A  91
ASN A 110
ASP A 201
GLY A 233
SER A 235
 None
 0.76A 4djeB-2vefA:
21.2		 4djeB-2vefA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5j DIHYDROPTEROATE
SYNTHASE

(Burkholderia
cenocepacia) 		PF00809
(Pterin_bind) 		6 ASP A  62
ASP A 101
ASN A 120
ASP A 191
GLY A 229
SER A 231
 None
None
None
None
None
EDO  A1294 (-2.6A)
 0.74A 4djeB-2y5jA:
20.3		 4djeB-2y5jA:
22.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		5 ASP A  44
ASP A 161
GLY A 197
ASN A 200
GLN A 203
 C2F  A3000 ( 4.5A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.1A)
C2F  A3000 (-3.9A)
 1.32A 4djeB-2ycjA:
41.5		 4djeB-2ycjA:
60.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		10 GLU A   7
PHE A  13
ASP A  44
ASP A  76
ASN A  97
ASP A 161
GLY A 197
SER A 199
ASN A 200
ARG A 208
 C2F  A3000 ( 4.1A)
C2F  A3000 (-3.9A)
C2F  A3000 ( 4.5A)
C2F  A3000 (-3.4A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.6A)
GOL  A1270 ( 3.9A)
C2F  A3000 (-3.1A)
C2F  A3000 ( 2.6A)
 0.67A 4djeB-2ycjA:
41.5		 4djeB-2ycjA:
60.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		8 GLU A   7
PHE A  13
ASP A 161
GLY A 197
SER A 199
ASN A 200
GLN A 203
ARG A 208
 C2F  A3000 ( 4.1A)
C2F  A3000 (-3.9A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.6A)
GOL  A1270 ( 3.9A)
C2F  A3000 (-3.1A)
C2F  A3000 (-3.9A)
C2F  A3000 ( 2.6A)
 0.90A 4djeB-2ycjA:
41.5		 4djeB-2ycjA:
60.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		5 MET A  12
ASP A  44
ASP A  76
ASN A  97
ASP A 161
 None
C2F  A3000 ( 4.5A)
C2F  A3000 (-3.4A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
 1.18A 4djeB-2ycjA:
41.5		 4djeB-2ycjA:
60.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		6 PHE A  13
ASP A  76
ASP A 161
GLY A 197
ASN A 200
ARG A 208
 C2F  A3000 (-3.9A)
C2F  A3000 (-3.4A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.1A)
C2F  A3000 ( 2.6A)
 1.28A 4djeB-2ycjA:
41.5		 4djeB-2ycjA:
60.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		5 GLU A 229
ASP A 222
ASP A 224
ASP A 208
GLN A 178
 CA  A1001 (-2.2A)
CA  A1005 ( 2.2A)
CA  A1005 (-3.3A)
CA  A1003 (-2.7A)
None
 1.48A 4djeB-2z2zA:
2.6		 4djeB-2z2zA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		5 MET A 961
PHE A 918
ASP A1002
GLY A1008
GLN A 449
 None
 1.02A 4djeB-3aibA:
4.1		 4djeB-3aibA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		5 ASP A  51
GLY A  46
SER A  81
ASN A  80
ARG A 484
 None
 1.45A 4djeB-3aivA:
5.6		 4djeB-3aivA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		7 GLU A 320
ASP A 358
ASP A 390
ASN A 411
ASP A 473
GLY A 505
SER A 507
 None
 0.73A 4djeB-3bolA:
25.8		 4djeB-3bolA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 GLU A 254
MET A 174
ASP A 227
GLY A 257
SER A 276
 NTM  A 300 ( 4.5A)
NTM  A 300 (-3.6A)
None
None
NTM  A 300 (-3.7A)
 1.33A 4djeB-3c2oA:
2.7		 4djeB-3c2oA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1

(Homo sapiens) 		PF00071
(Ras) 		5 GLU A  95
PHE A  99
ASP A 165
GLY A  34
SER A  36
 MG  A 302 ( 2.6A)
None
None
GNP  A 301 (-3.2A)
MG  A 302 ( 2.1A)
 1.06A 4djeB-3c5hA:
undetectable		 4djeB-3c5hA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnh HYDROLASE FAMILY
PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		5 GLU A 109
ASN A 169
GLY A  11
ASN A  17
GLN A  23
 PO4  A 201 ( 4.6A)
None
PO4  A 201 ( 3.5A)
None
None
 1.43A 4djeB-3cnhA:
undetectable		 4djeB-3cnhA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh8 METAL ABC
TRANSPORTER
SUBSTRATE-BINDING
LIPOPROTEIN

(Streptococcus
pyogenes) 		PF01297
(ZnuA) 		5 GLU A 254
ASP A 280
ASP A 137
GLY A 206
SER A 204
 None
FE  A 401 (-2.1A)
None
None
None
 1.22A 4djeB-3hh8A:
undetectable		 4djeB-3hh8A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 GLU A 203
ASP A 199
ASP A 280
GLY A 238
GLN A 360
 GOL  A 542 (-4.3A)
None
None
None
None
 1.41A 4djeB-3hztA:
undetectable		 4djeB-3hztA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		5 ASP A 172
ASP A 174
ASN A 177
GLY A 392
GLN A 401
 None
 1.30A 4djeB-3j4sA:
undetectable		 4djeB-3j4sA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzy INTERSECTIN 2

(Homo sapiens) 		PF00168
(C2) 		5 ASP A1610
ASP A1612
ASN A1563
ASP A1582
GLY A1560
 None
 1.25A 4djeB-3jzyA:
undetectable		 4djeB-3jzyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		5 ASP A 396
ASN A 452
ASP A 519
GLY A 558
ASN A 561
 THH  A 642 ( 4.7A)
THH  A 642 (-3.0A)
THH  A 642 (-3.4A)
THH  A 642 (-3.3A)
THH  A 642 ( 3.3A)
 1.29A 4djeB-3k13A:
28.8		 4djeB-3k13A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		9 GLU A 358
ASP A 396
ASP A 431
ASN A 452
ASP A 519
GLY A 558
SER A 560
ASN A 561
ARG A 573
 THH  A 642 ( 3.5A)
THH  A 642 ( 4.7A)
THH  A 642 (-3.3A)
THH  A 642 (-3.0A)
THH  A 642 (-3.4A)
THH  A 642 (-3.3A)
K  A 644 ( 3.4A)
THH  A 642 ( 3.3A)
THH  A 642 (-3.1A)
 0.59A 4djeB-3k13A:
28.8		 4djeB-3k13A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 PHE A 446
ASP A 452
ASP A 488
GLY A 464
SER A 462
 None
 1.50A 4djeB-3lmkA:
3.1		 4djeB-3lmkA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, ALPHA
SUBUNIT
PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis;
Alcaligenes
faecalis) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		5 PHE A  18
ASP B 529
ASP A  10
ASP B 493
GLY B  46
 None
 1.40A 4djeB-3ml0A:
undetectable		 4djeB-3ml0A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7q L-FUCOSE-PROTON
SYMPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		5 ASP A  46
GLY A 165
SER A 163
ASN A 162
GLN A 159
 None
None
None
BNG  A 439 (-2.9A)
BNG  A 439 ( 4.4A)
 1.09A 4djeB-3o7qA:
undetectable		 4djeB-3o7qA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg5 UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF13614
(AAA_31) 		5 GLU A 117
ASP A 160
GLY A 162
SER A 164
ASN A 169
 None
 1.37A 4djeB-3pg5A:
undetectable		 4djeB-3pg5A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwr ADNECTIN

(Homo sapiens) 		PF00041
(fn3) 		5 GLU D  38
ASP D  67
ASN D  91
GLY D  41
SER D  43
 None
 1.49A 4djeB-3qwrD:
undetectable		 4djeB-3qwrD:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr9 DIHYDROPTEROATE
SYNTHASE

(Coxiella
burnetii) 		PF00809
(Pterin_bind) 		5 ASP A  67
ASN A 130
ASP A 199
GLY A 234
SER A 236
 None
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
PT1  A1001 (-3.9A)
None
 1.15A 4djeB-3tr9A:
21.8		 4djeB-3tr9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr9 DIHYDROPTEROATE
SYNTHASE

(Coxiella
burnetii) 		PF00809
(Pterin_bind) 		6 ASP A  67
ASP A 111
ASN A 130
ASP A 199
GLY A 234
SER A 236
 None
PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
PT1  A1001 (-3.9A)
None
 0.82A 4djeB-3tr9A:
21.8		 4djeB-3tr9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujq LEGUME LECTIN

(Lablab
purpureus) 		PF00139
(Lectin_legB) 		5 ASP A 148
ASP A 156
ASN A 152
GLY A 125
ARG A  70
 CA  A 303 ( 3.0A)
MN  A 304 ( 2.6A)
CA  A 303 (-3.6A)
GAL  A 301 (-3.6A)
None
 1.36A 4djeB-3ujqA:
undetectable		 4djeB-3ujqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt0 CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		5 GLU A 209
ASP A 206
GLY A  12
SER A  14
GLN A  35
 ATP  A 400 (-4.4A)
MG  A 401 ( 4.4A)
ATP  A 400 (-3.3A)
ATP  A 400 (-3.7A)
None
 1.37A 4djeB-3wt0A:
undetectable		 4djeB-3wt0A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 5 GLU A  12
ASN A   7
GLY A 136
SER A 134
GLN A 133
 None
 1.42A 4djeB-3wvrA:
undetectable		 4djeB-3wvrA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx2 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 1

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		5 PHE A 364
ASP A 212
GLY A  56
SER A  58
GLN A  85
 None
 1.11A 4djeB-3zx2A:
undetectable		 4djeB-3zx2A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aah METHANOL
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF13360
(PQQ_2) 		5 ASP A 323
ASN A 302
GLY A 254
ASN A 255
ARG A 264
 None
None
None
CA  A 702 ( 3.0A)
None
 1.32A 4djeB-4aahA:
undetectable		 4djeB-4aahA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzk PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12931
(Sec16_C) 		5 ASP A 322
ASN A 301
ASP A 279
GLY A 277
SER A 262
 None
 1.40A 4djeB-4bzkA:
undetectable		 4djeB-4bzkA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzk PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12931
(Sec16_C) 		5 PHE A  13
ASP A 322
ASP A 279
GLY A 277
SER A 262
 None
 1.39A 4djeB-4bzkA:
undetectable		 4djeB-4bzkA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		6 ASP A 414
ASP A 449
ASN A 470
ASP A 537
ASN A 579
ARG A 585
 None
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
THG  A1652 (-3.3A)
 1.17A 4djeB-4cczA:
29.3		 4djeB-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		9 GLU A 376
ASP A 414
ASP A 449
ASN A 470
ASP A 537
GLY A 576
SER A 578
ASN A 579
ARG A 591
 THG  A1652 (-3.5A)
None
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
 0.59A 4djeB-4cczA:
29.3		 4djeB-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 MET A 207
PHE A 211
ASP A 199
ASN A 193
GLY A 155
 None
None
CA  A 703 (-2.3A)
None
None
 1.40A 4djeB-4jclA:
5.9		 4djeB-4jclA:
16.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		5 ASN A  97
ASP A 161
GLY A 196
ASN A 199
ARG A 207
 C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 4.3A)
None
 0.96A 4djeB-4o1eA:
33.4		 4djeB-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		6 ASP A  44
ASP A  76
ASN A  97
ASP A 161
GLY A 196
ARG A 207
 None
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
None
 1.01A 4djeB-4o1eA:
33.4		 4djeB-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		5 ASP A  44
ASP A  76
GLY A 196
SER A 198
ARG A 207
 None
C2F  A3000 (-3.6A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
None
 1.15A 4djeB-4o1eA:
33.4		 4djeB-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		6 GLU A   7
ASP A  44
ASP A  76
ASN A  97
ASP A 161
GLY A 196
 C2F  A3000 (-3.6A)
None
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
 0.60A 4djeB-4o1eA:
33.4		 4djeB-4o1eA:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA

(Staphylococcus
pseudintermedius) 		PF01297
(ZnuA) 		5 GLU A 252
ASP A 135
GLY A 204
SER A 202
GLN A 228
 None
 1.21A 4djeB-4oxrA:
undetectable		 4djeB-4oxrA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA

(Staphylococcus
pseudintermedius) 		PF01297
(ZnuA) 		5 GLU A 252
ASP A 278
ASP A 135
GLY A 204
SER A 202
 None
MN  A 401 (-2.0A)
None
None
None
 1.15A 4djeB-4oxrA:
undetectable		 4djeB-4oxrA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA

(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		5 MET A 142
PHE A 138
ASN B  47
ASP B 484
GLY B  66
 None
 1.25A 4djeB-4pelA:
undetectable		 4djeB-4pelA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		6 ASP A 209
ASP A 254
ASN A 276
ASP A 345
GLY A 378
SER A 380
 None
 0.81A 4djeB-4pzvA:
18.6		 4djeB-4pzvA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 MET A 483
ASN A 269
ASP A 273
GLY A 265
GLN A 424
 TPP  A 601 (-4.0A)
None
None
None
None
 1.38A 4djeB-4rjkA:
undetectable		 4djeB-4rjkA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 5 ASP B 357
ASN B 336
GLY B 288
ASN B 289
ARG B 298
 None
None
None
CA  B 701 ( 2.8A)
None
 1.32A 4djeB-4tqoB:
undetectable		 4djeB-4tqoB:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3A

(Lachancea
kluyveri) 		no annotation 5 MET a 187
PHE a 199
ASN a 281
SER a 259
ARG a 207
 None
 1.37A 4djeB-4uera:
undetectable		 4djeB-4uera:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4w PLEXIN-B1

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		5 ASP A 147
ASN A 146
GLY A 171
SER A 215
ARG A 235
 None
 1.48A 4djeB-5b4wA:
undetectable		 4djeB-5b4wA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmf DNA REPAIR HELICASE
RAD25, SSL2

(Saccharomyces
cerevisiae) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		5 GLU 1 683
PHE 1 705
ASP 1 610
ASN 1 781
GLY 1 678
 None
 1.31A 4djeB-5fmf1:
undetectable		 4djeB-5fmf1:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		5 GLU A 515
MET A 486
ASP A 267
ASN A 268
SER A 520
 None
None
CA  A 546 (-3.0A)
CA  A 546 (-2.9A)
None
 1.45A 4djeB-5g5zA:
undetectable		 4djeB-5g5zA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA

(Listeria
monocytogenes) 		PF01297
(ZnuA) 		5 GLU A 255
ASP A 138
GLY A 207
SER A 205
GLN A 231
 None
 1.15A 4djeB-5i4kA:
undetectable		 4djeB-5i4kA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA

(Listeria
monocytogenes) 		PF01297
(ZnuA) 		5 GLU A 255
ASP A 281
ASP A 138
GLY A 207
SER A 205
 None
MN  A 501 (-2.0A)
None
None
None
 1.23A 4djeB-5i4kA:
undetectable		 4djeB-5i4kA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jq9 DIHYDROPTEROATE
SYNTHASE

(Yersinia pestis) 		PF00809
(Pterin_bind) 		6 ASP A  56
ASP A  96
ASN A 115
ASP A 185
GLY A 217
SER A 219
 None
6MB  A 301 (-3.2A)
6MB  A 301 (-2.9A)
6MB  A 301 (-3.2A)
6MB  A 301 (-3.4A)
None
 0.73A 4djeB-5jq9A:
21.5		 4djeB-5jq9A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sui RIBOSOME BIOGENESIS
PROTEIN NSA1

(Saccharomyces
cerevisiae) 		no annotation 5 GLU A 312
ASP A 376
ASN A 320
GLY A 326
ARG A  54
 None
 1.38A 4djeB-5suiA:
undetectable		 4djeB-5suiA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umg DIHYDROPTEROATE
SYNTHASE

(Klebsiella
pneumoniae) 		PF00809
(Pterin_bind) 		5 ASP A  56
ASN A 115
ASP A 185
GLY A 217
SER A 219
 None
 0.98A 4djeB-5umgA:
21.1		 4djeB-5umgA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umg DIHYDROPTEROATE
SYNTHASE

(Klebsiella
pneumoniae) 		PF00809
(Pterin_bind) 		6 ASP A  56
ASP A  96
ASN A 115
ASP A 185
GLY A 217
SER A 219
 None
 0.94A 4djeB-5umgA:
21.1		 4djeB-5umgA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usw DIHYDROPTEROATE
SYNTHASE

(Aliivibrio
fischeri) 		PF00809
(Pterin_bind) 		6 ASP A  56
ASP A  96
ASN A 115
ASP A 185
GLY A 217
SER A 219
 None
GOL  A 303 ( 4.7A)
GOL  A 303 (-3.5A)
GOL  A 303 (-2.8A)
GOL  A 303 ( 3.9A)
None
 0.78A 4djeB-5uswA:
20.4		 4djeB-5uswA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 5 ASP A 443
ASP A 531
GLY A 570
ASN A 573
ARG A 583
 C2F  A3001 (-2.5A)
C2F  A3001 (-2.5A)
C2F  A3001 (-3.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.0A)
 0.76A 4djeB-5vopA:
30.2		 4djeB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 9 GLU A 373
ASP A 411
ASP A 443
ASN A 464
ASP A 531
GLY A 570
SER A 572
ASN A 573
ARG A 583
 C2F  A3001 (-3.7A)
C2F  A3001 ( 3.8A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 (-2.5A)
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.0A)
 0.61A 4djeB-5vopA:
30.2		 4djeB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvr KLLA0C04147P

(Kluyveromyces
lactis) 		PF01237
(Oxysterol_BP) 		5 ASP A1037
ASN A1032
GLY A 998
SER A 996
ASN A 997
 None
 1.35A 4djeB-5wvrA:
undetectable		 4djeB-5wvrA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE

(Methylophaga
aminisulfidivorans) 		no annotation 5 ASP A 361
ASN A 339
GLY A 291
ASN A 292
ARG A 301
 None
None
None
MG  A 702 ( 3.0A)
None
 1.33A 4djeB-5xm3A:
undetectable		 4djeB-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbb -

(-) 		no annotation 5 GLU A 273
PHE A 266
ASP A 271
SER A 292
GLN A 298
 None
 1.50A 4djeB-5zbbA:
undetectable		 4djeB-5zbbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6day DIHYDROPTEROATE
SYNTHASE

(Xanthomonas
albilineans) 		no annotation 6 ASP A  61
ASP A 101
ASN A 120
ASP A 190
GLY A 222
SER A 224
 None
 0.83A 4djeB-6dayA:
21.6		 4djeB-6dayA:
undetectable