SIMILAR PATTERNS OF AMINO ACIDS FOR 4DFB_A_KANA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Enterococcus
faecium) 		PF01636
(APH) 		5 ASP A 192
SER A 194
ASP A 213
TRP A 265
TYR A 272
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 0.98A 4dfbA-3hamA:
21.0		 4dfbA-3hamA:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n4t APH(2'')-ID

(Enterococcus
casseliflavus) 		PF01636
(APH) 		8 ASN A  32
ASP A 197
SER A 199
HIS A 202
ASP A 220
GLU A 239
TRP A 271
TYR A 278
 None
 0.46A 4dfbA-3n4tA:
42.9		 4dfbA-3n4tA:
93.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n4t APH(2'')-ID

(Enterococcus
casseliflavus) 		PF01636
(APH) 		5 ASP A 197
HIS A 202
ASP A 220
TRP A 287
TYR A 278
 None
 1.33A 4dfbA-3n4tA:
42.9		 4dfbA-3n4tA:
93.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n4t APH(2'')-ID

(Enterococcus
casseliflavus) 		PF01636
(APH) 		5 ASP A 197
HIS A 202
ASP A 220
TRP A 287
TYR A 282
 None
 1.12A 4dfbA-3n4tA:
42.9		 4dfbA-3n4tA:
93.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n4t APH(2'')-ID

(Enterococcus
casseliflavus) 		PF01636
(APH) 		5 ASP A 197
SER A 199
HIS A 202
ASP A 220
TYR A 282
 None
 1.16A 4dfbA-3n4tA:
42.9		 4dfbA-3n4tA:
93.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus) 		no annotation 5 ASP A 374
SER A 376
HIS A 379
ASP A 396
GLU A 416
 GNP  A 500 (-4.6A)
None
MG  A 700 ( 3.2A)
MG  A 702 ( 4.8A)
None
 0.44A 4dfbA-6ceyA:
30.6		 4dfbA-6ceyA:
13.65