SIMILAR PATTERNS OF AMINO ACIDS FOR 4DCM_A_SAMA401_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bhy | P64K (Neisseriameningitidis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 439GLY A 273ILE A 270ASP A 440PRO A 132 | FAD A 600 (-3.3A)FAD A 600 (-3.3A)NoneFAD A 600 (-2.7A)FAD A 600 (-3.4A) | 1.15A | 4dcmA-1bhyA:3.7 | 4dcmA-1bhyA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dus | MJ0882 (Methanocaldococcusjannaschii) |
PF05175(MTS) | 8 | PHE A 35ASP A 61GLY A 63GLY A 65ILE A 69ASP A 84ASN A 129PRO A 131 | None | 0.57A | 4dcmA-1dusA:14.5 | 4dcmA-1dusA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g0v | PROTEINASE A (Saccharomycescerevisiae) |
PF00026(Asp) | 5 | GLY A 34GLY A 217ILE A 214ASP A 32ASN A 37 | None | 0.90A | 4dcmA-1g0vA:undetectable | 4dcmA-1g0vA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h3g | CYCLOMALTODEXTRINASE (Flavobacteriumsp. 92) |
PF00128(Alpha-amylase)PF09087(Cyc-maltodext_N)PF10438(Cyc-maltodext_C) | 5 | GLY A 145GLY A 149ILE A 112ASP A 146ASN A 126 | CA A 700 ( 4.9A)NoneNone CA A 700 (-3.2A)None | 1.08A | 4dcmA-1h3gA:undetectable | 4dcmA-1h3gA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h7w | DIHYDROPYRIMIDINEDEHYDROGENASE (Sus scrofa) |
PF01180(DHO_dh)PF07992(Pyr_redox_2)PF14691(Fer4_20)PF14697(Fer4_21) | 5 | GLY A 480GLY A 284ILE A 281ASP A 481PRO A 197 | FAD A1031 (-3.4A)FAD A1031 (-3.6A)NoneFAD A1031 (-3.0A)FAD A1031 (-3.7A) | 1.10A | 4dcmA-1h7wA:3.2 | 4dcmA-1h7wA:15.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jsc | ACETOHYDROXY-ACIDSYNTHASE (Saccharomycescerevisiae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ALA A 504GLY A 549ILE A 547ASP A 550GLU A 578 | NoneTPP A 700 (-3.6A)None MG A 699 ( 2.8A)None | 1.03A | 4dcmA-1jscA:3.7 | 4dcmA-1jscA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lpf | DIHYDROLIPOAMIDEDEHYDROGENASE (Pseudomonasfluorescens) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 317GLY A 151ILE A 148ASP A 318PRO A 13 | FAD A 480 (-3.4A)FAD A 480 (-3.4A)NoneFAD A 480 (-2.9A)FAD A 480 (-3.5A) | 1.10A | 4dcmA-1lpfA:3.8 | 4dcmA-1lpfA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ne2 | HYPOTHETICAL PROTEINTA1320 (Thermoplasmaacidophilum) |
PF06325(PrmA) | 5 | ASP A 54GLY A 56GLY A 58ASN A 114PRO A 116 | None | 0.78A | 4dcmA-1ne2A:13.6 | 4dcmA-1ne2A:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ne2 | HYPOTHETICAL PROTEINTA1320 (Thermoplasmaacidophilum) |
PF06325(PrmA) | 5 | ASP A 54GLY A 56GLY A 58ASP A 78ASN A 114 | None | 0.43A | 4dcmA-1ne2A:13.6 | 4dcmA-1ne2A:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nw5 | MODIFICATIONMETHYLASE RSRI (Rhodobactersphaeroides) |
PF01555(N6_N4_Mtase) | 5 | ASP A 248GLY A 252ILE A 63ASP A 271PRO A 67 | NoneSAM A 401 (-3.3A)NoneSAM A 401 (-2.9A)SAM A 401 (-4.3A) | 0.86A | 4dcmA-1nw5A:4.3 | 4dcmA-1nw5A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ofe | FERREDOXIN-DEPENDENTGLUTAMATE SYNTHASE 2 (Synechocystissp. PCC 6803) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 5 | PHE A1383ALA A1375GLY A1361GLY A1380ILE A1359 | None | 1.09A | 4dcmA-1ofeA:undetectable | 4dcmA-1ofeA:14.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ri0 | HEPATOMA-DERIVEDGROWTH FACTOR (Homo sapiens) |
PF00855(PWWP) | 5 | PHE A 49ILE A 30GLU A 88ASN A 91PRO A 27 | None | 1.08A | 4dcmA-1ri0A:undetectable | 4dcmA-1ri0A:13.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sg9 | HEMK PROTEIN (Thermotogamaritima) |
PF05175(MTS) | 8 | PHE A 100ASP A 127GLY A 129GLY A 131ILE A 135ASP A 151ASN A 197PRO A 199 | SAM A 301 ( 3.4A)SAM A 301 ( 4.9A)SAM A 301 (-3.3A)SAM A 301 ( 3.8A)SAM A 301 (-4.8A)SAM A 301 (-2.9A)GLN A 400 ( 3.1A)SAM A 301 ( 4.6A) | 0.57A | 4dcmA-1sg9A:17.2 | 4dcmA-1sg9A:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tdf | THIOREDOXINREDUCTASE (Escherichiacoli) |
PF07992(Pyr_redox_2) | 5 | GLY A 285GLY A 113ILE A 110ASP A 286PRO A 15 | FAD A 500 (-3.1A)FAD A 500 (-3.5A)NoneFAD A 500 (-2.0A)FAD A 500 (-3.6A) | 1.10A | 4dcmA-1tdfA:2.7 | 4dcmA-1tdfA:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u3d | CRYPTOCHROME 1APOPROTEIN (Arabidopsisthaliana) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 5 | PHE A 18ALA A 29ASP A 139GLY A 257ASN A 27 | None | 1.00A | 4dcmA-1u3dA:undetectable | 4dcmA-1u3dA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wdw | TRYPTOPHAN SYNTHASEBETA CHAIN 1 (Pyrococcusfuriosus) |
PF00291(PALP) | 5 | ALA B 103GLY B 130GLY B 106ILE B 127ASP B 133 | None | 1.13A | 4dcmA-1wdwB:undetectable | 4dcmA-1wdwB:24.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wy7 | HYPOTHETICAL PROTEINPH1948 (Pyrococcushorikoshii) |
PF05175(MTS) | 5 | ASP A 55GLY A 57GLY A 59ASN A 119PRO A 121 | SAH A1001 ( 4.5A)SAH A1001 (-3.4A)SAH A1001 (-3.3A)SAH A1001 (-4.6A)None | 0.48A | 4dcmA-1wy7A:16.9 | 4dcmA-1wy7A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xnt | PROTEIN (DNA-REPAIRPROTEIN XRCC1) (Homo sapiens) |
PF01834(XRCC1_N) | 5 | GLY A 143GLY A 64ASP A 63ASN A 23PRO A 141 | None | 0.91A | 4dcmA-1xntA:undetectable | 4dcmA-1xntA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xzw | PURPLE ACIDPHOSPHATASE (Ipomoea batatas) |
PF00149(Metallophos)PF14008(Metallophos_C)PF16656(Pur_ac_phosph_N) | 6 | GLY A 39GLY A 33ILE A 42ASP A 34GLU A 36PRO A 118 | None | 1.16A | 4dcmA-1xzwA:undetectable | 4dcmA-1xzwA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y8t | HYPOTHETICAL PROTEINRV0983 (Mycobacteriumtuberculosis) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 6 | ALA A 163GLY A 167GLY A 121ILE A 164GLU A 23ASN A 165 | None | 1.11A | 4dcmA-1y8tA:undetectable | 4dcmA-1y8tA:26.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yq2 | BETA-GALACTOSIDASE (Arthrobactersp. C2-2) |
PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 5 | ASP A 882GLY A 883GLY A 939ASP A 936GLU A 934 | None | 1.00A | 4dcmA-1yq2A:undetectable | 4dcmA-1yq2A:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a8x | DIHYDROLIPOYLDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 308GLY A 143ILE A 140ASP A 309PRO A 13 | FAD A 480 (-3.2A)FAD A 480 (-3.2A)NoneFAD A 480 (-2.8A)FAD A 480 (-4.0A) | 1.12A | 4dcmA-2a8xA:2.6 | 4dcmA-2a8xA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b3t | PROTEINMETHYLTRANSFERASEHEMK (Escherichiacoli) |
PF13847(Methyltransf_31) | 7 | ASP A 115GLY A 117GLY A 119ILE A 123ASP A 140ASN A 183PRO A 185 | NoneSAH A 300 (-3.4A)SAH A 300 (-3.5A)NoneSAH A 300 (-3.1A)SAH A 300 (-3.9A)SAH A 300 ( 3.9A) | 0.48A | 4dcmA-2b3tA:20.2 | 4dcmA-2b3tA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bkl | PROLYL ENDOPEPTIDASE (Myxococcusxanthus) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 5 | ALA A 542GLY A 452GLY A 535ILE A 529ASN A 459 | None | 1.14A | 4dcmA-2bklA:undetectable | 4dcmA-2bklA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cyg | BETA-1, 3-GLUCANANSE (Musa acuminata) |
PF00332(Glyco_hydro_17) | 5 | ALA A 136GLY A 98ILE A 140ASP A 99ASN A 139 | None | 0.96A | 4dcmA-2cygA:undetectable | 4dcmA-2cygA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h00 | METHYLTRANSFERASE 10DOMAIN CONTAININGPROTEIN (Homo sapiens) |
PF05971(Methyltransf_10) | 5 | ASP A 71GLY A 73GLY A 75ASN A 147PRO A 149 | SAH A 300 ( 4.2A)SAH A 300 (-3.1A)SAH A 300 (-3.6A)SAH A 300 (-3.9A)SAH A 300 (-4.0A) | 0.66A | 4dcmA-2h00A:14.4 | 4dcmA-2h00A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h1r | DIMETHYLADENOSINETRANSFERASE,PUTATIVE (Plasmodiumfalciparum) |
PF00398(RrnaAD) | 5 | GLY A 29GLY A 31ASP A 50ASN A 92PRO A 94 | None | 0.90A | 4dcmA-2h1rA:10.7 | 4dcmA-2h1rA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iht | CARBOXYETHYLARGININESYNTHASE (Streptomycesclavuligerus) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ASP A 409GLY A 462GLY A 464ILE A 410GLU A 556 | NoneTPP A 600 (-3.4A)TPP A 600 (-3.5A)TPP A 600 (-4.5A)None | 1.12A | 4dcmA-2ihtA:undetectable | 4dcmA-2ihtA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o52 | RAS-RELATED PROTEINRAB-4B (Homo sapiens) |
PF00071(Ras) | 5 | ALA A 152GLY A 18GLU A 94ASN A 97ASN A 121 | GDP A 601 (-3.6A)GDP A 601 (-3.5A)NoneNoneGDP A 601 (-3.3A) | 1.09A | 4dcmA-2o52A:3.6 | 4dcmA-2o52A:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ozv | HYPOTHETICAL PROTEINATU0636 (Agrobacteriumfabrum) |
PF05175(MTS) | 5 | ALA A 33ASP A 50GLY A 52ASN A 130PRO A 132 | None | 0.94A | 4dcmA-2ozvA:11.8 | 4dcmA-2ozvA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p35 | TRANS-ACONITATE2-METHYLTRANSFERASE (Agrobacteriumfabrum) |
PF13489(Methyltransf_23) | 5 | ASP A 36GLY A 38GLY A 40ASP A 61ASN A 99 | SAH A 301 ( 4.4A)SAH A 301 (-3.6A)SAH A 301 (-3.3A)SAH A 301 (-2.7A)SAH A 301 (-3.8A) | 0.93A | 4dcmA-2p35A:11.9 | 4dcmA-2p35A:24.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pjd | RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE C (Escherichiacoli) |
PF05175(MTS)PF08468(MTS_N) | 7 | ASP A 202GLY A 204GLY A 206ASP A 227ASN A 253ASN A 268PRO A 270 | None | 0.71A | 4dcmA-2pjdA:31.3 | 4dcmA-2pjdA:27.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q0l | THIOREDOXINREDUCTASE (Helicobacterpylori) |
PF07992(Pyr_redox_2) | 5 | GLY A 280GLY A 111ILE A 108ASP A 281PRO A 11 | FAD A 400 (-3.3A)FAD A 400 (-3.3A)NoneFAD A 400 (-2.7A)FAD A 400 (-3.4A) | 1.05A | 4dcmA-2q0lA:3.4 | 4dcmA-2q0lA:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ru4 | ARMADILLO REPEATPROTEIN, N-TERMINALFRAGMENT, YIIM2 (syntheticconstruct) |
PF00514(Arm) | 5 | ALA A 108GLY A 74ILE A 112GLU A 34ASN A 111 | None | 1.10A | 4dcmA-2ru4A:undetectable | 4dcmA-2ru4A:14.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdc | GLUTAMATE SYNTHASE[NADPH] LARGE CHAIN (Azospirillumbrasilense) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 5 | PHE A1346ALA A1338GLY A1324GLY A1343ILE A1322 | None | 1.07A | 4dcmA-2vdcA:undetectable | 4dcmA-2vdcA:13.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zfu | CEREBRAL PROTEIN 1 (Homo sapiens) |
PF05148(Methyltransf_8) | 5 | PHE A 284ASP A 314GLY A 316GLY A 318ASP A 334 | SAH A 900 (-3.7A)SAH A 900 ( 4.6A)SAH A 900 (-3.5A)SAH A 900 ( 3.7A)SAH A 900 (-2.7A) | 0.68A | 4dcmA-2zfuA:12.1 | 4dcmA-2zfuA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zwv | PROBABLE RIBOSOMALRNA SMALL SUBUNITMETHYLTRANSFERASE (Thermusthermophilus) |
PF05175(MTS) | 6 | PHE A 207ASP A 239GLY A 241GLY A 243ASN A 305PRO A 307 | SAH A 376 (-3.4A)SAH A 376 ( 4.2A)SAH A 376 (-3.1A)SAH A 376 (-3.4A)SAH A 376 (-4.4A)SAH A 376 ( 4.3A) | 0.53A | 4dcmA-2zwvA:33.6 | 4dcmA-2zwvA:27.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3abi | PUTATIVEUNCHARACTERIZEDPROTEIN PH1688 (Pyrococcushorikoshii) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 5 | GLY A 7GLY A 9ILE A 15ASP A 29PRO A 70 | NAD A1001 ( 3.8A)NAD A1001 (-3.7A)NoneNAD A1001 (-2.9A)NAD A1001 (-3.8A) | 1.10A | 4dcmA-3abiA:5.4 | 4dcmA-3abiA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayf | NITRIC OXIDEREDUCTASE (Geobacillusstearothermophilus) |
PF00115(COX1) | 5 | GLY A 411GLY A 407ILE A 350GLU A 419ASN A 418 | None | 1.05A | 4dcmA-3ayfA:undetectable | 4dcmA-3ayfA:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ccf | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPIDSYNTHASE (Trichormusvariabilis) |
PF08241(Methyltransf_11) | 5 | ASP A 44GLY A 46GLY A 48ASP A 67ASN A 105 | None | 0.68A | 4dcmA-3ccfA:14.6 | 4dcmA-3ccfA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cgg | SAM-DEPENDENTMETHYLTRANSFERASE (Corynebacteriumglutamicum) |
PF13649(Methyltransf_25) | 5 | ASP A 51GLY A 53GLY A 55ILE A 59ASP A 74 | NoneNHE A 195 (-3.2A)NoneNoneNHE A 195 (-3.6A) | 0.47A | 4dcmA-3cggA:12.0 | 4dcmA-3cggA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cjt | RIBOSOMAL PROTEINL11METHYLTRANSFERASE (Thermusthermophilus) |
PF06325(PrmA) | 6 | PHE A 99ASP A 126GLY A 128GLY A 130ASP A 149ASN A 191 | SAH A 258 ( 4.3A)SAH A 258 ( 3.9A)SAH A 258 (-3.1A)SAH A 258 (-3.6A)SAH A 258 (-2.8A)SAH A 258 ( 3.8A) | 0.40A | 4dcmA-3cjtA:17.7 | 4dcmA-3cjtA:24.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e8s | PUTATIVE SAMDEPENDENTMETHYLTRANSFERASE (Pseudomonasputida) |
PF13489(Methyltransf_23) | 5 | ASP A 57GLY A 59GLY A 61ASP A 80ASN A 122 | SAH A 300 ( 4.7A)SAH A 300 (-4.2A)SAH A 300 (-3.1A)SAH A 300 (-2.7A)SAH A 300 (-3.8A) | 0.97A | 4dcmA-3e8sA:11.8 | 4dcmA-3e8sA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eka | HYALURONIDASE, PHAGEASSOCIATED (Streptococcuspyogenes) |
PF07212(Hyaluronidase_1) | 5 | PHE A 49ALA A 40GLY A 43ILE A 55ASP A 44 | None | 1.11A | 4dcmA-3ekaA:undetectable | 4dcmA-3ekaA:25.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3grz | RIBOSOMAL PROTEINL11METHYLTRANSFERASE (Lactobacillusdelbrueckii) |
PF06325(PrmA) | 5 | ASP A 182GLY A 184GLY A 186ASP A 206ASN A 248 | NoneGOL A 322 ( 3.7A)NoneGOL A 322 (-3.5A)None | 0.53A | 4dcmA-3grzA:18.3 | 4dcmA-3grzA:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ijp | DIHYDRODIPICOLINATEREDUCTASE (Bartonellahenselae) |
PF01113(DapB_N)PF05173(DapB_C) | 5 | ALA A 44GLY A 10GLY A 7ILE A 17ASN A 157 | NoneNAP A 300 (-3.3A)NAP A 300 (-3.3A)NoneNone | 1.05A | 4dcmA-3ijpA:5.2 | 4dcmA-3ijpA:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jwi | METHYLTRANSFERASETYPE 12 (Ruminiclostridiumthermocellum) |
PF08242(Methyltransf_12) | 5 | ASP A 35GLY A 37GLY A 39ILE A 109ASP A 60 | None | 0.82A | 4dcmA-3jwiA:11.7 | 4dcmA-3jwiA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k0b | PREDICTEDN6-ADENINE-SPECIFICDNA METHYLASE (Listeriamonocytogenes) |
PF01170(UPF0020)PF02926(THUMP) | 5 | ASP A 196GLY A 200ILE A 204ASP A 259ASN A 303 | None | 0.91A | 4dcmA-3k0bA:14.5 | 4dcmA-3k0bA:24.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ldg | PUTATIVEUNCHARACTERIZEDPROTEIN SMU.472 (Streptococcusmutans) |
PF01170(UPF0020)PF02926(THUMP) | 5 | ASP A 200GLY A 204ASP A 263ASN A 307PRO A 309 | NoneSAH A 385 (-3.4A)SAH A 385 (-2.8A)SAH A 385 (-4.3A)SAH A 385 (-4.2A) | 0.66A | 4dcmA-3ldgA:10.7 | 4dcmA-3ldgA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ldu | PUTATIVE METHYLASE (Clostridioidesdifficile) |
PF01170(UPF0020)PF02926(THUMP) | 5 | ASP A 198GLY A 202ILE A 206ASP A 261ASN A 305 | NoneGTP A 383 (-2.6A)NoneGTP A 383 (-3.0A)GTP A 383 (-4.2A) | 0.76A | 4dcmA-3lduA:10.5 | 4dcmA-3lduA:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ldu | PUTATIVE METHYLASE (Clostridioidesdifficile) |
PF01170(UPF0020)PF02926(THUMP) | 5 | GLY A 202ILE A 206ASP A 261ASN A 305PRO A 307 | GTP A 383 (-2.6A)NoneGTP A 383 (-3.0A)GTP A 383 (-4.2A)GTP A 383 (-3.7A) | 0.54A | 4dcmA-3lduA:10.5 | 4dcmA-3lduA:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lpm | PUTATIVEMETHYLTRANSFERASE (Listeriamonocytogenes) |
PF05175(MTS) | 5 | ALA A 37ASP A 55GLY A 59ILE A 63ASN A 126 | None | 0.62A | 4dcmA-3lpmA:20.6 | 4dcmA-3lpmA:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pr2 | TRYPTOPHAN SYNTHASEBETA CHAIN (Salmonellaenterica) |
PF00291(PALP) | 5 | ALA B 108GLY B 135GLY B 111ILE B 132ASP B 138 | NoneNone7MN B 2 (-3.7A)NoneNone | 1.09A | 4dcmA-3pr2B:2.5 | 4dcmA-3pr2B:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q87 | N6 ADENINE SPECIFICDNA METHYLASE (Encephalitozooncuniculi) |
PF05175(MTS) | 6 | ASP B 29GLY B 31ILE B 37ASP B 51ASN B 85PRO B 87 | SAM B 300 ( 4.7A)SAM B 300 (-3.5A)NoneSAM B 300 (-2.9A)SAM B 300 (-3.9A)SAM B 300 (-4.1A) | 0.41A | 4dcmA-3q87B:12.3 | 4dcmA-3q87B:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sm3 | SAM-DEPENDENTMETHYLTRANSFERASES (Methanosarcinamazei) |
PF08241(Methyltransf_11) | 6 | ASP A 36GLY A 38GLY A 40ILE A 44ASP A 59ASN A 91 | None | 0.62A | 4dcmA-3sm3A:13.2 | 4dcmA-3sm3A:24.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tma | METHYLTRANSFERASE (Thermusthermophilus) |
PF01170(UPF0020)PF02926(THUMP) | 6 | ASP A 190GLY A 194ILE A 198ASP A 216ASN A 260PRO A 262 | None | 0.68A | 4dcmA-3tmaA:17.1 | 4dcmA-3tmaA:24.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ze6 | PERIPLASMIC [NIFESE]HYDROGENASE, SMALLSUBUNIT (Desulfovibriovulgaris) |
PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 5 | ALA A 117GLY A 197ILE A 156ASP A 194PRO A 271 | None | 1.16A | 4dcmA-3ze6A:undetectable | 4dcmA-3ze6A:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bms | ALCLOHOLDEHYDROGENASE/SHORT-CHAIN DEHYDROGENASE (Ralstonia sp.DSMZ 6428) |
PF13561(adh_short_C2) | 5 | ALA A 46GLY A 13GLY A 37ILE A 35ASN A 111 | NoneNAP A1250 (-3.1A)NAP A1250 (-3.5A)NoneNone | 1.01A | 4dcmA-4bmsA:6.5 | 4dcmA-4bmsA:23.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dcm | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE G (Escherichiacoli) |
PF05175(MTS) | 11 | PHE A 208ALA A 217ASP A 234GLY A 236GLY A 238ILE A 242ASP A 259GLU A 260ASN A 289ASN A 305PRO A 307 | SAM A 401 (-3.6A)SAM A 401 (-3.2A)SAM A 401 ( 4.2A)SAM A 401 (-3.5A)SAM A 401 ( 3.7A)SAM A 401 (-4.7A)SAM A 401 (-2.9A)NoneSAM A 401 (-4.3A)SAM A 401 (-3.8A)SAM A 401 (-4.0A) | 0.04A | 4dcmA-4dcmA:60.9 | 4dcmA-4dcmA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dcm | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE G (Escherichiacoli) |
PF05175(MTS) | 6 | PHE A 208ALA A 217GLY A 236GLY A 238ASN A 288ASN A 305 | SAM A 401 (-3.6A)SAM A 401 (-3.2A)SAM A 401 (-3.5A)SAM A 401 ( 3.7A)NoneSAM A 401 (-3.8A) | 1.28A | 4dcmA-4dcmA:60.9 | 4dcmA-4dcmA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dzr | PROTEIN-(GLUTAMINE-N5)METHYLTRANSFERASE,RELEASEFACTOR-SPECIFIC (Alicyclobacillusacidocaldarius) |
PF05175(MTS) | 5 | ASP A 134GLY A 136GLY A 138ILE A 142ASP A 159 | None | 1.11A | 4dcmA-4dzrA:10.9 | 4dcmA-4dzrA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ep5 | CROSSOVER JUNCTIONENDODEOXYRIBONUCLEASE RUVC (Thermusthermophilus) |
PF02075(RuvC) | 5 | ALA A 149GLY A 14GLY A 16ILE A 150PRO A 141 | NoneNoneNoneNoneGOL A 205 (-4.2A) | 1.00A | 4dcmA-4ep5A:undetectable | 4dcmA-4ep5A:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4evi | CONIFERYL ALCOHOL9-O-METHYLTRANSFERASE (Linumnodiflorum) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | ASP A 206GLY A 208GLY A 210ASP A 231ASN A 252 | NoneSAH A 401 (-3.6A)SAH A 401 ( 3.8A)SAH A 401 (-2.9A)SAH A 401 (-3.3A) | 0.46A | 4dcmA-4eviA:11.0 | 4dcmA-4eviA:23.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gc5 | DIMETHYLADENOSINETRANSFERASE 1,MITOCHONDRIAL (Mus musculus) |
PF00398(RrnaAD) | 5 | GLY A 63GLY A 65ILE A 69ASN A 141PRO A 143 | ACT A 402 (-3.4A)NoneNoneNoneACT A 402 ( 4.9A) | 0.67A | 4dcmA-4gc5A:11.7 | 4dcmA-4gc5A:24.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hkt | INOSITOL2-DEHYDROGENASE (Sinorhizobiummeliloti) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | ALA A 42ASP A 34GLY A 9GLY A 11GLU A 92 | None | 1.04A | 4dcmA-4hktA:6.6 | 4dcmA-4hktA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jnq | THIOREDOXINREDUCTASE (Brucellamelitensis) |
PF07992(Pyr_redox_2) | 5 | GLY A 285GLY A 114ILE A 111ASP A 286PRO A 15 | FDA A 401 (-3.4A)FDA A 401 (-3.3A)NoneFDA A 401 (-3.0A)FDA A 401 (-3.6A) | 1.13A | 4dcmA-4jnqA:2.6 | 4dcmA-4jnqA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jq9 | DIHYDROLIPOYLDEHYDROGENASE (Escherichiacoli) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 312GLY A 146ILE A 143ASP A 313PRO A 16 | FAD A 512 (-3.4A)FAD A 512 (-3.4A)NoneFAD A 512 (-3.0A)FAD A 512 (-3.9A) | 1.14A | 4dcmA-4jq9A:3.7 | 4dcmA-4jq9A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4krg | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE1 (Haemonchuscontortus) |
PF08241(Methyltransf_11) | 5 | ASP A 57GLY A 59GLY A 61ASP A 80ASN A 122 | NoneSAH A 502 (-3.6A)SAH A 502 (-3.4A)SAH A 502 (-2.5A)SAH A 502 (-3.9A) | 0.79A | 4dcmA-4krgA:13.7 | 4dcmA-4krgA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4obw | 2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOLMETHYLASE,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF01209(Ubie_methyltran) | 5 | ASP A 117GLY A 121ILE A 125ASP A 148ASN A 179 | NoneNoneNoneSAM A 602 (-2.9A)SAM A 602 (-3.7A) | 0.78A | 4dcmA-4obwA:18.3 | 4dcmA-4obwA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rf3 | NADPH DEPENDENTR-SPECIFIC ALCOHOLDEHYDROGENASE (Lactobacilluskefiri) |
PF13561(adh_short_C2) | 5 | ALA A 47GLY A 14GLY A 38ILE A 36ASN A 114 | None | 0.99A | 4dcmA-4rf3A:5.3 | 4dcmA-4rf3A:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynn | PROTEASE DO (Legionellapneumophila) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | ALA A 184GLY A 188GLY A 143ILE A 185ASN A 186 | None | 1.09A | 4dcmA-4ynnA:undetectable | 4dcmA-4ynnA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z8z | UNCHARACTERIZEDPROTEIN (Ruminiclostridiumthermocellum) |
no annotation | 5 | PHE A 131ALA A 155GLY A 144ILE A 148GLU A 128 | None | 1.13A | 4dcmA-4z8zA:undetectable | 4dcmA-4z8zA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zgz | ANTIZYME INHIBITOR 1 (Homo sapiens) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 5 | ALA A 39GLY A 355GLY A 319ASP A 362ASN A 317 | None | 1.12A | 4dcmA-4zgzA:undetectable | 4dcmA-4zgzA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zn0 | THIOREDOXINREDUCTASE (Methanosarcinamazei) |
PF07992(Pyr_redox_2) | 5 | GLY A 276GLY A 111ILE A 108ASP A 277PRO A 14 | None | 1.08A | 4dcmA-4zn0A:3.6 | 4dcmA-4zn0A:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5afu | DYNACTIN (Sus scrofa) |
PF00022(Actin) | 5 | ALA J 354GLY J 308GLY J 142ILE J 306GLU J 208 | NoneADP J 800 ( 3.2A)ADP J 800 ( 3.1A)NoneADP J 800 ( 4.6A) | 1.11A | 4dcmA-5afuJ:undetectable | 4dcmA-5afuJ:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp9 | PUTATIVEMETHYLTRANSFERASEPROTEIN (Bacteroidesfragilis) |
PF13489(Methyltransf_23) | 5 | ASP A 86GLY A 88GLY A 90ASP A 109ASN A 130 | NoneSAH A 303 (-3.3A)SAH A 303 ( 3.7A)SAH A 303 (-2.7A)SAH A 303 (-3.0A) | 0.56A | 4dcmA-5bp9A:10.8 | 4dcmA-5bp9A:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bs5 | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Acinetobacterbaumannii) |
PF00275(EPSP_synthase) | 5 | PHE A 698GLY A 724GLY A 700ILE A 317PRO A 696 | None | 1.09A | 4dcmA-5bs5A:undetectable | 4dcmA-5bs5A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwa | ORNITHINEDECARBOXYLASE (Homo sapiens) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 5 | ALA A 39GLY A 357GLY A 321ASP A 364ASN A 319 | None | 1.12A | 4dcmA-5bwaA:undetectable | 4dcmA-5bwaA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dly | PLANTAZOLICINMETHYLTRANSFERASEBAML (Bacillusvelezensis) |
PF13847(Methyltransf_31) | 5 | ASP A 66GLY A 68GLY A 70ASP A 91ASN A 113 | SAH A 301 ( 4.7A)SAH A 301 (-3.6A)SAH A 301 ( 3.7A)SAH A 301 (-2.8A)SAH A 301 (-3.8A) | 0.46A | 4dcmA-5dlyA:11.5 | 4dcmA-5dlyA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e1b | N-TERMINALXAA-PRO-LYSN-METHYLTRANSFERASE1 (Homo sapiens) |
PF05891(Methyltransf_PK) | 5 | ASP A 67GLY A 69GLY A 71ILE A 75ASP A 91 | NoneSAH A 301 (-3.9A)SAH A 301 (-3.1A)NoneSAH A 301 (-2.7A) | 0.43A | 4dcmA-5e1bA:13.1 | 4dcmA-5e1bA:24.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5evj | ARSENITEMETHYLTRANSFERASE (Chlamydomonasreinhardtii) |
PF13847(Methyltransf_31) | 5 | ASP A 89GLY A 91GLY A 93ASP A 115ASN A 169 | None | 0.78A | 4dcmA-5evjA:14.2 | 4dcmA-5evjA:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fad | RIBOSOMAL PROTEINL11METHYLTRANSFERASE,PUTATIVE (Sulfolobusislandicus) |
PF13847(Methyltransf_31) | 5 | ASP A 34GLY A 36GLY A 38ILE A 42ASN A 87 | SAH A 201 (-2.9A)SAH A 201 (-3.0A)SAH A 201 (-3.5A)NoneSAH A 201 (-3.7A) | 0.95A | 4dcmA-5fadA:11.8 | 4dcmA-5fadA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fji | BETA-GLUCOSIDASE (Aspergillusfumigatus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | ALA A 506GLY A 573ILE A 549ASN A 581ASN A 505 | NoneNoneNoneEDO A1867 (-4.4A)None | 1.14A | 4dcmA-5fjiA:undetectable | 4dcmA-5fjiA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ihe | DNA POLYMERASE IISMALL SUBUNIT (Pyrococcusabyssi) |
PF00149(Metallophos) | 5 | GLY A 403GLY A 559ILE A 495ASP A 360ASN A 482 | NoneNoneNone FE A 702 ( 3.0A)ACT A 705 (-3.1A) | 1.12A | 4dcmA-5iheA:undetectable | 4dcmA-5iheA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikl | GERANYL-COACARBOXYLASE,BETA-SUBUNIT (Pseudomonasaeruginosa) |
PF01039(Carboxyl_trans) | 5 | PHE B 319ALA B 356GLY B 340GLY B 330ILE B 342 | None | 1.05A | 4dcmA-5iklB:undetectable | 4dcmA-5iklB:21.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ilb | PROTEASE DO-LIKE 2,CHLOROPLASTIC,PROTEASE DO-LIKE 9 (Arabidopsisthaliana) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | ALA A 262GLY A 266GLY A 224ILE A 263ASN A 264 | None | 1.10A | 4dcmA-5ilbA:undetectable | 4dcmA-5ilbA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jc8 | PUTATIVE SHORT-CHAINDEHYDROGENASE/REDUCTASE (Paraburkholderiaxenovorans) |
PF13561(adh_short_C2) | 6 | ALA A 29GLY A 16GLY A 18ILE A 30ASP A 45ASN A 26 | None | 1.47A | 4dcmA-5jc8A:7.9 | 4dcmA-5jc8A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jsy | PERIPLASMIC [NIFESE]HYDROGENASE, SMALLSUBUNIT (Desulfovibriovulgaris) |
PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 5 | ALA A 117GLY A 197ILE A 156ASP A 194PRO A 271 | None | 1.13A | 4dcmA-5jsyA:undetectable | 4dcmA-5jsyA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kin | TRYPTOPHAN SYNTHASEBETA CHAIN (Streptococcuspneumoniae) |
PF00291(PALP) | 5 | ALA B 112GLY B 139GLY B 115ILE B 136ASP B 142 | None | 1.12A | 4dcmA-5kinB:undetectable | 4dcmA-5kinB:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m5j | THIOREDOXINREDUCTASE (Giardiaintestinalis) |
PF07992(Pyr_redox_2) | 5 | GLY A 282GLY A 115ILE A 112ASP A 283PRO A 16 | FAD A1001 (-3.3A)FAD A1001 (-3.3A)NoneFAD A1001 (-3.0A)FAD A1001 (-3.9A) | 1.08A | 4dcmA-5m5jA:2.6 | 4dcmA-5m5jA:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tch | TRYPTOPHAN SYNTHASEBETA CHAIN (Mycobacteriumtuberculosis) |
PF00291(PALP) | 5 | ALA B 122GLY B 149GLY B 125ILE B 146ASP B 152 | NoneNoneMLI B 501 (-3.5A)NoneNone | 1.11A | 4dcmA-5tchB:undetectable | 4dcmA-5tchB:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u25 | DIHYDROLIPOAMIDEDEHYDROGENASE (E3COMPONENT OFPYRUVATE AND2-OXOGLUTARATEDEHYDROGENASECOMPLEXES) (Neisseriagonorrhoeae) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 434GLY A 268ILE A 265ASP A 435PRO A 127 | FAD A 601 (-3.2A)FAD A 601 (-3.4A)NoneFAD A 601 (-2.9A)FAD A 601 (-3.9A) | 1.15A | 4dcmA-5u25A:4.0 | 4dcmA-5u25A:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4t | PUTATIVE GENTAMICINMETHYLTRANSFERASE (Micromonosporaechinospora) |
no annotation | 7 | ALA A 112ASP A 129GLY A 131GLY A 133ASP A 152ASN A 194PRO A 196 | SAH A 414 ( 4.4A)SAH A 414 ( 3.7A)SAH A 414 (-3.0A)SAH A 414 (-2.8A)SAH A 414 (-2.1A)TRS A 415 ( 2.3A)SAH A 414 ( 3.2A) | 0.61A | 4dcmA-5u4tA:14.7 | 4dcmA-5u4tA:25.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u63 | THIOREDOXINREDUCTASE (Haemophilusinfluenzae) |
PF07992(Pyr_redox_2) | 5 | GLY A 285GLY A 114ILE A 111ASP A 286PRO A 16 | FAD A 401 (-3.1A)FAD A 401 (-3.2A)NoneFAD A 401 (-2.9A)FAD A 401 (-3.7A) | 1.15A | 4dcmA-5u63A:2.7 | 4dcmA-5u63A:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ufm | METHYLTRANSFERASEDOMAIN PROTEIN (Burkholderiathailandensis) |
no annotation | 5 | ASP A 72GLY A 74GLY A 76ASP A 95ASN A 135 | NoneSAH A 301 (-3.6A)SAH A 301 (-3.6A)SAH A 301 (-2.7A)SAH A 301 (-3.9A) | 0.78A | 4dcmA-5ufmA:14.3 | 4dcmA-5ufmA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v72 | NADPH-DEPENDENTGLYOXYLATE/HYDROXYPYRUVATE REDUCTASE (Sinorhizobiummeliloti) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | ALA A 104GLY A 149GLY A 154ILE A 198PRO A 202 | None | 1.15A | 4dcmA-5v72A:7.1 | 4dcmA-5v72A:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vj7 | OXIDOREDUCTASE (Pyrococcusfuriosus) |
PF07992(Pyr_redox_2)PF14691(Fer4_20) | 5 | GLY A 444GLY A 248ILE A 245ASP A 445PRO A 164 | FAD A 503 (-3.4A)FAD A 503 (-3.1A)NoneFAD A 503 (-2.0A)FAD A 503 (-3.3A) | 1.15A | 4dcmA-5vj7A:3.3 | 4dcmA-5vj7A:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wy0 | SMALL RNA2'-O-METHYLTRANSFERASE (Homo sapiens) |
no annotation | 5 | ASP A 23GLY A 25GLY A 27ILE A 101ASP A 48 | SAM A 800 ( 4.5A)SAM A 800 (-3.6A)SAM A 800 (-3.5A)SAM A 800 (-4.3A)SAM A 800 (-2.8A) | 0.99A | 4dcmA-5wy0A:9.3 | 4dcmA-5wy0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x2v | L-METHIONINEGAMMA-LYASE (Pseudomonasputida) |
PF01053(Cys_Met_Meta_PP) | 5 | ALA A 221ASP A 218GLY A 217GLY A 215ILE A 219 | NoneNoneNoneLLP A 211 ( 3.6A)None | 1.13A | 4dcmA-5x2vA:undetectable | 4dcmA-5x2vA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6esl | BACTERIAL LEUCYLAMINOPEPTIDASE (Legionellapneumophila) |
no annotation | 5 | PHE A 268ALA A 218GLY A 211ASP A 208GLU A 241 | NoneNoneNoneNone ZN A 402 ( 4.2A) | 1.07A | 4dcmA-6eslA:undetectable | 4dcmA-6eslA:undetectable |