SIMILAR PATTERNS OF AMINO ACIDS FOR 4DCM_A_SAMA401

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1bhy	P64K (Neisseria meningitidis)	PF02852 (Pyr_redox_dim) PF07992 (Pyr_redox_2)	5	GLY A 439 GLY A 273 ILE A 270 ASP A 440 PRO A 132	FAD  A 600 (-3.3A) FAD  A 600 (-3.3A) None FAD  A 600 (-2.7A) FAD  A 600 (-3.4A)	1.15A	4dcmA-1bhyA: 3.7	4dcmA-1bhyA: 22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1dus	MJ0882 (Methanocaldococcus jannaschii)	PF05175 (MTS)	8	PHE A  35 ASP A  61 GLY A  63 GLY A  65 ILE A  69 ASP A  84 ASN A 129 PRO A 131	None	0.57A	4dcmA-1dusA: 14.5	4dcmA-1dusA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1g0v	PROTEINASE A (Saccharomyces cerevisiae)	PF00026 (Asp)	5	GLY A  34 GLY A 217 ILE A 214 ASP A  32 ASN A  37	None	0.90A	4dcmA-1g0vA: undetectable	4dcmA-1g0vA: 22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1h3g	CYCLOMALTODEXTRINASE (Flavobacterium sp. 92)	PF00128 (Alpha-amylase) PF09087 (Cyc-maltodext_N) PF10438 (Cyc-maltodext_C)	5	GLY A 145 GLY A 149 ILE A 112 ASP A 146 ASN A 126	CA  A 700 ( 4.9A) None None CA  A 700 (-3.2A) None	1.08A	4dcmA-1h3gA: undetectable	4dcmA-1h3gA: 21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1h7w	DIHYDROPYRIMIDINE DEHYDROGENASE (Sus scrofa)	PF01180 (DHO_dh) PF07992 (Pyr_redox_2) PF14691 (Fer4_20) PF14697 (Fer4_21)	5	GLY A 480 GLY A 284 ILE A 281 ASP A 481 PRO A 197	FAD  A1031 (-3.4A) FAD  A1031 (-3.6A) None FAD  A1031 (-3.0A) FAD  A1031 (-3.7A)	1.10A	4dcmA-1h7wA: 3.2	4dcmA-1h7wA: 15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1jsc	ACETOHYDROXY-ACID SYNTHASE (Saccharomyces cerevisiae)	PF00205 (TPP_enzyme_M) PF02775 (TPP_enzyme_C) PF02776 (TPP_enzyme_N)	5	ALA A 504 GLY A 549 ILE A 547 ASP A 550 GLU A 578	None TPP  A 700 (-3.6A) None MG  A 699 ( 2.8A) None	1.03A	4dcmA-1jscA: 3.7	4dcmA-1jscA: 20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1lpf	DIHYDROLIPOAMIDE DEHYDROGENASE (Pseudomonas fluorescens)	PF02852 (Pyr_redox_dim) PF07992 (Pyr_redox_2)	5	GLY A 317 GLY A 151 ILE A 148 ASP A 318 PRO A  13	FAD  A 480 (-3.4A) FAD  A 480 (-3.4A) None FAD  A 480 (-2.9A) FAD  A 480 (-3.5A)	1.10A	4dcmA-1lpfA: 3.8	4dcmA-1lpfA: 22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ne2	HYPOTHETICAL PROTEIN TA1320 (Thermoplasma acidophilum)	PF06325 (PrmA)	5	ASP A  54 GLY A  56 GLY A  58 ASN A 114 PRO A 116	None	0.78A	4dcmA-1ne2A: 13.6	4dcmA-1ne2A: 19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ne2	HYPOTHETICAL PROTEIN TA1320 (Thermoplasma acidophilum)	PF06325 (PrmA)	5	ASP A  54 GLY A  56 GLY A  58 ASP A  78 ASN A 114	None	0.43A	4dcmA-1ne2A: 13.6	4dcmA-1ne2A: 19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	PF01555 (N6_N4_Mtase)	5	ASP A 248 GLY A 252 ILE A  63 ASP A 271 PRO A  67	None SAM  A 401 (-3.3A) None SAM  A 401 (-2.9A) SAM  A 401 (-4.3A)	0.86A	4dcmA-1nw5A: 4.3	4dcmA-1nw5A: 21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ofe	FERREDOXIN-DEPENDENT GLUTAMATE SYNTHASE 2 (Synechocystis sp. PCC 6803)	PF00310 (GATase_2) PF01493 (GXGXG) PF01645 (Glu_synthase) PF04898 (Glu_syn_central)	5	PHE A1383 ALA A1375 GLY A1361 GLY A1380 ILE A1359	None	1.09A	4dcmA-1ofeA: undetectable	4dcmA-1ofeA: 14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ri0	HEPATOMA-DERIVED GROWTH FACTOR (Homo sapiens)	PF00855 (PWWP)	5	PHE A  49 ILE A  30 GLU A  88 ASN A  91 PRO A  27	None	1.08A	4dcmA-1ri0A: undetectable	4dcmA-1ri0A: 13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1sg9	HEMK PROTEIN (Thermotoga maritima)	PF05175 (MTS)	8	PHE A 100 ASP A 127 GLY A 129 GLY A 131 ILE A 135 ASP A 151 ASN A 197 PRO A 199	SAM  A 301 ( 3.4A) SAM  A 301 ( 4.9A) SAM  A 301 (-3.3A) SAM  A 301 ( 3.8A) SAM  A 301 (-4.8A) SAM  A 301 (-2.9A) GLN  A 400 ( 3.1A) SAM  A 301 ( 4.6A)	0.57A	4dcmA-1sg9A: 17.2	4dcmA-1sg9A: 22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1tdf	THIOREDOXIN REDUCTASE (Escherichia coli)	PF07992 (Pyr_redox_2)	5	GLY A 285 GLY A 113 ILE A 110 ASP A 286 PRO A  15	FAD  A 500 (-3.1A) FAD  A 500 (-3.5A) None FAD  A 500 (-2.0A) FAD  A 500 (-3.6A)	1.10A	4dcmA-1tdfA: 2.7	4dcmA-1tdfA: 23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1u3d	CRYPTOCHROME 1 APOPROTEIN (Arabidopsis thaliana)	PF00875 (DNA_photolyase) PF03441 (FAD_binding_7)	5	PHE A  18 ALA A  29 ASP A 139 GLY A 257 ASN A  27	None	1.00A	4dcmA-1u3dA: undetectable	4dcmA-1u3dA: 20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1wdw	TRYPTOPHAN SYNTHASE BETA CHAIN 1 (Pyrococcus furiosus)	PF00291 (PALP)	5	ALA B 103 GLY B 130 GLY B 106 ILE B 127 ASP B 133	None	1.13A	4dcmA-1wdwB: undetectable	4dcmA-1wdwB: 24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1wy7	HYPOTHETICAL PROTEIN PH1948 (Pyrococcus horikoshii)	PF05175 (MTS)	5	ASP A  55 GLY A  57 GLY A  59 ASN A 119 PRO A 121	SAH  A1001 ( 4.5A) SAH  A1001 (-3.4A) SAH  A1001 (-3.3A) SAH  A1001 (-4.6A) None	0.48A	4dcmA-1wy7A: 16.9	4dcmA-1wy7A: 22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1xnt	PROTEIN (DNA-REPAIR PROTEIN XRCC1) (Homo sapiens)	PF01834 (XRCC1_N)	5	GLY A 143 GLY A  64 ASP A  63 ASN A  23 PRO A 141	None	0.91A	4dcmA-1xntA: undetectable	4dcmA-1xntA: 17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1xzw	PURPLE ACID PHOSPHATASE (Ipomoea batatas)	PF00149 (Metallophos) PF14008 (Metallophos_C) PF16656 (Pur_ac_phosph_N)	6	GLY A  39 GLY A  33 ILE A  42 ASP A  34 GLU A  36 PRO A 118	None	1.16A	4dcmA-1xzwA: undetectable	4dcmA-1xzwA: 20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1y8t	HYPOTHETICAL PROTEIN RV0983 (Mycobacterium tuberculosis)	PF13180 (PDZ_2) PF13365 (Trypsin_2)	6	ALA A 163 GLY A 167 GLY A 121 ILE A 164 GLU A  23 ASN A 165	None	1.11A	4dcmA-1y8tA: undetectable	4dcmA-1y8tA: 26.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1yq2	BETA-GALACTOSIDASE (Arthrobacter sp. C2-2)	PF02836 (Glyco_hydro_2_C) PF02837 (Glyco_hydro_2_N) PF02929 (Bgal_small_N) PF16353 (DUF4981)	5	ASP A 882 GLY A 883 GLY A 939 ASP A 936 GLU A 934	None	1.00A	4dcmA-1yq2A: undetectable	4dcmA-1yq2A: 16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2a8x	DIHYDROLIPOYL DEHYDROGENASE (Mycobacterium tuberculosis)	PF02852 (Pyr_redox_dim) PF07992 (Pyr_redox_2)	5	GLY A 308 GLY A 143 ILE A 140 ASP A 309 PRO A  13	FAD  A 480 (-3.2A) FAD  A 480 (-3.2A) None FAD  A 480 (-2.8A) FAD  A 480 (-4.0A)	1.12A	4dcmA-2a8xA: 2.6	4dcmA-2a8xA: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2b3t	PROTEIN METHYLTRANSFERASE HEMK (Escherichia coli)	PF13847 (Methyltransf_31)	7	ASP A 115 GLY A 117 GLY A 119 ILE A 123 ASP A 140 ASN A 183 PRO A 185	None SAH  A 300 (-3.4A) SAH  A 300 (-3.5A) None SAH  A 300 (-3.1A) SAH  A 300 (-3.9A) SAH  A 300 ( 3.9A)	0.48A	4dcmA-2b3tA: 20.2	4dcmA-2b3tA: 22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2bkl	PROLYL ENDOPEPTIDASE (Myxococcus xanthus)	PF00326 (Peptidase_S9) PF02897 (Peptidase_S9_N)	5	ALA A 542 GLY A 452 GLY A 535 ILE A 529 ASN A 459	None	1.14A	4dcmA-2bklA: undetectable	4dcmA-2bklA: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2cyg	BETA-1, 3-GLUCANANSE (Musa acuminata)	PF00332 (Glyco_hydro_17)	5	ALA A 136 GLY A  98 ILE A 140 ASP A  99 ASN A 139	None	0.96A	4dcmA-2cygA: undetectable	4dcmA-2cygA: 22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2h00	METHYLTRANSFERASE 10 DOMAIN CONTAINING PROTEIN (Homo sapiens)	PF05971 (Methyltransf_10)	5	ASP A  71 GLY A  73 GLY A  75 ASN A 147 PRO A 149	SAH  A 300 ( 4.2A) SAH  A 300 (-3.1A) SAH  A 300 (-3.6A) SAH  A 300 (-3.9A) SAH  A 300 (-4.0A)	0.66A	4dcmA-2h00A: 14.4	4dcmA-2h00A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2h1r	DIMETHYLADENOSINE TRANSFERASE, PUTATIVE (Plasmodium falciparum)	PF00398 (RrnaAD)	5	GLY A  29 GLY A  31 ASP A  50 ASN A  92 PRO A  94	None	0.90A	4dcmA-2h1rA: 10.7	4dcmA-2h1rA: 21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2iht	CARBOXYETHYLARGININE SYNTHASE (Streptomyces clavuligerus)	PF00205 (TPP_enzyme_M) PF02775 (TPP_enzyme_C) PF02776 (TPP_enzyme_N)	5	ASP A 409 GLY A 462 GLY A 464 ILE A 410 GLU A 556	None TPP  A 600 (-3.4A) TPP  A 600 (-3.5A) TPP  A 600 (-4.5A) None	1.12A	4dcmA-2ihtA: undetectable	4dcmA-2ihtA: 20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2o52	RAS-RELATED PROTEIN RAB-4B (Homo sapiens)	PF00071 (Ras)	5	ALA A 152 GLY A  18 GLU A  94 ASN A  97 ASN A 121	GDP  A 601 (-3.6A) GDP  A 601 (-3.5A) None None GDP  A 601 (-3.3A)	1.09A	4dcmA-2o52A: 3.6	4dcmA-2o52A: 22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ozv	HYPOTHETICAL PROTEIN ATU0636 (Agrobacterium fabrum)	PF05175 (MTS)	5	ALA A  33 ASP A  50 GLY A  52 ASN A 130 PRO A 132	None	0.94A	4dcmA-2ozvA: 11.8	4dcmA-2ozvA: 22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2p35	TRANS-ACONITATE 2-METHYLTRANSFERASE (Agrobacterium fabrum)	PF13489 (Methyltransf_23)	5	ASP A  36 GLY A  38 GLY A  40 ASP A  61 ASN A  99	SAH  A 301 ( 4.4A) SAH  A 301 (-3.6A) SAH  A 301 (-3.3A) SAH  A 301 (-2.7A) SAH  A 301 (-3.8A)	0.93A	4dcmA-2p35A: 11.9	4dcmA-2p35A: 24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2pjd	RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE C (Escherichia coli)	PF05175 (MTS) PF08468 (MTS_N)	7	ASP A 202 GLY A 204 GLY A 206 ASP A 227 ASN A 253 ASN A 268 PRO A 270	None	0.71A	4dcmA-2pjdA: 31.3	4dcmA-2pjdA: 27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2q0l	THIOREDOXIN REDUCTASE (Helicobacter pylori)	PF07992 (Pyr_redox_2)	5	GLY A 280 GLY A 111 ILE A 108 ASP A 281 PRO A  11	FAD  A 400 (-3.3A) FAD  A 400 (-3.3A) None FAD  A 400 (-2.7A) FAD  A 400 (-3.4A)	1.05A	4dcmA-2q0lA: 3.4	4dcmA-2q0lA: 23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ru4	ARMADILLO REPEAT PROTEIN, N-TERMINAL FRAGMENT, YIIM2 (synthetic construct)	PF00514 (Arm)	5	ALA A 108 GLY A  74 ILE A 112 GLU A  34 ASN A 111	None	1.10A	4dcmA-2ru4A: undetectable	4dcmA-2ru4A: 14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2vdc	GLUTAMATE SYNTHASE [NADPH] LARGE CHAIN (Azospirillum brasilense)	PF00310 (GATase_2) PF01493 (GXGXG) PF01645 (Glu_synthase) PF04898 (Glu_syn_central)	5	PHE A1346 ALA A1338 GLY A1324 GLY A1343 ILE A1322	None	1.07A	4dcmA-2vdcA: undetectable	4dcmA-2vdcA: 13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2zfu	CEREBRAL PROTEIN 1 (Homo sapiens)	PF05148 (Methyltransf_8)	5	PHE A 284 ASP A 314 GLY A 316 GLY A 318 ASP A 334	SAH  A 900 (-3.7A) SAH  A 900 ( 4.6A) SAH  A 900 (-3.5A) SAH  A 900 ( 3.7A) SAH  A 900 (-2.7A)	0.68A	4dcmA-2zfuA: 12.1	4dcmA-2zfuA: 21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2zwv	PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE (Thermus thermophilus)	PF05175 (MTS)	6	PHE A 207 ASP A 239 GLY A 241 GLY A 243 ASN A 305 PRO A 307	SAH  A 376 (-3.4A) SAH  A 376 ( 4.2A) SAH  A 376 (-3.1A) SAH  A 376 (-3.4A) SAH  A 376 (-4.4A) SAH  A 376 ( 4.3A)	0.53A	4dcmA-2zwvA: 33.6	4dcmA-2zwvA: 27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3abi	PUTATIVE UNCHARACTERIZED PROTEIN PH1688 (Pyrococcus horikoshii)	PF03435 (Sacchrp_dh_NADP) PF16653 (Sacchrp_dh_C)	5	GLY A   7 GLY A   9 ILE A  15 ASP A  29 PRO A  70	NAD  A1001 ( 3.8A) NAD  A1001 (-3.7A) None NAD  A1001 (-2.9A) NAD  A1001 (-3.8A)	1.10A	4dcmA-3abiA: 5.4	4dcmA-3abiA: 21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ayf	NITRIC OXIDE REDUCTASE (Geobacillus stearothermophilus)	PF00115 (COX1)	5	GLY A 411 GLY A 407 ILE A 350 GLU A 419 ASN A 418	None	1.05A	4dcmA-3ayfA: undetectable	4dcmA-3ayfA: 17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ccf	CYCLOPROPANE-FATTY-A CYL-PHOSPHOLIPID SYNTHASE (Trichormus variabilis)	PF08241 (Methyltransf_11)	5	ASP A  44 GLY A  46 GLY A  48 ASP A  67 ASN A 105	None	0.68A	4dcmA-3ccfA: 14.6	4dcmA-3ccfA: 23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3cgg	SAM-DEPENDENT METHYLTRANSFERASE (Corynebacterium glutamicum)	PF13649 (Methyltransf_25)	5	ASP A  51 GLY A  53 GLY A  55 ILE A  59 ASP A  74	None NHE  A 195 (-3.2A) None None NHE  A 195 (-3.6A)	0.47A	4dcmA-3cggA: 12.0	4dcmA-3cggA: 21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3cjt	RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE (Thermus thermophilus)	PF06325 (PrmA)	6	PHE A  99 ASP A 126 GLY A 128 GLY A 130 ASP A 149 ASN A 191	SAH  A 258 ( 4.3A) SAH  A 258 ( 3.9A) SAH  A 258 (-3.1A) SAH  A 258 (-3.6A) SAH  A 258 (-2.8A) SAH  A 258 ( 3.8A)	0.40A	4dcmA-3cjtA: 17.7	4dcmA-3cjtA: 24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3e8s	PUTATIVE SAM DEPENDENT METHYLTRANSFERASE (Pseudomonas putida)	PF13489 (Methyltransf_23)	5	ASP A  57 GLY A  59 GLY A  61 ASP A  80 ASN A 122	SAH  A 300 ( 4.7A) SAH  A 300 (-4.2A) SAH  A 300 (-3.1A) SAH  A 300 (-2.7A) SAH  A 300 (-3.8A)	0.97A	4dcmA-3e8sA: 11.8	4dcmA-3e8sA: 23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3eka	HYALURONIDASE, PHAGE ASSOCIATED (Streptococcus pyogenes)	PF07212 (Hyaluronidase_1)	5	PHE A  49 ALA A  40 GLY A  43 ILE A  55 ASP A  44	None	1.11A	4dcmA-3ekaA: undetectable	4dcmA-3ekaA: 25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3grz	RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE (Lactobacillus delbrueckii)	PF06325 (PrmA)	5	ASP A 182 GLY A 184 GLY A 186 ASP A 206 ASN A 248	None GOL  A 322 ( 3.7A) None GOL  A 322 (-3.5A) None	0.53A	4dcmA-3grzA: 18.3	4dcmA-3grzA: 23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ijp	DIHYDRODIPICOLINATE REDUCTASE (Bartonella henselae)	PF01113 (DapB_N) PF05173 (DapB_C)	5	ALA A  44 GLY A  10 GLY A   7 ILE A  17 ASN A 157	None NAP  A 300 (-3.3A) NAP  A 300 (-3.3A) None None	1.05A	4dcmA-3ijpA: 5.2	4dcmA-3ijpA: 23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3jwi	METHYLTRANSFERASE TYPE 12 (Ruminiclostridium thermocellum)	PF08242 (Methyltransf_12)	5	ASP A  35 GLY A  37 GLY A  39 ILE A 109 ASP A  60	None	0.82A	4dcmA-3jwiA: 11.7	4dcmA-3jwiA: 21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3k0b	PREDICTED N6-ADENINE-SPECIFIC DNA METHYLASE (Listeria monocytogenes)	PF01170 (UPF0020) PF02926 (THUMP)	5	ASP A 196 GLY A 200 ILE A 204 ASP A 259 ASN A 303	None	0.91A	4dcmA-3k0bA: 14.5	4dcmA-3k0bA: 24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ldg	PUTATIVE UNCHARACTERIZED PROTEIN SMU.472 (Streptococcus mutans)	PF01170 (UPF0020) PF02926 (THUMP)	5	ASP A 200 GLY A 204 ASP A 263 ASN A 307 PRO A 309	None SAH  A 385 (-3.4A) SAH  A 385 (-2.8A) SAH  A 385 (-4.3A) SAH  A 385 (-4.2A)	0.66A	4dcmA-3ldgA: 10.7	4dcmA-3ldgA: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ldu	PUTATIVE METHYLASE (Clostridioides difficile)	PF01170 (UPF0020) PF02926 (THUMP)	5	ASP A 198 GLY A 202 ILE A 206 ASP A 261 ASN A 305	None GTP  A 383 (-2.6A) None GTP  A 383 (-3.0A) GTP  A 383 (-4.2A)	0.76A	4dcmA-3lduA: 10.5	4dcmA-3lduA: 23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ldu	PUTATIVE METHYLASE (Clostridioides difficile)	PF01170 (UPF0020) PF02926 (THUMP)	5	GLY A 202 ILE A 206 ASP A 261 ASN A 305 PRO A 307	GTP  A 383 (-2.6A) None GTP  A 383 (-3.0A) GTP  A 383 (-4.2A) GTP  A 383 (-3.7A)	0.54A	4dcmA-3lduA: 10.5	4dcmA-3lduA: 23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3lpm	PUTATIVE METHYLTRANSFERASE (Listeria monocytogenes)	PF05175 (MTS)	5	ALA A  37 ASP A  55 GLY A  59 ILE A  63 ASN A 126	None	0.62A	4dcmA-3lpmA: 20.6	4dcmA-3lpmA: 24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3pr2	TRYPTOPHAN SYNTHASE BETA CHAIN (Salmonella enterica)	PF00291 (PALP)	5	ALA B 108 GLY B 135 GLY B 111 ILE B 132 ASP B 138	None None 7MN  B   2 (-3.7A) None None	1.09A	4dcmA-3pr2B: 2.5	4dcmA-3pr2B: 22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3q87	N6 ADENINE SPECIFIC DNA METHYLASE (Encephalitozoon cuniculi)	PF05175 (MTS)	6	ASP B  29 GLY B  31 ILE B  37 ASP B  51 ASN B  85 PRO B  87	SAM  B 300 ( 4.7A) SAM  B 300 (-3.5A) None SAM  B 300 (-2.9A) SAM  B 300 (-3.9A) SAM  B 300 (-4.1A)	0.41A	4dcmA-3q87B: 12.3	4dcmA-3q87B: 21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3sm3	SAM-DEPENDENT METHYLTRANSFERASES (Methanosarcina mazei)	PF08241 (Methyltransf_11)	6	ASP A  36 GLY A  38 GLY A  40 ILE A  44 ASP A  59 ASN A  91	None	0.62A	4dcmA-3sm3A: 13.2	4dcmA-3sm3A: 24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3tma	METHYLTRANSFERASE (Thermus thermophilus)	PF01170 (UPF0020) PF02926 (THUMP)	6	ASP A 190 GLY A 194 ILE A 198 ASP A 216 ASN A 260 PRO A 262	None	0.68A	4dcmA-3tmaA: 17.1	4dcmA-3tmaA: 24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ze6	PERIPLASMIC [NIFESE] HYDROGENASE, SMALL SUBUNIT (Desulfovibrio vulgaris)	PF01058 (Oxidored_q6) PF14720 (NiFe_hyd_SSU_C)	5	ALA A 117 GLY A 197 ILE A 156 ASP A 194 PRO A 271	None	1.16A	4dcmA-3ze6A: undetectable	4dcmA-3ze6A: 20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4bms	ALCLOHOL DEHYDROGENASE/SHORT- CHAIN DEHYDROGENASE (Ralstonia sp. DSMZ 6428)	PF13561 (adh_short_C2)	5	ALA A  46 GLY A  13 GLY A  37 ILE A  35 ASN A 111	None NAP  A1250 (-3.1A) NAP  A1250 (-3.5A) None None	1.01A	4dcmA-4bmsA: 6.5	4dcmA-4bmsA: 23.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4dcm	RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE G (Escherichia coli)	PF05175 (MTS)	11	PHE A 208 ALA A 217 ASP A 234 GLY A 236 GLY A 238 ILE A 242 ASP A 259 GLU A 260 ASN A 289 ASN A 305 PRO A 307	SAM  A 401 (-3.6A) SAM  A 401 (-3.2A) SAM  A 401 ( 4.2A) SAM  A 401 (-3.5A) SAM  A 401 ( 3.7A) SAM  A 401 (-4.7A) SAM  A 401 (-2.9A) None SAM  A 401 (-4.3A) SAM  A 401 (-3.8A) SAM  A 401 (-4.0A)	0.04A	4dcmA-4dcmA: 60.9	4dcmA-4dcmA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4dcm	RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE G (Escherichia coli)	PF05175 (MTS)	6	PHE A 208 ALA A 217 GLY A 236 GLY A 238 ASN A 288 ASN A 305	SAM  A 401 (-3.6A) SAM  A 401 (-3.2A) SAM  A 401 (-3.5A) SAM  A 401 ( 3.7A) None SAM  A 401 (-3.8A)	1.28A	4dcmA-4dcmA: 60.9	4dcmA-4dcmA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4dzr	PROTEIN-(GLUTAMINE-N 5) METHYLTRANSFERASE, RELEASE FACTOR-SPECIFIC (Alicyclobacillus acidocaldarius)	PF05175 (MTS)	5	ASP A 134 GLY A 136 GLY A 138 ILE A 142 ASP A 159	None	1.11A	4dcmA-4dzrA: 10.9	4dcmA-4dzrA: 22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ep5	CROSSOVER JUNCTION ENDODEOXYRIBONUCLEAS E RUVC (Thermus thermophilus)	PF02075 (RuvC)	5	ALA A 149 GLY A  14 GLY A  16 ILE A 150 PRO A 141	None None None None GOL  A 205 (-4.2A)	1.00A	4dcmA-4ep5A: undetectable	4dcmA-4ep5A: 19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4evi	CONIFERYL ALCOHOL 9-O-METHYLTRANSFERAS E (Linum nodiflorum)	PF00891 (Methyltransf_2) PF08100 (Dimerisation)	5	ASP A 206 GLY A 208 GLY A 210 ASP A 231 ASN A 252	None SAH  A 401 (-3.6A) SAH  A 401 ( 3.8A) SAH  A 401 (-2.9A) SAH  A 401 (-3.3A)	0.46A	4dcmA-4eviA: 11.0	4dcmA-4eviA: 23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4gc5	DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL (Mus musculus)	PF00398 (RrnaAD)	5	GLY A  63 GLY A  65 ILE A  69 ASN A 141 PRO A 143	ACT  A 402 (-3.4A) None None None ACT  A 402 ( 4.9A)	0.67A	4dcmA-4gc5A: 11.7	4dcmA-4gc5A: 24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4hkt	INOSITOL 2-DEHYDROGENASE (Sinorhizobium meliloti)	PF01408 (GFO_IDH_MocA) PF02894 (GFO_IDH_MocA_C)	5	ALA A  42 ASP A  34 GLY A   9 GLY A  11 GLU A  92	None	1.04A	4dcmA-4hktA: 6.6	4dcmA-4hktA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4jnq	THIOREDOXIN REDUCTASE (Brucella melitensis)	PF07992 (Pyr_redox_2)	5	GLY A 285 GLY A 114 ILE A 111 ASP A 286 PRO A  15	FDA  A 401 (-3.4A) FDA  A 401 (-3.3A) None FDA  A 401 (-3.0A) FDA  A 401 (-3.6A)	1.13A	4dcmA-4jnqA: 2.6	4dcmA-4jnqA: 21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4jq9	DIHYDROLIPOYL DEHYDROGENASE (Escherichia coli)	PF02852 (Pyr_redox_dim) PF07992 (Pyr_redox_2)	5	GLY A 312 GLY A 146 ILE A 143 ASP A 313 PRO A  16	FAD  A 512 (-3.4A) FAD  A 512 (-3.4A) None FAD  A 512 (-3.0A) FAD  A 512 (-3.9A)	1.14A	4dcmA-4jq9A: 3.7	4dcmA-4jq9A: 21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4krg	PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE 1 (Haemonchus contortus)	PF08241 (Methyltransf_11)	5	ASP A  57 GLY A  59 GLY A  61 ASP A  80 ASN A 122	None SAH  A 502 (-3.6A) SAH  A 502 (-3.4A) SAH  A 502 (-2.5A) SAH  A 502 (-3.9A)	0.79A	4dcmA-4krgA: 13.7	4dcmA-4krgA: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4obw	2-METHOXY-6-POLYPREN YL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL (Saccharomyces cerevisiae)	PF01209 (Ubie_methyltran)	5	ASP A 117 GLY A 121 ILE A 125 ASP A 148 ASN A 179	None None None SAM  A 602 (-2.9A) SAM  A 602 (-3.7A)	0.78A	4dcmA-4obwA: 18.3	4dcmA-4obwA: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4rf3	NADPH DEPENDENT R-SPECIFIC ALCOHOL DEHYDROGENASE (Lactobacillus kefiri)	PF13561 (adh_short_C2)	5	ALA A  47 GLY A  14 GLY A  38 ILE A  36 ASN A 114	None	0.99A	4dcmA-4rf3A: 5.3	4dcmA-4rf3A: 22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ynn	PROTEASE DO (Legionella pneumophila)	PF13180 (PDZ_2) PF13365 (Trypsin_2)	5	ALA A 184 GLY A 188 GLY A 143 ILE A 185 ASN A 186	None	1.09A	4dcmA-4ynnA: undetectable	4dcmA-4ynnA: 22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4z8z	UNCHARACTERIZED PROTEIN (Ruminiclostridium thermocellum)	no annotation	5	PHE A 131 ALA A 155 GLY A 144 ILE A 148 GLU A 128	None	1.13A	4dcmA-4z8zA: undetectable	4dcmA-4z8zA: 22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4zgz	ANTIZYME INHIBITOR 1 (Homo sapiens)	PF00278 (Orn_DAP_Arg_deC) PF02784 (Orn_Arg_deC_N)	5	ALA A  39 GLY A 355 GLY A 319 ASP A 362 ASN A 317	None	1.12A	4dcmA-4zgzA: undetectable	4dcmA-4zgzA: 22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4zn0	THIOREDOXIN REDUCTASE (Methanosarcina mazei)	PF07992 (Pyr_redox_2)	5	GLY A 276 GLY A 111 ILE A 108 ASP A 277 PRO A  14	None	1.08A	4dcmA-4zn0A: 3.6	4dcmA-4zn0A: 23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5afu	DYNACTIN (Sus scrofa)	PF00022 (Actin)	5	ALA J 354 GLY J 308 GLY J 142 ILE J 306 GLU J 208	None ADP  J 800 ( 3.2A) ADP  J 800 ( 3.1A) None ADP  J 800 ( 4.6A)	1.11A	4dcmA-5afuJ: undetectable	4dcmA-5afuJ: 23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5bp9	PUTATIVE METHYLTRANSFERASE PROTEIN (Bacteroides fragilis)	PF13489 (Methyltransf_23)	5	ASP A  86 GLY A  88 GLY A  90 ASP A 109 ASN A 130	None SAH  A 303 (-3.3A) SAH  A 303 ( 3.7A) SAH  A 303 (-2.7A) SAH  A 303 (-3.0A)	0.56A	4dcmA-5bp9A: 10.8	4dcmA-5bp9A: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5bs5	3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSF ERASE (Acinetobacter baumannii)	PF00275 (EPSP_synthase)	5	PHE A 698 GLY A 724 GLY A 700 ILE A 317 PRO A 696	None	1.09A	4dcmA-5bs5A: undetectable	4dcmA-5bs5A: 21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5bwa	ORNITHINE DECARBOXYLASE (Homo sapiens)	PF00278 (Orn_DAP_Arg_deC) PF02784 (Orn_Arg_deC_N)	5	ALA A  39 GLY A 357 GLY A 321 ASP A 364 ASN A 319	None	1.12A	4dcmA-5bwaA: undetectable	4dcmA-5bwaA: 22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5dly	PLANTAZOLICIN METHYLTRANSFERASE BAML (Bacillus velezensis)	PF13847 (Methyltransf_31)	5	ASP A  66 GLY A  68 GLY A  70 ASP A  91 ASN A 113	SAH  A 301 ( 4.7A) SAH  A 301 (-3.6A) SAH  A 301 ( 3.7A) SAH  A 301 (-2.8A) SAH  A 301 (-3.8A)	0.46A	4dcmA-5dlyA: 11.5	4dcmA-5dlyA: 21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5e1b	N-TERMINAL XAA-PRO-LYS N-METHYLTRANSFERASE 1 (Homo sapiens)	PF05891 (Methyltransf_PK)	5	ASP A  67 GLY A  69 GLY A  71 ILE A  75 ASP A  91	None SAH  A 301 (-3.9A) SAH  A 301 (-3.1A) None SAH  A 301 (-2.7A)	0.43A	4dcmA-5e1bA: 13.1	4dcmA-5e1bA: 24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5evj	ARSENITE METHYLTRANSFERASE (Chlamydomonas reinhardtii)	PF13847 (Methyltransf_31)	5	ASP A  89 GLY A  91 GLY A  93 ASP A 115 ASN A 169	None	0.78A	4dcmA-5evjA: 14.2	4dcmA-5evjA: 24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5fad	RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE, PUTATIVE (Sulfolobus islandicus)	PF13847 (Methyltransf_31)	5	ASP A  34 GLY A  36 GLY A  38 ILE A  42 ASN A  87	SAH  A 201 (-2.9A) SAH  A 201 (-3.0A) SAH  A 201 (-3.5A) None SAH  A 201 (-3.7A)	0.95A	4dcmA-5fadA: 11.8	4dcmA-5fadA: 17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5fji	BETA-GLUCOSIDASE (Aspergillus fumigatus)	PF00933 (Glyco_hydro_3) PF01915 (Glyco_hydro_3_C) PF14310 (Fn3-like)	5	ALA A 506 GLY A 573 ILE A 549 ASN A 581 ASN A 505	None None None EDO  A1867 (-4.4A) None	1.14A	4dcmA-5fjiA: undetectable	4dcmA-5fjiA: 17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ihe	DNA POLYMERASE II SMALL SUBUNIT (Pyrococcus abyssi)	PF00149 (Metallophos)	5	GLY A 403 GLY A 559 ILE A 495 ASP A 360 ASN A 482	None None None FE  A 702 ( 3.0A) ACT  A 705 (-3.1A)	1.12A	4dcmA-5iheA: undetectable	4dcmA-5iheA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ikl	GERANYL-COA CARBOXYLASE, BETA-SUBUNIT (Pseudomonas aeruginosa)	PF01039 (Carboxyl_trans)	5	PHE B 319 ALA B 356 GLY B 340 GLY B 330 ILE B 342	None	1.05A	4dcmA-5iklB: undetectable	4dcmA-5iklB: 21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ilb	PROTEASE DO-LIKE 2, CHLOROPLASTIC,PROTEA SE DO-LIKE 9 (Arabidopsis thaliana)	PF13180 (PDZ_2) PF13365 (Trypsin_2)	5	ALA A 262 GLY A 266 GLY A 224 ILE A 263 ASN A 264	None	1.10A	4dcmA-5ilbA: undetectable	4dcmA-5ilbA: 21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5jc8	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	PF13561 (adh_short_C2)	6	ALA A  29 GLY A  16 GLY A  18 ILE A  30 ASP A  45 ASN A  26	None	1.47A	4dcmA-5jc8A: 7.9	4dcmA-5jc8A: 20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5jsy	PERIPLASMIC [NIFESE] HYDROGENASE, SMALL SUBUNIT (Desulfovibrio vulgaris)	PF01058 (Oxidored_q6) PF14720 (NiFe_hyd_SSU_C)	5	ALA A 117 GLY A 197 ILE A 156 ASP A 194 PRO A 271	None	1.13A	4dcmA-5jsyA: undetectable	4dcmA-5jsyA: 22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5kin	TRYPTOPHAN SYNTHASE BETA CHAIN (Streptococcus pneumoniae)	PF00291 (PALP)	5	ALA B 112 GLY B 139 GLY B 115 ILE B 136 ASP B 142	None	1.12A	4dcmA-5kinB: undetectable	4dcmA-5kinB: 24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5m5j	THIOREDOXIN REDUCTASE (Giardia intestinalis)	PF07992 (Pyr_redox_2)	5	GLY A 282 GLY A 115 ILE A 112 ASP A 283 PRO A  16	FAD  A1001 (-3.3A) FAD  A1001 (-3.3A) None FAD  A1001 (-3.0A) FAD  A1001 (-3.9A)	1.08A	4dcmA-5m5jA: 2.6	4dcmA-5m5jA: 21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5tch	TRYPTOPHAN SYNTHASE BETA CHAIN (Mycobacterium tuberculosis)	PF00291 (PALP)	5	ALA B 122 GLY B 149 GLY B 125 ILE B 146 ASP B 152	None None MLI  B 501 (-3.5A) None None	1.11A	4dcmA-5tchB: undetectable	4dcmA-5tchB: 24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5u25	DIHYDROLIPOAMIDE DEHYDROGENASE (E3 COMPONENT OF PYRUVATE AND 2-OXOGLUTARATE DEHYDROGENASE COMPLEXES) (Neisseria gonorrhoeae)	PF02852 (Pyr_redox_dim) PF07992 (Pyr_redox_2)	5	GLY A 434 GLY A 268 ILE A 265 ASP A 435 PRO A 127	FAD  A 601 (-3.2A) FAD  A 601 (-3.4A) None FAD  A 601 (-2.9A) FAD  A 601 (-3.9A)	1.15A	4dcmA-5u25A: 4.0	4dcmA-5u25A: 20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5u4t	PUTATIVE GENTAMICIN METHYLTRANSFERASE (Micromonospora echinospora)	no annotation	7	ALA A 112 ASP A 129 GLY A 131 GLY A 133 ASP A 152 ASN A 194 PRO A 196	SAH  A 414 ( 4.4A) SAH  A 414 ( 3.7A) SAH  A 414 (-3.0A) SAH  A 414 (-2.8A) SAH  A 414 (-2.1A) TRS  A 415 ( 2.3A) SAH  A 414 ( 3.2A)	0.61A	4dcmA-5u4tA: 14.7	4dcmA-5u4tA: 25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5u63	THIOREDOXIN REDUCTASE (Haemophilus influenzae)	PF07992 (Pyr_redox_2)	5	GLY A 285 GLY A 114 ILE A 111 ASP A 286 PRO A  16	FAD  A 401 (-3.1A) FAD  A 401 (-3.2A) None FAD  A 401 (-2.9A) FAD  A 401 (-3.7A)	1.15A	4dcmA-5u63A: 2.7	4dcmA-5u63A: 22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ufm	METHYLTRANSFERASE DOMAIN PROTEIN (Burkholderia thailandensis)	no annotation	5	ASP A  72 GLY A  74 GLY A  76 ASP A  95 ASN A 135	None SAH  A 301 (-3.6A) SAH  A 301 (-3.6A) SAH  A 301 (-2.7A) SAH  A 301 (-3.9A)	0.78A	4dcmA-5ufmA: 14.3	4dcmA-5ufmA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5v72	NADPH-DEPENDENT GLYOXYLATE/HYDROXYPY RUVATE REDUCTASE (Sinorhizobium meliloti)	PF00389 (2-Hacid_dh) PF02826 (2-Hacid_dh_C)	5	ALA A 104 GLY A 149 GLY A 154 ILE A 198 PRO A 202	None	1.15A	4dcmA-5v72A: 7.1	4dcmA-5v72A: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5vj7	OXIDOREDUCTASE (Pyrococcus furiosus)	PF07992 (Pyr_redox_2) PF14691 (Fer4_20)	5	GLY A 444 GLY A 248 ILE A 245 ASP A 445 PRO A 164	FAD  A 503 (-3.4A) FAD  A 503 (-3.1A) None FAD  A 503 (-2.0A) FAD  A 503 (-3.3A)	1.15A	4dcmA-5vj7A: 3.3	4dcmA-5vj7A: 22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5wy0	SMALL RNA 2'-O-METHYLTRANSFERA SE (Homo sapiens)	no annotation	5	ASP A  23 GLY A  25 GLY A  27 ILE A 101 ASP A  48	SAM  A 800 ( 4.5A) SAM  A 800 (-3.6A) SAM  A 800 (-3.5A) SAM  A 800 (-4.3A) SAM  A 800 (-2.8A)	0.99A	4dcmA-5wy0A: 9.3	4dcmA-5wy0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5x2v	L-METHIONINE GAMMA-LYASE (Pseudomonas putida)	PF01053 (Cys_Met_Meta_PP)	5	ALA A 221 ASP A 218 GLY A 217 GLY A 215 ILE A 219	None None None LLP  A 211 ( 3.6A) None	1.13A	4dcmA-5x2vA: undetectable	4dcmA-5x2vA: 22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6esl	BACTERIAL LEUCYL AMINOPEPTIDASE (Legionella pneumophila)	no annotation	5	PHE A 268 ALA A 218 GLY A 211 ASP A 208 GLU A 241	None None None None ZN  A 402 ( 4.2A)	1.07A	4dcmA-6eslA: undetectable	4dcmA-6eslA: undetectable