SIMILAR PATTERNS OF AMINO ACIDS FOR 4DC3_A_ADNA401_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1dgm | ADENOSINE KINASE (Toxoplasmagondii) |
PF00294(PfkB) | 9 | ASN A 20ASP A 24LEU A 46GLY A 68ASN A 73THR A 140LEU A 142GLY A 315ASP A 318 | ADN A 375 ( 3.8A)ADN A 375 (-2.9A)NoneADN A 375 ( 4.5A)ADN A 375 ( 4.9A)ADN A 375 ( 4.9A)NoneACY A 370 (-3.1A)ADN A 375 ( 3.1A) | 0.82A | 4dc3A-1dgmA:40.2 | 4dc3A-1dgmA:31.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ek2 | EPOXIDE HYDROLASE (Mus musculus) |
PF00561(Abhydrolase_1)PF13419(HAD_2) | 5 | LEU A 462GLY A 425ALA A 421VAL A 390LEU A 395 | None | 1.02A | 4dc3A-1ek2A:3.4 | 4dc3A-1ek2A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f2h | TUMOR NECROSISFACTOR RECEPTOR TYPE1 ASSOCIATED DEATHDOMAIN PROTEIN (Homo sapiens) |
PF09034(TRADD_N) | 5 | LEU A 125GLY A 84ALA A 89LEU A 129GLY A 54 | None | 0.91A | 4dc3A-1f2hA:undetectable | 4dc3A-1f2hA:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i74 | PROBABLEMANGANESE-DEPENDENTINORGANICPYROPHOSPHATASE (Streptococcusmutans) |
PF01368(DHH)PF02833(DHHA2) | 5 | ASP A 162GLY A 117ALA A 119GLY A 145ASP A 14 | NoneNone MN A 402 ( 4.9A)None MN A 402 (-3.3A) | 0.88A | 4dc3A-1i74A:undetectable | 4dc3A-1i74A:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iyn | CHLOROPLASTICASCORBATE PEROXIDASE (Nicotianatabacum) |
PF00141(peroxidase) | 5 | LEU A 159GLY A 50ALA A 52ASN A 53LEU A 151 | HEM A 296 (-4.0A)NoneNone NA A 298 (-2.9A)None | 0.94A | 4dc3A-1iynA:undetectable | 4dc3A-1iynA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3b | ATP-DEPENDENTPHOSPHOENOLPYRUVATECARBOXYKINASE (Thermusthermophilus) |
PF01293(PEPCK_ATP) | 5 | LEU A 441ALA A 347THR A 444LEU A 241GLY A 351 | None | 1.03A | 4dc3A-1j3bA:undetectable | 4dc3A-1j3bA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jp4 | 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE (Rattusnorvegicus) |
PF00459(Inositol_P) | 5 | ASP A 120LEU A 270GLY A 220THR A 248LEU A 262 | MG A 701 (-3.1A)NoneAMP A 601 (-3.5A)NoneNone | 0.92A | 4dc3A-1jp4A:undetectable | 4dc3A-1jp4A:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k20 | MANGANESE-DEPENDENTINORGANICPYROPHOSPHATASE (Streptococcusgordonii) |
PF01368(DHH)PF02833(DHHA2) | 5 | ASP A 164GLY A 119ALA A 121GLY A 147ASP A 15 | NoneNone MN A 702 ( 4.6A)None MN A 702 (-3.1A) | 0.91A | 4dc3A-1k20A:undetectable | 4dc3A-1k20A:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kol | FORMALDEHYDEDEHYDROGENASE (Pseudomonasputida) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 198ALA A 192LEU A 223GLY A 263ASP A 260 | NoneNAD A1403 ( 4.1A)NoneNAD A1403 ( 4.0A)None | 1.00A | 4dc3A-1kolA:4.9 | 4dc3A-1kolA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ly7 | FRATAXIN (Homo sapiens) |
PF01491(Frataxin_Cyay) | 5 | LEU A 103GLY A 207THR A 102LEU A 106GLY A 170 | None | 0.99A | 4dc3A-1ly7A:undetectable | 4dc3A-1ly7A:13.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p8r | ARGINASE 1 (Rattusnorvegicus) |
PF00491(Arginase) | 5 | LEU A 219GLY A 178MET A 212THR A 215GLY A 257 | None | 0.98A | 4dc3A-1p8rA:2.4 | 4dc3A-1p8rA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tz6 | PUTATIVE SUGARKINASE (Salmonellaenterica) |
PF00294(PfkB) | 6 | ASP A 16GLY A 30ALA A 32ASN A 35GLY A 249ASP A 252 | AIS A 402 (-2.5A)AIS A 402 ( 4.2A)AIS A 402 ( 4.2A)AIS A 402 (-3.9A)AIS A 402 ( 4.5A)AIS A 402 (-3.0A) | 0.48A | 4dc3A-1tz6A:29.7 | 4dc3A-1tz6A:27.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uz5 | 402AA LONGHYPOTHETICALMOLYBDOPTERINBIOSYNTHESIS MOEAPROTEIN (Pyrococcushorikoshii) |
PF00994(MoCF_biosynth)PF03453(MoeA_N)PF03454(MoeA_C) | 5 | LEU A 300GLY A 223ALA A 215ASN A 217VAL A 185 | None | 0.96A | 4dc3A-1uz5A:undetectable | 4dc3A-1uz5A:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v19 | 2-KETO-3-DEOXYGLUCONATE KINASE (Thermusthermophilus) |
PF00294(PfkB) | 6 | LEU A 170ALA A 35ASN A 38LEU A 138GLY A 248ASP A 251 | None | 1.07A | 4dc3A-1v19A:31.4 | 4dc3A-1v19A:24.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v19 | 2-KETO-3-DEOXYGLUCONATE KINASE (Thermusthermophilus) |
PF00294(PfkB) | 6 | LEU A 170GLY A 33ALA A 35ASN A 38GLY A 248ASP A 251 | None | 0.93A | 4dc3A-1v19A:31.4 | 4dc3A-1v19A:24.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2abq | FRUCTOSE 1-PHOSPHATEKINASE (Bacillushalodurans) |
PF00294(PfkB) | 6 | ASN A 8ASP A 12GLY A 36ASN A 41GLY A 246ASP A 249 | None | 1.12A | 4dc3A-2abqA:25.2 | 4dc3A-2abqA:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2afb | 2-KETO-3-DEOXYGLUCONATE KINASE (Thermotogamaritima) |
PF00294(PfkB) | 7 | LEU A 171GLY A 32ALA A 34ASN A 37LEU A 139GLY A 277ASP A 280 | None | 1.07A | 4dc3A-2afbA:28.9 | 4dc3A-2afbA:25.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ajr | SUGAR KINASE, PFKBFAMILY (Thermotogamaritima) |
PF00294(PfkB) | 6 | ASN A 8ASP A 12GLY A 39ASN A 44GLY A 258ASP A 261 | NoneACT A 321 (-3.1A)ACT A 321 ( 4.3A)ACT A 321 (-3.9A)NoneNone | 1.00A | 4dc3A-2ajrA:24.0 | 4dc3A-2ajrA:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bq8 | TARTRATE-RESISTANTACID PHOSPHATASETYPE 5 (Homo sapiens) |
PF00149(Metallophos) | 5 | LEU X 139GLY X 218THR X 136LEU X 134GLY X 194 | None | 1.03A | 4dc3A-2bq8X:undetectable | 4dc3A-2bq8X:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c49 | SUGAR KINASE MJ0406 (Methanocaldococcusjannaschii) |
PF00294(PfkB) | 6 | ASP A 17ALA A 44ASN A 47THR A 111GLY A 244ASP A 247 | ADN A1301 (-2.8A)ADN A1301 ( 4.1A)ADN A1301 (-3.4A)ADN A1301 (-3.1A)NoneADN A1301 (-2.9A) | 1.18A | 4dc3A-2c49A:27.3 | 4dc3A-2c49A:25.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c49 | SUGAR KINASE MJ0406 (Methanocaldococcusjannaschii) |
PF00294(PfkB) | 6 | ASP A 17GLY A 42ALA A 44ASN A 47GLY A 244ASP A 247 | ADN A1301 (-2.8A)ADN A1301 (-3.4A)ADN A1301 ( 4.1A)ADN A1301 (-3.4A)NoneADN A1301 (-2.9A) | 0.73A | 4dc3A-2c49A:27.3 | 4dc3A-2c49A:25.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ddu | REELIN (Mus musculus) |
no annotation | 5 | LEU A1459GLY A1488LEU A1484GLY A1364ASP A1365 | None | 1.00A | 4dc3A-2dduA:undetectable | 4dc3A-2dduA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dw6 | BLL6730 PROTEIN (Bradyrhizobiumjaponicum) |
PF13378(MR_MLE_C) | 5 | LEU A 73ALA A 119VAL A 93MET A 97GLY A 114 | None | 0.95A | 4dc3A-2dw6A:undetectable | 4dc3A-2dw6A:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2enx | MANGANESE-DEPENDENTINORGANICPYROPHOSPHATASE (Streptococcusagalactiae) |
PF01368(DHH)PF02833(DHHA2) | 5 | ASP A 164GLY A 119ALA A 121GLY A 147ASP A 15 | NoneNone MN A 402 ( 4.9A)None MN A 402 (-3.2A) | 0.98A | 4dc3A-2enxA:undetectable | 4dc3A-2enxA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f02 | TAGATOSE-6-PHOSPHATEKINASE (Enterococcusfaecalis) |
PF00294(PfkB) | 5 | ASP A 12GLY A 36ASN A 41GLY A 252ASP A 255 | NoneNoneNoneATP A 411 (-3.6A)ATP A 411 (-4.1A) | 0.88A | 4dc3A-2f02A:24.2 | 4dc3A-2f02A:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f43 | ATP SYNTHASE ALPHACHAIN, MITOCHONDRIAL (Rattusnorvegicus) |
PF00006(ATP-synt_ab)PF00306(ATP-synt_ab_C)PF02874(ATP-synt_ab_N) | 5 | ASP A 154LEU A 352GLY A 149ASN A 185VAL A 153 | None | 1.00A | 4dc3A-2f43A:2.3 | 4dc3A-2f43A:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fkn | UROCANATE HYDRATASE (Bacillussubtilis) |
PF01175(Urocanase)PF17391(Urocanase_N)PF17392(Urocanase_C) | 5 | ASN A 185VAL A 189THR A 166LEU A 161GLY A 175 | NoneNoneNoneNoneNAD A5555 (-3.7A) | 0.86A | 4dc3A-2fknA:3.5 | 4dc3A-2fknA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fkn | UROCANATE HYDRATASE (Bacillussubtilis) |
PF01175(Urocanase)PF17391(Urocanase_N)PF17392(Urocanase_C) | 5 | ASN A 185VAL A 189THR A 166LEU A 161GLY A 176 | None | 0.87A | 4dc3A-2fknA:3.5 | 4dc3A-2fknA:21.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2i6b | ADENOSINE KINASE (Homo sapiens) |
PF00294(PfkB) | 8 | ASN A 14ASP A 18LEU A 40GLY A 63ASN A 68LEU A 138GLY A 297ASP A 300 | 89I A 500 (-4.0A)None89I A 500 ( 4.8A)NoneNone89I A 500 (-4.4A)NoneNone | 0.92A | 4dc3A-2i6bA:41.5 | 4dc3A-2i6bA:36.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jg5 | FRUCTOSE 1-PHOSPHATEKINASE (Staphylococcusaureus) |
PF00294(PfkB) | 5 | ASP A 12GLY A 36ASN A 41GLY A 246ASP A 249 | None | 0.76A | 4dc3A-2jg5A:24.8 | 4dc3A-2jg5A:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qcv | PUTATIVE5-DEHYDRO-2-DEOXYGLUCONOKINASE (Bacillushalodurans) |
PF00294(PfkB) | 5 | ASP A 22GLY A 43ASN A 48GLY A 269ASP A 272 | NoneNoneNoneNonePGE A 332 (-3.6A) | 0.46A | 4dc3A-2qcvA:30.7 | 4dc3A-2qcvA:23.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v26 | MYOSIN VI (Sus scrofa) |
PF00063(Myosin_head) | 5 | ASN A 62LEU A 689ASN A 92VAL A 697LEU A 73 | None | 0.94A | 4dc3A-2v26A:undetectable | 4dc3A-2v26A:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xpz | LEUKOTRIENE A-4HYDROLASE (Saccharomycescerevisiae) |
PF01433(Peptidase_M1)PF09127(Leuk-A4-hydro_C) | 5 | ASN A 639LEU A 671GLY A 634VAL A 665GLY A 623 | None | 0.87A | 4dc3A-2xpzA:undetectable | 4dc3A-2xpzA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3all | 2-METHYL-3-HYDROXYPYRIDINE-5-CARBOXYLICACID OXYGENASE (Mesorhizobiumjaponicum) |
PF01494(FAD_binding_3) | 6 | LEU A 151GLY A 19ALA A 22VAL A 16LEU A 30GLY A 157 | NoneFAD A 380 ( 4.4A)FAD A 380 (-3.2A)NoneNoneFAD A 380 ( 3.8A) | 1.42A | 4dc3A-3allA:3.0 | 4dc3A-3allA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b1r | RIBOKINASE, PUTATIVE (Burkholderiathailandensis) |
PF00294(PfkB) | 5 | ASP A 12GLY A 47ASN A 52GLY A 250ASP A 253 | AMP A 501 (-2.9A)AMP A 501 ( 3.7A)AMP A 501 (-3.3A)AMP A 501 (-3.4A)AMP A 501 (-2.8A) | 0.75A | 4dc3A-3b1rA:26.1 | 4dc3A-3b1rA:24.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bdk | D-MANNONATEDEHYDRATASE (Streptococcussuis) |
PF03786(UxuA) | 5 | ASP A 308LEU A 150GLY A 307ASN A 289GLY A 259 | None | 0.99A | 4dc3A-3bdkA:undetectable | 4dc3A-3bdkA:25.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewm | UNCHARACTERIZEDSUGAR KINASE PH1459 (Pyrococcushorikoshii) |
PF00294(PfkB) | 6 | ASP A 13ALA A 35ASN A 38LEU A 167GLY A 244ASP A 247 | None | 1.12A | 4dc3A-3ewmA:30.0 | 4dc3A-3ewmA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewm | UNCHARACTERIZEDSUGAR KINASE PH1459 (Pyrococcushorikoshii) |
PF00294(PfkB) | 7 | ASP A 13LEU A 167GLY A 33ALA A 35ASN A 38GLY A 244ASP A 247 | None | 1.07A | 4dc3A-3ewmA:30.0 | 4dc3A-3ewmA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewm | UNCHARACTERIZEDSUGAR KINASE PH1459 (Pyrococcushorikoshii) |
PF00294(PfkB) | 7 | ASP A 13LEU A 167GLY A 33ALA A 35ASN A 38VAL A 90ASP A 247 | None | 0.89A | 4dc3A-3ewmA:30.0 | 4dc3A-3ewmA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewm | UNCHARACTERIZEDSUGAR KINASE PH1459 (Pyrococcushorikoshii) |
PF00294(PfkB) | 6 | LEU A 167ALA A 35ASN A 38LEU A 103GLY A 246ASP A 247 | None | 1.43A | 4dc3A-3ewmA:30.0 | 4dc3A-3ewmA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3go7 | RIBOKINASE RBSK (Mycobacteriumtuberculosis) |
PF00294(PfkB) | 5 | ASP A 25GLY A 50ASN A 55GLY A 239ASP A 242 | RIB A 305 (-2.8A)RIB A 305 ( 3.7A)RIB A 305 (-3.2A)RIB A 305 ( 4.5A)RIB A 305 (-2.9A) | 0.50A | 4dc3A-3go7A:26.1 | 4dc3A-3go7A:24.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hj6 | FRUCTOKINASE (Halothermothrixorenii) |
PF00294(PfkB) | 6 | ASP A 33LEU A 188GLY A 54ASN A 59VAL A 111ASP A 275 | None | 1.01A | 4dc3A-3hj6A:28.8 | 4dc3A-3hj6A:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrp | UNCHARACTERIZEDPROTEIN (Bacteroidesthetaiotaomicron) |
PF01833(TIG) | 5 | LEU A 247GLY A 243LEU A 254GLY A 348ASP A 405 | None | 0.99A | 4dc3A-3hrpA:undetectable | 4dc3A-3hrpA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hwr | 2-DEHYDROPANTOATE2-REDUCTASE (Cupriaviduspinatubonensis) |
PF02558(ApbA)PF08546(ApbA_C) | 5 | LEU A 72GLY A 23ALA A 161VAL A 26LEU A 70 | None | 0.96A | 4dc3A-3hwrA:5.7 | 4dc3A-3hwrA:25.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i3w | PHOSPHOGLUCOSAMINEMUTASE (Francisellatularensis) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | ASN A 205GLY A 182ALA A 203GLY A 216ASP A 178 | None | 0.93A | 4dc3A-3i3wA:undetectable | 4dc3A-3i3wA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i3y | CARBOHYDRATE KINASE (Klebsiellapneumoniae) |
PF00294(PfkB) | 5 | ASP A 12GLY A 37ASN A 42GLY A 229ASP A 232 | None | 0.89A | 4dc3A-3i3yA:25.1 | 4dc3A-3i3yA:26.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3in1 | UNCHARACTERIZEDSUGAR KINASE YDJH (Escherichiacoli) |
PF00294(PfkB) | 5 | ASP A 15GLY A 41ASN A 46GLY A 257ASP A 260 | NoneNoneNone NA A 411 ( 4.9A)None | 0.76A | 4dc3A-3in1A:29.8 | 4dc3A-3in1A:26.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lki | FRUCTOKINASE (Xylellafastidiosa) |
PF00294(PfkB) | 5 | ASP A 24GLY A 44ALA A 46ASN A 49ASP A 270 | None | 0.77A | 4dc3A-3lkiA:26.9 | 4dc3A-3lkiA:24.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3loo | ANOPHELES GAMBIAEADENOSINE KINASE (Anophelesgambiae) |
PF00294(PfkB) | 8 | ASN A 14ASP A 18LEU A 40GLY A 63ASN A 68LEU A 137GLY A 297ASP A 300 | B4P A 349 ( 4.0A)B4P A 349 (-2.8A)NoneB4P A 349 ( 3.8A)B4P A 349 (-3.6A)NoneB4P A 349 (-2.9A)B4P A 349 (-3.4A) | 0.55A | 4dc3A-3looA:46.4 | 4dc3A-3looA:38.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3loo | ANOPHELES GAMBIAEADENOSINE KINASE (Anophelesgambiae) |
PF00294(PfkB) | 6 | ASN A 14LEU A 40ASN A 68LEU A 137GLY A 299ASP A 300 | B4P A 349 ( 4.0A)NoneB4P A 349 (-3.6A)NoneB4P A 349 (-3.3A)B4P A 349 (-3.4A) | 1.37A | 4dc3A-3looA:46.4 | 4dc3A-3looA:38.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3otx | ADENOSINE KINASE,PUTATIVE (Trypanosomabrucei) |
PF00294(PfkB) | 7 | ASN A 13ASP A 17LEU A 39GLY A 62ASN A 67LEU A 138ASP A 299 | AP5 A 346 (-4.1A)AP5 A 346 (-2.8A)NoneAP5 A 346 (-3.6A)AP5 A 346 (-3.4A)NoneAP5 A 346 ( 3.2A) | 0.43A | 4dc3A-3otxA:43.6 | 4dc3A-3otxA:30.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3otx | ADENOSINE KINASE,PUTATIVE (Trypanosomabrucei) |
PF00294(PfkB) | 6 | ASN A 13LEU A 39ASN A 67LEU A 138GLY A 298ASP A 299 | AP5 A 346 (-4.1A)NoneAP5 A 346 (-3.4A)NoneAP5 A 346 (-3.2A)AP5 A 346 ( 3.2A) | 1.38A | 4dc3A-3otxA:43.6 | 4dc3A-3otxA:30.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pl2 | SUGAR KINASE,RIBOKINASE FAMILY (Corynebacteriumglutamicum) |
PF00294(PfkB) | 5 | ASP A 19GLY A 40ASN A 45GLY A 261ASP A 264 | None | 0.48A | 4dc3A-3pl2A:30.2 | 4dc3A-3pl2A:23.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q1y | LIN2199 PROTEIN (Listeriainnocua) |
PF00294(PfkB) | 5 | ASN A 8ASP A 12GLY A 37GLY A 248ASP A 251 | None | 0.98A | 4dc3A-3q1yA:24.7 | 4dc3A-3q1yA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rht | (GATASE1)-LIKEPROTEIN (Planctopiruslimnophila) |
PF07090(GATase1_like) | 5 | GLY A 83ASN A 152LEU A 79GLY A 90ASP A 113 | None | 1.00A | 4dc3A-3rhtA:3.0 | 4dc3A-3rhtA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ty4 | PROBABLEHOMOISOCITRATEDEHYDROGENASE (Schizosaccharomycespombe) |
PF00180(Iso_dh) | 5 | ALA A 14THR A 63LEU A 67GLY A 50ASP A 15 | NoneGOL A 363 (-3.9A)NoneNoneNone | 1.02A | 4dc3A-3ty4A:undetectable | 4dc3A-3ty4A:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4g | NAMN:DMBPHOSPHORIBOSYLTRANSFERASE (Pyrococcushorikoshii) |
no annotation | 5 | LEU A 289GLY A 300ALA A 66VAL A 297ASP A 40 | NoneNoneNoneNoneACY A 338 ( 4.2A) | 0.97A | 4dc3A-3u4gA:undetectable | 4dc3A-3u4gA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubo | ADENOSINE KINASE (Sinorhizobiummeliloti) |
PF00294(PfkB) | 10 | ASN A 11ASP A 15LEU A 37GLY A 58ASN A 63MET A 127THR A 129LEU A 131GLY A 275ASP A 278 | ADN A 353 (-3.7A)ADN A 353 (-2.8A)NoneADN A 353 (-3.3A)ADN A 353 (-3.4A)ADN A 353 (-3.3A)ADN A 353 (-3.3A)NoneADN A 353 (-3.7A)ADN A 353 (-3.3A) | 0.74A | 4dc3A-3uboA:38.0 | 4dc3A-3uboA:25.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubo | ADENOSINE KINASE (Sinorhizobiummeliloti) |
PF00294(PfkB) | 6 | ASP A 15LEU A 131ASN A 63THR A 129GLY A 275ASP A 278 | ADN A 353 (-2.8A)NoneADN A 353 (-3.4A)ADN A 353 (-3.3A)ADN A 353 (-3.7A)ADN A 353 (-3.3A) | 1.49A | 4dc3A-3uboA:38.0 | 4dc3A-3uboA:25.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubo | ADENOSINE KINASE (Sinorhizobiummeliloti) |
PF00294(PfkB) | 6 | LEU A 37GLY A 59ASN A 63MET A 127THR A 129LEU A 131 | NoneADN A 353 (-3.2A)ADN A 353 (-3.4A)ADN A 353 (-3.3A)ADN A 353 (-3.3A)None | 1.30A | 4dc3A-3uboA:38.0 | 4dc3A-3uboA:25.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ucq | AMYLOSUCRASE (Deinococcusgeothermalis) |
PF00128(Alpha-amylase) | 5 | LEU A 112ALA A 96VAL A 120LEU A 165GLY A 498 | None | 0.77A | 4dc3A-3ucqA:undetectable | 4dc3A-3ucqA:19.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vas | PUTATIVE ADENOSINEKINASE (Schistosomamansoni) |
PF00294(PfkB) | 12 | ASN A 14ASP A 18LEU A 40GLY A 63ALA A 65ASN A 68VAL A 123MET A 134THR A 136LEU A 138GLY A 299ASP A 302 | ADN A 401 ( 4.0A)ADN A 401 (-2.7A)NoneADN A 401 ( 3.8A)ADN A 401 (-3.8A)ADN A 401 (-3.7A)ADN A 401 (-4.5A)ADN A 401 ( 4.0A)ADN A 401 (-3.1A)ADN A 401 (-4.9A)ADN A 401 ( 3.8A)ADN A 401 (-2.9A) | 0.27A | 4dc3A-3vasA:57.8 | 4dc3A-3vasA:99.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vas | PUTATIVE ADENOSINEKINASE (Schistosomamansoni) |
PF00294(PfkB) | 6 | ASN A 14LEU A 40ALA A 65ASN A 68GLY A 301ASP A 302 | ADN A 401 ( 4.0A)NoneADN A 401 (-3.8A)ADN A 401 (-3.7A)NoneADN A 401 (-2.9A) | 1.38A | 4dc3A-3vasA:57.8 | 4dc3A-3vasA:99.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vas | PUTATIVE ADENOSINEKINASE (Schistosomamansoni) |
PF00294(PfkB) | 6 | GLY A 64ASN A 68VAL A 123MET A 134THR A 136GLY A 299 | ADN A 401 (-3.7A)ADN A 401 (-3.7A)ADN A 401 (-4.5A)ADN A 401 ( 4.0A)ADN A 401 (-3.1A)ADN A 401 ( 3.8A) | 1.15A | 4dc3A-3vasA:57.8 | 4dc3A-3vasA:99.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4anj | UNCONVENTIONALMYOSIN-VI, GREENFLUORESCENT PROTEIN (Aequoreavictoria;Sus scrofa) |
PF00063(Myosin_head)PF01353(GFP) | 5 | ASN A 62LEU A 689ASN A 92VAL A 697LEU A 73 | None | 1.00A | 4dc3A-4anjA:undetectable | 4dc3A-4anjA:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ays | AMYLOSUCRASE (Deinococcusradiodurans) |
PF00128(Alpha-amylase) | 5 | LEU A 108ALA A 92VAL A 116LEU A 161GLY A 490 | None | 0.92A | 4dc3A-4aysA:undetectable | 4dc3A-4aysA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cbp | NEURAL/ECTODERMALDEVELOPMENT FACTORIMP-L2 (Drosophilamelanogaster) |
PF07679(I-set) | 5 | LEU A 161GLY A 59ALA A 30GLY A 119ASP A 31 | None | 0.88A | 4dc3A-4cbpA:undetectable | 4dc3A-4cbpA:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4du5 | PFKB (Polaromonas sp.JS666) |
PF00294(PfkB) | 5 | LEU A 197ALA A 60ASN A 63GLY A 282ASP A 285 | None CL A 401 ( 4.3A)NoneNoneNone | 0.96A | 4dc3A-4du5A:30.5 | 4dc3A-4du5A:26.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3a | SUGAR KINASE PROTEIN (Rhizobium etli) |
PF00294(PfkB) | 10 | ASN A 9ASP A 13LEU A 35GLY A 56ASN A 61MET A 125THR A 127LEU A 129GLY A 273ASP A 276 | ADN A 500 (-3.8A)ADN A 500 (-2.7A)NoneADN A 500 (-3.5A)ADN A 500 (-3.5A)ADN A 500 (-3.4A)ADN A 500 (-3.0A)NoneADN A 500 (-3.9A)ADN A 500 (-2.8A) | 0.64A | 4dc3A-4e3aA:38.4 | 4dc3A-4e3aA:28.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3a | SUGAR KINASE PROTEIN (Rhizobium etli) |
PF00294(PfkB) | 6 | ASP A 13LEU A 129ASN A 61THR A 127GLY A 273ASP A 276 | ADN A 500 (-2.7A)NoneADN A 500 (-3.5A)ADN A 500 (-3.0A)ADN A 500 (-3.9A)ADN A 500 (-2.8A) | 1.42A | 4dc3A-4e3aA:38.4 | 4dc3A-4e3aA:28.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3a | SUGAR KINASE PROTEIN (Rhizobium etli) |
PF00294(PfkB) | 6 | LEU A 35GLY A 57ASN A 61MET A 125THR A 127LEU A 129 | NoneADN A 500 (-3.7A)ADN A 500 (-3.5A)ADN A 500 (-3.4A)ADN A 500 (-3.0A)None | 1.28A | 4dc3A-4e3aA:38.4 | 4dc3A-4e3aA:28.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f6t | MOLYBDENUM STORAGEPROTEIN SUBUNITALPHAMOLYBDENUM STORAGEPROTEIN SUBUNIT BETA (Azotobactervinelandii) |
PF00696(AA_kinase) | 5 | ASP A 52LEU B 12ALA A 80ASN A 112GLY A 47 | NoneNoneATP A 301 (-3.7A)NoneATP A 301 (-3.1A) | 0.96A | 4dc3A-4f6tA:undetectable | 4dc3A-4f6tA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g8k | 2-5A-DEPENDENTRIBONUCLEASE (Homo sapiens) |
PF12796(Ank_2)PF13857(Ank_5) | 5 | LEU A 226ALA A 246VAL A 218THR A 222LEU A 206 | None | 1.03A | 4dc3A-4g8kA:undetectable | 4dc3A-4g8kA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gm6 | PFKB FAMILYCARBOHYDRATE KINASE (Listeria grayi) |
PF00294(PfkB) | 6 | LEU A 172ALA A 35ASN A 38LEU A 140GLY A 267ASP A 270 | NoneGOL A 401 (-3.9A)GOL A 401 (-4.4A)NoneGOL A 401 ( 4.5A)GOL A 401 (-3.0A) | 1.08A | 4dc3A-4gm6A:27.6 | 4dc3A-4gm6A:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gm6 | PFKB FAMILYCARBOHYDRATE KINASE (Listeria grayi) |
PF00294(PfkB) | 6 | LEU A 172GLY A 33ALA A 35ASN A 38GLY A 267ASP A 270 | NoneGOL A 401 ( 4.1A)GOL A 401 (-3.9A)GOL A 401 (-4.4A)GOL A 401 ( 4.5A)GOL A 401 (-3.0A) | 0.91A | 4dc3A-4gm6A:27.6 | 4dc3A-4gm6A:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ixu | ARGINASE-2,MITOCHONDRIAL (Homo sapiens) |
PF00491(Arginase) | 5 | LEU A 238GLY A 197MET A 231THR A 234GLY A 276 | None | 0.90A | 4dc3A-4ixuA:3.9 | 4dc3A-4ixuA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jlw | GLUTATHIONE-INDEPENDENT FORMALDEHYDEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 199ALA A 193LEU A 224GLY A 264ASP A 261 | NoneNAD A 403 ( 4.1A)NoneNAD A 403 ( 4.1A)None | 1.00A | 4dc3A-4jlwA:4.8 | 4dc3A-4jlwA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kt1 | LEUCINE-RICHREPEAT-CONTAININGG-PROTEIN COUPLEDRECEPTOR 4 (Homo sapiens) |
PF01462(LRRNT)PF13516(LRR_6)PF13855(LRR_8) | 5 | LEU A 321ALA A 291THR A 318LEU A 298ASP A 265 | None | 0.98A | 4dc3A-4kt1A:undetectable | 4dc3A-4kt1A:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o2h | PROTEIN BCAM1869 (Burkholderiacenocepacia) |
PF16245(DUF4902) | 5 | LEU A 116MET A 109THR A 112LEU A 25ASP A 15 | None | 0.96A | 4dc3A-4o2hA:undetectable | 4dc3A-4o2hA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4okd | ISOAMYLASE (Chlamydomonasreinhardtii) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | LEU A 681GLY A 696THR A 677GLY A 726ASP A 723 | None | 0.83A | 4dc3A-4okdA:undetectable | 4dc3A-4okdA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oso | REDUCTASE HOMOLOG (Streptomycescyanogenus) |
PF13561(adh_short_C2) | 5 | LEU A 78GLY A 6ALA A 31LEU A 91GLY A 56 | None | 1.00A | 4dc3A-4osoA:7.4 | 4dc3A-4osoA:25.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pvv | ADENOSINE KINASE (Mycobacteriumtuberculosis) |
PF00294(PfkB) | 5 | ASP A 12GLY A 47ASN A 52GLY A 254ASP A 257 | HO4 A 401 (-2.4A)HO4 A 401 (-3.5A)HO4 A 401 (-3.8A)HO4 A 401 ( 4.3A)HO4 A 401 (-3.3A) | 0.74A | 4dc3A-4pvvA:26.9 | 4dc3A-4pvvA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjm | RIBOKINASE:CARBOHYDRATE KINASE, PFKB (Brucellaabortus) |
PF00294(PfkB) | 5 | ASP A 11GLY A 29ASN A 34GLY A 246ASP A 249 | NoneNoneNoneANP A 401 (-3.3A)ANP A 401 ( 4.3A) | 0.54A | 4dc3A-4wjmA:29.1 | 4dc3A-4wjmA:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjm | RIBOKINASE:CARBOHYDRATE KINASE, PFKB (Brucellaabortus) |
PF00294(PfkB) | 5 | LEU A 162GLY A 29ASN A 34GLY A 246ASP A 249 | NoneNoneNoneANP A 401 (-3.3A)ANP A 401 ( 4.3A) | 0.95A | 4dc3A-4wjmA:29.1 | 4dc3A-4wjmA:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wnx | NETRIN-4 (Mus musculus) |
PF00053(Laminin_EGF)PF00055(Laminin_N) | 5 | LEU A 201GLY A 266LEU A 219GLY A 324ASP A 320 | None | 1.01A | 4dc3A-4wnxA:undetectable | 4dc3A-4wnxA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wy8 | ESTERASE (Rhizomucormiehei) |
PF07859(Abhydrolase_3) | 5 | LEU A 107GLY A 292THR A 103LEU A 307GLY A 90 | None | 0.89A | 4dc3A-4wy8A:4.0 | 4dc3A-4wy8A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a31 | ANAPHASE-PROMOTINGCOMPLEX SUBUNIT 1 (Homo sapiens) |
PF12859(ANAPC1) | 5 | LEU A1488GLY A1531ALA A1528VAL A1535GLY A1563 | None | 0.93A | 4dc3A-5a31A:undetectable | 4dc3A-5a31A:14.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c41 | RIBOKINASE (Homo sapiens) |
PF00294(PfkB) | 5 | ASP A 27GLY A 52ASN A 57GLY A 266ASP A 269 | NoneNoneNoneACP A 401 ( 4.1A) NA A 403 ( 4.7A) | 0.57A | 4dc3A-5c41A:31.8 | 4dc3A-5c41A:25.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dn6 | ATP SYNTHASE SUBUNITALPHA (Paracoccusdenitrificans) |
PF00006(ATP-synt_ab)PF00306(ATP-synt_ab_C)PF02874(ATP-synt_ab_N) | 5 | ASP A 154LEU A 353GLY A 149ASN A 185VAL A 153 | None | 0.99A | 4dc3A-5dn6A:2.4 | 4dc3A-5dn6A:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ey7 | FRUCTOKINASE (Vibrio cholerae) |
PF00294(PfkB) | 7 | ASP A 30GLY A 44ALA A 46ASN A 49VAL A 101GLY A 263ASP A 266 | None | 0.70A | 4dc3A-5ey7A:29.6 | 4dc3A-5ey7A:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hft | GAMMA-GLUTAMYLTRANSPEPTIDASE (Klebsiellapneumoniae) |
PF01019(G_glu_transpept) | 5 | LEU A 208GLY A 110LEU A 195GLY A 76ASP A 57 | None | 0.88A | 4dc3A-5hftA:undetectable | 4dc3A-5hftA:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ks8 | PYRUVATE CARBOXYLASESUBUNIT BETA (Methylobacillusflagellatus) |
PF00364(Biotin_lipoyl)PF00682(HMGL-like)PF02436(PYC_OADA) | 5 | ASP C 8GLY C 228ALA C 241VAL C 10LEU C 18 | None | 0.87A | 4dc3A-5ks8C:undetectable | 4dc3A-5ks8C:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l3q | SIGNAL RECOGNITIONPARTICLE RECEPTORSUBUNIT ALPHA (Homo sapiens) |
PF00448(SRP54)PF02881(SRP54_N) | 5 | LEU B 397GLY B 551ALA B 553LEU B 626GLY B 556 | None | 0.95A | 4dc3A-5l3qB:2.1 | 4dc3A-5l3qB:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lcw | ANAPHASE-PROMOTINGCOMPLEX SUBUNIT 1 (Homo sapiens) |
PF12859(ANAPC1) | 5 | LEU A1488GLY A1531ALA A1528VAL A1535GLY A1563 | None | 0.89A | 4dc3A-5lcwA:undetectable | 4dc3A-5lcwA:10.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nkm | PROTEIN SMG-9 (Caenorhabditiselegans) |
no annotation | 5 | LEU D 282GLY D 93ALA D 91THR D 240ASP D 150 | None | 0.97A | 4dc3A-5nkmD:3.1 | 4dc3A-5nkmD:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oc1 | ARYL-ALCOHOL OXIDASE (Pleurotuseryngii) |
no annotation | 5 | LEU A 234GLY A 307ALA A 507LEU A 280GLY A 517 | NoneNoneNoneFAD A 602 ( 4.3A)None | 1.02A | 4dc3A-5oc1A:2.9 | 4dc3A-5oc1A:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z96 | SHORT TRANSIENTRECEPTOR POTENTIALCHANNEL 4 (Mus musculus) |
no annotation | 5 | GLY A 43ALA A 77ASN A 82VAL A 48LEU A 37 | None | 1.03A | 4dc3A-5z96A:undetectable | 4dc3A-5z96A:11.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zrx | PHOSPHATIDYLINOSITOL3,4,5-TRISPHOSPHATE5-PHOSPHATASE2,EPHRIN TYPE-ARECEPTOR 2 (Mus musculus) |
no annotation | 5 | LEU A1255GLY A1208ALA A1206THR A1252GLY A1201 | None | 0.96A | 4dc3A-5zrxA:undetectable | 4dc3A-5zrxA:13.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cw5 | RIBOKINASE (Cryptococcusneoformans) |
no annotation | 5 | ASP A 16GLY A 41ASN A 46GLY A 270ASP A 273 | GOL A 400 (-2.8A)GOL A 400 (-3.5A)GOL A 400 (-3.3A)NoneNone | 0.70A | 4dc3A-6cw5A:28.6 | 4dc3A-6cw5A:12.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f5d | ATP SYNTHASE ALPHACHAIN, MITOCHONDRIAL (Trypanosomabrucei) |
no annotation | 5 | ASP A 167LEU A 365GLY A 162ASN A 198VAL A 166 | None | 0.98A | 4dc3A-6f5dA:2.2 | 4dc3A-6f5dA:13.07 |