SIMILAR PATTERNS OF AMINO ACIDS FOR 4DAJ_B_0HKB2000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME ALPHA
SUBUNIT

(Archaeoglobus
fulgidus) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ASP A 152
SER A 135
THR A 173
ALA A  37
TYR A 160
 None
 1.38A 4dajB-1j2qA:
undetectable		 4dajB-1j2qA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upr PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 4

(Homo sapiens) 		PF00169
(PH) 		5 ASP A1065
TRP A1072
THR A1122
THR A1120
ALA A1134
 4IP  A2154 (-3.7A)
None
None
None
None
 1.36A 4dajB-1uprA:
undetectable		 4dajB-1uprA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 ASP A 667
TYR A 666
TRP A 650
THR A 321
ALA A 718
 None
 1.30A 4dajB-1v7vA:
0.1		 4dajB-1v7vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy0 RAN
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF07834
(RanGAP1_C) 		5 ASP C 495
THR C 463
THR C 461
ALA C 472
TYR C 550
 None
 1.38A 4dajB-2iy0C:
undetectable		 4dajB-2iy0C:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29) 		PF03175
(DNA_pol_B_2) 		5 THR A 457
THR A 441
ALA A 445
TYR A 454
TYR A 500
 DGT  A1588 ( 4.3A)
None
None
None
None
 1.43A 4dajB-2pyjA:
undetectable		 4dajB-2pyjA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdr BETAINE ALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		5 SER A 103
THR A  94
THR A  91
ALA A  87
TYR A 154
 None
None
None
None
TOE  A1492 ( 4.1A)
 1.41A 4dajB-2xdrA:
0.0		 4dajB-2xdrA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		5 ASP X 182
TYR X 146
THR X  61
ALA X  40
TYR X  15
 None
FE  X 326 (-4.3A)
None
None
FE  X 326 (-4.3A)
 1.50A 4dajB-3e13X:
0.0		 4dajB-3e13X:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugg SUCROSE:(SUCROSE/FRU
CTAN)
6-FRUCTOSYLTRANSFERA
SE

(Pachysandra
terminalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 ASP A 312
SER A 308
TRP A  10
THR A 507
ALA A 458
 None
 1.46A 4dajB-3uggA:
undetectable		 4dajB-3uggA:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ASP A 103
TYR A 104
ALA A 191
TYR A 426
CYH A 429
 QNB  A1162 (-3.1A)
QNB  A1162 (-4.0A)
QNB  A1162 (-3.9A)
QNB  A1162 ( 4.2A)
QNB  A1162 ( 4.0A)
 1.40A 4dajB-3uonA:
39.8		 4dajB-3uonA:
73.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		12 ASP A 103
TYR A 104
SER A 107
TRP A 155
THR A 187
THR A 190
ALA A 194
TRP A 400
TYR A 403
ASN A 404
TYR A 426
CYH A 429
 QNB  A1162 (-3.1A)
QNB  A1162 (-4.0A)
QNB  A1162 (-3.4A)
QNB  A1162 (-4.2A)
QNB  A1162 (-4.8A)
QNB  A1162 (-4.3A)
QNB  A1162 ( 4.0A)
QNB  A1162 (-4.7A)
QNB  A1162 (-3.9A)
QNB  A1162 (-2.9A)
QNB  A1162 ( 4.2A)
QNB  A1162 ( 4.0A)
 0.75A 4dajB-3uonA:
39.8		 4dajB-3uonA:
73.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ASP A 103
TYR A 104
THR A 187
ALA A 191
CYH A 429
 QNB  A1162 (-3.1A)
QNB  A1162 (-4.0A)
QNB  A1162 (-4.8A)
QNB  A1162 (-3.9A)
QNB  A1162 ( 4.0A)
 1.29A 4dajB-3uonA:
39.8		 4dajB-3uonA:
73.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ASP A 103
TYR A 104
THR A 190
TRP A 400
ASN A 404
CYH A 429
 QNB  A1162 (-3.1A)
QNB  A1162 (-4.0A)
QNB  A1162 (-4.3A)
QNB  A1162 (-4.7A)
QNB  A1162 (-2.9A)
QNB  A1162 ( 4.0A)
 1.43A 4dajB-3uonA:
39.8		 4dajB-3uonA:
73.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		5 ASP A 103
SER A 107
TRP A 400
TYR A 403
ASN A 404
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.4A)
IXO  A 501 (-4.6A)
IXO  A 501 (-3.8A)
IXO  A 501 (-3.0A)
 1.38A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		6 ASP A 103
SER A 107
TYR A 403
ASN A 404
TYR A 426
CYH A 429
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.4A)
IXO  A 501 (-3.8A)
IXO  A 501 (-3.0A)
2CU  A 502 ( 3.9A)
IXO  A 501 (-3.5A)
 1.06A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		6 ASP A 103
THR A 187
THR A 190
TRP A 400
TYR A 403
ASN A 404
 IXO  A 501 (-3.4A)
None
None
IXO  A 501 (-4.6A)
IXO  A 501 (-3.8A)
IXO  A 501 (-3.0A)
 1.24A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		7 ASP A 103
THR A 187
THR A 190
TYR A 403
ASN A 404
TYR A 426
CYH A 429
 IXO  A 501 (-3.4A)
None
None
IXO  A 501 (-3.8A)
IXO  A 501 (-3.0A)
2CU  A 502 ( 3.9A)
IXO  A 501 (-3.5A)
 0.93A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		6 ASP A 103
TYR A 104
SER A 107
ALA A 194
ASN A 404
TYR A 426
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
IXO  A 501 (-3.4A)
IXO  A 501 (-3.5A)
IXO  A 501 (-3.0A)
2CU  A 502 ( 3.9A)
 0.97A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		6 ASP A 103
TYR A 104
SER A 107
ALA A 194
TRP A 400
ASN A 404
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
IXO  A 501 (-3.4A)
IXO  A 501 (-3.5A)
IXO  A 501 (-4.6A)
IXO  A 501 (-3.0A)
 1.27A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		6 ASP A 103
TYR A 104
SER A 107
ASN A 404
TYR A 426
CYH A 429
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
IXO  A 501 (-3.4A)
IXO  A 501 (-3.0A)
2CU  A 502 ( 3.9A)
IXO  A 501 (-3.5A)
 0.97A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		6 ASP A 103
TYR A 104
THR A 187
ALA A 191
TYR A 426
CYH A 429
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
None
None
2CU  A 502 ( 3.9A)
IXO  A 501 (-3.5A)
 1.20A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		6 ASP A 103
TYR A 104
THR A 187
ASN A 404
TYR A 426
CYH A 429
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
None
IXO  A 501 (-3.0A)
2CU  A 502 ( 3.9A)
IXO  A 501 (-3.5A)
 1.38A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		7 ASP A 103
TYR A 104
THR A 187
THR A 190
ALA A 194
ASN A 404
TYR A 426
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
None
None
IXO  A 501 (-3.5A)
IXO  A 501 (-3.0A)
2CU  A 502 ( 3.9A)
 0.93A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		7 ASP A 103
TYR A 104
THR A 187
THR A 190
ALA A 194
TRP A 400
ASN A 404
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
None
None
IXO  A 501 (-3.5A)
IXO  A 501 (-4.6A)
IXO  A 501 (-3.0A)
 1.21A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		7 ASP A 103
TYR A 104
THR A 187
THR A 190
ASN A 404
TYR A 426
CYH A 429
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
None
None
IXO  A 501 (-3.0A)
2CU  A 502 ( 3.9A)
IXO  A 501 (-3.5A)
 0.81A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		5 ASP A 103
TYR A 104
TRP A 155
ALA A 191
TYR A 426
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
IXO  A 501 (-3.6A)
None
2CU  A 502 ( 3.9A)
 1.09A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		5 ASP A 103
TYR A 104
TRP A 155
THR A 187
TRP A 400
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
IXO  A 501 (-3.6A)
None
IXO  A 501 (-4.6A)
 1.32A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		5 ASP A 103
TYR A 104
TRP A 155
THR A 187
TYR A 426
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
IXO  A 501 (-3.6A)
None
2CU  A 502 ( 3.9A)
 0.91A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		12 ASP A 147
TYR A 148
SER A 151
TRP A 199
THR A 231
THR A 234
ALA A 238
TRP A 503
TYR A 506
ASN A 507
TYR A 529
CYH A 532
 0HK  A2000 (-3.2A)
0HK  A2000 (-2.8A)
0HK  A2000 (-3.3A)
0HK  A2000 (-4.5A)
0HK  A2000 (-4.3A)
None
0HK  A2000 ( 3.8A)
0HK  A2000 (-4.3A)
0HK  A2000 (-4.1A)
0HK  A2000 (-2.9A)
0HK  A2000 (-4.1A)
0HK  A2000 (-3.9A)
 0.40A 4dajB-4u14A:
48.1		 4dajB-4u14A:
95.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ASP A 147
TYR A 148
THR A 231
ALA A 235
TYR A 529
CYH A 532
 0HK  A2000 (-3.2A)
0HK  A2000 (-2.8A)
0HK  A2000 (-4.3A)
0HK  A2000 ( 3.9A)
0HK  A2000 (-4.1A)
0HK  A2000 (-3.9A)
 1.37A 4dajB-4u14A:
48.1		 4dajB-4u14A:
95.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 ASP A 147
TYR A 148
THR A 231
TRP A 503
ASN A 507
TYR A 529
CYH A 532
 0HK  A2000 (-3.2A)
0HK  A2000 (-2.8A)
0HK  A2000 (-4.3A)
0HK  A2000 (-4.3A)
0HK  A2000 (-2.9A)
0HK  A2000 (-4.1A)
0HK  A2000 (-3.9A)
 1.39A 4dajB-4u14A:
48.1		 4dajB-4u14A:
95.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 SER A 151
TRP A 503
TYR A 529
TYR A 533
CYH A 532
 0HK  A2000 (-3.3A)
0HK  A2000 (-4.3A)
0HK  A2000 (-4.1A)
None
0HK  A2000 (-3.9A)
 1.39A 4dajB-4u14A:
48.1		 4dajB-4u14A:
95.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u16 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		12 ASP A 147
TYR A 148
SER A 151
TRP A 199
THR A 231
THR A 234
ALA A 238
TRP A 503
TYR A 506
ASN A 507
TYR A 529
CYH A 532
 3C0  A1202 (-3.4A)
3C0  A1202 (-3.7A)
3C0  A1202 (-2.9A)
3C0  A1202 (-4.4A)
None
None
3C0  A1202 (-3.5A)
3C0  A1202 ( 4.0A)
3C0  A1202 (-3.7A)
3C0  A1202 (-2.9A)
3C0  A1202 (-3.7A)
3C0  A1202 (-3.6A)
 0.43A 4dajB-4u16A:
35.7		 4dajB-4u16A:
86.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u16 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 ASP A 147
TYR A 148
THR A 231
TRP A 503
ASN A 507
TYR A 529
CYH A 532
 3C0  A1202 (-3.4A)
3C0  A1202 (-3.7A)
None
3C0  A1202 ( 4.0A)
3C0  A1202 (-2.9A)
3C0  A1202 (-3.7A)
3C0  A1202 (-3.6A)
 1.33A 4dajB-4u16A:
35.7		 4dajB-4u16A:
86.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u16 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TYR A 148
THR A 231
ALA A 235
TYR A 529
CYH A 532
 3C0  A1202 (-3.7A)
None
3C0  A1202 (-3.5A)
3C0  A1202 (-3.7A)
3C0  A1202 (-3.6A)
 1.40A 4dajB-4u16A:
35.7		 4dajB-4u16A:
86.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cxv MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		10 ASP A 105
TYR A 106
SER A 109
THR A 189
ALA A 196
TRP A 378
TYR A 381
ASN A 382
TYR A 404
CYH A 407
 0HK  A 501 (-3.0A)
0HK  A 501 (-3.4A)
0HK  A 501 (-3.1A)
0HK  A 501 (-4.4A)
0HK  A 501 (-3.6A)
0HK  A 501 (-4.4A)
0HK  A 501 (-4.1A)
0HK  A 501 (-2.8A)
0HK  A 501 (-3.6A)
0HK  A 501 (-3.7A)
 0.59A 4dajB-5cxvA:
43.4		 4dajB-5cxvA:
74.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cxv MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 ASP A 105
TYR A 106
THR A 192
TRP A 378
ASN A 382
TYR A 404
CYH A 407
 0HK  A 501 (-3.0A)
0HK  A 501 (-3.4A)
0HK  A 501 (-4.0A)
0HK  A 501 (-4.4A)
0HK  A 501 (-2.8A)
0HK  A 501 (-3.6A)
0HK  A 501 (-3.7A)
 1.22A 4dajB-5cxvA:
43.4		 4dajB-5cxvA:
74.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cxv MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		11 ASP A 105
TYR A 106
TRP A 157
THR A 189
THR A 192
ALA A 196
TRP A 378
TYR A 381
ASN A 382
TYR A 404
CYH A 407
 0HK  A 501 (-3.0A)
0HK  A 501 (-3.4A)
0HK  A 501 (-4.0A)
0HK  A 501 (-4.4A)
0HK  A 501 (-4.0A)
0HK  A 501 (-3.6A)
0HK  A 501 (-4.4A)
0HK  A 501 (-4.1A)
0HK  A 501 (-2.8A)
0HK  A 501 (-3.6A)
0HK  A 501 (-3.7A)
 0.45A 4dajB-5cxvA:
43.4		 4dajB-5cxvA:
74.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		11 ASP A 112
TYR A 113
SER A 116
THR A 196
THR A 199
ALA A 203
TRP A 413
TYR A 416
ASN A 417
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
0HK  A1201 (-3.3A)
P6G  A1205 (-4.6A)
OLC  A1208 (-4.4A)
0HK  A1201 (-3.6A)
0HK  A1201 (-4.3A)
0HK  A1201 (-4.2A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 0.64A 4dajB-5dsgA:
42.1		 4dajB-5dsgA:
66.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 ASP A 112
TYR A 113
THR A 196
TRP A 413
ASN A 417
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
P6G  A1205 (-4.6A)
0HK  A1201 (-4.3A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 1.46A 4dajB-5dsgA:
42.1		 4dajB-5dsgA:
66.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		11 ASP A 112
TYR A 113
TRP A 164
THR A 196
THR A 199
ALA A 203
TRP A 413
TYR A 416
ASN A 417
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
OLC  A1208 ( 4.0A)
P6G  A1205 (-4.6A)
OLC  A1208 (-4.4A)
0HK  A1201 (-3.6A)
0HK  A1201 (-4.3A)
0HK  A1201 (-4.2A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 0.51A 4dajB-5dsgA:
42.1		 4dajB-5dsgA:
66.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TYR A 113
THR A 196
ALA A 200
TYR A 439
CYH A 442
 0HK  A1201 ( 3.2A)
P6G  A1205 (-4.6A)
0HK  A1201 ( 4.2A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 1.30A 4dajB-5dsgA:
42.1		 4dajB-5dsgA:
66.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpw PRO CATHEPSIN B S9

(Trypanosoma
congolense) 		PF00112
(Peptidase_C1) 		5 ASP A 239
THR A 259
THR A  47
ALA A  43
TYR A 248
 None
 1.42A 4dajB-5fpwA:
undetectable		 4dajB-5fpwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h20 -

(-) 		no annotation 5 SER A 102
THR A 212
THR A 211
ALA A 144
TYR A 276
 None
ASN  A 401 (-3.5A)
ASN  A 401 (-4.0A)
ASN  A 401 ( 4.3A)
ASN  A 401 ( 4.9A)
 1.13A 4dajB-6h20A:
0.2		 4dajB-6h20A:
undetectable