SIMILAR PATTERNS OF AMINO ACIDS FOR 4DAJ_B_0HKB2000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME ALPHA
SUBUNIT

(Archaeoglobus
fulgidus) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ASP A 152
SER A 135
THR A 173
ALA A  37
TYR A 160
 None
 1.38A 4dajB-1j2qA:
undetectable		 4dajB-1j2qA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upr PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 4

(Homo sapiens) 		PF00169
(PH) 		5 ASP A1065
TRP A1072
THR A1122
THR A1120
ALA A1134
 4IP  A2154 (-3.7A)
None
None
None
None
 1.36A 4dajB-1uprA:
undetectable		 4dajB-1uprA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 ASP A 667
TYR A 666
TRP A 650
THR A 321
ALA A 718
 None
 1.30A 4dajB-1v7vA:
0.1		 4dajB-1v7vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy0 RAN
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF07834
(RanGAP1_C) 		5 ASP C 495
THR C 463
THR C 461
ALA C 472
TYR C 550
 None
 1.38A 4dajB-2iy0C:
undetectable		 4dajB-2iy0C:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29) 		PF03175
(DNA_pol_B_2) 		5 THR A 457
THR A 441
ALA A 445
TYR A 454
TYR A 500
 DGT  A1588 ( 4.3A)
None
None
None
None
 1.43A 4dajB-2pyjA:
undetectable		 4dajB-2pyjA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdr BETAINE ALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		5 SER A 103
THR A  94
THR A  91
ALA A  87
TYR A 154
 None
None
None
None
TOE  A1492 ( 4.1A)
 1.41A 4dajB-2xdrA:
0.0		 4dajB-2xdrA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		5 ASP X 182
TYR X 146
THR X  61
ALA X  40
TYR X  15
 None
FE  X 326 (-4.3A)
None
None
FE  X 326 (-4.3A)
 1.50A 4dajB-3e13X:
0.0		 4dajB-3e13X:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugg SUCROSE:(SUCROSE/FRU
CTAN)
6-FRUCTOSYLTRANSFERA
SE

(Pachysandra
terminalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 ASP A 312
SER A 308
TRP A  10
THR A 507
ALA A 458
 None
 1.46A 4dajB-3uggA:
undetectable		 4dajB-3uggA:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ASP A 103
TYR A 104
ALA A 191
TYR A 426
CYH A 429
 QNB  A1162 (-3.1A)
QNB  A1162 (-4.0A)
QNB  A1162 (-3.9A)
QNB  A1162 ( 4.2A)
QNB  A1162 ( 4.0A)
 1.40A 4dajB-3uonA:
39.8		 4dajB-3uonA:
73.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		12 ASP A 103
TYR A 104
SER A 107
TRP A 155
THR A 187
THR A 190
ALA A 194
TRP A 400
TYR A 403
ASN A 404
TYR A 426
CYH A 429
 QNB  A1162 (-3.1A)
QNB  A1162 (-4.0A)
QNB  A1162 (-3.4A)
QNB  A1162 (-4.2A)
QNB  A1162 (-4.8A)
QNB  A1162 (-4.3A)
QNB  A1162 ( 4.0A)
QNB  A1162 (-4.7A)
QNB  A1162 (-3.9A)
QNB  A1162 (-2.9A)
QNB  A1162 ( 4.2A)
QNB  A1162 ( 4.0A)
 0.75A 4dajB-3uonA:
39.8		 4dajB-3uonA:
73.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ASP A 103
TYR A 104
THR A 187
ALA A 191
CYH A 429
 QNB  A1162 (-3.1A)
QNB  A1162 (-4.0A)
QNB  A1162 (-4.8A)
QNB  A1162 (-3.9A)
QNB  A1162 ( 4.0A)
 1.29A 4dajB-3uonA:
39.8		 4dajB-3uonA:
73.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ASP A 103
TYR A 104
THR A 190
TRP A 400
ASN A 404
CYH A 429
 QNB  A1162 (-3.1A)
QNB  A1162 (-4.0A)
QNB  A1162 (-4.3A)
QNB  A1162 (-4.7A)
QNB  A1162 (-2.9A)
QNB  A1162 ( 4.0A)
 1.43A 4dajB-3uonA:
39.8		 4dajB-3uonA:
73.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		5 ASP A 103
SER A 107
TRP A 400
TYR A 403
ASN A 404
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.4A)
IXO  A 501 (-4.6A)
IXO  A 501 (-3.8A)
IXO  A 501 (-3.0A)
 1.38A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		6 ASP A 103
SER A 107
TYR A 403
ASN A 404
TYR A 426
CYH A 429
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.4A)
IXO  A 501 (-3.8A)
IXO  A 501 (-3.0A)
2CU  A 502 ( 3.9A)
IXO  A 501 (-3.5A)
 1.06A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		6 ASP A 103
THR A 187
THR A 190
TRP A 400
TYR A 403
ASN A 404
 IXO  A 501 (-3.4A)
None
None
IXO  A 501 (-4.6A)
IXO  A 501 (-3.8A)
IXO  A 501 (-3.0A)
 1.24A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		7 ASP A 103
THR A 187
THR A 190
TYR A 403
ASN A 404
TYR A 426
CYH A 429
 IXO  A 501 (-3.4A)
None
None
IXO  A 501 (-3.8A)
IXO  A 501 (-3.0A)
2CU  A 502 ( 3.9A)
IXO  A 501 (-3.5A)
 0.93A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		6 ASP A 103
TYR A 104
SER A 107
ALA A 194
ASN A 404
TYR A 426
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
IXO  A 501 (-3.4A)
IXO  A 501 (-3.5A)
IXO  A 501 (-3.0A)
2CU  A 502 ( 3.9A)
 0.97A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		6 ASP A 103
TYR A 104
SER A 107
ALA A 194
TRP A 400
ASN A 404
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
IXO  A 501 (-3.4A)
IXO  A 501 (-3.5A)
IXO  A 501 (-4.6A)
IXO  A 501 (-3.0A)
 1.27A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		6 ASP A 103
TYR A 104
SER A 107
ASN A 404
TYR A 426
CYH A 429
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
IXO  A 501 (-3.4A)
IXO  A 501 (-3.0A)
2CU  A 502 ( 3.9A)
IXO  A 501 (-3.5A)
 0.97A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		6 ASP A 103
TYR A 104
THR A 187
ALA A 191
TYR A 426
CYH A 429
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
None
None
2CU  A 502 ( 3.9A)
IXO  A 501 (-3.5A)
 1.20A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		6 ASP A 103
TYR A 104
THR A 187
ASN A 404
TYR A 426
CYH A 429
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
None
IXO  A 501 (-3.0A)
2CU  A 502 ( 3.9A)
IXO  A 501 (-3.5A)
 1.38A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		7 ASP A 103
TYR A 104
THR A 187
THR A 190
ALA A 194
ASN A 404
TYR A 426
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
None
None
IXO  A 501 (-3.5A)
IXO  A 501 (-3.0A)
2CU  A 502 ( 3.9A)
 0.93A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		7 ASP A 103
TYR A 104
THR A 187
THR A 190
ALA A 194
TRP A 400
ASN A 404
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
None
None
IXO  A 501 (-3.5A)
IXO  A 501 (-4.6A)
IXO  A 501 (-3.0A)
 1.21A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		7 ASP A 103
TYR A 104
THR A 187
THR A 190
ASN A 404
TYR A 426
CYH A 429
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
None
None
IXO  A 501 (-3.0A)
2CU  A 502 ( 3.9A)
IXO  A 501 (-3.5A)
 0.81A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		5 ASP A 103
TYR A 104
TRP A 155
ALA A 191
TYR A 426
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
IXO  A 501 (-3.6A)
None
2CU  A 502 ( 3.9A)
 1.09A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		5 ASP A 103
TYR A 104
TRP A 155
THR A 187
TRP A 400
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
IXO  A 501 (-3.6A)
None
IXO  A 501 (-4.6A)
 1.32A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		5 ASP A 103
TYR A 104
TRP A 155
THR A 187
TYR A 426
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
IXO  A 501 (-3.6A)
None
2CU  A 502 ( 3.9A)
 0.91A 4dajB-4mqtA:
32.3		 4dajB-4mqtA:
44.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		12 ASP A 147
TYR A 148
SER A 151
TRP A 199
THR A 231
THR A 234
ALA A 238
TRP A 503
TYR A 506
ASN A 507
TYR A 529
CYH A 532
 0HK  A2000 (-3.2A)
0HK  A2000 (-2.8A)
0HK  A2000 (-3.3A)
0HK  A2000 (-4.5A)
0HK  A2000 (-4.3A)
None
0HK  A2000 ( 3.8A)
0HK  A2000 (-4.3A)
0HK  A2000 (-4.1A)
0HK  A2000 (-2.9A)
0HK  A2000 (-4.1A)
0HK  A2000 (-3.9A)
 0.40A 4dajB-4u14A:
48.1		 4dajB-4u14A:
95.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ASP A 147
TYR A 148
THR A 231
ALA A 235
TYR A 529
CYH A 532
 0HK  A2000 (-3.2A)
0HK  A2000 (-2.8A)
0HK  A2000 (-4.3A)
0HK  A2000 ( 3.9A)
0HK  A2000 (-4.1A)
0HK  A2000 (-3.9A)
 1.37A 4dajB-4u14A:
48.1		 4dajB-4u14A:
95.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 ASP A 147
TYR A 148
THR A 231
TRP A 503
ASN A 507
TYR A 529
CYH A 532
 0HK  A2000 (-3.2A)
0HK  A2000 (-2.8A)
0HK  A2000 (-4.3A)
0HK  A2000 (-4.3A)
0HK  A2000 (-2.9A)
0HK  A2000 (-4.1A)
0HK  A2000 (-3.9A)
 1.39A 4dajB-4u14A:
48.1		 4dajB-4u14A:
95.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 SER A 151
TRP A 503
TYR A 529
TYR A 533
CYH A 532
 0HK  A2000 (-3.3A)
0HK  A2000 (-4.3A)
0HK  A2000 (-4.1A)
None
0HK  A2000 (-3.9A)
 1.39A 4dajB-4u14A:
48.1		 4dajB-4u14A:
95.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u16 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		12 ASP A 147
TYR A 148
SER A 151
TRP A 199
THR A 231
THR A 234
ALA A 238
TRP A 503
TYR A 506
ASN A 507
TYR A 529
CYH A 532
 3C0  A1202 (-3.4A)
3C0  A1202 (-3.7A)
3C0  A1202 (-2.9A)
3C0  A1202 (-4.4A)
None
None
3C0  A1202 (-3.5A)
3C0  A1202 ( 4.0A)
3C0  A1202 (-3.7A)
3C0  A1202 (-2.9A)
3C0  A1202 (-3.7A)
3C0  A1202 (-3.6A)
 0.43A 4dajB-4u16A:
35.7		 4dajB-4u16A:
86.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u16 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 ASP A 147
TYR A 148
THR A 231
TRP A 503
ASN A 507
TYR A 529
CYH A 532
 3C0  A1202 (-3.4A)
3C0  A1202 (-3.7A)
None
3C0  A1202 ( 4.0A)
3C0  A1202 (-2.9A)
3C0  A1202 (-3.7A)
3C0  A1202 (-3.6A)
 1.33A 4dajB-4u16A:
35.7		 4dajB-4u16A:
86.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u16 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TYR A 148
THR A 231
ALA A 235
TYR A 529
CYH A 532
 3C0  A1202 (-3.7A)
None
3C0  A1202 (-3.5A)
3C0  A1202 (-3.7A)
3C0  A1202 (-3.6A)
 1.40A 4dajB-4u16A:
35.7		 4dajB-4u16A:
86.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cxv MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		10 ASP A 105
TYR A 106
SER A 109
THR A 189
ALA A 196
TRP A 378
TYR A 381
ASN A 382
TYR A 404
CYH A 407
 0HK  A 501 (-3.0A)
0HK  A 501 (-3.4A)
0HK  A 501 (-3.1A)
0HK  A 501 (-4.4A)
0HK  A 501 (-3.6A)
0HK  A 501 (-4.4A)
0HK  A 501 (-4.1A)
0HK  A 501 (-2.8A)
0HK  A 501 (-3.6A)
0HK  A 501 (-3.7A)
 0.59A 4dajB-5cxvA:
43.4		 4dajB-5cxvA:
74.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cxv MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 ASP A 105
TYR A 106
THR A 192
TRP A 378
ASN A 382
TYR A 404
CYH A 407
 0HK  A 501 (-3.0A)
0HK  A 501 (-3.4A)
0HK  A 501 (-4.0A)
0HK  A 501 (-4.4A)
0HK  A 501 (-2.8A)
0HK  A 501 (-3.6A)
0HK  A 501 (-3.7A)
 1.22A 4dajB-5cxvA:
43.4		 4dajB-5cxvA:
74.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cxv MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		11 ASP A 105
TYR A 106
TRP A 157
THR A 189
THR A 192
ALA A 196
TRP A 378
TYR A 381
ASN A 382
TYR A 404
CYH A 407
 0HK  A 501 (-3.0A)
0HK  A 501 (-3.4A)
0HK  A 501 (-4.0A)
0HK  A 501 (-4.4A)
0HK  A 501 (-4.0A)
0HK  A 501 (-3.6A)
0HK  A 501 (-4.4A)
0HK  A 501 (-4.1A)
0HK  A 501 (-2.8A)
0HK  A 501 (-3.6A)
0HK  A 501 (-3.7A)
 0.45A 4dajB-5cxvA:
43.4		 4dajB-5cxvA:
74.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		11 ASP A 112
TYR A 113
SER A 116
THR A 196
THR A 199
ALA A 203
TRP A 413
TYR A 416
ASN A 417
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
0HK  A1201 (-3.3A)
P6G  A1205 (-4.6A)
OLC  A1208 (-4.4A)
0HK  A1201 (-3.6A)
0HK  A1201 (-4.3A)
0HK  A1201 (-4.2A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 0.64A 4dajB-5dsgA:
42.1		 4dajB-5dsgA:
66.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 ASP A 112
TYR A 113
THR A 196
TRP A 413
ASN A 417
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
P6G  A1205 (-4.6A)
0HK  A1201 (-4.3A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 1.46A 4dajB-5dsgA:
42.1		 4dajB-5dsgA:
66.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		11 ASP A 112
TYR A 113
TRP A 164
THR A 196
THR A 199
ALA A 203
TRP A 413
TYR A 416
ASN A 417
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
OLC  A1208 ( 4.0A)
P6G  A1205 (-4.6A)
OLC  A1208 (-4.4A)
0HK  A1201 (-3.6A)
0HK  A1201 (-4.3A)
0HK  A1201 (-4.2A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 0.51A 4dajB-5dsgA:
42.1		 4dajB-5dsgA:
66.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TYR A 113
THR A 196
ALA A 200
TYR A 439
CYH A 442
 0HK  A1201 ( 3.2A)
P6G  A1205 (-4.6A)
0HK  A1201 ( 4.2A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 1.30A 4dajB-5dsgA:
42.1		 4dajB-5dsgA:
66.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpw PRO CATHEPSIN B S9

(Trypanosoma
congolense) 		PF00112
(Peptidase_C1) 		5 ASP A 239
THR A 259
THR A  47
ALA A  43
TYR A 248
 None
 1.42A 4dajB-5fpwA:
undetectable		 4dajB-5fpwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h20 -

(-) 		no annotation 5 SER A 102
THR A 212
THR A 211
ALA A 144
TYR A 276
 None
ASN  A 401 (-3.5A)
ASN  A 401 (-4.0A)
ASN  A 401 ( 4.3A)
ASN  A 401 ( 4.9A)
 1.13A 4dajB-6h20A:
0.2		 4dajB-6h20A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsf THYMIDYLATE SYNTHASE
A

(Bacillus
subtilis) 		PF00303
(Thymidylat_synt) 		3 ASN A 197
LEU A 264
PHE A   4
 None
 0.79A 4dajB-1bsfA:
undetectable		 4dajB-1bsfA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		3 ASN A 418
LEU A 375
PHE A 406
 None
 0.76A 4dajB-1d8cA:
0.0		 4dajB-1d8cA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg MOLECULAR CHAPERONE
DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		3 ASN D 314
LEU D 195
PHE D 356
 None
 0.82A 4dajB-1dkgD:
0.0		 4dajB-1dkgD:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drt CLAVAMINATE SYNTHASE
1

(Streptomyces
clavuligerus) 		PF02668
(TauD) 		3 ASN A 274
LEU A 255
PHE A 229
 None
 0.73A 4dajB-1drtA:
0.0		 4dajB-1drtA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		3 ASN A  76
LEU A 117
PHE A  29
 HEM  A 800 (-4.2A)
None
None
 0.60A 4dajB-1ehkA:
0.0		 4dajB-1ehkA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewr DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		3 ASN A 710
LEU A 572
PHE A 693
 None
 0.78A 4dajB-1ewrA:
0.0		 4dajB-1ewrA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTS, IRON-SULFUR
PROTEIN OF CARBON
MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		3 ASN A 134
LEU A  80
PHE A 115
 None
 0.73A 4dajB-1ffvA:
0.0		 4dajB-1ffvA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F

(Escherichia
coli) 		PF00267
(Porin_1) 		3 ASN A 252
LEU A 324
PHE A 250
 None
 0.79A 4dajB-1gfnA:
0.0		 4dajB-1gfnA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ASN A 395
LEU A 798
PHE A 259
 CA  A1100 (-3.8A)
None
None
 0.66A 4dajB-1h0hA:
0.0		 4dajB-1h0hA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7z ADENOVIRUS FIBRE
PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		3 ASN A 192
LEU A 305
PHE A 288
 None
 0.51A 4dajB-1h7zA:
undetectable		 4dajB-1h7zA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hng CD2

(Rattus rattus) 		PF05790
(C2-set)
PF07686
(V-set) 		3 ASN A  60
LEU A  89
PHE A  42
 None
 0.79A 4dajB-1hngA:
undetectable		 4dajB-1hngA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE

(Escherichia
coli) 		PF02374
(ArsA_ATPase) 		3 ASN A 235
LEU A   4
PHE A 276
 ADP  A 590 (-2.9A)
None
None
 0.72A 4dajB-1ii0A:
undetectable		 4dajB-1ii0A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ioo SF11-RNASE

(Nicotiana alata) 		PF00445
(Ribonuclease_T2) 		3 ASN A 173
LEU A  34
PHE A 178
 None
 0.66A 4dajB-1iooA:
undetectable		 4dajB-1iooA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdp ATRIAL NATRIURETIC
PEPTIDE CLEARANCE
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor) 		3 ASN A 243
LEU A 146
PHE A 241
 None
 0.80A 4dajB-1jdpA:
undetectable		 4dajB-1jdpA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeq KU70

(Homo sapiens) 		PF02037
(SAP)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		3 ASN A 171
LEU A 143
PHE A 169
 None
 0.81A 4dajB-1jeqA:
undetectable		 4dajB-1jeqA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		3 ASN A1303
LEU A1315
PHE A1289
 None
 0.80A 4dajB-1jl5A:
undetectable		 4dajB-1jl5A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkh MEVALONATE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 ASN A 270
LEU A 303
PHE A 274
 None
 0.71A 4dajB-1kkhA:
undetectable		 4dajB-1kkhA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5q SMALL NUCLEAR
RIBONUCLEOPROTEIN
HOMOLOG

(Pyrobaculum
aerophilum) 		no annotation 3 ASN A  46
LEU A  28
PHE A  64
 None
 0.76A 4dajB-1m5qA:
undetectable		 4dajB-1m5qA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5e SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF09272
(Hepsin-SRCR) 		3 ASN L  37
LEU L  86
PHE L 100
 None
 0.79A 4dajB-1o5eL:
undetectable		 4dajB-1o5eL:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p6s RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00169
(PH) 		3 ASN A  53
LEU A  78
PHE A  88
 None
 0.37A 4dajB-1p6sA:
undetectable		 4dajB-1p6sA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pho PHOSPHOPORIN

(Escherichia
coli) 		PF00267
(Porin_1) 		3 ASN A 252
LEU A 324
PHE A 250
 None
 0.77A 4dajB-1phoA:
undetectable		 4dajB-1phoA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfu PROTEIN
(IMMUNOGLOBULIN
IGG1-KAPPA ANTIBODY
(HEAVY CHAIN))

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASN H  60
LEU H  82
PHE H  37
 None
 0.79A 4dajB-1qfuH:
undetectable		 4dajB-1qfuH:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re0 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 1

(Saccharomyces
cerevisiae) 		PF01369
(Sec7) 		3 ASN B 145
LEU B 157
PHE B 143
 None
 0.81A 4dajB-1re0B:
undetectable		 4dajB-1re0B:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru1 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE

(Escherichia
coli) 		PF01288
(HPPK) 		3 ASN A 103
LEU A 128
PHE A 101
 None
 0.78A 4dajB-1ru1A:
undetectable		 4dajB-1ru1A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4f RNA-DEPENDENT RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		3 ASN A 556
LEU A 599
PHE A 549
 None
 0.72A 4dajB-1s4fA:
undetectable		 4dajB-1s4fA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t00 THIOREDOXIN

(Streptomyces
coelicolor) 		PF00085
(Thioredoxin) 		3 ASN A  60
LEU A   5
PHE A  28
 None
 0.69A 4dajB-1t00A:
undetectable		 4dajB-1t00A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT

(Bos taurus) 		PF04045
(P34-Arc) 		3 ASN D 242
LEU D 227
PHE D 121
 None
 0.73A 4dajB-1u2vD:
undetectable		 4dajB-1u2vD:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III

(Schizosaccharomyces
pombe) 		PF00291
(PALP) 		3 ASN A  49
LEU A 187
PHE A  45
 None
PLP  A 350 (-4.9A)
None
 0.73A 4dajB-1v71A:
undetectable		 4dajB-1v71A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc9 NDX1

(Thermus
thermophilus) 		PF00293
(NUDIX) 		3 ASN A  11
LEU A 121
PHE A  99
 None
 0.77A 4dajB-1vc9A:
undetectable		 4dajB-1vc9A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE

(Neisseria
gonorrhoeae) 		PF01128
(IspD) 		3 ASN A 104
LEU A  94
PHE A 170
 None
 0.79A 4dajB-1vgwA:
undetectable		 4dajB-1vgwA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		3 ASN A 519
LEU A 502
PHE A  65
 None
 0.81A 4dajB-1wacA:
undetectable		 4dajB-1wacA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvg CDP-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		3 ASN A 131
LEU A  74
PHE A  87
 None
 0.77A 4dajB-1wvgA:
undetectable		 4dajB-1wvgA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE

(Rattus
norvegicus) 		no annotation 3 ASN A 100
LEU A  33
PHE A  95
 None
 0.79A 4dajB-1xcjA:
undetectable		 4dajB-1xcjA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xew SMC PROTEIN

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		3 ASN X  41
LEU Y1095
PHE X  48
 None
 0.77A 4dajB-1xewX:
undetectable		 4dajB-1xewX:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE

(Salmonella
enterica) 		PF04223
(CitF) 		3 ASN A 361
LEU A 449
PHE A 264
 None
 0.68A 4dajB-1xr4A:
undetectable		 4dajB-1xr4A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Agrobacterium
tumefaciens) 		PF04095
(NAPRTase) 		3 ASN A 136
LEU A  80
PHE A  56
 None
 0.79A 4dajB-1ybeA:
undetectable		 4dajB-1ybeA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1

(Mus musculus) 		PF00104
(Hormone_recep) 		3 ASN A 451
LEU A 249
PHE A 274
 None
 0.80A 4dajB-1yp0A:
undetectable		 4dajB-1yp0A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		3 ASN A 520
LEU A 590
PHE A 581
 None
 0.81A 4dajB-1yvlA:
0.3		 4dajB-1yvlA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE

(Methanosarcina
barkeri) 		PF00296
(Bac_luciferase) 		3 ASN A 176
LEU A 295
PHE A 279
 F42  A 328 (-3.9A)
None
None
 0.71A 4dajB-1z69A:
undetectable		 4dajB-1z69A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zao RIO2 SERINE KINASE

(Archaeoglobus
fulgidus) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		3 ASN A  24
LEU A  51
PHE A  22
 None
 0.81A 4dajB-1zaoA:
undetectable		 4dajB-1zaoA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv6 EPB49 PROTEIN

(Homo sapiens) 		PF02209
(VHP)
PF16182
(AbLIM_anchor) 		3 ASN A  23
LEU A  29
PHE A  76
 None
 0.81A 4dajB-1zv6A:
undetectable		 4dajB-1zv6A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv6 EPB49 PROTEIN

(Homo sapiens) 		PF02209
(VHP)
PF16182
(AbLIM_anchor) 		3 ASN A  23
LEU A  42
PHE A  76
 None
 0.76A 4dajB-1zv6A:
undetectable		 4dajB-1zv6A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a39 ENDOGLUCANASE I

(Humicola
insolens) 		PF00840
(Glyco_hydro_7) 		3 ASN A  29
LEU A 146
PHE A  16
 None
 0.63A 4dajB-2a39A:
undetectable		 4dajB-2a39A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		3 ASN A 243
LEU A 330
PHE A 294
 None
 0.82A 4dajB-2braA:
undetectable		 4dajB-2braA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1l RESTRICTION
ENDONUCLEASE

(Bacillus firmus) 		PF13091
(PLDc_2) 		3 ASN A  46
LEU A  40
PHE A  44
 None
None
TLA  A1363 (-4.1A)
 0.64A 4dajB-2c1lA:
undetectable		 4dajB-2c1lA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		3 ASN A 556
LEU A 599
PHE A 549
 None
 0.81A 4dajB-2cjqA:
undetectable		 4dajB-2cjqA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASN A 242
LEU A 267
PHE A 246
 None
 0.82A 4dajB-2eu9A:
1.8		 4dajB-2eu9A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8a GLUTATHIONE
PEROXIDASE 1

(Homo sapiens) 		PF00255
(GSHPx) 		3 ASN A  87
LEU A  94
PHE A 110
 None
 0.78A 4dajB-2f8aA:
undetectable		 4dajB-2f8aA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2

(Homo sapiens) 		PF00378
(ECH_1) 		3 ASN A  27
LEU A 119
PHE A 260
 None
 0.82A 4dajB-2fw2A:
1.1		 4dajB-2fw2A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES

(Escherichia
coli) 		PF07995
(GSDH) 		3 ASN A  26
LEU A 106
PHE A  22
 None
EDO  A3016 (-4.6A)
EDO  A3020 (-4.7A)
 0.60A 4dajB-2g8sA:
undetectable		 4dajB-2g8sA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gti REPLICASE
POLYPROTEIN 1AB

(Murine
coronavirus) 		PF06471
(NSP11) 		3 ASN A  45
LEU A   2
PHE A  58
 None
None
GOL  A 601 ( 4.3A)
 0.76A 4dajB-2gtiA:
undetectable		 4dajB-2gtiA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3y EPIDIDYMAL SECRETORY
GLUTATHIONE
PEROXIDASE

(Homo sapiens) 		PF00255
(GSHPx) 		3 ASN A 112
LEU A 119
PHE A 135
 None
 0.71A 4dajB-2i3yA:
undetectable		 4dajB-2i3yA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i8b MINOR NUCLEOPROTEIN
VP30

(Zaire
ebolavirus) 		PF11507
(Transcript_VP30) 		3 ASN A 244
LEU A 199
PHE A 242
 None
 0.67A 4dajB-2i8bA:
undetectable		 4dajB-2i8bA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iun AVIAN ADENOVIRUS
CELO LONG FIBRE

(Fowl
aviadenovirus A) 		PF16812
(AdHead_fibreRBD) 		3 ASN A 666
LEU A 699
PHE A 601
 None
 0.78A 4dajB-2iunA:
undetectable		 4dajB-2iunA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASN A 311
LEU A 294
PHE A 356
 None
 0.70A 4dajB-2jiiA:
undetectable		 4dajB-2jiiA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxc EPIDERMAL GROWTH
FACTOR RECEPTOR
SUBSTRATE 15
STONIN-2

(Homo sapiens) 		PF12016
(Stonin2_N)
PF12763
(EF-hand_4) 		3 ASN B 329
LEU A 165
PHE B 334
 None
 0.82A 4dajB-2jxcB:
undetectable		 4dajB-2jxcB:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kb2 BLRP1

(Klebsiella
pneumoniae) 		PF04940
(BLUF) 		3 ASN A  46
LEU A  26
PHE A  51
 None
FMN  A 149 (-4.0A)
None
 0.58A 4dajB-2kb2A:
undetectable		 4dajB-2kb2A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kjh UBIQUITIN/ISG15-CONJ
UGATING ENZYME E2 L6

(Homo sapiens) 		PF00179
(UQ_con) 		3 ASN A 112
LEU A  86
PHE A  50
 None
 0.76A 4dajB-2kjhA:
undetectable		 4dajB-2kjhA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lav VACCINIA-RELATED
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASN A 182
LEU A 165
PHE A 227
 None
 0.82A 4dajB-2lavA:
3.0		 4dajB-2lavA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mjl PEPTIDYL-TRNA
HYDROLASE

(Vibrio cholerae) 		PF01195
(Pept_tRNA_hydro) 		3 ASN A  72
LEU A  12
PHE A  49
 None
 0.73A 4dajB-2mjlA:
undetectable		 4dajB-2mjlA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n00 INTERFERON-INDUCIBLE
PROTEIN AIM2

(Mus musculus) 		PF02758
(PYRIN) 		3 ASN A  73
LEU A  48
PHE A  28
 None
 0.64A 4dajB-2n00A:
undetectable		 4dajB-2n00A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7l TROPONIN C/TROPONIN
I CHIMERA

(Homo sapiens) 		PF13833
(EF-hand_8) 		3 ASN C  18
LEU C 111
PHE C  20
 None
 0.81A 4dajB-2n7lC:
4.4		 4dajB-2n7lC:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 ASN A1011
LEU A 974
PHE A 922
 None
 0.77A 4dajB-2np0A:
undetectable		 4dajB-2np0A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		3 ASN A 400
LEU A 406
PHE A 398
 None
 0.74A 4dajB-2nyfA:
2.4		 4dajB-2nyfA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oej 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Geobacillus
kaustophilus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ASN A 239
LEU A 289
PHE A 267
 None
 0.80A 4dajB-2oejA:
undetectable		 4dajB-2oejA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oh1 ACETYLTRANSFERASE,
GNAT FAMILY

(Listeria
monocytogenes) 		no annotation 3 ASN A  27
LEU A  68
PHE A  52
 None
 0.74A 4dajB-2oh1A:
undetectable		 4dajB-2oh1A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pun METHYLTHIORIBOSE
KINASE

(Bacillus
subtilis) 		PF01636
(APH) 		3 ASN A 207
LEU A 368
PHE A 187
 None
 0.75A 4dajB-2punA:
undetectable		 4dajB-2punA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		3 ASN A 199
LEU A 253
PHE A 215
 None
 0.76A 4dajB-2q3rA:
undetectable		 4dajB-2q3rA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r37 GLUTATHIONE
PEROXIDASE 3

(Homo sapiens) 		PF00255
(GSHPx) 		3 ASN A 112
LEU A 119
PHE A 135
 None
 0.73A 4dajB-2r37A:
undetectable		 4dajB-2r37A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcy PYRROLINE
CARBOXYLATE
REDUCTASE

(Plasmodium
falciparum) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		3 ASN A 142
LEU A  86
PHE A 125
 None
 0.79A 4dajB-2rcyA:
undetectable		 4dajB-2rcyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASN A 182
LEU A 165
PHE A 227
 None
 0.64A 4dajB-2rsvA:
3.1		 4dajB-2rsvA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo sapiens) 		PF00878
(CIMR) 		3 ASN A1743
LEU A1663
PHE A1787
 None
 0.77A 4dajB-2v5nA:
undetectable		 4dajB-2v5nA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		3 ASN A 371
LEU A 807
PHE A 367
 None
 0.69A 4dajB-2vcaA:
undetectable		 4dajB-2vcaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		3 ASN A 528
LEU A 466
PHE A 701
 None
 0.68A 4dajB-2wghA:
undetectable		 4dajB-2wghA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB

(Salmonella
enterica) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		3 ASN A  82
LEU A 333
PHE A  48
 None
 0.74A 4dajB-2wnwA:
undetectable		 4dajB-2wnwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 ASN A  25
LEU A 112
PHE A  68
 None
 0.71A 4dajB-2wtbA:
undetectable		 4dajB-2wtbA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 ASN A 317
LEU A 338
PHE A 837
 None
GOL  A 904 (-4.7A)
None
 0.74A 4dajB-2wyhA:
1.9		 4dajB-2wyhA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1f MRNA
3'-END-PROCESSING
PROTEIN RNA15

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		3 ASN A  80
LEU A  37
PHE A  88
 None
 0.71A 4dajB-2x1fA:
undetectable		 4dajB-2x1fA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 ASN A 297
LEU A 185
PHE A 249
 None
 0.80A 4dajB-2x3kA:
undetectable		 4dajB-2x3kA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ASN A 484
LEU A 190
PHE A 509
 None
 0.68A 4dajB-2xf2A:
undetectable		 4dajB-2xf2A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynp COATOMER SUBUNIT
BETA'

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		3 ASN A 389
LEU A 352
PHE A 370
 None
 0.79A 4dajB-2ynpA:
undetectable		 4dajB-2ynpA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzj 167AA LONG
HYPOTHETICAL DUTPASE

(Sulfurisphaera
tokodaii) 		PF00692
(dUTPase) 		3 ASN A 124
LEU A 144
PHE A  81
 None
 0.77A 4dajB-2yzjA:
undetectable		 4dajB-2yzjA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC

(Mycobacterium
tuberculosis) 		PF00903
(Glyoxalase) 		3 ASN A 113
LEU A   6
PHE A 204
 None
 0.57A 4dajB-2zi8A:
undetectable		 4dajB-2zi8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE

(Pseudomonas sp.
ATCC 19121) 		PF00155
(Aminotran_1_2) 		3 ASN A 306
LEU A 185
PHE A 249
 None
 0.77A 4dajB-2zy2A:
undetectable		 4dajB-2zy2A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		3 ASN A 279
LEU A 248
PHE A 285
 None
 0.67A 4dajB-3agrA:
undetectable		 4dajB-3agrA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		3 ASN B 308
LEU B 304
PHE B  57
 None
 0.81A 4dajB-3aqcB:
undetectable		 4dajB-3aqcB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9n ALKANE MONOOXYGENASE

(Geobacillus
thermodenitrificans) 		PF00296
(Bac_luciferase) 		3 ASN A 376
LEU A 416
PHE A  51
 None
 0.76A 4dajB-3b9nA:
undetectable		 4dajB-3b9nA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT

(Methanosarcina
barkeri) 		PF02552
(CO_dh) 		3 ASN G  86
LEU G 102
PHE G  92
 None
 0.74A 4dajB-3cf4G:
undetectable		 4dajB-3cf4G:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 ASN A 153
LEU A 149
PHE A  51
 None
 0.73A 4dajB-3cmgA:
undetectable		 4dajB-3cmgA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25

(Homo sapiens) 		PF05871
(ESCRT-II) 		3 ASN C 121
LEU C 130
PHE C 176
 None
 0.66A 4dajB-3cuqC:
undetectable		 4dajB-3cuqC:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr0 CYTOCHROME C6

(Synechococcus
sp. PCC 7002) 		PF13442
(Cytochrome_CBB3) 		3 ASN A  60
LEU A  40
PHE A  68
 None
HEM  A  94 ( 4.1A)
HEM  A  94 (-3.6A)
 0.80A 4dajB-3dr0A:
undetectable		 4dajB-3dr0A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efz 14-3-3 PROTEIN

(Cryptosporidium
parvum) 		PF00244
(14-3-3) 		3 ASN A 212
LEU A 263
PHE A 219
 None
 0.74A 4dajB-3efzA:
1.9		 4dajB-3efzA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Saccharomyces
cerevisiae) 		PF08311
(Mad3_BUB1_I) 		3 ASN A 121
LEU A 152
PHE A 118
 None
 0.81A 4dajB-3eslA:
undetectable		 4dajB-3eslA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frn FLAGELLAR PROTEIN
FLGA

(Thermotoga
maritima) 		PF13144
(ChapFlgA) 		3 ASN A 151
LEU A  56
PHE A 137
 None
 0.78A 4dajB-3frnA:
undetectable		 4dajB-3frnA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg0 KLEBSIELLA
PNEUMONIAE BLRP1

(Klebsiella
pneumoniae) 		PF00563
(EAL)
PF04940
(BLUF) 		3 ASN A  43
LEU A  20
PHE A  48
 None
 0.81A 4dajB-3gg0A:
undetectable		 4dajB-3gg0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkj NIEMANN-PICK C1
PROTEIN

(Homo sapiens) 		PF16414
(NPC1_N) 		3 ASN A 103
LEU A 173
PHE A 101
 None
 0.81A 4dajB-3gkjA:
undetectable		 4dajB-3gkjA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h79 THIOREDOXIN-LIKE
PROTEIN

(Trypanosoma
cruzi) 		PF00085
(Thioredoxin) 		3 ASN A 126
LEU A  58
PHE A 124
 None
 0.61A 4dajB-3h79A:
undetectable		 4dajB-3h79A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE

(Clostridium
acetobutylicum) 		PF00730
(HhH-GPD)
PF07934
(OGG_N) 		3 ASN A 288
LEU A 251
PHE A 282
 None
 0.80A 4dajB-3i0wA:
undetectable		 4dajB-3i0wA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Colwellia
psychrerythraea) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 ASN A 312
LEU A 276
PHE A 306
 NA  A 491 (-2.6A)
None
None
 0.78A 4dajB-3ic9A:
undetectable		 4dajB-3ic9A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T

(Saccharomyces
cerevisiae) 		PF00149
(Metallophos)
PF08321
(PPP5) 		3 ASN A 259
LEU A 204
PHE A 261
 None
 0.78A 4dajB-3icfA:
undetectable		 4dajB-3icfA:
19.76