SIMILAR PATTERNS OF AMINO ACIDS FOR 4D7B_B_TCWB1126_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 LEU A 561
ALA A 546
SER A 529
THR A 527
 None
 0.68A 4d7bA-1e8tA:
undetectable		 4d7bA-1e8tA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f80 HOLO-(ACYL CARRIER
PROTEIN) SYNTHASE

(Bacillus
subtilis) 		PF01648
(ACPS) 		4 LEU A   7
ALA A 111
SER A 102
THR A 104
 None
None
None
NA  A1255 (-3.8A)
 0.86A 4d7bA-1f80A:
undetectable		 4d7bA-1f80A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 LEU A 506
ALA A 563
LEU A 565
THR A 576
 None
 0.48A 4d7bA-1g0dA:
undetectable		 4d7bA-1g0dA:
14.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		5 LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
 None
 0.79A 4d7bA-1gkeA:
22.0		 4d7bA-1gkeA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
THR A 119
 None
 0.81A 4d7bA-1gkeA:
22.0		 4d7bA-1gkeA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gut MOLYBDATE BINDING
PROTEIN II

(Clostridium
pasteurianum) 		PF03459
(TOBE) 		4 LYS A  18
LEU A  16
ALA A  23
SER A  37
 None
 0.82A 4d7bA-1gutA:
undetectable		 4d7bA-1gutA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		4 LEU A 120
ALA A 116
SER A 167
THR A 113
 None
 0.94A 4d7bA-1hjuA:
undetectable		 4d7bA-1hjuA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747

(Methanothermobacter
thermautotrophicus) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		4 LEU A 183
ALA A 179
LEU A 185
THR A 176
 None
 0.98A 4d7bA-1i36A:
undetectable		 4d7bA-1i36A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		4 LEU A  94
ALA A  90
LEU A  96
THR A  87
 None
 0.80A 4d7bA-1j0aA:
undetectable		 4d7bA-1j0aA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 LEU A 585
ALA A 291
LEU A 293
THR A 305
 None
 0.76A 4d7bA-1k25A:
undetectable		 4d7bA-1k25A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 LEU A 361
ALA A 357
LEU A 363
THR A 354
 None
 0.80A 4d7bA-1l5jA:
undetectable		 4d7bA-1l5jA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5x SURVIVAL PROTEIN E

(Pyrobaculum
aerophilum) 		PF01975
(SurE) 		4 THR A  73
ALA A 111
LEU A 109
SER A 106
 None
 0.91A 4d7bA-1l5xA:
undetectable		 4d7bA-1l5xA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no7 MAJOR CAPSID PROTEIN

(Human
alphaherpesvirus
1) 		PF03122
(Herpes_MCP) 		5 LEU A 994
THR A 905
ALA A 907
LEU A 909
SER A 757
 None
 1.25A 4d7bA-1no7A:
undetectable		 4d7bA-1no7A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		4 THR A  74
LEU A 224
SER A  64
THR A  32
 None
 0.94A 4d7bA-1pbyA:
undetectable		 4d7bA-1pbyA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhv PROTEIN (ADENOVIRUS
FIBRE)

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob) 		4 THR A 435
ALA A 437
LEU A 439
THR A 422
 None
 0.83A 4d7bA-1qhvA:
undetectable		 4d7bA-1qhvA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qiu ADENOVIRUS FIBRE

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob)
PF00608
(Adeno_shaft) 		4 THR A 435
ALA A 437
LEU A 439
THR A 422
 None
 0.95A 4d7bA-1qiuA:
undetectable		 4d7bA-1qiuA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT

(Thauera
aromatica) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.79A 4d7bA-1sb3B:
undetectable		 4d7bA-1sb3B:
17.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		5 LEU A  17
THR A 106
ALA A 108
LEU A 110
THR A 119
 None
 0.54A 4d7bA-1sn2A:
20.9		 4d7bA-1sn2A:
53.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
 None
 0.90A 4d7bA-1sn2A:
20.9		 4d7bA-1sn2A:
53.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4n RIBONUCLEASE III

(Saccharomyces
cerevisiae) 		PF00035
(dsrm) 		4 LYS A 443
ALA A 446
LEU A 377
SER A 376
 None
 0.97A 4d7bA-1t4nA:
undetectable		 4d7bA-1t4nA:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		6 LEU A  17
THR A 106
ALA A 108
LEU A 110
SER A 117
THR A 119
 None
 0.67A 4d7bA-1tfpA:
19.6		 4d7bA-1tfpA:
73.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
 None
 0.97A 4d7bA-1tfpA:
19.6		 4d7bA-1tfpA:
73.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE

(Staphylococcus
aureus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 LYS A   2
ALA A 170
SER A 315
THR A 317
 None
 0.80A 4d7bA-1tvzA:
undetectable		 4d7bA-1tvzA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uun MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		4 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.64A 4d7bA-1uunA:
undetectable		 4d7bA-1uunA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		4 LEU A 359
ALA A 355
LEU A 361
THR A 352
 None
 0.94A 4d7bA-1v4aA:
undetectable		 4d7bA-1v4aA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8h SULFUR OXIDATION
PROTEIN SOXZ

(Thermus
thermophilus) 		PF08770
(SoxZ) 		4 LEU A  22
THR A   5
ALA A   7
LEU A   9
 None
 0.93A 4d7bA-1v8hA:
1.5		 4d7bA-1v8hA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcd MAJOR STRUCTURAL
PROTEIN VP2

(Infectious
bursal disease
virus) 		PF01766
(Birna_VP2) 		4 THR J 336
ALA J 334
SER J 332
THR J 207
 None
 0.79A 4d7bA-1wcdJ:
undetectable		 4d7bA-1wcdJ:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcd MAJOR STRUCTURAL
PROTEIN VP2

(Infectious
bursal disease
virus) 		PF01766
(Birna_VP2) 		4 THR J 364
ALA J 366
SER J 105
THR J 107
 None
 0.63A 4d7bA-1wcdJ:
undetectable		 4d7bA-1wcdJ:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE

(Escherichia
coli) 		PF00171
(Aldedh) 		4 LEU A 171
ALA A 146
SER A 221
THR A 223
 None
None
None
NAI  A1001 (-4.5A)
 0.90A 4d7bA-1wnbA:
undetectable		 4d7bA-1wnbA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 THR A 666
ALA A 664
SER A 662
THR A 627
 None
None
IOD  A9040 (-3.0A)
None
 0.96A 4d7bA-1xc6A:
undetectable		 4d7bA-1xc6A:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yht DSPB

(Aggregatibacter
actinomycetemcomitans) 		PF00728
(Glyco_hydro_20) 		4 LEU A 277
ALA A 325
LEU A 327
THR A  19
 None
 0.80A 4d7bA-1yhtA:
undetectable		 4d7bA-1yhtA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cum TENASCIN-X

(Homo sapiens) 		PF00041
(fn3) 		4 LEU A  40
ALA A  74
LEU A  76
THR A  90
 None
 0.72A 4d7bA-2cumA:
2.8		 4d7bA-2cumA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f28 SIALIDASE 2

(Homo sapiens) 		PF13088
(BNR_2) 		4 LEU A 294
ALA A 309
LEU A 311
SER A 322
 None
 0.84A 4d7bA-2f28A:
undetectable		 4d7bA-2f28A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3j RNA AND EXPORT
FACTOR BINDING
PROTEIN 2

(Mus musculus) 		PF00076
(RRM_1)
PF07078
(FYTT) 		4 LEU A 149
THR A  73
ALA A  75
LEU A  77
 None
 0.89A 4d7bA-2f3jA:
undetectable		 4d7bA-2f3jA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE

(Bifidobacterium
adolescentis) 		PF00128
(Alpha-amylase)
PF09244
(DUF1964) 		4 LEU A 463
ALA A 480
LEU A 482
SER A 493
 None
 0.91A 4d7bA-2gduA:
undetectable		 4d7bA-2gduA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20

(Saccharomyces
cerevisiae) 		PF08612
(Med20) 		4 LYS A 123
LEU A 121
SER A  59
THR A  61
 None
 0.84A 4d7bA-2hzsA:
undetectable		 4d7bA-2hzsA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ice COMPLEMENT C3 BETA
CHAIN

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 LEU A 266
THR A 246
SER A 305
THR A 307
 None
 0.89A 4d7bA-2iceA:
4.1		 4d7bA-2iceA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K

(Homo sapiens) 		PF00481
(PP2C) 		4 LEU A 201
THR A 191
ALA A 193
LEU A 195
 None
 0.67A 4d7bA-2iq1A:
undetectable		 4d7bA-2iq1A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5

(Mus musculus) 		PF00400
(WD40) 		4 LEU B 187
THR B 176
ALA B 178
THR B 170
 None
 0.99A 4d7bA-2pbiB:
undetectable		 4d7bA-2pbiB:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfc HYPOTHETICAL PROTEIN
RV0098/MT0107

(Mycobacterium
tuberculosis) 		PF10862
(FcoT) 		4 LEU A 141
LEU A  54
SER A  47
THR A  49
 None
 0.83A 4d7bA-2pfcA:
undetectable		 4d7bA-2pfcA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v72 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		4 THR A  66
ALA A  64
SER A  62
THR A 105
 None
 0.89A 4d7bA-2v72A:
1.6		 4d7bA-2v72A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 LEU B 363
THR B 415
ALA B 391
LEU B 367
 None
 0.97A 4d7bA-2v9tB:
undetectable		 4d7bA-2v9tB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9u MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		4 LEU A  62
ALA A 164
LEU A 166
THR A 176
 LEU  A  62 ( 0.5A)
ALA  A 164 ( 0.0A)
LEU  A 166 ( 0.5A)
THR  A 176 ( 0.8A)
 0.67A 4d7bA-2v9uA:
3.2		 4d7bA-2v9uA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN

(Nostoc
punctiforme) 		PF00350
(Dynamin_N) 		4 LEU A  49
ALA A  38
LEU A  51
THR A  34
 None
 0.89A 4d7bA-2w6dA:
undetectable		 4d7bA-2w6dA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2

(Bacillus
subtilis) 		PF00884
(Sulfatase) 		4 LYS A 363
THR A 338
ALA A 340
THR A 404
 PG4  A1637 (-2.8A)
None
None
None
 0.94A 4d7bA-2w8dA:
undetectable		 4d7bA-2w8dA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Homo sapiens) 		PF00133
(tRNA-synt_1) 		5 LEU A 269
THR A 293
ALA A 291
LEU A 289
THR A 386
 None
 1.37A 4d7bA-2wfdA:
undetectable		 4d7bA-2wfdA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wua ACETOACETYL COA
THIOLASE

(Helianthus
annuus) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A  77
LEU A 163
SER A 102
THR A 131
 None
 0.98A 4d7bA-2wuaA:
undetectable		 4d7bA-2wuaA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvf PUTATIVE
NICKEL-RESPONSIVE
REGULATOR

(Helicobacter
pylori) 		PF01402
(RHH_1)
PF08753
(NikR_C) 		4 LYS A 140
LEU A 138
ALA A  66
LEU A  68
 None
 0.65A 4d7bA-2wvfA:
undetectable		 4d7bA-2wvfA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 LEU A 722
THR A 704
ALA A 702
LEU A 700
 None
 0.82A 4d7bA-2x05A:
undetectable		 4d7bA-2x05A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 LEU A1123
ALA A1225
LEU A1222
THR A1224
 None
 0.95A 4d7bA-2xt6A:
undetectable		 4d7bA-2xt6A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 LEU B 585
ALA B 291
LEU B 293
THR B 305
 None
 0.76A 4d7bA-2z2mB:
undetectable		 4d7bA-2z2mB:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zch MONOCLONAL ANTIBODY
8G8F5 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LYS H 205
ALA H 198
SER H 149
THR H 151
 None
 0.85A 4d7bA-2zchH:
undetectable		 4d7bA-2zchH:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 THR A 143
ALA A 252
SER A 250
THR A 145
 None
 0.99A 4d7bA-3actA:
undetectable		 4d7bA-3actA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 LEU A  36
THR A  20
ALA A  24
LEU A  28
 None
 0.96A 4d7bA-3bqyA:
undetectable		 4d7bA-3bqyA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF14587
(Glyco_hydr_30_2) 		4 LEU A 450
THR A 463
ALA A 465
SER A 513
 None
 0.64A 4d7bA-3clwA:
undetectable		 4d7bA-3clwA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX

(Escherichia
coli) 		PF03320
(FBPase_glpX) 		4 ALA A 102
LEU A 104
SER A 281
THR A 283
 None
 0.73A 4d7bA-3d1rA:
undetectable		 4d7bA-3d1rA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3duz MAJOR ENVELOPE
GLYCOPROTEIN

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF03273
(Baculo_gp64) 		4 LYS A  49
LEU A  47
ALA A 227
LEU A 229
 None
 0.80A 4d7bA-3duzA:
undetectable		 4d7bA-3duzA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)

(Escherichia
coli;
Homo sapiens) 		PF00085
(Thioredoxin) 		4 LYS A 426
LEU A 424
ALA A 366
LEU A 368
 None
 0.79A 4d7bA-3dxbA:
undetectable		 4d7bA-3dxbA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e54 RRNA INTRON-ENCODED
ENDONUCLEASE

(Vulcanisaeta
distributa) 		PF00961
(LAGLIDADG_1) 		4 LEU A  38
ALA A 133
SER A  23
THR A 137
 None
 0.95A 4d7bA-3e54A:
undetectable		 4d7bA-3e54A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8u TAPASIN

(Homo sapiens) 		PF07654
(C1-set) 		4 ALA B 163
LEU B 142
SER B 161
THR B 231
 None
None
NAG  B1233 ( 4.6A)
None
 0.84A 4d7bA-3f8uB:
3.8		 4d7bA-3f8uB:
14.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
LEU A 110
SER A 117
THR A 119
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
 0.73A 4d7bA-3fc8A:
23.7		 4d7bA-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
THR A 119
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
 0.22A 4d7bA-3fc8A:
23.7		 4d7bA-3fc8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE

(Rhodopseudomonas
palustris) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 LEU P 102
THR P 106
ALA P   7
LEU P   5
 None
FAD  P 449 (-4.1A)
FAD  P 449 ( 4.7A)
None
 0.97A 4d7bA-3fg2P:
undetectable		 4d7bA-3fg2P:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214

(Homo sapiens) 		PF12894
(ANAPC4_WD40) 		4 ALA A 175
LEU A 169
SER A 173
THR A 188
 None
 0.95A 4d7bA-3fhcA:
undetectable		 4d7bA-3fhcA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214

(Homo sapiens) 		PF12894
(ANAPC4_WD40) 		4 LEU A 144
ALA A 175
SER A 173
THR A 188
 None
 0.96A 4d7bA-3fhcA:
undetectable		 4d7bA-3fhcA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III

(Burkholderia
pseudomallei) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A  86
THR A 150
ALA A 148
LEU A 146
 None
 0.75A 4d7bA-3gweA:
undetectable		 4d7bA-3gweA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwm HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Mycolicibacterium
smegmatis) 		PF01648
(ACPS) 		4 THR A 120
ALA A 122
SER A 113
THR A 115
 THR  A 120 ( 0.8A)
ALA  A 122 ( 0.0A)
SER  A 113 ( 0.0A)
THR  A 115 (-0.8A)
 0.82A 4d7bA-3gwmA:
undetectable		 4d7bA-3gwmA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		4 LYS A  81
LEU A  79
ALA A  88
LEU A  90
 None
 0.83A 4d7bA-3h39A:
undetectable		 4d7bA-3h39A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdi PROCESSING PROTEASE

(Bacillus
halodurans) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU A 400
ALA A 235
LEU A 237
THR A 302
 None
 0.73A 4d7bA-3hdiA:
undetectable		 4d7bA-3hdiA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpd HYDROXYETHYLTHIAZOLE
KINASE

(Pyrococcus
horikoshii) 		PF02110
(HK) 		4 LEU A 246
THR A  29
ALA A  33
LEU A  37
 None
 0.89A 4d7bA-3hpdA:
undetectable		 4d7bA-3hpdA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i44 ALDEHYDE
DEHYDROGENASE

(Bartonella
henselae) 		PF00171
(Aldedh) 		4 LEU A 173
LEU A 146
SER A 224
THR A 226
 None
 0.88A 4d7bA-3i44A:
undetectable		 4d7bA-3i44A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Haemophilus
influenzae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LYS A  54
THR A 125
ALA A 127
LEU A 129
 None
 0.88A 4d7bA-3ic1A:
undetectable		 4d7bA-3ic1A:
15.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iwu 5-HYDROXYISOURATE
HYDROLASE

(Danio rerio) 		PF00576
(Transthyretin) 		4 LEU A  14
LEU A 107
SER A 114
THR A 116
 None
 0.88A 4d7bA-3iwuA:
19.7		 4d7bA-3iwuA:
33.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 A223 PENTON BASE

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 4 ALA Q 215
LEU Q 217
SER Q 165
THR Q 167
 None
 0.91A 4d7bA-3j31Q:
undetectable		 4d7bA-3j31Q:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 4 LEU A  11
THR A  92
ALA A  94
THR A 218
 None
 0.73A 4d7bA-3j4uA:
undetectable		 4d7bA-3j4uA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Coxiella
burnetii) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 LEU A 324
ALA A 198
SER A 202
THR A 199
 None
 0.89A 4d7bA-3k96A:
undetectable		 4d7bA-3k96A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7

(Streptomyces
avermitilis) 		PF03259
(Robl_LC7) 		4 LEU A  89
ALA A 101
LEU A 103
SER A  29
 None
 0.74A 4d7bA-3kyeA:
undetectable		 4d7bA-3kyeA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7

(Streptomyces
avermitilis) 		PF03259
(Robl_LC7) 		4 LEU A 100
ALA A  30
LEU A  32
SER A  41
 None
 0.75A 4d7bA-3kyeA:
undetectable		 4d7bA-3kyeA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C

(Streptococcus
mutans) 		PF08282
(Hydrolase_3) 		4 LEU A 134
ALA A 106
SER A 108
THR A 152
 None
 0.98A 4d7bA-3l7yA:
undetectable		 4d7bA-3l7yA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4x MONOPOLIN COMPLEX
SUBUNIT CSM1

(Saccharomyces
cerevisiae) 		PF12539
(Csm1) 		4 LYS A 119
ALA A 135
SER A 162
THR A 160
 None
 0.88A 4d7bA-3n4xA:
undetectable		 4d7bA-3n4xA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 111
LEU A 113
LEU A 155
THR A 148
 SO4  A   5 (-2.8A)
None
None
SO4  A 369 (-3.7A)
 0.79A 4d7bA-3nuuA:
undetectable		 4d7bA-3nuuA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pei CYTOSOL
AMINOPEPTIDASE

(Francisella
tularensis) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 LEU A 290
ALA A 286
LEU A 292
THR A 283
 EDO  A 491 (-4.2A)
None
None
None
 0.93A 4d7bA-3peiA:
undetectable		 4d7bA-3peiA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H

(Human
gammaherpesvirus
4) 		no annotation 4 LEU A 351
ALA A 104
LEU A 348
SER A 345
 None
 0.92A 4d7bA-3phfA:
undetectable		 4d7bA-3phfA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjx CYCLIC DIMERIC GMP
BINDING PROTEIN

(Pseudomonas
fluorescens) 		PF00563
(EAL)
PF00990
(GGDEF) 		4 LEU A 269
ALA A 323
LEU A 325
THR A 315
 None
 0.73A 4d7bA-3pjxA:
undetectable		 4d7bA-3pjxA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 LEU B 280
LEU B 264
SER B 317
THR B 319
 None
 0.87A 4d7bA-3prxB:
3.5		 4d7bA-3prxB:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz6 LEUCYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00133
(tRNA-synt_1) 		5 LEU A 266
THR A 336
ALA A 334
LEU A 332
THR A 431
 None
 1.39A 4d7bA-3pz6A:
undetectable		 4d7bA-3pz6A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlb ENANTIO-PYOCHELIN
RECEPTOR

(Pseudomonas
fluorescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 LEU A 524
THR A 497
ALA A 499
SER A 478
 None
 0.95A 4d7bA-3qlbA:
undetectable		 4d7bA-3qlbA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsi NIKR
NICKEL-RESPONSIVE
REGULATOR

(Helicobacter
pylori) 		no annotation 4 LYS B 140
LEU B 138
ALA B  66
LEU B  68
 None
 0.69A 4d7bA-3qsiB:
undetectable		 4d7bA-3qsiB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE

(Bacteroides
thetaiotaomicron) 		PF00348
(polyprenyl_synt) 		4 LEU A  74
THR A 127
ALA A  70
THR A  67
 None
 0.94A 4d7bA-3rmgA:
undetectable		 4d7bA-3rmgA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sag EXOSOME COMPONENT 10

(Homo sapiens) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 LEU A 396
ALA A 392
LEU A 398
THR A 389
 LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
 0.83A 4d7bA-3sagA:
undetectable		 4d7bA-3sagA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY

(Sphaerobacter
thermophilus) 		PF01380
(SIS) 		5 LEU A 215
THR A 235
ALA A 233
LEU A 231
THR A 115
 None
 1.49A 4d7bA-3shoA:
undetectable		 4d7bA-3shoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sma FRBF

(Streptomyces
rubellomurinus) 		PF02522
(Antibiotic_NAT) 		4 LEU A 180
ALA A 258
LEU A 260
SER A 249
 None
 0.64A 4d7bA-3smaA:
undetectable		 4d7bA-3smaA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		5 LEU A  55
THR A  62
ALA A  58
LEU A  54
SER A  14
 None
 1.26A 4d7bA-3ts7A:
undetectable		 4d7bA-3ts7A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 LEU A 484
ALA A 498
SER A 695
THR A 500
 None
 0.92A 4d7bA-3ttfA:
undetectable		 4d7bA-3ttfA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		4 LEU A 169
LEU A 142
SER A 220
THR A 222
 None
 0.88A 4d7bA-3ty7A:
undetectable		 4d7bA-3ty7A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vot L-AMINO ACID LIGASE,
BL00235

(Bacillus
licheniformis) 		PF13535
(ATP-grasp_4) 		4 LEU A  97
ALA A  93
LEU A  99
THR A  90
 None
 0.88A 4d7bA-3votA:
undetectable		 4d7bA-3votA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		5 LEU A 674
THR A  93
LEU A 861
SER A 862
THR A 859
 None
 1.48A 4d7bA-3w9iA:
undetectable		 4d7bA-3w9iA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 LEU B1171
ALA B1047
LEU B1049
SER B1249
 None
 0.88A 4d7bA-3zefB:
undetectable		 4d7bA-3zefB:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 LEU A1123
ALA A1225
LEU A1222
THR A1224
 None
 0.97A 4d7bA-3zhrA:
undetectable		 4d7bA-3zhrA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		4 THR A 154
ALA A 148
LEU A 146
SER A 143
 None
 0.97A 4d7bA-4a0hA:
undetectable		 4d7bA-4a0hA:
10.04