SIMILAR PATTERNS OF AMINO ACIDS FOR 4D39_B_ACTB860

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dci DIENOYL-COA
ISOMERASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 GLY A 172
ILE A 171
GLN A 193
VAL A 199
 None
None
SO4  A  14 (-3.2A)
None
 0.85A 4d39B-1dciA:
0.1		 4d39B-1dciA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		4 GLY A  38
ILE A  39
GLN A  37
TRP A 215
 None
 1.00A 4d39B-1hl2A:
0.0		 4d39B-1hl2A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 GLY A 546
ILE A 544
VAL A 578
SER A 574
 None
 1.13A 4d39B-1hwwA:
0.0		 4d39B-1hwwA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jro XANTHINE
DEHYDROGENASE, CHAIN
A

(Rhodobacter
capsulatus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		4 GLY A 205
ILE A 202
TRP A 211
VAL A 212
 FAD  A3005 (-3.3A)
None
None
None
 1.09A 4d39B-1jroA:
undetectable		 4d39B-1jroA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		5 GLY A 417
ILE A 419
GLN A 420
TRP A 587
VAL A 649
 ACT  A 860 ( 3.9A)
None
None
HEM  A 750 (-3.4A)
ACT  A 860 (-4.3A)
 0.25A 4d39B-1lzxA:
59.6		 4d39B-1lzxA:
62.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		5 ILE A 419
GLN A 420
TRP A 587
VAL A 649
SER A 657
 None
None
HEM  A 750 (-3.4A)
ACT  A 860 (-4.3A)
ACT  A 860 ( 3.9A)
 0.69A 4d39B-1lzxA:
59.6		 4d39B-1lzxA:
62.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		6 GLY A 186
ILE A 188
GLN A 189
TRP A 356
VAL A 418
SER A 426
 MPD  A 604 (-3.8A)
None
None
HEM  A 901 (-3.6A)
MPD  A 604 (-4.2A)
MPD  A 604 (-3.1A)
 0.26A 4d39B-1m9qA:
62.4		 4d39B-1m9qA:
95.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		4 GLY L  84
ILE L  88
TRP L  86
VAL L  66
 None
 1.01A 4d39B-1pssL:
0.0		 4d39B-1pssL:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvt SUGAR-PHOSPHATE
ALDOLASE

(Thermotoga
maritima) 		PF00596
(Aldolase_II) 		4 GLY A 174
ILE A 107
TRP A 189
VAL A 187
 None
 1.13A 4d39B-1pvtA:
0.0		 4d39B-1pvtA:
20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		5 GLY A 196
ILE A 198
GLN A 199
TRP A 366
SER A 436
 HEM  A 900 ( 4.1A)
None
None
HEM  A 900 ( 3.5A)
None
 0.34A 4d39B-1qw5A:
57.1		 4d39B-1qw5A:
57.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 GLY A 404
ILE A 405
GLN A 403
TRP A 165
 None
 0.95A 4d39B-1w1kA:
undetectable		 4d39B-1w1kA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		4 GLY A 202
ILE A 200
TRP A 341
VAL A 311
 None
 1.01A 4d39B-1yt8A:
undetectable		 4d39B-1yt8A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY C  69
ILE C  72
GLN C  64
VAL C 128
 None
 1.09A 4d39B-2d3tC:
undetectable		 4d39B-2d3tC:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 GLY A 461
ILE A 462
VAL A 494
SER A 467
 None
 1.11A 4d39B-2eidA:
undetectable		 4d39B-2eidA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekn PROBABLE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN
C

(Pyrococcus
horikoshii) 		PF01967
(MoaC) 		4 GLY A  62
ILE A  60
GLN A  59
VAL A  84
 None
 0.94A 4d39B-2eknA:
undetectable		 4d39B-2eknA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		4 ILE A  78
GLN A  95
VAL A  21
SER A  72
 None
None
OLA  A 130 ( 4.9A)
OLA  A 130 ( 3.8A)
 1.10A 4d39B-2ftbA:
undetectable		 4d39B-2ftbA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2liv LEUCINE

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		4 GLY A  25
ILE A 265
GLN A  28
VAL A 312
 None
 1.01A 4d39B-2livA:
undetectable		 4d39B-2livA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4e O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00963
(Cohesin) 		4 GLY A 153
ILE A 151
VAL A  53
SER A 139
 None
 0.98A 4d39B-2o4eA:
undetectable		 4d39B-2o4eA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odt INOSITOL-TETRAKISPHO
SPHATE 1-KINASE

(Homo sapiens) 		PF05770
(Ins134_P3_kin) 		4 GLY X  51
ILE X  47
GLN X  50
VAL X  39
 None
 1.10A 4d39B-2odtX:
undetectable		 4d39B-2odtX:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owa ARFGAP-LIKE FINGER
DOMAIN CONTAINING
PROTEIN

(Cryptosporidium
parvum) 		PF01412
(ArfGap) 		4 GLY A 125
ILE A 123
GLN A 127
VAL A 107
 None
 1.02A 4d39B-2owaA:
undetectable		 4d39B-2owaA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		4 GLY A 194
TRP A 209
VAL A 207
SER A 124
 None
 0.96A 4d39B-2v9iA:
undetectable		 4d39B-2v9iA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbk TAILSPIKE-PROTEIN

(Shigella virus
Sf6) 		PF12708
(Pectate_lyase_3) 		4 GLY A 302
ILE A 271
GLN A 301
VAL A 363
 None
 1.08A 4d39B-2vbkA:
undetectable		 4d39B-2vbkA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE

(Homo sapiens) 		PF00378
(ECH_1) 		4 GLY A 147
ILE A 146
GLN A 168
VAL A 174
 None
 0.86A 4d39B-2vreA:
undetectable		 4d39B-2vreA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1n O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00041
(fn3)
PF00963
(Cohesin) 		4 GLY A 945
ILE A 947
TRP A 934
VAL A 917
 None
 1.07A 4d39B-2w1nA:
undetectable		 4d39B-2w1nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w38 SIALIDASE

(Pseudomonas
aeruginosa) 		PF13088
(BNR_2) 		4 GLY A 310
ILE A 308
GLN A 300
VAL A 288
 None
 1.14A 4d39B-2w38A:
undetectable		 4d39B-2w38A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		4 GLY A 370
ILE A 368
GLN A 371
SER A 282
 None
 0.90A 4d39B-2w7yA:
undetectable		 4d39B-2w7yA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		4 GLY A 686
ILE A 688
GLN A 684
VAL A 139
 None
 1.09A 4d39B-2y3aA:
undetectable		 4d39B-2y3aA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		4 GLY A  44
ILE A 448
GLN A 446
VAL A  30
 None
 0.92A 4d39B-3a3iA:
undetectable		 4d39B-3a3iA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak1 SUPEROXIDE DISMUTASE
[MN/FE]

(Aeropyrum
pernix) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 GLY A  75
ILE A  77
TRP A 130
VAL A 147
 None
 0.99A 4d39B-3ak1A:
undetectable		 4d39B-3ak1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9t TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Methylobacillus
flagellatus) 		PF03069
(FmdA_AmdA) 		4 GLY A 468
ILE A 459
TRP A 467
VAL A 463
 None
 1.14A 4d39B-3b9tA:
undetectable		 4d39B-3b9tA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 GLY A   8
ILE A   6
VAL A  66
SER A  51
 NAD  A 400 (-3.3A)
None
None
None
 1.06A 4d39B-3cinA:
undetectable		 4d39B-3cinA:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 GLY A 202
ILE A 204
GLN A 205
TRP A 372
SER A 442
 HEM  A 901 ( 3.8A)
None
None
HEM  A 901 ( 3.7A)
None
 0.20A 4d39B-3e7gA:
55.7		 4d39B-3e7gA:
58.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		4 GLY A 163
ILE A 160
GLN A 164
VAL A  88
 None
 0.80A 4d39B-3eqaA:
undetectable		 4d39B-3eqaA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 GLY A 355
ILE A 362
GLN A 354
VAL A 366
 None
 0.96A 4d39B-3fefA:
undetectable		 4d39B-3fefA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gei TRNA MODIFICATION
GTPASE MNME

(Chlorobaculum
tepidum) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		4 GLY A 454
ILE A 452
GLN A 451
VAL A 461
 None
 1.03A 4d39B-3geiA:
undetectable		 4d39B-3geiA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goa 3-KETOACYL-COA
THIOLASE

(Salmonella
enterica) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A  65
ILE A  68
GLN A  60
VAL A 124
 None
 1.04A 4d39B-3goaA:
undetectable		 4d39B-3goaA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1

(Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S) 		4 GLY 1 396
TRP 1 408
VAL 1 407
SER 1 398
 None
None
None
SF4  1 439 ( 4.5A)
 1.06A 4d39B-3i9v1:
undetectable		 4d39B-3i9v1:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv7 ALCOHOL
DEHYDROGENASE IV

(Corynebacterium
glutamicum) 		PF00465
(Fe-ADH) 		4 GLY A 101
ILE A 100
VAL A 146
SER A 124
 None
 1.06A 4d39B-3iv7A:
undetectable		 4d39B-3iv7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krs TRIOSEPHOSPHATE
ISOMERASE

(Cryptosporidium
parvum) 		PF00121
(TIM) 		4 GLY A 230
ILE A 223
VAL A 214
SER A 248
 None
 1.03A 4d39B-3krsA:
undetectable		 4d39B-3krsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 GLY A 309
GLN A 308
TRP A 408
VAL A 502
 CL  A 691 (-3.5A)
None
None
None
 1.10A 4d39B-3pvcA:
undetectable		 4d39B-3pvcA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruc WBGU

(Plesiomonas
shigelloides) 		PF01370
(Epimerase) 		4 GLY A 190
ILE A 189
VAL A 263
SER A 249
 None
 1.07A 4d39B-3rucA:
undetectable		 4d39B-3rucA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 GLY A 564
ILE A 578
TRP A 607
VAL A 600
 None
 0.86A 4d39B-3va6A:
undetectable		 4d39B-3va6A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb9 UNCHARACTERIZED
PROTEIN VPA0735

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		4 GLY A  99
ILE A 235
TRP A  73
VAL A  76
 None
 1.11A 4d39B-3vb9A:
undetectable		 4d39B-3vb9A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vot L-AMINO ACID LIGASE,
BL00235

(Bacillus
licheniformis) 		PF13535
(ATP-grasp_4) 		4 GLY A 388
ILE A 352
GLN A 369
VAL A 367
 None
 1.07A 4d39B-3votA:
undetectable		 4d39B-3votA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		4 GLY A 261
ILE A 296
VAL A 126
SER A 259
 SEP  A 402 ( 2.9A)
PLP  A 401 (-4.6A)
None
PLP  A 401 (-3.4A)
 0.95A 4d39B-3vscA:
undetectable		 4d39B-3vscA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		4 GLY A 320
ILE A 354
GLN A 321
VAL A 109
 None
 0.90A 4d39B-3vsvA:
undetectable		 4d39B-3vsvA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt0 CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		4 GLY A  27
ILE A  28
GLN A 351
SER A 367
 None
 1.14A 4d39B-3wt0A:
undetectable		 4d39B-3wt0A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROBABLE PROTEASOME
SUBUNIT ALPHA TYPE-7

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 GLY G  74
ILE G  66
VAL G  45
SER G 216
 None
 1.08A 4d39B-3wxrG:
undetectable		 4d39B-3wxrG:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 GLY A 182
ILE A 186
VAL A 249
SER A  87
 None
 0.85A 4d39B-4av6A:
undetectable		 4d39B-4av6A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b18 IMPORTIN SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 GLY A 169
ILE A 166
GLN A 167
VAL A 128
 None
 1.00A 4d39B-4b18A:
undetectable		 4d39B-4b18A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj8 ZEBAVIDIN

(Danio rerio) 		PF01382
(Avidin) 		4 GLY A  88
ILE A  84
GLN A  90
SER A   4
 None
 0.91A 4d39B-4bj8A:
undetectable		 4d39B-4bj8A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		4 GLY B 162
ILE B  93
GLN B  96
VAL B 123
 None
 1.07A 4d39B-4ci2B:
undetectable		 4d39B-4ci2B:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Mycoplasma
penetrans) 		PF00145
(DNA_methylase) 		4 GLY A  21
ILE A  20
VAL A 378
SER A 375
 SAH  A 501 (-4.0A)
SAH  A 501 (-4.4A)
None
SAH  A 501 (-3.0A)
 1.07A 4d39B-4dkjA:
undetectable		 4d39B-4dkjA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffk SUPEROXIDE DISMUTASE

(Acidilobus
saccharovorans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 GLY A  87
ILE A  90
TRP A 143
VAL A 160
 None
 0.90A 4d39B-4ffkA:
undetectable		 4d39B-4ffkA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffk SUPEROXIDE DISMUTASE

(Acidilobus
saccharovorans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 GLY A  88
ILE A  90
TRP A 143
VAL A 160
 None
 1.02A 4d39B-4ffkA:
undetectable		 4d39B-4ffkA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0n DNMT2

(Spodoptera
frugiperda) 		PF00145
(DNA_methylase) 		4 GLY A  13
ILE A  12
VAL A 320
SER A 317
 SAH  A 401 ( 4.4A)
SAH  A 401 (-4.3A)
None
SAH  A 401 (-2.6A)
 1.02A 4d39B-4h0nA:
undetectable		 4d39B-4h0nA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igi COLLAGEN ALPHA3(VI)

(Mus musculus) 		PF00092
(VWA) 		4 GLY A1087
ILE A1089
GLN A1085
VAL A1064
 None
 0.94A 4d39B-4igiA:
undetectable		 4d39B-4igiA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		4 GLY A 149
ILE A 147
GLN A 148
VAL A 176
 None
 0.86A 4d39B-4j7bA:
undetectable		 4d39B-4j7bA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kto ISOVALERYL-COA
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 323
ILE A 325
VAL A 307
SER A 252
 None
 1.07A 4d39B-4ktoA:
undetectable		 4d39B-4ktoA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis) 		PF00532
(Peripla_BP_1) 		4 GLY A 144
ILE A 143
GLN A 146
VAL A 259
 None
 1.13A 4d39B-4kzkA:
undetectable		 4d39B-4kzkA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		no annotation 4 GLY B 256
ILE B 306
VAL B 118
SER B 254
 PLP  B 601 (-3.1A)
PLP  B 601 (-4.7A)
None
PLP  B 601 ( 3.9A)
 1.05A 4d39B-4l27B:
undetectable		 4d39B-4l27B:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLY A 421
ILE A 434
VAL A 469
SER A 459
 None
 1.07A 4d39B-4lxfA:
undetectable		 4d39B-4lxfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 GLY A 245
ILE A 243
VAL A   5
SER A 321
 None
 1.01A 4d39B-4m9dA:
undetectable		 4d39B-4m9dA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 GLY A 246
ILE A 243
VAL A   5
SER A 321
 None
 1.08A 4d39B-4m9dA:
undetectable		 4d39B-4m9dA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8u UNCHARACTERIZED
PROTEIN PF2046

(Pyrococcus
furiosus) 		PF13680
(DUF4152) 		4 GLY A  17
ILE A  31
VAL A  34
SER A 160
 None
 1.02A 4d39B-4o8uA:
undetectable		 4d39B-4o8uA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onq DNA
METHYLTRANSFERASE

(Nicotiana
tabacum) 		PF00145
(DNA_methylase) 		4 GLY A 492
ILE A 491
VAL A 464
SER A 461
 SFG  A 700 ( 4.9A)
SFG  A 700 (-4.1A)
None
SFG  A 700 (-2.9A)
 1.01A 4d39B-4onqA:
undetectable		 4d39B-4onqA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE

(Chlamydia
trachomatis) 		PF00595
(PDZ)
PF03572
(Peptidase_S41) 		4 GLY A 474
ILE A 525
GLN A 626
SER A 630
 None
 1.04A 4d39B-4ql6A:
undetectable		 4d39B-4ql6A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8u DNA POLYMERASE IV

(Escherichia
coli) 		PF00817
(IMS)
PF11798
(IMS_HHH)
PF11799
(IMS_C) 		4 GLY B 220
ILE B 222
TRP B 224
VAL B 204
 None
 1.00A 4d39B-4r8uB:
undetectable		 4d39B-4r8uB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 GLY A 141
ILE A 177
GLN A 223
VAL A 246
 None
ACT  A 433 ( 3.8A)
None
None
 1.02A 4d39B-4rs3A:
undetectable		 4d39B-4rs3A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 GLY A 141
ILE A 177
GLN A 223
VAL A 246
 None
 1.08A 4d39B-4rsmA:
undetectable		 4d39B-4rsmA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)

(Agrobacterium
vitis) 		PF01547
(SBP_bac_1) 		5 GLY A  93
ILE A  91
GLN A  95
TRP A  97
VAL A  72
 None
 1.34A 4d39B-4ryaA:
undetectable		 4d39B-4ryaA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II

(Staphylococcus
aureus) 		PF01116
(F_bP_aldolase) 		4 GLY A  21
ILE A  46
GLN A  22
VAL A 207
 None
 1.09A 4d39B-4to8A:
undetectable		 4d39B-4to8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
BETA

(Synanceia
horrida) 		PF00622
(SPRY)
PF13765
(PRY) 		4 GLY B 170
ILE B 168
GLN B 171
VAL B 175
 None
 1.08A 4d39B-4wvmB:
undetectable		 4d39B-4wvmB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Streptobacillus
moniliformis) 		PF13407
(Peripla_BP_4) 		4 GLY A 145
ILE A 142
GLN A 146
VAL A 278
 None
 0.91A 4d39B-4z0nA:
undetectable		 4d39B-4z0nA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomyces
pombe) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		4 GLY I 429
ILE I 439
VAL I 406
SER I 435
 None
 1.12A 4d39B-5b04I:
undetectable		 4d39B-5b04I:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		4 GLY A 481
ILE A 483
GLN A 479
VAL A 159
 None
 1.04A 4d39B-5fsaA:
undetectable		 4d39B-5fsaA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 4 GLY Z 161
ILE Z  92
GLN Z  95
VAL Z 122
 None
 1.03A 4d39B-5hxbZ:
undetectable		 4d39B-5hxbZ:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		PF00106
(adh_short) 		4 GLY A 131
ILE A 128
GLN A 132
VAL A 181
 None
 0.89A 4d39B-5ig2A:
undetectable		 4d39B-5ig2A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilg PHOTORECEPTOR
DEHYDROGENASE,
ISOFORM C

(Drosophila
melanogaster) 		PF00106
(adh_short) 		4 GLY A  12
ILE A  35
VAL A  88
SER A  22
 NAD  A 302 (-3.2A)
None
None
None
 1.13A 4d39B-5ilgA:
undetectable		 4d39B-5ilgA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		4 GLY A 337
ILE A 338
GLN A 326
VAL A 331
 None
 0.96A 4d39B-5inrA:
undetectable		 4d39B-5inrA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioj HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 4 GLY A 156
ILE A 158
VAL A 200
SER A 220
 None
 0.92A 4d39B-5iojA:
undetectable		 4d39B-5iojA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 GLY A 349
ILE A 252
TRP A 339
VAL A 298
 None
 0.97A 4d39B-5jouA:
undetectable		 4d39B-5jouA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy9 PUTATIVE SALICYLATE
SYNTHETASE

(Yersinia
enterocolitica) 		PF00425
(Chorismate_bind) 		4 GLY A 407
ILE A 409
VAL A 179
SER A 412
 ACT  A 503 (-3.8A)
None
None
None
 0.97A 4d39B-5jy9A:
undetectable		 4d39B-5jy9A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		4 GLY A 272
ILE A 270
GLN A 273
VAL A 372
 None
 1.00A 4d39B-5karA:
undetectable		 4d39B-5karA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 GLY A 655
ILE A 657
TRP A 574
VAL A 602
 None
 0.78A 4d39B-5kf7A:
undetectable		 4d39B-5kf7A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1x HMPV F1 SUBUNIT

(Human
metapneumovirus) 		PF00523
(Fusion_gly) 		4 GLY B 393
ILE B 399
VAL B 424
SER B 391
 None
 1.11A 4d39B-5l1xB:
undetectable		 4d39B-5l1xB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)

(Aquifex
aeolicus) 		no annotation 4 GLY B 277
ILE B 279
VAL B 149
SER B  40
 None
 1.07A 4d39B-5l22B:
undetectable		 4d39B-5l22B:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li4 TAIL SHEATH PROTEIN

(Staphylococcus
phage 812) 		no annotation 4 GLY A  40
ILE A  92
GLN A  41
VAL A 344
 None
 0.99A 4d39B-5li4A:
undetectable		 4d39B-5li4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n40 PUTATIVE INVASIN

(Yersinia
pseudotuberculosis) 		PF05689
(DUF823)
PF09134
(Invasin_D3) 		4 GLY A2638
ILE A2637
VAL A2593
SER A2604
 None
 1.08A 4d39B-5n40A:
undetectable		 4d39B-5n40A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L6

(Mycolicibacterium
smegmatis) 		PF00347
(Ribosomal_L6) 		4 GLY G   5
ILE G   4
GLN G   7
VAL G   9
 None
A  A2973 ( 4.5A)
None
None
 0.98A 4d39B-5o60G:
undetectable		 4d39B-5o60G:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT B

(Methanothermococcus
thermolithotrophicus) 		PF02754
(CCG) 		4 GLY B 241
ILE B 243
GLN B 281
VAL B 257
 None
 1.08A 4d39B-5odrB:
undetectable		 4d39B-5odrB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or7 CAPSID PROTEIN
CMRF35-LIKE MOLECULE
1

(Norwalk virus;
Mus musculus) 		no annotation
no annotation 		4 GLY A 333
ILE A 358
GLN A 334
SER C  43
 None
 0.73A 4d39B-5or7A:
undetectable		 4d39B-5or7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sup ATP-DEPENDENT RNA
HELICASE SUB2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLY A  99
ILE A  97
VAL A 102
SER A 119
 None
 0.95A 4d39B-5supA:
undetectable		 4d39B-5supA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suq ATP-DEPENDENT RNA
HELICASE SUB2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLY A  99
ILE A  97
VAL A 102
SER A 119
 None
 0.95A 4d39B-5suqA:
undetectable		 4d39B-5suqA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhp O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		4 GLY A 251
ILE A 264
VAL A 228
SER A 263
 None
 1.06A 4d39B-5uhpA:
undetectable		 4d39B-5uhpA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6

(Saccharomyces
cerevisiae) 		PF10214
(Rrn6) 		4 GLY O 262
ILE O 263
GLN O 270
VAL O 286
 None
 1.06A 4d39B-5w5yO:
undetectable		 4d39B-5w5yO:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0b FRIZZLED-2

(Homo sapiens) 		no annotation 4 GLY B 152
ILE B 113
GLN B 153
SER B 112
 None
 1.01A 4d39B-6c0bB:
undetectable		 4d39B-6c0bB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 5 GLY B 309
ILE B 311
GLN B 362
VAL B 573
SER B 291
 None
 0.97A 4d39B-6f0kB:
undetectable		 4d39B-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 4 GLY A 163
ILE A 160
GLN A 164
VAL A  88
 None
 0.89A 4d39B-6frvA:
undetectable		 4d39B-6frvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Acanthamoeba
castellanii) 		no annotation 4 GLY A  77
ILE A  74
GLN A  78
VAL A  19
 None
 0.84A 4d39B-6fwhA:
undetectable		 4d39B-6fwhA:
undetectable