SIMILAR PATTERNS OF AMINO ACIDS FOR 4D33_B_MTLB870_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eit MU-AGATOXIN-I

(Agelenopsis
aperta) 		PF05980
(Toxin_7) 		4 SER A  23
ARG A  25
GLU A   5
ILE A  31
 None
 1.08A 4d33B-1eitA:
undetectable		 4d33B-1eitA:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR

(Equus caballus) 		PF00079
(Serpin) 		4 ARG A 154
ASN A 158
GLU A 156
ILE A 157
 None
 1.13A 4d33B-1hleA:
0.0		 4d33B-1hleA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1huj INORGANIC
PYROPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF00719
(Pyrophosphatase) 		4 ASN A  66
GLU A  58
ILE A  59
ASP A 117
 None
 1.13A 4d33B-1hujA:
undetectable		 4d33B-1hujA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jov HI1317

(Haemophilus
influenzae) 		PF01263
(Aldose_epim) 		4 ASN A 227
GLU A 189
ILE A 187
ASN A 159
 None
 1.03A 4d33B-1jovA:
undetectable		 4d33B-1jovA:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		5 SER A 477
ARG A 481
ASN A 498
ASN A 569
ASP A 709
 None
 0.45A 4d33B-1lzxA:
58.8		 4d33B-1lzxA:
62.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		4 SER A  67
ASN A 633
GLU A 403
ASP A 425
 None
 1.11A 4d33B-1m1cA:
0.0		 4d33B-1m1cA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN BETA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 SER B 347
ASN B 375
GLU B 359
ASN B 348
 None
 1.15A 4d33B-1m1jB:
0.0		 4d33B-1m1jB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN GAMMA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 ARG C 391
ASN C 189
ILE C 387
ASP C 152
 None
 1.05A 4d33B-1m1jC:
0.0		 4d33B-1m1jC:
20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		7 SER A 246
ARG A 250
ASN A 267
GLU A 269
ILE A 270
ASN A 338
ASP A 478
 None
 0.57A 4d33B-1m9qA:
61.2		 4d33B-1m9qA:
95.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfa HUMAN TRANSCRIPTION
FACTOR NFATC1

(Homo sapiens) 		PF00554
(RHD_DNA_bind) 		4 SER A  23
ASN A 170
GLU A 173
ILE A 172
 None
 1.08A 4d33B-1nfaA:
0.0		 4d33B-1nfaA:
17.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 SER A 256
ARG A 260
GLU A 279
ASN A 348
 None
 0.56A 4d33B-1qw5A:
56.7		 4d33B-1qw5A:
57.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		4 SER A 133
ASN A  75
GLU A  98
ASN A 134
 None
 0.92A 4d33B-1sqjA:
undetectable		 4d33B-1sqjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1za4 THROMBOSPONDIN 1

(Homo sapiens) 		PF02210
(Laminin_G_2) 		4 ARG A 180
ILE A  49
ASN A 189
ASP A  45
 None
 0.89A 4d33B-1za4A:
undetectable		 4d33B-1za4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bii NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 SER A 426
ARG A 144
GLU A 146
ASN A 423
 None
SO4  A 602 (-4.3A)
None
None
 1.10A 4d33B-2biiA:
undetectable		 4d33B-2biiA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7l PHYCOERYTHROCYANIN
ALPHA CHAIN
PHYCOERYTHROCYANIN
BETA CHAIN

(Mastigocladus
laminosus;
Mastigocladus
laminosus) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		4 ASN B  25
GLU B  23
ILE B  24
ASN A  46
 None
 0.94A 4d33B-2c7lB:
undetectable		 4d33B-2c7lB:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cit ENDOGLUCANASE H

(Ruminiclostridium
thermocellum) 		PF02156
(Glyco_hydro_26) 		4 SER A 166
ASN A 128
ILE A 119
ASN A 160
 None
 1.04A 4d33B-2citA:
undetectable		 4d33B-2citA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es3 THROMBOSPONDIN-1

(Homo sapiens) 		PF02210
(Laminin_G_2) 		4 ARG A 180
ILE A  49
ASN A 189
ASP A  45
 None
 1.02A 4d33B-2es3A:
undetectable		 4d33B-2es3A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		4 ASN A 408
ILE A 407
ASN A 398
ASP A 403
 None
 1.09A 4d33B-2f6dA:
undetectable		 4d33B-2f6dA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		4 ASN A 440
GLU A 385
ASN A 376
ASP A 339
 None
 1.10A 4d33B-2gj4A:
undetectable		 4d33B-2gj4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN

(Mus musculus) 		PF00617
(RasGEF) 		4 SER S1124
ARG S1127
GLU S1085
ILE S1086
 None
 0.99A 4d33B-2ijeS:
undetectable		 4d33B-2ijeS:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 ARG A  33
ILE A 204
ASN A  38
ASP A  41
 None
None
ADP  A1001 (-3.9A)
None
 1.03A 4d33B-2iopA:
undetectable		 4d33B-2iopA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kcy 30S RIBOSOMAL
PROTEIN S8E

(Methanothermobacter
thermautotrophicus) 		PF01201
(Ribosomal_S8e) 		4 SER A  75
ARG A  76
ASN A  84
ASP A  80
 None
 1.08A 4d33B-2kcyA:
undetectable		 4d33B-2kcyA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P2

(Homo sapiens) 		PF00428
(Ribosomal_60s) 		5 SER B 117
ASN B 147
ILE B 143
ASN B 115
ASP B 122
 None
 1.49A 4d33B-2lbfB:
undetectable		 4d33B-2lbfB:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obi PHOSPHOLIPID
HYDROPEROXIDE
GLUTATHIONE
PEROXIDASE (GPX4)

(Homo sapiens) 		PF00255
(GSHPx) 		4 ASN A  86
GLU A  88
ILE A  89
ASN A  76
 None
 0.98A 4d33B-2obiA:
undetectable		 4d33B-2obiA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p31 GLUTATHIONE
PEROXIDASE 7

(Homo sapiens) 		PF00255
(GSHPx) 		4 ASN A  97
GLU A  99
ILE A 100
ASN A  87
 None
 1.04A 4d33B-2p31A:
undetectable		 4d33B-2p31A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF00481
(PP2C) 		4 ARG A 187
ASN A 306
GLU A 308
ILE A 309
 None
 0.80A 4d33B-2popA:
undetectable		 4d33B-2popA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 SER A 419
GLU A 314
ILE A 313
ASN A 417
 None
 1.00A 4d33B-2q3zA:
undetectable		 4d33B-2q3zA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rld UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF05635
(23S_rRNA_IVP) 		4 ASN A 107
GLU A 105
ILE A 106
ASP A 102
 None
 1.13A 4d33B-2rldA:
undetectable		 4d33B-2rldA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 ARG C 391
ASN C 189
ILE C 387
ASP C 152
 None
 1.09A 4d33B-3bvhC:
undetectable		 4d33B-3bvhC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 ASN A 440
GLU A 385
ASN A 376
ASP A 339
 None
 1.09A 4d33B-3cemA:
undetectable		 4d33B-3cemA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9i RNA-BINDING PROTEIN
16

(Homo sapiens) 		PF04818
(CTD_bind) 		4 SER A  89
GLU A 126
ILE A 127
ASN A  90
 GOL  A1002 (-3.1A)
None
GOL  A1002 (-4.8A)
SO4  A 147 ( 3.4A)
 1.12A 4d33B-3d9iA:
undetectable		 4d33B-3d9iA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 ARG X 105
ILE X 102
ASN X 273
ASP X  18
 FE  X 326 ( 3.9A)
None
None
None
 1.08A 4d33B-3e13X:
undetectable		 4d33B-3e13X:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 ARG A 266
ASN A 283
GLU A 285
ASN A 354
 AT2  A 906 (-3.6A)
None
None
None
 1.02A 4d33B-3e7gA:
54.4		 4d33B-3e7gA:
58.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas
putida) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 ASN A 419
ILE A 417
ASN A 409
ASP A 408
 None
 1.13A 4d33B-3eqqA:
undetectable		 4d33B-3eqqA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		4 SER A 146
ASN A 150
GLU A 148
ASN A 122
 None
 1.04A 4d33B-3fssA:
undetectable		 4d33B-3fssA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrw HEMOGLOBIN SUBUNIT
BETA-1

(Mus musculus) 		PF00042
(Globin) 		4 SER B  20
ASN B  72
ILE B  68
ASN B  19
 None
 1.15A 4d33B-3hrwB:
undetectable		 4d33B-3hrwB:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in1 UNCHARACTERIZED
SUGAR KINASE YDJH

(Escherichia
coli) 		PF00294
(PfkB) 		4 ASN A  98
ILE A  13
ASN A 144
ASP A  43
 None
 1.15A 4d33B-3in1A:
undetectable		 4d33B-3in1A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq0 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ASN A 418
GLU A 416
ILE A 417
ASP A 412
 None
 1.14A 4d33B-3jq0A:
undetectable		 4d33B-3jq0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khj INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00478
(IMPDH) 		4 ASN A 184
ILE A 185
ASN A  38
ASP A 207
 None
 1.01A 4d33B-3khjA:
undetectable		 4d33B-3khjA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 ASN A 367
GLU A 370
ILE A 369
ASP A 371
 None
 1.03A 4d33B-3l44A:
undetectable		 4d33B-3l44A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9d PUTATIVE GTP
PYROPHOSPHOKINASE

(Streptococcus
mutans) 		PF04607
(RelA_SpoT) 		4 SER A  35
ARG A  25
ILE A  37
ASP A  83
 None
 1.14A 4d33B-3l9dA:
undetectable		 4d33B-3l9dA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9p PERIPLASMIC MUREIN
PEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 ARG A  41
GLU A  36
ILE A  40
ASN A 161
 None
 1.07A 4d33B-3o9pA:
undetectable		 4d33B-3o9pA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omb EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		4 SER A 521
ASN A 482
GLU A 484
ILE A 485
 None
 0.97A 4d33B-3ombA:
undetectable		 4d33B-3ombA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p09 BETA-LACTAMASE

(Francisella
tularensis) 		PF13354
(Beta-lactamase2) 		4 ASN A 162
GLU A 160
ILE A 161
ASN A 128
 None
 1.03A 4d33B-3p09A:
undetectable		 4d33B-3p09A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p14 L-RHAMNOSE ISOMERASE

(Bacillus
halodurans) 		PF06134
(RhaA) 		4 SER A 273
ASN A 270
GLU A 306
ASN A 314
 None
 1.04A 4d33B-3p14A:
undetectable		 4d33B-3p14A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1

(Homo sapiens) 		PF03031
(NIF) 		4 SER A 208
ASN A 187
ASN A 207
ASP A  96
 None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
 1.10A 4d33B-3pglA:
undetectable		 4d33B-3pglA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps0 CRISPR-ASSOCIATED
PROTEIN, CSA2

(Sulfolobus
solfataricus) 		PF01905
(DevR) 		4 ARG A 147
GLU A 300
ILE A 299
ASP A 268
 None
 0.99A 4d33B-3ps0A:
undetectable		 4d33B-3ps0A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 SER A 543
ARG A 570
GLU A 546
ILE A 571
 None
 1.02A 4d33B-3qr1A:
undetectable		 4d33B-3qr1A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s3r CATHEPSIN B-LIKE
PEPTIDASE (C01
FAMILY)

(Schistosoma
mansoni) 		PF00112
(Peptidase_C1) 		4 SER A 315
GLU A 310
ILE A 313
ASN A 226
 None
 1.11A 4d33B-3s3rA:
undetectable		 4d33B-3s3rA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE

(Leptospirillum
rubarum) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 SER A 300
ARG A 262
GLU A 206
ILE A 302
 None
 0.92A 4d33B-3ttgA:
undetectable		 4d33B-3ttgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw5 TRANSGLUTAMINASE
ELICITOR

(Phytophthora
sojae) 		PF16683
(TGase_elicitor) 		4 ASN A 165
GLU A 477
ILE A 478
ASN A 373
 None
 1.08A 4d33B-3tw5A:
undetectable		 4d33B-3tw5A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 SER B2326
ASN B2318
ILE B2321
ASN B1472
 None
 0.80A 4d33B-3zefB:
undetectable		 4d33B-3zefB:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 ASN A 233
GLU A 235
ILE A 236
ASN A 151
 None
 0.85A 4d33B-3zu0A:
undetectable		 4d33B-3zu0A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		4 SER A1740
ARG A1750
GLU A1850
ILE A1851
 None
 1.08A 4d33B-4asiA:
undetectable		 4d33B-4asiA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av2 TYPE IV PILUS
BIOGENESIS AND
COMPETENCE PROTEIN
PILQ

(Neisseria
meningitidis) 		PF03958
(Secretin_N)
PF07660
(STN) 		4 ARG A 402
ASN A 379
GLU A 356
ILE A 357
 None
 1.10A 4d33B-4av2A:
undetectable		 4d33B-4av2A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 ARG A 501
ASN A 510
ILE A 509
ASN A 497
 None
 1.10A 4d33B-4cj0A:
undetectable		 4d33B-4cj0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei8 PLASMID REPLICATION
PROTEIN REPX

(Bacillus cereus) 		PF00091
(Tubulin) 		4 SER A 165
GLU A 372
ILE A 373
ASN A 162
 None
 1.02A 4d33B-4ei8A:
undetectable		 4d33B-4ei8A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 SER A 411
GLU A 475
ILE A 472
ASN A 412
 None
 0.94A 4d33B-4fgvA:
undetectable		 4d33B-4fgvA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 ARG A  29
ASN A 272
ASN A 142
ASP A 145
 None
 1.13A 4d33B-4fn5A:
undetectable		 4d33B-4fn5A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION

(synthetic
construct) 		PF01731
(Arylesterase) 		4 SER A 272
GLU A  53
ASN A 227
ASP A 169
 None
CA  A 402 (-3.4A)
None
CA  A 401 (-2.1A)
 0.93A 4d33B-4hhqA:
undetectable		 4d33B-4hhqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i04 CATHEPSIN B-LIKE
PEPTIDASE (C01
FAMILY)

(Schistosoma
mansoni) 		PF00112
(Peptidase_C1)
PF08127
(Propeptide_C1) 		4 SER A 315
GLU A 310
ILE A 313
ASN A 226
 None
 1.12A 4d33B-4i04A:
undetectable		 4d33B-4i04A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i05 CATHEPSIN B-LIKE
PEPTIDASE (C01
FAMILY)

(Schistosoma
mansoni) 		PF00112
(Peptidase_C1) 		4 SER A 315
GLU A 310
ILE A 313
ASN A 226
 None
 1.01A 4d33B-4i05A:
undetectable		 4d33B-4i05A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idi ORYZA SATIVA
RURM1-RELATED

(Plasmodium
yoelii) 		PF09138
(Urm1) 		4 SER A  55
ARG A  44
GLU A  37
ILE A  40
 None
 1.07A 4d33B-4idiA:
undetectable		 4d33B-4idiA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 SER A 125
ARG A 130
GLU A  14
ASP A 224
 None
 1.11A 4d33B-4kcdA:
undetectable		 4d33B-4kcdA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9m RAS GUANYL-RELEASING
PROTEIN 1

(Homo sapiens) 		PF00130
(C1_1)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF13405
(EF-hand_6) 		4 SER A 456
ASN A 252
GLU A 245
ILE A 248
 None
 0.90A 4d33B-4l9mA:
undetectable		 4d33B-4l9mA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ASN A 867
ILE A 868
ASN A 933
ASP A 937
 None
 1.09A 4d33B-4ldeA:
undetectable		 4d33B-4ldeA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ASN A 324
GLU A 322
ILE A 323
ASN A 392
 None
 0.65A 4d33B-4na3A:
undetectable		 4d33B-4na3A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5t LIPOPROTEIN

(Streptococcus
mutans) 		PF03180
(Lipoprotein_9) 		4 ASN A 235
GLU A 108
ILE A 236
ASN A  90
 None
 0.99A 4d33B-4q5tA:
undetectable		 4d33B-4q5tA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlz SJCHGC07024 PROTEIN

(Schistosoma
japonicum) 		PF00719
(Pyrophosphatase) 		4 ASN A  64
GLU A  56
ILE A  57
ASP A 115
 None
CO  A 403 (-3.4A)
None
CO  A 403 ( 3.5A)
 0.96A 4d33B-4qlzA:
undetectable		 4d33B-4qlzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru3 PUNCTURING PROTEIN
GP41

(Pseudomonas
virus SN) 		no annotation 4 SER A 160
ARG A 162
ASN A 165
ILE A 166
 None
 0.89A 4d33B-4ru3A:
undetectable		 4d33B-4ru3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL

(Plasmodium
berghei) 		no annotation 4 ASN A 119
GLU A 117
ILE A 116
ASP A  55
 None
 0.94A 4d33B-4u5aA:
undetectable		 4d33B-4u5aA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u66 PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Alkaliphilus
oremlandii) 		PF01625
(PMSR) 		4 ASN A 116
GLU A 113
ILE A 112
ASN A  80
 None
 1.12A 4d33B-4u66A:
undetectable		 4d33B-4u66A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uei STEROL CARRIER
PROTEIN
2/3-OXOACYL-COA
THIOLASE

(Helicoverpa
armigera) 		PF02036
(SCP2) 		4 ARG A  48
GLU A  37
ILE A  44
ASN A  69
 None
 0.92A 4d33B-4ueiA:
undetectable		 4d33B-4ueiA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y25 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
EXPORT PROTEIN

(Escherichia
coli) 		no annotation 4 SER A 586
ASN A 588
ILE A 589
ASN A 554
 None
 0.97A 4d33B-4y25A:
undetectable		 4d33B-4y25A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Homo sapiens) 		PF01966
(HD) 		4 SER A 214
ARG A 164
GLU A 234
ASP A 218
 None
DGT  A 701 (-3.3A)
None
None
 1.06A 4d33B-4zweA:
undetectable		 4d33B-4zweA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 SER A  98
ASN A 237
GLU A 245
ASN A  99
 None
 1.09A 4d33B-5amqA:
undetectable		 4d33B-5amqA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Homo sapiens) 		PF01966
(HD) 		4 SER A 214
ARG A 164
GLU A 234
ASP A 218
 None
DG3  A2001 (-3.0A)
DG3  A2001 ( 4.3A)
None
 1.01A 4d33B-5ao0A:
undetectable		 4d33B-5ao0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuv ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
cruzi) 		PF00719
(Pyrophosphatase) 		4 ASN A 247
GLU A 239
ILE A 240
ASP A 293
 None
 0.92A 4d33B-5cuvA:
undetectable		 4d33B-5cuvA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
brucei) 		PF00719
(Pyrophosphatase) 		4 ASN A 247
GLU A 239
ILE A 240
ASP A 293
 None
 1.10A 4d33B-5cuyA:
undetectable		 4d33B-5cuyA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2v GTP
PYROPHOSPHOKINASE
YJBM

(Bacillus
subtilis) 		no annotation 4 SER V  38
ARG V  28
ILE V  40
ASP V  85
 None
 1.12A 4d33B-5f2vV:
undetectable		 4d33B-5f2vV:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Escherichia
coli;
Danio rerio) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 SER A 353
ARG A 355
ILE A 349
ASP A 208
 None
 1.11A 4d33B-5gpqA:
undetectable		 4d33B-5gpqA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 SER A 589
ASN A 421
GLU A 419
ILE A 418
 None
 0.97A 4d33B-5gtmA:
undetectable		 4d33B-5gtmA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE

(Trypanosoma
cruzi) 		PF00262
(Calreticulin) 		4 ASN A 296
GLU A 205
ILE A 206
ASP A 208
 None
 1.12A 4d33B-5hcfA:
undetectable		 4d33B-5hcfA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		4 SER A 407
ARG A 409
ILE A 403
ASP A 262
 None
 1.04A 4d33B-5hzwA:
undetectable		 4d33B-5hzwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irc RHO
GTPASE-ACTIVATING
PROTEIN 35

(Rattus
norvegicus) 		PF00620
(RhoGAP) 		4 SER A1383
GLU A1426
ILE A1429
ASN A1386
 None
 1.10A 4d33B-5ircA:
undetectable		 4d33B-5ircA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw9 BASEPLATE WEDGE
PROTEIN GP25

(Escherichia
virus T4) 		PF04965
(GPW_gp25) 		4 SER A  79
ASN A  76
GLU A  74
ILE A  77
 None
 1.05A 4d33B-5iw9A:
undetectable		 4d33B-5iw9A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 SER A1147
ARG A1153
GLU A1349
ILE A1157
 None
 1.13A 4d33B-5iy9A:
undetectable		 4d33B-5iy9A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 SER A 170
GLU A 128
ILE A 127
ASP A 125
 None
 1.12A 4d33B-5j0aA:
undetectable		 4d33B-5j0aA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyg ACTIN-LIKE ATPASE

(Magnetospirillum
magneticum) 		PF06723
(MreB_Mbl) 		4 ARG A 305
GLU A 263
ILE A 262
ASP A 260
 None
 1.12A 4d33B-5jygA:
undetectable		 4d33B-5jygA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE

(Plasmodium
falciparum) 		PF00027
(cNMP_binding) 		4 ARG A 181
GLU A 176
ILE A 180
ASN A 203
 None
 1.04A 4d33B-5kbfA:
undetectable		 4d33B-5kbfA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 4 SER A  22
GLU A 145
ILE A 141
ASP A 266
 None
 1.14A 4d33B-5muxA:
undetectable		 4d33B-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nf4 MINOR FIMBRIUM TIP
SUBUNIT MFA3

(Porphyromonas
gingivalis) 		no annotation 4 ASN A 222
GLU A 225
ILE A 252
ASN A 271
 None
 1.05A 4d33B-5nf4A:
undetectable		 4d33B-5nf4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzz TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 4 ARG A 187
ASN A 306
GLU A 308
ILE A 309
 None
 0.81A 4d33B-5nzzA:
undetectable		 4d33B-5nzzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3u PTS SYSTEM, IIA
COMPONENT

(Streptococcus
pneumoniae) 		PF03610
(EIIA-man) 		4 SER A 111
ARG A   7
GLU A 120
ILE A 121
 None
 1.02A 4d33B-5t3uA:
undetectable		 4d33B-5t3uA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		4 ASN A 125
ILE A 223
ASN A 185
ASP A 188
 None
 1.11A 4d33B-5xsyA:
undetectable		 4d33B-5xsyA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 SER A2168
ARG A2169
GLU A2495
ILE A2165
 None
 1.14A 4d33B-6b3rA:
undetectable		 4d33B-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elw PHOSPHOLIPID
HYDROPEROXIDE
GLUTATHIONE
PEROXIDASE,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 ASN A  86
GLU A  88
ILE A  89
ASN A  76
 None
 0.98A 4d33B-6elwA:
undetectable		 4d33B-6elwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd 26S PROTEASOME
SUBUNIT S5A

(Rattus
norvegicus) 		no annotation 4 ASN W  12
GLU W 118
ILE W  84
ASP W 119
 None
 1.01A 4d33B-6epdW:
undetectable		 4d33B-6epdW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 4 SER D 309
ILE D 305
ASN D 312
ASP D 348
 None
 1.01A 4d33B-6fmlD:
undetectable		 4d33B-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g4q SUCCINATE--COA
LIGASE [ADP-FORMING]
SUBUNIT BETA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 ASN B 258
GLU B 193
ILE B 192
ASP B 194
 None
 1.13A 4d33B-6g4qB:
undetectable		 4d33B-6g4qB:
undetectable