SIMILAR PATTERNS OF AMINO ACIDS FOR 4D33_B_ACTB860

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 GLY A 546
ILE A 544
VAL A 578
SER A 574
 None
 1.13A 4d33B-1hwwA:
0.0		 4d33B-1hwwA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		4 GLY A  68
ILE A  34
VAL A 473
SER A  71
 None
 1.26A 4d33B-1hxjA:
0.0		 4d33B-1hxjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		4 GLY A 114
ILE A 116
VAL A 111
SER A 186
 None
 1.24A 4d33B-1itxA:
0.0		 4d33B-1itxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jro XANTHINE
DEHYDROGENASE, CHAIN
A

(Rhodobacter
capsulatus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		4 GLY A 205
ILE A 202
TRP A 211
VAL A 212
 FAD  A3005 (-3.3A)
None
None
None
 1.12A 4d33B-1jroA:
0.0		 4d33B-1jroA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		4 GLY A 417
ILE A 419
TRP A 587
VAL A 649
 ACT  A 860 ( 3.9A)
None
HEM  A 750 (-3.4A)
ACT  A 860 (-4.3A)
 0.28A 4d33B-1lzxA:
58.8		 4d33B-1lzxA:
62.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		4 ILE A 419
TRP A 587
VAL A 649
SER A 657
 None
HEM  A 750 (-3.4A)
ACT  A 860 (-4.3A)
ACT  A 860 ( 3.9A)
 0.81A 4d33B-1lzxA:
58.8		 4d33B-1lzxA:
62.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 GLY A 186
ILE A 188
TRP A 356
VAL A 418
SER A 426
 MPD  A 604 (-3.8A)
None
HEM  A 901 (-3.6A)
MPD  A 604 (-4.2A)
MPD  A 604 (-3.1A)
 0.27A 4d33B-1m9qA:
61.2		 4d33B-1m9qA:
95.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		4 GLY A 294
ILE A 296
TRP A 756
VAL A 289
 None
 1.23A 4d33B-1mhsA:
undetectable		 4d33B-1mhsA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		4 GLY L  84
ILE L  88
TRP L  86
VAL L  66
 None
 1.03A 4d33B-1pssL:
0.0		 4d33B-1pssL:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvt SUGAR-PHOSPHATE
ALDOLASE

(Thermotoga
maritima) 		PF00596
(Aldolase_II) 		4 GLY A 174
ILE A 107
TRP A 189
VAL A 163
 None
 1.16A 4d33B-1pvtA:
undetectable		 4d33B-1pvtA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvt SUGAR-PHOSPHATE
ALDOLASE

(Thermotoga
maritima) 		PF00596
(Aldolase_II) 		4 GLY A 174
ILE A 107
TRP A 189
VAL A 187
 None
 1.13A 4d33B-1pvtA:
undetectable		 4d33B-1pvtA:
20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 GLY A 196
ILE A 198
TRP A 366
SER A 436
 HEM  A 900 ( 4.1A)
None
HEM  A 900 ( 3.5A)
None
 0.32A 4d33B-1qw5A:
56.7		 4d33B-1qw5A:
57.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		4 GLY A 242
ILE A 206
TRP A 145
VAL A 141
 None
 1.21A 4d33B-1uznA:
undetectable		 4d33B-1uznA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		4 GLY A 202
ILE A 200
TRP A 341
VAL A 311
 None
 1.00A 4d33B-1yt8A:
undetectable		 4d33B-1yt8A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE

(Escherichia
coli) 		PF00480
(ROK) 		4 GLY A 182
ILE A 183
VAL A 133
SER A 217
 None
 1.24A 4d33B-2aa4A:
undetectable		 4d33B-2aa4A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3b GLUCOSE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF01547
(SBP_bac_1) 		4 GLY A  68
ILE A 105
VAL A  65
SER A 113
 None
 1.25A 4d33B-2b3bA:
undetectable		 4d33B-2b3bA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c45 ASPARTATE
1-DECARBOXYLASE
PRECURSOR

(Mycobacterium
tuberculosis) 		PF02261
(Asp_decarbox) 		4 GLY A  41
ILE A  60
VAL A  44
SER A  25
 None
 1.18A 4d33B-2c45A:
undetectable		 4d33B-2c45A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 GLY A 461
ILE A 462
VAL A 494
SER A 467
 None
 1.14A 4d33B-2eidA:
undetectable		 4d33B-2eidA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hp3 IDS-EPIMERASE

(Agrobacterium
tumefaciens) 		PF03972
(MmgE_PrpD) 		4 GLY A 180
ILE A 181
VAL A 157
SER A 212
 None
 1.24A 4d33B-2hp3A:
undetectable		 4d33B-2hp3A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE

(Caenorhabditis
elegans) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 GLY A 146
ILE A 148
VAL A 131
SER A 118
 None
 1.16A 4d33B-2o3jA:
undetectable		 4d33B-2o3jA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4e O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00963
(Cohesin) 		4 GLY A 153
ILE A 151
VAL A  53
SER A 139
 None
 0.99A 4d33B-2o4eA:
undetectable		 4d33B-2o4eA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		4 GLY A 194
TRP A 209
VAL A 207
SER A 124
 None
 0.96A 4d33B-2v9iA:
undetectable		 4d33B-2v9iA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1n O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00041
(fn3)
PF00963
(Cohesin) 		4 GLY A 945
ILE A 947
TRP A 934
VAL A 917
 None
 1.10A 4d33B-2w1nA:
undetectable		 4d33B-2w1nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynp COATOMER SUBUNIT
BETA'

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		4 GLY A 226
ILE A 210
VAL A 262
SER A 245
 None
 1.24A 4d33B-2ynpA:
undetectable		 4d33B-2ynpA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak1 SUPEROXIDE DISMUTASE
[MN/FE]

(Aeropyrum
pernix) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 GLY A  75
ILE A  77
TRP A 130
VAL A 147
 None
 0.99A 4d33B-3ak1A:
undetectable		 4d33B-3ak1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9t TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Methylobacillus
flagellatus) 		PF03069
(FmdA_AmdA) 		4 GLY A 468
ILE A 459
TRP A 467
VAL A 463
 None
 1.14A 4d33B-3b9tA:
undetectable		 4d33B-3b9tA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Enterococcus
faecalis) 		PF13377
(Peripla_BP_3) 		4 GLY A 287
ILE A  81
TRP A 286
VAL A 149
 None
 1.15A 4d33B-3cs3A:
undetectable		 4d33B-3cs3A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 GLY A 817
ILE A 808
TRP A 843
VAL A 844
 None
 1.27A 4d33B-3decA:
undetectable		 4d33B-3decA:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 GLY A 202
ILE A 204
TRP A 372
SER A 442
 HEM  A 901 ( 3.8A)
None
HEM  A 901 ( 3.7A)
None
 0.22A 4d33B-3e7gA:
54.4		 4d33B-3e7gA:
58.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		4 GLY A 275
ILE A 250
VAL A 292
SER A 254
 None
 1.23A 4d33B-3eafA:
undetectable		 4d33B-3eafA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC3

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF03870
(RNA_pol_Rpb8) 		4 GLY H  99
ILE A 619
VAL A 570
SER H  96
 None
 1.24A 4d33B-3h0gH:
undetectable		 4d33B-3h0gH:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbu SECRETED PROTEASE C

(Dickeya
chrysanthemi) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 GLY P 320
ILE P 248
VAL P 338
SER P 294
 None
 1.20A 4d33B-3hbuP:
undetectable		 4d33B-3hbuP:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1

(Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S) 		4 GLY 1 396
TRP 1 408
VAL 1 407
SER 1 398
 None
None
None
SF4  1 439 ( 4.5A)
 1.07A 4d33B-3i9v1:
undetectable		 4d33B-3i9v1:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv7 ALCOHOL
DEHYDROGENASE IV

(Corynebacterium
glutamicum) 		PF00465
(Fe-ADH) 		4 GLY A 101
ILE A 100
VAL A 146
SER A 124
 None
 1.05A 4d33B-3iv7A:
undetectable		 4d33B-3iv7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN

(Neisseria
gonorrhoeae) 		PF05076
(SUFU) 		4 GLY A  57
ILE A  58
VAL A   7
SER A  55
 None
 1.21A 4d33B-3k5jA:
undetectable		 4d33B-3k5jA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		4 GLY A 114
ILE A 139
VAL A 194
SER A 132
 None
 1.19A 4d33B-3k9dA:
undetectable		 4d33B-3k9dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE

(Mus musculus) 		PF00266
(Aminotran_5) 		4 GLY A 128
ILE A 129
VAL A 176
SER A 181
 None
 1.19A 4d33B-3kgwA:
undetectable		 4d33B-3kgwA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF04816
(TrmK) 		4 GLY A  16
ILE A  18
VAL A  13
SER A  86
 None
 1.26A 4d33B-3kr9A:
undetectable		 4d33B-3kr9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krs TRIOSEPHOSPHATE
ISOMERASE

(Cryptosporidium
parvum) 		PF00121
(TIM) 		4 GLY A 230
ILE A 223
VAL A 214
SER A 248
 None
 1.07A 4d33B-3krsA:
undetectable		 4d33B-3krsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lx6 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		4 GLY A  97
ILE A  96
VAL A 440
SER A 437
 None
 1.20A 4d33B-3lx6A:
undetectable		 4d33B-3lx6A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 GLY A 425
ILE A  23
TRP A 427
SER A   2
 None
 1.14A 4d33B-3mduA:
undetectable		 4d33B-3mduA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		4 GLY A  97
ILE A  96
VAL A 440
SER A 437
 None
 1.19A 4d33B-3me5A:
undetectable		 4d33B-3me5A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nym UNCHARACTERIZED
PROTEIN

(Neisseria
meningitidis) 		no annotation 4 GLY A  15
ILE A  12
TRP A  40
VAL A  27
 None
MLY  A   8 ( 3.9A)
MLY  A  39 ( 4.1A)
None
 1.26A 4d33B-3nymA:
undetectable		 4d33B-3nymA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1u SUSD HOMOLOG

(Parabacteroides
distasonis) 		PF12741
(SusD-like) 		4 GLY A  51
ILE A  55
TRP A 132
VAL A 136
 None
 1.21A 4d33B-3p1uA:
undetectable		 4d33B-3p1uA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN

(Legionella
pneumophila) 		PF13407
(Peripla_BP_4) 		4 GLY A 160
ILE A 162
VAL A  66
SER A  90
 None
 1.27A 4d33B-3rotA:
undetectable		 4d33B-3rotA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruc WBGU

(Plesiomonas
shigelloides) 		PF01370
(Epimerase) 		4 GLY A 190
ILE A 189
VAL A 263
SER A 249
 None
 1.08A 4d33B-3rucA:
undetectable		 4d33B-3rucA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		4 GLY A 205
ILE A 208
TRP A 185
VAL A 143
 None
 1.23A 4d33B-3tqoA:
undetectable		 4d33B-3tqoA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 GLY A 564
ILE A 578
TRP A 607
VAL A 600
 None
 0.88A 4d33B-3va6A:
undetectable		 4d33B-3va6A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb9 UNCHARACTERIZED
PROTEIN VPA0735

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		4 GLY A  99
ILE A 235
TRP A  73
VAL A  76
 None
 1.12A 4d33B-3vb9A:
undetectable		 4d33B-3vb9A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vom PUTATIVE
PHOSPHOSERINE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		4 GLY A  80
ILE A  78
VAL A  58
SER A 244
 None
 1.13A 4d33B-3vomA:
undetectable		 4d33B-3vomA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		4 GLY A 261
ILE A 296
VAL A 126
SER A 259
 SEP  A 402 ( 2.9A)
PLP  A 401 (-4.6A)
None
PLP  A 401 (-3.4A)
 0.99A 4d33B-3vscA:
undetectable		 4d33B-3vscA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROBABLE PROTEASOME
SUBUNIT ALPHA TYPE-7

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 GLY G  74
ILE G  66
VAL G  45
SER G 216
 None
 1.05A 4d33B-3wxrG:
undetectable		 4d33B-3wxrG:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 GLY A 182
ILE A 186
VAL A 249
SER A  87
 None
 0.84A 4d33B-4av6A:
undetectable		 4d33B-4av6A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Mycoplasma
penetrans) 		PF00145
(DNA_methylase) 		4 GLY A  21
ILE A  20
VAL A 378
SER A 375
 SAH  A 501 (-4.0A)
SAH  A 501 (-4.4A)
None
SAH  A 501 (-3.0A)
 1.08A 4d33B-4dkjA:
undetectable		 4d33B-4dkjA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffk SUPEROXIDE DISMUTASE

(Acidilobus
saccharovorans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 GLY A  87
ILE A  90
TRP A 143
VAL A 160
 None
 0.90A 4d33B-4ffkA:
undetectable		 4d33B-4ffkA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffk SUPEROXIDE DISMUTASE

(Acidilobus
saccharovorans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 GLY A  88
ILE A  90
TRP A 143
VAL A 160
 None
 1.01A 4d33B-4ffkA:
undetectable		 4d33B-4ffkA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0n DNMT2

(Spodoptera
frugiperda) 		PF00145
(DNA_methylase) 		4 GLY A  13
ILE A  12
VAL A 320
SER A 317
 SAH  A 401 ( 4.4A)
SAH  A 401 (-4.3A)
None
SAH  A 401 (-2.6A)
 1.03A 4d33B-4h0nA:
undetectable		 4d33B-4h0nA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION

(synthetic
construct) 		PF01731
(Arylesterase) 		4 GLY A 116
ILE A 117
VAL A 333
SER A  66
 CA  A 401 ( 4.6A)
None
None
None
 1.23A 4d33B-4hhqA:
undetectable		 4d33B-4hhqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kto ISOVALERYL-COA
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 323
ILE A 325
VAL A 307
SER A 252
 None
 1.09A 4d33B-4ktoA:
undetectable		 4d33B-4ktoA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		no annotation 4 GLY B 256
ILE B 306
VAL B 118
SER B 254
 PLP  B 601 (-3.1A)
PLP  B 601 (-4.7A)
None
PLP  B 601 ( 3.9A)
 1.09A 4d33B-4l27B:
undetectable		 4d33B-4l27B:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLY A 421
ILE A 434
VAL A 469
SER A 459
 None
 1.05A 4d33B-4lxfA:
undetectable		 4d33B-4lxfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 GLY A 245
ILE A 243
VAL A   5
SER A 321
 None
 1.02A 4d33B-4m9dA:
undetectable		 4d33B-4m9dA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8u UNCHARACTERIZED
PROTEIN PF2046

(Pyrococcus
furiosus) 		PF13680
(DUF4152) 		4 GLY A  17
ILE A  31
VAL A  34
SER A 160
 None
 1.00A 4d33B-4o8uA:
undetectable		 4d33B-4o8uA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc9 PUTATIVE
O-ACETYLHOMOSERINE
(THIOL)-LYASE

(Campylobacter
jejuni) 		PF01053
(Cys_Met_Meta_PP) 		4 GLY A  77
ILE A  78
VAL A 198
SER A 258
 None
 1.15A 4d33B-4oc9A:
undetectable		 4d33B-4oc9A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onq DNA
METHYLTRANSFERASE

(Nicotiana
tabacum) 		PF00145
(DNA_methylase) 		4 GLY A 492
ILE A 491
VAL A 464
SER A 461
 SFG  A 700 ( 4.9A)
SFG  A 700 (-4.1A)
None
SFG  A 700 (-2.9A)
 1.02A 4d33B-4onqA:
undetectable		 4d33B-4onqA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1p L-ARABINOSE
ISOMERASE

(Geobacillus
kaustophilus) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		4 GLY A 444
ILE A 404
VAL A 191
SER A 393
 None
 1.23A 4d33B-4r1pA:
undetectable		 4d33B-4r1pA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8u DNA POLYMERASE IV

(Escherichia
coli) 		PF00817
(IMS)
PF11798
(IMS_HHH)
PF11799
(IMS_C) 		4 GLY B 220
ILE B 222
TRP B 224
VAL B 204
 None
 1.02A 4d33B-4r8uB:
undetectable		 4d33B-4r8uB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY

(Trichormus
variabilis) 		PF13458
(Peripla_BP_6) 		4 GLY A 158
ILE A 159
VAL A 173
SER A 132
 None
None
None
PRO  A 501 (-2.6A)
 1.23A 4d33B-4rdcA:
undetectable		 4d33B-4rdcA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus) 		PF01266
(DAO) 		4 GLY A 216
ILE A 206
VAL A 225
SER A 208
 None
None
None
FAD  A 401 (-4.4A)
 1.17A 4d33B-4yshA:
undetectable		 4d33B-4yshA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzf BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF00955
(HCO3_cotransp) 		4 GLY A 802
ILE A 803
VAL A 732
SER A 525
 None
 1.24A 4d33B-4yzfA:
undetectable		 4d33B-4yzfA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afu DYNACTIN

(Sus scrofa) 		PF00022
(Actin) 		4 GLY A 343
ILE A 346
TRP A 341
VAL A  13
 None
 1.21A 4d33B-5afuA:
undetectable		 4d33B-5afuA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomyces
pombe) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		4 GLY I 429
ILE I 439
VAL I 406
SER I 435
 None
 1.10A 4d33B-5b04I:
undetectable		 4d33B-5b04I:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE
PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides;
Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ)
PF03170
(BcsB) 		4 GLY A  43
ILE A  45
VAL B 585
SER A  48
 None
 1.23A 4d33B-5ej1A:
undetectable		 4d33B-5ej1A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A  65
ILE A 710
VAL A  60
SER A 311
 None
EDO  A1870 (-4.1A)
None
EDO  A1870 (-4.9A)
 1.26A 4d33B-5fjiA:
undetectable		 4d33B-5fjiA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmf DNA REPAIR HELICASE
RAD25, SSL2

(Saccharomyces
cerevisiae) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		4 GLY 1 396
ILE 1 397
VAL 1 409
SER 1 450
 None
 1.14A 4d33B-5fmf1:
undetectable		 4d33B-5fmf1:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwn PROTEIN RCC2

(Homo sapiens) 		PF00415
(RCC1) 		4 GLY A 183
ILE A 196
VAL A 190
SER A 173
 None
 1.24A 4d33B-5gwnA:
undetectable		 4d33B-5gwnA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilg PHOTORECEPTOR
DEHYDROGENASE,
ISOFORM C

(Drosophila
melanogaster) 		PF00106
(adh_short) 		4 GLY A  12
ILE A  35
VAL A  88
SER A  22
 NAD  A 302 (-3.2A)
None
None
None
 1.14A 4d33B-5ilgA:
undetectable		 4d33B-5ilgA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioj HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 4 GLY A 156
ILE A 158
VAL A 200
SER A 220
 None
 0.90A 4d33B-5iojA:
undetectable		 4d33B-5iojA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmu PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE

([Eubacterium]
rectale) 		PF01522
(Polysacc_deac_1) 		4 GLY A 401
ILE A 402
VAL A 494
SER A 395
 OCS  A 399 ( 4.2A)
OCS  A 399 ( 3.6A)
None
None
 1.19A 4d33B-5jmuA:
undetectable		 4d33B-5jmuA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 GLY A 349
ILE A 252
TRP A 339
VAL A 298
 None
 0.97A 4d33B-5jouA:
undetectable		 4d33B-5jouA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A 129
ILE A 127
VAL A 312
SER A  92
 None
 1.24A 4d33B-5jp0A:
undetectable		 4d33B-5jp0A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy9 PUTATIVE SALICYLATE
SYNTHETASE

(Yersinia
enterocolitica) 		PF00425
(Chorismate_bind) 		4 GLY A 407
ILE A 409
VAL A 179
SER A 412
 ACT  A 503 (-3.8A)
None
None
None
 0.94A 4d33B-5jy9A:
undetectable		 4d33B-5jy9A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 GLY A 655
ILE A 657
TRP A 574
VAL A 602
 None
 0.79A 4d33B-5kf7A:
undetectable		 4d33B-5kf7A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1x HMPV F1 SUBUNIT

(Human
metapneumovirus) 		PF00523
(Fusion_gly) 		4 GLY B 393
ILE B 399
VAL B 424
SER B 391
 None
 1.13A 4d33B-5l1xB:
undetectable		 4d33B-5l1xB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 4 GLY A 127
ILE A 125
VAL A 308
SER A  87
 None
 1.25A 4d33B-5m6gA:
undetectable		 4d33B-5m6gA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n40 PUTATIVE INVASIN

(Yersinia
pseudotuberculosis) 		PF05689
(DUF823)
PF09134
(Invasin_D3) 		4 GLY A2638
ILE A2637
VAL A2593
SER A2604
 None
 1.05A 4d33B-5n40A:
undetectable		 4d33B-5n40A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 4 GLY A  61
ILE A 705
VAL A  56
SER A 306
 None
 1.26A 4d33B-5nbsA:
undetectable		 4d33B-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ode GLL2934 PROTEIN

(Gloeobacter
violaceus) 		no annotation 4 GLY A  24
ILE A  71
VAL A 294
SER A  51
 FAD  A 400 (-2.9A)
None
FAD  A 400 (-3.2A)
FAD  A 400 (-3.2A)
 1.16A 4d33B-5odeA:
undetectable		 4d33B-5odeA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Mycolicibacterium
smegmatis) 		no annotation 4 GLY A 250
ILE A 214
TRP A 153
VAL A 149
 None
 1.25A 4d33B-5ovkA:
undetectable		 4d33B-5ovkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sup ATP-DEPENDENT RNA
HELICASE SUB2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLY A  99
ILE A  97
VAL A 102
SER A 119
 None
 0.97A 4d33B-5supA:
undetectable		 4d33B-5supA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suq ATP-DEPENDENT RNA
HELICASE SUB2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLY A  99
ILE A  97
VAL A 102
SER A 119
 None
 0.97A 4d33B-5suqA:
undetectable		 4d33B-5suqA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		4 GLY A 251
ILE A 264
VAL A 228
SER A 263
 None
 1.25A 4d33B-5uhkA:
undetectable		 4d33B-5uhkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhp O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		4 GLY A 251
ILE A 264
VAL A 228
SER A 263
 None
 1.05A 4d33B-5uhpA:
undetectable		 4d33B-5uhpA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvo PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		4 GLY A 251
ILE A 264
VAL A 228
SER A 263
 None
 1.27A 4d33B-5vvoA:
undetectable		 4d33B-5vvoA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb0 FUSION GLYCOPROTEIN
F0

(Human
metapneumovirus) 		no annotation 4 GLY F 393
ILE F 399
VAL F 424
SER F 391
 None
 1.26A 4d33B-5wb0F:
undetectable		 4d33B-5wb0F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ws4 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Acinetobacter
baumannii) 		no annotation 4 GLY A 598
ILE A 293
VAL A 603
SER A 637
 None
 1.24A 4d33B-5ws4A:
undetectable		 4d33B-5ws4A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 4 GLY A 164
ILE A 168
VAL A 156
SER A 124
 None
 1.25A 4d33B-5xjhA:
undetectable		 4d33B-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ane POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 4 GLY A 137
ILE A 141
VAL A 129
SER A  97
 None
 1.25A 4d33B-6aneA:
undetectable		 4d33B-6aneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 4 GLY B 309
ILE B 311
VAL B 573
SER B 291
 None
 0.88A 4d33B-6f0kB:
undetectable		 4d33B-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gu8 -

(-) 		no annotation 4 GLY A 353
ILE A 288
VAL A 340
SER A 326
 None
 1.19A 4d33B-6gu8A:
undetectable		 4d33B-6gu8A:
undetectable