SIMILAR PATTERNS OF AMINO ACIDS FOR 4D33_A_MTLA870

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eit MU-AGATOXIN-I

(Agelenopsis
aperta) 		PF05980
(Toxin_7) 		4 SER A  23
ARG A  25
GLU A   5
ILE A  31
 None
 1.06A 4d33A-1eitA:
undetectable		 4d33A-1eitA:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR

(Equus caballus) 		PF00079
(Serpin) 		4 ARG A 154
ASN A 158
GLU A 156
ILE A 157
 None
 1.10A 4d33A-1hleA:
0.0		 4d33A-1hleA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1huj INORGANIC
PYROPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF00719
(Pyrophosphatase) 		4 ASN A  66
GLU A  58
ILE A  59
ASP A 117
 None
 1.11A 4d33A-1hujA:
0.0		 4d33A-1hujA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jov HI1317

(Haemophilus
influenzae) 		PF01263
(Aldose_epim) 		4 ASN A 227
GLU A 189
ILE A 187
ASN A 159
 None
 0.96A 4d33A-1jovA:
undetectable		 4d33A-1jovA:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		6 SER A 477
ARG A 481
ASN A 498
ASN A 569
ASP A 709
TRP A 711
 None
 0.45A 4d33A-1lzxA:
58.7		 4d33A-1lzxA:
62.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN GAMMA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 ARG C 391
ASN C 189
ILE C 387
ASP C 152
 None
 1.05A 4d33A-1m1jC:
0.0		 4d33A-1m1jC:
20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		8 SER A 246
ARG A 250
ASN A 267
GLU A 269
ILE A 270
ASN A 338
ASP A 478
TRP A 480
 None
 0.60A 4d33A-1m9qA:
61.1		 4d33A-1m9qA:
95.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfa HUMAN TRANSCRIPTION
FACTOR NFATC1

(Homo sapiens) 		PF00554
(RHD_DNA_bind) 		4 SER A  23
ASN A 170
GLU A 173
ILE A 172
 None
 1.08A 4d33A-1nfaA:
0.0		 4d33A-1nfaA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh1 STAPHOSTATIN A

(Staphylococcus
aureus) 		PF09022
(Staphostatin_A) 		4 ASN A  25
ILE A  26
ASN A  85
TRP A  31
 None
 0.87A 4d33A-1oh1A:
0.0		 4d33A-1oh1A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE

(Rattus
norvegicus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 SER 1  64
ARG 1  14
ILE 1  17
TRP 1 148
 GSH  1 301 (-2.6A)
GSH  1 301 (-3.4A)
None
None
 0.93A 4d33A-1pd21:
undetectable		 4d33A-1pd21:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLU A 489
ILE A 490
ASN A 470
ASP A 472
 None
 1.13A 4d33A-1pvdA:
undetectable		 4d33A-1pvdA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdq CATHEPSIN B

(Bos taurus) 		PF00112
(Peptidase_C1) 		4 ASN A 156
GLU A 243
ILE A 160
TRP A 215
 None
 1.09A 4d33A-1qdqA:
undetectable		 4d33A-1qdqA:
19.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		5 SER A 256
ARG A 260
GLU A 279
ASN A 348
TRP A 490
 None
 0.56A 4d33A-1qw5A:
56.4		 4d33A-1qw5A:
57.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4a ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1

(Rattus
norvegicus) 		PF00025
(Arf) 		4 SER A 137
ILE A 155
ASN A 141
TRP A 153
 None
 1.06A 4d33A-1r4aA:
undetectable		 4d33A-1r4aA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sp4 CATHEPSIN B

(Bos taurus) 		PF00112
(Peptidase_C1) 		4 ASN B 156
GLU B 243
ILE B 160
TRP B 215
 None
 1.13A 4d33A-1sp4B:
undetectable		 4d33A-1sp4B:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		4 SER A 133
ASN A  75
GLU A  98
ASN A 134
 None
 1.02A 4d33A-1sqjA:
undetectable		 4d33A-1sqjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl2 ARGININOSUCCINATE
SYNTHASE

(Thermotoga
maritima) 		PF00764
(Arginosuc_synth) 		4 ASN A 259
GLU A 218
ILE A 351
ASN A 235
 None
 1.11A 4d33A-1vl2A:
undetectable		 4d33A-1vl2A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xup GLYCEROL KINASE

(Enterococcus
casseliflavus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 SER O 188
ARG O 189
ILE O 291
ASN O 194
 None
 1.06A 4d33A-1xupO:
undetectable		 4d33A-1xupO:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1za4 THROMBOSPONDIN 1

(Homo sapiens) 		PF02210
(Laminin_G_2) 		4 ARG A 180
ILE A  49
ASN A 189
ASP A  45
 None
 0.88A 4d33A-1za4A:
undetectable		 4d33A-1za4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 SER A 426
ASN A 148
GLU A 146
ASN A 423
 None
 1.13A 4d33A-2bihA:
undetectable		 4d33A-2bihA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bii NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 SER A 426
ARG A 144
GLU A 146
ASN A 423
 None
SO4  A 602 (-4.3A)
None
None
 1.06A 4d33A-2biiA:
undetectable		 4d33A-2biiA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7l PHYCOERYTHROCYANIN
ALPHA CHAIN
PHYCOERYTHROCYANIN
BETA CHAIN

(Mastigocladus
laminosus;
Mastigocladus
laminosus) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		4 ASN B  25
GLU B  23
ILE B  24
ASN A  46
 None
 0.93A 4d33A-2c7lB:
undetectable		 4d33A-2c7lB:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cit ENDOGLUCANASE H

(Ruminiclostridium
thermocellum) 		PF02156
(Glyco_hydro_26) 		4 SER A 166
ASN A 128
ILE A 119
ASN A 160
 None
 1.04A 4d33A-2citA:
undetectable		 4d33A-2citA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es3 THROMBOSPONDIN-1

(Homo sapiens) 		PF02210
(Laminin_G_2) 		4 ARG A 180
ILE A  49
ASN A 189
ASP A  45
 None
 1.00A 4d33A-2es3A:
undetectable		 4d33A-2es3A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		4 ASN A 408
ILE A 407
ASN A 398
ASP A 403
 None
 1.06A 4d33A-2f6dA:
undetectable		 4d33A-2f6dA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		4 ASN A 440
GLU A 385
ASN A 376
ASP A 339
 None
 1.10A 4d33A-2gj4A:
undetectable		 4d33A-2gj4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN

(Mus musculus) 		PF00617
(RasGEF) 		4 SER S1124
ARG S1127
GLU S1085
ILE S1086
 None
 1.00A 4d33A-2ijeS:
undetectable		 4d33A-2ijeS:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kcy 30S RIBOSOMAL
PROTEIN S8E

(Methanothermobacter
thermautotrophicus) 		PF01201
(Ribosomal_S8e) 		4 SER A  75
ARG A  76
ASN A  84
ASP A  80
 None
 1.04A 4d33A-2kcyA:
undetectable		 4d33A-2kcyA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P2

(Homo sapiens) 		PF00428
(Ribosomal_60s) 		5 SER B 117
ASN B 147
ILE B 143
ASN B 115
ASP B 122
 None
 1.48A 4d33A-2lbfB:
undetectable		 4d33A-2lbfB:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nd4 AMYLASE-BINDING
PROTEIN ABPA

(Streptococcus
parasanguinis) 		no annotation 4 ARG A 100
ASN A  39
ILE A 104
TRP A  31
 None
 0.95A 4d33A-2nd4A:
undetectable		 4d33A-2nd4A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obi PHOSPHOLIPID
HYDROPEROXIDE
GLUTATHIONE
PEROXIDASE (GPX4)

(Homo sapiens) 		PF00255
(GSHPx) 		4 ASN A  86
GLU A  88
ILE A  89
ASN A  76
 None
 1.02A 4d33A-2obiA:
undetectable		 4d33A-2obiA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p31 GLUTATHIONE
PEROXIDASE 7

(Homo sapiens) 		PF00255
(GSHPx) 		4 ASN A  97
GLU A  99
ILE A 100
ASN A  87
 None
 1.08A 4d33A-2p31A:
undetectable		 4d33A-2p31A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6w PUTATIVE
GLYCOSYLTRANSFERASE
(MANNOSYLTRANSFERASE
) INVOLVED IN
GLYCOSYLATING THE
PBCV-1 MAJOR CAPSID
PROTEIN

(Paramecium
bursaria
Chlorella virus
1) 		PF05637
(Glyco_transf_34) 		4 ARG A 166
ASN A 102
ILE A 103
TRP A  73
 None
 0.94A 4d33A-2p6wA:
undetectable		 4d33A-2p6wA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF00481
(PP2C) 		4 ARG A 187
ASN A 306
GLU A 308
ILE A 309
 None
 0.85A 4d33A-2popA:
undetectable		 4d33A-2popA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 SER A 419
GLU A 314
ILE A 313
ASN A 417
 None
 0.98A 4d33A-2q3zA:
undetectable		 4d33A-2q3zA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rld UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF05635
(23S_rRNA_IVP) 		4 ASN A 107
GLU A 105
ILE A 106
ASP A 102
 None
 1.11A 4d33A-2rldA:
undetectable		 4d33A-2rldA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bib T-CELL
IMMUNOGLOBULIN AND
MUCIN
DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		PF07686
(V-set) 		4 ASN X  28
ILE X  92
ASN X  99
ASP X 100
 None
None
NA  X 117 ( 3.2A)
PSF  X 118 ( 2.9A)
 1.14A 4d33A-3bibX:
undetectable		 4d33A-3bibX:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 ARG C 391
ASN C 189
ILE C 387
ASP C 152
 None
 1.08A 4d33A-3bvhC:
undetectable		 4d33A-3bvhC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 ASN A 440
GLU A 385
ASN A 376
ASP A 339
 None
 1.10A 4d33A-3cemA:
undetectable		 4d33A-3cemA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 ARG A 266
ASN A 283
GLU A 285
ASN A 354
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
None
 1.00A 4d33A-3e7gA:
54.1		 4d33A-3e7gA:
58.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas
putida) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 ASN A 419
ILE A 417
ASN A 409
ASP A 408
 None
 1.12A 4d33A-3eqqA:
undetectable		 4d33A-3eqqA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		4 SER A 146
ASN A 150
GLU A 148
ASN A 122
 None
 1.01A 4d33A-3fssA:
undetectable		 4d33A-3fssA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ge5 PUTATIVE NAD(P)H:FMN
OXIDOREDUCTASE

(Porphyromonas
gingivalis) 		PF00881
(Nitroreductase) 		4 ARG A  66
GLU A 136
ILE A 137
ASP A 139
 None
 0.96A 4d33A-3ge5A:
undetectable		 4d33A-3ge5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in1 UNCHARACTERIZED
SUGAR KINASE YDJH

(Escherichia
coli) 		PF00294
(PfkB) 		4 ASN A  98
ILE A  13
ASN A 144
ASP A  43
 None
 1.13A 4d33A-3in1A:
undetectable		 4d33A-3in1A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khj INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00478
(IMPDH) 		4 ASN A 184
ILE A 185
ASN A  38
ASP A 207
 None
 1.00A 4d33A-3khjA:
undetectable		 4d33A-3khjA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 ASN A 367
GLU A 370
ILE A 369
ASP A 371
 None
 0.96A 4d33A-3l44A:
undetectable		 4d33A-3l44A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9d PUTATIVE GTP
PYROPHOSPHOKINASE

(Streptococcus
mutans) 		PF04607
(RelA_SpoT) 		4 SER A  35
ARG A  25
ILE A  37
ASP A  83
 None
 1.13A 4d33A-3l9dA:
undetectable		 4d33A-3l9dA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9p PERIPLASMIC MUREIN
PEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 ARG A  41
GLU A  36
ILE A  40
ASN A 161
 None
 1.08A 4d33A-3o9pA:
undetectable		 4d33A-3o9pA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omb EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		4 SER A 521
ASN A 482
GLU A 484
ILE A 485
 None
 0.96A 4d33A-3ombA:
undetectable		 4d33A-3ombA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p09 BETA-LACTAMASE

(Francisella
tularensis) 		PF13354
(Beta-lactamase2) 		4 ASN A 162
GLU A 160
ILE A 161
ASN A 128
 None
 0.99A 4d33A-3p09A:
undetectable		 4d33A-3p09A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p14 L-RHAMNOSE ISOMERASE

(Bacillus
halodurans) 		PF06134
(RhaA) 		4 SER A 273
ASN A 270
GLU A 306
ASN A 314
 None
 0.99A 4d33A-3p14A:
undetectable		 4d33A-3p14A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps0 CRISPR-ASSOCIATED
PROTEIN, CSA2

(Sulfolobus
solfataricus) 		PF01905
(DevR) 		4 ARG A 147
GLU A 300
ILE A 299
ASP A 268
 None
 0.92A 4d33A-3ps0A:
undetectable		 4d33A-3ps0A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 SER A 543
ARG A 570
GLU A 546
ILE A 571
 None
 0.95A 4d33A-3qr1A:
undetectable		 4d33A-3qr1A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s3r CATHEPSIN B-LIKE
PEPTIDASE (C01
FAMILY)

(Schistosoma
mansoni) 		PF00112
(Peptidase_C1) 		4 SER A 315
GLU A 310
ILE A 313
ASN A 226
 None
 1.10A 4d33A-3s3rA:
undetectable		 4d33A-3s3rA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE

(Leptospirillum
rubarum) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 SER A 300
ARG A 262
GLU A 206
ILE A 302
 None
 0.91A 4d33A-3ttgA:
undetectable		 4d33A-3ttgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw5 TRANSGLUTAMINASE
ELICITOR

(Phytophthora
sojae) 		PF16683
(TGase_elicitor) 		4 ASN A 165
GLU A 477
ILE A 478
ASN A 373
 None
 1.05A 4d33A-3tw5A:
undetectable		 4d33A-3tw5A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 SER B2326
ASN B2318
ILE B2321
ASN B1472
 None
 0.79A 4d33A-3zefB:
undetectable		 4d33A-3zefB:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		4 SER A1740
ARG A1750
GLU A1850
ILE A1851
 None
 1.09A 4d33A-4asiA:
undetectable		 4d33A-4asiA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av2 TYPE IV PILUS
BIOGENESIS AND
COMPETENCE PROTEIN
PILQ

(Neisseria
meningitidis) 		PF03958
(Secretin_N)
PF07660
(STN) 		4 ARG A 402
ASN A 379
GLU A 356
ILE A 357
 None
 1.01A 4d33A-4av2A:
undetectable		 4d33A-4av2A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 ARG A 501
ASN A 510
ILE A 509
ASN A 497
 None
 1.07A 4d33A-4cj0A:
undetectable		 4d33A-4cj0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 ARG A  29
ASN A 272
ASN A 142
ASP A 145
 None
 1.12A 4d33A-4fn5A:
undetectable		 4d33A-4fn5A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i04 CATHEPSIN B-LIKE
PEPTIDASE (C01
FAMILY)

(Schistosoma
mansoni) 		PF00112
(Peptidase_C1)
PF08127
(Propeptide_C1) 		4 SER A 315
GLU A 310
ILE A 313
ASN A 226
 None
 1.10A 4d33A-4i04A:
undetectable		 4d33A-4i04A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i05 CATHEPSIN B-LIKE
PEPTIDASE (C01
FAMILY)

(Schistosoma
mansoni) 		PF00112
(Peptidase_C1) 		4 SER A 315
GLU A 310
ILE A 313
ASN A 226
 None
 0.95A 4d33A-4i05A:
undetectable		 4d33A-4i05A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i99 CHROMOSOME PARTITION
PROTEIN SMC
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF02463
(SMC_N)
no annotation 		4 SER A1144
GLU C 197
ILE C 198
ASN C 192
 None
 1.15A 4d33A-4i99A:
undetectable		 4d33A-4i99A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idi ORYZA SATIVA
RURM1-RELATED

(Plasmodium
yoelii) 		PF09138
(Urm1) 		4 SER A  55
ARG A  44
GLU A  37
ILE A  40
 None
 1.02A 4d33A-4idiA:
undetectable		 4d33A-4idiA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4x NP PROTEIN

(Sandfly fever
Naples
phlebovirus) 		PF05733
(Tenui_N) 		4 SER A 110
ASN A 101
GLU A  99
ASN A  66
 None
 0.96A 4d33A-4j4xA:
undetectable		 4d33A-4j4xA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 SER A 125
ARG A 130
GLU A  14
ASP A 224
 None
 1.10A 4d33A-4kcdA:
undetectable		 4d33A-4kcdA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9m RAS GUANYL-RELEASING
PROTEIN 1

(Homo sapiens) 		PF00130
(C1_1)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF13405
(EF-hand_6) 		4 SER A 456
ASN A 252
GLU A 245
ILE A 248
 None
 0.86A 4d33A-4l9mA:
undetectable		 4d33A-4l9mA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ASN A 324
GLU A 322
ILE A 323
ASN A 392
 None
 0.63A 4d33A-4na3A:
undetectable		 4d33A-4na3A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00496
(SBP_bac_5) 		4 GLU A  14
ILE A  15
ASN A 154
TRP A 168
 None
 1.02A 4d33A-4oetA:
undetectable		 4d33A-4oetA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ote LIPOPROTEIN

(Clostridioides
difficile) 		PF03180
(Lipoprotein_9) 		4 SER A 133
ILE A 183
ASN A 134
ASP A 179
 None
 1.13A 4d33A-4oteA:
undetectable		 4d33A-4oteA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5t LIPOPROTEIN

(Streptococcus
mutans) 		PF03180
(Lipoprotein_9) 		4 ASN A 235
GLU A 108
ILE A 236
ASN A  90
 None
 1.00A 4d33A-4q5tA:
undetectable		 4d33A-4q5tA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlz SJCHGC07024 PROTEIN

(Schistosoma
japonicum) 		PF00719
(Pyrophosphatase) 		4 ASN A  64
GLU A  56
ILE A  57
ASP A 115
 None
CO  A 403 (-3.4A)
None
CO  A 403 ( 3.5A)
 0.97A 4d33A-4qlzA:
undetectable		 4d33A-4qlzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvi AMINOTRANSFERASE,
CLASS IV

(Brucella
abortus) 		PF01063
(Aminotran_4) 		4 ARG A  36
ILE A  42
ASP A 136
TRP A 119
 None
 0.75A 4d33A-4tviA:
undetectable		 4d33A-4tviA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u66 PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Alkaliphilus
oremlandii) 		PF01625
(PMSR) 		4 ASN A 116
GLU A 113
ILE A 112
ASN A  80
 None
 1.07A 4d33A-4u66A:
undetectable		 4d33A-4u66A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uei STEROL CARRIER
PROTEIN
2/3-OXOACYL-COA
THIOLASE

(Helicoverpa
armigera) 		PF02036
(SCP2) 		4 ARG A  48
GLU A  37
ILE A  44
ASN A  69
 None
 0.83A 4d33A-4ueiA:
undetectable		 4d33A-4ueiA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8q UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF08713
(DNA_alkylation) 		4 SER A 163
ARG A 123
GLU A 158
ASN A 166
 None
 1.08A 4d33A-4x8qA:
undetectable		 4d33A-4x8qA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y25 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
EXPORT PROTEIN

(Escherichia
coli) 		no annotation 4 SER A 586
ASN A 588
ILE A 589
ASN A 554
 None
 0.98A 4d33A-4y25A:
undetectable		 4d33A-4y25A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Homo sapiens) 		PF01966
(HD) 		4 SER A 214
ARG A 164
GLU A 234
ASP A 218
 None
DG3  A2001 (-3.0A)
DG3  A2001 ( 4.3A)
None
 1.06A 4d33A-5ao0A:
undetectable		 4d33A-5ao0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuv ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
cruzi) 		PF00719
(Pyrophosphatase) 		4 ASN A 247
GLU A 239
ILE A 240
ASP A 293
 None
 0.84A 4d33A-5cuvA:
undetectable		 4d33A-5cuvA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2v GTP
PYROPHOSPHOKINASE
YJBM

(Bacillus
subtilis) 		no annotation 4 SER V  38
ARG V  28
ILE V  40
ASP V  85
 None
 1.11A 4d33A-5f2vV:
undetectable		 4d33A-5f2vV:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fre EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF02973
(Sialidase) 		4 GLU A  32
ILE A 111
ASN A 139
ASP A  31
 None
 1.14A 4d33A-5freA:
undetectable		 4d33A-5freA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5a GLUTATHIONE
S-TRANSFERASE U25

(Arabidopsis
thaliana) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 SER A  67
ARG A  18
GLU A  72
ILE A  71
 GSH  A1221 (-2.6A)
GSH  A1221 ( 4.9A)
None
None
 1.15A 4d33A-5g5aA:
undetectable		 4d33A-5g5aA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE

(Trypanosoma
cruzi) 		PF00262
(Calreticulin) 		4 ASN A 296
GLU A 205
ILE A 206
ASP A 208
 None
 1.10A 4d33A-5hcfA:
undetectable		 4d33A-5hcfA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		4 SER A 407
ARG A 409
ILE A 403
ASP A 262
 None
 1.04A 4d33A-5hzwA:
undetectable		 4d33A-5hzwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihe DNA POLYMERASE II
SMALL SUBUNIT

(Pyrococcus
abyssi) 		PF00149
(Metallophos) 		4 SER A 394
GLU A 389
ILE A 392
TRP A 379
 None
 0.98A 4d33A-5iheA:
undetectable		 4d33A-5iheA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 SER B1019
ARG B1020
ILE B1017
ASN A 757
 None
 1.15A 4d33A-5ip9B:
undetectable		 4d33A-5ip9B:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irc RHO
GTPASE-ACTIVATING
PROTEIN 35

(Rattus
norvegicus) 		PF00620
(RhoGAP) 		4 SER A1383
GLU A1426
ILE A1429
ASN A1386
 None
 1.09A 4d33A-5ircA:
undetectable		 4d33A-5ircA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw9 BASEPLATE WEDGE
PROTEIN GP25

(Escherichia
virus T4) 		PF04965
(GPW_gp25) 		4 SER A  79
ASN A  76
GLU A  74
ILE A  77
 None
 1.02A 4d33A-5iw9A:
undetectable		 4d33A-5iw9A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 SER A 170
GLU A 128
ILE A 127
ASP A 125
 None
 1.07A 4d33A-5j0aA:
undetectable		 4d33A-5j0aA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyg ACTIN-LIKE ATPASE

(Magnetospirillum
magneticum) 		PF06723
(MreB_Mbl) 		4 ARG A 305
GLU A 263
ILE A 262
ASP A 260
 None
 1.13A 4d33A-5jygA:
undetectable		 4d33A-5jygA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nf4 MINOR FIMBRIUM TIP
SUBUNIT MFA3

(Porphyromonas
gingivalis) 		no annotation 4 ASN A 222
GLU A 225
ILE A 252
ASN A 271
 None
 1.02A 4d33A-5nf4A:
undetectable		 4d33A-5nf4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzz TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 4 ARG A 187
ASN A 306
GLU A 308
ILE A 309
 None
 0.86A 4d33A-5nzzA:
undetectable		 4d33A-5nzzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B

(Methanothermobacter
sp. CaT2) 		PF00384
(Molybdopterin) 		4 ASN B  33
ILE B  19
ASN B   6
ASP B  17
 None
 1.03A 4d33A-5t5iB:
undetectable		 4d33A-5t5iB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		4 ASN A 125
ILE A 223
ASN A 185
ASP A 188
 None
 1.11A 4d33A-5xsyA:
undetectable		 4d33A-5xsyA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A

(Escherichia
coli;
Homo sapiens) 		no annotation 4 ASN A1006
GLU A1008
ASN A1013
ASP A1012
 None
 0.86A 4d33A-6aqfA:
undetectable		 4d33A-6aqfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 SER A2168
ARG A2169
GLU A2495
ILE A2165
 None
 1.14A 4d33A-6b3rA:
undetectable		 4d33A-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elw PHOSPHOLIPID
HYDROPEROXIDE
GLUTATHIONE
PEROXIDASE,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 ASN A  86
GLU A  88
ILE A  89
ASN A  76
 None
 1.03A 4d33A-6elwA:
undetectable		 4d33A-6elwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd 26S PROTEASOME
SUBUNIT S5A

(Rattus
norvegicus) 		no annotation 4 ASN W  12
GLU W 118
ILE W  84
ASP W 119
 None
 0.94A 4d33A-6epdW:
undetectable		 4d33A-6epdW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 4 SER D 309
ILE D 305
ASN D 312
ASP D 348
 None
 1.02A 4d33A-6fmlD:
undetectable		 4d33A-6fmlD:
undetectable