SIMILAR PATTERNS OF AMINO ACIDS FOR 4CSV_A_STIA1265_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 290
ILE A 332
MET A 337
PHE A 378
 P16  A   2 (-4.5A)
P16  A   2 (-4.1A)
None
None
 0.63A 4csvA-1opkA:
32.2		 4csvA-1opkA:
47.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A1980
ILE A2024
MET A2029
PHE A2075
 VGH  A3000 ( 4.7A)
None
None
None
 0.80A 4csvA-3zbfA:
25.9		 4csvA-3zbfA:
41.56