SIMILAR PATTERNS OF AMINO ACIDS FOR 4CSV_A_STIA1265

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  70
ALA A  83
GLU A  97
ILE A 100
MET A 101
VAL A 110
TYR A 134
LEU A 188
 None
 0.96A 4csvA-1gngA:
21.9		 4csvA-1gngA:
25.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
THR A 266
TYR A 268
LEU A 321
 None
 0.75A 4csvA-1k9aA:
31.3		 4csvA-1k9aA:
30.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 588
ALA A 606
MET A 629
VAL A 638
TYR A 656
LEU A 731
ALA A 741
ASP A 742
 None
 1.01A 4csvA-1lufA:
33.8		 4csvA-1lufA:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 275
ALA A 288
GLU A 305
MET A 309
THR A 334
LEU A 389
ALA A 399
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.65A 4csvA-1opkA:
32.5		 4csvA-1opkA:
47.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 275
ALA A 288
GLU A 305
MET A 309
VAL A 318
THR A 334
LEU A 389
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
 0.63A 4csvA-1opkA:
32.5		 4csvA-1opkA:
47.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 VAL A 219
ALA A 230
GLU A 245
ILE A 248
TYR A 282
LEU A 340
ALA A 350
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
PY1  A 700 (-4.6A)
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.79A 4csvA-1py5A:
20.2		 4csvA-1py5A:
31.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 603
ALA A 621
GLU A 640
THR A 670
TYR A 672
LEU A 799
ASP A 810
PHE A 811
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.84A 4csvA-1t46A:
32.4		 4csvA-1t46A:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
TYR A 672
LEU A 799
ASP A 810
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
 0.53A 4csvA-1t46A:
32.4		 4csvA-1t46A:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 352
ALA A 367
GLU A 386
ILE A 389
MET A 390
VAL A 399
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
None
STU  A 100 (-4.5A)
 0.58A 4csvA-1u59A:
31.1		 4csvA-1u59A:
41.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  23
ALA A  36
GLU A  55
ILE A  58
VAL A  68
TYR A  86
LEU A 137
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
 0.83A 4csvA-1zltA:
16.1		 4csvA-1zltA:
27.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL X  25
ALA X  37
GLU X  54
ILE X  57
MET X  58
VAL X  67
THR X  82
TYR X  84
LEU X 137
ALA X 147
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.68A 4csvA-2dq7X:
34.0		 4csvA-2dq7X:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
VAL A 323
THR A 338
TYR A 340
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.80A 4csvA-2h8hA:
32.0		 4csvA-2h8hA:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  67
ALA A  80
ILE A 103
MET A 104
VAL A 113
TYR A 131
ALA A 192
 None
 0.90A 4csvA-2hakA:
13.3		 4csvA-2hakA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  67
ILE A 103
MET A 104
VAL A 113
TYR A 131
LEU A 182
ALA A 192
 None
 1.11A 4csvA-2hakA:
13.3		 4csvA-2hakA:
28.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 643
ALA A 659
GLU A 678
ILE A 681
MET A 682
THR A 707
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.8A)
 0.78A 4csvA-2henA:
27.4		 4csvA-2henA:
43.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
THR A 316
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.02A 4csvA-2hk5A:
28.0		 4csvA-2hk5A:
58.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 269
GLU A 286
MET A 290
THR A 315
LEU A 370
ASP A 381
PHE A 382
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.7A)
GIN  A 600 (-4.9A)
GIN  A 600 (-4.0A)
 0.90A 4csvA-2hz0A:
33.2		 4csvA-2hz0A:
67.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
GLU A 286
MET A 290
VAL A 299
THR A 315
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.71A 4csvA-2hz0A:
33.2		 4csvA-2hz0A:
67.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 256
ALA A 269
GLU A 286
MET A 290
VAL A 299
THR A 315
LEU A 370
ALA A 380
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.62A 4csvA-2hz0A:
33.2		 4csvA-2hz0A:
67.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
THR A 316
TYR A 318
LEU A 371
ALA A 381
ASP A 382
PHE A 383
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.53A 4csvA-2og8A:
35.3		 4csvA-2og8A:
58.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 614
GLU A 633
MET A 637
VAL A 647
THR A 663
TYR A 665
ASP A 796
PHE A 797
 None
 1.00A 4csvA-2ogvA:
30.8		 4csvA-2ogvA:
38.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 596
ALA A 614
GLU A 633
ILE A 636
MET A 637
VAL A 647
THR A 663
TYR A 665
ASP A 796
 None
 0.76A 4csvA-2ogvA:
30.8		 4csvA-2ogvA:
38.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 596
ALA A 614
GLU A 633
ILE A 636
MET A 637
VAL A 647
THR A 663
TYR A 665
LEU A 785
 None
 0.74A 4csvA-2ogvA:
30.8		 4csvA-2ogvA:
38.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 838
ALA A 853
TYR A 904
LEU A 971
ALA A 981
ASP A 982
PHE A 983
 MR9  A 301 (-4.6A)
MR9  A 301 (-3.5A)
MR9  A 301 (-3.8A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
MR9  A 301 (-4.4A)
 0.45A 4csvA-2p4iA:
24.1		 4csvA-2p4iA:
38.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 495
ALA A 515
GLU A 534
MET A 538
TYR A 566
LEU A 633
ALA A 643
 None
 0.61A 4csvA-2psqA:
25.9		 4csvA-2psqA:
34.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 204
ALA A 215
GLU A 230
ILE A 233
THR A 265
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.4A)
None
 0.91A 4csvA-2qluA:
25.2		 4csvA-2qluA:
26.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 635
ALA A 651
GLU A 670
ILE A 673
MET A 674
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 0.94A 4csvA-2qobA:
27.5		 4csvA-2qobA:
39.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 689
ALA A 705
GLU A 724
ILE A 727
MET A 728
THR A 753
TYR A 755
ASP A 818
 None
 0.84A 4csvA-2r2pA:
32.8		 4csvA-2r2pA:
43.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 689
ALA A 705
ILE A 727
THR A 753
TYR A 755
LEU A 807
 None
 0.59A 4csvA-2r2pA:
32.8		 4csvA-2r2pA:
43.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 635
ALA A 651
ILE A 673
MET A 674
THR A 699
TYR A 701
LEU A 753
ASP A 764
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
None
Q9G  A1898 (-3.9A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-4.3A)
None
 0.76A 4csvA-2xyuA:
28.7		 4csvA-2xyuA:
45.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
GLU A 290
MET A 294
VAL A 303
THR A 319
ASP A 385
 None
 0.96A 4csvA-2zv7A:
27.2		 4csvA-2zv7A:
57.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
MET A 294
VAL A 303
THR A 319
ALA A 384
ASP A 385
 None
 0.95A 4csvA-2zv7A:
27.2		 4csvA-2zv7A:
57.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A1092
ALA A1108
GLU A1127
ILE A1130
MET A1131
TYR A1159
ALA A1221
ASP A1222
 CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
None
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
 0.99A 4csvA-3c1xA:
27.1		 4csvA-3c1xA:
33.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 492
ALA A 512
GLU A 531
MET A 535
TYR A 563
LEU A 630
ALA A 640
PHE A 489
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.72A 4csvA-3c4fA:
25.4		 4csvA-3c4fA:
41.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
THR A 266
TYR A 268
LEU A 321
 None
 0.75A 4csvA-3d7uA:
27.3		 4csvA-3d7uA:
46.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 647
ALA A 663
GLU A 682
ILE A 685
MET A 686
VAL A 695
ASP A 776
PHE A 777
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.6A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.77A 4csvA-3dkoA:
28.6		 4csvA-3dkoA:
41.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 647
ALA A 663
GLU A 682
ILE A 685
VAL A 695
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.6A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.81A 4csvA-3dkoA:
28.6		 4csvA-3dkoA:
41.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE

(Leishmania
major) 		PF00069
(Pkinase) 		7 VAL A  34
ALA A  47
GLU A  61
ILE A  64
MET A  65
VAL A  77
LEU A 158
 None
 0.86A 4csvA-3e3pA:
19.9		 4csvA-3e3pA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 VAL A  23
ALA A  36
GLU A  50
ILE A  53
MET A  54
TYR A 119
LEU A 173
 None
DRK  A 384 (-3.5A)
None
None
None
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
 0.72A 4csvA-3eb0A:
22.3		 4csvA-3eb0A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 VAL A  70
ALA A  83
ILE A 106
MET A 107
VAL A 116
TYR A 134
LEU A 185
ALA A 195
 None
 0.91A 4csvA-3fe3A:
22.6		 4csvA-3fe3A:
28.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 859
GLU A 878
ILE A 881
TYR A 911
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.9A)
None
None
8ST  A2001 ( 3.7A)
 0.85A 4csvA-3hngA:
32.0		 4csvA-3hngA:
35.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 841
ALA A 859
GLU A 878
ILE A 881
VAL A 892
TYR A 911
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
None
 0.72A 4csvA-3hngA:
32.0		 4csvA-3hngA:
35.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 GLU A 100
ILE A 103
MET A 104
VAL A 113
TYR A 131
LEU A 182
ALA A 192
 None
 0.97A 4csvA-3iecA:
23.1		 4csvA-3iecA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 GLU A 100
MET A 104
VAL A 113
TYR A 131
LEU A 182
ALA A 192
ASP A 193
 None
 1.14A 4csvA-3iecA:
23.1		 4csvA-3iecA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 VAL A  67
ALA A  80
ILE A 103
MET A 104
VAL A 113
TYR A 131
LEU A 182
ALA A 192
 None
 0.91A 4csvA-3iecA:
23.1		 4csvA-3iecA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 VAL A  67
ALA A  80
MET A 104
VAL A 113
TYR A 131
LEU A 182
ALA A 192
ASP A 193
 None
 0.83A 4csvA-3iecA:
23.1		 4csvA-3iecA:
27.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 649
ALA A 665
GLU A 684
ILE A 687
MET A 688
THR A 713
TYR A 715
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-4.1A)
None
 0.74A 4csvA-3kulA:
33.5		 4csvA-3kulA:
40.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		8 VAL A 218
ALA A 229
GLU A 244
ILE A 247
THR A 279
TYR A 281
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.78A 4csvA-3mdyA:
25.2		 4csvA-3mdyA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  33
ALA A  46
GLU A  66
ILE A  69
VAL A  79
LEU A 156
ALA A 166
 None
 0.84A 4csvA-3mi9A:
23.0		 4csvA-3mi9A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  57
ALA A  70
GLU A  91
ILE A  94
VAL A 104
TYR A 122
LEU A 173
 XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
XFE  A 351 (-4.6A)
 0.79A 4csvA-3mvjA:
21.7		 4csvA-3mvjA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 216
ALA A 227
GLU A 242
ILE A 245
THR A 277
TYR A 279
LEU A 337
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-4.6A)
None
 1.18A 4csvA-3my0A:
25.9		 4csvA-3my0A:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 216
ALA A 227
ILE A 245
THR A 277
TYR A 279
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 1.10A 4csvA-3my0A:
25.9		 4csvA-3my0A:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 ALA A  38
GLU A  58
ILE A  61
VAL A  72
TYR A  92
LEU A 141
ALA A 151
 None
 1.04A 4csvA-3oz6A:
21.1		 4csvA-3oz6A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 VAL A  25
ALA A  38
GLU A  58
VAL A  72
TYR A  92
LEU A 141
ALA A 151
 None
 0.89A 4csvA-3oz6A:
21.1		 4csvA-3oz6A:
24.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 ALA A 576
GLU A 596
ILE A 599
MET A 600
VAL A 609
THR A 625
TYR A 627
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
 0.62A 4csvA-3ppzA:
29.5		 4csvA-3ppzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 VAL A 565
ALA A 576
ILE A 599
MET A 600
VAL A 609
THR A 625
TYR A 627
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
 0.61A 4csvA-3ppzA:
29.5		 4csvA-3ppzA:
34.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  90
ALA A 103
GLU A 124
TYR A 155
LEU A 207
ALA A 217
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-4.0A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
 0.56A 4csvA-3qfvA:
19.3		 4csvA-3qfvA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 431
ALA A 443
MET A 464
VAL A 473
THR A 489
TYR A 491
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
 0.59A 4csvA-3sxsA:
32.3		 4csvA-3sxsA:
52.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
GLU A 531
MET A 535
TYR A 563
LEU A 630
ALA A 640
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.56A 4csvA-3tt0A:
31.0		 4csvA-3tt0A:
35.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 848
ALA A 866
GLU A 885
ILE A 888
LEU A1035
ASP A1046
PHE A1047
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.5A)
None
B49  A2000 (-4.0A)
 1.02A 4csvA-4agdA:
31.4		 4csvA-4agdA:
37.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 848
ALA A 866
GLU A 885
ILE A 888
VAL A 899
LEU A1035
ASP A1046
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.5A)
None
 0.89A 4csvA-4agdA:
31.4		 4csvA-4agdA:
37.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  50
ALA A  63
GLU A  81
ILE A  84
VAL A  94
LEU A 164
ALA A 174
 XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
None
XZN  A1317 (-4.4A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.74A 4csvA-4bc6A:
22.0		 4csvA-4bc6A:
27.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 VAL A 624
ALA A 653
GLU A 672
ILE A 675
MET A 676
THR A 701
TYR A 703
LEU A 773
ALA A 783
ASP A 784
PHE A 785
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.63A 4csvA-4ckrA:
31.4		 4csvA-4ckrA:
39.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 671
ALA A 684
GLU A 705
ILE A 708
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 1.04A 4csvA-4crsA:
17.1		 4csvA-4crsA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 671
ALA A 684
GLU A 705
VAL A 721
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.76A 4csvA-4crsA:
17.1		 4csvA-4crsA:
25.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		6 VAL A1040
ALA A1053
GLU A1078
ILE A1081
VAL A1091
ALA A1176
 None
 0.56A 4csvA-4f0gA:
22.2		 4csvA-4f0gA:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 836
ALA A 853
GLU A 871
ILE A 874
VAL A 884
TYR A 904
LEU A 956
ALA A 966
 19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
None
None
19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.71A 4csvA-4hviA:
29.9		 4csvA-4hviA:
37.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 486
ALA A 506
GLU A 525
MET A 529
TYR A 557
LEU A 624
ALA A 634
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 (-4.4A)
None
 0.78A 4csvA-4k33A:
26.2		 4csvA-4k33A:
38.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  41
ALA A  54
GLU A  70
ILE A  73
MET A  74
VAL A  83
TYR A 101
ALA A 163
 GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
None
None
GOL  A 403 (-4.1A)
GOL  A 404 ( 4.9A)
GOL  A 403 ( 3.0A)
 0.90A 4csvA-4lg4A:
18.5		 4csvA-4lg4A:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  41
ALA A  54
GLU A  70
MET A  74
VAL A  83
LEU A 153
ALA A 163
 GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
None
GOL  A 403 (-4.1A)
GOL  A 403 ( 4.4A)
GOL  A 403 ( 3.0A)
 1.16A 4csvA-4lg4A:
18.5		 4csvA-4lg4A:
26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
MET A 314
VAL A 323
TYR A 340
LEU A 393
ALA A 403
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.89A 4csvA-4lggA:
31.5		 4csvA-4lggA:
62.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL B  38
ALA B  51
GLU B  70
TYR B 101
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.85A 4csvA-4o27B:
19.6		 4csvA-4o27B:
30.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
LEU A 180
ASP A 191
 SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.5A)
None
 1.09A 4csvA-4o38A:
20.4		 4csvA-4o38A:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 635
ALA A 648
ILE A 672
VAL A 685
TYR A 703
LEU A 753
ALA A 763
 None
 1.00A 4csvA-4otdA:
22.7		 4csvA-4otdA:
26.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 627
ALA A 644
GLU A 663
MET A 667
THR A 692
TYR A 694
ASP A 757
 None
 1.12A 4csvA-4p2kA:
32.9		 4csvA-4p2kA:
43.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 624
ALA A 642
GLU A 661
VAL A 675
TYR A 693
LEU A 818
ASP A 829
PHE A 830
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.82A 4csvA-4rt7A:
26.3		 4csvA-4rt7A:
34.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
GLU A 661
MET A 665
VAL A 675
TYR A 693
LEU A 818
ASP A 829
 None
P30  A1001 (-3.6A)
P30  A1001 ( 3.7A)
None
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
None
 1.05A 4csvA-4rt7A:
26.3		 4csvA-4rt7A:
34.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		11 VAL A  22
ALA A  35
GLU A  52
ILE A  55
MET A  56
VAL A  65
THR A  81
TYR A  83
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.89A 4csvA-4ueuA:
35.8		 4csvA-4ueuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		7 VAL A 112
ALA A 125
GLU A 146
ILE A 149
VAL A 159
TYR A 177
LEU A 228
 ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
None
None
ATP  A 501 (-4.5A)
 0.93A 4csvA-4wb7A:
21.6		 4csvA-4wb7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  60
ALA A  72
GLU A  90
ILE A  93
MET A  94
VAL A 104
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-4.6A)
 0.85A 4csvA-4wsqA:
22.9		 4csvA-4wsqA:
25.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 481
ALA A 501
GLU A 520
MET A 524
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.56A 4csvA-4xcuA:
31.2		 4csvA-4xcuA:
42.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 VAL B 275
ALA B 288
MET B 309
THR B 334
LEU B 389
ALA B 399
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
1N1  B 601 (-3.3A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.56A 4csvA-4xeyB:
27.2		 4csvA-4xeyB:
48.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 624
ALA A 642
GLU A 661
VAL A 675
TYR A 693
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.78A 4csvA-4xufA:
26.4		 4csvA-4xufA:
41.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 624
ALA A 642
MET A 665
VAL A 675
TYR A 693
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 1.00A 4csvA-4xufA:
26.4		 4csvA-4xufA:
41.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 477
ALA A 488
GLU A 509
ILE A 512
THR A 539
TYR A 541
LEU A 595
ALA A 605
 None
4CV  A 801 (-3.5A)
None
None
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.60A 4csvA-4yffA:
20.4		 4csvA-4yffA:
33.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
GLU A 531
MET A 535
TYR A 563
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.60A 4csvA-5a46A:
31.4		 4csvA-5a46A:
36.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  30
ALA A  44
ILE A  66
VAL A  76
TYR A  94
LEU A 145
ALA A 164
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
None
51W  A 401 ( 3.4A)
51W  A 401 (-4.5A)
None
 0.87A 4csvA-5ci7A:
23.9		 4csvA-5ci7A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 ALA A  83
GLU A 103
ILE A 106
VAL A 116
TYR A 134
LEU A 185
ALA A 195
 5RC  A4000 (-3.6A)
None
None
None
5RC  A4000 (-4.5A)
None
5RC  A4000 ( 3.9A)
 1.05A 4csvA-5es1A:
23.7		 4csvA-5es1A:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  70
ALA A  83
GLU A 103
ILE A 106
TYR A 134
LEU A 185
ALA A 195
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
None
5RC  A4000 (-4.5A)
None
5RC  A4000 ( 3.9A)
 0.93A 4csvA-5es1A:
23.7		 4csvA-5es1A:
27.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 607
ALA A 625
GLU A 644
ILE A 647
MET A 648
VAL A 658
THR A 674
TYR A 676
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 ( 4.0A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.68A 4csvA-5grnA:
26.8		 4csvA-5grnA:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 607
ALA A 625
GLU A 644
THR A 674
TYR A 676
LEU A 825
ASP A 836
PHE A 837
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.82A 4csvA-5grnA:
26.8		 4csvA-5grnA:
37.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A  94
ALA A 105
VAL A 134
THR A 148
TYR A 150
LEU A 215
 None
 0.52A 4csvA-5gz8A:
19.0		 4csvA-5gz8A:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 VAL A  28
ALA A  41
GLU A  61
ILE A  64
VAL A  74
LEU A 143
ALA A 156
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.90A 4csvA-5hu3A:
23.9		 4csvA-5hu3A:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  65
ALA A  77
GLU A  95
ILE A  98
MET A  99
VAL A 109
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
None
None
IDV  A 401 (-4.4A)
 0.91A 4csvA-5i3oA:
22.4		 4csvA-5i3oA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  65
ALA A  77
ILE A  98
MET A  99
VAL A 109
TYR A 132
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.74A 4csvA-5i3oA:
22.4		 4csvA-5i3oA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  30
ALA A  43
GLU A  61
MET A  65
VAL A  74
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.84A 4csvA-5j5tA:
22.4		 4csvA-5j5tA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 284
ALA A 297
GLU A 315
MET A 319
VAL A 328
TYR A 346
LEU A 396
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
None
 0.99A 4csvA-5kbrA:
22.9		 4csvA-5kbrA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 8 VAL A 741
ALA A 754
GLU A 774
ILE A 777
VAL A 787
TYR A 815
LEU A 866
ALA A 876
 None
CJM  A1102 (-3.1A)
None
None
None
CJM  A1102 (-4.1A)
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
 0.68A 4csvA-6b3eA:
23.8		 4csvA-6b3eA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 9 VAL A  74
ALA A  87
GLU A 107
ILE A 110
MET A 111
VAL A 120
TYR A 138
LEU A 189
ALA A 199
 None
 1.04A 4csvA-6c9dA:
22.4		 4csvA-6c9dA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 VAL A 179
ALA A 192
GLU A 236
ILE A 239
VAL A 249
LEU A 319
ALA A 329
 F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 ( 4.7A)
None
None
F6J  A 501 (-4.5A)
F6J  A 501 ( 4.0A)
 0.87A 4csvA-6cmjA:
23.2		 4csvA-6cmjA:
14.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 290
ILE A 332
MET A 337
PHE A 378
 P16  A   2 (-4.5A)
P16  A   2 (-4.1A)
None
None
 0.63A 4csvA-1opkA:
32.2		 4csvA-1opkA:
47.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A1980
ILE A2024
MET A2029
PHE A2075
 VGH  A3000 ( 4.7A)
None
None
None
 0.80A 4csvA-3zbfA:
25.9		 4csvA-3zbfA:
41.56